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searching for S-Adenosyl methionine 28 found (353 total)

RSAD1 (79 words) [view diff] case mismatch in snippet view article find links to article

Radical S-adenosyl methionine domain containing 1 is a protein that in humans is encoded by the RSAD1 gene. GRCh38: Ensembl release 89: ENSG00000136444

Tazemetostat (731 words) [view diff] case mismatch in snippet view article find links to article

"tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyl transferase EZH2,

Coproporphyrinogen dehydrogenase (369 words) [view diff] case mismatch in snippet view article find links to article

oxygen-dependent oxidase within E. coli. Importantly, only HemN utilizes S-adenosyl Methionine (SAM). Human variants of Coproporphyrinogen oxidase are cofactor-independent

Xanthotoxol (94 words) [view diff] case mismatch in snippet view article find links to article

(8-hydroxyfuranocoumarin 8-O-methyltransferase) is an enzyme that uses S-adenosyl methionine and xanthotoxol to produce S-adenosylhomocysteine and O-methylxanthotoxol

Formylglycine-generating enzyme (1,211 words) [view diff] case mismatch in snippet view article find links to article

unique to the radical S-adenosyl methionine superfamily and are able to use a reduction reaction to cleave S-adenosyl methionine. These two enzymes fall

Imerslund–Gräsbeck syndrome (2,203 words) [view diff] case mismatch in snippet view article find links to article

converting it into methionine. Methionine is further converted to S-adenosyl methionine, which in turn gives of the extra carbon it received from THF, now

Spermine (704 words) [view diff] case mismatch in snippet view article find links to article

enzyme spermidine synthase effects two N-alkylation by decarboxy-S-adenosyl methionine. The intermediate is spermidine. Plants employ additional routes

Homocystinuria (1,361 words) [view diff] no match in snippet view article find links to article

The methionine that is not converted into protein is converted to S-adenosyl-methionine which goes on to form homocysteine again. Betaine is, therefore

Curacin A (794 words) [view diff] case mismatch in snippet view article find links to article

PKS modules follow to extend the growing polyketide chain with S-adenosyl methionine (SAM) dependent methylations occurring at positions 10 and 13. A

Urea-to-creatinine ratio (1,958 words) [view diff] case mismatch in snippet view article find links to article

The GAA is transported to the liver where it is methylated by S-adenosyl methionine (SAM) to form creatine. Creatine enters the circulation, and 90%

Enzyme Function Initiative (1,502 words) [view diff] exact match in snippet view article find links to article

unusual chemical transformations via an iron-sulfur cluster cleaving S-Adenosyl methionine (SAM) and producing a radical intermediate, or alternatively, abstraction

Neurotransmitter prodrug (2,931 words) [view diff] case mismatch in snippet view article find links to article

by the enzyme indolethylamine-N-methyltransferase (INMT) (using S-adenosyl methionine as a substrate), which catalyzes the addition of methyl groups resulting

Roland Douce (1,869 words) [view diff] case mismatch in snippet view article find links to article

are autonomous for de novo methionine synthesis and can import S-adenosyl methionine from the cytosol". J Biol Chem. 279 (21): 22548–22557. doi:10.1074/jbc

Cerebral folate deficiency (1,334 words) [view diff] no match in snippet view article find links to article

RFC: reduced folate carrier; SAH: S-adenosyl homocysteine; SAM: S-adenosyl-methionine; Ser: Serine; SHMT: serine-hydroxy methyl transferase; SM: sphingomyelin

Pyonitrin (722 words) [view diff] case mismatch in snippet view article find links to article

together with nicotinamide adenine dinucleotide phosphate (NADPH) and S-adenosyl methionine (SAM). For pyrrolnitrin half-pathway, the first step is the chlorination

Entebbe bat virus (1,152 words) [view diff] case mismatch in snippet view article find links to article

affinity is reduced by the presence of ATP or GTP and enhanced by S-adenosyl methionine (Henderson et al. 2011). Once translated, the polyprotein is cleaved

Amino acid synthesis (3,929 words) [view diff] no match in snippet view article find links to article

repressor protein MetJ, in cooperation with the corepressor protein S-adenosyl-methionine, mediates the repression of methionine's biosynthesis. The regulator

Hoiamides (881 words) [view diff] case mismatch in snippet view article find links to article

structural class of hoiamides is charactered by an acetate extended and S-adenosyl methionine modified isoleucine unit. Central to the molecule is a triheterocyclic

Mycoestrogen (1,243 words) [view diff] case mismatch in snippet view article find links to article

into mono-ethyl esters by catechol-o-methyl transferase (COMT) and S-adenosyl methionine (SAM). After this transformation they may be metabolized further

2,5-Diketopiperazine (2,289 words) [view diff] no match in snippet view article find links to article

linkage between two peptides. The enzymes cyclodipeptide oxidase and S-adenosyl-methionine-dependent O/N methyltransferases act in tandem to chemically modify

Deubiquitinating enzyme (4,309 words) [view diff] exact match in snippet view article find links to article

progression through the G1-S transition. SETD8, a methyltransferase, uses S-Adenosyl methionine to methylate the Lys20 residue of histone 4, resulting in the condensation

Fatty acid synthesis (4,751 words) [view diff] no match in snippet view article find links to article

fatty acid). After oleic acid is esterified to a phospholipid, S-adenosyl-methionine donates a methyl group to the double bond of oleic acid. This methylation

Management of schizophrenia (10,232 words) [view diff] no match in snippet view article find links to article

of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia". European Neuropsychopharmacology

EZH2 (5,393 words) [view diff] exact match in snippet view article find links to article

chains of substrate proteins. SET methyltransferases depend on a S-Adenosyl methionine (SAM) cofactor to act as a methyl donor for their catalytic activity

Systematic evolution of ligands by exponential enrichment (4,747 words) [view diff] case mismatch in snippet view article find links to article

DH, Gold L (May 1997). "RNA aptamers to the adenosine moiety of S-adenosyl methionine: structural inferences from variations on a theme and the reproducibility

Bottromycin (3,272 words) [view diff] case mismatch in snippet view article find links to article

O-methyltransferase, while the other three, btmC, G and K, are radical S-adenosyl methionine (SAM) methyltransferases. The radical SAM methyltransferases are

Biological effects of radiation on the epigenome (3,620 words) [view diff] case mismatch in snippet view article find links to article

Another mechanism that induces hypomethylation is the depletion of S-adenosyl methionine synthetase (SAM). The prevalence of super oxide species causes the

Epigenetics in learning and memory (6,235 words) [view diff] case mismatch in snippet view article find links to article

sites, while DNMT1 maintains established methylation patterns. S-adenosyl methionine acts as the methyl donor. One current hypothesis for how DNA methylation