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searching for EZH2 40 found (80 total)

alternate case: eZH2

PRC2 (542 words) [view diff] case mismatch in snippet view article find links to article

organisms. The mouse PRC2 has four subunits: Suz12 (zinc finger), Eed, Ezh1 or Ezh2 (SET domain with histone methyltransferase activity) and RbAp48 (histone
FAS-AS1 (357 words) [view diff] exact match in snippet view article find links to article
skipping. EZH2, often mutated or overexpressed in lymphomas, hyper-methylates the FAS-AS1 promoter and represses the FAS-AS1 expression. EZH2-mediated
SUZ12 (1,209 words) [view diff] exact match in snippet view article find links to article
histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Molecular Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020
Khalid Timani (313 words) [view diff] case mismatch in snippet view article find links to article
contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression. J Neurovirol. 2019 Aug;25(4):508-519. doi: 10.1007/s13365-019-00751-0
Mir-29 microRNA precursor (948 words) [view diff] exact match in snippet view article find links to article
J (Oct 2012). "Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas"
PPP1R8 (1,222 words) [view diff] exact match in snippet view article find links to article
shown to interact with PPP1CA, Histone deacetylase 2, SF3B1 EED and the EZH2 domain of PRC2. GRCh38: Ensembl release 89: ENSG00000117751 - Ensembl, May
NKX3-1 (2,348 words) [view diff] exact match in snippet view article find links to article
NKX3-1 was controlled by ERG and ESE3 both directly and through induction of EZH2 (Polycomb group pcg). Using a random cDNA sequencing approach, He et al.
Synthetic lethality (2,839 words) [view diff] exact match in snippet view article find links to article
expression occurs by either inhibition of the methyltransferase activity of EZH2, by inhibition of the DNA repair kinase ATR, or by exposure to the kinase
EHF (gene) (859 words) [view diff] exact match in snippet view article
C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate
Mesenchymal stem cell (4,548 words) [view diff] exact match in snippet view article find links to article
their multipotency. Recent work suggests that β-catenin, via regulation of EZH2, is a central molecule in maintaining the "stemness" of MSC's. The standard
Oncogenomics (7,610 words) [view diff] exact match in snippet view article find links to article
deficiency occurs by either inhibition of the methyltransferase activity of EZH2, or with addition of the kinase inhibitor dasatinib. Another approach is
Hovlinc (340 words) [view diff] exact match in snippet view article find links to article
retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2". Proceedings of the National Academy of Sciences. 117 (1): 415–425. doi:10
EPC1 (638 words) [view diff] exact match in snippet view article find links to article
complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10
Genentech (3,016 words) [view diff] exact match in snippet view article find links to article
partnered Epizyme to conduct clinical trials exploring whether Epizyme's EZH2 inhibitor tazemetostat would be synergistic with Genentech's atezolizumab
Multiple myeloma (10,134 words) [view diff] exact match in snippet view article find links to article
polycomb repressive complex 2 (PRC2).Increased expression of the PRC2 subunit, EZH2 have been described to be a common feature in multiple myeloma, resulting
Carla F. Kim (740 words) [view diff] exact match in snippet view article find links to article
Yi-Jang; Zhang, Haikuo; Marquez, Victor E.; Hammerman, Peter S. (2015-04-09). "EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors"
Cancer epigenetics (11,936 words) [view diff] exact match in snippet view article find links to article
chondrosarcoma, Ewing's sarcoma, and osteosarcoma, and expression of the EZH2 component of the PRC2 complex is altered in Ewing's sarcoma and rhabdomyosarcoma
Cytoskeleton regulator RNA (563 words) [view diff] exact match in snippet view article find links to article
non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer". Oncotarget. 7 (9): 9773–87
HOTAIR (1,226 words) [view diff] case mismatch in snippet view article find links to article
Neubert TA, Reinberg D (December 2010). "Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA". Genes & Development
Mir-205 (2,654 words) [view diff] exact match in snippet view article find links to article
to be involved in disease progression (i.e., interleukin 6, caveolin-1, EZH2). It also impaired cell growth, migration, clonability, and invasiveness
Enhancer of polycomb homolog 2 (drosophila) (516 words) [view diff] exact match in snippet view article
E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology
RNA immunoprecipitation chip (1,350 words) [view diff] case mismatch in snippet view article find links to article
immunoprecipitation procedure with RNA sequencing. Using specific antibodies (α-Ezh2) they immunoprecipitated nuclear RNA isolated from mouse ES cells, and subsequently
DAB2IP (861 words) [view diff] case mismatch in snippet view article find links to article
(2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer". J. Biol. Chem. 280 (23):
AEBP2 (321 words) [view diff] exact match in snippet view article find links to article
histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Mol. Cell. 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548
YWHAZ (3,610 words) [view diff] exact match in snippet view article find links to article
C, Ding J, Liao G, Tang B (2014). "Aberrant upregulation of 14-3-3σ and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular
Structural Genomics Consortium (5,323 words) [view diff] exact match in snippet view article find links to article
include PFI-1 and JQ1 for the BET family, UNC0642 for G9a/GLP, UNC1999 for EZH2/H1, LLY-283 and GSK591 for PRMT5, and OICR-9429 for WDR5. The WDR5 chemical
Alpha-methylacyl-CoA racemase (2,201 words) [view diff] exact match in snippet view article find links to article
Otte AP, Rubin MA, Chinnaiyan AM (Oct 2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer" (PDF). Nature. 419 (6907):
Baek Sung-hee (1,079 words) [view diff] exact match in snippet view article find links to article
Noh, Dong-Young; Kim, Keun Il; Kim, Kyeong Kyu; Baek, Sung Hee (2012). "EZH2 Generates a Methyl Degron that is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin
Weiping Zou (1,117 words) [view diff] exact match in snippet view article find links to article
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nature immunology 17, 95-103 (2016). Wang, W
Jeannie T. Lee (1,428 words) [view diff] exact match in snippet view article find links to article
Alfredo J.; Lee, Jeannie T. (2016-12-15). "Destabilization of B2 RNA by EZH2 Activates the Stress Response". Cell. 167 (7): 1788–1802.e13. doi:10.1016/j
RNF144A (909 words) [view diff] exact match in snippet view article find links to article
(November 2017). "Targeting glioma stem cells through combined BMI1 and EZH2 inhibition". Nature Medicine. 23 (11): 1352–1361. doi:10.1038/nm.4415. PMC 5679732
Extranodal NK/T-cell lymphoma, nasal type (5,378 words) [view diff] exact match in snippet view article find links to article
thereby rendering them resistant to this class of chemotherapy drugs; 4) EZH2, a histone methyltransferase that when up-regulated indirectly promotes these
Ataxia–telangiectasia (10,462 words) [view diff] exact match in snippet view article find links to article
Hart RP, Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K (December 2013). "EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia–telangiectasia"
Intravascular lymphomas (4,731 words) [view diff] exact match in snippet view article find links to article
Hacioglu S, Sari I, Bagci G, Keskin A (March 2016). "Mutational status of EZH2 and CD79B hot spots in mature B-cell non-Hodgkin's lymphomas: novel CD79B
Douglas Scherr (2,367 words) [view diff] exact match in snippet view article find links to article
DS; Gudas, LJ (2005). "Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder". Clinical Cancer Research
Mir-25 microRNA precursor family (2,415 words) [view diff] exact match in snippet view article find links to article
development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2". The Journal of Clinical Endocrinology and Metabolism. 97 (5): E710-8. doi:10
Robert E. Kingston (2,115 words) [view diff] case mismatch in snippet view article find links to article
the formation of diseases, Kingston's discovery of direct interactions (Ezh2 subunit) and PRC2 cofactors (Gtl2 RNA) really contributed to identifying
Farah Lubin (2,426 words) [view diff] exact match in snippet view article find links to article
1038/s41598-018-37761-7 Jarome TJ, Perez GA, Hauser RM, Hatch KM, Lubin FD. 2018. EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During
Pharmacoepigenetics (4,114 words) [view diff] exact match in snippet view article find links to article
lead to another type of cancer. Trying to modify these proteins, such as EZH2, may give rise to other types of cancer. Selectivity is another hurdle in
Genome-wide CRISPR-Cas9 knockout screens (6,102 words) [view diff] exact match in snippet view article find links to article
"CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2". The Journal of Clinical Investigation. 128 (1): 446–462. doi:10.1172/JCI90793