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searching for MTORC1 67 found (127 total)

alternate case: mTORC1

Cell proliferation (646 words) [view diff] exact match in snippet view article find links to article

metabolism, which is responsible for cell proliferation, can be regulated by mTORC1 signaling. In addition, intake of nutrients in animals can induce circulating

Leucine (4,132 words) [view diff] exact match in snippet view article find links to article

up-regulation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), a signaling cascade involved in coordination of translation initiation

Michael N. Hall (1,766 words) [view diff] exact match in snippet view article find links to article

and regulates a different signaling pathway from mTORC1. Hall also identified many roles of mTORC1 and mTORC2, including ribosomes physically interact

Sterol regulatory element-binding protein (2,125 words) [view diff] exact match in snippet view article find links to article

branched-chain amino acids stimulates expression of the SREBP-1c gene via the mTORC1/S6K1 pathway. The phosphorylation of S6K1 was increased in the liver of

Bicarbonate (1,159 words) [view diff] exact match in snippet view article find links to article

also demonstrated that cellular bicarbonate metabolism can be regulated by mTORC1 signaling. Additionally, bicarbonate plays a key role in the digestive system

LARP1 (1,320 words) [view diff] exact match in snippet view article find links to article

LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates

SESN2 (774 words) [view diff] exact match in snippet view article find links to article

has been found to activate the mammalian target of rapamycin complex 1 (mTORC1) pathway in the medial prefrontal cortex (mPFC) of the brain as an essential

Solute carrier family 38 member 9 (317 words) [view diff] exact match in snippet view article find links to article

a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477–81. Bibcode:2015Natur.519..477R. doi:10.1038/nature14107

Amino acid activation (1,608 words) [view diff] exact match in snippet view article find links to article

treatment of interleukin-18 activated cells triggers the mTORC1 metabolic sensor, which indicates that mTORC1 causes amino acid-driven activation due to a high

Tuberous sclerosis protein (1,075 words) [view diff] exact match in snippet view article find links to article

signaling pathways controlling mTOR signaling, by regulating especially mTORC1 activity. TSC2 contains a GTPase Activating Protein (GAP) domain which has

NKG2D (3,695 words) [view diff] exact match in snippet view article find links to article

(mTORC1) – memory precursor cells are characteristic by the low level of mTORC1 and for terminally differentiated CD8+ T cells, high level of mTORC1 activity

AKT1S1 (747 words) [view diff] exact match in snippet view article find links to article

Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007

Late endosomal/lysosomal adaptor, mapk and mtor activator 1 (542 words) [view diff] exact match in snippet view article find links to article

Markhard AL, Nada S, Sabatini DM (April 2010). "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids"

Nucleotide (3,305 words) [view diff] exact match in snippet view article find links to article

also demonstrated that cellular bicarbonate metabolism can be regulated by mTORC1 signaling. The liver is the major organ of de novo synthesis of all four

Β-Hydroxy β-methylbutyric acid (9,982 words) [view diff] exact match in snippet view article find links to article

including the activation of mechanistic target of rapamycin complex 1 (mTORC1) and inhibition of proteasome-mediated proteolysis in skeletal muscles.

Gabriella Gobbi (1,380 words) [view diff] exact match in snippet view article find links to article

(2021). Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceedings of the National Academy

Autophagy-related protein 13 (840 words) [view diff] exact match in snippet view article find links to article

Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy".

Imidazol-4-one-5-propionic acid (200 words) [view diff] exact match in snippet view article find links to article

"Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1". Cell. 175 (4): 947–961.e17. doi:10.1016/j.cell.2018.09.055. PMID 30401435

Lymphangioleiomyomatosis (11,094 words) [view diff] exact match in snippet view article find links to article

multiprotein complexes: the rapamycin-sensitive mTORC1 and the rapamycin-insensitive mTORC2. MTORC1 consists of five proteins including Raptor that positively

Branched-chain amino acid aminotransferase (3,560 words) [view diff] exact match in snippet view article find links to article

in insulin secretion from other metabolic pathways. BCATc regulates the mTORC1 signaling and TCR-induced glycolytic metabolism pathways during CD4+ T cell

NFE2L1 (3,660 words) [view diff] exact match in snippet view article find links to article

pone.0029167. PMC 3244438. PMID 22216197. Zhang Y, Manning BD (2015). "mTORC1 signaling activates NRF1 to increase cellular proteasome levels". Cell Cycle

Akt/PKB signaling pathway (4,072 words) [view diff] exact match in snippet view article find links to article

(IRS-1) transcription is down-regulated, in a negative feedback loop via mTORC1 and S6K1 activation. S6K1 is also able to phosphorylate IRS-1 at multiple

Maria Cardenas-Corona (280 words) [view diff] exact match in snippet view article find links to article

rapamycin, the dissection of its target in the mTORC1 signaling cascade, and the characterization of mTORC1 roles in cell fitness and growth control. Simultaneously

Geroprotector (456 words) [view diff] exact match in snippet view article find links to article

Dudley W (2020-01-01). "Next Generation Strategies for Geroprotection via mTORC1 Inhibition". The Journals of Gerontology: Series A. 75 (1): 14–23. doi:10

ABTL0812 (270 words) [view diff] exact match in snippet view article find links to article

JA, et al. (May 2016). "The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase". Clinical Cancer Research

AMP-activated protein kinase (7,149 words) [view diff] exact match in snippet view article find links to article

1A.66, and eEF2K. When TSC2 is activated it inhibits mTORC1. As a result of inhibition of mTORC1 by AMPK, protein synthesis comes to a halt. Activation

Phosphatidic acid (3,086 words) [view diff] exact match in snippet view article find links to article

PMID 9324933. Wiczer, Brian M; Thomas, George (27 Mar 2012). "Phospholipase D and mTORC1: Nutrients Are What Bring Them Together". Sci. Signal. 5 (217): pe13. doi:10

SESN3 (422 words) [view diff] exact match in snippet view article find links to article

Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev

Oncogene (3,173 words) [view diff] exact match in snippet view article find links to article

the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2". International Journal of Molecular Sciences. 23 (15): 8798

Protein kinase B (3,831 words) [view diff] exact match in snippet view article find links to article

Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, et al. (February 2017). "mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance

MAP4K3 (643 words) [view diff] exact match in snippet view article find links to article

Roscher AA, Ensenauer R (2013). "Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism". J. Nutr. Biochem. 24 (5):

Angus W. Thomson (379 words) [view diff] exact match in snippet view article find links to article

Angus W. (December 2017). "Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection"

Branched-chain amino acid (3,420 words) [view diff] exact match in snippet view article find links to article

PMID 22442749. Balcazar Morales N, Aguilar de Plata C (July 2012). "Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation". Colombia Medica. 43 (3): 235–43

Kim Sung-hoon (biologist) (638 words) [view diff] exact match in snippet view article

Cell - Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway "KOFST 한국과학기술단체총연합회". Archived from the original on 2013-06-16

Acute myeloblastic leukemia with maturation (3,160 words) [view diff] exact match in snippet view article find links to article

DEK-NUP214, it was found that the fusion oncoprotein caused an upregulation of mTORC1 (Sanden et al., 2013). Thus, a mTORC inhibitor could be a potential treatment

Carol MacKintosh (719 words) [view diff] exact match in snippet view article find links to article

DOI:10.1073/pnas.1600581113 The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids eLife 22 April 2016 DOI: 10

Jin Zhang (biochemist) (1,122 words) [view diff] exact match in snippet view article

; Wong, G. William; Zhang, Jin (2015-03-17). "Dynamic Visualization of mTORC1 Activity in Living Cells". Cell Reports. 10 (10): 1767–1777. doi:10.1016/j

DDIT4 (1,505 words) [view diff] exact match in snippet view article find links to article

with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1". The Journal of Nutrition. 139 (5): 828–834. doi:10.3945/jn

INSIG2 (1,582 words) [view diff] exact match in snippet view article find links to article

2011). "Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways". Cell Metab. 14 (1): 21–32. doi:10.1016/j

Signal transduction (7,609 words) [view diff] exact match in snippet view article find links to article

hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. EMBO Journal 35:1902-22 Smogorzewska A, de Lange T (August

Bing Liu (scientist) (783 words) [view diff] exact match in snippet view article

Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1", Frontiers in Pharmacology, 10:191 (2019). doi: 10.3389/fphar.2019.00191

Grimace scale (4,376 words) [view diff] exact match in snippet view article find links to article

Sorge, R.E., Yan, J., Asiedu, M.N., Valdez, A., ... & Price, T.J. (2013). "mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK"

Eric Winer (985 words) [view diff] exact match in snippet view article find links to article

Ni J, Ramkissoon SH, Xie S, et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts

DEPDC5 (1,368 words) [view diff] exact match in snippet view article find links to article

GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1". Science. 340 (6136): 1100–6. Bibcode:2013Sci...340.1100B. doi:10.1126/science

Volker Haucke (1,384 words) [view diff] exact match in snippet view article find links to article

Danilo; Falasca, Marco; Schultz, Carsten; Haucke, Volker (2017-06-02), "mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

Immunosenescence (3,559 words) [view diff] exact match in snippet view article find links to article

Macaulay R, Griffiths SJ, et al. (September 2014). "p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells". The Journal of Clinical

Basic helix-loop-helix ARNT-like protein 1 (5,804 words) [view diff] exact match in snippet view article find links to article

behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition". Mol Psychiatry. 28 (9): 3727–3738. doi:10.1038/s41380-022-01499-6

Autophagy (9,300 words) [view diff] exact match in snippet view article find links to article

Kim YM, Jung CH, Seo M, Kim EK, Park JM, Bae SS, Kim DH (January 2015). "mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation"

Fibroblast growth factor 21 (3,038 words) [view diff] exact match in snippet view article find links to article

methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms". FASEB Journal. 32 (6): 3471–3482. doi:10.1096/fj

Birt–Hogg–Dubé syndrome (4,557 words) [view diff] exact match in snippet view article find links to article

Fiore PP, Huber LA, Ballabio A (September 2020). "A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome". Nature. 585 (7826): 597–602

George Sai Wah Tsao (457 words) [view diff] exact match in snippet view article find links to article

Membrane Protein-1 upregulates glucose transporter-1 transcription via the mTORC1/NF-κB signaling pathways. J Virol. 2017. In press. Tsang CM, Yip YL, Lo

Childhood obesity (10,157 words) [view diff] exact match in snippet view article find links to article

1093/epirev/mxm004. PMID 17566051. Melnik, Bodo C. (2012-01-01). "Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand

Ataxia–telangiectasia (10,515 words) [view diff] exact match in snippet view article find links to article

Walker CL (March 2010). "ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS". Proceedings of the National Academy of Sciences of

NEDD4 (3,414 words) [view diff] exact match in snippet view article find links to article

"Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth". Proc. Natl. Acad. Sci. U.S.A. 111

Thomas A. Rando (1,536 words) [view diff] exact match in snippet view article find links to article

Namrata; Liu, Ling; Tsai, Chang-Ru; Goodell, Margaret A. (2014-06-19). "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert"

Tumor metabolome (2,581 words) [view diff] exact match in snippet view article find links to article

Glutaminolysis is linked to cisplatin resistance via the activation of mTORC1 signaling in gastric cancer. NADPH plays an important role as an antioxidant

Infant formula (11,818 words) [view diff] exact match in snippet view article find links to article

Mayo Clinic Specialist" Melnik BC (January 1, 2012). "Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand

Bruce Beutler (12,093 words) [view diff] exact match in snippet view article find links to article

leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling". Proceedings of the National Academy of Sciences of the United

Owen Sansom (1,888 words) [view diff] exact match in snippet view article find links to article

Sonenberg, N; Meyuhas, O; Hall, MN; Bushell, M; Willis, AE; Sansom, OJ (2015). "mTORC1-mediated translational elongation limits intestinal tumour initiation and

Long non-coding RNA (13,137 words) [view diff] exact match in snippet view article find links to article

Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP (January 2017). "mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide"

Jonathan C. Kagan (3,468 words) [view diff] exact match in snippet view article find links to article

also identified reactive oxygen species, controlled by the Ragulator-Rag-mTORC1 pathway, as regulators of GSDMD, with oxidation of a specific cysteine within

NEDD4L (3,265 words) [view diff] exact match in snippet view article find links to article

"Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth". Proc. Natl. Acad. Sci. U.S.A. 111

Stress granule (12,460 words) [view diff] exact match in snippet view article find links to article

MT, Boehlke C, Kläsener K, Ruf S, et al. (August 2013). "Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells". Cell

AMBRA1 (1,490 words) [view diff] exact match in snippet view article find links to article

them down, autophagy is initiated. AMBRA1 regulates the activity of the mTORC1 complex and this complex serves as a regulator of cell metabolism and growth

List of investigational antidepressants (11,183 words) [view diff] exact match in snippet view article find links to article

SPN-821) – sestrin2 modulator and mammalian target of rapamycin complex 1 (mTORC1) stimulant Tebideutorexant (JNJ-61393215; JNJ-3215) – orexin OX1 receptor

Giulio Superti-Furga (4,526 words) [view diff] exact match in snippet view article find links to article

a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477–481. Bibcode:2015Natur.519..477R. doi:10.1038/nature14107

Pparg coactivator 1 alpha (3,863 words) [view diff] exact match in snippet view article find links to article

(December 2011). "Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function". Proc