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searching for MTORC1 64 found (117 total)

alternate case: mTORC1

Leucine (3,799 words) [view diff] exact match in snippet view article find links to article

up-regulation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), a signaling cascade involved in coordination of translation initiation
Amino acid activation (575 words) [view diff] exact match in snippet view article find links to article
leucin NK treatment of IL-18 activated cells triggers mTORC1 metabolic sensor, which indicates that mTORC1 causes amino acid-driven activation due to a high
Solute carrier family 38 member 9 (317 words) [view diff] exact match in snippet view article find links to article
a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477–81. Bibcode:2015Natur.519..477R. doi:10.1038/nature14107
Sterol regulatory element-binding protein (2,061 words) [view diff] exact match in snippet view article find links to article
branched-chain amino acids stimulates expression of the SREBP-1c gene via the mTORC1/S6K1 pathway. The phosphorylation of S6K1 was increased in the liver of
Tuberous sclerosis protein (1,070 words) [view diff] exact match in snippet view article find links to article
signaling pathways controlling mTOR signaling, by regulating especially mTORC1 activity. TSC2 contains a GTPase Activating Protein (GAP) domain which has
LARP1 (1,363 words) [view diff] exact match in snippet view article find links to article
LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates
SESN2 (727 words) [view diff] exact match in snippet view article find links to article
has been found to activate the mammalian target of rapamycin complex 1 (mTORC1) pathway in the medial prefrontal cortex (mPFC) of the brain as an essential
NKG2D (3,677 words) [view diff] exact match in snippet view article find links to article
(mTORC1) – memory precursor cells are characteristic by the low level of mTORC1 and for terminally differentiated CD8+ T cells, high level of mTORC1 activity
Ketogenic amino acid (500 words) [view diff] exact match in snippet view article find links to article
metabolic pathway for insulin via activation of the rapamycin complex 1 (mTORC1) and protein S6 kinase 1 (S6K1) for which over-activation leads to insulin
AKT1S1 (743 words) [view diff] exact match in snippet view article find links to article
Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell. 25 (6): 903–15. doi:10.1016/j.molcel.2007
Maria Cardenas-Corona (280 words) [view diff] exact match in snippet view article find links to article
rapamycin, the dissection of its target in the mTORC1 signaling cascade, and the characterization of mTORC1 roles in cell fitness and growth control. Simultaneously
Beta-Hydroxy beta-methylbutyric acid (9,736 words) [view diff] exact match in snippet view article find links to article
including the activation of mechanistic target of rapamycin complex 1 (mTORC1) and inhibition of proteasome-mediated proteolysis in skeletal muscles.
List of investigational antidepressants (2,253 words) [view diff] exact match in snippet view article find links to article
sestrin2 modulator and consequent mammalian target of rapamycin complex 1 (mTORC1) activator SNG-12 – undefined mechanism of action [20] TS-121 – vasopressin
Squamous cell skin cancer (4,930 words) [view diff] exact match in snippet view article find links to article
Mutation in the Tpl2 gene causes the overexpression of FGFR2, which activates mTORC1 and AKT pathways in both primary and metastatic cSCC cell lines. Only by
Late endosomal/lysosomal adaptor, mapk and mtor activator 1 (538 words) [view diff] exact match in snippet view article find links to article
Markhard AL, Nada S, Sabatini DM (April 2010). "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids"
Protein kinase B (3,715 words) [view diff] exact match in snippet view article find links to article
P.P. et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317–1322 (2011)
Lymphangioleiomyomatosis (11,056 words) [view diff] exact match in snippet view article find links to article
multiprotein complexes: the rapamycin-sensitive mTORC1 and the rapamycin-insensitive mTORC2. MTORC1 consists of five proteins including Raptor that positively
NFE2L1 (3,647 words) [view diff] exact match in snippet view article find links to article
pone.0029167. PMC 3244438. PMID 22216197. Zhang Y, Manning BD (2015). "mTORC1 signaling activates NRF1 to increase cellular proteasome levels". Cell Cycle
Branched-chain amino acid aminotransferase (3,543 words) [view diff] exact match in snippet view article find links to article
in insulin secretion from other metabolic pathways. BCATc regulates the mTORC1 signaling and TCR-induced glycolytic metabolism pathways during CD4+ T cell
Autophagy-related protein 13 (833 words) [view diff] exact match in snippet view article find links to article
Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy".
SESN3 (422 words) [view diff] exact match in snippet view article find links to article
Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev
PDIA3 (1,182 words) [view diff] exact match in snippet view article find links to article
cysteines. This function allows it to serve as a redox sensor by activating mTORC1, which then mediates mTOR complex assembly to adapt cells to oxidative damage
Akt/PKB signaling pathway (4,090 words) [view diff] exact match in snippet view article find links to article
(IRS-1) transcription is down-regulated, in a negative feedback loop via mTORC1 and S6K1 activation. S6K1 is also able to phosphorylate IRS-1 at multiple
Insulin-like growth factor 1 (3,410 words) [view diff] exact match in snippet view article find links to article
to inhibit the mTORC1 complex. mTORC2 remains unaffected and responds by up-regulating AKT, driving signals through the inhibited mTORC1. Phosphorylation
AMP-activated protein kinase (6,460 words) [view diff] exact match in snippet view article find links to article
1A.66, and eEF2K. When TSC2 is activated it inhibits mTORC1. As a result of inhibition of mTORC1 by AMPK, protein synthesis comes to a halt. Activation
MAP4K3 (643 words) [view diff] exact match in snippet view article find links to article
Roscher AA, Ensenauer R (2013). "Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism". J. Nutr. Biochem. 24 (5):
Phosphatidic acid (3,069 words) [view diff] exact match in snippet view article find links to article
PMID 9324933. Wiczer, Brian M; Thomas, George (27 Mar 2012). "Phospholipase D and mTORC1: Nutrients Are What Bring Them Together". Sci. Signal. 5 (217): pe13. doi:10
ABTL0812 (267 words) [view diff] exact match in snippet view article find links to article
JA, et al. (May 2016). "The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase". Clinical Cancer Research
Angus W. Thomson (373 words) [view diff] exact match in snippet view article find links to article
Angus W. (December 2017). "Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection"
Branched-chain amino acid (3,247 words) [view diff] exact match in snippet view article find links to article
PMID 22442749. Balcazar Morales N, Aguilar de Plata C (July 2012). "Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation". Colombia Medica. 43 (3): 235–43
Phosphoinositide 3-kinase inhibitor (2,693 words) [view diff] exact match in snippet view article find links to article
Fuereder T, Zebedin E, Wacheck V (February 2011). "Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro
Kim Sung-hoon (biologist) (628 words) [view diff] exact match in snippet view article
Cell - Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway "KOFST 한국과학기술단체총연합회". Archived from the original on 2013-06-16
Methionine (3,992 words) [view diff] exact match in snippet view article find links to article
methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms". FASEB Journal. 32 (6): 3471–3482. doi:10.1096/fj
Life Sciences Institute (1,145 words) [view diff] exact match in snippet view article find links to article
World Conference. Retrieved 2019-01-30. Inoki, Ken. "Molecular mechanism of mTORC1-dependent translation and ribosome biogenesis". Cite journal requires |journal=
Acute myeloblastic leukemia with maturation (3,154 words) [view diff] exact match in snippet view article find links to article
DEK-NUP214, it was found that the fusion oncoprotein caused an upregulation of mTORC1 (Sanden et al., 2013). Thus, a mTORC inhibitor could be a potential treatment
PPARGC1A (2,970 words) [view diff] exact match in snippet view article find links to article
(December 2011). "Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function". Proc
INSIG2 (1,570 words) [view diff] exact match in snippet view article find links to article
2011). "Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways". Cell Metab. 14 (1): 21–32. doi:10.1016/j
HU-308 (3,880 words) [view diff] exact match in snippet view article find links to article
Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling". Journal of Biological Chemistry. 287 (2): 1198–1209. doi:10
Signal transduction (7,544 words) [view diff] exact match in snippet view article find links to article
hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. EMBO Journal 35:1902-22 Smogorzewska A, de Lange T (August
DDIT4 (1,504 words) [view diff] exact match in snippet view article find links to article
with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1". The Journal of Nutrition. 139 (5): 828–834. doi:10.3945/jn
Eric Winer (931 words) [view diff] exact match in snippet view article find links to article
Ni J, Ramkissoon SH, Xie S, et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts
Jin Zhang (biochemist) (1,097 words) [view diff] exact match in snippet view article
; Wong, G. William; Zhang, Jin (2015-03-17). "Dynamic Visualization of mTORC1 Activity in Living Cells". Cell Reports. 10 (10): 1767–1777. doi:10.1016/j
Carol MacKintosh (719 words) [view diff] exact match in snippet view article find links to article
DOI:10.1073/pnas.1600581113 The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids eLife 22 April 2016 DOI: 10
Autophagy (9,391 words) [view diff] exact match in snippet view article find links to article
Kim YM, Jung CH, Seo M, Kim EK, Park JM, Bae SS, Kim DH (January 2015). "mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation"
Grimace scale (animals) (4,344 words) [view diff] exact match in snippet view article
Sorge, R.E., Yan, J., Asiedu, M.N., Valdez, A., ... & Price, T.J. (2013). "mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK"
Immunosenescence (3,759 words) [view diff] exact match in snippet view article find links to article
Macaulay R, Griffiths SJ, et al. (September 2014). "p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells". The Journal of Clinical
Bing Liu (scientist) (778 words) [view diff] exact match in snippet view article
Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1", Frontiers in Pharmacology, 10:191 (2019). doi: 10.3389/fphar.2019.00191
FGF21 (3,109 words) [view diff] exact match in snippet view article find links to article
methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms". FASEB Journal. 32 (6): 3471–3482. doi:10.1096/fj
FGF21 (3,109 words) [view diff] exact match in snippet view article find links to article
methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms". FASEB Journal. 32 (6): 3471–3482. doi:10.1096/fj
Immunosenescence (3,759 words) [view diff] exact match in snippet view article find links to article
Macaulay R, Griffiths SJ, et al. (September 2014). "p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells". The Journal of Clinical
Childhood obesity (8,876 words) [view diff] exact match in snippet view article find links to article
1093/epirev/mxm004. PMID 17566051. Melnik, Bodo C. (2012-01-01). "Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand
DEPDC5 (1,345 words) [view diff] exact match in snippet view article find links to article
GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1". Science. 340 (6136): 1100–6. doi:10.1126/science.1232044. PMC 3728654
Volker Haucke (1,315 words) [view diff] exact match in snippet view article find links to article
Danilo Norata, Marco Falsaca, Carsten Schultz, Volker Haucke (2017-06-02), "mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
Thomas A. Rando (1,389 words) [view diff] exact match in snippet view article find links to article
Namrata; Liu, Ling; Tsai, Chang-Ru; Goodell, Margaret A. (2014-06-19). "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert"
Ageing (16,413 words) [view diff] exact match in snippet view article find links to article
PMID 22442749. Yan L, Lamb RF (August 2012). "Amino acid sensing and regulation of mTORC1". Seminars in Cell & Developmental Biology. 23 (6): 621–5. doi:10.1016/j
Infant formula (9,378 words) [view diff] exact match in snippet view article find links to article
Clinic Specialist" Melnik, Bodo C. (January 1, 2012). "Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand
Tumor metabolome (2,558 words) [view diff] exact match in snippet view article find links to article
Glutaminolysis is linked to cisplatin resistance via the activation of mTORC1 signaling in gastric cancer. NADPH plays an important role as an antioxidant
Ataxia–telangiectasia (10,236 words) [view diff] exact match in snippet view article find links to article
Walker CL (March 2010). "ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS". Proceedings of the National Academy of Sciences of
NEDD4 (3,390 words) [view diff] exact match in snippet view article find links to article
"Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth". Proc. Natl. Acad. Sci. U.S.A. 111
Long non-coding RNA (11,956 words) [view diff] exact match in snippet view article find links to article
Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP (January 2017). "mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide"
Giulio Superti-Furga (1,882 words) [view diff] exact match in snippet view article find links to article
a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015; 519(7544):477-81, doi:10.1038/nature14107. Köberlin, M. et
NEDD4L (3,256 words) [view diff] exact match in snippet view article find links to article
"Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth". Proc. Natl. Acad. Sci. U.S.A. 111
Owen Sansom (1,888 words) [view diff] exact match in snippet view article find links to article
Sonenberg, N; Meyuhas, O; Hall, MN; Bushell, M; Willis, AE; Sansom, OJ (2015). "mTORC1-mediated translational elongation limits intestinal tumour initiation and
Stress granule (12,979 words) [view diff] exact match in snippet view article find links to article
Groen AK, Reth M, Hall MN, Baumeister R (August 2013). "Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells". Cell