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searching for Gene targeting 113 found (167 total)

Cyanidioschyzon (2,347 words) [view diff] exact match in snippet view article find links to article

homologous regions exist for integration. To create a stable mutant line, gene targeting can be used to insert a gene of interest into a particular location

Mario Capecchi (1,969 words) [view diff] case mismatch in snippet view article find links to article

Talk: "The Birth of Gene Targeting" Mario R. Capecchi on Nobelprize.org including the Nobel Lecture on 7 December 2007 Gene Targeting 1977 - Present Eccles

Glabrousness (529 words) [view diff] case mismatch in snippet view article find links to article

Repair of a Defective Glabrous Gene in Arabidopsis With Cas9-Based Gene Targeting". Frontiers in Plant Science. 9: 424. doi:10.3389/fpls.2018.00424. PMC 5895730

Recombinase (757 words) [view diff] exact match in snippet view article find links to article

H; White, BH (Oct 2007). "Combinatorial methods for refined neuronal gene targeting". Current Opinion in Neurobiology. 17 (5): 572–80. doi:10.1016/j.conb

Conditional gene knockout (1,292 words) [view diff] exact match in snippet view article find links to article

are two main strategies to conditional gene knockout and those are gene targeting or homologous recombination and gene trapping. Both methods usually

Insulated neighborhood (2,487 words) [view diff] exact match in snippet view article find links to article

and cohesin at the start and end of the loop that restrict enhancer-gene targeting are "insulated neighborhoods." Insulated neighborhoods are defined as

Coprinopsis cinerea (1,455 words) [view diff] exact match in snippet view article find links to article

increase gene targeting via increased homologous recombination. Either protoplasts derived from oidia or vegetative mycelium can be used, however, gene targeting

Cre-Lox recombination (5,058 words) [view diff] exact match in snippet view article find links to article

reported in 1994 that Cre-lox recombination could be used for conditional gene targeting. They observed ≈50% of the DNA polymerase beta gene was deleted in T

Isogenic human disease models (2,046 words) [view diff] no match in snippet view article find links to article

cells. Isogenic cell lines are created via a process called homologous gene-targeting. Targeting vectors that utilize homologous recombination are the tools

PTPN12 (1,621 words) [view diff] exact match in snippet view article find links to article

Charest A; Wagner J; Tremblay M L (September 1998). "Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases

Fibroblast growth factor 8 (2,175 words) [view diff] exact match in snippet view article find links to article

documented to play a role in oralmaxillogacial diseases and CRISPR-cas9 gene targeting on FGF8 may be key in treating these diseases. Cleft lip and/or palate

Gene knock-in (1,572 words) [view diff] no match in snippet view article find links to article

P. (1997-07-01). "Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice". Current Biology. 7 (7): 530–533. Bibcode:1997CBio

Macular corneal dystrophy (700 words) [view diff] no match in snippet view article find links to article

occur. Various gene therapies, including enzyme replacement therapy and gene-targeting therapy, remain a potential future treatment modality for MCD. Corneal

Guangxi Medical University (620 words) [view diff] exact match in snippet view article find links to article

Wang, Liren; Lu, Xiaoling; Zhao, Yongxiang (2013-08-08). "Heritable gene targeting in the mouse and rat using a CRISPR-Cas system". Nature Biotechnology

Wolf Prize in Medicine (220 words) [view diff] no match in snippet view article find links to article

Kingdom / United States for their contribution to the development of gene-targeting, enabling elucidation of gene function in mice. 2004 Robert A. Weinberg

Selectable marker (818 words) [view diff] exact match in snippet view article find links to article

Scitable. Nature. Retrieved 29 September 2011. Callmigration.org: Gene targeting Jang, Chuan-Wei; Magnuson, Terry (20 February 2013). "A Novel Selection

Jamey Marth (2,477 words) [view diff] exact match in snippet view article find links to article

mutagenesis, the use of homologous recombination was limited to systemic gene targeting and mutation. Marth's use of Cre-Lox conditional mutagenesis established

JARID1B (1,072 words) [view diff] exact match in snippet view article find links to article

Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (August 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation

SKBR3 (363 words) [view diff] exact match in snippet view article find links to article

inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting". Nucleic Acids Research. 44 (19): e149. doi:10.1093/nar/gkw660. PMC 5100567

Collagen, type I, alpha 1 (1,792 words) [view diff] exact match in snippet view article find links to article

JM, Underwood RA, Song KM, Sussman M, Byers PH, Russell DW (2004). "Gene targeting in stem cells from individuals with osteogenesis imperfecta". Science

Hanah Margalit (1,051 words) [view diff] exact match in snippet view article find links to article

Yael; Margalit, Hanah; Mandelboim, Ofer (2007). "Host immune system gene targeting by a viral miRNA". Science. 317 (5836): 376–381. Bibcode:2007Sci...317

Upstream and downstream (transduction) (826 words) [view diff] exact match in snippet view article

Smad 2/3. This leads to the downstream signal cascade and cellular gene targeting. TGF-β regulates multiple downstream processes and cellular functions

NFE2L3 (1,531 words) [view diff] exact match in snippet view article find links to article

(April 2004). "Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus". Molecular and Cellular Biology. 24 (8): 3286–94

Trichome (2,956 words) [view diff] case mismatch in snippet view article find links to article

Repair of a Defective Glabrous Gene in Arabidopsis With Cas9-Based Gene Targeting". Frontiers in Plant Science. 9: 424. doi:10.3389/fpls.2018.00424. PMC 5895730

CD163 (2,166 words) [view diff] exact match in snippet view article find links to article

clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption". Antioxidants & Redox Signaling. 18 (17): 2254–63. doi:10

Dolly (sheep) (2,883 words) [view diff] exact match in snippet view article

not been cloning of animals but in advances into stem cell research. Gene targeting was added in 2000, when researchers cloned female lamb Diana from sheep

Neurturin (1,477 words) [view diff] exact match in snippet view article find links to article

Molliver DC, Bardgett ME, Snider WD, Johnson EM, Milbrandt J (Feb 1999). "Gene targeting reveals a critical role for neurturin in the development and maintenance

Toll-like receptor (6,771 words) [view diff] exact match in snippet view article find links to article

the TLRs, ligand recognition specificity has now been established by gene targeting (also known as "gene knockout"): a technique by which individual genes

Muscular Dystrophy Canada (535 words) [view diff] case mismatch in snippet view article find links to article

2011-10-02. Retrieved 2011-06-21. "New Scientific Director Transgenic and Gene Targeting Facility - Schulich School of Medicine & Dentistry". Archived from the

Ribonuclease P (2,315 words) [view diff] no match in snippet view article find links to article

Trang P, Kim K, Liu F (June 2004). "Developing RNase P ribozymes for gene-targeting and antiviral therapy". Cellular Microbiology. 6 (6): 499–508. doi:10

LECT1 (708 words) [view diff] exact match in snippet view article find links to article

isolated from cartilage, is abundantly expressed in cardiac valves. Gene targeting of chondromodulin-I resulted in enhanced VEGF-A expression, angiogenesis

Group II intron (1,854 words) [view diff] exact match in snippet view article find links to article

J, Lambowitz AM (December 2001). "Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria". Nat Biotechnol. 19 (12):

Metabotropic glutamate receptor 1 (2,342 words) [view diff] exact match in snippet view article find links to article

receptor 1 were reported in 1994. By homologous recombination mediated gene targeting those mice became deficient in mGlu receptor 1 protein. The mice did

DNA-binding protein (2,633 words) [view diff] exact match in snippet view article find links to article

KJ, Voytas DF, Ekker SC (September 2011). "A TALE of two nucleases: gene targeting for the masses?". Zebrafish. 8 (3): 147–9. doi:10.1089/zeb.2011.9993

HS2ST1 (508 words) [view diff] exact match in snippet view article find links to article

in development, immune response and tissue functions, as revealed by gene targeting". J. Biochem. 127 (2): 171–6. doi:10.1093/oxfordjournals.jbchem.a022590

EPR1 (544 words) [view diff] exact match in snippet view article find links to article

"Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting". J. Biol. Chem. 273 (18): 11177–82. doi:10.1074/jbc.273.18.11177. PMID 9556606

Psymberin (411 words) [view diff] exact match in snippet view article find links to article

assembly lines of uncultivated sponge symbionts from structure-based gene targeting". Nat. Chem. Biol. 5 (7): 494–501. doi:10.1038/nchembio.176. PMID 19448639

ARID5B (641 words) [view diff] exact match in snippet view article find links to article

Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation

CD97 (3,290 words) [view diff] exact match in snippet view article find links to article

"Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration". Journal of Immunology. 181 (9): 6574–83

Terence Rabbitts (675 words) [view diff] exact match in snippet view article find links to article

developed the first knock-in gene, now a widely employed approach in gene targeting and gene editing. He also pioneered the design of intracellular antibody

HNRNPC (1,580 words) [view diff] exact match in snippet view article find links to article

T, Irmler M, Beckers J, Chen H, Adams JS, Hewison M (March 2011). "Gene targeting by the vitamin D response element binding protein reveals a role for

Jian-Kang Zhu (2,374 words) [view diff] exact match in snippet view article find links to article

using TALE nucleases and CRISPR/Cas. They developed the first efficient gene targeting method for the model plant Arabidopsis. They have also developed an

Caliper Life Sciences (717 words) [view diff] exact match in snippet view article find links to article

a CRO offering in vivo transgenic animal production, phenotyping, gene targeting and in vivo optical imaging services, which was subsequently acquired

Matthew Porteus (197 words) [view diff] exact match in snippet view article find links to article

Porteus MH, Baltimore D (May 2003). "Chimeric nucleases stimulate gene targeting in human cells". Science. 300 (5620): 763. doi:10.1126/science.1078395

Immediate early gene (1,965 words) [view diff] no match in snippet view article find links to article

expression through antisense oligonucleotides, RNA interference, and gene-targeting ribosomes have been investigated for therapeutic applications. Alternatively

Moss (6,979 words) [view diff] exact match in snippet view article find links to article

Nogué F (April 2012). "MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens". Nucleic Acids Res. 40 (8): 3496–510

Beatrice Mintz (1,546 words) [view diff] exact match in snippet view article find links to article

doi:10.1073/pnas.71.4.1250. PMC 388203. PMID 4364530. Soriano P (1995). "Gene targeting in ES cells". Annu Rev Neurosci. 18: 1–18. doi:10.1146/annurev.ne.18

Ca2+/calmodulin-dependent protein kinase II (3,458 words) [view diff] exact match in snippet view article find links to article

1016/S0092-8674(00)81829-2. PMID 8980240. S2CID 16704390. Tonegawa S (1994). "Gene targeting: a new approach for the analysis of mammalian memory and learning".

Chimeraplasty (264 words) [view diff] exact match in snippet view article find links to article

; Engelhardt, John F. (February 2003). "Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay". Molecular Therapy

Hyaluronidase (3,092 words) [view diff] no match in snippet view article find links to article

digesting hyaluronan in the corona radiata, thus enabling conception. Gene-targeting studies show that hyaluronidases such as PH20 are not essential for

Lactobacillus delbrueckii subsp. bulgaricus (2,490 words) [view diff] exact match in snippet view article find links to article

in a timely manner through the use of qPCR. Two essays using lacZ gene targeting PCR primers resulted from this study and were deemed compatible with

Colworth Medal (1,714 words) [view diff] exact match in snippet view article find links to article

1042/bst0200243. PMID 1397606. S2CID 7796865. Melton, D. W. (1990). "The use of gene targeting to develop animal models for human genetic diseases". Biochemical Society

Citrus greening disease (3,260 words) [view diff] no match in snippet view article find links to article

Hunter, Wayne (2017). "FANA and Morpholino's, Novel Molecules for Gene-Targeting in Plants and Arthropods". Proceedings of the XXV International Plant

Neurofilament light polypeptide (2,166 words) [view diff] exact match in snippet view article find links to article

1074/jbc.M207211200. PMID 12226091. Hirokawa N, Takeda S (October 1998). "Gene targeting studies begin to reveal the function of neurofilament proteins". The

Transcription activator-like effector nuclease (3,148 words) [view diff] exact match in snippet view article find links to article

P, Xiao A, Zhou M, Zhu Z, Lin S, Zhang B (August 2011). "Heritable gene targeting in zebrafish using customized TALENs". Nature Biotechnology. 29 (8):

Red flour beetle (2,405 words) [view diff] exact match in snippet view article find links to article

Gilles, A. Schinko, J. Averof, M. 2015. Efficient CRISPR-mediated gene targeting and transgene replacement in the beetle Tribolium castaneum. Development

Tyler Jacks (1,105 words) [view diff] no match in snippet view article find links to article

of the most difficult to treat cancers. He has pioneered the use of gene-targeting technology in mice to study cancer-associated genes and to construct

Intracellular delivery (8,788 words) [view diff] exact match in snippet view article find links to article

(B-Cell ALL), produced through ex vivo lentiviral gene delivery of a CAR gene targeting CD-19 (US approval granted 2017). Axicabtagene Ciloleucel (branded as

Alexander Fleming Biomedical Sciences Research Center (657 words) [view diff] exact match in snippet view article find links to article

Flow Cytometry Facility, a Protein Chemistry Lab, a Transgenics and gene targeting Unit, and a BioIT Unit, all of which serve internal collaborations,

Kyoto Prize in Basic Sciences (513 words) [view diff] case mismatch in snippet view article find links to article

States born 1937 Production of Knockout Mice through the Development of Gene Targeting Technique and Outstanding Contribution to Elucidation of Gene Function

Tissue-agnostic cancer drug (597 words) [view diff] case mismatch in snippet view article find links to article

type". NBC. Retrieved 17 Dec 2018. Wang, Brian (June 19, 2019). "New Gene Targeting Cancer Drugs And Other Advances in Cancer Medicine – NextBigFuture.com"

Magnetic resonance imaging (10,737 words) [view diff] exact match in snippet view article find links to article

agents or MRI contrast agents with high relaxivities. A new class of gene targeting MR contrast agents has been introduced to show gene action of unique

Wim Crusio (3,032 words) [view diff] case mismatch in snippet view article find links to article

A (February 2001). Routtenberg A, Crusio WE (eds.). "Special Issue: Gene Targeting and Hippocampal Function". Hippocampus. 12 (1): 2–3. doi:10.1002/hipo

Xenbase (1,600 words) [view diff] exact match in snippet view article find links to article

Biotech 29(2): 135-136 Huang, P., A. Xiao, et al. (2011). "Heritable gene targeting in zebrafish using customized TALENs." Nat Biotech 29(8): 699-700

Gene (12,541 words) [view diff] exact match in snippet view article find links to article

ISBN 9780124047426. PMC 3683964. PMID 23084873. Puchta H, Fauser F (2013). "Gene targeting in plants: 25 years later". The International Journal of Developmental

Mahendra Rao (369 words) [view diff] case mismatch in snippet view article find links to article

research appointment in NIAMS and NINDS. Liu, Ying; Rao, Mahendra (2011). Gene Targeting in Human Pluripotent Stem Cells. Methods in Molecular Biology. Vol. 767

Multiple myeloma (13,509 words) [view diff] exact match in snippet view article find links to article

trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target". Oncotarget.

HPN (gene) (827 words) [view diff] exact match in snippet view article

12 (12): 5052–9. doi:10.2741/2447. PMID 17569629. Wu Q (Feb 2001). "Gene targeting in hemostasis. Hepsin". Frontiers in Bioscience. 6 (3): D192-200. doi:10

Magnaporthe grisea (3,532 words) [view diff] exact match in snippet view article find links to article

PMID 35635051. Zhou, Junhui; Peng, Zhao; Long, Juying; et al. (2015). "Gene targeting by the TAL effector PthXo2 reveals cryptic resistance gene for bacterial

Bachmann-Bupp syndrome (835 words) [view diff] no match in snippet view article find links to article

testing and comprehensive genomic testing depending on the phenotype. The gene-targeting testing will sequence the ODC1 gene to detect small intragenic deletions

Transcription activator-like effector (2,796 words) [view diff] exact match in snippet view article find links to article

P, Xiao A, Zhou M, Zhu Z, Lin S, Zhang B (August 2011). "Heritable gene targeting in zebrafish using customized TALENs". Nature Biotechnology. 29 (8):

Sickle cell disease (14,947 words) [view diff] exact match in snippet view article find links to article

Washington G, Nicolas CE, et al. (November 2016). "CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells". Nature. 539 (7629): 384–389. Bibcode:2016Natur

Extrachromosomal DNA (5,349 words) [view diff] exact match in snippet view article find links to article

Dallapiccola B (June 2002). "Extrachromosomal genes: a powerful tool in gene targeting approaches". Gene Therapy. 9 (11): 679–82. doi:10.1038/sj.gt.3301749

Site-specific recombination (2,034 words) [view diff] case mismatch in snippet view article find links to article

from the original (PDF) on 2006-08-29. Sauer, B. (1998). "Inducible Gene Targeting in Mice Using the Cre/loxSystem" (PDF). Methods. 14 (4): 381–92. doi:10

Arabidopsis thaliana (8,664 words) [view diff] case mismatch in snippet view article find links to article

Mantegazza O, Weber AP (5 April 2018). "Arabidopsis With Cas9-Based Gene Targeting". Frontiers in Plant Science. 9: 424. doi:10.3389/fpls.2018.00424. PMC 5895730

David Baltimore (8,318 words) [view diff] exact match in snippet view article find links to article

Porteus MH, Baltimore D (May 2003). "Chimeric nucleases stimulate gene targeting in human cells". Science. 300 (5620): 763. doi:10.1126/science.1078395

Diaphorina citri (3,356 words) [view diff] no match in snippet view article find links to article

2024-05-17 Hunter, Wayne (2017). "FANA and Morpholino's, Novel Molecules for Gene-Targeting in Plants and Arthropods". Proceedings of the XXV International Plant

Daniel Voytas (784 words) [view diff] exact match in snippet view article find links to article

D.F. (2013) Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways. Genome Res. 23:

Human genetic enhancement (10,149 words) [view diff] exact match in snippet view article find links to article

CRISPR/Cas9 reduces the time required to modify target genes compared to gene targeting technologies that rely on the use of embryonic stem (ES) cells. Bioinformatics

Burzynski Clinic (6,927 words) [view diff] no match in snippet view article find links to article

that the Burzynski clinic would indeed be able to actually personalise gene-targeting therapies, i.e., "identify who would benefit from specific targeted

E. Dale Abel (957 words) [view diff] exact match in snippet view article find links to article

studied how glucose is delivered to cells. He made use of conditional gene targeting to induce genetic defects that resulted in heart muscle cells being

RAD52 (3,013 words) [view diff] exact match in snippet view article find links to article

Porter AC (Feb 2002). "Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line"

Rosetta@home (8,602 words) [view diff] exact match in snippet view article find links to article

Ranson H, Burt A, Crisanti A (2007). "Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos". Nucleic Acids Research. 35

I-CreI (1,374 words) [view diff] exact match in snippet view article find links to article

This specificity of I-CreI cleavage makes I-CreI a promising tool for gene targeting. If a person were to have a disease due to a defective allele of some

Jennifer Loros (1,273 words) [view diff] case mismatch in snippet view article find links to article

and V. Meyer. (8 March 2017). "HisB as Novel Selection Marker for Gene Targeting Approaches in Aspergillus Niger". BMC Microbiology. 17 (1): 57. doi:10

Genes to Cognition Project (488 words) [view diff] exact match in snippet view article find links to article

further investigation, G2C has undertaken to knock out many of these by gene targeting in mice and has established a number of high-throughput platforms for

Nissim Benvenisty (1,672 words) [view diff] exact match in snippet view article find links to article

Maya; Benvenisty, Nissim (2004). "Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells". Stem Cells. 22 (4): 635–641. doi:10

Charlotte Sumner (651 words) [view diff] exact match in snippet view article find links to article

Atrophy Disease Mechanisms and Therapy. As part of a commitment to make gene targeting therapeutics accessible throughout the world, she chairs the Spinraza

Recombinant AAV mediated genome engineering (2,673 words) [view diff] exact match in snippet view article find links to article

"Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells". Proc. Natl. Acad. Sci. U.S.A. 105 (25): 8703–8

Herpes simplex research (8,781 words) [view diff] no match in snippet view article find links to article

ocular infection in rabbits, and reduced the viral yield in vivo. The gene-targeting approach uses a specially designed RNA enzyme to inhibit strains of

Endocrine disruptor (17,094 words) [view diff] case mismatch in snippet view article find links to article

Cavalheiro GR, Matos-Rodrigues GE, Martins RA (August 2015). "From Gene Targeting to Genome Editing: Transgenic animals applications and beyond". Anais

Sleeping Beauty transposon system (2,762 words) [view diff] exact match in snippet view article find links to article

Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM (December 2010). "Gene targeting in the rat: advances and opportunities". Trends in Genetics. 26 (12):

Serpin (14,301 words) [view diff] exact match in snippet view article find links to article

lung and liver transplantation has proven effective. In animal models, gene targeting in induced pluripotent stem cells has been successfully used to correct

He Jiankui affair (12,426 words) [view diff] exact match in snippet view article find links to article

"Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos". Cell. 156 (4): 836–843. doi:10.1016/j.cell.2014

CRISPR gene editing (19,890 words) [view diff] exact match in snippet view article find links to article

Washington G, Nicolas CE, et al. (November 2016). "CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells". Nature. 539 (7629): 384–389. Bibcode:2016Natur

HPG80 (5,038 words) [view diff] no match in snippet view article find links to article

treatment in colorectal cancer patients with a mutation in the KRAS gene. Targeting of hPG80 with the humanized anti-hPG80 antibody has been shown: 1.

CD4+ T cells and antitumor immunity (4,000 words) [view diff] exact match in snippet view article find links to article

proteins, the CIITA or class II transcription activator. Selective gene targeting of CIITA has been used ex vivo to allow MHC class II− cells to become

Preclinical imaging (6,058 words) [view diff] exact match in snippet view article find links to article

This also allows the identification of mechanisms for tissue-selective gene targeting in cancer and beyond. Principle: Dioxaborolane chemistry enables radioactive

Zinc finger nuclease treatment of HIV (3,400 words) [view diff] exact match in snippet view article find links to article

expression of these proteins to avoid ‘off-target’ effects. v) During gene targeting, genotoxicity associated with high expression of ZFNs might lead to

Survivin (8,391 words) [view diff] exact match in snippet view article find links to article

"Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting". J. Biol. Chem. 273 (18): 11177–82. doi:10.1074/jbc.273.18.11177. PMID 9556606

Timeline of biotechnology (24,501 words) [view diff] no match in snippet view article find links to article

bioRxiv: 2020.03.13.991307. doi:10.1101/2020.03.13.991307. "Scientists aim gene-targeting breakthrough against COVID-19". phys.org. Archived from the original

Selfish genetic element (10,203 words) [view diff] exact match in snippet view article find links to article

editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon". Nature Protocols. 8 (10): 2061–78. doi:10

Melanie Greter (2,494 words) [view diff] exact match in snippet view article find links to article

nervous system. They further used the Sall1 locus for microglia-specific gene targeting and they found that inactivating the Sall1 locus led microglia to transition

Ocular albinism late onset sensorineural deafness (2,300 words) [view diff] exact match in snippet view article find links to article

knockout mice with inactivated OA1 genes. OA1 gene was made inactive with gene targeting technique. Ultrastructural analysis was performed on the melanosomes

Steven M. Reppert (4,234 words) [view diff] no match in snippet view article find links to article

Christine Merlin and Scot Wolfe developed in Reppert’s lab a novel gene-targeting approach in monarchs that uses a zinc finger nuclease strategy to define

Pullulan bioconjugate (3,019 words) [view diff] exact match in snippet view article find links to article

"Pullulan and pullulan derivatives as promising biomolecules for drug and gene targeting". Carbohydrate Polymers. 123: 190–207. doi:10.1016/j.carbpol.2015.01

List of female Clarivate Citation laureates (308 words) [view diff] exact match in snippet view article find links to article

(born 1972) United States "for the development of innovative drug and gene targeting and delivery methods." (selected with Vladimir Torchilin and Kazunori

No-SCAR genome editing (5,650 words) [view diff] exact match in snippet view article find links to article

severe combined immunodeficiency and correction by CRISPR/Cas9-enhanced gene targeting". Cell Reports. 12 (10): 1668–77. doi:10.1016/j.celrep.2015.08.013.

Embryonal fyn-associated substrate (4,850 words) [view diff] exact match in snippet view article find links to article

Côté JF, Charest A, Wagner J, Tremblay ML (Sep 1998). "Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases

List of Clarivate Citation laureates in Chemistry (342 words) [view diff] exact match in snippet view article find links to article

Kataoka (born 1950) Japan "for the development of innovative drug and gene targeting and delivery methods." University of Tokyo Vladimir P. Torchilin (born

Genome-wide CRISPR-Cas9 knockout screens (6,172 words) [view diff] exact match in snippet view article find links to article

made CRISPR the platform of choice for many researchers engaging in gene targeting and editing. The clustered regularly interspaced short palindrome repeats

List of taxa that use parthenogenesis (4,670 words) [view diff] exact match in snippet view article find links to article

Agriculture used parthenogenesis to create a fatherless mouse. Using gene targeting, they were able to manipulate two imprinted loci H19/IGF2 and DLK1/MEG3

January–March 2020 in science (20,060 words) [view diff] no match in snippet view article find links to article

and influenza". bioRxiv 10.1101/2020.03.13.991307. "Scientists aim gene-targeting breakthrough against COVID-19". phys.org. Retrieved 13 June 2020. Abbott