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Find link is a tool written by Edward Betts.Longer titles found: Directed evolution (transhumanism) (view)
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ISSN 0305-0270. Askland, Andrew (2011). "The Misnomer of Transhumanism as Directed Evolution" (PDF). International Journal of Emerging Technologies and SocietyBryan Roth (726 words) [view diff] exact match in snippet view article find links to article
identification of new probes and tools to detect GPCRs, obtained through directed evolution in animal cells, developing receptors activated solely by a syntheticRibosome display (966 words) [view diff] exact match in snippet view article find links to article
be transformed after any diversification step. This allows facile directed evolution of binding proteins over several generations. A prerequisite for theTheodor Eimer (817 words) [view diff] exact match in snippet view article find links to article
German zoologist. He was a popularizer of orthogenesis, a form of directed evolution through mutations that made use of Lamarckian principles. Eimer wasThreose nucleic acid (1,216 words) [view diff] exact match in snippet view article find links to article
incoming TNA nucleotide triphosphate and support the need for further directed evolution experiments to create TNA polymerases with improved activity. TheMonobody (1,510 words) [view diff] exact match in snippet view article find links to article
portions of the FN3 scaffold are diversified using molecular display and directed evolution technologies such as phage display, mRNA display and yeast surfaceHuimin Zhao (271 words) [view diff] exact match in snippet view article find links to article
Carl R. Woese Institute for Genomic Biology. His research focuses on directed evolution, metabolic engineering, bioinformatics and high throughput technologiesOncolytic adenovirus (4,209 words) [view diff] exact match in snippet view article find links to article
currently in development is ColoAd1. It was created using a process of “directed evolution”. This involves the creation of new viral variants or serotypes specificallyNicholas Turner (chemist) (1,057 words) [view diff] exact match in snippet view article
His group combine enzyme discovery with protein engineering and directed evolution methods in order to develop biocatalysts with tailored propertiesSNAP-tag (1,001 words) [view diff] exact match in snippet view article find links to article
O-6-methylguanine-DNA methyltransferase (MGMT) gene. SNAP-tag was obtained using a directed evolution strategy, leading to a hAGT variant that accepts O6-benzylguanineMolecular genetics (3,815 words) [view diff] case mismatch in snippet view article find links to article
Retrieved 2023-10-16. "Selection versus Screening in Directed Evolution", Directed Evolution of Selective Enzymes, John Wiley & Sons, Ltd, 2016, ppMulticellular organism (4,856 words) [view diff] exact match in snippet view article find links to article
identified by directed evolution. More recently (2024), snowflake yeast were subject to over 3,000 generations of further directed evolution, forming macroscopicGeorge I. Mavrodes (516 words) [view diff] exact match in snippet view article find links to article
understanding of evolution holds that although evolution occurred, God still directed evolution. Evolution is merely the tool of God's design. Evolution, and evenSite-directed mutagenesis (2,980 words) [view diff] exact match in snippet view article find links to article
Steinberg, Barrett E. (16 April 2020). "SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4):In vitro compartmentalization (2,195 words) [view diff] exact match in snippet view article find links to article
007. PMID 17055094. Ghadessy FJ, Ong JL, Holliger P (April 2001). "Directed evolution of polymerase function by compartmentalized self-replication". ProceedingsUlrich Schwaneberg (839 words) [view diff] exact match in snippet view article find links to article
Institute for Interactive Materials in Aachen. He specializes in directed evolution of proteins for material science applications and on the developmentTheistic evolution (7,509 words) [view diff] exact match in snippet view article find links to article
different positions from the 1890s to the 1920s: "Orthogenesis" (goal-directed evolution), "nomogenesis" (evolution according to fixed law), "emergent evolution"Invertebrate (5,002 words) [view diff] exact match in snippet view article find links to article
and vertebrates were closer than invertebrates were. Although goal-directed evolution has been abandoned, the distinction of invertebrates and vertebratesBeta-2 microglobulin (2,118 words) [view diff] case mismatch in snippet view article find links to article
HLA-G 2esv: Structure of the HLA-E-VMAPRTLIL/KK50.4 TCR complex 2f53: Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramaticallyEdward F. Fritsch (709 words) [view diff] no match in snippet view article find links to article
(EPO) gene. Fritsch then joined Phylos, Inc. to utilize a in vitro, directed-evolution technology to discover new protein therapeutics, eventually becomingGaia hypothesis (9,256 words) [view diff] case mismatch in snippet view article find links to article
hypothesis has been called "influential Gaia" in the 2002 paper "Directed Evolution of the Biosphere: Biogeochemical Selection or Gaia?" by Andrei G.Β-Galactosidase (3,025 words) [view diff] exact match in snippet view article find links to article
1981). "Changes in the substrate specificities of an enzyme during directed evolution of new functions". Biochemistry. 20 (14): 4042–9. doi:10.1021/bi00517a015Michael Denton (742 words) [view diff] exact match in snippet view article find links to article
of organisms; he has proposed an evolutionary theory which is a "directed evolution" in his book Nature's Destiny (1998). Life, according to Denton, didBaeyer–Villiger oxidation (2,601 words) [view diff] case mismatch in snippet view article find links to article
Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution". Journal of the American Chemical Society. 140 (33): 10464–10472Fluorescence-activating and absorption-shifting tag (1,763 words) [view diff] exact match in snippet view article find links to article
protein, was engineered from the photoactive yellow protein (PYP) by directed evolution. It was disclosed for the first time in 2016 by researchers from EcoleAeropyrum pernix (637 words) [view diff] exact match in snippet view article find links to article
of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering Design & Selection. 17 (11): 771–777. doi:102-Dehydro-3-deoxy-phosphogluconate aldolase (1,633 words) [view diff] case mismatch in snippet view article find links to article
amino acid sequences yet analogous symmetrical structure and folding. Directed Evolution KDPG aldolase has limited utility due to its high specificity forBroad Institute (2,662 words) [view diff] exact match in snippet view article find links to article
Institute, the inventor of DNA-templated synthesis, phage-assisted directed evolution and Cas9/CRISPR base-editing. Stuart Schreiber is director of theCambridge Antibody Technology (8,513 words) [view diff] exact match in snippet view article find links to article
L; Minter, RR (2006). "Probing a protein-protein interaction by directed evolution". Proc Natl Acad Sci USA. 103 (20): 7619–24. Bibcode:2006PNAS..103HLA-A (3,411 words) [view diff] case mismatch in snippet view article find links to article
PEPTIDE EXTENDING OUT ONE END OF A CLASS I MHC BINDING SITE 2f53: Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramaticallyInositol oxygenase (1,818 words) [view diff] exact match in snippet view article find links to article
numerous strategies including appendage of an N-terminal SUMO-tag, directed evolution and also the use of modular, synthetic scaffolds to increase its effectiveEnzyme (10,086 words) [view diff] exact match in snippet view article find links to article
Eggert T (August 2004). "Enantioselective biocatalysis optimized by directed evolution". Current Opinion in Biotechnology. 15 (4): 305–313. doi:10.1016/jCope's rule (1,976 words) [view diff] exact match in snippet view article find links to article
this is usually a result of size varying pseudo-randomly rather than directed evolution. This does not fall into Cope's rule sensu stricto, but is consideredDNA methyltransferase (3,598 words) [view diff] exact match in snippet view article find links to article
recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution". Journal of Molecular Biology. 395 (1): 79–88. doi:10.1016/j.jmbAcetoacetyl-CoA (879 words) [view diff] exact match in snippet view article find links to article
Watanabe T, Motohashi R, Ikeda K, Tobitani K, et al. (October 2013). "Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme AStructuralism (biology) (2,365 words) [view diff] exact match in snippet view article
developmental constraints, led (solid blue arrows) to some form of directed evolution (orthogenesis), with or without invoking divine control (dotted blueJane Glazebrook (748 words) [view diff] case mismatch in snippet view article find links to article
Casim. (February 2017-February 2019). Engineering Plant Immunity via Directed Evolution of Imm. USDA National Institute of Food & Agriculture. Glazebook,MRC Laboratory of Molecular Biology (3,821 words) [view diff] exact match in snippet view article find links to article
PMID 23741620. World2018-10-03T11:06:00+01:00, Chemistry. "Live blog: directed evolution takes chemistry Nobel prize". Chemistry World. Retrieved 23 FebruaryIslamic views on evolution (4,460 words) [view diff] no match in snippet view article find links to article
acceptance, albeit divinely designed. The movement actively promotes God-directed "evolution". Over the course of several decades the movement issued variousChristian fundamentalism (7,999 words) [view diff] exact match in snippet view article find links to article
the Bible, and others were comfortable teaching some forms of God-directed evolution. Riley and the more strident fundamentalists, however, associatedEdward Boyden (3,444 words) [view diff] exact match in snippet view article find links to article
Shemesh, Or; Asano, Shoh (April 2018). "A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters". Nature ChemicalCarl Nägeli (1,031 words) [view diff] exact match in snippet view article find links to article
Darwinism. He developed an "inner perfecting principle" which he believed directed evolution. He wrote that many evolutionary developments were nonadaptive andVirus (18,323 words) [view diff] exact match in snippet view article find links to article
A particular quality of viruses is that they can be tailored by directed evolution. The powerful techniques developed by life sciences are becoming theHemoprotein (2,454 words) [view diff] exact match in snippet view article find links to article
Schneider P, Vind J, Svendsen A, Jones A, Pedersen AH (April 1999). "Directed evolution of a fungal peroxidase". Nature Biotechnology. 17 (4): 379–384. doi:10Carbonic anhydrase (4,361 words) [view diff] exact match in snippet view article find links to article
CK, Bresson JA, Lakhapatri SL, Solis EO, et al. (November 2014). "Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon captureHigh-throughput screening (4,314 words) [view diff] exact match in snippet view article find links to article
Mazaleyrat, S. L. (2007). "Development of a screening platform for directed evolution using the reef coral fluorescent protein ZsGreen as a solubility reporter"SeSaM-Biotech GmbH (882 words) [view diff] exact match in snippet view article find links to article
Retrieved April 24, 2017. Cheng, F.; Zhu, L.; Schwaneberg, U. (2015). "Directed evolution 2.0: improving and deciphering enzyme properties" (PDF). Chem. CommunPyrococcus woesei (317 words) [view diff] exact match in snippet view article find links to article
Ai-Sheng; Peng, Ri-He; Zhuang, Jing; Li, Xian; et al. (18 Sep 2007). "Directed evolution of a beta-galactosidase from Pyrococcus woesei resulting in increasedKarl Ernst von Baer (2,914 words) [view diff] exact match in snippet view article find links to article
organisms. Baer believed in a teleological force in nature which directed evolution (orthogenesis). The term Baer's law is also applied to the unconfirmedAdeno-associated virus (8,624 words) [view diff] exact match in snippet view article find links to article
another strain. For example: Mixing AAV2 and AAV5, then undergoing directed evolution, can produce a virus that targets the respiratory tract. AAV2/5, aTranscription activator-like effector nuclease (3,148 words) [view diff] exact match in snippet view article find links to article
PMID 17603476. S2CID 22079561. Guo J, Gaj T, Barbas CF (July 2010). "Directed evolution of an enhanced and highly efficient FokI cleavage domain for zincGreen fluorescent protein (7,622 words) [view diff] case mismatch in snippet view article find links to article
PMC 5007177. PMID 27479328. Mattson S, Tran GN, Rodriguez EA (2023). "Directed Evolution of Fluorescent Proteins in Bacteria". In Sharma M (ed.). FluorescentNeutral network (evolution) (2,832 words) [view diff] exact match in snippet view article
L; Kast, P; van Gunsteren, WF; Marlière, P; Hilvert, D (2013). "Directed evolution of a model primordial enzyme provides insights into the developmentYersinia mollaretii (177 words) [view diff] exact match in snippet view article find links to article
Roccatano, Danilo; Haefner, Stefan; Schwaneberg, Ulrich (2011). "Directed evolution of a highly active Yersinia mollaretii phytase". Applied MicrobiologyPhytoene desaturase (neurosporene-forming) (217 words) [view diff] exact match in snippet view article
product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution". The Journal of Biological Chemistry. 276 (44): 41161–4. doi:10.1074/jbcOn the Origin of Species (18,868 words) [view diff] exact match in snippet view article find links to article
tried to meet these objections in the fifth edition. Mivart supported directed evolution, and compiled scientific and religious objections to natural selectionAlfred Russel Wallace (14,361 words) [view diff] exact match in snippet view article find links to article
commented that this anticipated ideas about design in nature and directed evolution that would arise from religious traditions throughout the 20th centuryXeno nucleic acid (2,629 words) [view diff] case mismatch in snippet view article find links to article
Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution". Biomolecules. 10 (12): 1647. doi:10.3390/biom10121647. ISSN 2218-273XGeranylfarnesyl diphosphate synthase (249 words) [view diff] exact match in snippet view article find links to article
of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering, Design & Selection. 17 (11): 771–7. doi:10PON3 (901 words) [view diff] exact match in snippet view article find links to article
1038/nature01782. PMID 12853948. Aharoni A, Gaidukov L, Yagur S, et al. (2004). "Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression andHalohydrin dehalogenase (969 words) [view diff] exact match in snippet view article find links to article
dehalogenase from Arthrobacter sp. strain AD2, revealed by structure-guided directed evolution". Appl Environ Microbiol. 78 (8): 4051–4056. Bibcode:2012ApEnM..78Irish elk (6,884 words) [view diff] exact match in snippet view article find links to article
with smaller antlers, was taken as a prime example of orthogenesis (directed evolution), an evolutionary mechanism opposed to Darwinian evolution in whichDiapolycopene oxygenase (153 words) [view diff] exact match in snippet view article find links to article
synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution". Chemistry & Biology. 12 (4): 453–60. doi:10.1016/j.chembiol.2005Mosaic protein (620 words) [view diff] exact match in snippet view article find links to article
S2CID 24447528. Kolkman, Joost A.; Stemmer, Willem P. C. (2001-05-01). "Directed evolution of proteins by exon shuffling". Nature Biotechnology. 19 (5): 423–428Bicyclobutane (726 words) [view diff] exact match in snippet view article find links to article
Anabaena sphaerica (strain PCC 7120). The other group reported a directed evolution approach, whereby engineered heme protein was expressed in E. coliAlternatives to Darwinian evolution (5,862 words) [view diff] exact match in snippet view article find links to article
arrows). Many of these theories led (blue arrows) to some form of directed evolution (orthogenesis), with or without invoking divine control (dotted blueMicrobial genetics (5,154 words) [view diff] exact match in snippet view article find links to article
method of production is the ability to direct optimization by means of directed evolution. The efficiency and specificity of production will increase over timeRobustness (evolution) (4,629 words) [view diff] exact match in snippet view article
Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D (2013). "Directed evolution of a model primordial enzyme provides insights into the developmentAscorbate peroxidase (1,255 words) [view diff] exact match in snippet view article find links to article
KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY (January 2015). "Directed evolution of APEX2 for electron microscopy and proximity labeling". Nature MethodsCircular permutation in proteins (3,511 words) [view diff] exact match in snippet view article find links to article
96.20.11241. PMC 18018. PMID 10500161. Turner NJ (August 2009). "Directed evolution drives the next generation of biocatalysts". Nature Chemical BiologyAlkalihalobacillus alcalophilus (367 words) [view diff] exact match in snippet view article find links to article
of cold adaptation of Bacillus alcalophilus alkaline protease by directed evolution". Journal of Molecular Catalysis B: Enzymatic. 106: 117–123. doi:10Microbiome (11,925 words) [view diff] exact match in snippet view article find links to article
PMC 4575871. PMID 26109480. Bloom JD, Arnold FH (2009). "In the light of directed evolution: Pathways of adaptive protein evolution". Proceedings of the NationalCas9 (5,898 words) [view diff] exact match in snippet view article find links to article
JK, Jeong E, Lee J, Jung M, Shin E, Kim YH, et al. (August 2018). "Directed evolution of CRISPR-Cas9 to increase its specificity". Nature CommunicationsDeoxyribozyme (4,676 words) [view diff] exact match in snippet view article find links to article
1073/pnas.0305943101. PMC 314139. PMID 14691255. Joyce GF (2004). "Directed evolution of nucleic acid enzymes". Annual Review of Biochemistry. 73 (1): 791–836Zero-shot learning (1,392 words) [view diff] case mismatch in snippet view article find links to article
Yisong; Arnold, Frances H. (2020-12-04). "Machine Learning-Assisted Directed Evolution Navigates a Combinatorial Epistatic Fitness Landscape with MinimalList of biophysicists (2,538 words) [view diff] exact match in snippet view article find links to article
reactions of photosynthesis, genetic code, imaging spectroscopy and directed evolution Bruno Zimm — co-developer of the Zimm-Bragg model of helix formationMichael Fischbach (1,243 words) [view diff] exact match in snippet view article find links to article
Institutions Stanford University Thesis Nonribosomal peptide biosynthesis: Directed evolution of assembly line enzymes and characterization of post-assembly lineFerdinand Bohlmann (398 words) [view diff] case mismatch in snippet view article find links to article
California Institute of Technology United States Manfred T. Reetz 2004 Directed Evolution of Enantioselective Enzymes Max-Planck-Institut für KohlenforschungExon shuffling (2,249 words) [view diff] exact match in snippet view article find links to article
PMID 14634634. S2CID 33999892. Kolkman JA, Stemmer WP (May 2001). "Directed evolution of proteins by exon shuffling". Nature Biotechnology. 19 (5): 423–428HKA test (833 words) [view diff] case mismatch in snippet view article find links to article
Example of Directed Evolution - SelectionEvidence of common descent (27,677 words) [view diff] exact match in snippet view article find links to article
such as proteins." Evolutionary molecular engineering, also called directed evolution or in vitro molecular evolution involves the iterated cycle of mutationDouglas Kell (3,219 words) [view diff] exact match in snippet view article find links to article
Swainston, N; Day, PJ; Kell, DB (2015). "Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently"Wolfgang Schad (723 words) [view diff] case mismatch in snippet view article find links to article
Vegetation in the Bergisch-Märkische Hügelland Wirz, Johannes (2014). "Directed Evolution: Commentary on Wolfgang Schad's Archäopteryx lithographica – eineEnadenotucirev (372 words) [view diff] case mismatch in snippet view article find links to article
ongoing clinical study. Oncolytic adenovirus Oncolytic adenovirus#Directed Evolution "Enadenotucirev". PsiOxus Therapeutics. Retrieved 2019-07-04. MachielsValery Taliev (1,218 words) [view diff] exact match in snippet view article find links to article
already existing cycles of individual development. Taliev explained directed evolution by the physical and chemical reasons and suggested that in the courseCell sorting (4,501 words) [view diff] exact match in snippet view article find links to article
"Ultrahigh-throughput screening in drop-based microfluidics for directed evolution". Proceedings of the National Academy of Sciences of the United StatesPhilipp Holliger (1,171 words) [view diff] exact match in snippet view article find links to article
PMID 9032075. Ghadessy, F. J.; Ong, J. L.; Holliger, P. (2001-03-27). "Directed evolution of polymerase function by compartmentalized self-replication". ProceedingsProject Veritas (21,122 words) [view diff] exact match in snippet view article find links to article
the video, stating that it had not done any "gain of function or directed evolution research" during its development of its COVID-19 vaccine. MultipleKinetic exclusion assay (2,009 words) [view diff] exact match in snippet view article find links to article
R. Anthony; Burton, Dennis R.; Plückthun, Andreas (2006-10-13). "Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM andOff-target genome editing (7,122 words) [view diff] exact match in snippet view article find links to article
increasingly robust and reliable RNA-guided nuclease editing tools. Directed evolution can also be used to reduce nuclease activity on particular targetMicrosomal epoxide hydrolase (2,780 words) [view diff] exact match in snippet view article find links to article
J, Archelas A, Bottalla AL, Naworyta A, Mowbray SL (June 2009). "Directed evolution of an enantioselective epoxide hydrolase: uncovering the source ofList of Bengalis (17,155 words) [view diff] exact match in snippet view article find links to article
Research Center Ananda Mohan Chakrabarty, most notable for his work in directed evolution and his role in developing a genetically engineered organism usingBioTork (518 words) [view diff] exact match in snippet view article find links to article
Crecy, E; Jaronski, S; Lyons, B; Lyons, TJ; Keyhani, NO (2009). "Directed evolution of a filamentous fungus for thermotolerance". BMC Biotechnol. 9: 74RNA hydrolysis (740 words) [view diff] case mismatch in snippet view article find links to article
PMID 7935797. S2CID 4314759. Beaudry, Amber; Joyce, Gerald (1992). "Directed Evolution of an RNA Enzyme". Science. 257 (5070): 635–641. Bibcode:1992Sci.Andrimid (785 words) [view diff] exact match in snippet view article find links to article
PMID 18652473. Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR (July 2007). "Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes"List of biologists (20,787 words) [view diff] exact match in snippet view article find links to article
American biochemist and biochemical engineer, pioneer of the use of directed evolution to engineer enzymes. Ruth Arnon (born 1933), Israeli biochemist, whoSteven A. Benner (3,908 words) [view diff] exact match in snippet view article find links to article
Benner, Steven A. (31 October 2014). "DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides". Frontiers in MicrobiologyMorpheein (6,772 words) [view diff] exact match in snippet view article find links to article
"Simultaneous optimization of enzyme activity and quaternary structure by directed evolution". Protein Science. 14 (8): 2103–14. doi:10.1110/ps.051431605. PMC 2279322Jürgen Brosius (2,480 words) [view diff] exact match in snippet view article find links to article
Genomics. 2003;3(1-4):1-17 Brosius J. From Eden to a hell of uniformity? Directed evolution in humans.Bioessays. 2003 Aug;25(8):815-21 Patent U.S. # 5,670,318Phloroglucinol synthase (207 words) [view diff] exact match in snippet view article find links to article
2025. Retrieved 26 April 2025. Rao G, Lee JK, Zhao H (July 2013). "Directed evolution of phloroglucinol synthase PhlD with increased stability for phloroglucinol2018 in science (22,305 words) [view diff] exact match in snippet view article find links to article
laser physics" Nobel Prize in Chemistry – Frances H. Arnold, "for the directed evolution of enzymes", George P. Smith and Gregory P. Winter, "for the phageOptogenetic methods to record cellular activity (2,470 words) [view diff] case mismatch in snippet view article find links to article
Altermatt, Michael; Liang, Ruqiang; Matsui, Aya; et al. (December 2020). "Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning"Sabine Flitsch (1,313 words) [view diff] exact match in snippet view article find links to article
Flitsch’s research group has engineered tailored biocatalysts via directed evolution, and to address the biological challenge of 'sequencing' carbohydratesFMN-binding fluorescent protein (1,563 words) [view diff] exact match in snippet view article find links to article
PMID 19060199. Mukherjee A, Weyant KB, Walker J, Schroeder CM (2012). "Directed evolution of bright mutants of an oxygen-independent flavin-binding fluorescentGene regulatory circuit (1,319 words) [view diff] exact match in snippet view article find links to article
S2CID 49222385. Yokobayashi, Y.; Weiss, R.; Arnold, F. H. (2002-12-24). "Directed evolution of a genetic circuit". Proceedings of the National Academy of SciencesList of biochemists (11,274 words) [view diff] exact match in snippet view article find links to article
biochemist and biochemical engineer at Caltech, pioneer of the use of directed evolution to engineer enzymes. Nobel Prize for Chemistry (2018). Member NatlJason Micklefield (1,701 words) [view diff] exact match in snippet view article find links to article
in biocatalysis. His lab employed structure-guided mutagenesis and directed evolution to improve activity, expand the substrate scope and switch the regioselectivitiesProcess chemistry (4,405 words) [view diff] exact match in snippet view article find links to article
transaminase enzyme from the bacteria Arthrobacter through 11 rounds of directed evolution. The engineered transaminase contained 27 individual point mutationsNiranjan Parajuli (2,046 words) [view diff] exact match in snippet view article find links to article
Parajuli, N., and Williams, G.J. (2011). A high-throughput screen for directed evolution of aminocoumarin amide synthetases. Analytical Biochemistry 419, 61–66Fluorescent glucose biosensor (7,448 words) [view diff] exact match in snippet view article find links to article
a single dye (Ianbd) attached to E149C as a starting point for a directed evolution screen, in which a mutant library is created and selected for "winners"Imine reductase (760 words) [view diff] exact match in snippet view article find links to article
(2019-09-16). "Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase". Nature Catalysis. 2 (10): 909–915. doi:10ImmTAC (657 words) [view diff] exact match in snippet view article find links to article
Baston E, Dunn S, Liddy N, Jacob J, Jakobsen BK, Boulter JM (2005). "Directed evolution of human T-cell receptors with picomolar affinities by phage display"Murine respirovirus (32,094 words) [view diff] exact match in snippet view article find links to article
Kochneva GV, Netesov SV, Chumakov PM, Matveeva OV (July 2019). "Directed evolution as a tool for the selection of oncolytic RNA viruses with desiredCsaba Pal (1,959 words) [view diff] exact match in snippet view article find links to article
2013.57. PMC 3817406. PMID 24169403. Bokor, Dóra (11 June 2018). "Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance"A. C. Matin (3,681 words) [view diff] exact match in snippet view article find links to article
enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution". Molecular Cancer Therapeutics. 5 (1): 97–103. doi:10.1158/1535-7163List of California Institute of Technology people (14,530 words) [view diff] exact match in snippet view article find links to article
Innovation recipient; Nobel laureate in chemistry (2018) "for the directed evolution of enzymes" Jay Bailey, former faculty John D. Baldeschwieler, NationalList of National Inventors Hall of Fame inductees (15,291 words) [view diff] case mismatch in snippet view article find links to article
Retrieved January 5, 2020. "NIHF Inductee Frances Arnold Pioneered Directed Evolution". www.invent.org. April 6, 2024. Archived from the original on JuneRecursive self-improvement (1,228 words) [view diff] exact match in snippet view article find links to article
might develop for itself. This forms the basis for a kind of self-directed evolution, where the agent can perform a kind of artificial selection, changingReward hacking (1,510 words) [view diff] exact match in snippet view article find links to article
'agenda' distinct from the programmer's" and that "the first rule of directed evolution is 'you get what you select for'". In 2013, programmer Tom MurphySelective organ targeting (2,174 words) [view diff] case mismatch in snippet view article find links to article
"Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution". Journal of the American Chemical Society. 140 (49): 17095–17105Shimshon Belkin (2,483 words) [view diff] exact match in snippet view article find links to article
6-trinitrotoluene by an Escherichia coli bioreporter: performance enhancement by directed evolution". Applied Microbiology and Biotechnology. 99 (17): 7177–7188. doi:10List of American Nobel laureates (187 words) [view diff] exact match in snippet view article find links to article
sensor" 2018 Frances Arnold Edgewood, Pennsylvania, U.S. "for the directed evolution of enzymes" 2017 Joachim Frank Siegen, Germany "for the discoveryBias in the introduction of variation (14,511 words) [view diff] exact match in snippet view article find links to article
"Making the case for orthogenesis: The popularization of definitely directed evolution (1890–1926)". Studies in History and Philosophy of Science Part C: