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Longer titles found: Directed evolution (transhumanism) (view)

searching for Directed evolution 123 found (236 total)

Teleology in biology (4,036 words) [view diff] case mismatch in snippet view article find links to article

ISSN 0305-0270. Askland, Andrew (2011). "The Misnomer of Transhumanism as Directed Evolution" (PDF). International Journal of Emerging Technologies and Society

Bryan Roth (726 words) [view diff] exact match in snippet view article find links to article

identification of new probes and tools to detect GPCRs, obtained through directed evolution in animal cells, developing receptors activated solely by a synthetic

Ribosome display (966 words) [view diff] exact match in snippet view article find links to article

be transformed after any diversification step. This allows facile directed evolution of binding proteins over several generations. A prerequisite for the

Theodor Eimer (817 words) [view diff] exact match in snippet view article find links to article

German zoologist. He was a popularizer of orthogenesis, a form of directed evolution through mutations that made use of Lamarckian principles. Eimer was

Threose nucleic acid (1,216 words) [view diff] exact match in snippet view article find links to article

incoming TNA nucleotide triphosphate and support the need for further directed evolution experiments to create TNA polymerases with improved activity. The

Monobody (1,510 words) [view diff] exact match in snippet view article find links to article

portions of the FN3 scaffold are diversified using molecular display and directed evolution technologies such as phage display, mRNA display and yeast surface

Huimin Zhao (271 words) [view diff] exact match in snippet view article find links to article

Carl R. Woese Institute for Genomic Biology. His research focuses on directed evolution, metabolic engineering, bioinformatics and high throughput technologies

Oncolytic adenovirus (4,201 words) [view diff] exact match in snippet view article find links to article

currently in development is ColoAd1. It was created using a process of “directed evolution”. This involves the creation of new viral variants or serotypes specifically

Nicholas Turner (chemist) (1,057 words) [view diff] exact match in snippet view article

His group combine enzyme discovery with protein engineering and directed evolution methods in order to develop biocatalysts with tailored properties

SNAP-tag (1,001 words) [view diff] exact match in snippet view article find links to article

O-6-methylguanine-DNA methyltransferase (MGMT) gene. SNAP-tag was obtained using a directed evolution strategy, leading to a hAGT variant that accepts O6-benzylguanine

Molecular genetics (3,815 words) [view diff] case mismatch in snippet view article find links to article

Retrieved 2023-10-16. "Selection versus Screening in Directed Evolution", Directed Evolution of Selective Enzymes, John Wiley & Sons, Ltd, 2016, pp

George I. Mavrodes (516 words) [view diff] exact match in snippet view article find links to article

understanding of evolution holds that although evolution occurred, God still directed evolution. Evolution is merely the tool of God's design. Evolution, and even

Site-directed mutagenesis (2,980 words) [view diff] exact match in snippet view article find links to article

Steinberg, Barrett E. (16 April 2020). "SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4):

In vitro compartmentalization (2,195 words) [view diff] exact match in snippet view article find links to article

007. PMID 17055094. Ghadessy FJ, Ong JL, Holliger P (April 2001). "Directed evolution of polymerase function by compartmentalized self-replication". Proceedings

Multicellular organism (4,856 words) [view diff] exact match in snippet view article find links to article

identified by directed evolution. More recently (2024), snowflake yeast were subject to over 3,000 generations of further directed evolution, forming macroscopic

Ulrich Schwaneberg (839 words) [view diff] exact match in snippet view article find links to article

Institute for Interactive Materials in Aachen. He specializes in directed evolution of proteins for material science applications and on the development

Cambridge Antibody Technology (8,541 words) [view diff] exact match in snippet view article find links to article

L; Minter, RR (2006). "Probing a protein-protein interaction by directed evolution". Proc Natl Acad Sci USA. 103 (20): 7619–24. Bibcode:2006PNAS..103

Theistic evolution (7,503 words) [view diff] exact match in snippet view article find links to article

different positions from the 1890s to the 1920s: "Orthogenesis" (goal-directed evolution), "nomogenesis" (evolution according to fixed law), "emergent evolution"

Invertebrate (4,979 words) [view diff] exact match in snippet view article find links to article

and vertebrates were closer than invertebrates were. Although goal-directed evolution has been abandoned, the distinction of invertebrates and vertebrates

Edward F. Fritsch (709 words) [view diff] no match in snippet view article find links to article

(EPO) gene. Fritsch then joined Phylos, Inc. to utilize a in vitro, directed-evolution technology to discover new protein therapeutics, eventually becoming

Beta-2 microglobulin (2,118 words) [view diff] case mismatch in snippet view article find links to article

HLA-G 2esv: Structure of the HLA-E-VMAPRTLIL/KK50.4 TCR complex 2f53: Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically

Gaia hypothesis (9,256 words) [view diff] case mismatch in snippet view article find links to article

hypothesis has been called "influential Gaia" in the 2002 paper "Directed Evolution of the Biosphere: Biogeochemical Selection or Gaia?" by Andrei G.

Michael Denton (742 words) [view diff] exact match in snippet view article find links to article

of organisms; he has proposed an evolutionary theory which is a "directed evolution" in his book Nature's Destiny (1998). Life, according to Denton, did

Β-Galactosidase (3,025 words) [view diff] exact match in snippet view article find links to article

1981). "Changes in the substrate specificities of an enzyme during directed evolution of new functions". Biochemistry. 20 (14): 4042–9. doi:10.1021/bi00517a015

Aeropyrum pernix (637 words) [view diff] exact match in snippet view article find links to article

of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering Design & Selection. 17 (11): 771–777. doi:10

Fluorescence-activating and absorption-shifting tag (1,829 words) [view diff] exact match in snippet view article find links to article

protein, was engineered from the photoactive yellow protein (PYP) by directed evolution. It was disclosed for the first time in 2016 by researchers from Ecole

Broad Institute (2,662 words) [view diff] exact match in snippet view article find links to article

Institute, the inventor of DNA-templated synthesis, phage-assisted directed evolution and Cas9/CRISPR base-editing. Stuart Schreiber is director of the

2-Dehydro-3-deoxy-phosphogluconate aldolase (1,633 words) [view diff] case mismatch in snippet view article find links to article

amino acid sequences yet analogous symmetrical structure and folding. Directed Evolution KDPG aldolase has limited utility due to its high specificity for

Baeyer–Villiger oxidation (2,981 words) [view diff] case mismatch in snippet view article find links to article

Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution". Journal of the American Chemical Society. 140 (33): 10464–10472

Inositol oxygenase (1,818 words) [view diff] exact match in snippet view article find links to article

numerous strategies including appendage of an N-terminal SUMO-tag, directed evolution and also the use of modular, synthetic scaffolds to increase its effective

Enzyme (9,890 words) [view diff] exact match in snippet view article find links to article

Eggert T (August 2004). "Enantioselective biocatalysis optimized by directed evolution". Current Opinion in Biotechnology. 15 (4): 305–313. doi:10.1016/j

Cope's rule (1,976 words) [view diff] exact match in snippet view article find links to article

this is usually a result of size varying pseudo-randomly rather than directed evolution. This does not fall into Cope's rule sensu stricto, but is considered

HLA-A (3,411 words) [view diff] case mismatch in snippet view article find links to article

PEPTIDE EXTENDING OUT ONE END OF A CLASS I MHC BINDING SITE 2f53: Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically

DNA methyltransferase (3,598 words) [view diff] exact match in snippet view article find links to article

recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution". Journal of Molecular Biology. 395 (1): 79–88. doi:10.1016/j.jmb

Acetoacetyl-CoA (879 words) [view diff] exact match in snippet view article find links to article

Watanabe T, Motohashi R, Ikeda K, Tobitani K, et al. (October 2013). "Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A

Structuralism (biology) (2,365 words) [view diff] exact match in snippet view article

developmental constraints, led (solid blue arrows) to some form of directed evolution (orthogenesis), with or without invoking divine control (dotted blue

MRC Laboratory of Molecular Biology (3,821 words) [view diff] exact match in snippet view article find links to article

PMID 23741620. World2018-10-03T11:06:00+01:00, Chemistry. "Live blog: directed evolution takes chemistry Nobel prize". Chemistry World. Retrieved 23 February

Jane Glazebrook (748 words) [view diff] case mismatch in snippet view article find links to article

Casim. (February 2017-February 2019). Engineering Plant Immunity via Directed Evolution of Imm. USDA National Institute of Food & Agriculture. Glazebook,

Carl Nägeli (1,031 words) [view diff] exact match in snippet view article find links to article

Darwinism. He developed an "inner perfecting principle" which he believed directed evolution. He wrote that many evolutionary developments were nonadaptive and

Edward Boyden (3,439 words) [view diff] exact match in snippet view article find links to article

Shemesh, Or; Asano, Shoh (April 2018). "A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters". Nature Chemical

Islamic views on evolution (4,475 words) [view diff] no match in snippet view article find links to article

acceptance, albeit divinely designed. The movement actively promotes god-directed "evolution". Over the course of several decades the movement issued various

Christian fundamentalism (7,947 words) [view diff] exact match in snippet view article find links to article

the Bible, and others were comfortable teaching some forms of God-directed evolution. Riley and the more strident fundamentalists, however, associated

Virus (18,258 words) [view diff] exact match in snippet view article find links to article

A particular quality of viruses is that they can be tailored by directed evolution. The powerful techniques developed by life sciences are becoming the

Karl Ernst von Baer (2,897 words) [view diff] exact match in snippet view article find links to article

organisms. Baer believed in a teleological force in nature which directed evolution (orthogenesis). The term Baer's law is also applied to the unconfirmed

Hemoprotein (2,454 words) [view diff] exact match in snippet view article find links to article

Schneider P, Vind J, Svendsen A, Jones A, Pedersen AH (April 1999). "Directed evolution of a fungal peroxidase". Nature Biotechnology. 17 (4): 379–384. doi:10

High-throughput screening (4,314 words) [view diff] exact match in snippet view article find links to article

Mazaleyrat, S. L. (2007). "Development of a screening platform for directed evolution using the reef coral fluorescent protein ZsGreen as a solubility reporter"

Pyrococcus woesei (317 words) [view diff] exact match in snippet view article find links to article

Ai-Sheng; Peng, Ri-He; Zhuang, Jing; Li, Xian; et al. (18 Sep 2007). "Directed evolution of a beta-galactosidase from Pyrococcus woesei resulting in increased

SeSaM-Biotech GmbH (882 words) [view diff] exact match in snippet view article find links to article

Retrieved April 24, 2017. Cheng, F.; Zhu, L.; Schwaneberg, U. (2015). "Directed evolution 2.0: improving and deciphering enzyme properties" (PDF). Chem. Commun

Carbonic anhydrase (4,361 words) [view diff] exact match in snippet view article find links to article

CK, Bresson JA, Lakhapatri SL, Solis EO, et al. (November 2014). "Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture

Adeno-associated virus (8,622 words) [view diff] exact match in snippet view article find links to article

another strain. For example: Mixing AAV2 and AAV5, then undergoing directed evolution, can produce a virus that targets the respiratory tract. AAV2/5, a

Transcription activator-like effector nuclease (3,148 words) [view diff] exact match in snippet view article find links to article

PMID 17603476. S2CID 22079561. Guo J, Gaj T, Barbas CF (July 2010). "Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc

Neutral network (evolution) (2,832 words) [view diff] exact match in snippet view article

L; Kast, P; van Gunsteren, WF; Marlière, P; Hilvert, D (2013). "Directed evolution of a model primordial enzyme provides insights into the development

Green fluorescent protein (7,449 words) [view diff] case mismatch in snippet view article find links to article

PMC 5007177. PMID 27479328. Mattson S, Tran GN, Rodriguez EA (2023). "Directed Evolution of Fluorescent Proteins in Bacteria". In Sharma M (ed.). Fluorescent

Yersinia mollaretii (177 words) [view diff] exact match in snippet view article find links to article

Roccatano, Danilo; Haefner, Stefan; Schwaneberg, Ulrich (2011). "Directed evolution of a highly active Yersinia mollaretii phytase". Applied Microbiology

On the Origin of Species (18,861 words) [view diff] exact match in snippet view article find links to article

tried to meet these objections in the fifth edition. Mivart supported directed evolution, and compiled scientific and religious objections to natural selection

Phytoene desaturase (neurosporene-forming) (217 words) [view diff] exact match in snippet view article

product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution". The Journal of Biological Chemistry. 276 (44): 41161–4. doi:10.1074/jbc

Irish elk (6,842 words) [view diff] exact match in snippet view article find links to article

with smaller antlers, was taken as a prime example of orthogenesis (directed evolution), an evolutionary mechanism opposed to Darwinian evolution in which

Geranylfarnesyl diphosphate synthase (249 words) [view diff] exact match in snippet view article find links to article

of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering, Design & Selection. 17 (11): 771–7. doi:10

Alfred Russel Wallace (14,346 words) [view diff] exact match in snippet view article find links to article

commented that this anticipated ideas about design in nature and directed evolution that would arise from religious traditions throughout the 20th century

Halohydrin dehalogenase (969 words) [view diff] exact match in snippet view article find links to article

dehalogenase from Arthrobacter sp. strain AD2, revealed by structure-guided directed evolution". Appl Environ Microbiol. 78 (8): 4051–4056. Bibcode:2012ApEnM..78

Xeno nucleic acid (2,623 words) [view diff] case mismatch in snippet view article find links to article

Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution". Biomolecules. 10 (12): 1647. doi:10.3390/biom10121647. ISSN 2218-273X

PON3 (901 words) [view diff] exact match in snippet view article find links to article

1038/nature01782. PMID 12853948. Aharoni A, Gaidukov L, Yagur S, et al. (2004). "Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and

Pseudonocardia autotrophica (307 words) [view diff] exact match in snippet view article find links to article

Tamura, Tomohiro (July 2009). "Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica"

Diapolycopene oxygenase (153 words) [view diff] exact match in snippet view article find links to article

synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution". Chemistry & Biology. 12 (4): 453–60. doi:10.1016/j.chembiol.2005

Mosaic protein (621 words) [view diff] exact match in snippet view article find links to article

S2CID 24447528. Kolkman, Joost A.; Stemmer, Willem P. C. (2001-05-01). "Directed evolution of proteins by exon shuffling". Nature Biotechnology. 19 (5): 423–428

Bicyclobutane (726 words) [view diff] exact match in snippet view article find links to article

Anabaena sphaerica (strain PCC 7120). The other group reported a directed evolution approach, whereby engineered heme protein was expressed in E. coli

Alternatives to Darwinian evolution (5,856 words) [view diff] exact match in snippet view article find links to article

arrows). Many of these theories led (blue arrows) to some form of directed evolution (orthogenesis), with or without invoking divine control (dotted blue

Microbial genetics (5,154 words) [view diff] exact match in snippet view article find links to article

method of production is the ability to direct optimization by means of directed evolution. The efficiency and specificity of production will increase over time

Robustness (evolution) (4,629 words) [view diff] exact match in snippet view article

Gaillon L, Kast P, van Gunsteren WF, Marlière P, Hilvert D (2013). "Directed evolution of a model primordial enzyme provides insights into the development

Ascorbate peroxidase (1,255 words) [view diff] exact match in snippet view article find links to article

KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY (January 2015). "Directed evolution of APEX2 for electron microscopy and proximity labeling". Nature Methods

Circular permutation in proteins (3,511 words) [view diff] exact match in snippet view article find links to article

96.20.11241. PMC 18018. PMID 10500161. Turner NJ (August 2009). "Directed evolution drives the next generation of biocatalysts". Nature Chemical Biology

Alkalihalobacillus alcalophilus (367 words) [view diff] exact match in snippet view article find links to article

of cold adaptation of Bacillus alcalophilus alkaline protease by directed evolution". Journal of Molecular Catalysis B: Enzymatic. 106: 117–123. doi:10

Microbiome (11,896 words) [view diff] exact match in snippet view article find links to article

PMC 4575871. PMID 26109480. Bloom JD, Arnold FH (2009). "In the light of directed evolution: Pathways of adaptive protein evolution". Proceedings of the National

Cas9 (5,688 words) [view diff] exact match in snippet view article find links to article

JK, Jeong E, Lee J, Jung M, Shin E, Kim YH, et al. (August 2018). "Directed evolution of CRISPR-Cas9 to increase its specificity". Nature Communications

Deoxyribozyme (4,676 words) [view diff] exact match in snippet view article find links to article

1073/pnas.0305943101. PMC 314139. PMID 14691255. Joyce GF (2004). "Directed evolution of nucleic acid enzymes". Annual Review of Biochemistry. 73 (1): 791–836

Zero-shot learning (1,392 words) [view diff] case mismatch in snippet view article find links to article

Yisong; Arnold, Frances H. (2020-12-04). "Machine Learning-Assisted Directed Evolution Navigates a Combinatorial Epistatic Fitness Landscape with Minimal

List of biophysicists (2,490 words) [view diff] exact match in snippet view article find links to article

reactions of photosynthesis, genetic code, imaging spectroscopy and directed evolution Bruno Zimm — co-developer of the Zimm-Bragg model of helix formation

Ferdinand Bohlmann (398 words) [view diff] case mismatch in snippet view article find links to article

California Institute of Technology United States Manfred T. Reetz 2004 Directed Evolution of Enantioselective Enzymes Max-Planck-Institut für Kohlenforschung

HKA test (833 words) [view diff] case mismatch in snippet view article find links to article

Example of Directed Evolution - Selection

Exon shuffling (2,249 words) [view diff] exact match in snippet view article find links to article

PMID 14634634. S2CID 33999892. Kolkman JA, Stemmer WP (May 2001). "Directed evolution of proteins by exon shuffling". Nature Biotechnology. 19 (5): 423–428

Evidence of common descent (27,684 words) [view diff] exact match in snippet view article find links to article

such as proteins." Evolutionary molecular engineering, also called directed evolution or in vitro molecular evolution involves the iterated cycle of mutation

Enadenotucirev (372 words) [view diff] case mismatch in snippet view article find links to article

ongoing clinical study. Oncolytic adenovirus Oncolytic adenovirus#Directed Evolution "Enadenotucirev". PsiOxus Therapeutics. Retrieved 2019-07-04. Machiels

Wolfgang Schad (724 words) [view diff] case mismatch in snippet view article find links to article

Vegetation in the Bergisch-Märkische Hügelland Wirz, Johannes (2014). "Directed Evolution: Commentary on Wolfgang Schad's Archäopteryx lithographica – eine

Valery Taliev (1,218 words) [view diff] exact match in snippet view article find links to article

already existing cycles of individual development. Taliev explained directed evolution by the physical and chemical reasons and suggested that in the course

Cell sorting (4,501 words) [view diff] exact match in snippet view article find links to article

"Ultrahigh-throughput screening in drop-based microfluidics for directed evolution". Proceedings of the National Academy of Sciences of the United States

Philipp Holliger (1,171 words) [view diff] exact match in snippet view article find links to article

PMID 9032075. Ghadessy, F. J.; Ong, J. L.; Holliger, P. (2001-03-27). "Directed evolution of polymerase function by compartmentalized self-replication". Proceedings

Kinetic exclusion assay (2,009 words) [view diff] exact match in snippet view article find links to article

R. Anthony; Burton, Dennis R.; Plückthun, Andreas (2006-10-13). "Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and

Microsomal epoxide hydrolase (2,780 words) [view diff] exact match in snippet view article find links to article

J, Archelas A, Bottalla AL, Naworyta A, Mowbray SL (June 2009). "Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of

Project Veritas (21,147 words) [view diff] exact match in snippet view article find links to article

the video, stating that it had not done any "gain of function or directed evolution research" during its development of its COVID-19 vaccine. Multiple

Off-target genome editing (6,846 words) [view diff] exact match in snippet view article find links to article

increasingly robust and reliable RNA-guided nuclease editing tools. Directed evolution can also be used to reduce nuclease activity on particular target

List of Bengalis (16,449 words) [view diff] exact match in snippet view article find links to article

Research Center Ananda Mohan Chakrabarty, most notable for his work in directed evolution and his role in developing a genetically engineered organism using

2018 in science (22,304 words) [view diff] exact match in snippet view article find links to article

laser physics" Nobel Prize in Chemistry – Frances H. Arnold, "for the directed evolution of enzymes", George P. Smith and Gregory P. Winter, "for the phage

BioTork (518 words) [view diff] exact match in snippet view article find links to article

Crecy, E; Jaronski, S; Lyons, B; Lyons, TJ; Keyhani, NO (2009). "Directed evolution of a filamentous fungus for thermotolerance". BMC Biotechnol. 9: 74

Andrimid (785 words) [view diff] exact match in snippet view article find links to article

PMID 18652473. Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR (July 2007). "Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes"

BioTork (518 words) [view diff] exact match in snippet view article find links to article

Crecy, E; Jaronski, S; Lyons, B; Lyons, TJ; Keyhani, NO (2009). "Directed evolution of a filamentous fungus for thermotolerance". BMC Biotechnol. 9: 74

RNA hydrolysis (740 words) [view diff] case mismatch in snippet view article find links to article

PMID 7935797. S2CID 4314759. Beaudry, Amber; Joyce, Gerald (1992). "Directed Evolution of an RNA Enzyme". Science. 257 (5070): 635–641. Bibcode:1992Sci.

List of biologists (20,780 words) [view diff] exact match in snippet view article find links to article

American biochemist and biochemical engineer, pioneer of the use of directed evolution to engineer enzymes. Ruth Arnon (born 1933), Israeli biochemist, who

Steven A. Benner (3,898 words) [view diff] exact match in snippet view article find links to article

Benner, Steven A. (31 October 2014). "DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides". Frontiers in Microbiology

Morpheein (6,770 words) [view diff] exact match in snippet view article find links to article

"Simultaneous optimization of enzyme activity and quaternary structure by directed evolution". Protein Science. 14 (8): 2103–14. doi:10.1110/ps.051431605. PMC 2279322

Jürgen Brosius (2,480 words) [view diff] exact match in snippet view article find links to article

Genomics. 2003;3(1-4):1-17 Brosius J. From Eden to a hell of uniformity? Directed evolution in humans.Bioessays. 2003 Aug;25(8):815-21 Patent U.S. # 5,670,318

FMN-binding fluorescent protein (1,563 words) [view diff] exact match in snippet view article find links to article

PMID 19060199. Mukherjee A, Weyant KB, Walker J, Schroeder CM (2012). "Directed evolution of bright mutants of an oxygen-independent flavin-binding fluorescent

Optogenetic methods to record cellular activity (2,470 words) [view diff] case mismatch in snippet view article find links to article

Altermatt, Michael; Liang, Ruqiang; Matsui, Aya; et al. (December 2020). "Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning"

Sabine Flitsch (1,243 words) [view diff] exact match in snippet view article find links to article

Flitsch’s research group has engineered tailored biocatalysts via directed evolution, and to address the biological challenge of 'sequencing' carbohydrates

List of biochemists (11,204 words) [view diff] exact match in snippet view article find links to article

biochemist and biochemical engineer at Caltech, pioneer of the use of directed evolution to engineer enzymes. Nobel Prize for Chemistry (2018). Member Natl

Jason Micklefield (1,701 words) [view diff] exact match in snippet view article find links to article

in biocatalysis. His lab employed structure-guided mutagenesis and directed evolution to improve activity, expand the substrate scope and switch the regioselectivities

Gene regulatory circuit (1,319 words) [view diff] exact match in snippet view article find links to article

S2CID 49222385. Yokobayashi, Y.; Weiss, R.; Arnold, F. H. (2002-12-24). "Directed evolution of a genetic circuit". Proceedings of the National Academy of Sciences

Niranjan Parajuli (1,893 words) [view diff] exact match in snippet view article find links to article

Parajuli, N., and Williams, G.J. (2011). A high-throughput screen for directed evolution of aminocoumarin amide synthetases. Analytical Biochemistry 419, 61–66

Process chemistry (4,405 words) [view diff] exact match in snippet view article find links to article

transaminase enzyme from the bacteria Arthrobacter through 11 rounds of directed evolution. The engineered transaminase contained 27 individual point mutations

Fluorescent glucose biosensor (7,448 words) [view diff] exact match in snippet view article find links to article

a single dye (Ianbd) attached to E149C as a starting point for a directed evolution screen, in which a mutant library is created and selected for "winners"

Imine reductase (760 words) [view diff] exact match in snippet view article find links to article

(2019-09-16). "Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase". Nature Catalysis. 2 (10): 909–915. doi:10

ImmTAC (657 words) [view diff] exact match in snippet view article find links to article

Baston E, Dunn S, Liddy N, Jacob J, Jakobsen BK, Boulter JM (2005). "Directed evolution of human T-cell receptors with picomolar affinities by phage display"

Murine respirovirus (32,091 words) [view diff] exact match in snippet view article find links to article

Kochneva GV, Netesov SV, Chumakov PM, Matveeva OV (July 2019). "Directed evolution as a tool for the selection of oncolytic RNA viruses with desired

Csaba Pal (1,959 words) [view diff] exact match in snippet view article find links to article

2013.57. PMC 3817406. PMID 24169403. Bokor, Dóra (11 June 2018). "Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance"

A. C. Matin (3,681 words) [view diff] exact match in snippet view article find links to article

enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution". Molecular Cancer Therapeutics. 5 (1): 97–103. doi:10.1158/1535-7163

History of eugenics (18,086 words) [view diff] case mismatch in snippet view article find links to article

edu. 6 June 2018. Retrieved 2018-10-01. Maxwell J. Mehlman, Will Directed Evolution Destroy Humanity, and If So, What Can We Do About It?, 3 St. Louis

List of California Institute of Technology people (14,329 words) [view diff] exact match in snippet view article find links to article

Innovation recipient; Nobel laureate in chemistry (2018) "for the directed evolution of enzymes" Jay Bailey, former faculty John D. Baldeschwieler, National

List of National Inventors Hall of Fame inductees (14,627 words) [view diff] case mismatch in snippet view article find links to article

Retrieved January 5, 2020. "NIHF Inductee Frances Arnold Pioneered Directed Evolution". www.invent.org. April 6, 2024. Archived from the original on June

Recursive self-improvement (1,245 words) [view diff] exact match in snippet view article find links to article

might develop for itself. This forms the basis for a kind of self-directed evolution, where the agent can perform a kind of artificial selection, changing

Reward hacking (1,510 words) [view diff] exact match in snippet view article find links to article

'agenda' distinct from the programmer's" and that "the first rule of directed evolution is 'you get what you select for'". In 2013, programmer Tom Murphy

Selective organ targeting (2,174 words) [view diff] case mismatch in snippet view article find links to article

"Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution". Journal of the American Chemical Society. 140 (49): 17095–17105

Shimshon Belkin (2,487 words) [view diff] exact match in snippet view article find links to article

6-trinitrotoluene by an Escherichia coli bioreporter: performance enhancement by directed evolution". Applied Microbiology and Biotechnology. 99 (17): 7177–7188. doi:10

List of American Nobel laureates (187 words) [view diff] exact match in snippet view article find links to article

sensor" 2018 Frances Arnold Edgewood, Pennsylvania, U.S. "for the directed evolution of enzymes" 2017 Joachim Frank Siegen, Germany "for the discovery

Bias in the introduction of variation (14,511 words) [view diff] exact match in snippet view article find links to article

"Making the case for orthogenesis: The popularization of definitely directed evolution (1890–1926)". Studies in History and Philosophy of Science Part C: