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searching for Co-stimulation 43 found (73 total)

Somatostatin receptor (155 words) [view diff] exact match in snippet view article find links to article

signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible

Abatacept (853 words) [view diff] exact match in snippet view article find links to article

fully activated, and even downregulates them. Simple signaling without co-stimulation allows the cell to recognize the primary signal as "self" and not ramp-up

CD58 (2,682 words) [view diff] exact match in snippet view article find links to article

cell co-stimulation via LFA-1/ICAM-1 and CD2/LFA-3: demonstration with immobilized ligand/mAb and implication in monocyte-mediated co-stimulation". European

CD37 (1,539 words) [view diff] exact match in snippet view article find links to article

"Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1): 50–5. doi:10.1002/eji

Melanocyte (2,278 words) [view diff] exact match in snippet view article find links to article

proteins such as CD40 and ICAM1 in addition to MHC class II, allowing for co-stimulation of T cells. In addition to presenting antigen, one of the roles of melanocytes

Fusion protein (2,305 words) [view diff] exact match in snippet view article find links to article

immune thrombocytopenia. Abatacept/Belatacept: Interferes with T-cell co-stimulation to treat autoimmune disorders like rheumatoid arthritis, psoriatic arthritis

GPR183 (1,430 words) [view diff] exact match in snippet view article find links to article

maximizes interactions with T cells. Following B cell receptor and CD40 co-stimulation, EBI2 is again upregulated. The B cells thus move back toward the outer

CD278 (1,933 words) [view diff] exact match in snippet view article find links to article

Shahinian A, Shaklee CL, Van G, Mak TW, Senaldi G (Dec 1999). "T-cell co-stimulation through B7RP-1 and ICOS". Nature. 402 (6763): 827–32. Bibcode:1999Natur

CD244 (1,912 words) [view diff] exact match in snippet view article find links to article

Kambayashi T, Persson CM, Ljunggren HG, Chambers BJ (February 2005). "2B4 co-stimulation: NK cells and their control of adaptive immune responses". Molecular

ELISpot (1,980 words) [view diff] exact match in snippet view article find links to article

or decrease). To counteract capture effects, it is possible to use co-stimulation in order to bypass the decreased production of an analyte. This is when

ICOSLG (2,188 words) [view diff] exact match in snippet view article find links to article

Khare SD, Sarmiento U, Guo J, Horan T, et al. (December 1999). "T-cell co-stimulation through B7RP-1 and ICOS". Nature. 402 (6763): 827–832. Bibcode:1999Natur

CXCR5 (1,849 words) [view diff] exact match in snippet view article find links to article

Huang B, Zhang Q, Li Q, et al. (August 2004). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis

Cereblon E3 ligase modulator (5,487 words) [view diff] exact match in snippet view article find links to article

the co-stimulation of T-cells through the B7-CD28 complex by phosphorylating tyrosine on the CD28 receptor. In vitro data suggests this co-stimulation leads

NFAT (2,877 words) [view diff] exact match in snippet view article find links to article

stimulated without appropriate costimulatory signals. Because of the missing co-stimulation AP-1 is absent and a NFAT:NFAT complex is formed. This complex activates

CD137 (2,321 words) [view diff] exact match in snippet view article find links to article

Kim SH, Mantel P, Kwon BS (March 1998). "Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses". European Journal of Immunology. 28 (3):

Sterol regulatory element-binding protein 1 (2,147 words) [view diff] exact match in snippet view article find links to article

Bennett MK, Ngo TT, Athanikar JN, Rosenfeld JM, Osborne TF (May 1999). "Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory

PRKCQ (2,407 words) [view diff] exact match in snippet view article find links to article

synapse, whereas in effector T cells, PKC-θ is present. As a result of co-stimulation by CD28 and TCR, PKC-θ is sumoylated by SUMO1 predominantly on the sites

Ocular immune system (1,800 words) [view diff] exact match in snippet view article find links to article

found to combine synergistically with other interleukins to increase co-stimulation of other immune aspects as well as increase antibody secretion. The

CD40 (protein) (2,905 words) [view diff] exact match in snippet view article

histocompatibility complex (MHC) molecules, proinflammatory factor production, co-stimulation of CD4+ and CD8+ T cells, and tumor cell susceptibility to T-cell lysis

Tetrahymena (3,804 words) [view diff] exact match in snippet view article find links to article

encounter a cell of complementary mating type. After a brief period of co-stimulation (~1hr), starved cells begin to pair at their anterior ends to form a

Interleukin (4,194 words) [view diff] exact match in snippet view article find links to article

monocytes, dendritic cells CD121a/IL1R1, CD121b/IL1R2 T helper cells co-stimulation B cells maturation and proliferation NK cells activation macrophages

TRG (gene) (2,439 words) [view diff] exact match in snippet view article

these cells may upregulate several antigen-presentation, adhesion, and co-stimulation molecules that mimic dendritic cells, a particular type of APC. These

Rheumatic fever (5,870 words) [view diff] exact match in snippet view article find links to article

self reactive B cells remain anergic in the periphery without T cell co-stimulation. During a streptococcal infection, mature antigen-presenting cells such

Autoimmune disease (6,862 words) [view diff] exact match in snippet view article find links to article

Lee JC, Jayne DR, Lyons PA, Smith KG (July 2015). "T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection". Nature. 523 (7562)

Ipilimumab (4,684 words) [view diff] exact match in snippet view article find links to article

Sullivan TJ, Allison JP (April 1996). "Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro

Programmed cell death protein 1 (4,995 words) [view diff] exact match in snippet view article find links to article

MacDonald D, Arce F, Bennett CL, Collins M, Escors D (October 2011). "PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+

Checkpoint inhibitor (2,164 words) [view diff] exact match in snippet view article find links to article

MacDonald D, Arce F, Bennett CL, Collins M, Escors D (October 2011). "PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+

Tumor necrosis factor (6,227 words) [view diff] exact match in snippet view article find links to article

by factors such as disruption of inflammatory pathways by pathogens, co-stimulation with other cytokines, and cross-talk between TNFR1 and TNFR2. Additionally

Interleukin 10 (4,619 words) [view diff] exact match in snippet view article find links to article

"IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway". European Journal of Immunology. 30 (6): 1683–1690. doi:10

KCNA3 (4,367 words) [view diff] exact match in snippet view article find links to article

disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1

Lupus (14,864 words) [view diff] exact match in snippet view article find links to article

and infiltrate target tissues, have defects in signaling, adhesion, co-stimulation, gene transcription, and alternative splicing. The cytokines B-lymphocyte

Cancer immunology (3,766 words) [view diff] exact match in snippet view article find links to article

escape cytotoxic T cells is to stop expressing molecules essential for co-stimulation of cytotoxic T cells, such as CD80 or CD86. Tumor cells express molecules

PEG10 (1,356 words) [view diff] exact match in snippet view article find links to article

Zhang K, Sun Z, Liu J, Jin Y, Tan J (Aug 2004). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis

Wnt signaling pathway (7,432 words) [view diff] exact match in snippet view article find links to article

the Fz receptor directly interfaces with a trimeric G-protein. This co-stimulation of Dsh and the G-protein can lead to the activation of either PLC or

Rheumatoid arthritis (16,682 words) [view diff] exact match in snippet view article find links to article

as rituximab, interleukin 6 blockers such as tocilizumab, and T cell co-stimulation blockers such as abatacept. They are often used in combination with

Signaling lymphocytic activation molecule (1,117 words) [view diff] exact match in snippet view article find links to article

Kis-Toth K, Thai TH, Terhorst C, Tsokos GC (May 2011). "SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells". Autoimmunity

CBLB (gene) (1,393 words) [view diff] exact match in snippet view article

MacDonald D, Arce F, Bennett CL, Collins M, Escors D (August 2011). "PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+

Lesional demyelinations of the central nervous system (4,846 words) [view diff] exact match in snippet view article find links to article

myelin-recognizing T cells belong to a terminally differentiated subset called co-stimulation-independent effector-memory T cells. Recently other type of immune cells

TAAR1 (11,281 words) [view diff] exact match in snippet view article find links to article

hetero-oligomers, the capacity of NorEpi to stimulate Gi/o signaling is reduced by co-stimulation with 3-T1AM. The present study therefore points to a complex spectrum

PRDM1 (2,688 words) [view diff] exact match in snippet view article find links to article

into a germinal center B cell after receiving proper activation and co-stimulation. BLIMP-1 acts as a master gene regulating the transcriptional network

Gary Nabel (2,504 words) [view diff] exact match in snippet view article find links to article

therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation. Nat Cancer 2019. doi:10.1038/s43018-019-0004-z. 9. Xu L, Pegu A, Rao

Mario Rosemblatt (1,396 words) [view diff] exact match in snippet view article find links to article

growth, differentiation and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204: 1765-74, 2007 M. Rosemblatt and M.R. Bono. “Functional

Immunometabolism (3,181 words) [view diff] exact match in snippet view article find links to article

of costimulatory molecules, like CD28, appears to be crucial, as the co-stimulation manifests in mitochondrial morphology, thus allowing for higher oxidative