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searching for tAAR1 19 found (130 total)

alternate case: TAAR1

Substituted cathinone (2,370 words) [view diff] exact match in snippet view article find links to article

do not act as agonists of the human trace amine-associated receptor 1 (TAAR1). This may potentiate their stimulating and addictive effects. The derivatives

Reuptake (1,897 words) [view diff] exact match in snippet view article find links to article

It has been shown that AMPH acts upon trace amine-associated receptor 1 (TAAR1) to induce efflux and reuptake inhibition in the serotonin, norepinephrine

Glutamate transporter (2,828 words) [view diff] exact match in snippet view article find links to article

PMID 24950453. TAAR1 overexpression significantly decreased EAAT-2 levels and glutamate clearance ... METH treatment activated TAAR1 leading to intracellular

Bupropion (12,534 words) [view diff] exact match in snippet view article find links to article

showed agonist activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic

Monoamine transporter (2,342 words) [view diff] exact match in snippet view article find links to article

neurotransmitters. Once inside, it binds to TAAR1 or enters synaptic vesicles through VMAT2. When amphetamine binds to TAAR1, it reduces post-synaptic receptor

Excitatory amino acid reuptake inhibitor (479 words) [view diff] exact match in snippet view article find links to article

G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC (May 2011). "TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic

4-HO-MET (598 words) [view diff] exact match in snippet view article find links to article

Binding sites Binding affinity Ki (μM) 5-HT1A 0.228 5-HT2A 0.057 5-HT2C 0.141 D1 >25 D2 4 D3 6.7 α1A 9.7 α2A 2.4 TAAR1 3.1 H1 0.82 SERT 0.2 DAT >26 NET 13

5-MeO-MiPT (1,080 words) [view diff] exact match in snippet view article find links to article

Binding Sites Binding Affinity Ki (μM) 5-HT1A 0.058 5-HT2A 0.163 5-HT2C 1.3 D1 >25 D2 >25 D3 >25 α1A >12 α2A 5.3 TAAR1 >15 H1 3.9 SERT 3.3 DAT >26 NET >22

Steroid hormone receptor (2,796 words) [view diff] exact match in snippet view article find links to article

binds androgens, and Thyroid Hormone and Trace Amine Associated Receptor 1 (TAAR1) binds Thyroid hormone (though not technically steroid hormones, thyroid

List of investigational antidepressants (11,184 words) [view diff] exact match in snippet view article find links to article

receptor 1 (TAAR1) agonist Ulotaront (SEP-363856; SEP-856) – serotonin 5-HT1A receptor agonist and trace amine-associated receptor 1 (TAAR1) agonist PRAX-114

Zolmitriptan (1,864 words) [view diff] exact match in snippet view article find links to article

EA, Hanratty L, Koblan KS, Foley A, Dedic N, Bristow LJ (August 2024). "TAAR1 and 5-HT1B receptor agonists attenuate autism-like irritability and aggression

DiPT (587 words) [view diff] exact match in snippet view article find links to article

Binding sites Binding affinity (Ki, μM) 5-HT1A 0.538 5-HT2A 1.2 5-HT2C 6.5 D1 >25 D2 >25 D3 >25 α1A >12 α2A 3.6 TAAR1 >15 H1 0.92 SERT 0.18 DAT 4.1 NET 8.9

Substituted β-hydroxyamphetamine (1,363 words) [view diff] exact match in snippet view article find links to article

4-fluoroephedrine are not agonists of the human trace amine-associated receptor 1 (TAAR1). With regard to medical and other uses, β-hydroxyamphetamines are employed

5-MeO-aMT (1,159 words) [view diff] exact match in snippet view article find links to article

Binding Sites Binding Affinity Ki (μM) 5-HT1A 0.046 5-HT2A 0.034 5-HT2C 0.09 D1 >25 D2 >25 D3 >25 α1A >12 α2A 11 TAAR1 1.1 H1 >25 SERT 12 DAT >26 NET >22

Mescaline (6,052 words) [view diff] exact match in snippet view article find links to article

4–8.9 α2B >10 α2C 0.75 β1 >10 β2 >10 D1 >14 D2 >10 D3 >17 D4 >10 D5 >10 TAAR1 3.3–11 (mouse/rat) I1 2.7 σ1 >10 σ2 >10 SERTTooltip Serotonin transporter

Mephedrone (12,257 words) [view diff] exact match in snippet view article find links to article

receptors, α2-adrenergic receptors, and trace amine-associated receptor 1 (TAAR1). Mephedrone administration leads to increased extracellular dopamine in

Psychedelic drug (9,054 words) [view diff] exact match in snippet view article find links to article

monoamine neurotransmission by binding to trace amine-associated receptor 1 (TAAR1), which plays a significant role in regulating neurotransmission in dopamine

Synthetic drug (2,877 words) [view diff] exact match in snippet view article find links to article

negative inotropism in isolated cardiac tissues of rats due to stimulation of TAAR1, which is in contrast with human pharmacology. Alprazolam binds to GABA

Bernard Lerer (1,613 words) [view diff] exact match in snippet view article find links to article

Bernard; Lifschytz, Tzuri (2022). "Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and