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searching for rNA-dependent RNA polymerase 104 found (275 total)

alternate case: RNA-dependent RNA polymerase

Valopicitabine (251 words) [view diff] exact match in snippet view article find links to article

progressed as far as Phase III clinical trials. It acts as an RNA-dependent RNA polymerase inhibitor. It is a prodrug which is converted inside the body

RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions

five open reading frames (ORFs) encoding five proteins: the RNA-dependent RNA Polymerase (RdRP), the movement proteins encoded by three overlapping ORFs

styrene. It is a promising model substance to inhibit SARS-CoV-2 RNA-dependent RNA polymerase. Bobbitt's salt pH neutral aqueous organic flow batteries Zakrzewski

RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions

45 nucleotides in length, which are converted into dsRNA by RNA-dependent RNA polymerase 2. Once cleaved by DCL3, the 24-nt siRNA strand is loaded into

segments, termed RNA1 and RNA2. The RNA1 segment encodes an RNA-dependent RNA polymerase (RdRP) of 982 amino acids. The RNA2 segment has two open reading

Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment. Some members of the family have ambisense

possibly auto-cleaved by the ORF2 viral protease. ORF3 encodes the RNA dependent RNA polymerase and may be translated by ribosomal frameshifting as an ORF2-ORF3

undergo generic reassortment, so no antigenic shift can occur. RNA-dependent RNA polymerase does not have a function to be able to check for errors in coding

(NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase / J. Virol. July 2005 vol. 79 no. 14 8687-8697 Schregel, V; Jacobi

responsible for encoding protein A, which is the RNA dependent RNA polymerase. RNA dependent RNA polymerase is necessary for replication of the nodamura virus

non structural membrane polypeptide and the L RNA encodes an RNA dependent RNA polymerase. The segmented RNAs are surrounded by nucleocapsid proteins that

2012:285481). His laboratory has shown how GTP binding to the viral RNA-dependent-RNA polymerase ensures accurate initiation of replication of the viral genome

(Darricarrere et al 2013). Though the mechanism is as of yet unclear, RNA-dependent RNA polymerase RrpC has been shown to post-transcriptionally silence retrotransposons

Shapi M (December 2020). "Discovery of Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: Virtual Screening, and Molecular Dynamics". International

indicating that the virus needs to bring their own enzyme, RNA-dependent RNA polymerase, in order to copy the negative strand into mRNA. This allows

strand synthesis. This mechanism is thought to be recognised by RNA-dependent RNA polymerase, found encoded within the genome. Viruses in Tombusviridae have

conserved domains: methyltransferase, protease, helicase and an RNA dependent RNA polymerase. RNA 2 encodes four ORFs which correspond to 15, 61, 32 and 24

This open reading frame encodes several modules including a RNA-dependent RNA polymerase. It is probably post translationally cleaved into several proteins

(S), Medium (M) and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins

yellow mosaic virus RNA in minus-strand synthesis by the viral RNA-dependent RNA polymerase". J Virol. 71 (8): 5990–5996. doi:10.1128/JVI.71.8.5990-5996

PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase". Antimicrobial Agents and Chemotherapy. 53 (6): 2544–52. doi:10

transcription from the negative-stranded genome by the viral RNA-dependent RNA polymerase to yield monocistronic mRNAs that code for the various viral

that correspond to the virion protein, helicase, protease, and RNA-dependent RNA polymerase domains of various picorna-like virus polyproteins. The increased

S. E.; et al. (1996). "Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus". The EMBO Journal. 15 (1): 12–22. doi:10

Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study". Life Sciences. 253: 117592

each virus. Like all other reoviruses, they contain their own RNA-dependent RNA polymerase, allowing for endogenous synthesis of viral mRNA within the virus

proteins: an RNA helicase, a chymotrypsin-like 3C protease and an RNA-dependent RNA polymerase. VP1 is encoded between codons 486 to 880 and VP3 lies between

et al. (July 2007). "Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity". Antimicrobial Agents and Chemotherapy. 51

has been shown to modulate the polymerase activity of NS5B, an RNA-dependent RNA polymerase (RdRp). Intriguingly, NS5A may be a RNA binding protein because

translated. This polypeptide has been characterized to be the RNA-dependent RNA polymerase (RdRp) and the VpG. This polypeptide is 977 amino acids in length

This polyprotein has methyl transferase, viral helicase and RNA dependent RNA polymerase domains. There are untranslated regions at the 5' and 3' ends

2006). "Identification of trans-acting siRNAs in moss and an RNA-dependent RNA polymerase required for their biogenesis". The Plant Journal. 48 (4): 511–21

glycoprotein, and L encodes for the polymerase. WCBV must encode for an RNA-dependent RNA polymerase (RdRp) in its genome in order for viral replication and synthesis

(S), Middle (M) and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins

2006). "Identification of trans-acting siRNAs in moss and an RNA-dependent RNA polymerase required for their biogenesis". Plant J. 48 (4): 511–21. doi:10

factors, EF-Tu & EF-Ts, the ribosomal protein subunit S1, and the RNA dependent RNA polymerase β-subunit. The two elongation factors form a heterodimer structure

(S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins

yellow mosaic virus RNA in minus-strand synthesis by the viral RNA-dependent RNA polymerase". Journal of Virology. 71 (8): 5990–5996. doi:10.1128/JVI.71

Institute, he further evolved this ribozyme to function as a RNA-dependent RNA polymerase to extend primers on external RNA templates, bolstering the "RNA

Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI (January 2005). "RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin

point. The core also contains within it twelve copies of λ3, the RNA-dependent RNA polymerase. One λ3 protein is found slightly offset from each of the twelve

transcription takes place in the host cell cytoplasm with the use of an RNA-dependent RNA polymerase, and enters replication after enough nucleoprotein has built

can occur. As a negative-strand RNA virus, GhV brings its own RNA-dependent RNA-polymerase with it into the cell. Three proteins are essential for GhV replication:

medium (M), and small (S) segments. The L segment encodes the RNA-dependent RNA polymerase, the M segment encodes two surface glycoproteins (Gn and Gc)

segments, the most in a known negative-sense RNA plant virus. The RNA-dependent RNA polymerase, glycoprotein precursor, nucleocapsid, and P4 proteins of WMoV

Singh, R. N., & Dreher, T. W. (1997). Turnip Yellow Mosaic Virus RNA-Dependent RNA Polymerase: Initiation of Minus Strand Synthesisin Vitro. Virology, 233(2)

fusion is complete, the viral genome, accessory proteins, and RNA dependent RNA polymerase are released into the host cell cytoplasm. Through in situ hybridization

articles Penhoet, E.; Miller, H.I.; Doyle, M.; Blatti, S. (1971). "RNA-dependent RNA polymerase in influenza virions". Proceedings of the National Academy of

PMID 12646228. Chen X, Feng Q, Wu Z, et al. (September 2003). "RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong"

protease into Gn, NSm and Gc proteins. The L RNA encodes the viral RNA dependent RNA Polymerase or L Protein The primary vectors of orthobunyaviruses are hematophagous

cellular RNAse function. L and P protein together forms viral RNA dependent RNA polymerase; where catalytic functions for RNA polymerization, capping and

; Fodor, Ervin (26 October 2015). "Crystal structure of the RNA-dependent RNA polymerase from influenza C virus". Nature. 527 (7576): 114–117. Bibcode:2015Natur

Double-stranded RNA makes mRNA and genomic RNA using RNA-dependent RNA polymerase

(2010). Molecular characterization of genome segment 2 encoding RNA dependent RNA polymerase of Antheraea mylitta cytoplasmic polyhedrosis virus. Archived

cleavage of the polyprotein encoded for by the genome. 3D is the RNA-dependent RNA polymerase (RdRP). 2B, 2C, and 3A are core viral proteins. The genome also

"Heat shock 70 protein interaction with Turnip mosaic virus RNA-dependent RNA polymerase within virus-induced membrane vesicles". Virology. 374 (1): 217–227

methyl transferase, PRO denotes proteinase, and RdRp indicates RNA-dependent RNA polymerase. Similar to other members of the crinivirus genus, ToCV is transmitted

three segments. The L segment encodes the L endonuclease (an RNA-dependent RNA polymerase enzyme) for genome replication and mRNA synthesis. The M segment

which then can be processed by the viral proteases to produce RNA dependent RNA polymerase (RdRp) and other structural proteins. The viral replication happens

RNA replication process The P2 protein encoded by ORF2 is the RNA-dependent RNA polymerase (RdRp) part of the replicase enzyme. Most likely, the P1 and

enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase". Journal of Virology. 77 (7): 4149–59. doi:10.1128/JVI.77.7

for nucleocapsid, phosphoprotein, matrix, glycoprotein, and an RNA-dependent RNA polymerase proteins. The rVSV-ZEBOV vaccine, known as Ervebo, was approved

ddhCTP (3ʹ-deoxy-3′,4ʹdidehydro-CTP), which inhibits the viral RNA dependent RNA polymerase (RdRp). ddhCTP also appears to abolish metabolism of amino acids

capping. RNA2 (2.9 kb) encodes the 2a protein (94 kDa), the RNA-dependent RNA polymerase, responsible for replication of the viral genome. The dicistronic

replication of a eukaryotic virus RNA in vitro by a purified RNA-dependent RNA polymerase". Cell. 63 (2): 363–368. doi:10.1016/0092-8674(90)90169-f. PMID 2208291

precursor in the open reading frame. The L segment encodes for an RNA-dependent RNA polymerase. Batai virus is geographically spread throughout Asia and Europe

methyltransferase domain at its N-terminal end (residues 1–296) and a RNA-dependent RNA polymerase (RdRp) at its C-terminal end (residues 320–900). The methyltransferase

DNA-dependent RNA polymerase. Shapiro was given the task of looking for RNA-dependent RNA polymerase using F2 RNA phage from Norton Zinder. She was successful in

have been designed in order to specifically target and amplify RNA-dependent RNA polymerase. This can be used to "partially characterize the Sapovirus and

coronavirus genome. This interaction enables the recruitment of RNA dependent RNA polymerase which is a protein used to make new RNA strands. Once RNA synthesis

phosphoproteins (P), which is an essential subunit of the viral of RNA-dependent RNA polymerase (RDRP), and the large protein (L) that is a catalytic subunit

Subsequently, genomic transcription occurs using the viruses own 'viral RNA-dependent RNA polymerase' (L protein). The cell's own ribosomes are then tasked with translation

tripartite genome. The longest segment of PMTV, RNA-rep encodes RNA dependent RNA polymerase and replicase subunits. The second segment, RNA-CP codes for

Challenge-Protective Vaccine Concept by Modification of the Viral RNA-Dependent RNA Polymerase of Canine Distemper Virus". Journal of Virology. 81 (24): 13649–13658

and L proteins. The L protein most likely represents the viral RNA-dependent RNA polymerase. When the cell is infected by the virus, L polymerase is associated

Utilised for host cell entry with receptor-mediated endocytosis L RNA dependent RNA polymerase Enzyme for transcription (produce mRNA from genome) and viral

(2020). "Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high

The viral RNA is replicated into a dsRNA genome utilizing an RNA dependent-RNA polymerase. The newly synthesized dsRNA is used to both transcribe more

SARS-CoV-2, simeprevir acts by inhibiting Main protease (Mpro) and RNA-dependent RNA polymerase, a non-structural protein, essential for viral RNA synthesis

SUMO-Conjugating Enzyme in Plants That Interacts with NIb, the RNA-Dependent RNA Polymerase of Turnip Mosaic Virus, Is Required for Viral Infection". Journal

of 242 k-Da and interacts with the phosphoprotein to form the RNA-dependent RNA polymerase complex. L and P bind to each other and according to current

The viral genome is replicated via structural protein VP1, an RNA-dependent RNA polymerase. The lack of proof-reading abilities results in high levels of

L-segment RNA is approximately 7.2 kb, and encodes the viral RNA-dependent RNA-polymerase (L) and a small RING-domain containing protein (Z). The Z protein

enzymatic activity as a helicase and protease, while NS5 is an RNA dependent RNA polymerase, allowing the virus to replicate a new (+)RNA genome by creating

NITD008 has been reported to directly inhibit the recombinant RNA-dependent RNA polymerase of the dengue virus by terminating its RNA chain synthesis. This

immune responses. The large genome segment (L) encodes for an RNA-dependent RNA polymerase, which is essential in carrying out replication and transcription

to target ZFP62 is named Artenimol, which would inhibit the RNA-dependent RNA polymerase activity of ZFP62, which is known to be an effective mechanism

NS5B (p75), which features a functional motif typical of viral RNA-dependent RNA polymerase, is roughly 77 kDa in size (RdRp). It primarily participates

Kimura, Hirokazu (2018). "Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II". Frontiers in Microbiology

factors. Segment B contains genetic information for creating an RNA-dependent RNA polymerase enzyme made of VP1. The composition of the surface of virus particles

Brueckner F, Cramer P (November 2007). "Molecular basis of RNA-dependent RNA polymerase II activity". Nature. 450 (7168): 445–449. Bibcode:2007Natur

Hamilton, A.; Rudd, S.; Angell, S.; Baulcombe, D. (2000). "An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene

allows extracellular zinc to enter the cell and inhibit viral RNA-dependent RNA polymerase. Chloroquine inhibits thiamine uptake. It acts specifically on

protein variants. Viral RNAs are transcribed by a virus-encoded RNA-dependent RNA polymerase, which is prone to pausing and "stuttering" at certain nucleotide

Martha Stampfer discovered that VSV replication involved an RNA-dependent RNA polymerase within the virus particle, and used a novel strategy to replicate

mechanism for RNA recombination in RNA viruses where the viral RNA-dependent RNA polymerase switches templates during negative strand synthesis. Host genomes

Seshadri V, Dorweiler JE, White J, et al. (July 2006). "An RNA-dependent RNA polymerase is required for paramutation in maize". Nature. 442 (7100): 295–298

double-stranded RNA (dsRNA) genome. After entering a host cell, the viral RNA-dependent RNA polymerase (RdRp) synthesizes a positive-sense strand from the negative-sense

RNA-guided RNase VI-A Cas13a (C2c2) VI-B Cas13b VI-C Cas13c VI-D Cas13d VI-X Cas13x.1 RNA dependent RNA polymerase, Prophylactic RNA-virus inhibition VI-Y

protein at the ribosomes, as at least one copy of the viral RNA-dependent RNA polymerase is required for the replication of the RNA. After this has synthesized

Hannoun, C. (1976). "Studies on lumbo virus replication. I. RNA-dependent RNA polymerase associated with virions". Virology. 69 (1): 258–264. doi:10

hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase". Journal of Biological Chemistry. 290 (36): 22310. doi:10.1074/jbc