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searching for gTPase 376 found (1341 total)

alternate case: GTPase

RRAD (gene) (950 words) [view diff] exact match in snippet view article

that in humans is encoded by the RRAD gene. RRAD is a Ras-related small GTPase that is regulated by p53 and plays a role in the regulation of aerobic glycolysis

the Rho family, which is part of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, two tandem BTB (broad complex

factor 5 is a protein that in humans is encoded by the EIF5 gene. EIF5 is a GTPase-activating protein. GRCh38: Ensembl release 89: ENSG00000100664 – Ensembl

(impaired bile flow) diseases. Downstream of LPA receptor activation, the small GTPase Rho can be activated, subsequently activating Rho kinase. This can lead

Haataja L, Kaartinen V, Groffen J, Heisterkamp N (March 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin

protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in signaling pathways, which act to regulate

Artigiani S, Settleman J, Comoglio PM, Tamagnone L (Oct 2005). "p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin

"Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases". EMBO J. 25 (16): 3750–61. doi:10.1038/sj.emboj.7601274. PMC 1553191.

GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a

GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a

activity and is a guanine nucleotide exchange factor for the Rho family of GTPases including RhoA. A reciprocal translocation between chromosomes 22 and 9

X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 is a protein in the ciliary transition zone that in humans is encoded by the RPGRIP1

"Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". J. Cell Sci. 109 (3): 653–61. doi:10

IQ motif containing GTPase activating protein (IQGAP) is a carrier protein. It is associated with the Rho GTP-binding protein. IQGAP1, IQGAP2, IQGAP3 IQ

nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. The OPA1 protein localizes

RHOBTB2 is a member of the evolutionarily-conserved RhoBTB subfamily of Rho GTPases. For background information on RhoBTBs, see RHOBTB1 (MIM 607351).[supplied

been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of

represented as a family of four closely bound GAPs1 (GTPase-activating proteins). These small GTPases were once characterized as high affinity intracellular

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene. ARHGAP1 has been shown to interact with: BNIP2 CDC42, and RHOA

similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene. This gene encodes a member of the sorting nexin family.

a protein which in humans is encoded by the CHN1 gene. Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed

non-small cell lung cancer. Adagrasib is an inhibitor of G12C mutated KRAS GTPase. It is taken by mouth. It is being developed by Mirati Therapeutics. The

Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1

is a guanine-nucleotide exchange factor (GEF) that can activate the Rho GTPase Cdc42. It localizes preferentially to the trans-Golgi network (TGN) of mammalian

Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS that are expressed primarily

signalling 19". Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell

family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein

phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific

G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is

1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological

Hu G, Wensel TG (2002). "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9755–60

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene. The protein encoded by this gene is member of the GAP1 family

protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating

has some activity as a cytotoxin. The toxin acts by modifying host cell GTPase proteins by glucosylation, leading to changes in cellular activities. Risk

has some activity as a cytotoxin. The toxin acts by modifying host cell GTPase proteins by glucosylation, leading to changes in cellular activities. Risk

negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex

protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins

are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. RGS5 has been shown to interact with GNAO1, GNAI2 and GNAI3

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene. This gene encodes a member of the GIT protein family. GIT proteins

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript variants encoding different

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene. Rho GTPase activating protein 5 negatively regulates RHO GTPases

ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene. GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting

NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg2+-binding site (Walker A and B motifs, respectively)

responsible for various forms of cancer. Sotorasib is an inhibitor of the RAS GTPase family. The most common side effects include diarrhea, musculoskeletal pain

mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling

where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene

was originally known as TBC1 domain family member 4 (TBC1D4), is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene. The 160

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene. CENTG1 has been shown to interact

SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by

for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with

guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases. The gene was so named because the Sos protein that it encoded was found

the RAB11A gene. The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene. It belongs to rabaptin protein family. RABEP1 has been

unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled

et al. (1998). "High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5351–6

GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene. GAPVD1

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. This gene encodes one of the DNA-unwinding enzymes

functions as a GTPase Activating Protein (GAP) which acts to increase the natural GTPase activity of the Gα subunit. By increasing the GTPase activity of

Rho GTPase activating protein 44 is a protein in humans that is encoded by the ARHGAP44 gene. GRCh38: Ensembl release 89: ENSG00000006740 – Ensembl, May

protein-signaling GTPase-activating protein activity". J Biol Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990. Ross EM, Wilkie TM (2000). "GTPase-activating

SLIT-ROBO Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the SRGAP1 gene. GRCh38: Ensembl release 89: ENSG00000196935 – Ensembl

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene. This gene encodes a protein that contains the GAP-related

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene. GRCh38: Ensembl release 89: ENSG00000138639 – Ensembl, May

in humans is encoded by the CDC42EP1 gene. CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization

encoded by the SIPA1 gene. The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related

encoded by the SIPA1 gene. The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related

contains a GTPase Activating Protein (GAP) domain which has been shown to stimulate (down regulate) the GTPase activity of the small GTPase Rheb, which

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene. This gene encodes a member of the GAP1 family of GTPase-activating

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene. RAP1GAP has been shown to interact with MLLT4. GRCh38: Ensembl

guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide

Rab3 GTPase-activating protein catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP1 gene. Members of the RAB3 protein family (see RAB3A;

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene. This gene encodes a member of the IQGAP family. The

et al. (2007). "Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4". Am. J. Hum. Genet. 81

GPN-loop GTPase 3 is an enzyme that in humans is encoded by the GPN3 gene. GRCh38: Ensembl release 89: ENSG00000111231 – Ensembl, May 2017 GRCm38: Ensembl

Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene. Rho GTPases control a variety of cellular processes. There

In molecular biology, the interferon-inducible GTPase (IIGP) family of proteins is thought to play a role in intracellular defence. IIGP is predominantly

Mitochondrial GTPase 1 is an enzyme that in humans is encoded by the MTG1 gene. GRCh38: Ensembl release 89: ENSG00000148824 – Ensembl, May 2017 GRCm38:

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene. This gene encodes a GTPase-activating protein that activates

"PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2). United States: 541–7. doi:10

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene. GRCh38: Ensembl release 89: ENSG00000196220 – Ensembl

Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme that in humans is encoded by the AGAP1 gene. CENTG2 belongs to an ADP-ribosylation

PMID 14702039. Harrington AW, Kim JY, Yoon SO (2002). "Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis". J.

G, Camonis JH (Oct 1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J Biol Chem

guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide

RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene. GRCh38: Ensembl release 89: ENSG00000011454 – Ensembl, May

GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene. This gene encodes a member of the RHOGAP family. GAP (GTPase-activating)

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene. RAP1GDS1 has been shown to interact with KIFAP3

guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell motility and axonal outgrowth

up rnd in Wiktionary, the free dictionary. Rnd may refer to: Rnd (GTPase) Rnd (GTPase) Rnd (trigraph) Ruund language (ISO 639:rnd) RND (disambiguation)

Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science. 292 (5520): 1373–6

that in humans is encoded by the DAB2IP gene. DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated

cytokinesis 4". Yajnik V, Paulding C, Sordella R, et al. (March 2003). "DOCK4, a GTPase activator, is disrupted during tumorigenesis". Cell. 112 (5): 673–684. doi:10

(ERGIC, in mammals). Coat assembly is initiated when the cytosolic Ras GTPase Sar1 is activated by its guanine nucleotide exchange factor Sec12. Activated

with Rabaptin5 C-terminal Domain 1tu4: Crystal Structure of Rab5-GDP Complex 1z07: GppNHp-Bound Rab5c G55Q mutant GTPase 1z0d: GDP-Bound Rab5c GTPase

member 3 ABR: encoding protein Abr, rhogef and gtpase activating protein ARHGAP44: encoding protein Rho GTPase activating protein 44 AZI1: encoding protein

G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as KAIA0053. ARHGAP25 belongs to a

guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide

Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ARHGAP19 gene. GRCh38: Ensembl release 89: ENSG00000213390 – Ensembl, May

Rho GTPase activating protein 18 is a protein that in humans is encoded by the ARHGAP18 gene. The gene is also known as MacGAP and bA307O14.2. ARHGAP18

domain is a critical determinant of response of Raf to Ras family small GTPases". Molecular and Cellular Biology. 19 (9): 6057–64. doi:10.1128/mcb.19.9

GRAMD9. It is predicted to enable GTPase activator activity. It is also predicted to be involved in activation of GTPase activity and intracellular protein

Mitochondrial Rho GTPase 1 (MIRO1) is an enzyme that in humans is encoded by the RHOT1 gene on chromosome 17. As a Miro protein isoform, the protein facilitates

GTPase involved in membrane traffic. There are 6 mammalian ARFs which are regulated by over 30 guanine nucleotide exchange factors (GEFs) and GTPase activating

Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (Oct 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma

that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1". The Biochemical Journal. 340 (2): 359–63. doi:10

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. This gene encodes a member of a large family of proteins

homolog to the ELMO protein found in mammals. This protein is involved in Rac-GTPase activation, apoptotic cell phagocytosis, cell migration, and cytoskeletal

GTPase IMAP family member 4 is an enzyme that in humans is encoded by the GIMAP4 gene. This gene encodes a protein belonging to the GTP-binding superfamily

sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases". J Biol Chem. 284 (32): 21580–8. doi:10.1074/jbc.M109

SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family". Journal of Biochemistry. 130 (1): 23–31

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene. GRCh38: Ensembl release 89:

Gene ontology Molecular function metal ion binding small GTPase binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol

2 isoforms through alternative splicing. M-Ras is a member of the small GTPase superfamily under the Ras family, which also includes Rap1, Rap2, R-Ras

protein that in humans is encoded by the CDC42EP3 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction

GTP binding GTPase activity signaling receptor binding G protein-coupled serotonin receptor binding mu-type opioid receptor binding GTPase activating protein

GDI1 have been linked to X-linked nonspecific mental retardation. Rab GTPases cycles between the cytosolic compartment, where it is bound to a protein

GTPase IMAP family member 5 is an enzyme that in humans is encoded by the GIMAP5 gene. This gene encodes a protein belonging to the GTP-binding superfamily

Bokhoven H, Ginsel LA, Fransen JA (Oct 2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein

ARHGAP29 is a gene located on chromosome 1p22 that encodes Rho GTPase activating protein (GAP) 29, a protein that mediates the cyclical regulation of small

Newman, L. E.; Schiavon, C. R.; Turn, R. E.; Kahn, R. A. (2017). "The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space". Cellular Logistics

"The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl

ras-related GTPase". EMBO J. 12 (1): 339–47. doi:10.1002/j.1460-2075.1993.tb05662.x. PMC 413211. PMID 8094051. Urano T, Emkey R, Feig LA (1996). "Ral-GTPases mediate

"Dock180–ELMO Cooperation in Rac Activation". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 388–402. doi:10

HBS1 like translational GTPase is a protein that in humans is encoded by the HBS1L gene. This gene encodes a member of the GTP-binding elongation factor

Large subunit GTPase 1 homolog is an enzyme that in humans is encoded by the LSG1 gene. GRCh38: Ensembl release 89: ENSG00000041802 – Ensembl, May 2017

member RAS oncogene family". Chen D, Guo J, Gahl WA (January 1997). "RAB GTPases expressed in human melanoma cells". Biochimica et Biophysica Acta. 1355

Bub2p, and Cdc16p) domain, which is found in proteins involved in Rab GTPase signaling and vesicle trafficking. There are two copies of this gene located

Rho-GAP domain (amino acids 639-847) functions to enhance the GTPase activity of the Rho-GTPase proteins RhoA and Cdc42, promoting the hydrolysis of their

Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol

binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown

Large subunit GTPase 1 homolog is an enzyme that in humans is encoded by the LSG1 gene. GRCh38: Ensembl release 89: ENSG00000041802 – Ensembl, May 2017

Rho GTPase activating protein 21 is a protein that in humans is encoded by the ARHGAP21 gene. ARHGAP21 functions preferentially as a GTPase-activating

development positive regulation of GTPase activity cell surface receptor signaling pathway negative regulation of GTPase activity neuron differentiation

G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain". The EMBO Journal. 7 (4): 1175–82. doi:10.1002/j.1460-2075.1988

Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol

Bub2p, and Cdc16p) domain, which is found in proteins involved in Rab GTPase signaling and vesicle trafficking. There are two copies of this gene located

SL, Dufresne CP, Cowell JK (Apr 2007). "The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11". Oncogene. 26 (19): 2804–8. doi:10.1038/sj

Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene. G3BP2 has been shown to interact with IκBα. GRCh38:

PMID 16118622. Carmona G, Göttig S, Orlandi A, et al. (2009). "Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis"

PDE6D has been shown to interact with: ARL2 HRAS RAP1A Retinitis pigmentosa GTPase regulator Rnd1 GRCh38: Ensembl release 89: ENSG00000156973 – Ensembl, May

Aliases ARHGAP45, HA-1, HLA-HA1, HMHA1, histocompatibility (minor) HA-1, Rho GTPase activating protein 45 External IDs OMIM: 601155; MGI: 1917969; HomoloGene:

positive regulation of endothelial cell migration positive regulation of GTPase activity positive regulation of intracellular protein transport transcription

dissociates from the trimer and associates to an effector until the intrinsic GTPase activity of G-alpha returns the protein to GDP bound form. Reassociation

domains. The protein is a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases. STARD8 is characterized

resulting signal can activate intracellular effectors like ERKs, Rho GTPase, Rac GTPase, PLC, and AKT/PI3K. It can also exert its effect on target molecules

homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087–95

ADP ribosylation factor like GTPase 13A is a protein that in humans is encoded by the ARL13A gene. GRCh38: Ensembl release 89: ENSG00000174225 – Ensembl

protein that in humans is encoded by the CDC42EP2 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction

cytotoxins that cause constitutive activation of Rho guanosine triphosphatases (GTPases), which are key regulators of the actin cytoskeleton . Bordetella dermonecrotic

disassembled. The small GTPase RhoA has been shown to be implicated, controlling CR assembly and dynamics during cytokinesis. This GTPase cycles between an

arfaptin domain is a protein domain which interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory

GTPase-activating Rap/Ran-GAP domain-like 1 is an enzyme that in humans is encoded by the RALGAPA1 gene. GRCh38: Ensembl release 89: ENSG00000174373 –

150.500 – ras gtpase-activating proteins MeSH D12.776.476.325.150.500.460 – neurofibromin 1 MeSH D12.776.476.325.150.500.500 – p120 gtpase activating protein

activated PYK2. In vitro it shows strong GTPase-activating protein (GAP) activity towards the small GTPases ADP-ribosylation factor (ARF) 1 and ARF5 and

STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases. It selectively activates

and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc

binding transmembrane signaling receptor activity signal transducer activity GTPase activator activity Cellular component integral component of membrane plasma

promoting the release of GDP from Rac and RhoA, it acts as an activator of GTPase signaling within the cell. Although able to activate Rac and RhoA, much

Molecular function Rab GDP-dissociation inhibitor activity GTPase activator activity small GTPase binding protein binding GDP-dissociation inhibitor activity

Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. Bibcode:2004Sci

nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature

mitofusin 1". Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9

growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre". The Journal of Biological Chemistry. 277 (52):

pathway. An example of this can be seen in the lipid anchoring of the Rho GTPase family of signaling molecules and the gamma subunit of heterotrimeric G

Van Der Sluijs P (Mar 2000). "Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles". The Biochemical

regulation of GTPase activity intracellular protein transport protein geranylgeranylation regulation of catalytic activity small GTPase mediated signal

encoded by the XPOT gene. This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm

GAPs may also refer to: Gaps (album), an album by Monster Bobby GAPs or GTPase activating protein, a protein molecule GAPS or General Antiparticle Spectrometer

Rowe T (2005). "TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7". Biochem. Biophys

regulation of GTPase activity intracellular protein transport protein geranylgeranylation regulation of catalytic activity small GTPase mediated signal

Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. Bibcode:2004Sci

GAPs may also refer to: Gaps (album), an album by Monster Bobby GAPs or GTPase activating protein, a protein molecule GAPS or General Antiparticle Spectrometer

encoded by the XPOT gene. This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm

National Library of Medicine. Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6

activation, lectin pathway regulation of small GTPase mediated signal transduction positive regulation of GTPase activity negative regulation of endopeptidase

Cooper JA, Randazzo PA (December 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Molecular

JF, Yang Y, Yoo JS, Lee JD (Jan 2003). "ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation"

phospholipase C-beta; but the GRK2 and GRK3 RH domains are unable to function as GTPase-activating proteins (as do traditional RGS proteins) to turn off G protein

GUF1 homolog, GTPase is a protein that in humans is encoded by the GUF1 gene. It is the mitochondrial homolog of elongation factor 4. GRCh38: Ensembl release

of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro

Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 and Ccdc42". J Biol Chem. 275 (46): 36457–64

the RASGRP3 gene. Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle

architecture in the cell. For the Rac branch, DVL activates the Rac GTPase. Activating the Rac GTPase stimulates the downstream effector c-Jun N-terminal kinase

biochemist known for research on chromosome segregation and the discovery of Ran GTPase. She is the acting scientific director of the division of intramural research

Suzuki N, Nakamura S, Hartwig JH, Stossel TP (March 1999). "The small GTPase RalA targets filamin to induce filopodia". Proc. Natl. Acad. Sci. U.S.A

PMID 16650381. Hofmann I, Munro S (2006). "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility". J. Cell Sci. 119

and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114

domains, including an N-terminal domain, a GTPase domain, a linker region, C1, C2, and C-terminal domains. The GTPase domain encompasses the G1-G5 motif, which

Gene ontology Molecular function GTPase activator activity syntaxin-1 binding syntaxin binding myosin II binding Cellular component integral component

a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site

elongation factor activity nucleotide binding GTP binding protein binding GTPase activity Cellular component mitochondrial matrix mitochondrion Biological

Fc-gamma receptor signaling pathway involved in phagocytosis regulation of GTPase activity T cell costimulation neutrophil chemotaxis reactive oxygen species

GN (September 1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9

proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc

Gunzburg J (2003). "A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases". Biochem. J. 367 (Pt 1): 57–65

Sinha S, Yang W (November 2008). "Cellular signaling for activation of Rho GTPase Cdc42". Cellular Signalling. 20 (11): 1927–34. doi:10.1016/j.cellsig.2008

stimulus vesicle transport along microtubule activation of GTPase activity regulation of GTPase activity cytokine production positive regulation of Ras protein

Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278

"Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity". J. Biol

Zhang Q, et al. (2007). "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis". Cell. 129 (6): 1201–13. doi:10

structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7909–14

Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component cytoplasm centrosome intracellular anatomical structure

localization of human rab5b, a new member of the ras-related superfamily of GTPases". J Clin Invest. 89 (3): 996–1005. doi:10.1172/JCI115683. PMC 442949. PMID 1541686

ARL3 Identifiers Aliases ARL3, ARFL3, ADP ribosylation factor like GTPase 3, JBTS35, RP83 External IDs OMIM: 604695; MGI: 1929699; HomoloGene: 48276; GeneCards:

encoded by the OPHN1 gene. Oligophrenin 1 has 25 exons and encodes a Rho-GTPase-activating protein. The Rho proteins are important mediators of intracellular

belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal

1093/dnares/8.4.179. PMID 11572484. "Entrez Gene: RHPN1 rhophilin, Rho GTPase binding protein 1". Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards

that functions as a guanine nucleotide exchange factor (GEF) for small GTPases of the Rho family, and specifically Rac and Cdc42. Like other GEFs, αPIX

PMID 11230166. Zheng JY, Koda T, Fujiwara T, et al. (1998). "A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae"

those of human Rubicon and PLEKHM1 mediate interaction with the small GTPase Rab7, which is found on late endosomes and autophagosomes. RH domains contain

Gene ontology Molecular function GTPase activator activity histone acetyltransferase activity enzyme inhibitor activity insulin-like growth factor receptor

Okamoto I, Miki T (Dec 1999). "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis". J. Cell Biol

localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. GRCh38: Ensembl release 89: ENSG00000151239 – Ensembl, May 2017 GRCm38:

process actin cytoskeleton reorganization activation of GTPase activity regulation of GTPase activity ephrin receptor signaling pathway regulation of

the RAB18 gene. It is a member of the Rab family of Ras-related small GTPases. Rab18 is a ubiquitously expressed protein with particularly high expression

trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The

Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10

PMID 8617742. Best A, Ahmed S, Kozma R, Lim L (Feb 1996). "The Ras-related GTPase Rac1 binds tubulin". The Journal of Biological Chemistry. 271 (7): 3756–62

Gene ontology Molecular function protein binding GTPase activator activity Cellular component nuclear membrane membrane nucleoplasm nucleus intracellular

Gravel RA, Oppermann U, Yue WW (December 2010). "Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into

Yamamoto H, Suetsugu S, Miki H, Takenawa T, Endo T (Feb 2003). "Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes

The enzyme dGTPase (EC 3.1.5.1) catalyzes the reaction dGTP + H2O ⇌ {\displaystyle \rightleftharpoons } deoxyguanosine + triphosphate This enzyme belongs

domains function to activate small GTPases of the Rho family by facilitating release of GDP from an inactive Rho GTPase and binding of GTP to activate it

production positive regulation of GTPase activity positive regulation of blood pressure cell adhesion negative regulation of GTPase activity bicellular tight

is recruited to its sites of action through interaction with the small GTPase Rab7, and impairs the autophagosome-lysosome fusion step of autophagy through

113.23.4165. PMID 11069762. Richnau N, Aspenström P (2001). "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42

homolog to the ELMO protein found in mammals. This protein is involved in Rac-GTPase activation, apoptotic cell phagocytosis, cell migration, and cytoskeletal

formation. Two UvrA proteins form a homodimer (UvrA2) and they both have ATPase/GTPase activity. Two UvrB proteins form a homodimer (UvrB2). The UvrA homodimer

guanine nucleotide exchange factor (GEF) activity specific to Rab5 and a GTPase activating protein (GAP) activity specific to RAS. The original GeneBank

have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac. TD-60 has also been shown to interact with the Chromosomal Passenger

channel regulator activity signal transducer activity protein binding GTPase activity GTPase binding Cellular component cytoplasm cell body vesicle membrane

Gene ontology Molecular function protein binding GTPase activator activity GTPase activity Cellular component plasma membrane membrane nucleus nucleoplasm

Casey PJ, Peralta EG (1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. Bibcode:1996Natur.383..175H. doi:10

Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent

protein-containing complex binding signal transducer activity protein binding GTPase activity GTPase binding G protein-coupled receptor binding alkylglycerophosphoethanolamine

GTPase activator activity Cellular component cellular component Biological process positive regulation of GTPase activity regulation of small GTPase mediated

microtubules of the central spindle. MKLP1, together with the Rho-family GTPase activating protein CYK-4 (also termed MgcRacGAP), forms the centralspindlin

Gene ontology Molecular function GTPase binding spectrin binding protein binding signal transducer activity GTPase activity Cellular component cell body

leukemia) ANKRD22: encoding protein Ankyrin repeat domain 22 ARHGAP21: rho GTPase activating protein 21 ARID5B: encoding protein AT-rich interactive domain-containing

1074/jbc.M203569200. PMID 12221077. "Entrez Gene: RHPN2 rhophilin, Rho GTPase binding protein 2". Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H

Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr

Activity of DHR-2/DOCKER/CZH2 Domains". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 41–57. doi:10

GTPase". EMBO J. 24 (12): 2064–74. doi:10.1038/sj.emboj.7600699. PMC 1150893. PMID 15920473. Chien Y, Kim S, Bumeister R, et al. (2006). "RalB GTPase-mediated

RIT2 gene. RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM] RIT2 has been associated with Parkinson's

PMID 10893222. Bielli A, Thörnqvist PO, Hendrick AG, et al. (2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate

that in humans is encoded by the RAB11FIP3 gene. Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting

GTP binding protein binding GTPase activity magnesium ion binding GDP binding protein heterodimerization activity GTPase binding Cellular component cytoplasm

that functions as a guanine nucleotide exchange factor (GEF) for small GTPases of the Rho family, and specifically Rac and Cdc42. Like other GEFs, βPIX

Gene ontology Molecular function GTPase activator activity protein binding enzyme binding phospholipid binding guanyl-nucleotide exchange factor activity

"Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The

PMID 15998911. Itoh T, Fukuda M (2006). "Identification of EPI64 as a GTPase-activating protein specific for Rab27A". J. Biol. Chem. 281 (42): 31823–31

X, Ritacco C, Lambright DG (2005). "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5". Nature. 436 (7049): 415–9. Bibcode:2005Natur

ADP ribosylation factor like GTPase 6 interacting protein 6 is a protein that in the humans is encoded by the ARL6IP6 gene. It spans from 152,717,893 to

(March 1996). "Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization". Cell. 84 (5): 723–34. doi:10

Biological process regulation of GTPase activity small GTPase mediated signal transduction positive regulation of GTPase activity Ras protein signal transduction

binding protein binding metal ion binding G protein-coupled receptor binding GTPase activity signal transducer activity G-protein beta/gamma-subunit complex

(Mar 2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". The Journal of Biological Chemistry. 280 (11):

this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic

late endosome to Golgi transport positive regulation of GTPase activity activation of GTPase activity regulation of vesicle fusion intracellular protein

PMID 8125298. Lütcke A, Jansson S, Parton RG, et al. (1993). "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization"

(Turkish: Cumhuriyet Halk Partisi) Collagen hybridizing peptide CHP (gene) Chp (GTPase) Cumene hydroperoxide Capillary hydrostatic pressure, a component of the

ligand-binding domain of the Nogo receptor. Another beta bend ribbon occurs in the GTPase-activating protein for Rho in the active, but not the inactive, form of

Activity of DHR-2/DOCKER/CZH2 Domains". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 41–57. doi:10

nucleotide exchange activity that converts GDP on the Rho family Small GTPase (RhoGTPase) to GTP, and PLEKHG2 having this domain also acts as a Rho-specific

involved in various activities like controlling GTPase, breaking down certain molecules, and binding to small GTPase. It helps in fighting bacteria and regulating

Xretinitis pigmentosa 2 (X-linked recessive), ARL3 GTPase activating protein, RP2 activator of ARL3 GTPase External IDs OMIM: 300757; MGI: 1277953; HomoloGene:

sapiens (See RANGAP1) and the plant Arabidopsis thaliana, it acts as a GTPase-activating protein, catalysing the conversion of cytosolically-bound RanGTP

Lu L, Tai G, Hong W (2004). "Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network".

X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences

Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10

National Library of Medicine. Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6

(2007). "Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1". Biochem. J. 403 (2): 353–8. doi:10.1042/BJ20061798

spermatogenesis regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity inositol phosphate dephosphorylation

guanyl-nucleotide exchange factor activity protein binding GTPase activator activity GTPase binding Cellular component integral component of membrane endoplasmic

"Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell

proteins such as the syntaxin homolog Vam3, SNAP-25 homolog Vam7, Ras-like GTPase Ypt7, and the NSF ortholog, Sec18. Several complexes are known to flexibly

Transnational College of Lex, a language research institution based in Japan TCL (GTPase), in biochemistry. Tibial collateral ligament, one of the four major ligaments

"ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". Journal of Cell Science

receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity Cellular component acrosomal vesicle cytoplasm axoneme heterotrimeric

RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins

"Dock180–ELMO Cooperation in Rac Activation". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 388–402. doi:10

nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885

CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively

S2CID 12247592. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II". Neuron. 20

agricultural practice, any collection of value-based agricultural practices GTPase-activating proteins, a family of regulatory proteins Gap, accidental gap

cyclase activity regulation of protein localization positive regulation of GTPase activity ATP metabolic process negative regulation of acute inflammatory

Thomason DB (August 2002). "Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy". American Journal of Physiology

organization and dynamics of the cytoskeleton, as well as the regulation of Rho-GTPase family. CGNL1 was originally discovered in 1997 as a 155 kDa protein localized

Fontaine JJ, Hellio R, Tavitian A, Louvard D (Feb 1994). "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes

function calcium ion binding heparin binding protein homodimerization activity GTPase inhibitor activity laminin-1 binding protein binding identical protein binding

adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858

maintenance negative regulation of protein kinase activity activation of GTPase activity phosphorylation transmembrane receptor protein tyrosine kinase

S2CID 12247592. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II". Neuron. 20

function calcium ion binding heparin binding protein homodimerization activity GTPase inhibitor activity laminin-1 binding protein binding identical protein binding

agricultural practice, any collection of value-based agricultural practices GTPase-activating proteins, a family of regulatory proteins Gap, accidental gap

Gene ontology Molecular function GTPase activator activity protein binding lyase activity enzyme binding 3-hydroxyacyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA

Rho-related GTPases from plants, otherwise known as ROPs, are involved in cell polarity through the regulation of cytoskeleton components like actin and

blood circulation neutrophil chemotaxis chemotaxis positive regulation of GTPase activity cellular response to interleukin-1 immune response positive regulation

PMC 528928. PMID 15489334. Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates

Molecular function GTPase activator activity SH3 domain binding kinase binding protein binding protein kinase binding small GTPase binding Cellular component

(recessive) (see OMIM 165500). The OPA1 gene codes for a dynamin-related GTPase protein targeted to the mitochondrial inner membrane. OPA1 has distinct

Biological process regulation of GTPase activity intracellular signal transduction signal transduction positive regulation of GTPase activity negative regulation

Pretty Cure Ran (star) or Epsilon Eridani, a star Ran (protein), a small GTPase that is involved in import and export within a cell nucleus as well as mitosis

JJ, Blackshaw S, Ferris CD, Snyder SH (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell

the Rho family of GTPases and specifically regulate the activity of Cdc42 and Rac1. Autosomal dominant mutations in ARHGAP31 (a GTPase-activating protein)

homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage. This domain

PE, Gas N, Jacquier A, Fromont-Racine M (Nov 2001). "Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps"

functions as a guanine nucleotide exchange factor for the Ras-like small GTPase Rap upon cAMP stimulation. Epac2 is involved in a variety of cAMP-mediated

L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151

regulation of NMDA receptor activity activation of GTPase activity cell population proliferation small GTPase mediated signal transduction positive regulation

ARL15 Identifiers Aliases ARL15, ARFRP2, ADP ribosylation factor like GTPase 15 External IDs MGI: 2442308; HomoloGene: 56843; GeneCards: ARL15; OMA:ARL15

factor 5 is a protein that in humans is encoded by the ARHGEF5 gene. Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular

Horisberger MA (Aug 1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". Journal of Virology. 66 (8):

transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases". Cellular Signalling. 19 (11): 2388–99. doi:10.1016/j.cellsig.2007.07

binding GTP binding translation release factor activity protein binding GTPase activity RNA binding Cellular component cytoplasm cytosol translation release

of mammalian ribosomal protein complex P0.P1.P2 and protein L12 to the GTPase-associated domain of 28 S ribosomal RNA and effect on the accessibility

L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol. 151

Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2"

protein has been shown to bind a CRK-associated substrate, a nephrocystin, a GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein

suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nat. Cell Biol. 2 (5): 281–7. doi:10.1038/35010550. PMID 10806479

ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity translation elongation factor activity RNA binding Cellular component

regulate the N-terminal conventional ATPase domain PseudoGTPase Allosteric regulator of conventional GTPase GTP-bound Rnd1 or Rnd3/RhoE bind p190RhoGAP to regulate

(1993). "A GTPase Cycle in Initiation of Protein Translocation Across the Endoplasmic Reticulum Membrane". Ciba Foundation Symposium 176 - the GTPase Superfamily

"PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000

Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange

"Dock180–ELMO Cooperation in Rac Activation". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 388–402. doi:10

As well as activating GTPases (GEF), the same C9ORF72-SMCR8-WDR41 complex is proposed to inactivate GTPases, i.e. as a GTPase-activating protein (GAP)

Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal

C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation". The EMBO Journal. 20 (9): 2326–2337. doi:10.1093/emboj/20.9

translation factor activity, RNA binding protein binding protein kinase binding GTPase activity translation elongation factor activity Cellular component myelin

Paquola AC, et al. (2004). "RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors". Biochem. Biophys. Res

metabotropic glutamate receptor binding protein binding hydrolase activity GTPase activity microtubule binding identical protein binding structural constituent

dentin-containing tooth cell-substrate adhesion positive regulation of GTPase activity cell adhesion cell adhesion mediated by integrin brown fat cell

ontology Molecular function protein binding signal transducer activity GTPase activity G-protein beta-subunit binding Cellular component plasma membrane

(restoring dark current). Low intracellular Ca2+ causes Ca2+ to dissociate from GTPase-activating protein (GAP), also known as regulator of G protein signaling

"Dock180–ELMO Cooperation in Rac Activation". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 388–402. doi:10

van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed

binding protein heterodimerization activity protein phosphatase binding GTPase activator activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Gene ontology Molecular function signal transducer activity GTPase activity G-protein beta-subunit binding Cellular component heterotrimeric G-protein

negative regulation of mitochondrial membrane permeability regulation of GTPase activity neuron projection morphogenesis regulation of cytoskeleton organization

can be activated by Rheb, a small, lysosomal-resident GTPase, in its GTP-bound state. Rheb GTPase activity is stimulated (and therefore capacity to activate

Gene ontology Molecular function protein kinase activity protein binding GTPase activator activity Cellular component GATOR1 complex lysosome lysosomal

"Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Molecular

Gene ontology Molecular function GTPase activator activity guanyl-nucleotide exchange factor activity Cellular component cytoplasm plasma membrane cytosol

Gene ontology Molecular function GTPase activator activity Cellular component autophagosome recycling endosome intracellular anatomical structure Biological

nucleotide binding GDP binding GTP binding myosin V binding protein binding GTPase activity Cellular component recycling endosome endosome late endosome rough

H. Batten Airport, Racine, Wisconsin, USA, IATA airport identifier Rac (GTPase), a subfamily of G proteins Recovery Audit Contractor, US program to find

Citi S (Oct 2008). "Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions". Molecular Biology

activity, RNA binding protein binding translation initiation factor activity GTPase activity cadherin binding Cellular component cytoplasm cytosol extracellular

Gene ontology Molecular function GTPase activator activity Cellular component cytosol membrane intrinsic component of the cytoplasmic side of the plasma

phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase". Nature Cell Biology. 3 (11): 1020–4. doi:10.1038/ncb1101-1020. PMID 11715024

Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200

protein that in humans is encoded by the RILP gene. RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]

GTP cyclohydrolase I activity mitogen-activated protein kinase binding GTPase activity GTP-dependent protein binding translation initiation factor binding

ARL4D Identifiers Aliases ARL4D, ARF4L, ARL6, ADP ribosylation factor like GTPase 4D External IDs OMIM: 600732; MGI: 1933155; HomoloGene: 1255; GeneCards:

"The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proceedings

compound neutrophil chemotaxis MAPK cascade chemotaxis positive regulation of GTPase activity positive regulation of calcium ion import macrophage chemotaxis

Gene ontology Molecular function PDZ domain binding protein binding GTPase activity signal transducer activity G-protein beta-subunit binding Cellular

protein binding AP-3 adaptor complex binding AP-1 adaptor complex binding GTPase activity Cellular component cytoplasm vesicle phagocytic vesicle membrane

elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19

process cellular response to ionizing radiation positive regulation of GTPase activity myoblast migration positive regulation of substrate adhesion-dependent

Gene ontology Molecular function GTPase activator activity frizzled binding protein kinase activator activity protein binding signaling receptor binding

doi:10.1242/jcs.042747. PMID 19509060. Lau AS, Mruk DD (April 2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10

Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences

proteolysis membrane protein ectodomain proteolysis positive regulation of GTPase activity cell-cell junction maintenance neutrophil extravasation phagocytosis

PMID 12543931. Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast

activation RhoGTPase activating protein is a protein that in humans is encoded by the TAGAP gene. This gene encodes a member of the Rho GTPase-activator protein

cross-linking motor proteins. The guanine nucleotide exchange factor for the small GTPase Ran (Regulator of chromosome condensation 1 or RCC1) is attached to nucleosomes

Carcinoma (TSCC) can be regulated via the expression of 2 key genes in Rho GTPase signaling pathway : RhoC and ROCK2 (Rho-associated protein kinase 2). Thus