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searching for Kinase 237 found (8065 total)

alternate case: kinase

Baricitinib (2,094 words) [view diff] exact match in snippet view article find links to article

tumor necrosis factor (TNF) inhibitors. It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved for medical
KIT (gene) (3,794 words) [view diff] exact match in snippet view article
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem
Imatinib (5,921 words) [view diff] exact match in snippet view article find links to article
result in harm to the baby. Imatinib works by stopping the Bcr-Abl tyrosine-kinase. This can slow growth or result in programmed cell death of certain types
CD135 (1,733 words) [view diff] exact match in snippet view article find links to article
also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans
Non-receptor tyrosine kinase (2,715 words) [view diff] exact match in snippet view article find links to article
A non-receptor tyrosine kinase (nRTK) is cytosolic enzyme that is responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate
HER2/neu (3,920 words) [view diff] exact match in snippet view article find links to article
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is
Tropomyosin receptor kinase A (3,264 words) [view diff] exact match in snippet view article find links to article
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming
RET proto-oncogene (2,301 words) [view diff] exact match in snippet view article find links to article
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular
MAPK/ERK pathway (3,139 words) [view diff] exact match in snippet view article find links to article
proteins, such as mitogen-activated protein kinases (MAPKs), originally called extracellular signal-regulated kinases (ERKs), which communicate by adding phosphate
TEK tyrosine kinase (1,689 words) [view diff] exact match in snippet view article find links to article
tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase.)
Kinase insert domain receptor (793 words) [view diff] exact match in snippet view article find links to article
Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF
Insulin receptor (3,723 words) [view diff] exact match in snippet view article find links to article
insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation
Fibroblast growth factor receptor 1 (5,055 words) [view diff] exact match in snippet view article find links to article
factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the
VEGF receptor (754 words) [view diff] exact match in snippet view article find links to article
of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and
Protein kinase inhibitor (788 words) [view diff] exact match in snippet view article find links to article
A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that add a
Bcr-Abl tyrosine-kinase inhibitor (6,354 words) [view diff] exact match in snippet view article find links to article
Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases
Dasatinib (1,945 words) [view diff] exact match in snippet view article find links to article
baby. It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family. Dasatinib was approved
Insulin-like growth factor 1 receptor (3,485 words) [view diff] exact match in snippet view article find links to article
related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide
MST1R (1,086 words) [view diff] exact match in snippet view article find links to article
d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase. MST1R has been shown
Janus kinase 2 (3,237 words) [view diff] exact match in snippet view article find links to article
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling
Nerve growth factor (2,007 words) [view diff] exact match in snippet view article find links to article
turn causes the autophosphorylation of the tyrosine kinase segment. The tropomyosin receptor kinase A receptor has five extracellular domains, and the
Fibroblast growth factor receptor 3 (1,865 words) [view diff] exact match in snippet view article find links to article
single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast
Osimertinib (1,204 words) [view diff] exact match in snippet view article find links to article
mutations. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor. The most common side effects include diarrhea, rash, musculoskeletal
Quizartinib (313 words) [view diff] exact match in snippet view article find links to article
Quizartinib (AC220) is a small molecule receptor tyrosine kinase inhibitor, originally from Ambit Biosciences and later acquired by Daiichi Sankyo, that
Fibroblast growth factor receptor 2 (1,837 words) [view diff] exact match in snippet view article find links to article
single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast
Growth factor receptor (583 words) [view diff] exact match in snippet view article find links to article
use the JAK/STAT, MAP kinase, and PI3 kinase pathways. A majority of growth factor receptors consists of receptor tyrosine kinases (RTKs). There are 3 dominant
Axitinib (1,039 words) [view diff] exact match in snippet view article find links to article
Axitinib, sold under the brand name Inlyta, is a small molecule tyrosine kinase inhibitor developed by Pfizer. It has been shown to significantly inhibit
Linsitinib (286 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
C-Met (6,841 words) [view diff] exact match in snippet view article find links to article
kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase
Fibroblast growth factor receptor 4 (1,288 words) [view diff] exact match in snippet view article find links to article
single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast
ATC code L01 (770 words) [view diff] no match in snippet view article find links to article
ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes
Fibroblast growth factor receptor (827 words) [view diff] exact match in snippet view article find links to article
single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factors, members of the
Fibroblast growth factor receptor 4 (1,288 words) [view diff] exact match in snippet view article find links to article
single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast
Proto-oncogene tyrosine-protein kinase Src (2,781 words) [view diff] exact match in snippet view article find links to article
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)
Janus kinase inhibitor (2,182 words) [view diff] exact match in snippet view article find links to article
Janus kinase inhibitors, also known as JAK inhibitors or jakinibs, are a type of medication that functions by inhibiting the activity of one or more of
Discoidin domain-containing receptor 2 (1,397 words) [view diff] exact match in snippet view article find links to article
DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK). RTKs play a key role in the communication of cells with their microenvironment
DDR1 (1,204 words) [view diff] exact match in snippet view article find links to article
(cluster of differentiation 167a), is a human gene. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment
ERBB3 (2,748 words) [view diff] exact match in snippet view article find links to article
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded
Semaxanib (400 words) [view diff] exact match in snippet view article find links to article
Semaxanib (SU5416) is a tyrosine-kinase inhibitor drug designed by SUGEN as a cancer therapeutic. It is an experimental stage drug, not licensed for use
Proto-oncogene tyrosine-protein kinase Src (2,781 words) [view diff] exact match in snippet view article find links to article
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)
Discoidin domain-containing receptor 2 (1,397 words) [view diff] exact match in snippet view article find links to article
DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK). RTKs play a key role in the communication of cells with their microenvironment
Semaxanib (400 words) [view diff] exact match in snippet view article find links to article
Semaxanib (SU5416) is a tyrosine-kinase inhibitor drug designed by SUGEN as a cancer therapeutic. It is an experimental stage drug, not licensed for use
Masitinib (706 words) [view diff] exact match in snippet view article find links to article
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumours in animals, specifically dogs. Since its introduction in November 2008
Tyrosine kinase inhibitor (1,073 words) [view diff] exact match in snippet view article find links to article
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation
ABL (gene) (3,466 words) [view diff] exact match in snippet view article
Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9
Vandetanib (1,149 words) [view diff] exact match in snippet view article find links to article
for the treatment of certain tumours of the thyroid gland. It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial
Glycolysis (8,153 words) [view diff] exact match in snippet view article find links to article
pyruvate kinase is indirectly regulated by epinephrine and glucagon, through protein kinase A. This protein kinase phosphorylates liver pyruvate kinase to deactivate
Tyrosine kinase inhibitor (1,073 words) [view diff] exact match in snippet view article find links to article
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation
Erlotinib (1,815 words) [view diff] exact match in snippet view article find links to article
ulceration. Use in pregnancy may harm the baby. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). Erlotinib
Lenvatinib (887 words) [view diff] exact match in snippet view article find links to article
developed by Eisai Co. and acts as a multiple kinase inhibitor against the VEGFR1, VEGFR2 and VEGFR3 kinases. Lenvatinib is approved (since 2015) for the
Erythropoietin (3,092 words) [view diff] exact match in snippet view article find links to article
kinase activity embryo implantation signal transduction positive regulation of activated T cell proliferation positive regulation of protein kinase activity
ATF1 (1,365 words) [view diff] exact match in snippet view article find links to article
serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen-
Colony-stimulating factor (329 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Radotinib (302 words) [view diff] exact match in snippet view article find links to article
leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such as patients resistant or intolerant to imatinib. Radotinib
Gefitinib (1,961 words) [view diff] exact match in snippet view article find links to article
tyrosine kinase domain is responsible for activating anti-apoptotic pathways. These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors
Entrectinib (2,029 words) [view diff] exact match in snippet view article find links to article
tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK). The
Cyclic adenosine monophosphate (1,249 words) [view diff] exact match in snippet view article find links to article
It should not be confused with 5'-AMP-activated protein kinase (AMP-activated protein kinase). Earl Sutherland of Vanderbilt University won a Nobel Prize
Regorafenib (826 words) [view diff] exact match in snippet view article find links to article
others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows
Infigratinib (255 words) [view diff] exact match in snippet view article find links to article
used to treat cholangiocarcinoma (bile duct cancer). Infigratinib is a kinase inhibitor targeting the fibroblast growth factor receptors FGFR1, FGFR2
Pazopanib (1,274 words) [view diff] exact match in snippet view article find links to article
Novartis. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. It has been
Toceranib (281 words) [view diff] exact match in snippet view article find links to article
Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. Together with masitinib
PDGFRB (3,400 words) [view diff] exact match in snippet view article find links to article
PDGFRB gene encodes a typical receptor tyrosine kinase, which belongs to the type III tyrosine kinase receptor (RTK) family and is structurally characterized
AURKC (2,008 words) [view diff] exact match in snippet view article find links to article
Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene. This gene encodes a member of the highly conserved Aurora
Philadelphia chromosome (3,446 words) [view diff] exact match in snippet view article find links to article
region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signalling protein that is "always on", causing the cell to divide uncontrollably
Janus kinase 1 (2,341 words) [view diff] exact match in snippet view article find links to article
JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc)
FGF6 (595 words) [view diff] exact match in snippet view article find links to article
activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity Cellular component
ERBB4 (1,663 words) [view diff] exact match in snippet view article find links to article
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different
Grandinin (359 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Icotinib (666 words) [view diff] exact match in snippet view article find links to article
highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Icotinib is approved for use in China as first-line
Janus kinase 3 (4,854 words) [view diff] exact match in snippet view article find links to article
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene. Janus kinase 3 is a tyrosine kinase that belongs to
Cediranib (642 words) [view diff] exact match in snippet view article find links to article
inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. The drug is being developed by AstraZeneca as a possible anti-cancer chemotherapeutic
Icrucumab (139 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
PDGFB (425 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Angiopoietin receptor (223 words) [view diff] exact match in snippet view article find links to article
their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation
Thrombopoietin (1,064 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Mubritinib (141 words) [view diff] exact match in snippet view article find links to article
Mubritinib (TAK-165) is a protein kinase inhibitor which was under development by Takeda for the treatment of cancer. It completed phase I clinical trials
Tivozanib (962 words) [view diff] exact match in snippet view article find links to article
advanced renal cell carcinoma (RCC). It is an oral VEGF receptor tyrosine kinase inhibitor. The most common side effects include fatigue, hypertension, diarrhea
Selpercatinib (1,234 words) [view diff] exact match in snippet view article find links to article
rash, and constipation. Selpercatinib is a kinase inhibitor, meaning it blocks a type of enzyme (kinase) and helps prevent the cancer cells from growing
Epidermal growth factor (1,672 words) [view diff] exact match in snippet view article find links to article
activating the intrinsic protein-tyrosine kinase activity of the receptor (see the second diagram). The tyrosine kinase activity, in turn, initiates a signal
Trastuzumab deruxtecan (1,166 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Afatinib (1,117 words) [view diff] exact match in snippet view article find links to article
treat non-small cell lung carcinoma (NSCLC). It belongs to the tyrosine kinase inhibitor family of medications. It is taken by mouth. It is mainly used
Sunitinib (3,024 words) [view diff] exact match in snippet view article find links to article
treat cancer. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal
Nilotinib (1,675 words) [view diff] exact match in snippet view article find links to article
It is not safe for use during pregnancy. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell
Thrombopoietin receptor (1,525 words) [view diff] exact match in snippet view article find links to article
thrombopoietin, CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and
Zalutumumab (794 words) [view diff] exact match in snippet view article find links to article
tyrosine kinase. Its structure includes an extracellular binding domain, a transmembrane lipophilic segment, and an intracellular tyrosine kinase domain
Cabozantinib (1,672 words) [view diff] exact match in snippet view article find links to article
hepatocellular carcinoma. It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. It was discovered and
PDK4 (2,519 words) [view diff] exact match in snippet view article find links to article
lipoamide kinase isozyme 4, mitochondrial is an enzyme that in humans is encoded by the PDK4 gene. It codes for an isozyme of pyruvate dehydrogenase kinase. This
Growth factor (1,112 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Colony stimulating factor 1 receptor (2,030 words) [view diff] exact match in snippet view article find links to article
encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Increased levels of CSF1R1
Brigatinib (657 words) [view diff] exact match in snippet view article find links to article
ARIAD Pharmaceuticals, Inc. Brigatinib acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor. Brigatinib
Cyclin-dependent kinase inhibitor protein (201 words) [view diff] exact match in snippet view article find links to article
A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several function as tumor suppressor
Ephrin B1 (1,094 words) [view diff] exact match in snippet view article find links to article
type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or
Necitumumab (161 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Neratinib (1,185 words) [view diff] exact match in snippet view article find links to article
Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the treatment of breast cancer. The
Somatomedin receptor (59 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
ELK1 (2,459 words) [view diff] exact match in snippet view article find links to article
Figure 2, Raf kinase acts upstream of MAPKs to activate them by phosphorylating and, thereby activating, MEKs, or MAPK or ERK kinases. Raf itself is
Ganitumab (128 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Emibetuzumab (117 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Gossypetin (184 words) [view diff] exact match in snippet view article find links to article
4'-pentahydroxy-8-methoxyflavone.[citation needed] Tropomyosin receptor kinase B § Antagonists Antibacterial activity of gossypetin isolated from hibiscus
ELK1 (2,459 words) [view diff] exact match in snippet view article find links to article
Figure 2, Raf kinase acts upstream of MAPKs to activate them by phosphorylating and, thereby activating, MEKs, or MAPK or ERK kinases. Raf itself is
Ganitumab (128 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Flanvotumab (59 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Neuregulin 4 (410 words) [view diff] exact match in snippet view article find links to article
gene. The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation
PTK2B (1,876 words) [view diff] exact match in snippet view article find links to article
Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene. This gene encodes a cytoplasmic protein tyrosine kinase that is involved
ErbB (2,625 words) [view diff] exact match in snippet view article find links to article
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered
Nesvacumab (127 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Futuximab (127 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Tovetumab (148 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Imgatuzumab (124 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Neurotrophin-3 (1,648 words) [view diff] exact match in snippet view article find links to article
potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB – see below). Mice born without the
Dalotuzumab (40 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Smooth muscle (4,398 words) [view diff] exact match in snippet view article find links to article
phospholipase C), G proteins (RhoA, G alpha), kinases (rho kinase-ROCK, protein kinase C, protein Kinase A), ion channels (L type calcium channels, ATP
Ciliary neurotrophic factor receptor (477 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Avapritinib (1,034 words) [view diff] exact match in snippet view article find links to article
tears), abdominal pain, constipation, rash and dizziness. Avapritinib is a kinase inhibitor. Avapritinib is indicated for the treatment of adults with unresectable
Canertinib (241 words) [view diff] exact match in snippet view article find links to article
drug candidate for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and
Midostaurin (566 words) [view diff] exact match in snippet view article find links to article
brand name Rydapt & Tauritmo both by Novartis, is a multi-targeted protein kinase inhibitor that has been investigated for the treatment of acute myeloid
Capmatinib (950 words) [view diff] exact match in snippet view article find links to article
mesenchymal-epithelial transition or MET exon 14 skipping). Capmatinib is a kinase inhibitor indicated for the treatment of adults with metastatic non-small
CAMK1D (167 words) [view diff] exact match in snippet view article find links to article
Calcium/calmodulin-dependent protein kinase ID is a protein in humans that is encoded by the CAMK1D gene on chromosome 10 (locus 10p13). This gene encodes
Duligotuzumab (84 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Robatumumab (178 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Dusigitumab (89 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Patritumab (160 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Insulin-like growth factor 2 (1,586 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Ripretinib (1,136 words) [view diff] exact match in snippet view article find links to article
gastrointestinal tract. It is taken by mouth. Ripretinib inhibits the activity of the kinases KIT and PDGFRA, which helps keep cancer cells from growing. The most common
Fasudil (1,176 words) [view diff] exact match in snippet view article find links to article
Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which
Mecasermin (260 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Ancestim (278 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
FGF15/19 (249 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Matuzumab (842 words) [view diff] exact match in snippet view article find links to article
of the extracellular domain of the EGFR. The EGFR is receptor tyrosine kinase which binds multiple growth factors including EGF (epidermal growth factor)
Rilotumumab (127 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Tanezumab (519 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
PDGFA (1,076 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Epigen (200 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Keratinocyte growth factor (180 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Pacritinib (168 words) [view diff] exact match in snippet view article find links to article
Janus kinase inhibitor that is being developed for the treatment of myelofibrosis. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3
Tucatinib (1,447 words) [view diff] exact match in snippet view article find links to article
August 2020, and in the European Union in February 2021. Tucatinib is a kinase inhibitor indicated in combination with trastuzumab and capecitabine for
Phosphoinositide 3-kinase inhibitor (2,856 words) [view diff] exact match in snippet view article find links to article
phosphoinositide 3-kinase inhibitor (PI3K inhibitor) is a class of medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes
Diosmetin (133 words) [view diff] exact match in snippet view article find links to article
receptor agonist. Diosmetin is the aglycone of diosmin. Tropomyosin receptor kinase B § Agonists Diosmetin glycosides from caucasian vetch: Isolation and study
N-Acetylserotonin (1,142 words) [view diff] exact match in snippet view article find links to article
penetrate the blood–brain barrier, unlike serotonin. Tropomyosin receptor kinase B § Agonists AXELROD J, WEISSBACH H (April 1960). "Enzymatic O-methylation
Onartuzumab (424 words) [view diff] exact match in snippet view article find links to article
Fab fragment Source Humanized (from mouse) Target scatter factor receptor kinase Clinical data ATC code none Identifiers CAS Number 1133766-06-9 N ChemSpider
Figitumumab (298 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Pituitary adenylate cyclase-activating peptide (1,625 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Stem cell factor (2,941 words) [view diff] exact match in snippet view article find links to article
soluble SCF. SCF binds to the c-KIT receptor (CD 117), a receptor tyrosine kinase. c-Kit is expressed in HSCs, mast cells, melanocytes, and germ cells. It
ZAP70 (2,714 words) [view diff] exact match in snippet view article find links to article
ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells
Pacritinib (168 words) [view diff] exact match in snippet view article find links to article
Janus kinase inhibitor that is being developed for the treatment of myelofibrosis. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3
Neurotrophin-4 (946 words) [view diff] exact match in snippet view article find links to article
signals predominantly through the TrkB receptor tyrosine kinase. Tropomyosin receptor kinase B § Agonists GRCh38: Ensembl release 89: ENSG00000225950
Receptor for activated C kinase 1 (2,586 words) [view diff] exact match in snippet view article find links to article
Receptor for activated C kinase 1 (RACK1), also known as guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), is a 35 kDa protein that in
FGF15/19 (249 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Fasinumab (101 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Nicotinamide adenine dinucleotide phosphate (1,496 words) [view diff] exact match in snippet view article find links to article
that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase. In general, NADP+ is synthesized before
Tropoflavin (2,217 words) [view diff] exact match in snippet view article find links to article
potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin
Angiopoietin 1 (1,621 words) [view diff] exact match in snippet view article find links to article
with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that
Vascular endothelial growth factor (4,364 words) [view diff] exact match in snippet view article find links to article
later at 1.9 Å. Fms-like tyrosine kinase-1 (flt-1) was shown to be a VEGF receptor by Ferrara et al. in 1992. The kinase insert domain receptor (KDR) was
Insulin-like growth factor-binding protein (467 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Ficlatuzumab (87 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
FGF3 (782 words) [view diff] exact match in snippet view article find links to article
activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein tyrosine kinase activity Cellular component
Norwogonin (174 words) [view diff] exact match in snippet view article find links to article
related but more well-known tropoflavin (7,8-DHF). Tropomyosin receptor kinase B § Agonists Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell
Ancestim (278 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Glia maturation factor (106 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Stem cell factor (2,941 words) [view diff] exact match in snippet view article find links to article
soluble SCF. SCF binds to the c-KIT receptor (CD 117), a receptor tyrosine kinase. c-Kit is expressed in HSCs, mast cells, melanocytes, and germ cells. It
Persephin (386 words) [view diff] exact match in snippet view article find links to article
family of ligands, persephin uses a receptor that consists of the tyrosine kinase signaling component Ret and a unit of glycosylphosphatidylinsitol (GPI)-anchored
Adrenomedullin (1,428 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Neuregulin 2 (707 words) [view diff] exact match in snippet view article find links to article
(May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115. S2CID 4310136
TGF beta receptor 2 (934 words) [view diff] exact match in snippet view article find links to article
serine/threonine protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a
PDGFA (1,076 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
IGFBP2 (875 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Ruxolitinib (1,399 words) [view diff] exact match in snippet view article find links to article
elsewhere in the world, under the brand name Jakavi. Ruxolitinib is a janus kinase inhibitor. In September 2021, ruxolitinib cream (sold under the brand name
Cixutumumab (615 words) [view diff] exact match in snippet view article find links to article
may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types
FGF7 (1,228 words) [view diff] exact match in snippet view article find links to article
activity 1-phosphatidylinositol-3-kinase activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component
Alacizumab pegol (35 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
FGF20 (221 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
FGF22 (203 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Crenolanib (2,038 words) [view diff] exact match in snippet view article find links to article
wild-type and mutant isoforms of class III receptor tyrosine kinases (RTK) FLT3 (FMS-like Tyrosine Kinase 3), PDGFR α (Platelet-Derived Growth Factor Receptor)
R13 (drug) (257 words) [view diff] exact match in snippet view article
orally active, potent, and selective agonist of the tropomyosin receptor kinase B (TrkB) – the main signaling receptor for the neurotrophin brain-derived
7,8,3'-Trihydroxyflavone (249 words) [view diff] exact match in snippet view article find links to article
neuroprotective effects in mice similarly to tropoflavin. Tropomyosin receptor kinase B § Agonists Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al
FGF17 (642 words) [view diff] exact match in snippet view article find links to article
activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity Cellular component
Savolitinib (68 words) [view diff] no match in snippet view article find links to article
Savolitinib is an experimental small molecule inhibitor of c-Met. It is being investigated for the treatment of cancer by AstraZeneca. It is in phase II
Ramucirumab (1,259 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Fibroblast growth factor 23 (1,480 words) [view diff] exact match in snippet view article find links to article
renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 277 (31): 28265–70. doi:10
Cenegermin (250 words) [view diff] exact match in snippet view article find links to article
eyes, retinitis pigmentosa, and glaucoma. Tavilermide Tropomyosin receptor kinase A World Health Organization (2017). "International nonproprietary names
PDGFD (790 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
HIOC (369 words) [view diff] exact match in snippet view article find links to article
long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor. HIOC is systemically-active and is able to
Olaratumab (896 words) [view diff] exact match in snippet view article find links to article
alpha of the platelet-derived growth factor receptor, a type of tyrosine kinase. After intravenous infusion, olaratumab has a volume of distribution of
IGFBP5 (882 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Momelotinib (328 words) [view diff] exact match in snippet view article find links to article
Momelotinib (INN, formerly GS-0387, CYT-387) is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18
RTK class III (66 words) [view diff] exact match in snippet view article find links to article
RTK class III is a class of receptor tyrosine kinases. It includes PDGFRα, PDGFRβ, C-KIT, CSF1R, and FLT3. Abu-Duhier FM, Goodeve AC, Care RS, et al.
Trafermin (301 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
ADCYAP1R1 (1,550 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Basic fibroblast growth factor (2,267 words) [view diff] exact match in snippet view article find links to article
to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase. FGF2 has been shown in preliminary animal studies to protect the heart
Panitumumab (1,248 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
LYN (3,767 words) [view diff] exact match in snippet view article find links to article
Tyrosine-protein kinase Lyn is a protein that in humans is encoded by the LYN gene. Lyn is a member of the Src family of protein tyrosine kinases, which is mainly
Insulin-like growth factor 2 receptor (1,661 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
R13 (drug) (257 words) [view diff] exact match in snippet view article
orally active, potent, and selective agonist of the tropomyosin receptor kinase B (TrkB) – the main signaling receptor for the neurotrophin brain-derived
PDGFD (790 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Pyruvate kinase deficiency (1,474 words) [view diff] exact match in snippet view article find links to article
Pyruvate kinase deficiency is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells. Both autosomal
VEGFR1 (1,093 words) [view diff] exact match in snippet view article find links to article
(MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation
Nicorandil (939 words) [view diff] exact match in snippet view article find links to article
involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to increased
Motesanib (946 words) [view diff] exact match in snippet view article find links to article
by Rongshi Li, Jeffrey A. (2009). "Chapter 5. Discovery of Motesanib". Kinase inhibitor drugs. Hoboken, N.J.: Wiley. pp. 113–130. doi:10.1002/9780470524961
HIOC (369 words) [view diff] exact match in snippet view article find links to article
long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor. HIOC is systemically-active and is able to
Momelotinib (328 words) [view diff] exact match in snippet view article find links to article
Momelotinib (INN, formerly GS-0387, CYT-387) is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18
GFRA3 (604 words) [view diff] exact match in snippet view article find links to article
receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRα GRCh38: Ensembl release 89:
FGF18 (1,078 words) [view diff] exact match in snippet view article find links to article
activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity Cellular component
Panitumumab (1,248 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Cetuximab (2,006 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Tyrosine-protein kinase SYK (2,073 words) [view diff] exact match in snippet view article find links to article
Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK, along with ZAP70, is a
Nintedanib (2,687 words) [view diff] exact match in snippet view article find links to article
abdominal pain, vomiting, and diarrhea. It is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor, fibroblast
CSPG5 (456 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Becaplermin (432 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
GFRA2 (gene) (820 words) [view diff] exact match in snippet view article
the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN
TGF beta receptor 1 (1,487 words) [view diff] exact match in snippet view article find links to article
Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor
Evinacumab (559 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Ephrin A5 (1,204 words) [view diff] exact match in snippet view article find links to article
encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17". Genomics
Mecasermin rinfabate (1,225 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
T-cell growth factor (216 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
Leukocyte receptor tyrosine kinase (849 words) [view diff] exact match in snippet view article find links to article
Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene. The protein encoded by this gene is a member of the ALK/LTK
Platelet-derived growth factor (2,879 words) [view diff] exact match in snippet view article find links to article
PDGFA and PDGFB heterodimer). The ligands interact with the two tyrosine kinase receptor monomers, PDGFRα (PDGFRA) and -Rβ (PDGFRB). The PDGF family also
GFRA4 (80 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
C-fos-induced growth factor (1,234 words) [view diff] exact match in snippet view article find links to article
"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the
Ephrin A4 (655 words) [view diff] exact match in snippet view article find links to article
receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially
Dacomitinib (266 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
GTF2H1 (1,530 words) [view diff] exact match in snippet view article find links to article
the GTF2H1 gene. GTF2H1 has been shown to interact with: Cyclin-dependent kinase 7, E2F1, ERCC2, Estrogen receptor alpha, TCEA1, and XPB. Transcription Factor
Tavilermide (390 words) [view diff] exact match in snippet view article find links to article
Liatermin Kinase inhibitors: Vandetanib GFRα2 Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib GFRα3 Agonists: Artemin (ARTN) Kinase inhibitors:
ROR2 (1,121 words) [view diff] exact match in snippet view article find links to article
Tyrosine-protein kinase transmembrane receptor ROR2 also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded
ANGPT2 (1,113 words) [view diff] exact match in snippet view article find links to article
Angiopoietin#Clinical relevance ANGPT2 has been shown to interact with TEK tyrosine kinase. Angiopoietin GRCh38: Ensembl release 89: ENSG00000091879 - Ensembl, May
Ephrin B2 (1,306 words) [view diff] exact match in snippet view article find links to article
receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially
Ephrin A2 (671 words) [view diff] exact match in snippet view article find links to article
receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly
FGF5 (2,274 words) [view diff] exact match in snippet view article find links to article
and invasion. FGF proteins interact with a family of specific tyrosine kinase receptors, a process often regulated by proteoglycans or extracellular binding
Abrocitinib (703 words) [view diff] exact match in snippet view article find links to article
Abrocitinib, sold under the brand name Cibinqo, is a Janus kinase inhibitor medication used for the treatment of atopic dermatitis (eczema). It was developed
Eutropoflavin (324 words) [view diff] exact match in snippet view article find links to article
neurogenic, and antidepressant-like effects in animals. Tropomyosin receptor kinase B § Agonists Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al
ETV6 (4,615 words) [view diff] exact match in snippet view article find links to article
gene fusion to receptor tyrosine kinases and non-receptor tyrosine kinases may be sensitive to therapy with tyrosine kinase inhibitors. For example, patients
Nimotuzumab (803 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
Cyclotraxin B (301 words) [view diff] exact match in snippet view article find links to article
receptors of vascular endothelial growth factor (VEGF). Tropomyosin receptor kinase B § Antagonists Cazorla M, Jouvenceau A, Rose C, Guilloux JP, Pilon C, Dranovsky
Teprotumumab (925 words) [view diff] exact match in snippet view article find links to article
Angiopoietin 1 Angiopoietin 4 Antagonists: Angiopoietin 2 Angiopoietin 3 Kinase inhibitors: Altiratinib CE-245677 Rebastinib Antibodies: Evinacumab (against
MST1 (898 words) [view diff] exact match in snippet view article find links to article
PMID 8621550. Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain". J. Biol. Chem. 271
Insulin-like growth factor 1 (3,603 words) [view diff] exact match in snippet view article find links to article
synthesis. IGF-1 binds to at least two cell surface receptor tyrosine kinases: the IGF-1 receptor (IGF1R), and the insulin receptor. Its primary action
Enzyme-linked receptor (352 words) [view diff] exact match in snippet view article find links to article
tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme-linked receptors are of this type. Serine/threonine-specific protein kinase, as in
Ephrin A1 (1,161 words) [view diff] exact match in snippet view article find links to article
receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially