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searching for folate 109 found (1252 total)

alternate case: Folate

Glutamate carboxypeptidase II (4,300 words) [view diff] exact match in snippet view article find links to article

membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately

organisms require reduced folate cofactors for the synthesis of a variety of metabolites. Most microorganisms must synthesize folate de novo because they lack

against folate receptor alpha have been found in up to 75% of children with autism. Folate deficiency most commonly arises from insufficient folate intake

tube cancer, or primary peritoneal cancer. Mirvetuximab soravtansine is a folate receptor alpha directed antibody and microtubule inhibitor conjugate. The

It is decreased with methyl folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate, and a decrease in formiminoglutamic

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Early prostate cancer causes

most often due to hypovitaminosis, specifically vitamin B12 deficiency or folate deficiency. Loss of micronutrients may also be a cause. Megaloblastic anemia

intermediate interferes with the normal bacterial synthesis of folic acid (folate). Folate is an essential metabolite for bacterial growth and replication because

1186/s12976-016-0037-2 Björklund, NK, Gordon, R A hypothesis linking low folate intake to neural tube defects due to failure of post-translation methylations

Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member

A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance

for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate

function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be

polyglutamates and glutamate. Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase

ovarian cancer. This drug was developed by Morphotek, Inc. It is targeted at folate receptor alpha (FRα) which is overexpressed in some cancers such as epithelial

However, because the folates used by folate metabolic and folate-dependent enzymes are all very similar in structure and folate mimics are already common

beta-lactam-betalactamase inhibitor combinations (such as piperacillin-tazobactam), folate antagonists, quinolones, and carbapenems. Many of these antibiotics also

"Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate

cerebral folate deficiency in the Kearns–Sayre syndrome is the failure of the mechanisms in the choroid plexus that are responsible for passage of folates from

the intestinal flora. These bacteria are also responsible for producing folate and vitamin B12 in nukazuke. Further, since nukazuke absorb nutrients from

cerebral folate deficiency in the Kearns–Sayre syndrome is the failure of the mechanisms in the choroid plexus that are responsible for passage of folates from

lies. The cleft consists of the GAR binding site and the folate-binding pocket. The folate-binding pocket is delineated by pteridine-binding cleft, the

in folate levels or folate metabolism could significantly impact DNA methylation and contribute to what causes autism. This idea is what makes folate pathways

known as folate receptor 4, folate receptor delta or IZUMO1R is a protein that in humans is encoded by the FOLR4 gene. Juno is a member of the folate receptor

reactions, and bone marrow suppression. It should not be used by people with folate deficiency that has resulted in anemia. There is concern that it may increase

Pantothenic acid 1.48 mg Vitamin B-6 0.594 mg Folate, total 29.7 µg Folic acid 0 µg Folate, food 29.7 µg Folate, DFE 29.7 µg Choline, total 129 mg Vitamin

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folate receptor (FOLR)

cancerous cells take in natural folate through a protein identified as plasma membrane transporter (now referred to as "reduced folate carrier type 1" or "RFC-1")

abnormalities of folate metabolism in ASD. These abnormalities can lead to a decrease in 5-methyltetrahydrofolate production, alter the production of folate metabolites

beverage is high in protein, vitamins, calcium, magnesium, molybdenum, folate, and selenium, and is a dieter's drink, as it is quite filling but low in

vitamin, folate (folic acid), to a molecule/drug to form a "folate conjugate". Based on the natural high affinity of folate for the folate receptor protein

Dyskeratosis congenita Myelodysplastic syndrome Leukemia Leishmaniasis Severe folate or vitamin B12 deficiency Systemic lupus erythematosus Paroxysmal nocturnal

945/ ONX-0801 OSI-7904L CB300638 Jackman AL, Calvert AH (November 1995). "Folate-based thymidylate synthase inhibitors as anticancer drugs". Annals of Oncology

Concentrations of blood plasma folate and homocysteine concentrations are inversely related, such that an increase in dietary folate decreases homocysteine concentration

methionine synthase (MTR). The folate cycle is linked to homocysteine metabolism via MTR. Circulating blood folate (5-methyl tetrahydrofolate, 5-MTHF)

used in DNA methylation are often derived from dietary sources, such as folate and choline, and explains why diet can have a significant impact on methylation

antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide

also been reported. Patients with mild phenotypes may deteriorate if given folate antagonists such as methotrexate, which can interfere with a salvage pathway

Folate receptor gamma is a protein that in humans is encoded by the FOLR3 gene. It is involved in up-take of folic acid. The FOLR multi-gene family (FOLR1

disease Dietary deficiencies: Folate deficiency and vitamin B12 deficiency are common causes of anemia in pregnancy. Folate deficiency occurs due to diets

Calmodulin-binding proteins Iron-binding proteins Thyroxine-binding proteins Folate-binding protein Sterol regulatory element-binding protein GTP-binding protein

precursor for the production of folates. Folates are family of cofactors that are essential for living organisms. Folate cofactors are used in several one-carbon

class of chemotherapy drugs called folate antimetabolites, which inhibit one or more of three enzymes that use folate and derivatives as substrates: DHFR

6-pyruvoyltetrahydropterin synthase, also known as PTS, is a human gene which facilitates folate biosynthesis. 6-pyruvoyltetrahydropterin synthase 6-Pyruvoyltetrahydropterin

treating refractive error. Its nutrition programs include vitamin A, iron/folate, and multi-micronutrient supplementation, fortification of commonly used

caused by mutations of the SLC25A32 gene that encodes the mitochondrial folate transporter. Patients suffer from exercise intolerance and may have disrupted

Use of this drug is contraindicated in: Megaloblastic anaemia caused by folate deficiency Hypersensitivity to pyrimethamine, sulfonamides, or any ingredient

caused by mutations of the SLC25A32 gene that encodes the mitochondrial folate transporter. Patients suffer from exercise intolerance and may have disrupted

metabolism-related pathway involved in the generation of NADPH is the mitochondrial folate cycle, which uses principally serine as a source of one-carbon units to

small molecule drug conjugate consisting of a small molecule targeting the folate receptor, which is expressed on many cancers, such as ovarian cancer, and

liver by Kerr. In 1984, Cook and Wagner demonstrated that a liver cytosolic folate binding protein is identical to GNMT. The human GMNT gene was cloned in

reproduced in full below: "A method for detecting a deficiency of cobalamin or folate in warm-blooded animals comprising the steps of: "assaying a body fluid

produce three B vitamin types, biotin (vitamin B7), riboflavin (B2) and folate (B9). Francisella endosymbionts are often misidentified as Francisella tularensis;

reproduced in full below: "A method for detecting a deficiency of cobalamin or folate in warm-blooded animals comprising the steps of: "assaying a body fluid

experimental drug that has been developed to target ovarian cancer. It is a folate receptor alpha mediated thymidylate synthase inhibitor. ONX-0801 was originally

produce three B vitamin types, biotin (vitamin B7), riboflavin (B2) and folate (B9). Francisella endosymbionts are often misidentified as Francisella tularensis;

The folate-biopterin transporter (FBT) family (TC# 2.A.71) is a distant family within the major facilitator superfamily, most closely related to drug resistance

Hartge P, et al. (2007). "Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER

amounts of studies and participants, more clinical studies are needed. Folate in combination with zinc supplementation was shown to have a statistically

reductase deficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder is inherited

6-pyruvoyl-tetrahydropterin synthase, dihydropteridine reductase, sepiapterin reductase, folate receptor alpha, dihydrofolate reductase, 3-phosphoglycerate dehydrogenase

Reduced Folate Carrier (RFC) Family (TC# 2.A.48) is a group of transport proteins that is part of the major facilitator superfamily. RFCs take up folate, reduced

2013. He is known for his contributions to the field of inborn errors of folate and vitamin B12 metabolism. Rosenblatt received a Bachelor of Science from

reductase deficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder is inherited

University of Toronto. Her thesis was "The effect of folate supplementation on folate status and breastmilk folate concentration in lactating women". Houghton

University of Toronto. Her thesis was "The effect of folate supplementation on folate status and breastmilk folate concentration in lactating women". Houghton

slightly higher chance that females will develop the condition over males. Folate deficiency is also a well-accepted risk factor of all neural tube defects

PMID 28331572. Rossignol DA, Frye RE (November 2021). "Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment

Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV infection, and certain medications (e.g

liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity. As a thymidylate synthase inhibitor

fluorescence-guided surgery. Pafolacianine is a fluorescent medication that binds to folate receptor (FR)-expressing cells. The most common side effects of pafolacianine

of endothelial NO synthase enzyme might be potentially elevated by folate, folate supplementation might be capable of restoring the availability of NO

Congenital dyserythropoietic anemia Malnutrition - (e.g. deficiencies in B12, folate, iron) Sequelae of malignancy, connective tissue disease, autoimmune disease

This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have

have developed dark skin to block out the sun and protect their body's folate reserves. Those living away from the equator have developed light skin to

molecules to release active folate, without which a functional folate deficiency occurs [5]. Folate is required for the folate cycle, so deficiency prompts

Another paper presented there focused on the prevalence of autoantibodies to folate receptors in autistic children, and found that about 75% of children with

the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised during

Peyronnard JM, Bachevalier J, Charron L (September 1978). "Polyneuropathy and folate deficiency". Archives of Neurology. 35 (9): 581–4. doi:10.1001/archneur

epigenetics. Sources of methyl groups include S-methylmethionine, methyl folate, methyl B12. Methanogenesis, the process that generates methane from CO2

that DIP2B may participate in DNA methylation. This gene is located near a folate-sensitive fragile site. GRCh38: Ensembl release 89: ENSG00000066084 – Ensembl

been shown to affect the expression of folate receptor alpha, and CIC mutations might result in cerebral folate deficiency. ATXN1 — capicua and ataxin

Thrombocytopenia in hospitalized alcoholics may be caused by spleen enlargement, folate deficiency, and most frequently, the direct toxic effect of alcohol on production

that DIP2B may participate in DNA methylation. This gene is located near a folate-sensitive fragile site. GRCh38: Ensembl release 89: ENSG00000066084 – Ensembl

been shown to affect the expression of folate receptor alpha, and CIC mutations might result in cerebral folate deficiency. ATXN1 — capicua and ataxin

Wojcicki P, Dziegelewska M, Jagodzinski PP (Dec 2010). "Associations of folate and choline metabolism gene polymorphisms with orofacial clefts". Journal

Y., Toriumi, N., Sarashina, T. et al. An infantile case of hereditary folate malabsorption with sudden development of pulmonary hemorrhage: a case report

in depression from 1970, and consistently found low plasma and red cell folate in patients with severe depression. He also showed that a folic acid supplement

Low dietary intake Infection with Giardia Celiac sprue Dilantin Relative folate deficiency Old Pregnant ABCD: Anderson's = Branching enzyme Cori's = Debranching

FC, Smith AD, Martin RM (Nov 2010). "Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen

sweet taste and are very aromatic. Red raspberries contains 31 μg/100 g of folate. Red raspberries have antioxidant effects that play a minor role in the

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.[citation needed] Sulfadoxine/pyrimethamine Scholia has a topic

out folate deficiency as a major risk factor for neural tube defects. FB1 disrupts sphingolipid metabolism and therefore this could affect folate uptake

JS, Kaplan BS, Nunez LD, et al. (September 2011). "Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations

disease and cancer. They are also a great source of vitamin C, potassium, folate and vitamin K. Contains fiber, vitamin E and C. North Africans use it to

uses Folate Receptors (FR) to detect tumor lesions as small as 370 micrometers. Folate Receptors are membrane bound surface proteins that bind folates and

compounds play in fetal development. The increased dosage of folic acid or folates reflects the American Dietetic Associations position that women should

is currently in a Phase I clinical trial. STRO-002 is an ADC targeting folate receptor alpha, a cell-surface protein highly expressed in gynecological

PMID 27422195. Singh P, Gupta U, Asthana A, Jain NK (November 2008). "Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer

zinc, vitamin E, iron, calcium, and other quantities of zinc, vitamin A, folate, and other minerals that support proper organ function. Dasheri mangoes

known to be a causal factor in the development of peripheral neuropathy. Folate is present in food in a polyglutamate form, which is then converted into

Invest. 56 (5): 1125–1131. doi:10.1172/JCI108187. PMC 301974. PMID 1184739. "Folate-deficiency anemia". National Center for Biotechnology Information. U.S.

subsequently metabolized to formate, which is in turn metabolized by a folate dependent mechanism. Side effects are similar to intravenous phenytoin and

S. J., and Wright, P. E. (1995) Dynamics of the dihydrofolate reductase—folate complex: Catalytic sites and regions known to undergo conformational change

medications and other environmental causes, many of which interfere with folate metabolism, thus they are considered to have multifactorial causes.) Another

relevance of this folate enzyme's inclusion to the purinosome macrobody is unclear: while it provides substrate for a trifunctional folate enzyme C1THF synthase

FOLR may refer to: FOLR1 (folate receptor 1, adult) FOLR2 (folate receptor 2, fetal) This disambiguation page lists articles associated with the title

Dietary Fiber: 5.74 grams Calcium: 28.7 mg Iron: 0.67 mg Potassium: 895.85 mg Folate: 57.40 mcg Vitamin: A 7,291.85 Systax database at the University of Ulm

Center at Massachusetts General Hospital. His research focuses on anti-folate drugs for the treatment of cancer. His work at NIH led to the development