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Glutamate carboxypeptidase II
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membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximatelyDihydropteroate synthase (397 words) [view diff] exact match in snippet view article find links to article
organisms require reduced folate cofactors for the synthesis of a variety of metabolites. Most microorganisms must synthesize folate de novo because they lackMirvetuximab soravtansine (884 words) [view diff] exact match in snippet view article find links to article
tube cancer, or primary peritoneal cancer. Mirvetuximab soravtansine is a folate receptor alpha directed antibody and microtubule inhibitor conjugate. TheNeurulation (3,288 words) [view diff] exact match in snippet view article find links to article
1186/s12976-016-0037-2 Björklund, NK, Gordon, R A hypothesis linking low folate intake to neural tube defects due to failure of post-translation methylationsFolate receptor 1 (1,756 words) [view diff] exact match in snippet view article find links to article
Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a memberNutritional neuroscience (15,340 words) [view diff] exact match in snippet view article find links to article
against folate receptor alpha have been found in up to 75% of children with autism. Folate deficiency most commonly arises from insufficient folate intakeMegaloblastic anemia (1,263 words) [view diff] exact match in snippet view article find links to article
most often due to hypovitaminosis, specifically vitamin B12 deficiency or folate deficiency. Loss of micronutrients may also be a cause. Megaloblastic anemiaProstate cancer (9,190 words) [view diff] no match in snippet view article find links to article
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of theNucleotide salvage (736 words) [view diff] no match in snippet view article find links to article
A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substanceFolylpolyglutamate synthase (852 words) [view diff] exact match in snippet view article find links to article
for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folateSulfamethoxazole (982 words) [view diff] exact match in snippet view article find links to article
intermediate interferes with the normal bacterial synthesis of folic acid (folate). Folate is an essential metabolite for bacterial growth and replication becauseGamma-glutamyl hydrolase (981 words) [view diff] exact match in snippet view article find links to article
polyglutamates and glutamate. Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidaseDihydrofolate reductase inhibitor (437 words) [view diff] exact match in snippet view article find links to article
function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may beInosine monophosphate synthase (788 words) [view diff] exact match in snippet view article find links to article
"Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylateFarletuzumab (199 words) [view diff] exact match in snippet view article find links to article
ovarian cancer. This drug was developed by Morphotek, Inc. It is targeted at folate receptor alpha (FRα) which is overexpressed in some cancers such as epithelialSerine hydroxymethyltransferase (2,378 words) [view diff] exact match in snippet view article find links to article
However, because the folates used by folate metabolic and folate-dependent enzymes are all very similar in structure and folate mimics are already commonKearns–Sayre syndrome (2,872 words) [view diff] exact match in snippet view article find links to article
cerebral folate deficiency in the Kearns–Sayre syndrome is the failure of the mechanisms in the choroid plexus that are responsible for passage of folates fromPhosphoribosylglycinamide formyltransferase (1,775 words) [view diff] exact match in snippet view article find links to article
lies. The cleft consists of the GAR binding site and the folate-binding pocket. The folate-binding pocket is delineated by pteridine-binding cleft, theNukazuke (1,177 words) [view diff] exact match in snippet view article find links to article
the intestinal flora. These bacteria are also responsible for producing folate and vitamin B12 in nukazuke. Further, since nukazuke absorb nutrients fromEpigenetics of autism (6,254 words) [view diff] exact match in snippet view article find links to article
in folate levels or folate metabolism could significantly impact DNA methylation and contribute to what causes autism. This idea is what makes folate pathwaysJuno (protein) (538 words) [view diff] exact match in snippet view article
known as folate receptor 4, folate receptor delta or IZUMO1R is a protein that in humans is encoded by the FOLR4 gene. Juno is a member of the folate receptorGram-negative bacteria (2,751 words) [view diff] exact match in snippet view article find links to article
beta-lactam-betalactamase inhibitor combinations (such as piperacillin-tazobactam), folate antagonists, quinolones, and carbapenems. Many of these antibiotics alsoPyrimethamine (3,121 words) [view diff] exact match in snippet view article find links to article
reactions, and bone marrow suppression. It should not be used by people with folate deficiency that has resulted in anemia. There is concern that it may increasePralatrexate (634 words) [view diff] exact match in snippet view article find links to article
cancerous cells take in natural folate through a protein identified as plasma membrane transporter (now referred to as "reduced folate carrier type 1" or "RFC-1")Whitefish (fisheries term) (367 words) [view diff] exact match in snippet view article
Pantothenic acid 1.48 mg Vitamin B-6 0.594 mg Folate, total 29.7 μg Folic acid 0 μg Folate, food 29.7 μg Folate, DFE 29.7 μg Choline, total 129 mg VitaminFOLR2 (785 words) [view diff] exact match in snippet view article find links to article
Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folate receptor (FOLR)Folate targeting (3,023 words) [view diff] exact match in snippet view article find links to article
vitamin, folate (folic acid), to a molecule/drug to form a "folate conjugate". Based on the natural high affinity of folate for the folate receptor proteinMisu (235 words) [view diff] exact match in snippet view article find links to article
beverage is high in protein, vitamins, calcium, magnesium, molybdenum, folate, and selenium, and is a dieter's drink, as it is quite filling but low inMacrocytic anemia (1,269 words) [view diff] exact match in snippet view article find links to article
suggests megaloblastosis and is commonly seen in Vitamin B12 deficiency and folate deficiency. This type of anemia is caused by impaired DNA synthesis andNutrition and cognition (3,091 words) [view diff] exact match in snippet view article find links to article
Concentrations of blood plasma folate and homocysteine concentrations are inversely related, such that an increase in dietary folate decreases homocysteine concentrationPancytopenia (794 words) [view diff] exact match in snippet view article find links to article
Dyskeratosis congenita Myelodysplastic syndrome Leukemia Leishmaniasis Severe folate or vitamin B12 deficiency Systemic lupus erythematosus Paroxysmal nocturnalMTRR (gene) (5,274 words) [view diff] exact match in snippet view article
methionine synthase (MTR). The folate cycle is linked to homocysteine metabolism via MTR. Circulating blood folate (5-methyl tetrahydrofolate, 5-MTHF)Nutriepigenomics (6,399 words) [view diff] exact match in snippet view article find links to article
used in DNA methylation are often derived from dietary sources, such as folate and choline, and explains why diet can have a significant impact on methylationThymidylate synthase inhibitor (380 words) [view diff] exact match in snippet view article find links to article
945/ ONX-0801 OSI-7904L CB300638 Jackman AL, Calvert AH (November 1995). "Folate-based thymidylate synthase inhibitors as anticancer drugs". Annals of OncologyFOLR3 (297 words) [view diff] exact match in snippet view article find links to article
Folate receptor gamma is a protein that in humans is encoded by the FOLR3 gene. It is involved in up-take of folic acid. The FOLR multi-gene family (FOLR1Raltitrexed (311 words) [view diff] exact match in snippet view article find links to article
class of chemotherapy drugs called folate antimetabolites, which inhibit one or more of three enzymes that use folate and derivatives as substrates: DHFR6-Pyruvoyltetrahydropterin synthase deficiency (1,336 words) [view diff] exact match in snippet view article find links to article
also been reported. Patients with mild phenotypes may deteriorate if given folate antagonists such as methotrexate, which can interfere with a salvage pathwaySchilling test (1,097 words) [view diff] exact match in snippet view article find links to article
is not occurring due to damage to the intestinal mucosa from the B12 and folate deficiency themselves. In the first part of the test, the patient is givenAminodeoxychorismate synthase (852 words) [view diff] exact match in snippet view article find links to article
precursor for the production of folates. Folates are family of cofactors that are essential for living organisms. Folate cofactors are used in several one-carbonPTS (gene) (823 words) [view diff] exact match in snippet view article
6-pyruvoyltetrahydropterin synthase, also known as PTS, is a human gene which facilitates folate biosynthesis. 6-pyruvoyltetrahydropterin synthase 6-PyruvoyltetrahydropterinFormylation (2,838 words) [view diff] exact match in snippet view article find links to article
antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotideHelen Keller International (1,318 words) [view diff] exact match in snippet view article find links to article
treating refractive error. Its nutrition programs include vitamin A, iron/folate, and multi-micronutrient supplementation, fortification of commonly usedBinding protein (263 words) [view diff] exact match in snippet view article find links to article
Calmodulin-binding proteins Iron-binding proteins Thyroxine-binding proteins Folate-binding protein Sterol regulatory element-binding protein GTP-binding proteinONX-0801 (525 words) [view diff] exact match in snippet view article find links to article
experimental drug that has been developed to target ovarian cancer. It is a folate receptor alpha mediated thymidylate synthase inhibitor. ONX-0801 was originallyRiboflavin-responsive exercise intolerance (431 words) [view diff] exact match in snippet view article find links to article
caused by mutations of the SLC25A32 gene that encodes the mitochondrial folate transporter. Patients suffer from exercise intolerance and may have disruptedEndocyte (663 words) [view diff] exact match in snippet view article find links to article
small molecule drug conjugate consisting of a small molecule targeting the folate receptor, which is expressed on many cancers, such as ovarian cancer, andDavid S Rosenblatt (408 words) [view diff] exact match in snippet view article find links to article
2013. He is known for his contributions to the field of inborn errors of folate and vitamin B12 metabolism. Rosenblatt received a Bachelor of Science fromDihydrofolate reductase deficiency (263 words) [view diff] exact match in snippet view article find links to article
reductase deficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder is inheritedNicotinamide adenine dinucleotide phosphate (1,653 words) [view diff] exact match in snippet view article find links to article
metabolism-related pathway involved in the generation of NADPH is the mitochondrial folate cycle, which uses principally serine as a source of one-carbon units to3-Dehydroquinic acid (294 words) [view diff] exact match in snippet view article find links to article
and some vitamins, including: Vitamin K Pteroylmonoglutamic acid, called folate. 3-Dehydroquinate can also be a precursor to pyrroloquinoline quinone (PQQ)LabCorp v. Metabolite, Inc. (706 words) [view diff] exact match in snippet view article find links to article
reproduced in full below: "A method for detecting a deficiency of cobalamin or folate in warm-blooded animals comprising the steps of: "assaying a body fluidDihydrofolate reductase deficiency (263 words) [view diff] exact match in snippet view article find links to article
reductase deficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder is inheritedFolate-biopterin transporter family (372 words) [view diff] exact match in snippet view article find links to article
The folate-biopterin transporter (FBT) family (TC# 2.A.71) is a distant family within the major facilitator superfamily, most closely related to drug resistanceFertility medication (2,599 words) [view diff] exact match in snippet view article find links to article
amounts of studies and participants, more clinical studies are needed. Folate in combination with zinc supplementation was shown to have a statisticallyReduced folate carrier family (624 words) [view diff] exact match in snippet view article find links to article
Reduced Folate Carrier (RFC) Family (TC# 2.A.48) is a group of transport proteins that is part of the major facilitator superfamily. RFCs take up folate, reducedInternational Working Group on Neurotransmitter Related Disorders (195 words) [view diff] exact match in snippet view article find links to article
6-pyruvoyl-tetrahydropterin synthase, dihydropteridine reductase, sepiapterin reductase, folate receptor alpha, dihydrofolate reductase, 3-phosphoglycerate dehydrogenaseALDH1L1 (582 words) [view diff] exact match in snippet view article find links to article
Hartge P, et al. (2007). "Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEERLisa Houghton (653 words) [view diff] exact match in snippet view article find links to article
University of Toronto. Her thesis was "The effect of folate supplementation on folate status and breastmilk folate concentration in lactating women". HoughtonFolate-biopterin transporter family (372 words) [view diff] exact match in snippet view article find links to article
The folate-biopterin transporter (FBT) family (TC# 2.A.71) is a distant family within the major facilitator superfamily, most closely related to drug resistanceDyserythropoiesis (199 words) [view diff] exact match in snippet view article find links to article
Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV infection, and certain medications (e.gALDH1L1 (582 words) [view diff] exact match in snippet view article find links to article
Hartge P, et al. (2007). "Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEERDihydropteridine reductase deficiency (476 words) [view diff] exact match in snippet view article find links to article
folinic acid, a form of folate that efficiently passes the hematoencephalic barrier. The use of folic acid, the synthetic form of folate employed in food fortificationPafolacianine (775 words) [view diff] exact match in snippet view article find links to article
fluorescence-guided surgery. Pafolacianine is a fluorescent medication that binds to folate receptor (FR)-expressing cells. The most common side effects of pafolacianineDihydropteridine reductase deficiency (476 words) [view diff] exact match in snippet view article find links to article
folinic acid, a form of folate that efficiently passes the hematoencephalic barrier. The use of folic acid, the synthetic form of folate employed in food fortificationOSI-7904 (222 words) [view diff] exact match in snippet view article find links to article
liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity. As a thymidylate synthase inhibitorReticulocytopenia (1,342 words) [view diff] exact match in snippet view article find links to article
Congenital dyserythropoietic anemia Malnutrition - (e.g. deficiencies in B12, folate, iron) Sequelae of malignancy, connective tissue disease, autoimmune diseaseRachischisis (1,314 words) [view diff] exact match in snippet view article find links to article
slightly higher chance that females will develop the condition over males. Folate deficiency is also a well-accepted risk factor of all neural tube defectsComplications of diabetes (7,357 words) [view diff] exact match in snippet view article find links to article
of endothelial NO synthase enzyme might be potentially elevated by folate, folate supplementation might be capable of restoring the availability of NON-acetyltransferase 1 (616 words) [view diff] exact match in snippet view article find links to article
This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms haveMethylenetetrahydrofolate—tRNA-(uracil-5-)-methyltransferase (214 words) [view diff] exact match in snippet view article
(uracil-5-)-methyl-transferase. Other names in common use include (FADH2-oxidizing), folate-dependent ribothymidyl synthase, methylenetetrahydrofolate-transfer ribonucleateAlec Coppen (448 words) [view diff] exact match in snippet view article find links to article
in depression from 1970, and consistently found low plasma and red cell folate in patients with severe depression. He also showed that a folic acid supplementMihai Ioan Botez (963 words) [view diff] exact match in snippet view article find links to article
Peyronnard JM, Bachevalier J, Charron L (September 1978). "Polyneuropathy and folate deficiency". Archives of Neurology. 35 (9): 581–4. doi:10.1001/archneurAlec Coppen (448 words) [view diff] exact match in snippet view article find links to article
in depression from 1970, and consistently found low plasma and red cell folate in patients with severe depression. He also showed that a folic acid supplementInternational Meeting for Autism Research (466 words) [view diff] exact match in snippet view article find links to article
Another paper presented there focused on the prevalence of autoantibodies to folate receptors in autistic children, and found that about 75% of children withThymidylate synthase (1,902 words) [view diff] exact match in snippet view article find links to article
the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised duringCapicua (protein) (1,435 words) [view diff] exact match in snippet view article
been shown to affect the expression of folate receptor alpha, and CIC mutations might result in cerebral folate deficiency. ATXN1 — capicua and ataxinMay–Grünwald stain (139 words) [view diff] exact match in snippet view article find links to article
Y., Toriumi, N., Sarashina, T. et al. An infantile case of hereditary folate malabsorption with sudden development of pulmonary hemorrhage: a case reportDIP2B (239 words) [view diff] exact match in snippet view article find links to article
that DIP2B may participate in DNA methylation. This gene is located near a folate-sensitive fragile site. GRCh38: Ensembl release 89: ENSG00000066084 – EnsemblList of medical mnemonics (4,281 words) [view diff] exact match in snippet view article find links to article
Low dietary intake Infection with Giardia Celiac sprue Dilantin Relative folate deficiency Old Pregnant ABCD: Anderson's = Branching enzyme Cori's = DebranchingThrombocytopenia (2,886 words) [view diff] exact match in snippet view article find links to article
Thrombocytopenia in hospitalized alcoholics may be caused by spleen enlargement, folate deficiency, and most frequently, the direct toxic effect of alcohol on productionHaptocorrin (1,810 words) [view diff] exact match in snippet view article find links to article
FC, Smith AD, Martin RM (Nov 2010). "Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigenMethylation (3,059 words) [view diff] exact match in snippet view article find links to article
epigenetics. Sources of methyl groups include S-methylmethionine, methyl folate, methyl B12. Methanogenesis, the process that generates methane from CO2Lubani Al Saleh Teebi syndrome (181 words) [view diff] exact match in snippet view article find links to article
consists of cystic fibrosis, helicobacter pylori-associated gastritis, folate-deficiency megaloblastic anemia and intellectual disabilities. This disorderMTHFD1 (1,118 words) [view diff] exact match in snippet view article find links to article
JS, Kaplan BS, Nunez LD, et al. (September 2011). "Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutationsMechouia salad (217 words) [view diff] exact match in snippet view article find links to article
disease and cancer. They are also a great source of vitamin C, potassium, folate and vitamin K. Contains fiber, vitamin E and C. North Africans use it toSulfadoxine (160 words) [view diff] exact match in snippet view article find links to article
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.[citation needed] Sulfadoxine/pyrimethamine Scholia has a topicNanomaterials (10,228 words) [view diff] exact match in snippet view article find links to article
uses Folate Receptors (FR) to detect tumor lesions as small as 370 micrometers. Folate Receptors are membrane bound surface proteins that bind folates andRubus idaeus (1,156 words) [view diff] exact match in snippet view article find links to article
sweet taste and are very aromatic. Red raspberries contains 31 μg/100 g of folate. Red raspberries have antioxidant effects that play a minor role in theFumonisin B1 (3,218 words) [view diff] exact match in snippet view article find links to article
out folate deficiency as a major risk factor for neural tube defects. FB1 disrupts sphingolipid metabolism and therefore this could affect folate uptakeFumonisin B1 (3,218 words) [view diff] exact match in snippet view article find links to article
out folate deficiency as a major risk factor for neural tube defects. FB1 disrupts sphingolipid metabolism and therefore this could affect folate uptakeFosphenytoin (537 words) [view diff] exact match in snippet view article find links to article
subsequently metabolized to formate, which is in turn metabolized by a folate dependent mechanism. Side effects are similar to intravenous phenytoin andYoung-In Kim (678 words) [view diff] exact match in snippet view article find links to article
the molecular and clinical aspects of nutrition and cancer, particularly folate metabolism, colorectal and breast cancer prevention, and epigenetics.[citationPrenatal vitamin (794 words) [view diff] exact match in snippet view article find links to article
compounds play in fetal development. The increased dosage of folic acid or folates reflects the American Dietetic Associations position that women shouldSutro Biopharma (638 words) [view diff] exact match in snippet view article find links to article
is currently in a Phase I clinical trial. STRO-002 is an ADC targeting folate receptor alpha, a cell-surface protein highly expressed in gynecologicalList of hematologic conditions (2,600 words) [view diff] exact match in snippet view article find links to article
Invest. 56 (5): 1125–1131. doi:10.1172/JCI108187. PMC 301974. PMID 1184739. "Folate-deficiency anemia". National Center for Biotechnology Information. U.S.Dendrimer (6,944 words) [view diff] exact match in snippet view article find links to article
PMID 27422195. Singh P, Gupta U, Asthana A, Jain NK (November 2008). "Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancerStephen J. Benkovic (3,270 words) [view diff] exact match in snippet view article find links to article
S. J., and Wright, P. E. (1995) Dynamics of the dihydrofolate reductase—folate complex: Catalytic sites and regions known to undergo conformational changeDasheri (288 words) [view diff] exact match in snippet view article find links to article
zinc, vitamin E, iron, calcium, and other quantities of zinc, vitamin A, folate, and other minerals that support proper organ function. Dasheri mangoesStephen J. Benkovic (3,270 words) [view diff] exact match in snippet view article find links to article
S. J., and Wright, P. E. (1995) Dynamics of the dihydrofolate reductase—folate complex: Catalytic sites and regions known to undergo conformational changeBruce Chabner (401 words) [view diff] exact match in snippet view article find links to article
pharmacology most notably includes his contributions to developing anti-folate drugs for the treatment of cancer. His work at NIH led to the developmentPhenytoin (4,761 words) [view diff] exact match in snippet view article find links to article
known to be a causal factor in the development of peripheral neuropathy. Folate is present in food in a polyglutamate form, which is then converted intoRed Pecorino (267 words) [view diff] exact match in snippet view article find links to article
as "Picurinu Rusu". Red Pecorino is made from sheep's milk and Sicilian folate pastes in a technique known as pasta filata which is used in the manufacturePLCG2 (1,405 words) [view diff] exact match in snippet view article find links to article
(1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portionRed kuri squash (503 words) [view diff] exact match in snippet view article find links to article
Dietary Fiber: 5.74 grams Calcium: 28.7 mg Iron: 0.67 mg Potassium: 895.85 mg Folate: 57.40 mcg Vitamin: A 7,291.85 Systax database at the University of UlmCleft lip and cleft palate (10,276 words) [view diff] exact match in snippet view article find links to article
lip palate incidence. The mechanism behind beneficial folate supplementation is due to folate playing a pivotal role in DNA synthesis and methylationCampesterol (1,240 words) [view diff] exact match in snippet view article find links to article
Antonia; Ros, Emilio (2007). "Other relevant components of nuts: Phytosterols, folate and minerals". British Journal of Nutrition. 96: S36–44. doi:10.1017/BJN20061862Purinosome (1,672 words) [view diff] exact match in snippet view article find links to article
relevance of this folate enzyme's inclusion to the purinosome macrobody is unclear: while it provides substrate for a trifunctional folate enzyme C1THF synthaseFRA10AC1 (313 words) [view diff] exact match in snippet view article find links to article
associated with any disease phenotype. This gene is found within the rare FRA10A folate-sensitive fragile site. GRCh38: Ensembl release 89: ENSG00000148690 – EnsemblDNA photolyase N-terminal domain (586 words) [view diff] exact match in snippet view article find links to article
cofactor may be either the pterin 5,10-Methenyltetrahydrofolate (MTHF, MHF) in folate photolyases (PDB: 4U63) or the deazaflavin 8-hydroxy-7,8-didemethyl-5-deazariboflavin