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Longer titles found: Initial volume of distribution (view), Table of volume of distribution for drugs (view)

searching for Volume of distribution 105 found (255 total)

Analgesic (5,853 words) [view diff] exact match in snippet view article find links to article

PO, IM, IV. Bioavailability = 80–100%; protein binding > 99%; volume of distribution = 0.11 L/kg; hepatic metabolism; half-life = 8–12 hours; excretion

Difloxacin (1,424 words) [view diff] exact match in snippet view article find links to article

body clearance/F = Dose/AUC b Steady state volume of distribution/F = Dose•AUMC/AUC2 c Volume of distribution (area)/F = Vdβ = (T1/2)(CL/F)/0.693 As mentioned

Kt/V (2,863 words) [view diff] exact match in snippet view article find links to article

adequacy. K – dialyzer clearance of urea t – dialysis time V – volume of distribution of urea, approximately equal to patient's total body water In the

Meloxicam (3,717 words) [view diff] exact match in snippet view article find links to article

following oral administration is approximately 5–6 hours. The mean volume of distribution of meloxicam is approximately 10 L. It is highly protein-bound,

Clotiazepam (1,106 words) [view diff] exact match in snippet view article find links to article

in elderly women the volume of distribution is increased. Individuals with liver impairment have a reduced volume of distribution as well as a reduced

Ixekizumab (1,451 words) [view diff] exact match in snippet view article find links to article

degraded by proteolysis. Its elimination half-life is 14–18 days. The volume of distribution is 7.11 L. Mean clearance is 0.39 L/day. There is no difference

Grapiprant (1,027 words) [view diff] exact match in snippet view article find links to article

not administered with food as it will not be as efficient. The volume of distribution in cat studies was reported to be 918 ml/kg. Following an oral administration

Ampicillin/sulbactam (2,043 words) [view diff] exact match in snippet view article find links to article

Ampicillin and sulbactam are both hydrophilic antibiotics and have a volume of distribution (Vd) similar to the volume of extra-cellular body water. The volume

Prajmaline (827 words) [view diff] exact match in snippet view article find links to article

Oral bioavailability is 80%. Elimination half-life is 6 hours. Volume of distribution is 4-5 L/kg. There are no significant adverse side-effects of Prajmaline

Guselkumab (977 words) [view diff] exact match in snippet view article find links to article

otherwise be activated by its presence. Cmax 8.09 μg/mL tmax 5.5 days volume of distribution 13.5 L apparent clearance 0.516 L/day Guselkumab was developed by

Tedizolid (946 words) [view diff] exact match in snippet view article find links to article

binding to plasma proteins (80%), longer half-life, and a larger volume of distribution compared to linezolid. It is primarily metabolized by the liver

Methyprylon (451 words) [view diff] exact match in snippet view article find links to article

apparent clearance, (11.91 +/- 4.42 mL/h/kg) and apparent steady-state volume of distribution, (0.97 +/- 0.33 L/kg) were found. A case report found that the pharmacokinetics

Encephalitis (2,539 words) [view diff] exact match in snippet view article find links to article

moderately lipophilic at pH of 7.4, low level of plasma protein binding, volume of distribution of litre per kg, does not have strong affinity towards binding with

Protopanaxadiol (508 words) [view diff] exact match in snippet view article find links to article

concentration, but no data is given for oral bioavailbility, half life, or volume of distribution. In rats, the oral bioavailbility is about 48% and the half-life

Tocainide (525 words) [view diff] exact match in snippet view article find links to article

2 hours). In the blood, tocainide is 10-20% protein bound. The volume of distribution is 2.8-3.2 L/kg. 31-45% is excreted unchanged in the urine. The

Doripenem (881 words) [view diff] exact match in snippet view article find links to article

humans (18.2 L). When doripenem is essentially stable, the average volume of distribution is approximately 16.8 L. Within the few of the body’s fluids and

Furosemide (3,611 words) [view diff] exact match in snippet view article find links to article

disease 43 – 46% % Protein binding 91 – 99 Volume of distribution (L/kg) 0.07 – 0.2 Volume of distribution may be higher in patients with cirrhosis or

Lamotrigine (6,694 words) [view diff] exact match in snippet view article find links to article

lamotrigine follow first-order kinetics, with a half-life of 29 hours and volume of distribution of 1.36 L/kg. Lamotrigine is rapidly and completely absorbed after

Benzodiazepine overdose (4,044 words) [view diff] exact match in snippet view article find links to article

little effect on the clearance of benzodiazepines due to their large volume of distribution and lipid solubility. Supportive measures include observation of

Alvimopan (755 words) [view diff] exact match in snippet view article find links to article

available alvimopan is bound to plasma protein. At steady state, the volume of distribution is approximately 30 liters. Alvimopan undergoes no significant hepatic

Ibutilide (708 words) [view diff] exact match in snippet view article find links to article

viable during the clinical trial. Ibutilide has a relatively large volume of distribution among individual subjects, which is about 11L/kg. Approximately

Abituzumab (974 words) [view diff] exact match in snippet view article find links to article

which may suggest saturable first-order elimination kinetics. Volume of distribution remained constant between 4.1 - 5.9 L at all doses of Abituzumab

Bisoprolol (2,864 words) [view diff] exact match in snippet view article find links to article

plasma protein binding of bisoprolol is approximately 35%, the volume of distribution is 3.5 L/kg and the total clearance is approximately 15 L/h. Bisoprolol

Dextromoramide (1,198 words) [view diff] exact match in snippet view article find links to article

Dextromoramide has a mean elimination half life of 215.3 ± 78.4 minutes and volume of distribution of 0.58 ± 0.20 L/kg. Peak plasma levels are reached within 0.5–4

Cephaloridine (1,847 words) [view diff] exact match in snippet view article find links to article

clearance of 125 ml/min/1,73m2. A serum half-life of 1,1-1,5 hour and a volume of distribution of 16 liters were reported. Pharmacokinetic analysis is not possible

Tiapride (1,700 words) [view diff] exact match in snippet view article find links to article

virtually no binding to plasma proteins, giving it a relatively high volume of distribution. Benzamide and its derivatives are highly water-soluble, and because

Metoprolol (2,646 words) [view diff] exact match in snippet view article find links to article

serum albumin with an unbound fraction of 0.88. It has a large volume of distribution at steady state (3.2 L/kg), indicating extensive distribution throughout

Delorazepam (1,950 words) [view diff] exact match in snippet view article find links to article

failure on haemodialysis have a slow elimination rate and a reduced volume of distribution of the drug. Liver disease has a profound effect on the elimination

Fomepizole (884 words) [view diff] exact match in snippet view article find links to article

avoided. Fomepizole distributes rapidly into total body water. The volume of distribution is between 0.6 and 1.02 L/kg. The therapeutic concentration is from

Paraxanthine (1,711 words) [view diff] exact match in snippet view article find links to article

and caffeine-derived methylxanthines Plasma half-life (t1/2; hr) Volume of distribution (Vss,unbound; l/kg) Plasma clearance (CL; ml/min/kg) Caffeine 4

Prednisone (2,723 words) [view diff] exact match in snippet view article find links to article

gastrointestinal tract and has a half-life of 2–3 hours. it has a volume of distribution of 0.4–1 L/kg. The drug is cleared by hepatic metabolism using cytochrome

Imipenem/cilastatin/relebactam (1,203 words) [view diff] exact match in snippet view article find links to article

is 20% for imipenem, 20% for cilastatin and 22% for relebactam; volume of distribution is 24.3 L for imipenem and cilastatin and 19 L for relebactam. The

Creatine (6,548 words) [view diff] exact match in snippet view article find links to article

pharmacokinetic parameters for clinical usage of creatine such as volume of distribution, clearance, bioavailability, mean residence time, absorption rate

Bilastine (2,692 words) [view diff] exact match in snippet view article find links to article

after 14 days of treatment. Bilastine distribution has an apparent volume of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h and plasma

Batroxobin (2,033 words) [view diff] case mismatch in snippet view article find links to article

batroxobin after administration. All the species showed a large Vd (Volume of Distribution). The value of the plasma in animals was around 50ml/kg on average

Omeprazole (3,835 words) [view diff] exact match in snippet view article find links to article

omeprazole after repeated doses is about 60%. Omeprazole has a volume of distribution of 0.4 L/kg. It has high plasma protein binding of 95%. Omeprazole

Cinnarizine (3,197 words) [view diff] exact match in snippet view article find links to article

ending with a very slow elimination. The Vss (steady state apparent volume of distribution) for lipid emulsion administration was 2× lower (6.871 ± 1.432 L/kg)

Aspirin (16,978 words) [view diff] exact match in snippet view article find links to article

salicylate and increased toxicity. The volume of distribution is 0.1–0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue

Trospium chloride (2,095 words) [view diff] exact match in snippet view article find links to article

of 3H-trospium chloride is distributed in plasma. The apparent volume of distribution for a 20 mg oral dose is 395 (± 140) liters. The metabolic pathway

Thyroid function tests (3,677 words) [view diff] exact match in snippet view article find links to article

{\displaystyle \alpha _{T}} : Dilution factor for T4 (reciprocal of apparent volume of distribution, 0.1 l−1) β T {\displaystyle \beta _{T}} : Clearance exponent for

Deguelin (667 words) [view diff] exact match in snippet view article find links to article

Total clearance (Cl) = 4.37 L/h per kg Apparent volume of distribution (V) = 3.421 L/kg Volume of distribution at steady-state (Vss) = 30.46 L/kg Tissue distributions

Loop diuretic (2,419 words) [view diff] exact match in snippet view article find links to article

Loop diuretics are highly protein bound and therefore have a low volume of distribution. The protein bound nature of the loop diuretic molecules causes

Kidney dialysis (5,575 words) [view diff] exact match in snippet view article find links to article

protein binding capacity Prolonged elimination (long half-life) Small volume of distribution Ethylene glycol Procainamide Methanol Isopropyl alcohol Barbiturates

Uremia (3,277 words) [view diff] exact match in snippet view article find links to article

produced by gut bacteria Aliphatic amines dimethylamine choline large volume of distribution, produced by gut bacteria Polyols CMPF unknown tightly protein bound

Levetiracetam (3,486 words) [view diff] exact match in snippet view article find links to article

100 percent, and the effect of food on absorption is minor. The volume of distribution of levetiracetam is similar to total body water. Levetiracetam modestly

Cefditoren (1,999 words) [view diff] exact match in snippet view article find links to article

Binding of cefditoren to plasma proteins averages 88%, and the mean volume of distribution of cefditoren at steady state is 9.3L. Cefditoren has been shown

Bortezomib (2,272 words) [view diff] exact match in snippet view article find links to article

which the levels rapidly drop as the drug distributes to tissues (volume of distribution is ~500 L). Both routes provide equal drug exposures and generally

Electron transport chain (4,073 words) [view diff] exact match in snippet view article find links to article

thousands of meters below the surface of Earth. Because of their volume of distribution, lithotrophs may actually outnumber organotrophs and phototrophs

Dronedarone (2,144 words) [view diff] exact match in snippet view article find links to article

Dronedarone is less lipophilic than amiodarone, has a much smaller volume of distribution, and has an elimination half-life of 13–19 hours—this stands in

Enoxaparin sodium (1,654 words) [view diff] exact match in snippet view article find links to article

Absorption: Bioavailability (subcutaneous injection) ~ 100% Distribution: Volume of distribution (anti-Factor Xa activity) = 4.3 liters Metabolism: Enoxaparin is

Mobocertinib (1,055 words) [view diff] exact match in snippet view article find links to article

at a lower concentration than it does on wild-type proteins. The volume of distribution of Mobocertinib at steady state is 3,509 L. The mean oral bioavailability

Adrenomedullin (2,597 words) [view diff] exact match in snippet view article find links to article

half-life of 22min, mean clearance rate of 27.4 mL/kg/min, and apparent volume of distribution of 880 ± 150 mL/kg. Adrenomedullin consists of 52 amino acids, has

Lorazepam (8,688 words) [view diff] exact match in snippet view article find links to article

solubility and a high degree of protein binding (85–90%) mean that its volume of distribution is mainly the vascular compartment, causing relatively prolonged

Repinotan (2,572 words) [view diff] exact match in snippet view article find links to article

ensues in parallel from plasma and brain. In addition, repinotan's volume of distribution at steady-state and plasma clearance are independent of dose. This

Irinotecan (2,315 words) [view diff] exact match in snippet view article find links to article

three weeks. Irinotecan is a hydrophilic compound with a large volume of distribution (400 L/m2). At physiological pH, irinotecan and its active metabolite

Venetoclax (2,683 words) [view diff] exact match in snippet view article find links to article

recommended that venetoclax be administered with a meal. The apparent volume of distribution for venetoclax is approximately 256–321 L. It is highly bound to

Theophylline (2,256 words) [view diff] exact match in snippet view article find links to article

placenta, in the mother's milk and in the central nervous system. The volume of distribution is 0.5 L/kg. The protein binding is 40%.[medical citation needed]

Glucocorticoid (5,542 words) [view diff] exact match in snippet view article find links to article

differ in both pharmacokinetics (absorption factor, half-life, volume of distribution, clearance) and pharmacodynamics (for example the capacity of mineralocorticoid

Acepromazine (1,709 words) [view diff] exact match in snippet view article find links to article

US: ℞-only Pharmacokinetic data Bioavailability 6.6 L/kg, high volume of distribution Elimination half-life 3 hours in horses, 15.9 hours in canines Excretion

Fluid compartments (1,423 words) [view diff] exact match in snippet view article find links to article

Compartment (pharmacokinetics) Distribution (pharmacology) and volume of distribution Rodney A. Rhoades; David R. Bell (18 January 2012). Medical Physiology:

Paroxetine (7,381 words) [view diff] exact match in snippet view article find links to article

Paroxetine exhibits significant interindividual variations in volume of distribution and clearance. Less than 2% of an oral dose is excreted in urine

Alcoholism (15,195 words) [view diff] exact match in snippet view article find links to article

weight and higher percentage of body fat and therefore a lower volume of distribution for alcohol than men. Long-term misuse of alcohol can cause a wide

Nanomedicine (6,144 words) [view diff] exact match in snippet view article find links to article

regulated drug release; reduce drug clearance rates; or lower the volume of distribution and reduce the effect on non-target tissue. However, the biodistribution

Ceftolozane/tazobactam (2,207 words) [view diff] exact match in snippet view article find links to article

binding of tazobactam is approximately 30%. The mean steady-state volume of distribution in healthy adult males after a single 1.5 g IV dose is 13.5 L for

Haloperidol (5,448 words) [view diff] exact match in snippet view article find links to article

seen within seconds. The T1/2 is 14.1 to 26.2 hours. The apparent volume of distribution is between 9.5 and 21.7 L/kg. The duration of action is four to

Zolmitriptan (2,498 words) [view diff] exact match in snippet view article find links to article

average, zolmitriptan has an oral bioavailability of 40%, a mean volume of distribution of 8.3 L/kg after oral administration, and 2.4L/kg after intravenous

Rasburicase (1,076 words) [view diff] exact match in snippet view article find links to article

and adult patients and ranged from 15.7 to 22.5 hours. The mean volume of distribution of rasburicase ranged from 110 to 127 mL/kg in pediatric patients

Maropitant (2,043 words) [view diff] exact match in snippet view article find links to article

bioavailability. It binds to plasma proteins at a rate of 99.5%; it has a low volume of distribution (9 L/kg) and is thus not extensively absorbed. Subcutaneously administered

Rheumatoid arthritis (17,072 words) [view diff] exact match in snippet view article find links to article

characteristics of Hydroxychloroquine are complex due to the large volume of distribution, significant tissue binding, and long terminal elimination half-life

Valsartan/hydrochlorothiazide (1,209 words) [view diff] exact match in snippet view article find links to article

the urine (60-70%). Protein binding ranges between 40 and 70% and volume of distribution varies from 4-8L/kg. "Diovan HCT- valsartan and hydrochlorothiazide

Brincidofovir (2,166 words) [view diff] exact match in snippet view article find links to article

is then phosphorylated to the active cidofovir diphosphate. The volume of distribution of the drug is 1230 L. Because smallpox is eradicated, the effectiveness

Amiodarone (7,668 words) [view diff] exact match in snippet view article find links to article

extensive tissue distribution of amiodarone contributes to a large volume of distribution that leads to slow clearance from plasma compartments; extensive

Amikacin (3,705 words) [view diff] exact match in snippet view article find links to article

should be avoided in infants. Infants also tend to have a larger volume of distribution due to their higher concentration of extracellular fluid, where

Ganirelix (854 words) [view diff] exact match in snippet view article find links to article

the mean (SD) elimination half-life (t1/2) to be 16.2(1.6) hours, volume of distribution/absolute bioavailability (Vd/F) 76.5(10.3) liters, maximum serum

Voclosporin (2,273 words) [view diff] exact match in snippet view article find links to article

estimated to be 7693 ng/mL and the Cmax is estimated at 955 ng/mL. The volume of distribution is approximately 2,154 L and distributes within the red blood cells

Atypical antipsychotic (9,302 words) [view diff] exact match in snippet view article find links to article

antipsychotics Drug Route(s) of Administration Half-life (t1/2 in hours) Volume of distribution (Vd in L/kg) Protein binding Excretion Enzymes involved in metabolism

Chloroquine (5,911 words) [view diff] exact match in snippet view article find links to article

increases its elimination.[citation needed] It has a very high volume of distribution, as it diffuses into the body's adipose tissue.[citation needed]

Tolcapone (2,970 words) [view diff] exact match in snippet view article find links to article

acetylation. The half-life of tolcapone is two to three hours, the volume of distribution (Vd) being 0.3 L/kg (21 L in an average 70 kg person). 60% of the

Pharmacokinetics simulation (115 words) [view diff] exact match in snippet view article find links to article

simulate individual plasma-concentration time curves based on (published) pharmacokinetic parameters such as half-life, volume of distribution etc. v t e

Pholcodine (1,741 words) [view diff] exact match in snippet view article find links to article

binding 23.5% Metabolism Liver Elimination half-life 32-43 hours; volume of distribution is 36-49L/kg. Excretion Kidney Identifiers IUPAC name 7,8-Didehydro-4

Carbetocin (1,918 words) [view diff] exact match in snippet view article find links to article

peptides, primarily on the C-terminal end. Both elimination and volume of distribution are not dose dependent. Carbetocin has been approved for use under

Asciminib (1,751 words) [view diff] exact match in snippet view article find links to article

P-glycoprotein. Asciminib reaches steady state in three days. The volume of distribution of asciminib is 151 L. The efficacy of asciminib in the treatment

Asciminib (1,751 words) [view diff] exact match in snippet view article find links to article

P-glycoprotein. Asciminib reaches steady state in three days. The volume of distribution of asciminib is 151 L. The efficacy of asciminib in the treatment

Discovery and development of cyclooxygenase 2 inhibitors (4,471 words) [view diff] exact match in snippet view article find links to article

plasma proteins, especially to plasma albumin. It has an apparent volume of distribution (VD) of 455 +/- 166 L in humans and the area under the plasma concentration-time

Avalglucosidase alfa (1,197 words) [view diff] exact match in snippet view article find links to article

undergoes cleavage proteolytically and then acts as an enzyme. The volume of distribution of avalglucosidase alfa was 3.4 L in patients who had Pompe disease

Melatonin receptor agonist (2,766 words) [view diff] exact match in snippet view article find links to article

7 h 0.8–5.9 h (terminal) — Protein binding 60% 82% 95% 89–90% — Volume of distribution — 73.6 L 35 L 56–126 L — Company Neurim Pharmaceuticals Takeda Pharmaceutical

Simcyp (611 words) [view diff] exact match in snippet view article find links to article

drug and metabolite concentration–time profiles. Prediction of volume of distribution based on lipophilicity, ionisation, protein binding and tissue composition

Kudo-kai (1,487 words) [view diff] exact match in snippet view article find links to article

(Toru Iwai, a co-founder of Good Enough, for one), and why the volume of distribution of drugs especially methamphetamines and relatively new drugs such

GDNF family of ligands (1,125 words) [view diff] exact match in snippet view article find links to article

to penetrate the blood–brain barrier, and they have very small volume of distribution in the tissues. Therefore, the creation of small-molecule agonists

Antalarmin (3,191 words) [view diff] exact match in snippet view article find links to article

biphasic decline over time. CP-154,526 also demonstrated a large volume of distribution (Vd) at 6.7 L/kg, indicating extensive binding of the drug to tissue

Azalide (366 words) [view diff] exact match in snippet view article find links to article

exhibit, and free azalide concentration/MIC., Due to their large volume of distribution and lipophilic structure, azalides concentrate effectively in tissue

Health effects of alcohol (9,211 words) [view diff] exact match in snippet view article find links to article

McCutcheon, JR; Oliver, RD (September 1996). "Determination of volume of distribution for ethanol in male and female subjects". J Anal Toxicol. 20 (5):

Discovery and development of dipeptidyl peptidase-4 inhibitors (5,080 words) [view diff] exact match in snippet view article find links to article

vildagliptin. Drug Absorption Bioavailability (%) IC50 (nM) Mean volume of distribution (L) Protein binding (%) Half-life (hours,100 mg dose) Metabolism

Development and discovery of SSRI drugs (5,336 words) [view diff] exact match in snippet view article find links to article

of SSRIs tmax = Time to peak plasma level after oral dose; VD = Volume of distribution; t1/2 = Elimination half-life It is recognized that both the position

Alp Ikizler (2,578 words) [view diff] exact match in snippet view article find links to article

Evanson, J, Hakim, RM, Freedman, S, Shyr, Y, Ikizler, TA. Urea volume of distribution exceeds total body water in patients with acute renal failure. Kidney

Klara Valko (1,632 words) [view diff] exact match in snippet view article find links to article

mechanistic models. This approach enabled estimating in vivo unbound volume of distribution (V(du)) and fraction unbound in tissue (f(ut)) during lead optimization

Thyroid's secretory capacity (5,250 words) [view diff] exact match in snippet view article find links to article

{\displaystyle \alpha _{T}} : Dilution factor for T4 (reciprocal of apparent volume of distribution, 0.1 L−1) β T {\displaystyle \beta _{T}} : Clearance exponent for

Sum activity of peripheral deiodinases (4,723 words) [view diff] exact match in snippet view article find links to article

\alpha _{31}} : Dilution factor for T3 (reciprocal of apparent volume of distribution, 0.026 L−1) β 31 {\displaystyle \beta _{31}} : Clearance exponent

Reproductive immunology (4,960 words) [view diff] exact match in snippet view article find links to article

Changes in body composition during pregnancy may change drugs volume of distribution due to increased body weight and fat, increased total plasma volume

Synthetic drug (2,877 words) [view diff] exact match in snippet view article find links to article

of 10.7-15.8 hours in healthy adult patients. Alprazolam has a volume of distribution following oral administration of 0.8-1.3L/kg. Its protein binding

Balanced anesthesia (2,599 words) [view diff] exact match in snippet view article find links to article

distributed fully at equilibrium in the body, which is called the volume of distribution at a stable state. In case the loading dose was administered after

Vutrisiran (2,601 words) [view diff] exact match in snippet view article find links to article

volunteers. Plasma half-life was (4.2–7.5 hours). The apparent volume of distribution of vutrisiran is estimated to be 10.1 L. Vutrisiran is 80% plasma

Rezafungin (591 words) [view diff] exact match in snippet view article find links to article

Rezafungin, while remaining a hydrophilic compound, exhibits a volume of distribution more than twice that of caspofungin. This pharmacokinetic property

Taraxacum mongolicum (1,019 words) [view diff] exact match in snippet view article find links to article

approximately 73%. The extract also increased the drug’s apparent volume of distribution and terminal elimination half-life. However, the overall bioavailability

Osaka Dojima Exchange (6,264 words) [view diff] exact match in snippet view article find links to article

take the lead in price formation[38]. JAs, who want to control the volume of distribution and maintain rice prices and sales commissions at as high a level