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searching for Reactive intermediate 73 found (128 total)

Tienilic acid (614 words) [view diff] exact match in snippet view article find links to article

is a hypothesis. It is still not known (after 15 years) if the reactive intermediate which inactivates the CYP2C9 is the thiophene sulfoxide or the thiophene

Hawkinsinuria (402 words) [view diff] exact match in snippet view article find links to article

In rare cases, however, the enzyme is still able to produce the reactive intermediate 1,2-epoxyphenyl acetic acid, but is unable to convert this intermediate

Deoxyadenosyl radical (135 words) [view diff] exact match in snippet view article find links to article

5′-hydroxy group from adenosine. This radical occurs in nature as a reactive intermediate. It is generated by radical SAM enzymes and by some varieties of

Phosphoenolpyruvate mutase (1,234 words) [view diff] exact match in snippet view article find links to article

appears to interact ionically with Arg159 and His190, stabilizing the reactive intermediate. A phosphoenzyme intermediate is unlikely because the most feasible

Nitrilimine (198 words) [view diff] exact match in snippet view article find links to article

Due to their high energy, they are usually generated in situ as a reactive intermediate. Huisgen, Rolf; Seidel, Michael; Sauer, Juergen; McFarland, James;

N-Acetyldopamine (135 words) [view diff] exact match in snippet view article find links to article

is the N-acetylated derivative of dopamine. This compound is a reactive intermediate in sclerotization, the process by which insect cuticles are formed

Cephaloridine (1,847 words) [view diff] exact match in snippet view article find links to article

Thereafter, probably a combination of events, such as formation of a reactive intermediate, a free radical and stimulation of lipid peroxidation, lead to peroxidative

John E. Bercaw (488 words) [view diff] exact match in snippet view article find links to article

Caltech Directory". Bercaw, John Edward (1971). Titanocene as a reactive intermediate in the reduction of molecular hydrogen and nitrogen (Ph.D.). University

Newman–Kwart rearrangement (565 words) [view diff] exact match in snippet view article find links to article

state (rather than a two-step process passing through a discrete reactive intermediate). The enthalpy of activation for this transition state is generally

Peroxyoxalate (684 words) [view diff] exact match in snippet view article find links to article

involving the transfer of an electron from the fluorescer to the reactive intermediate. The emission of light is thought to result from the annihilation

Broxaterol (284 words) [view diff] case mismatch in snippet view article find links to article

(2017). "Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines". Organic Process Research

Jacobsen epoxidation (802 words) [view diff] exact match in snippet view article find links to article

(similar to the ferryl intermediate of Cytochrome P450) is the reactive intermediate which is formed upon the oxidation of the Mn(III)-salen complex

Atomic carbon (1,513 words) [view diff] case mismatch in snippet view article find links to article

(11): 113506. Bibcode:2014ApPhL.105k3506K. doi:10.1063/1.4895806. Reactive Intermediate Chemistry, Robert A. Moss, Matthew S. Platz and Maitland Jones Jr

Hypobromite (539 words) [view diff] exact match in snippet view article find links to article

on bromide in eosinophils. Hypobromite has been proposed to be a reactive intermediate in the Hofmann rearrangement. Other bromine anions: Topić, Filip;

Pipazetate (389 words) [view diff] exact match in snippet view article find links to article

1-azaphenothiazine-10-carbonyl chloride [94231-78-4] (2). The reaction of this reactive intermediate with 2-[2-(piperidyl)ethoxy]ethanol [3603-43-8] (3) gives the ester

Dihydroxymethylidene (169 words) [view diff] case mismatch in snippet view article find links to article

1002/anie.200802105. PMID 18666191. M. Jones, Jr., R. A. Moss, in "Reactive Intermediate Chemistry", Edited by R. A. Moss, M. S. Platz, M. Jones, Jr., Wiley-Interscience

Carbylamine reaction (219 words) [view diff] exact match in snippet view article find links to article

mechanism involves the addition of amine to dichlorocarbene, a reactive intermediate generated by the dehydrohalogenation of chloroform. Two successive

Methysticin (713 words) [view diff] exact match in snippet view article find links to article

methysticin acts as a mechanism-based inactivator of CYP2C9 through reactive intermediate formation. Malani, Joji (2002-12-03). "Evaluation of the effects

Indicaxanthin (231 words) [view diff] exact match in snippet view article find links to article

derivative) or vitamin C, possibly interfering with perferryl-Hb, a reactive intermediate in the hydroperoxide-dependent Hb degradation. Indicaxanthin in

Halogen addition reaction (815 words) [view diff] exact match in snippet view article find links to article

anti-adduct. In an alternative reaction scheme depicted below the reactive intermediate is a β-bromocarbocation or β-bromocarbonium ion with one of the

Hans Meerwein (340 words) [view diff] exact match in snippet view article find links to article

impact upon organic chemistry was to propose the carbocation 2 as a reactive intermediate, originally as a rationalization of the racemization of isobornyl

Rancidification (1,514 words) [view diff] exact match in snippet view article find links to article

or animal lipoxygenase enzymes, producing a hydroperoxide as a reactive intermediate, as in free-radical peroxidation. The final products depend on conditions:

Methyl carbamate (336 words) [view diff] exact match in snippet view article find links to article

carbamate is used primarily in the textile and polymer industries as a reactive intermediate. In the textile industry, it is used in the manufacture of dimethylol

Lawesson's reagent (689 words) [view diff] exact match in snippet view article find links to article

chemistry of Lawessons's reagent is in fact the chemistry of this reactive intermediate. In general, the more electron rich a carbonyl is, the faster the

Argininosuccinate synthase (1,741 words) [view diff] exact match in snippet view article find links to article

attacks the α-phosphate of ATP to form citrulline adenylate, a reactive intermediate. The attachment of AMP to the ureido (urea-like) group on citrulline

Cytochrome P450 (1,790 words) [view diff] exact match in snippet view article find links to article

referred to as P450 Compound 1 (or just Compound I). This highly reactive intermediate was isolated in 2010, P450 Compound 1 is an iron(IV) oxo (or ferryl)

Ketenyl anion (2,090 words) [view diff] exact match in snippet view article find links to article

Precedent method to obtain this product has been at gas phase or at reactive intermediate, and synthesis of ketene is used be done in extreme conditions (i

Skatole (1,447 words) [view diff] exact match in snippet view article find links to article

cytochrome P450 enzymes in the lungs. These enzymes convert skatole to a reactive intermediate, 3-methyleneindolenine, which damages cells by forming protein adducts

Diphosphomevalonate decarboxylase (1,611 words) [view diff] exact match in snippet view article find links to article

two main stages. First, phosphorylation occurs. This creates a reactive intermediate, which in the second stage undergoes concerted dephosphorylation

Organosilicon chemistry (2,491 words) [view diff] case mismatch in snippet view article find links to article

Matthew S.; Moss, Robert A.; Jones, Maitland (eds.). Reviews of Reactive Intermediate Chemistry. Wiley. pp. 49–51 – via ResearchGate. Ottosson, Henrik;

Hexadehydro Diels–Alder reaction (2,212 words) [view diff] exact match in snippet view article find links to article

acetylene to form ortho-benzyne (o-benzyne, shown below). This reactive intermediate (denoted by brackets) subsequently reacts with a generalized trapping

Polyisocyanurate (1,376 words) [view diff] exact match in snippet view article find links to article

react with itself, producing a stiff, ring molecule, which is a reactive intermediate (a tri-isocyanate isocyanurate compound). Remaining MDI and the

Methenium (620 words) [view diff] exact match in snippet view article find links to article

as an intermediate in the condensed phase. It is proposed as a reactive intermediate that forms upon protonation or hydride abstraction of methane with

Shi epoxidation (1,122 words) [view diff] exact match in snippet view article find links to article

the ketone group on the catalyst (intermediate 1). This forms the reactive intermediate number 2 species, the Criegee intermediate that can potentially

Radical clock (1,004 words) [view diff] case mismatch in snippet view article find links to article

317–323. doi:10.1021/ar50153a004. Moss, R.A.; Platz, M.; Jones, M. Reactive Intermediate Chemistry. Wiley, John & Sons, Incorporated, 2004. 127–128. Fu,

L-DOPA (1,756 words) [view diff] exact match in snippet view article find links to article

The enzyme tyrosinase catalyzes the oxidation of l-DOPA to the reactive intermediate dopaquinone, which reacts further, eventually leading to melanin

Heat-responsive protein 12 (589 words) [view diff] exact match in snippet view article find links to article

Aliases RIDA, P14.5, PSP, UK114, HRSP12, Heat-responsive protein 12, reactive intermediate imine deaminase A homolog, hp14.5 External IDs OMIM: 602487; MGI:

Sulfur mononitride (2,402 words) [view diff] exact match in snippet view article find links to article

a fuel sulfur such as H2S suggests that NS may be an important reactive intermediate in burning of hydrocarbon flames in a reducing atmosphere, which

Biphenylene (1,349 words) [view diff] exact match in snippet view article find links to article

biphenylene structure can also be understood as a dimer of the reactive intermediate benzyne, which in fact serves as a major synthetic route, by heating

Farnesyl-diphosphate farnesyltransferase (3,093 words) [view diff] exact match in snippet view article find links to article

Keeping PSPP in the central channel of SQS is thought to protect the reactive intermediate from reacting with water. From PSPP, squalene is formed by a series

Molnupiravir (3,633 words) [view diff] exact match in snippet view article find links to article

Treatment with 1,2,4-triazole and phosphoryl chloride produces a reactive intermediate in which the triazole portion can be replaced with hydroxylamine

Polyester (5,396 words) [view diff] exact match in snippet view article find links to article

proceeds via the in situ conversion of the carboxylic acid into a more reactive intermediate while the activating agents are consumed. The reaction proceeds

Altanserin (2,364 words) [view diff] exact match in snippet view article find links to article

ketone [84946-22-5] (3). Upon reaction of this reactive intermediate with ethyl anthranilate [87-25-2] (4), the transient addition product

Chlorodifluoromethane (1,745 words) [view diff] exact match in snippet view article find links to article

with strong base and is used in the laboratory as a source of this reactive intermediate. The pyrolysis of R-22 in the presence of chlorofluoromethane gives

Hydroxide (4,882 words) [view diff] exact match in snippet view article find links to article

an organic solvent as well, for example in the generation of the reactive intermediate dichlorocarbene. [H+] denotes the concentration of hydrogen cations

Copper-free click chemistry (878 words) [view diff] exact match in snippet view article find links to article

(MFCO) was introduced that could easily be converted to a useful reactive intermediate for bioconjugation applications, although the reactivity was somewhat

Tyrosine—tRNA ligase (3,787 words) [view diff] exact match in snippet view article find links to article

necessary for converting the substrates tyrosine and ATP into a reactive intermediate, tyrosyl-adenylate (the first step of the aminoacylation reaction)

Fluorodeoxyglucose (18F) (2,499 words) [view diff] no match in snippet view article

potassium and fluoride ions, rendering the fluoride anion more reactive. Intermediate 2 is treated with the protected mannose triflate (1); the fluoride

Difluorodisulfanedifluoride (1,065 words) [view diff] exact match in snippet view article find links to article

disproportionation to sulfur and sulfur tetrafluoride by forming a reactive intermediate HSF molecule. When FSSF3 dissociates, the Fcis atom forms a new

Glutathione S-transferase (4,289 words) [view diff] exact match in snippet view article find links to article

GSTs are responsible for the conjugation of β1-8,9-epoxide, a reactive intermediate formed from aflatoxin B1, which is a crucial means of protection

Phosphorus mononitride (4,718 words) [view diff] exact match in snippet view article find links to article

Synthesis of tris(amido) vanadium PN trimer, dimer, and corresponding monomeric V-NP reactive intermediate from Cummins and coworkers.

Glutathione reductase (3,701 words) [view diff] exact match in snippet view article find links to article

CD, Harley JB, Gilkeson GS (June 2013). "Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different

Lisa McElwee-White (1,496 words) [view diff] case mismatch in snippet view article find links to article

Assessment of the Viability of 1,4,6,9-Spiro4.4Nonatetrayl as a Reactive Intermediate (1984) Doctoral advisor Dennis A. Dougherty Other academic advisors

Sulfur vulcanization (3,224 words) [view diff] exact match in snippet view article find links to article

sulfur. They achieve this by reacting with the sulfur to form a reactive intermediate, referred to as a sulfurating agent. This, in turn, reacts with

Cascade reaction (2,852 words) [view diff] exact match in snippet view article find links to article

2,4,5-hexatetraene 55 and dienophile 56 first formed the highly reactive intermediate 57, which subsequently dimerized to yield [2,2]paracyclophane 58

Peptide synthesis (6,250 words) [view diff] exact match in snippet view article find links to article

proceeds via the formation of a highly reactive O-acylisourea. This reactive intermediate is attacked by the peptide N-terminal amine, forming a peptide bond

Trivalent group 14 radicals (1,737 words) [view diff] case mismatch in snippet view article find links to article

Germanium-, and Tin-Centered Cations, Radicals, and Anions". Reviews of Reactive Intermediate Chemistry. pp. 47–120. doi:10.1002/9780470120828.ch2. ISBN 9780470120828

Living polymerization (4,445 words) [view diff] exact match in snippet view article find links to article

polymers end group to be more reactive this has been referred to as "reactive intermediate polycondensation". The essential result is monomers preferentially

HIV integration (2,137 words) [view diff] exact match in snippet view article find links to article

each viral DNA 3’-end generates a dinucleotide 5’ "overhang" and a reactive intermediate that contains a 3’-hydroxyl group. This 3’ processing step is the

Ubiquitin (11,338 words) [view diff] no match in snippet view article find links to article

resembling eukaryotic E1 and E2 proteins. The structure captures a reactive-intermediate state with the CD-NTase C-terminus positioned in the Cap2 E1 active

Persistent carbene (5,759 words) [view diff] case mismatch in snippet view article find links to article

state); Chapter 5 (singlet state), Roger W. Alder) - ed. Guy Bertrand Reactive Intermediate Chemistry By Robert A. Moss, Matthew Platz, Maitland Jones (Chapter

Phosphiranes (1,017 words) [view diff] exact match in snippet view article find links to article

species decomposes into (Z)-2,2,5,5-tetramethyl-3-hexene and a very reactive intermediate t-butyl phosphinidene oxide which can be further trapped using water

Marine mercury pollution (2,453 words) [view diff] exact match in snippet view article find links to article

aerosol mercuric photochemistry suggesting that it occurs through a reactive intermediate: Photo oxidation is suspected to be driven by OH. radicals and reduction

Perfluorooctanoic acid (13,084 words) [view diff] exact match in snippet view article find links to article

PFOA was the most widely used perfluorocarboxylic acid used as a reactive intermediate in the production of fluoroacrylic esters. As a salt, its dominant

Oxidative coupling of phenols (1,270 words) [view diff] exact match in snippet view article find links to article

via electron transfer or hydrogen atom abstraction. The resulting reactive intermediate can engage in downstream chemical processes which can occur via

Plumbylene (2,683 words) [view diff] case mismatch in snippet view article find links to article

In Moss, Robert A.; Platz, Matthew S.; Jones, Maitland (eds.). Reactive Intermediate Chemistry. John Wiley & Sons. pp. 651–715. doi:10.1002/0471721492

Benjamin Gung (1,151 words) [view diff] exact match in snippet view article find links to article

cycloaddition reaction with gold-stabilized allylic carbocations as reactive intermediate. Gung, B. W. (1996). Diastereofacial selection in nucleophilic additions

L-Photo-methionine (2,542 words) [view diff] exact match in snippet view article find links to article

light, nitrogen leaves as nitrogen gas (N2) and forms the highly reactive intermediate carbene. Photo-activation of amino acids provide the ability of

4-Ipomeanol (3,270 words) [view diff] exact match in snippet view article find links to article

certain enzymes in their kidney which can transform 4-IPO into its reactive intermediate. As a result, renal toxicity is observed. Female mice and immature

Germanium(II) dicationic complexes (2,255 words) [view diff] case mismatch in snippet view article

S2CID 206515081. Lambert, J. B. (2008-11-28). "CHEMISTRY: A Tamed Reactive Intermediate". Science. 322 (5906): 1333–1334. doi:10.1126/science.1167321. ISSN 0036-8075

Reverse phase protein lysate microarray (2,921 words) [view diff] exact match in snippet view article find links to article

immobilized horseradish peroxidase (HRP) converts tyramide into reactive intermediate in the presence of hydrogen peroxide. Activated tyramide binds to

Müllerian anomalies (4,979 words) [view diff] exact match in snippet view article find links to article

absorbed, DES is broken down to produce a transient quinone-like reactive intermediate that alters normal gene function of HOX and WNT, affecting differentiation

Urinary anti-infective agent (3,671 words) [view diff] exact match in snippet view article find links to article

explored. When nitrofurantoin is metabolized, it converts into a reactive intermediate that attacks bacterial ribosomes, inhibiting bacterial protein synthesis