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Longer titles found: Polyketide synthase (view), Polyketide synthesis cyclase family (view)

searching for Polyketide 160 found (396 total)

alternate case: polyketide

Brevetoxin (3,214 words) [view diff] exact match in snippet view article find links to article

backbone structure of polyketides, but there are several methyl and oxygen groups that are not typical of a traditional polyketide synthesis. Labelling

Lichen product (1,083 words) [view diff] exact match in snippet view article find links to article

biochemically synthesized via the acetyl-polymalonyl pathway (also known as polyketide pathway), while only a few originate from the mevalonate and shikimate

Rajesh Sudhir Gokhale (361 words) [view diff] exact match in snippet view article find links to article

elucidation of biochemical crosstalk between fatty acid synthases and polyketide synthases in Mycobacterium tuberculosis. He holds US and Indian patents

Atrop-abyssomicin C (849 words) [view diff] exact match in snippet view article find links to article

Atrop-abyssomicin C is a polycyclic polyketide-type natural product that is the atropisomer of abyssomicin C. It is a spirotetronate that belongs to the

Sterigmatocystin (1,139 words) [view diff] exact match in snippet view article find links to article

Sterigmatocystin is a polyketide mycotoxin produced by certain species of Aspergillus. The toxin is naturally found in some cheeses. Sterigmatocystin is

Joan W. Bennett (441 words) [view diff] exact match in snippet view article find links to article

New Orleans, Louisiana. This research provided a useful model for other polyketide secondary metabolites and expanded the possibilities for reducing these

Crotonyl-CoA (299 words) [view diff] exact match in snippet view article find links to article

reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units". Nature Communications. 7: 13609. Bibcode:2016NatCo

3,5,7-Trioxododecanoyl-CoA synthase (187 words) [view diff] exact match in snippet view article find links to article

\rightleftharpoons } 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway

Gingerol (2,832 words) [view diff] exact match in snippet view article find links to article

suspected to utilize phenylpropanoid pathway and produce putative type III polyketide synthase products based on the research of 6-gingerol biosynthesis by

Anthraquinones (891 words) [view diff] exact match in snippet view article find links to article

rhubarb, and cascara buckthorn, fungi, lichens, and some insects. A type II polyketide synthase is responsible for anthraquinone biosynthesis in the bacterium

Aminoshikimate pathway (407 words) [view diff] exact match in snippet view article find links to article

Its end product, 3-amino-5-hydroxybenzoate, serves as an initiator for polyketide synthases in the biosynthesis of ansamycins. Floss and coworkers identified

Mycotoxicology (2,586 words) [view diff] exact match in snippet view article find links to article

lactones, coumarins); biochemists according to their biosynthetic origins (polyketides, amino acid-derived, etc.); physicians by the illnesses they cause (e

Curcumin synthase (1,624 words) [view diff] exact match in snippet view article find links to article

synthase categorizes three enzyme isoforms (CURS1, 2, and 3), type III polyketide synthases (PKSs) present in the leaves and rhizome of the turmeric plant

Phenolic lipid (236 words) [view diff] exact match in snippet view article find links to article

membrane-disturbing properties. The phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii. Lipid

Ascofuranone (558 words) [view diff] exact match in snippet view article find links to article

synthesized. Compound (1), ilicicolinic acid B, was found to be produced from polyketide synthase (PKS) StBA and that AscCABD are responsible for the biosynthesis

DTDP-4-dehydrorhamnose reductase (221 words) [view diff] exact match in snippet view article find links to article

pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis. As of late 2007, 5 structures have been solved

Anhydrotetracycline monooxygenase (160 words) [view diff] exact match in snippet view article find links to article

participates in tetracycline biosynthesis and biosynthesis of type ii polyketide products. Behal V (1987). "The tetracycline fermentation and its regulation"

Anthony Barrett (2,203 words) [view diff] exact match in snippet view article find links to article

"Synthesis of Macrosporin and Related 9,10-Anthraquinones by Biomimetic Polyketide Aromatization and Cyclization of 6-Benzylresorcylates". European Journal

DTDP-4-dehydro-6-deoxyglucose reductase (172 words) [view diff] exact match in snippet view article find links to article

called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis. Yoshida Y, Nakano Y, Nezu T, Yamashita Y, Koga

Lovastatin (3,305 words) [view diff] exact match in snippet view article find links to article

cholesterol. In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk

DTDP-4-dehydrorhamnose 3,5-epimerase (481 words) [view diff] exact match in snippet view article find links to article

pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis. The crystal structure of RmlC from Methanobacterium

Sesquiterpene (706 words) [view diff] exact match in snippet view article find links to article

McIntyre, C.; Scott, Fiona E.; Sadler, Ian H. (1997-03-17). "Biosynthesis of polyketide-terpenoid (meroterpenoid) metabolites andibenin B and andilesin A in Aspergillus

Amphidinium (403 words) [view diff] exact match in snippet view article find links to article

Brett A. (4 June 2012). "Genetic Diversity, Morphological Uniformity and Polyketide Production in Dinoflagellates (Amphidinium, Dinoflagellata)". PLOS ONE

Bryostatin (1,532 words) [view diff] exact match in snippet view article find links to article

B. Neritina, bryostatin biosynthesis is carried out through a type I polyketide synthase cluster, bry. BryR is the secondary metabolism homolog of HMG-CoA

Streptomyces isolates (1,666 words) [view diff] exact match in snippet view article find links to article

Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemycin Polyketide Analogues". Metabolomics Tools for Natural Product Discovery. Methods

Streptomyces glaucescens (484 words) [view diff] exact match in snippet view article find links to article

Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides". Journal of the American

Yi Tang (biochemist) (572 words) [view diff] exact match in snippet view article

synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis". Journal of the American

Kerria lacca (1,192 words) [view diff] exact match in snippet view article find links to article

anticancer effects. It is proposed that lac insects employ polyketide pathway catalysed by polyketide synthase to produce laccaic acid D, a common precursor

Tricin (350 words) [view diff] exact match in snippet view article find links to article

biosynthesizing tricin, there is first stepwise addition of malonyl CoA via the polyketide pathway and p-coumaroyl Coa via the phenylpropanoid pathway. These additions

Karine Auclair (295 words) [view diff] exact match in snippet view article find links to article

Vederas, John C.; Hutchinson, C. Richard (21 May 1999). "Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis"

David Hopwood (795 words) [view diff] exact match in snippet view article find links to article

A3(2), and for developing the programming of the pervasive process of polyketide synthesis". In 2002, he co-authored the sequencing of the S. coelicolor

Isomigrastatin (401 words) [view diff] exact match in snippet view article find links to article

oxidative deselenation. In terms of natural product, isomigrastatin is the polyketide that contains the glutarimide. Biosynthesis of isomigrastatin starts with

Prosolanapyrone-III cycloisomerase (220 words) [view diff] exact match in snippet view article find links to article

"Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani"

Polymyxin (1,443 words) [view diff] exact match in snippet view article find links to article

PMID 12569104. Kopp F, Marahiel MA (August 2007). "Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis". Natural Product Reports. 24 (4):

Streptomyces spiroverticillatus (421 words) [view diff] exact match in snippet view article find links to article

spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis". Journal of Biological Chemistry. 283 (42): 28607–28617

Diarylheptanoid (537 words) [view diff] exact match in snippet view article find links to article

Schierhorn, A; Svatos, A; Schröder, J; Schneider, B (2006). "A type III polyketide synthase from Wachendorfia thyrsiflora and its role in diarylheptanoid

Streptomyces platensis (530 words) [view diff] exact match in snippet view article find links to article

congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424

Armillaria mellea (2,894 words) [view diff] exact match in snippet view article find links to article

orsellinic acid and protoilludane sesquiterpene alcohols via esterification. A polyketide synthase gene, termed ArmB, was identified in the genome of the fungus

Mirabamide (313 words) [view diff] exact match in snippet view article find links to article

between the C-terminus and a 𝛽-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. Mirabamide G is a fusion

Peptide bond (1,388 words) [view diff] exact match in snippet view article find links to article

Biology of Nonribosomal Peptide Synthetases". Nonribosomal Peptide and Polyketide Biosynthesis. Methods in Molecular Biology. Vol. 1401. pp. 3–29. doi:10

Penicillium multicolor (561 words) [view diff] exact match in snippet view article find links to article

S. E.; Vederas, J. C. (1987). "Biosynthesis of multicolosic acid, a polyketide metabolite from Penicillium multicolor: Occurrence of large 18O-induced

Total mycosynthesis (324 words) [view diff] exact match in snippet view article find links to article

"Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite". Journal of the American

Tyrocidine (1,349 words) [view diff] exact match in snippet view article find links to article

PMID 10590309. Kopp F, Marahiel MA (August 2007). "Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis". Nat Prod Rep. 24 (4): 735–49.

Cyclopiazonic acid (1,258 words) [view diff] exact match in snippet view article find links to article

CpaS is the first enzyme in the biosynthetic pathway and is a hybrid polyketide synthase- nonribosomal peptide synthetase (PKS-NRPS). It uses the precursors

Flavan-3-ol (1,905 words) [view diff] exact match in snippet view article find links to article

4-hydroxycinnamoyl-CoA with three molecules of malonyl-CoA gives initially a polyketide (Figure 1), which can be folded. These allow Claisen-like reactions to

Flavones (976 words) [view diff] exact match in snippet view article find links to article

(1999). "Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis". Nat. Struct. Biol. 6 (8): 775–784. doi:10.1038/11553. PMID 10426957

Streptomyces arenae (502 words) [view diff] exact match in snippet view article find links to article

from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes". Gene. 227 (2): 125–35. doi:10.1016/s0378-1119(98)00618-0

Streptomyces nodosus (212 words) [view diff] exact match in snippet view article find links to article

"Amphotericin biosynthesis in Streptomyces nodosus: Deductions from analysis of polyketide synthase and late genes". Chemistry & Biology. 8 (7): 713–723. doi:10

Conformation–activity relationship (273 words) [view diff] exact match in snippet view article find links to article

A; Myles, DC; Zhou, Y (2003). "Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone

Flavan-3-ol (1,905 words) [view diff] exact match in snippet view article find links to article

4-hydroxycinnamoyl-CoA with three molecules of malonyl-CoA gives initially a polyketide (Figure 1), which can be folded. These allow Claisen-like reactions to

Daptomycin (3,758 words) [view diff] exact match in snippet view article find links to article

Fischbach MA, Walsh CT (August 2006). "Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms"

Antimycin (486 words) [view diff] exact match in snippet view article find links to article

Antimycins are produced by a non-ribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) assembly complex which acts as an assembly line for antimycin

C24H32O6 (69 words) [view diff] exact match in snippet view article find links to article

hormone Methylprednisolone acetate, a corticosteroid Verrucosidin, a fungal polyketide This set index page lists chemical structure articles associated with

L-threo-3-Methylaspartate (119 words) [view diff] exact match in snippet view article find links to article

Mutase in the Biosynthesis of the Unique Starter Unit of the Macrolactam Polyketide Antibiotic Vicenistatin". The Journal of Antibiotics. 58 (7): 468–72.

Organoaluminium chemistry (1,739 words) [view diff] exact match in snippet view article find links to article

trisubstituted olefin fragments, a common substructure in terpene and polyketide natural products. The synthesis of (E)-4-iodo-3-methylbut-3-en-1-ol shown

Dynemicin A (1,155 words) [view diff] exact match in snippet view article find links to article

biosynthesis of the dynemicin enediyne core to be catalyzed by an enediyne polyketide synthase (PKSE) similar to that employed in calicheamicin biosynthesis

C15H10O6 (90 words) [view diff] exact match in snippet view article find links to article

refer to: Asphodelin A, a coumarin Aureusidin, an aurone Citreorosein, a polyketide Fisetin, a flavonol Kaempferol, a flavonol Isoscutellarein, a tetrahydroxyflavone

Streptomyces tsukubensis (316 words) [view diff] exact match in snippet view article find links to article

Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination

Blue budgerigar mutation (1,020 words) [view diff] exact match in snippet view article find links to article

maps to a single amino acid substitution (R644W) in an uncharacterized polyketide synthase (MuPKS) gene. When the MuPKS gene is expressed in yeast, yellow

Elusimicrobium minutum (331 words) [view diff] exact match in snippet view article find links to article

seems to encode 60 PilE genes putatively involved in pilus assembly, polyketide synthesis, non-ribosomal peptide synthesis and many other still undiscovered

Sarah O'Connor (571 words) [view diff] exact match in snippet view article find links to article

Epothilones: The EpoC Subunit and Reconstitution of the EpoA-ACP/B/C Polyketide and Nonribosomal Peptide Interfaces". Biochemistry. 41 (17): 5685–5694

Phytotoxin (1,040 words) [view diff] exact match in snippet view article find links to article

phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Microbiology and Molecular Biology Reviews 63, 266-292 Tourte

Aspergillus glaucus (1,426 words) [view diff] exact match in snippet view article find links to article

marine-derived fungus Aspergillus glaucus for the production of anti-cancer polyketide". Marine Biotechnology. 14 (6): 665–71. Bibcode:2012MarBt..14..665C. doi:10

Synthon (810 words) [view diff] exact match in snippet view article find links to article

"Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster". PNAS. 101 (44): 15573–15578. Bibcode:2004PNAS

Streptomyces galbus (716 words) [view diff] exact match in snippet view article find links to article

Yeon-Ki; Kwon, Hyung-Jin (12 December 2014). "A Single Module Type I Polyketide Synthase Directs Macrolactone Biogenesis during Galbonolide Biosynthesis

Cercosporin (670 words) [view diff] exact match in snippet view article find links to article

factors in the production of cercosporin. Cercosporin is biosynthesized via polyketide synthases, and there are several genes that have been found responsible

Myriapora truncata (272 words) [view diff] exact match in snippet view article find links to article

predicted in the next 200 years. Myriapora truncata is the source of 4 polyketide-derived metabolites: Myriaprones 1-4 Wikimedia Commons has media related

Coniine (3,314 words) [view diff] exact match in snippet view article find links to article

Originally thought to use 4 acetyl groups as feed compounds for the polyketide synthase that forms coniine, it is in fact derived from two malonyl and

A23187 (559 words) [view diff] exact match in snippet view article find links to article

for the biosynthesis of the α-ketopyrrole moiety, 5 for modular type I polyketide synthases for the spiroketal ring, 4 for the biosynthesis of 3-hydroxyanthranilic

Vicenistatin (108 words) [view diff] exact match in snippet view article find links to article

mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin". The Journal of Antibiotics. 58 (7): 468–72.

Griseofulvin (961 words) [view diff] exact match in snippet view article find links to article

the synthesis of the 14-carbon poly-β-keto chain by a type I iterative polyketide synthase (PKS) via iterative addition of 6 malonyl-CoA to an acyl-CoA

6-Methylsalicylic acid (114 words) [view diff] exact match in snippet view article find links to article

acid 3-Methylsalicylic acid Staunton, James; Weissman, Kira J. (2001). "Polyketide Biosynthesis: A Millennium Review". Natural Product Reports. 18 (4): 380–416

Kibdelosporangium (270 words) [view diff] exact match in snippet view article find links to article

Actinobacterium Kibdelosporangium sp. MJ126-NF4, Producer of Type II Polyketide Azicemicins, Using Illumina and PacBio Technologies". Genome Announcements

Streptomyces lydicamycinicus (108 words) [view diff] exact match in snippet view article find links to article

sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds". Microorganisms. 8 (3): 370. doi:10

2,4-Diacetylphloroglucinol (513 words) [view diff] exact match in snippet view article find links to article

"Identification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas fluorescens Q2-87"

Plakoridine A (160 words) [view diff] exact match in snippet view article find links to article

"Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges". Natural Product Reports. 33 (7): 861–880

Penicillium chrysogenum (1,409 words) [view diff] exact match in snippet view article find links to article

Bovenberg RA, Vreeken RJ, Driessen AJ (July 2016). "Identification of a Polyketide Synthase Involved in Sorbicillin Biosynthesis by Penicillium chrysogenum"

C-1027 (1,181 words) [view diff] exact match in snippet view article find links to article

two triple bonds, and their biosynthesis is distinct from other known polyketide and fatty-acid synthesis paradigms. The enediyne PKS, PKSE, from S.

Duclauxin (175 words) [view diff] exact match in snippet view article find links to article

Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide". Journal of the American Chemical Society. 140 (22): 6991–6997. doi:10

Penicillium brefeldianum (290 words) [view diff] exact match in snippet view article find links to article

K.; Laue, E. D.; Staunton, J. (1988). "Biosynthesis of palitantin, a polyketide metabolite of Penicillium brefeldianum: 13C n.m.r. Assignment and incorporation

Józef R. Lewandowski (311 words) [view diff] exact match in snippet view article find links to article

Acyl Carrier Protein-Ketoreductase Interaction in trans-Acyltransferase Polyketide Synthases (with Munro Passmore, Angelo Gallo and Matthew Jenner, 2021)

Stahl oxidation (2,216 words) [view diff] exact match in snippet view article find links to article

Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C—H Functionalization". Journal of the American

Phloroglucinol (1,959 words) [view diff] exact match in snippet view article find links to article

fluorescens, biosynthesis of phloroglucinol is performed with a type III polyketide synthase. The synthesis begins with the condensation of three malonyl-CoAs

MTBVAC (1,464 words) [view diff] exact match in snippet view article find links to article

virulence genes regulated by PhoP are involved in biosynthesis of the polyketide-derived acyltrehaloses (DAT, PAT) and sulfolipids (SL), which are front-line

Jamaicamide A (488 words) [view diff] exact match in snippet view article find links to article

predicted that jamaicamide A's biosynthetic pathways are from a hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) assembly units. Jamaicamide

Gary Keck (248 words) [view diff] exact match in snippet view article find links to article

and the use of allylic stannanes for the stereocontrolled synthesis of polyketide chains. Throughout his career, he pursued the total synthesis of complex

Pederin (602 words) [view diff] exact match in snippet view article find links to article

Paederus Beetle Archived 2011-06-09 at the Wayback Machine Piel J (2002). "A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial

3-Ethylphenol (224 words) [view diff] exact match in snippet view article find links to article

Julia; Grininger, Martin; Boles, Eckhard (2020). "Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and

Tropinone (1,032 words) [view diff] exact match in snippet view article find links to article

AD, D'Auria JC, Barry CS (2018). "Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization". Nature Communications. 9 (1):

Center for Pharmaceutical Research and Innovation (596 words) [view diff] exact match in snippet view article find links to article

Kharel, MK; Thorson, JS (Jan 17, 2014). "Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15". Organic Letters. 16 (2): 456–9. doi:10

Mycale hentscheli (185 words) [view diff] exact match in snippet view article find links to article

microbiota. Examples of these molecules include the potent cytotoxic polyketides: pateamine, peloruside, and mycalamide. Rust, Michael; Helfrich, Eric

Prosolanapyrone-II oxidase (224 words) [view diff] exact match in snippet view article find links to article

"Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani"

Paederus (1,305 words) [view diff] exact match in snippet view article find links to article

accumulated in the eggs of most Paederus females Piel, Jörn (2002). "A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial

Satoshi Ōmura (1,804 words) [view diff] exact match in snippet view article find links to article

August 1999). "Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis". Proceedings

Rapidithrix (334 words) [view diff] exact match in snippet view article find links to article

Akira; Shizuri, Yoshikazu (June 2008). "Ariakemicins A and B, Novel Polyketide-peptide Antibiotics from a Marine Gliding Bacterium of the Genus Rapidithrix"

Orsellinaldehyde (359 words) [view diff] exact match in snippet view article find links to article

Wang, Clay C. C. (16 May 2012). "Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans". Journal of the American Chemical Society

Penicillium turbatum (214 words) [view diff] exact match in snippet view article find links to article

dehydrocurvularin by Alternaria cinerariae: Comparison of stereochemistry of polyketide and fatty acid enoyl thiol ester reductases". Journal of the American

Penicillium freii (200 words) [view diff] exact match in snippet view article find links to article

gene that is highly similar to the beta-keto-acyl synthase domain of polyketide synthase genes from other fungi". Letters in Applied Microbiology. 25

Alkylresorcinol (1,867 words) [view diff] exact match in snippet view article find links to article

Hirata, A.; Horinouchi, S. (2006). "Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii".

Karl Hult (187 words) [view diff] exact match in snippet view article find links to article

mannitol cycle, a new concept in fungal metabolism, and its relation to polyketide formation in Alternaria alternata". LIBRIS. Retrieved April 11, 2010.

Streptomyces (3,750 words) [view diff] exact match in snippet view article find links to article

"Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence". Molecular & General Genetics

Penicillium minioluteum (457 words) [view diff] exact match in snippet view article find links to article

Kito K, Yoshida S, Kanoh K, Shizuri Y, Kusumi T (March 2008). "Three new polyketide-terpenoid hybrids from Penicillium sp". Organic Letters. 10 (5): 845–8

Marinone (448 words) [view diff] exact match in snippet view article find links to article

followed by the aromatization of the resulting pentaketide using a type III polyketide synthase. Next, THN undergoes geranylation or farnesylation at the C-4

Sorangium cellulosum (788 words) [view diff] exact match in snippet view article find links to article

J.M.; Molnar, I. (2004). "Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosumvSo ce26 in Streptomyces

Post-translational modification (3,189 words) [view diff] exact match in snippet view article find links to article

of a 4'-phosphopantetheinyl moiety from coenzyme A, as in fatty acid, polyketide, non-ribosomal peptide and leucine biosynthesis retinylidene Schiff base

Penicillium raistrickii (399 words) [view diff] exact match in snippet view article find links to article

Gloer, J. B.; Wicklow, D. T.; Dowd, P. F. (1998). "New p-terphenyl and polyketide metabolites from the sclerotia of Penicillium raistrickii". Journal of

DTDP-glucose 4,6-dehydratase (565 words) [view diff] exact match in snippet view article find links to article

metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, polyketide sugar unit biosynthesis, and biosynthesis of vancomycin group antibiotics

Didemnin (681 words) [view diff] exact match in snippet view article find links to article

depsipeptide Didemnin is governed by a hybrid non-ribosomal peptide synthetase-polyketide synthetase (NRPS-PKS) pathway. The didemnin mega-synthetase consists of

Friedrich Wilhelm Zopf (979 words) [view diff] exact match in snippet view article find links to article

"Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimate metabolite production, and PKS genes". Natural Product Reports

Streptomyces himastatinicus (235 words) [view diff] exact match in snippet view article find links to article

"Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation". Organic Letters. 15 (6): 1278–1281. doi:10

Streptomyces pulveraceus (384 words) [view diff] exact match in snippet view article find links to article

Qiu, Rong-guo; Tang, Li (26 April 2013). "Identification of the Post-Polyketide Synthase Modification Enzymes for Fostriecin Biosynthesis in". Journal

Serpula lacrymans (1,102 words) [view diff] exact match in snippet view article find links to article

number of 13805 genes. The S. lacrymans genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal peptide synthetases (NPS1-NPS4

Pyrrole (3,142 words) [view diff] exact match in snippet view article find links to article

through FAD+ to yield pyrrole ring A. Ring A is then expanded via the polyketide synthase pathway to incorporate L-serine into ring B (figure 3). Ring

Tsukamurella pulmonis (626 words) [view diff] exact match in snippet view article find links to article

Onaka, Hiroyasu (2010-08-06). "Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp". Organic Letters

Penicillium verruculosum (810 words) [view diff] exact match in snippet view article find links to article

A; Ahmad, S; Ali, N (2014). "Penicillium verruculosum SG: A source of polyketide and bioactive compounds with varying cytotoxic activities against normal

Mycolicibacter (622 words) [view diff] exact match in snippet view article find links to article

polymerase, amidohydrolase, carboxymunconolacton decarboxylase family protein, polyketide cyclase, spirocyclase AveC family protein, TobH protein, UDP-N-acetylmuramate–L-alanine

Prodigiosin (1,405 words) [view diff] exact match in snippet view article find links to article

the enzyme pigA performs the oxidation. Ring A is then expanded via the polyketide synthase pathway to incorporate L-serine into ring B (figure 3). Ring

Acid mine drainage (4,551 words) [view diff] exact match in snippet view article find links to article

-G.; Kharel, M.K.; Thorson, J.S. (2014). "Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15". Org. Lett. 16 (2): 456–459. doi:10.1021/ol4033418

Debromomarinone (429 words) [view diff] exact match in snippet view article find links to article

followed by the aromatization of the resulting pentaketide using a type III polyketide synthase. Next, THN undergoes geranylation or farnesylation at the C-4

Discodermia dissoluta (483 words) [view diff] exact match in snippet view article find links to article

the scientific community due to its production of (+)-discodermolide, a polyketide natural product with potent anticancer and immunosuppressive properties

Streptomyces caelestis (442 words) [view diff] exact match in snippet view article find links to article

(December 1997). "Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis". Journal of Bacteriology.

Streptomyces ambofaciens (461 words) [view diff] exact match in snippet view article find links to article

of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens". Proceedings of the National Academy

Streptomyces tendae (510 words) [view diff] exact match in snippet view article find links to article

Möllmann, U; Gräfe, U; Hertweck, C (19 September 2005). "Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance"

Doxorubicin (4,385 words) [view diff] exact match in snippet view article find links to article

"Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase". Gene. 151 (1–2): 1–10. doi:10.1016/0378-1119(94)90625-4. PMID 7828855

Alamethicin (721 words) [view diff] exact match in snippet view article find links to article

; Walsh, Christopher T. (August 2006). "Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms"

Pseudomonas cichorii (1,771 words) [view diff] exact match in snippet view article find links to article

Phytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases". Microbiology and Molecular Biology Reviews. 63 (2): 266–292

Anatoxin-a (4,930 words) [view diff] exact match in snippet view article find links to article

Homoanatoxin-a in the Cyanobacterium Oscillatoria PCC 6506 Occurs on a Modular Polyketide Synthase Initiated by l-Proline". Journal of the American Chemical Society

Streptomyces halstedii (806 words) [view diff] exact match in snippet view article find links to article

(January 2006). "The Complete Biosynthetic Gene Cluster of the 28-Membered Polyketide Macrolactones, Halstoctacosanolides, from Streptomyces halstedii HC34"

Michael J. Krische (880 words) [view diff] exact match in snippet view article find links to article

Michael J. (2016). "Enantioselective Alcohol C–H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical

Halichondrin B (648 words) [view diff] exact match in snippet view article find links to article

Wagoner, Ryan M.; Satake, Masayuki; Wright, Jeffrey L. C. (2014-06-16). "Polyketide biosynthesis in dinoflagellates: what makes it different?". Natural Product

Hentriacontanonaene (547 words) [view diff] exact match in snippet view article find links to article

of two 16:4(n-3) acyl chains by OleABCD yields hentriacontanonaene. A polyketide-like pathway responsible for the production of eicosapentaenoic acid provides

Pretenellin A (270 words) [view diff] exact match in snippet view article find links to article

(2011-07-20). "Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase". Journal of the American Chemical Society. 133 (28): 10990–10998

Mycobacterium leprae (5,277 words) [view diff] exact match in snippet view article find links to article

which plays an important role in both Nucleotide sugar metabolism and polyketide sugar unit biosynthesis. Petidoglycan biosynthesis also require murG,

Hydrogen auto-transfer (1,574 words) [view diff] exact match in snippet view article find links to article

via Transfer Hydrogenative Allylation, Crotylation, and Propargylation: Polyketide Construction beyond Discrete Allyl- or Allenylmetal Reagents". Journal

Constipatic acid (657 words) [view diff] exact match in snippet view article find links to article

Lichen-Forming Fungi: Lichen Substances, Chemosyndromic Variation and Origin of Polyketide-Type Metabolites (Biosynthetic Pathways)". In Upreti, Dalip Kumar; Divakar

Anthochlor pigments (861 words) [view diff] exact match in snippet view article find links to article

reductase (CHR) and NADPH as a co-factor, the oxygen function of the polyketide intermediate is reduced and eliminated as water prior to cyclization,

Alison R. H. Narayan (1,075 words) [view diff] exact match in snippet view article find links to article

Hinze, M. E.; Skiba, M. A.; Narayan, A. R. H. "Chemistry of a unique polyketide-like synthase" J. Am. Chem. Soc. 2018, 140, 2430–2433. doi:10.1021/jacs

Lydicamycin (324 words) [view diff] exact match in snippet view article find links to article

sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds". Microorganisms. 8 (3): 370. doi:10

Combinatorial chemistry (6,742 words) [view diff] exact match in snippet view article find links to article

JS "Stereochemical diversity through cyclodimerization: Synthesis of polyketide-like macrodiolides." Org Lett 2003, 5:2149-2152. Medina-Franco, J.L.;

Exodermis (2,664 words) [view diff] exact match in snippet view article find links to article

cloning, functional expression, and site-directed mutagenesis of two polyketide synthases". The Plant Journal. 34 (6): 847–855. doi:10.1046/j.1365-313X

Ramalina americana (811 words) [view diff] exact match in snippet view article find links to article

(2012). "Monophyly of some North American species of Ramalina and inferred polyketide synthase gene function". Botany. 90 (12): 1295–1307. doi:10.1139/b2012-097

Marine pharmacognosy (1,829 words) [view diff] exact match in snippet view article find links to article

N/A Sponge Tripeptide Microtubules 0/3 Cancer Bryostatin 1 N/A Bryozoa Polyketide Protein Kinase C 0/38 Cancer, Alzheimers Pseudopterosins N/A Soft Coral

Azotobacter (4,687 words) [view diff] exact match in snippet view article find links to article

Hirata A.; Horinouchi S. (2006). "Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii".

Tabtoxin (1,045 words) [view diff] exact match in snippet view article find links to article

Phytotoxins: Mode of Action, Regulation, and Biosynthesis by Peptide and Polyketide Synthetases". Microbiol. Mol. Biol. Rev. 63 (2): 266–292. doi:10.1128/MMBR

Rup Lal (466 words) [view diff] exact match in snippet view article find links to article

Kumari, Rashmi; Singh, Priya (2014-07-25). "Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistant

Joseph Jez (875 words) [view diff] exact match in snippet view article find links to article

where he studied the structure, mechanisms, and engineering of plant polyketide biosynthesis. He worked at Kosan Biosciences from 2001 to 2002, before

Halovir (1,968 words) [view diff] exact match in snippet view article find links to article

Joshawna K.; Powell, David H.; Butcher, Rebecca A. (October 2016). "A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival". Nature

(acyl-carrier-protein) S-malonyltransferase (1,692 words) [view diff] exact match in snippet view article

pathway. However, in Streptomyces coelicolor, FabD is involved in FAS and polyketide synthase pathways. In both cases, the structures and active sites are

Heinz Falk (4,001 words) [view diff] exact match in snippet view article find links to article

Wolkenstein, H. Sun, C. Griesinger, H. Falk: Exceptional preservation of polyketide secondary metabolites in macrofossils. Abstr. 27th Intern. Meeting on

Timeline of United States discoveries (13,821 words) [view diff] exact match in snippet view article find links to article

Cleveland Clinic. 1948 Tetracycline Tetracycline is a broad-spectrum polyketide antibiotic indicated for use against many bacterial infections. It is

Naturally occurring phenols (7,807 words) [view diff] exact match in snippet view article find links to article

the phenyl propanoid derivatives (C6–C3); (ii) the acetate/malonate or polyketide pathway, which produces the side-chain-elongated phenyl propanoids, including

Orange carotenoid protein (2,907 words) [view diff] exact match in snippet view article find links to article

proteins with functions as diverse as limonene-1,2-epoxide hydrolase, SnoaL polyketide cyclase, and delta-5-3-ketosteroid isomerase (KSI). Most, if not all,

Exometabolomics (2,091 words) [view diff] exact match in snippet view article find links to article

Ten, L. N.; Mukhamedzhanov, S. Z.; Dzhavakhiya, V. G. (1988-07-01). "Polyketide exometabolites of the causative agent of rice blast and their role in

Chaetomium cupreum (2,473 words) [view diff] exact match in snippet view article find links to article

Chaetomium cupreum produces a range of antifungal metabolites including polyketide synthase, terpenes, chetomin, rotiorinols A-C, "multidrug resistance protein"

Lyngbyastatins (506 words) [view diff] exact match in snippet view article find links to article

encoded for by a 52 kb biosynthetic gene cluster (BGC) containing one polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS) hybrid (LbnA),

Kedarcidin (2,705 words) [view diff] exact match in snippet view article find links to article

enediyne core of these molecules is initiated by a common enzyme, enediyne polyketide synthase (PKS). The polyene product of this enzyme is then divergently

Alexandrium (dinoflagellate) (4,817 words) [view diff] exact match in snippet view article

and spirolides are produced in the G2 phase of the cell cycle. Specific polyketide (PKS) genes are involved in spirolide biosynthesis. Spirolide is composed

Morpheein (6,781 words) [view diff] exact match in snippet view article find links to article

Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product". Molecular Cell. 16 (6): 881–91. doi:10.1016/j.molcel

Coicenal (690 words) [view diff] exact match in snippet view article find links to article

March 2023. Thanabalasingam, D (March 27, 2023). "Oryzanigral: a new polyketide from an endophytic fungus Nigrospora oryzae isolated from Coccinia grandis"

Arne Jørgen Aasen (1,406 words) [view diff] exact match in snippet view article find links to article

B. A., Aasen, A. J. and Robeson, D. J., Studies on the Mechanism of Polyketide-derived Biosynthesis of Deoxyradicinin and Related Metabolites of Alternaria