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searching for Mitotic exit 38 found (43 total)

Biochemical switches in the cell cycle (6,678 words) [view diff] exact match in snippet view article find links to article

triggering irreversible mitotic exit. Clb2 degradation did shorten the Cdk1-inhibition period required for triggering irreversible mitotic exit indicating that

Cdc14 (2,752 words) [view diff] exact match in snippet view article find links to article

understood and most-studied, the activity of Cdc14 (ScCdc14) leads to mitotic exit by dephosphorylating targets of Cdk1, a well-studied cyclin-dependent

Telophase (2,667 words) [view diff] exact match in snippet view article find links to article

seen in budding yeast, which do not have redundant phosphatases for mitotic exit and rely on the phosphatase cdc14. Blocking cdc14 activation in these

Polo-like kinase (1,508 words) [view diff] exact match in snippet view article find links to article

serine/threonine kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. Only one Plk is found in

BUB3 (2,197 words) [view diff] exact match in snippet view article find links to article

Anaphase Promoting Complex (APC), preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation

CellCognition (515 words) [view diff] exact match in snippet view article find links to article

imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells". Nature Cell Biology. 12 (9): 886–93. doi:10

H3S10P (2,389 words) [view diff] exact match in snippet view article find links to article

increases during mitosis while H3K9me3 decreases and H3K9me3 recovers upon mitotic exit. R loops are linked to H3S10P and chromatin condensation. The name of

TPX2 (4,947 words) [view diff] exact match in snippet view article find links to article

regulated by the APC/CCdh1 pathway. The instability and drop in TPX2 at mitotic exit is dependent on both the anaphase-promoting complex/cyclosome (APC/C)

Anaphase-promoting complex (4,185 words) [view diff] exact match in snippet view article find links to article

extracts can prevent the destruction of endogenous cyclin A, cyclin B, and mitotic exit, suggesting that Emi1 is able to counteract the activity of the APC.

RPS6KA2 (1,058 words) [view diff] exact match in snippet view article find links to article

in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit". Cell. Signal. 13 (9): 653–64. doi:10.1016/S0898-6568(01)00185-1. PMID 11495723

CDC14B (827 words) [view diff] exact match in snippet view article find links to article

"Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Molecular and Cellular Biology. 23 (9): 3173–3185

SUMO protein (4,909 words) [view diff] case mismatch in snippet view article find links to article

the case of Tof2-Cdc14, Cdc14 release from the nucleolus allows the Mitotic Exit Network to commence, but it is regulated by the binding of Tof2, a protein

Sirtuin 2 (3,217 words) [view diff] exact match in snippet view article find links to article

"Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Molecular and Cellular Biology. 23 (9): 3173–3185

LATS1 (1,129 words) [view diff] exact match in snippet view article find links to article

S2CID 25678521. Bothos J, Tuttle RL, Ottey M, et al. (2005). "Human LATS1 is a mitotic exit network kinase". Cancer Res. 65 (15): 6568–75. doi:10.1158/0008-5472

FOXM1 (1,471 words) [view diff] exact match in snippet view article find links to article

Alvarez-Fernandez M, Stahl M, Medema RH (September 2008). "FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner". Cell Cycle. 7 (17): 2720–6. doi:10.4161/cc

Raymond J. Deshaies (2,482 words) [view diff] exact match in snippet view article find links to article

protein Net1 in late anaphase, which is triggered by the action of the mitotic exit network (MEN). In later work, they established that an early step in

Sirtuin (2,326 words) [view diff] exact match in snippet view article find links to article

"Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Molecular and Cellular Biology. 23 (9): 3173–85.

CKAP2 (818 words) [view diff] exact match in snippet view article find links to article

"CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit". J. Biol. Chem. 282 (20): 15103–13. doi:10.1074/jbc.M701688200. PMID 17376772

Rong Li (2,616 words) [view diff] exact match in snippet view article find links to article

subsequently made a number of significant discoveries in the area of mitotic exit control and cytokinesis. She is recognized as a leader in the study of

Cyclin-dependent kinase 1 (2,896 words) [view diff] exact match in snippet view article find links to article

cyclins leads to the final events of mitosis (e.g., spindle disassembly, mitotic exit). Given its essential role in cell cycle progression, Cdk1 is highly

Angelika Amon (2,312 words) [view diff] case mismatch in snippet view article find links to article

Tyers, Mike; Amon, Angelika (1998). "The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation". Molecular Cell. 2 (6):

Aurora kinase A (2,764 words) [view diff] exact match in snippet view article find links to article

remains associated with the spindles through telophase. Right before mitotic exit, Aurora A relocalizes to the mid-zone of the spindle. During mitosis

PRC1 (1,806 words) [view diff] exact match in snippet view article find links to article

and G2/M phases of the cell cycle before dropping dramatically after mitotic exit and entrance into G1 phase. PRC1 is located in the nucleus during interphase

P21 (3,978 words) [view diff] case mismatch in snippet view article find links to article

Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit". Cell. 155 (2): 369–383. doi:10.1016/j.cell.2013.08.062. PMC 4001917

BUB1B (2,313 words) [view diff] exact match in snippet view article find links to article

"Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit". The Journal of Cell Biology. 183 (4): 667–680. doi:10.1083/jcb.200805163

Alternating electric field therapy (2,465 words) [view diff] exact match in snippet view article find links to article

treating fields perturb the localization of septins and cause aberrant mitotic exit". PLOS ONE. 10 (5): e0125269. Bibcode:2015PLoSO..1025269G. doi:10.1371/journal

Mitosis (7,317 words) [view diff] exact match in snippet view article find links to article

signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit". Progress in Cell Cycle Research. 5: 431–9. PMID 14593737. FitzHarris

Cell synchronization (2,132 words) [view diff] exact match in snippet view article find links to article

including the G2/M transition, the metaphase/anaphase transition, and mitotic exit. Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization

Conly Rieder (1,545 words) [view diff] exact match in snippet view article find links to article

until each chromosome becomes attached to the spindle, and only then mitotic exit is initiated. By using a laser to ablate kinetochores on individual chromosomes

Cadherin-1 (6,380 words) [view diff] exact match in snippet view article find links to article

Alvarez-Fernandez M, Stahl M, Medema RH (September 2008). "FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner". Cell Cycle. 7 (17): 2720–6. doi:10.4161/cc

TRIP13 (1,804 words) [view diff] case mismatch in snippet view article find links to article

(May 2017). "Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit". Cell Reports. 19 (9): 1832–1845. doi:10.1016/j.celrep.2017.05.021.

Hysteresis (9,146 words) [view diff] exact match in snippet view article find links to article

higher threshold for mitotic entry compared to the lower threshold for mitotic exit indicates hysteresis, a hallmark of history-dependent behavior in the

BTRC (gene) (3,356 words) [view diff] exact match in snippet view article

anaphase-metaphase transition (by inducing the proteolysis of Securin) and mitotic exit (by driving the degradation of mitotic CDK1 activating cyclin subunits)

ANLN (2,939 words) [view diff] exact match in snippet view article find links to article

Rho-kinase. It has been observed that anillin proteolysis is triggered after mitotic exit by the Anaphase Promoting Complex (APC). Most anillins can be sequestered

Live single-cell imaging (2,213 words) [view diff] case mismatch in snippet view article find links to article

Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit". Cell. 155 (2): 369–383. doi:10.1016/j.cell.2013.08.062. PMC 4001917

FBXW11 (3,045 words) [view diff] exact match in snippet view article find links to article

anaphase-metaphase transition (by inducing the proteolysis of Securin) and mitotic exit (by driving the degradation of mitotic CDK1 activating cyclin subunits)

C8orf34 (2,314 words) [view diff] exact match in snippet view article find links to article

Hu Z, Li H, Li J (June 2017). "Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity". Scientific Reports. 7 (1): 2854. Bibcode:2017NatSR

Early Mitotic Inhibitor 1 (2,167 words) [view diff] exact match in snippet view article find links to article

the cell cycle by targeting mitotic regulators for degradation during mitotic exit. By inhibiting APC/C at the S and G2 phases of the cell cycle, EMI1 ensures