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searching for Macrocycle 78 found (157 total)

alternate case: macrocycle

Cyclic peptide (989 words) [view diff] no match in snippet view article find links to article

Cyclic peptides are polypeptide chains which contain a circular sequence of bonds. This can be through a connection between the amino and carboxyl ends

Sports periodization (2,550 words) [view diff] exact match in snippet view article find links to article

time up into three types of cycles: microcycle, mesocycle, and macrocycle. A macrocycle refers to a season of training in its entirety. It is an annual

Inherent chirality (964 words) [view diff] exact match in snippet view article find links to article

this phenomenon by suggesting that if an inherently chiral calixarene macrocycle were opened up it would produce an "achiral linear molecule". There are

Boron porphyrins (1,804 words) [view diff] exact match in snippet view article find links to article

Boron porphyrins are a variety of porphyrin, a common macrocycle used for photosensitization and metal trapping applications, that incorporate boron. The

Chelatase (249 words) [view diff] exact match in snippet view article find links to article

tight fit of the metal into the rigid 18- or 17-membered tetrapyrrole macrocycle. Several families of chelatase are known including cobalt chelatase, magnesium

Bottromycin (3,272 words) [view diff] exact match in snippet view article find links to article

the macrocycle. In this study, it was proposed that the methylated proline residue contributed to the restricted conformation of the macrocycle. The

Red chlorophyll catabolite reductase (223 words) [view diff] exact match in snippet view article find links to article

(PaO) catalyse the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of Pheide a to a primary fluorescent catabolite (pFCC). Wüthrich

Curtin–Hammett principle (3,757 words) [view diff] exact match in snippet view article find links to article

twisted 16-membered macrocycle. A key step in the syntheses is selective amide bond formation to produce the correct macrocycle. In Phil Baran's enantioselective

TMC-647055 (196 words) [view diff] exact match in snippet view article find links to article

HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055". Bioorganic & Medicinal Chemistry

Ligand (3,352 words) [view diff] exact match in snippet view article find links to article

iron atom is at the centre of a porphyrin macrocycle, bound to four nitrogen atoms of the tetrapyrrole macrocycle. The very stable dimethylglyoximate complex

Paal–Knorr synthesis (1,625 words) [view diff] exact match in snippet view article find links to article

prior to isolation. In 1982, H. Hart et al. reported a synthesis of a macrocycle containing fused furan rings using a Paal–Knorr furan synthesis. Refluxing

Ring-closing metathesis (4,704 words) [view diff] exact match in snippet view article find links to article

Siegfried Warwel and Hans Kaitker published a synthesis of symmetric macrocycles through a cross-metathesis dimerization of starting cycloolefins to afford

4+4 Photocycloaddition (917 words) [view diff] exact match in snippet view article find links to article

this reaction first forms fused rings, subsequent cleavages can afford macrocycles. In this partial synthesis of the BC rings of Taxol, the framework buildup

Stevens rearrangement (718 words) [view diff] exact match in snippet view article find links to article

Kurti, Barbara Czako Academic Press (4 March, 2005) ISBN 0-12-429785-4 Macrocycle Ring Expansion by Double Stevens RearrangementKeisha K. Ellis-Holder,

Thiostrepton (1,491 words) [view diff] exact match in snippet view article find links to article

dehydropiperidine core (2), thiazoline macrocycle (3), bis-dehydroalanine tail (4), and quinaldic acid macrocycle (5). Then they assembled the building

4+4 Photocycloaddition (917 words) [view diff] exact match in snippet view article find links to article

this reaction first forms fused rings, subsequent cleavages can afford macrocycles. In this partial synthesis of the BC rings of Taxol, the framework buildup

Robinson–Gabriel synthesis (1,009 words) [view diff] exact match in snippet view article find links to article

PMID 15469287. Zhang, J; Ciufolini, M.A. (2011). "An Approach to the Bis-oxazole Macrocycle of Diazonamides". Org. Lett. 13 (3): 390–393. doi:10.1021/ol102678j. PMID 21174393

Stapled peptide (1,723 words) [view diff] exact match in snippet view article find links to article

covalent linkage between two amino acid side-chains, forming a peptide macrocycle. Staples, generally speaking, refer to a covalent linkage of two previously

Alkyne metathesis (1,309 words) [view diff] exact match in snippet view article find links to article

Hyeon Mo Cho; Jeffrey S. Moore (2007). "Preparation of a Carbazole-Based Macrocycle via Precipitation-driven Alkyne Metathesis". Org. Synth. 84: 177. doi:10

Carbon nanotube chemistry (3,689 words) [view diff] exact match in snippet view article find links to article

nanotubes (SWNTs). In this strategy, the SWNTs are encapsulated by molecular macrocycle(s), which are either formed around them by macrocyclization, or pre-formed

Selenenic acid (761 words) [view diff] exact match in snippet view article find links to article

SeOH functional group within the cavity of a p-tert-butyl[calix[6]arene macrocycle]. X-ray crystallographic analysis revealed the Se-O bond length to be

Photodynamic therapy (9,553 words) [view diff] exact match in snippet view article find links to article

tetrapyrrolic molecules, with the heart of the skeleton a heterocyclic macrocycle, known as a porphine. The fundamental porphine frame consists of four

Molecular machine (5,807 words) [view diff] exact match in snippet view article find links to article

mechanically interlocked molecules derived from catenanes where a large macrocycle backbone connects at least three small rings in the shape of a necklace

Mycolactone (824 words) [view diff] exact match in snippet view article find links to article

Timothy L.; Wike, Candice L.; Burkart, Michael D. (2008). "The unusual macrocycle forming thioesterase of mycolactone". Molecular BioSystems. 4 (6): 663–671

Hydronium perchlorate (203 words) [view diff] exact match in snippet view article find links to article

as a chelating agent to sequester Cu(II): transmetallation of the macrocycle with copper(II) perchlorate yielded colorless crystals of hydronium perchlorate

Organomolybdenum chemistry (1,121 words) [view diff] exact match in snippet view article find links to article

Hyeon Mo Cho; Jeffrey S. Moore (2007). "Preparation of a Carbazole-Based Macrocycle via Precipitation-driven Alkyne Metathesis" (PDF). Org. Synth. 84: 177

Teixobactin (1,578 words) [view diff] exact match in snippet view article find links to article

"Selcia Scientists Elucidate Stereochemistry of Novel Antibacterial Macrocycle Teixobactin, Published in Nature". Essex, U.K.: Selcia. Retrieved 10 January

Pseudomonas denitrificans (295 words) [view diff] exact match in snippet view article find links to article

Cameron, B.; Crouzet, J.; Blanche, F. (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". Journal of Bacteriology

Insulin regulated aminopeptidase (3,679 words) [view diff] exact match in snippet view article find links to article

modifications on the AngIV-based inhibitors from Anderson et al led to optimized macrocycle HA08 (available crystal structure within IRAP, Figure 2) with excellent

Liebeskind–Srogl coupling (1,399 words) [view diff] exact match in snippet view article find links to article

employing this reaction to construct the north eastern fragment of the macrocycle and the terpene chain. The Yu lab has demonstrated that in the presence

Transmetalation (1,548 words) [view diff] exact match in snippet view article find links to article

carbonylative coupling of vinyl triflates with vinyl stannanes as the macrocycle-forming step". J. Am. Chem. Soc. 112 (23): 8465–8472. doi:10.1021/ja00179a035

Cyclic iron tetra N-heterocyclic carbenes (2,872 words) [view diff] exact match in snippet view article find links to article

in heme, cannot accept electrons from the iron center back towards the macrocycle. More electron density is donated to the iron center compared to heme

Sandwich compound (1,590 words) [view diff] exact match in snippet view article find links to article

octahedral "carbon-wired" system shown below, which contains a planar C16B8 macrocycle. In these anti-bimetallic compounds, the metals are found to be bridged

Wulff–Dötz reaction (1,503 words) [view diff] exact match in snippet view article find links to article

"Application of the Dötz Reaction to Construction of a Major Portion of the Ansa Macrocycle (−)-Kendomycin". Organic Letters. 7 (2): 235–238. doi:10.1021/ol047779s

Epothilone (2,166 words) [view diff] exact match in snippet view article find links to article

polyketide macrolactone with a methylthiazole group connected to the macrocycle by an olefinic bond. The polyketide backbone was synthesized by type I

Conotoxin (1,501 words) [view diff] exact match in snippet view article find links to article

disulfide-through-disulfide knot, in which the III-VI disulfide bond crosses the macrocycle formed by two other disulfide bonds (I-IV and II-V) and the interconnecting

CAPS (buffer) (137 words) [view diff] exact match in snippet view article

L.; Cable, Morgan L.; Gray, Harry B.; Ponce, Adrian (2010). "Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine

Ipglycermides (948 words) [view diff] exact match in snippet view article find links to article

Ipglycermides are composed of 14 amino acids and contain an 8-membered macrocycle formed through a thioether bridge connecting the D-Tyr1 α-acetamide and

Bioinorganic chemistry (2,371 words) [view diff] exact match in snippet view article find links to article

crystallographically by Dorothy Crowfoot Hodgkin to consist of a cobalt in a corrin macrocycle. Several distinct systems are of identifiable in bioinorganic chemistry

Kendomycin (333 words) [view diff] exact match in snippet view article find links to article

Synthesis of (−)-Kendomycin Featuring a Prins-Cyclization to Construct the Macrocycle". J. Am. Chem. Soc. 130 (13): 13177–81. doi:10.1021/ja805187p. PMC 2697922

Mechanically interlocked molecular architectures (1,315 words) [view diff] exact match in snippet view article find links to article

Jobe, Kajally; Watkinson, Michael; Goldup, Stephen M. (2011-04-26). "Macrocycle Size Matters: "Small" Functionalized Rotaxanes in Excellent Yield Using

Sue Gibson (chemist) (724 words) [view diff] exact match in snippet view article

ligand design, amino acid and peptide synthesis, medicinal chemistry, macrocycle synthesis, asymmetric induction, dendrimer construction, linker technology

Oxygen reduction reaction (1,225 words) [view diff] exact match in snippet view article find links to article

Miller, Jeffrey T.; Surendranath, Yogesh (2020-10-19). "A pyridinic Fe-N 4 macrocycle models the active sites in Fe/N-doped carbon electrocatalysts". Nature

Methyl 2-bromoacetate (437 words) [view diff] exact match in snippet view article find links to article

selective colorimetric anion sensor based on an amide group containing macrocycle". Chemical Communications (20): 2450–2451. doi:10.1039/b207335h. PMID 12430485

Pinnatoxin (1,668 words) [view diff] exact match in snippet view article find links to article

Shu-zhen; Chen, Hai-sheng (January 1995). "Pinnatoxin A: a toxic amphoteric macrocycle from the Okinawan bivalve Pinna muricata". Journal of the American Chemical

Plerixafor (1,685 words) [view diff] exact match in snippet view article find links to article

plerixafor is its zinc complex. Three of the four nitrogen atoms of the macrocycle cyclam... (1,4,8,11-tetraazacyclotetradecane) are protected with tosyl

Pheophorbide a oxygenase (399 words) [view diff] exact match in snippet view article find links to article

in chlorophyll breakdown in higher plants. Cleavage of pheophorbide a macrocycle by a monooxygenase". The Journal of Biological Chemistry. 273 (25): 15335–9

Precorrin-6A synthase (deacetylating) (186 words) [view diff] exact match in snippet view article

Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22):

Ferrochelatase (2,090 words) [view diff] exact match in snippet view article find links to article

investigation. Many researchers have hypothesized distortion of the porphyrin macrocycle as key to catalysis. Researchers studying Bacillus subtilis ferrochelatase

Humulene (1,748 words) [view diff] exact match in snippet view article find links to article

in the laboratory, involving differing closures of the C-C bond in the macrocycle. The McMurry synthesis uses a titanium-catalyzed carbonyl coupling reaction;

Precorrin-3B synthase (262 words) [view diff] exact match in snippet view article find links to article

Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22):

B vitamins (2,803 words) [view diff] exact match in snippet view article find links to article

some amino acids, such as glycine. Heme B is the porphyrin derivative macrocycle molecule that holds the iron atom in place in hemoglobin, allowing for

Precorrin-2 C20-methyltransferase (264 words) [view diff] exact match in snippet view article find links to article

Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22):

Linaclotide (1,633 words) [view diff] exact match in snippet view article find links to article

price of linaclotide to around $414 in 2018. Oh SA (17 August 2011). "Macrocycle Milestone for Ironwood Pharma". The Haystack. Archived from the original

Lugdunin (755 words) [view diff] exact match in snippet view article find links to article

the carbonyl on the C-terminal L-valine residue, thus forming an imine macrocycle. The Schiff base formed in this reaction is then nucleophilically attacked

Transporter Classification Database (5,159 words) [view diff] exact match in snippet view article find links to article

51 The Protein Nanopore (ProNP) Family 1.D.52 The Aromatic Oligoamide Macrocycle Nanopore (OmnNP) Family 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT)

2,4-Dinitrophenol (3,735 words) [view diff] exact match in snippet view article find links to article

Nitrophenolic Explosives by Using Nanospheres of a Tetraphenylethylene Macrocycle Displaying Aggregation-Induced Emission". Chemistry - A European Journal

Atrop-abyssomicin C (849 words) [view diff] exact match in snippet view article find links to article

that was proposed to be the reactive center. Despite being a strained macrocycle, there exist an atropisomer, abyssomicin C. The atropisomerism arise due

Metalloprotein (5,335 words) [view diff] exact match in snippet view article find links to article

to iron (Fe) in hemoglobin. Additionally, chlorophyll has an extended isoprenoid tail and an additional aliphatic cyclic structure off the macrocycle.

Persistent radical effect (705 words) [view diff] exact match in snippet view article find links to article

selectivity in a free-radical reaction involving persistent .cntdot.CoII[macrocycle] and alkyl free radicals Brian E. Daikh and Richard G. Finke Journal of

Tetrapyrazinoporphyrazine (3,463 words) [view diff] exact match in snippet view article find links to article

bands (also known as B-bands) and Q-bands, similar to their analogous macrocycles. These bands result from the extended aromatic π-conjugation, allowing

Zotiraciclib (619 words) [view diff] exact match in snippet view article find links to article

Singapore by S*BIO Pte Ltd and falls under the category of small molecule macrocycles. It crosses the blood brain barrier and acts by depleting Myc through

Stuart Rowan (815 words) [view diff] exact match in snippet view article find links to article

doubly-threaded architectures where two chains are threaded through one macrocycle. The new synthetic methodology utilizes metal-ligand coordination as the

Sagopilone (334 words) [view diff] exact match in snippet view article find links to article

derived from polyketides. Sagopilone is a 16-bond macrolide structure, a macrocycle with inner ester structure. With its C30H41NO6S formula and a molecular

Sergii Putsov (747 words) [view diff] exact match in snippet view article find links to article

the training process of highly qualified weightlifters in the annual macrocycle". He is also certified in strength sports coaching and physical education

Aza-Cope rearrangement (5,704 words) [view diff] exact match in snippet view article find links to article

iminium ions stay in close enough proximity to undergo Mannich cyclization. Macrocycle synthesis has not been reported using this reaction, due to the lack of

Cyclol (6,373 words) [view diff] exact match in snippet view article find links to article

configuration effect and the transannular intrinsic rates in bislactam macrocycles". Journal of the Chemical Society, Perkin Transactions 2. 2002 (12):

Rifaquizinone (253 words) [view diff] exact match in snippet view article find links to article

and skin structure infections. Cefilavancin Surur AS, Sun D (2021). "Macrocycle-Antibiotic Hybrids: A Path to Clinical Candidates". Frontiers in Chemistry

Molecular switch (4,652 words) [view diff] exact match in snippet view article find links to article

architectures where the bistable states differ in the position of the macrocycle. These systems enable dynamic and reversible switching between different

Kinetic isotope effect (14,026 words) [view diff] exact match in snippet view article find links to article

smaller effective size, allows easier passage of the stoppers through the macrocycle, resulting in faster deslipping for the deuterated rotaxanes. Reactions

Cytochalasin B (3,972 words) [view diff] exact match in snippet view article find links to article

an intermolecular Diels-Alder reaction and in a second step append the macrocycle in a stepwise fashion. Cytochalasin B contains several highly polar keto-

Cefilavancin (383 words) [view diff] exact match in snippet view article find links to article

1099/mic.0.001387. PMC 10569064. PMID 37656158. Surur AS, Sun D (2021). "Macrocycle-Antibiotic Hybrids: A Path to Clinical Candidates". Frontiers in Chemistry

Peucemycin (448 words) [view diff] exact match in snippet view article find links to article

terminal thioesterase domain in Module 7 catalyzes the product release and macrocycle formation to form peucemycin. Pham, Van Thuy Thi; Nguyen, Hue Thi; Nguyen

Naturally occurring phenols (7,687 words) [view diff] exact match in snippet view article find links to article

An example of such molecules is catechin. Cavicularin is an unusual macrocycle because it was the first compound isolated from nature displaying optical

Erythronolide synthase (2,979 words) [view diff] exact match in snippet view article find links to article

Chen JC, Foster PG, et al. (December 2001). "Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility

Vitamin B12 total synthesis (7,466 words) [view diff] exact match in snippet view article find links to article

vitamin B12.: 1563 At Harvard, it was shown that the closure to the corrin macrocycle could also be realized by the method of thioiminoester/enamine condensation

Vibrational spectroscopic map (3,065 words) [view diff] exact match in snippet view article find links to article

Vibrational Couplings Revealed by 2D IR Spectroscopy of an Isotopically Labeled Macrocycle: Quantitative Benchmark for the Interpretation of Amyloid and Protein

Jose Luis Mendoza-Cortes (16,837 words) [view diff] exact match in snippet view article find links to article

pinpoint stabilising contacts between the axle's stopper groups and the macrocycle, while Hirshfeld surfaces quantify ring–axle dispersive interactions.