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searching for Macrocycle 63 found (138 total)

alternate case: macrocycle

Cyclic peptide (687 words) [view diff] no match in snippet view article find links to article

Cyclic peptides are polypeptide chains which contain a circular sequence of bonds. This can be through a connection between the amino and carboxyl ends
Sports periodization (2,553 words) [view diff] exact match in snippet view article find links to article
progress. A macrocycle is an annual plan that works towards peaking for the goal competition of the year. There are three phases in the macrocycle: preparation
Dynamic covalent chemistry (1,993 words) [view diff] exact match in snippet view article find links to article
as covalent organic frameworks, molecular knots, polymers, and novel macrocycles. Not to be confused with dynamic combinatorial chemistry, DCvC concerns
Inherent chirality (1,022 words) [view diff] exact match in snippet view article find links to article
this phenomenon by suggesting that if an inherently chiral calixarene macrocycle were opened up it would produce an "achiral linear molecule". There are
Hydroxymethylbilane (181 words) [view diff] exact match in snippet view article find links to article
form a porphyrinogen a class of compounds with the hexahydroporphine macrocycle; specifically, uroporphyrinogen III. In the absence of the enzyme, the
Ossamycin (446 words) [view diff] exact match in snippet view article find links to article
6-spiroacetal (1,7-dioxaspiro[5,5]-undecanyl) moiety connected to one side of the macrocycle. Widely-studied 26-membered oligomycins/rutamycins, 24-membered dunaimycins
Boron porphyrins (1,798 words) [view diff] exact match in snippet view article find links to article
Boron porphyrins are a variety of porphyrin, a common macrocycle used for photosensitization and metal trapping applications, that incorporate boron. The
Chelatase (255 words) [view diff] exact match in snippet view article find links to article
tight fit of the metal into the rigid 18- or 17-membered tetrapyrrole macrocycle. Several families of chelatase are known including cobalt chelatase, magnesium
Red chlorophyll catabolite reductase (212 words) [view diff] exact match in snippet view article find links to article
(PaO) catalyse the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of Pheide a to a primary fluorescent catabolite (pFCC). Wüthrich
Stapled peptide (1,230 words) [view diff] exact match in snippet view article find links to article
covalent linkage between two amino acid side-chains, forming a peptide macrocycle. Staples, generally speaking, refer to a covalent linkage of two previously
Ligand (3,074 words) [view diff] exact match in snippet view article find links to article
atom is at the centre of a porphyrin macrocycle, being bound to four nitrogen atoms of the tetrapyrrole macrocycle. The very stable dimethylglyoximate
Thiostrepton (1,004 words) [view diff] exact match in snippet view article find links to article
dehydropiperidine core (2), thiazoline macrocycle (3), bis-dehydroalanine tail (4), and quinaldic acid macrocycle (5). Then they assembled the building
TMC-647055 (196 words) [view diff] exact match in snippet view article find links to article
HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055". Bioorganic & Medicinal Chemistry
Bottromycin (3,223 words) [view diff] exact match in snippet view article find links to article
the macrocycle. In this study, it was proposed that the methylated proline residue contributed to the restricted conformation of the macrocycle. The
Curtin–Hammett principle (3,721 words) [view diff] exact match in snippet view article find links to article
twisted 16-membered macrocycle. A key step in the syntheses is selective amide bond formation to produce the correct macrocycle. In Phil Baran’s enantioselective
Carbon nanotube chemistry (3,490 words) [view diff] exact match in snippet view article find links to article
nanotubes (SWNTs). In this strategy, the SWNTs are encapsulated by molecular macrocycle(s), which are either formed around them by macrocyclization, or pre-formed
Selenenic acid (719 words) [view diff] exact match in snippet view article find links to article
SeOH functional group within the cavity of a p-tert-butyl[calix[6]arene macrocycle]. X-ray crystallographic analysis revealed the Se-O bond length to be
Photodynamic therapy (8,879 words) [view diff] exact match in snippet view article find links to article
tetrapyrrolic molecules, with the heart of the skeleton a heterocyclic macrocycle, known as a porphine. The fundamental porphine frame consists of four
Mycolactone (788 words) [view diff] exact match in snippet view article find links to article
Barrows-Yano T, Foley TL, Wike CL, Burkart MD (April 2008). "The unusual macrocycle forming thioesterase of mycolactone". Mol. Biosyst. 4 (6): 663–671. doi:10
Teixobactin (1,429 words) [view diff] exact match in snippet view article find links to article
"Selcia Scientists Elucidate Stereochemistry of Novel Antibacterial Macrocycle Teixobactin, Published in Nature". Essex, U.K.: Selcia. Retrieved 10 January
Stevens rearrangement (694 words) [view diff] exact match in snippet view article find links to article
Kurti, Barbara Czako Academic Press (4 March, 2005) ISBN 0-12-429785-4 Macrocycle Ring Expansion by Double Stevens RearrangementKeisha K. Ellis-Holder,
Transmetalation (1,548 words) [view diff] exact match in snippet view article find links to article
carbonylative coupling of vinyl triflates with vinyl stannanes as the macrocycle-forming step". J. Am. Chem. Soc. 112 (23): 8465–8472. doi:10.1021/ja00179a035
Mechanically interlocked molecular architectures (1,086 words) [view diff] exact match in snippet view article find links to article
Jobe, Kajally; Watkinson, Michael; Goldup, Stephen M. (2011-04-26). "Macrocycle Size Matters: "Small" Functionalized Rotaxanes in Excellent Yield Using
Sandwich compound (1,667 words) [view diff] exact match in snippet view article find links to article
octahedral "carbon-wired" system shown below, which contains a planar C16B8 macrocycle. In these anti-bimetallic compounds, the metals are found to be bridged
CAPS (buffer) (137 words) [view diff] exact match in snippet view article
L.; Cable, Morgan L.; Gray, Harry B.; Ponce, Adrian (2010). "Terbium-Macrocycle Complexes as Chemical Sensors: Detection of an Aspirin Metabolite in Urine
Bioinorganic chemistry (2,381 words) [view diff] exact match in snippet view article find links to article
crystallographically by Dorothy Crowfoot Hodgkin to consist of a cobalt in a corrin macrocycle. The Watson-Crick structure for DNA demonstrated the key structural role
Ring-closing metathesis (4,707 words) [view diff] exact match in snippet view article find links to article
Siegfried Warwel and Hans Kaitker published a synthesis of symmetric macrocycles through a cross-metathesis dimerization of starting cycloolefins to afford
Pseudomonas denitrificans (286 words) [view diff] exact match in snippet view article find links to article
Cameron, B.; Crouzet, J.; Blanche, F. (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". Journal of Bacteriology
Organomolybdenum chemistry (1,929 words) [view diff] exact match in snippet view article find links to article
Hyeon Mo Cho; Jeffrey S. Moore (2007). "Preparation of a Carbazole-Based Macrocycle via Precipitation-driven Alkyne Metathesis" (PDF). Org. Synth. 84: 177
Kendomycin (333 words) [view diff] exact match in snippet view article find links to article
Synthesis of (−)-Kendomycin Featuring a Prins-Cyclization to Construct the Macrocycle". J. Am. Chem. Soc. 130 (13): 13177–81. doi:10.1021/ja805187p. PMC 2697922
Epothilone (2,043 words) [view diff] exact match in snippet view article find links to article
polyketide macrolactone with a methylthiazole group connected to the macrocycle by an olefinic bond. The polyketide backbone was synthesized by type I
4+4 Photocycloaddition (901 words) [view diff] exact match in snippet view article find links to article
this reaction first forms fused rings, subsequent cleavages can afford macrocycles. In this partial synthesis of the BC rings of Taxol, the framework buildup
Precorrin-3B synthase (261 words) [view diff] exact match in snippet view article find links to article
Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22):
Pinnatoxin (1,660 words) [view diff] exact match in snippet view article find links to article
Shu-zhen; Chen, Hai-sheng (January 1995). "Pinnatoxin A: a toxic amphoteric macrocycle from the Okinawan bivalve Pinna muricata". Journal of the American Chemical
Conotoxin (1,483 words) [view diff] exact match in snippet view article find links to article
disulfide-through-disulfide knot, in which the III-VI disulfide bond crosses the macrocycle formed by two other disulfide bonds (I-IV and II-V) and the interconnecting
Pheophorbide a oxygenase (334 words) [view diff] exact match in snippet view article find links to article
in chlorophyll breakdown in higher plants. Cleavage of pheophorbide a macrocycle by a monooxygenase". The Journal of Biological Chemistry. 273 (25): 15335–9
Robinson–Gabriel synthesis (1,112 words) [view diff] exact match in snippet view article find links to article
PMID 15469287. Zhang, J; Ciufolini, M.A. (2011). "An Approach to the Bis-oxazole Macrocycle of Diazonamides". Org. Lett. 13 (3): 390–393. doi:10.1021/ol102678j. PMID 21174393
Sue Gibson (chemist) (738 words) [view diff] exact match in snippet view article
ligand design, amino acid and peptide synthesis, medicinal chemistry, macrocycle synthesis, asymmetric induction, dendrimer construction, linker technology
Alkyne metathesis (1,230 words) [view diff] exact match in snippet view article find links to article
Hyeon Mo Cho; Jeffrey S. Moore (2007). "Preparation of a Carbazole-Based Macrocycle via Precipitation-driven Alkyne Metathesis". Org. Synth. 84: 177. doi:10
Plerixafor (1,637 words) [view diff] exact match in snippet view article find links to article
plerixafor is its zinc complex. Three of the four nitrogen atoms of the macrocycle cyclam... (1,4,8,11-tetraazacyclotetradecane) are protected with tosyl
Linaclotide (1,526 words) [view diff] exact match in snippet view article find links to article
of linaclotide to around $414 in 2018. Oh, See Arr (August 17, 2011). "Macrocycle Milestone for Ironwood Pharma". The Haystack. Retrieved 11 February 2017
Precorrin-6A synthase (deacetylating) (185 words) [view diff] exact match in snippet view article
Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22):
Methyl 2-bromoacetate (453 words) [view diff] exact match in snippet view article find links to article
selective colorimetric anion sensor based on an amide group containing macrocycle†". The Royal Society of Chemistry. Raju, B.; Murphy, E.; Levy, L.A.; Hall
Oxygen reduction reaction (1,207 words) [view diff] exact match in snippet view article find links to article
Miller, Jeffrey T.; Surendranath, Yogesh (2020-10-19). "A pyridinic Fe-N 4 macrocycle models the active sites in Fe/N-doped carbon electrocatalysts". Nature
Molecular switch (1,692 words) [view diff] exact match in snippet view article find links to article
architectures where the bistable states differ in the position of the macrocycle. In 1991 Stoddart devices a molecular shuttle based on a rotaxane on which
Precorrin-2 C20-methyltransferase (259 words) [view diff] exact match in snippet view article find links to article
Cameron B, Crouzet J, Blanche F (1993). "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22):
Humulene (1,704 words) [view diff] exact match in snippet view article find links to article
in the laboratory, involving differing closures of the C-C bond in the macrocycle. The McMurry synthesis uses a titanium-catalyzed carbonyl coupling reaction;
Paal–Knorr synthesis (1,625 words) [view diff] exact match in snippet view article find links to article
prior to isolation. In 1982, H. Hart et al. reported a synthesis of a macrocycle containing fused furan rings using a Paal–Knorr furan synthesis. Refluxing
Ferrochelatase (1,985 words) [view diff] exact match in snippet view article find links to article
investigation. Many researchers have hypothesized distortion of the porphyrin macrocycle as key to catalysis. Researchers studying Bacillus subtilis ferrochelatase
Atrop-abyssomicin C (852 words) [view diff] exact match in snippet view article find links to article
that was proposed to be the reactive center. Despite being a strained macrocycle, there exist an atropisomer, abyssomicin C. The atropisomerism arise due
Wulff–Dötz reaction (1,501 words) [view diff] exact match in snippet view article find links to article
"Application of the Dötz Reaction to Construction of a Major Portion of the Ansa Macrocycle (−)-Kendomycin". Organic Letters. 7 (2): 235–238. doi:10.1021/ol047779s
Transporter Classification Database (5,137 words) [view diff] exact match in snippet view article find links to article
51 The Protein Nanopore (ProNP) Family 1.D.52 The Aromatic Oligoamide Macrocycle Nanopore (OmnNP) Family 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT)
Metalloprotein (5,365 words) [view diff] exact match in snippet view article find links to article
to iron (Fe) in hemoglobin. Additionally, chlorophyll has an extended isoprenoid tail and an additional aliphatic cyclic structure off the macrocycle.
Liebeskind–Srogl coupling (1,398 words) [view diff] exact match in snippet view article find links to article
employing this reaction to construct the north eastern fragment of the macrocycle and the terpene chain. Directed Difunctionalization The Yu lab has demonstrated
Zotiraciclib (588 words) [view diff] exact match in snippet view article find links to article
Singapore by S*BIO Pte Ltd and falls under the category of small molecule macrocycles. It crosses the blood brain barrier and acts by depleting Myc through
Persistent radical effect (705 words) [view diff] exact match in snippet view article find links to article
selectivity in a free-radical reaction involving persistent .cntdot.CoII[macrocycle] and alkyl free radicals Brian E. Daikh and Richard G. Finke Journal of
Cyclol (6,785 words) [view diff] exact match in snippet view article find links to article
configuration effect and the transannular intrinsic rates in bislactam macrocycles". Journal of the Chemical Society, Perkin Transactions 2. 2002 (12):
Naturally occurring phenols (7,614 words) [view diff] exact match in snippet view article find links to article
An example of such molecules is catechin. Cavicularin is an unusual macrocycle because it was the first compound isolated from nature displaying optical
Cytochalasin B (3,947 words) [view diff] exact match in snippet view article find links to article
an intermolecular Diels-Alder reaction and in a second step append the macrocycle in a stepwise fashion. Cytochalasin B contains several highly polar keto-
Erythronolide synthase (2,952 words) [view diff] exact match in snippet view article find links to article
Chen JC, Foster PG, et al. (December 2001). "Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility
Kinetic isotope effect (14,307 words) [view diff] exact match in snippet view article find links to article
smaller effective size, allows easier passage of the stoppers through the macrocycle, resulting in faster rates of deslipping for the deuterated rotaxanes
Aza-Cope rearrangement (5,689 words) [view diff] exact match in snippet view article find links to article
iminium ions stay in close enough proximity to undergo Mannich cyclization. Macrocycle synthesis has not been reported using this reaction, due to the lack of
Vitamin B12 total synthesis (7,408 words) [view diff] exact match in snippet view article find links to article
vitamin B12.: 1563  At Harvard, it was shown that the closure to the corrin macrocycle could also be realized by the method of thioiminoester/enamine condensation