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searching for MTORC2 24 found (48 total)

alternate case: mTORC2

Michael N. Hall (1,742 words) [view diff] exact match in snippet view article find links to article

mTORC2) is not inhibited by rapamycin and regulates a different signaling pathway from mTORC1. Hall also identified many roles of mTORC1 and mTORC2,

MAPK4 (602 words) [view diff] exact match in snippet view article find links to article

phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression

LANCL2 (1,154 words) [view diff] exact match in snippet view article find links to article

phosphorylation of Akt through its interaction with the Akt kinase mTORC2. Active mTORC2 causes translocation of GLUT4 to the plasma membrane and stimulates

Phosphatidylinositol 3,4-bisphosphate (2,104 words) [view diff] exact match in snippet view article find links to article

Phosphoinositide-dependent kinase-1 (PDK1) and mechanistic target of Rapamycin Complex 2 (mTORC2), respectively. Test tube experiments have shown that the essential recruitment

Akt/PKB signaling pathway (4,116 words) [view diff] exact match in snippet view article find links to article

integrin-linked kinase (ILK), mechanistic target of rapamycin complex complex 2 (mTORC2) and DNA-dependent protein kinase (DNA-PK). The regulation of Ser473 phosphorylation

PHLPP (1,431 words) [view diff] exact match in snippet view article find links to article

hydrophobic motif, is phosphorylated in an mTORC2-dependent manner, leading some investigators to hypothesize that mTORC2 is the long-sought PDK2 molecule. Threonine308

Lysosome (4,709 words) [view diff] exact match in snippet view article find links to article

The failure to degrade internalized immune complexes stems from chronic mTORC2 activity, which impairs lysosome acidification. As a result, immune complexes

Lymphangioleiomyomatosis (11,094 words) [view diff] exact match in snippet view article find links to article

rapamycin-insensitive mTORC2. MTORC1 consists of five proteins including Raptor that positively regulate mTOR activity. MTORC2 consists of six proteins

Ralf Baumeister (74 words) [view diff] exact match in snippet view article find links to article

Research Prize by the Hans- and Ilse Breuer Foundation Scientific career Fields Diseases, Drug Discovery, mTORC2, Autophagy Website https://celegans.de/

SYAP1 (408 words) [view diff] exact match in snippet view article find links to article

Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA (January 2013). "BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate

Paul Khavari (1,802 words) [view diff] exact match in snippet view article find links to article

noncoding snoRNAs as direct Ras-binders that modulate its function and mTORC2 as a new direct Ras downstream effector critical for the pro-proliferation

BSD domain (299 words) [view diff] exact match in snippet view article find links to article

Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA (January 2013). "BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate

P70-S6 Kinase 1 (2,127 words) [view diff] exact match in snippet view article find links to article

mTOR-containing complex characterized by the inclusion of Raptor rather than Rictor (mTORC2). mTOR can be activated via an AND-gate-like mechanism at the lysosome,

S. Murty Srinivasula (1,517 words) [view diff] exact match in snippet view article find links to article

Alessi D, Offermanns S, Simon MI, Wu D. (2012). PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα (12)

Caspase 11 (1,388 words) [view diff] exact match in snippet view article find links to article

Claiborne TM, Rajfur Z, Jacobson K, Moorman NJ, Vilen BJ (July 2018). "mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus

PPP6R3 (385 words) [view diff] exact match in snippet view article find links to article

(July 2021). "Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells". Journal of Biochemistry. 170 (1): 131–138. doi:10

Tobias Huber (856 words) [view diff] exact match in snippet view article find links to article

Hall, M. N., Walz, G., Korbmacher, C., Artunc, F., and Huber, T. B. 2016. mTORC2 critically regulates renal potassium handling. J Clin Invest doi:10.1172/jci80304

Caspase 1 (2,392 words) [view diff] exact match in snippet view article find links to article

Vincent HA, Kang S, Li P, Claiborne TM, Rajfur Z, et al. (July 2018). "mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus

Oncogene (3,182 words) [view diff] exact match in snippet view article find links to article

Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2". International Journal of Molecular Sciences. 23 (15): 8798. doi:10.3390/ijms23158798

Gedatolisib (855 words) [view diff] exact match in snippet view article find links to article

distinct protein assemblies: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTOR signaling serves as a central regulator of cell metabolism, growth

Suzanne Zukin (1,380 words) [view diff] exact match in snippet view article find links to article

autism spectrum disorders. The lab has found that the downstream targets of mTORC2, Rho GTPase Rac1 and LIMK exhibit increased expression in a mouse model

Opioid use disorder (12,649 words) [view diff] exact match in snippet view article find links to article

protein kinase B (AKT), and mechanistic target of rapamycin complex 2 (mTORC2). As a result of downregulated signaling through these proteins, opiates

C2orf72 (979 words) [view diff] exact match in snippet view article find links to article

(February 2019). "The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2". Molecular Cell. 73 (4): 830–844.e12. doi:10.1016/j.molcel.2018.12.001

Soluble NSF attachment protein (3,344 words) [view diff] exact match in snippet view article find links to article

M (May 2017). "Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation". eLife