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searching for Helix bundle 106 found (135 total)

Adnaviria (1,666 words) [view diff] exact match in snippet view article find links to article

major capsid protein (MCP) that contains the SIRV2 fold, a type of alpha-helix bundle containing four helices. The virion consists of the genome encased in

DEP domain (378 words) [view diff] exact match in snippet view article find links to article

resonance spectroscopy has revealed that the DEP domain comprises a three-helix bundle, a beta-hairpin 'arm' composed of two beta-strands and two short beta-strands

L27 domain (594 words) [view diff] exact match in snippet view article find links to article

to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two

BamHI (1,223 words) [view diff] exact match in snippet view article find links to article

contacts are formed by atoms residing on the amino-terminus of a parallel 4 helix bundle. This bundle marks the BamHI dimer interface, and it is thought that

Focal adhesion targeting region (363 words) [view diff] exact match in snippet view article find links to article

attachment points. The crystal structure of FAT shows it to form a four-helix bundle that binds specifically to Leucine-Aspartate (LD)-repeat motif peptides

Nematode Her-1 (174 words) [view diff] exact match in snippet view article find links to article

with two subdomains: amino acids 19-80 comprise a left-handed three-helix bundle with an overhand connection between the second and third helices, whilst

Plant lipid transfer proteins (1,062 words) [view diff] exact match in snippet view article find links to article

These proteins share the same superhelical, disulfide-stabilised four-helix bundle containing an internal cavity. There is no sequence similarity between

Protein A (1,860 words) [view diff] exact match in snippet view article find links to article

composed of five homologous Ig-binding domains that fold into a three-helix bundle. Each domain is able to bind proteins from many mammalian species, most

Cbl TKB domain (181 words) [view diff] exact match in snippet view article find links to article

composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together

GA module (320 words) [view diff] exact match in snippet view article find links to article

human serum albumin. The GA module is composed of a left-handed three-helix bundle and is found in a range of bacterial cell surface proteins. GA modules

Zuotin (338 words) [view diff] no match in snippet view article find links to article

to a subunit-spanning medium domain (MD), the "neck" of RAC. The four-helix-bundle RAC head domain is located at the C-terminus and binds the small (40S)

Epsilon antitoxin (115 words) [view diff] exact match in snippet view article find links to article

cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it. Meinhart

SNARE protein (6,592 words) [view diff] exact match in snippet view article find links to article

classified as Qa-, Qb-, or Qc-SNAREs depending on their location in the four-helix bundle. Variants are known from yeasts, mammals, plants, Drosophila, and Caenorhabditis

Affibody molecule (2,394 words) [view diff] exact match in snippet view article find links to article

composed of alpha helices and lack disulfide bridges. The parent three-helix bundle structure is currently the fastest folding protein structure known. Specific

Gp41 (1,709 words) [view diff] exact match in snippet view article find links to article

formed following the conformational change in gp41 that creates the six-helix bundle. These pockets could potentially serve as targets for small molecule

STX6 (1,378 words) [view diff] exact match in snippet view article find links to article

SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that

Ligamenvirales (560 words) [view diff] exact match in snippet view article find links to article

proteins of both lipothrixviruses and rudiviruses have an unusual four-helix bundle topology. The genome is non-segmented linear double stranded DNA. Viruses

Inositol phosphate (516 words) [view diff] exact match in snippet view article find links to article

cells. Inositol hexaphosphate also facilitates the formation of the six-helix bundle and assembly of the immature HIV-1 Gag lattice. IP6 makes ionic contacts

Interleukin 4 (2,297 words) [view diff] exact match in snippet view article find links to article

disulphide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist. The helices are anti-parallel, with 2 overhand

William DeGrado (1,741 words) [view diff] exact match in snippet view article find links to article

1999). "Solution structure and dynamics of a de novo designed three-helix bundle protein". Proceedings of the National Academy of Sciences. 96 (10): 5486–5491

Proteasome accessory factor E (760 words) [view diff] exact match in snippet view article find links to article

12-fold symmetry. Each monomer is composed of 174 residues and forms four-helix bundle structure. The crystal structure revealed three unpredicted features

Munc-18 (806 words) [view diff] exact match in snippet view article find links to article

March 2010). "Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle". Biochemistry. 49 (8): 1568–76. doi:10.1021/bi9021878. PMC 2834481.

Hemoprotein (2,454 words) [view diff] exact match in snippet view article find links to article

Robertson DE, DeGrado WF (1994-02-01). "Design of a heme-binding four-helix bundle". Journal of the American Chemical Society. 116 (3): 856–865. doi:10

Antibody mimetic (732 words) [view diff] exact match in snippet view article find links to article

binding proteins: affibody binding proteins developed from a small three-helix bundle scaffold". FEBS J. 275 (11): 2668–76. doi:10.1111/j.1742-4658.2008.06438

Methionine synthase (3,437 words) [view diff] exact match in snippet view article find links to article

is in turn capped by the other subdomain, the four-helix bundle cap subdomain. The four-helix bundle serves to protect the cobalamin cofactor from unwanted

Dysferlin (3,501 words) [view diff] exact match in snippet view article find links to article

conserved among all members of ferlin protein family. FerA domain is a four helix bundle and it can interact with membrane, usually in a calcium-dependent manner

Pho4 (859 words) [view diff] exact match in snippet view article find links to article

homodimer and the two monomers fold into a parallel, left-handed four-helix bundle. PHO4 protein lacks an inner hydrogen network. Pho4 is a transcription

Theories of general anaesthetic action (6,813 words) [view diff] exact match in snippet view article find links to article

Dutton PL (1998). "A designed cavity in the hydrophobic core of a four-α-helix bundle improves volatile anesthetic binding affinity". Biochemistry. 37 (5):

CASS4 (3,332 words) [view diff] exact match in snippet view article find links to article

carboxy-terminus, they have a four-helix bundle rich in serine residues, and a second highly conserved four-helix bundle that has been recognized as functionally

Interleukin (4,194 words) [view diff] exact match in snippet view article find links to article

structures, IL5 is a homodimer. The fold contains an anti-parallel 4-alpha-helix bundle with a left handed twist, connected by a 2-stranded anti-parallel beta-sheet

NT5C3 (1,670 words) [view diff] exact match in snippet view article find links to article

superfamily in regards to the shared α/β-Rossmann-like domain and a smaller 4-helix bundle domain. Three motifs in the α/β-Rossmann-like domain form the catalytic

EcoRI (891 words) [view diff] exact match in snippet view article find links to article

complex, two α-helices from each subunit come together to form a four-helix bundle. On the interacting helices are residues Glu144 and Arg145, which interact

Reuptake (1,897 words) [view diff] exact match in snippet view article find links to article

a mechanism for conformational change was proposed in which a four-helix bundle composed of TMs 1, 2, 6 and 7 changes its orientation within the rest

Granulocyte colony-stimulating factor (3,829 words) [view diff] no match in snippet view article find links to article

colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein". Biochemistry. 33 (28): 8453–8463. doi:10.1021/bi00194a009.

Otoferlin (1,319 words) [view diff] case mismatch in snippet view article find links to article

Rice AM, Sutton RB (July 2018). "FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins". Scientific

Cry6Aa (1,609 words) [view diff] exact match in snippet view article find links to article

with functional homology across proteins, domain I contains an alpha helix bundle, domain II is composed of three antiparallel beta sheets in a Greek key

Lac repressor (1,690 words) [view diff] exact match in snippet view article find links to article

C-terminal tetramerization region (which joins four monomers in an alpha-helix bundle) DNA binding occurs via an N-terminal helix-turn-helix structural motif

Formate dehydrogenase (959 words) [view diff] exact match in snippet view article find links to article

four transmembrane helices and two heme b groups which produce a four-helix bundle which aids in heme binding. The heme b cofactors bound to the gamma subunit

Apolipoprotein (1,891 words) [view diff] exact match in snippet view article find links to article

of apoE indicates that the protein forms an unusually elongated four-helix bundle that may be stabilised by a tightly packed hydrophobic core that includes

Cyclin D (4,605 words) [view diff] exact match in snippet view article find links to article

compact domains with each having five alpha helices. The first five-helix bundle is a conserved cyclin box, a region of about 100 amino acid residues

Pantothenate kinase (2,484 words) [view diff] exact match in snippet view article find links to article

residues. At the N-terminal end, each helix widens and forms a four-helix bundle with two shorter helices. This bundle consists of a hydrophobic core

Pyruvate dehydrogenase lipoamide kinase isozyme 1 (1,616 words) [view diff] exact match in snippet view article find links to article

lipoyl-binding pocket of PDK1. Dichloroacetic acid was found near the helix bundle in the N-terminal domain of PDK1. Bound DCA promotes local conformational

Apolipophorin III (229 words) [view diff] no match in snippet view article find links to article

"Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1188–93

Dermcidin (1,224 words) [view diff] no match in snippet view article find links to article

structure of dermcidin has been solved in solution to reveal a hexameric helix-bundle, mediated by Zn ion binding. This is observed to form a tilted channel

CLCF1 (861 words) [view diff] exact match in snippet view article find links to article

IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins

Histidine kinase (2,112 words) [view diff] exact match in snippet view article find links to article

made of three α helices. The dimeric unit is held together by a four-helix bundle, formed when the C-terminal segments of the α1 helices on each subunit

Supersecondary structure (804 words) [view diff] exact match in snippet view article find links to article

residues. The function of a helix hairpin is unknown; however, a four helix bundle is composed of two helix hairpins, which have important ligand binding

Apolipoprotein E (6,576 words) [view diff] exact match in snippet view article find links to article

The N-terminal region (residues 1–167) forms an anti-parallel four-helix bundle such that the non-polar sides face inside the protein. Meanwhile, the

Atlastin (1,493 words) [view diff] exact match in snippet view article find links to article

conserved domain structure consisting of a globular G domain, a three-helix bundle, two transmembrane domains, and an amphipathic helix. The ATL fusion

Basic helix–loop–helix (1,402 words) [view diff] exact match in snippet view article find links to article

crystallize bHLH proteins bound to E-boxes, demonstrating that the parallel 4-helix bundle motif loop orients the basic sequences to interact with specific nucleotides

Interleukin 30 (1,800 words) [view diff] exact match in snippet view article find links to article

kilodaltons (thus the name IL27-p28). It is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6. The human

HNRNPC (1,580 words) [view diff] exact match in snippet view article find links to article

Braswell EH, LeStourgeon WM, Krezel AM (2001). "An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for

Vicriviroc (2,046 words) [view diff] exact match in snippet view article find links to article

brings together two trimeric coiled coils, HR1 and HR2, to form a six-helix bundle. The bundle allows the viral and cellular membranes to approximate and

Β-Galactosidase (3,025 words) [view diff] exact match in snippet view article find links to article

in a subunit interface. Its residues 22–31 help to stabilize a four-helix bundle which forms the major part of that interface, and residue 13 and 15 also

Myoferlin (711 words) [view diff] case mismatch in snippet view article find links to article

Rice AM, Sutton RB (July 2018). "FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins". Scientific

Talin (protein) (1,874 words) [view diff] exact match in snippet view article

vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle". The EMBO Journal. 23 (15): 2942–51. doi:10.1038/sj.emboj.7600285. PMC 514914

UBA1 (2,374 words) [view diff] exact match in snippet view article find links to article

cysteine inserted into each of the adenylation domains; third, a four-helix bundle that represents a second insertion in the inactive adenylation domain

Secretion (2,981 words) [view diff] exact match in snippet view article find links to article

As shown in the above figure, TraC, in particular consists of a three helix bundle and a loose globular appendage. T4SS has two effector proteins: firstly

Complexin (1,126 words) [view diff] exact match in snippet view article find links to article

N-terminal alpha-helix domain incorporates itself into the SNARE complex helix bundle and prevents zippering of the assembly. In contrast to this, another

Phytic acid (2,558 words) [view diff] exact match in snippet view article find links to article

proteins. Inositol hexaphosphate facilitates the formation of the six-helix bundle and assembly of the immature HIV-1 Gag lattice. IP6 makes ionic contacts

NT5M (818 words) [view diff] exact match in snippet view article find links to article

helix loops in the fold, whereas the small domain forms a truncated four-helix bundle which is inserted between a beta strand and alpha-helix in the large

Siah interacting protein N-terminal domain (405 words) [view diff] exact match in snippet view article find links to article

tight 3-residue turn. Hairpins from two monomers associate as a four-helix bundle. Bhattacharya S, Lee YT, Michowski W, Jastrzebska B, Filipek A, Kuznicki

SRA1 (1,401 words) [view diff] exact match in snippet view article find links to article

proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured

PYCARD (1,338 words) [view diff] exact match in snippet view article find links to article

caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling

SLBP (1,505 words) [view diff] exact match in snippet view article find links to article

formation with the histone mRNA stem-loop is achieved by a novel three-helix bundle fold. SLBP proteins also recognize the tetraloop structure of the histone

TERF2IP (1,161 words) [view diff] exact match in snippet view article find links to article

2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains"

Coronavirus spike protein (7,519 words) [view diff] exact match in snippet view article find links to article

dramatic conformational changes during the fusion process to form a six-helix bundle, a characteristic feature of the class I fusion proteins. The S2 region

Coiled coil (3,933 words) [view diff] exact match in snippet view article find links to article

onto which HR2 region coils, forming the trimer-of-hairpins (or six-helix bundle) structure, thereby facilitating membrane fusion through bringing the

MED26 (1,325 words) [view diff] exact match in snippet view article find links to article

fold known as a TFIIS N-terminal domain (or TND). It is a compact five-helix bundle. The hydrophobic core residues of helices 2, 3, and 4 are well conserved

SDHAF2 (1,258 words) [view diff] exact match in snippet view article find links to article

of flavin adenine dinucleotide (FAD). The structure represents a five-helix bundle with a region of well-defined conserved surface residues. This conserved

NT5C (1,438 words) [view diff] exact match in snippet view article find links to article

residues 1-17 and 77-201 of the amino acid sequence. The cap domain is a 4-helix bundle spanning residues 18-76. The cleft formed by the core and cap domains

BinCARD (910 words) [view diff] exact match in snippet view article find links to article

protein, is a member of the death-domain superfamily, which shares a six—helix bundle. In humans, the protein has two alternatively spliced isoforms: BinCARD-1

APOL2 (1,345 words) [view diff] exact match in snippet view article find links to article

of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif". Communications Biology. 4 (1): 916. doi:10.1038/s42003-021-02387-5

N-ethylmaleimide sensitive fusion protein (1,747 words) [view diff] exact match in snippet view article find links to article

the SNAREs coiling around each other and forming a very stable four-helix bundle. As SNAREs intertwine, they pull the vesicle towards the target membrane

SYNCRIP (1,950 words) [view diff] exact match in snippet view article find links to article

heterogeneous nuclear RNA (hnRNA). SYNCRIP is made up of an N-terminal helix bundle known as the “acidic domain” (AcD), followed by three sequential RNA

Catechol oxidase (2,314 words) [view diff] exact match in snippet view article find links to article

approximately 55 by 45 by 45 Å in size and ellipsoid in shape. A four α-helix bundle comprises the enzyme core, which girds the active site containing the

Archaeal virus (6,434 words) [view diff] exact match in snippet view article find links to article

fold, a type of alpha-helix bundle, and the MCPs of bicaudaviruses possess the ATV-like fold, another type of alpha-helix bundle. The architectural classes

Ferlins (3,105 words) [view diff] exact match in snippet view article find links to article

evidence that FerA contains four helices, which fold to form a four-helix bundle. Ferlins play roles in vesicle fusion and membrane trafficking. Different

FIS1 (1,714 words) [view diff] exact match in snippet view article find links to article

of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle". Journal of Molecular Biology. 334 (3): 445–58. doi:10.1016/j.jmb.2003

Deubiquitinating enzyme (4,317 words) [view diff] exact match in snippet view article find links to article

proline, glycine, proline and isoleucine, which packs against the three-helix bundle and is highly ordered. The full extent of the role of DUBs in diseases

Cation diffusion facilitator (1,461 words) [view diff] exact match in snippet view article find links to article

conformational change that involves pivoting of a transmembrane, four-helix bundle (M1, M2, M4, and M5) relative to the M3-M6 helix pair. Although the accessibility

Cyanobacterial clock proteins (1,168 words) [view diff] exact match in snippet view article find links to article

RecG and RuvABC. The overall fold of the KaiA monomer is that of a four-helix bundle, which forms a dimer in the known structure. KaiA functions as a homodimer

Interleukin 15 (4,458 words) [view diff] exact match in snippet view article find links to article

granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-15 belongs to the four α-helix bundle family of cytokines. IL-15 is constitutively expressed by a large number

Robert A. Lamb (1,369 words) [view diff] exact match in snippet view article find links to article

disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proceedings of the National Academy of Sciences (2011) Fusion

BCAR1 (2,861 words) [view diff] exact match in snippet view article find links to article

Following the substrate domain is the serine-rich domain, which forms a four-helix bundle. This acts as a protein-interaction motif, similar to those found in

Glutamate carboxypeptidase II (4,317 words) [view diff] exact match in snippet view article find links to article

the protease domain. The C-terminal domain is an Up-Down-Up-Down four-helix bundle. The apical, protease and C-terminal domains create a pocket that facilitates

Nucleosome (6,666 words) [view diff] exact match in snippet view article find links to article

orientation, and, in the case of H3 and H4, two such dimers form a 4-helix bundle stabilised by extensive H3-H3' interaction. The H2A/H2B dimer binds onto

Sean M. Decatur (1,916 words) [view diff] case mismatch in snippet view article find links to article

“Amide I Frequency as a Probe of Tertiary Structure: FTIR Studies of Helix Bundle Peptides,” Peptides: The Wave of the Future, edited by M. Lebl and R

Muconate lactonizing enzyme (2,057 words) [view diff] exact match in snippet view article find links to article

has 4 regions of secondary structures:- 1) A Beta- meander 2) An Alpha-helix bundle 3) An eight -stranded Alpha/Beta Barrel 4)a C-terminal mixed domain Yes

Cytochrome c family (2,202 words) [view diff] exact match in snippet view article find links to article

The structural fold of class II c-type cytochromes contains a four α-helix bundle with the covalently attached heme group at its core. Representatives

Autophagy protein 5 (2,808 words) [view diff] no match in snippet view article find links to article

HR is composed of three long and one short alpha helices, forming a helix-bundle structure. ATG5 is regulated by the p73 from the p53 family of transcription

Cyanase (1,543 words) [view diff] exact match in snippet view article find links to article

N-terminal domain shows structural similarity to the DNA-binding alpha-helix bundle motif. The C-terminal domain has an 'open fold' with no structural homology

Serum amyloid A1 (4,261 words) [view diff] exact match in snippet view article find links to article

Native SAA1 is a hexamer with each subunit assuming an antiparallel 4-helix bundle structure. The structure is cone-shaped with its apex forming a binding

Perilipin-1 (3,315 words) [view diff] exact match in snippet view article find links to article

amphipathic helixes with an active role in linking membranes and a 4-helix bundle before the C-terminal carbon. In Perilipin A, lipophile nature is conferred

SWEET transporters (1,780 words) [view diff] exact match in snippet view article find links to article

members function as carriers. Bacterial SemiSWEETs, consist of a triple-helix bundle in a 1-3-2 conformation, with TM3 sandwiched between TM1 and TM2. The

Avian metaavulavirus 2 (1,989 words) [view diff] exact match in snippet view article find links to article

is believed that two heptad repeat regions (HR1) and (HR2) form a six-helix bundle structure that helps to induce fusion of the viral membrane with the

CCR5 receptor antagonist (5,518 words) [view diff] exact match in snippet view article find links to article

transmembrane segment receptors. The structure of the receptor comprises seven-helix bundle in the transmembrane region, these regions are labeled I–VII in figures

Apomyoglobin (1,470 words) [view diff] case mismatch in snippet view article find links to article

(2001-12-01). "Diffusion-Collision Model Study of Misfolding in aFour-Helix Bundle Protein". Biophysical Journal. 81 (6): 3105–3115. doi:10.1016/S0006-3495(01)75948-6

Antifreeze protein (6,351 words) [view diff] exact match in snippet view article find links to article

glutamine. This protein is approximately 12KDa in size and consists of a 4-helix bundle. Its only posttranslational modification is a pyroglutamate residue,

BRCA2 (7,893 words) [view diff] exact match in snippet view article find links to article

of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is

Cohesin (6,843 words) [view diff] exact match in snippet view article find links to article

N-terminal domain of RAD21 contains two α-helices which forms a three helix bundle with the coiled coil of SMC3. The central region of RAD21 is thought

Management of HIV/AIDS (15,784 words) [view diff] exact match in snippet view article find links to article

N-terminal heptad repeat of gp41 of HIV to form an inactive hetero six-helix bundle, therefore preventing infection of host cells. Nucleoside reverse-transcriptase

Variant surface glycoprotein (3,690 words) [view diff] exact match in snippet view article find links to article

which form the dimerization interface, and which couple into a four helix bundle), while still allowing for variable primary sequence. This variable primary

S100A1 (4,914 words) [view diff] exact match in snippet view article find links to article

or tighter), and is formed through hydrophobic packing of an X-type 4-helix bundle created between helices 1, 1', 4, and 4'. Protein nuclear magnetic resonance

Embryonal fyn-associated substrate (4,850 words) [view diff] exact match in snippet view article find links to article

and Crk-L, a Crk1 paralogue. A serine-rich domain encompassing a 4 α-helix bundle (amino acids 351-488 for human EFS). Although primary amino acid sequence

Murine respirovirus (32,094 words) [view diff] exact match in snippet view article find links to article

domains of the F-protein promotes the establishment of a stable six-helix bundle structure (6HB). The formation of the 6HB structure leads to the establishment