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searching for Gamma secretase 35 found (79 total)

TMED10 (900 words) [view diff] no match in snippet view article find links to article

member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations

Serum B-cell maturation antigen (2,633 words) [view diff] exact match in snippet view article find links to article

and antibody production. The membrane bound BCMA can be cleaved by gamma secretase, resulting in sBCMA, and released into the blood. Serum BCMA is found

SPPL2B (733 words) [view diff] no match in snippet view article find links to article

PMID 16829952. S2CID 129089. Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease

BMS-906024 (257 words) [view diff] case mismatch in snippet view article find links to article

Lee FY, Shah JJ, Bertino JR, Rosenfeld J, et al. (December 2017). "Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma"

Rudolph E. Tanzi (4,371 words) [view diff] exact match in snippet view article find links to article

Steven Wagner began screening for a class of drugs that they termed "gamma secretase modulators (GSM)". GSM's reverse the Abeta42:Abeta40 ratio and thereby

APLP1 (1,179 words) [view diff] no match in snippet view article find links to article

(2003). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription". J. Biol. Chem. 277 (46): 44195–201. doi:10

LRP1B (650 words) [view diff] no match in snippet view article find links to article

S2CID 30699151. Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein

SCN2B (548 words) [view diff] no match in snippet view article find links to article

PMID 15489334. Kim DY, Ingano LA, Carey BW, et al. (2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit

ORMDL1 (209 words) [view diff] no match in snippet view article find links to article

family of membrane proteins associated with presenilin expression and gamma-secretase function". FASEB J. 22 (3): 819–27. doi:10.1096/fj.07-9072com. PMID 17928364

Signal peptide peptidase (914 words) [view diff] no match in snippet view article find links to article

PMID 16829952. S2CID 129089. Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease

NUMBL (607 words) [view diff] no match in snippet view article find links to article

PMID 9169836. Roncarati R, Sestan N, Scheinfeld MH, et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds

Early-onset Alzheimer's disease (3,741 words) [view diff] no match in snippet view article find links to article

domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities". Neuromolecular Medicine. 1 (1): 43–54. doi:10.1385/NMM:1:1:43

SPPL2A (715 words) [view diff] no match in snippet view article find links to article

PMID 16829952. S2CID 129089. Fluhrer R, Grammer G, Israel L, et al. (2006). "A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease

Diazirine (2,594 words) [view diff] no match in snippet view article find links to article

site. The discovery that caprolactam-type gamma-secretase inhibitors target the SPP subunit of the gamma-secretase, which has been implicated in Alzheimer's

UBQLN2 (1,042 words) [view diff] no match in snippet view article find links to article

(2006). "Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin". Biochem. J. 391 (Pt 3): 513–25. doi:10

PTPRK (4,376 words) [view diff] exact match in snippet view article find links to article

PΔE. The membrane tethered PΔE fragment is further cleaved by the gamma secretase complex to yield a membrane-released fragment, PIC, that can translocate

Bart De Strooper (622 words) [view diff] no match in snippet view article find links to article

Wolfe, M. S.; Ray, W. J.; Goate, A. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature

APPBP2 (574 words) [view diff] no match in snippet view article find links to article

091582298. PMC 33278. PMID 11331760. Gao Y, Pimplikar SW (2002). "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling

JAG2 (1,018 words) [view diff] no match in snippet view article find links to article

ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200

Delta-like 1 (1,065 words) [view diff] no match in snippet view article find links to article

Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37

HM13 (1,137 words) [view diff] no match in snippet view article find links to article

peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor". J Biol Chem. 279 (15): 15153–60. doi:10.1074/jbc.M309305200

MIPEP (1,115 words) [view diff] no match in snippet view article find links to article

PMID 7490080. Lee SF, Srinivasan B, Sephton CF, et al. (Aug 2011). "Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate

Betacellulin (1,786 words) [view diff] no match in snippet view article find links to article

PMID 16381901. Stoeck A, Shang L, Dempsey PJ (July 2010). "Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated

TMED2 (555 words) [view diff] no match in snippet view article find links to article

(April 2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur

Ferritin light chain (1,879 words) [view diff] no match in snippet view article find links to article

May 2013). "Ferritin light chain interacts with PEN-2 and affects gamma- secretase activity". Neuroscience Letters. 548: 90–94. doi:10.1016/j.neulet.2013

Cholesterol signaling (1,790 words) [view diff] exact match in snippet view article find links to article

cholesterol controls the clustering of amyloid precursor protein with gamma secretase in GM1 lipid domains. High cholesterol induces APP hydrolysis and the

Neuregulin 1 (4,863 words) [view diff] no match in snippet view article find links to article

Höglinger GU, D'Hooge R, De Strooper B (2008). "Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed

Sodium channel (5,625 words) [view diff] no match in snippet view article find links to article

Ingano LA, Carey BW, Pettingell WH, Kovacs DM (June 2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit

Alison Goate (2,373 words) [view diff] no match in snippet view article find links to article

18, 2019. De Strooper, B.; et al. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature

Epithelioid sarcoma (5,913 words) [view diff] no match in snippet view article find links to article

PMID 25098767. Clinical trial number NCT01154452 for "Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With

Down syndrome (14,784 words) [view diff] exact match in snippet view article find links to article

therapy. Other methods being studied include the use of antioxidants, gamma secretase inhibition, adrenergic agonists, and memantine. Research is often carried

MTOR (12,682 words) [view diff] no match in snippet view article find links to article

activity compared to controls, and the hyperactivity is blocked using a gamma-secretase inhibitor. These in vitro studies suggest that increasing Aβ concentrations

List of intestinal epithelial differentiation genes (3,330 words) [view diff] no match in snippet view article find links to article

Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas

Biochemistry of Alzheimer's disease (9,040 words) [view diff] no match in snippet view article find links to article

risk gene products including the amyloid precursor protein (APP) and gamma-secretase, as well as the APOE receptors and GWAS risk loci take part in similar

Voltage-gated sodium channel (3,706 words) [view diff] no match in snippet view article find links to article

Ingano LA, Carey BW, Pettingell WH, Kovacs DM (June 2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit