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searching for Double minute 14 found (23 total)

Ubiquitin ligase (4,436 words) [view diff] exact match in snippet view article find links to article

Haitel A, Shariat SF, Klatte T (February 2015). "The T309G murine double minute 2 gene polymorphism is an independent prognostic factor for patients

Protein kinase B (3,839 words) [view diff] exact match in snippet view article find links to article

Bcl-2 family proteins, master lysosomal regulator TFEB and murine double minute 2 (MDM2). Akt kinases can promote growth factor-mediated cell survival

SUMO protein (4,930 words) [view diff] case mismatch in snippet view article find links to article

there is a regulatory ubiquitin ligase protein in humans called Mouse Double Minute 2 protein, or MDM2, which acts to remove p53 from the cell. MDM2 regulates

Akt/PKB signaling pathway (4,072 words) [view diff] exact match in snippet view article find links to article

genes, such as Bcl-2. Akt has also been shown to phosphorylate murine double minute 2 (Mdm2), a key regulator of DNA damage responses, at Ser166 and Ser186

NPM1 (4,859 words) [view diff] exact match in snippet view article find links to article

and Rex peptide p53 tumor suppressor ARF tumor suppressor MDM2 (mouse double minute 2, ubiquitin ligase) Ribosome protein S9 Phosphatidylinositol 3,4,5-triphosphate

H. Michael Shepard (737 words) [view diff] exact match in snippet view article find links to article

patent 6,946,259 — Compositions and methods for treating cells having double minute DNA U.S. patent 6,683,061 — Enzyme catalyzed therapeutic activation

MDM4 (1,214 words) [view diff] exact match in snippet view article find links to article

PMID 9226370. S2CID 11794685. "Entrez Gene: MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)". Strachan GD, Jordan-Sciutto KL, Rallapalli

UQCRFS1 (1,284 words) [view diff] exact match in snippet view article find links to article

Sait SN, Qadir MU, Conroy JM, Matsui S, Nowak NJ, Baer MR (May 2002). "Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome:

TERF2IP (1,161 words) [view diff] exact match in snippet view article find links to article

uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes". Molecular Cell. 12 (6): 1489–98. doi:10.1016/S1097-2765(03)00478-7

PAK6 (1,670 words) [view diff] exact match in snippet view article find links to article

phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2)". The Journal of Biological Chemistry. 288 (5): 3359–69. doi:10

Somatic evolution in cancer (9,928 words) [view diff] exact match in snippet view article find links to article

methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes". The New England Journal of Medicine. 308 (4): 199–202

Bacterial effector protein (3,272 words) [view diff] exact match in snippet view article find links to article

block apoptosis, the former by phosphorylating and stabilizing the double minute 2 protein (MDM2) which in turn leads to a block of NF-kB-induced apoptosis

Laura Niedernhofer (1,680 words) [view diff] case mismatch in snippet view article find links to article

Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes". Molecular Cell. 12 (6): 1489–1498. doi:10.1016/S1097-2765(03)00478-7

CSNK1D (14,746 words) [view diff] no match in snippet view article find links to article

kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover". Biochemistry. 43