Find link

language:

Find link is a tool written by Edward Betts.

searching for Antifolate 27 found (50 total)

alternate case: antifolate

Dihydrofolate reductase (4,585 words) [view diff] exact match in snippet view article find links to article

uses active site mutants in BaDHFR to guide lead optimization for new antifolate inhibitors. DHFR has been used as a tool to detect protein–protein interactions

Proton-coupled folate transporter (2,649 words) [view diff] exact match in snippet view article find links to article

most folates and antifolates at pH 5.5. The influx Km rises and the influx Vmax falls as the pH is increased, least so for the antifolate, pemetrexed. The

Thymidylate synthase (1,902 words) [view diff] exact match in snippet view article find links to article

3-d)pyrimidine-based Antifolate 1juj: Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate 1ypv: Structure of

Serine hydroxymethyltransferase (2,378 words) [view diff] exact match in snippet view article find links to article

already used as an antifolate to treat mesothelioma and was found to be an effective inhibitor of SHMT and screening other antifolates revealed lometrexol

Folylpolyglutamate synthase (852 words) [view diff] exact match in snippet view article find links to article

folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines". J. Biol. Chem. 275 (17): 13012–6

Timeline of cancer treatment development (2,580 words) [view diff] exact match in snippet view article find links to article

Sidney Farber induces brief remission in a patient with leukaemia with the antifolate drug aminopterin (methotrexate) 1949 – US FDA approves mechlorethamine

Folate receptor (210 words) [view diff] exact match in snippet view article find links to article

receptors reveal biological trafficking states and diversity in folate and antifolate recognition". Proceedings of the National Academy of Sciences of the United

Nolatrexed (53 words) [view diff] exact match in snippet view article find links to article

Griffin MJ, et al. (January 1999). "Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5

Formylation (2,838 words) [view diff] exact match in snippet view article find links to article

monoglutamate folates and antifolates after entering the cell for increased enzyme affinity. This increased affinity can lead to antifolate resistance. Leigh

NAS Award for Chemistry in Service to Society (656 words) [view diff] exact match in snippet view article find links to article

heterocyclic chemistry, in particular the discovery of the new-generation antifolate pemetrexed, approved for the treatment of mesothelioma and non-small cell

Folate transporter 1 (1,472 words) [view diff] exact match in snippet view article find links to article

method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated

Moses Kamya (1,572 words) [view diff] exact match in snippet view article find links to article

collector bias. Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda. Novel serologic biomarkers

Phosphoribosylglycinamide formyltransferase (1,773 words) [view diff] exact match in snippet view article find links to article

1999.1428. PMID 10577357. Costi MP, Ferrari S (June 2001). "Update on antifolate drugs targets". Current Drug Targets. 2 (2): 135–66. doi:10.2174/1389450013348669

June Biedler (2,125 words) [view diff] exact match in snippet view article find links to article

Melera, PW; Lewis, John A.; Biedler, June L.; Hession, Catherine (1980). "Antifolate-resistant Chinese Hamster Cells". Journal of Biological Chemistry. 14:

Scleroderma (3,293 words) [view diff] exact match in snippet view article find links to article

Immunoglobulin, modulates the immune system. IV N/A Varies Methotrexate Antifolate; inhibits dihydrofolate reductase. PO, IV, IM, SC, IT D (Au) Myeosuppression

FOLR2 (785 words) [view diff] exact match in snippet view article find links to article

PMID 1330883. Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells". Adv. Enzyme Regul

Nicholas J. Vogelzang (2,617 words) [view diff] exact match in snippet view article find links to article

using pemetrexed (brand name Alimta, by Eli Lilly). Pemetrexed is an antifolate, a class of drugs that targets the folic acid metabolic pathway. The results

ONX-0801 (525 words) [view diff] exact match in snippet view article find links to article

Authority. 19 July 2013. Retrieved 2017-06-03. Jarmuła A (November 2010). "Antifolate inhibitors of thymidylate synthase as anticancer drugs". Mini Reviews

Glycine (3,766 words) [view diff] exact match in snippet view article find links to article

ISBN 0-7167-4339-6. Kwon YK, Higgins MB, Rabinowitz JD (August 2010). "Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless

Kenneth Harrap (910 words) [view diff] exact match in snippet view article find links to article

305–308. doi:10.1007/BF00194534. PMID 8958186. Jamala, A. (November 2010). "Antifolate Inhibitors of Thymidylate Synthase as Anticancer Drugs". Mini-Reviews

Sidney Farber (1,720 words) [view diff] exact match in snippet view article find links to article

May 22, 1948, one of the CCRF's first patients to respond to Farber's antifolate, a twelve-year-old boy named Einar Gustafson, appeared on the show. Despite

Photopharmacology (3,790 words) [view diff] exact match in snippet view article find links to article

its photoactive cis form, phototrexate has been shown to be a potent antifolate and is relatively inactive when in the trans form. The azologization,

Reduced folate carrier family (624 words) [view diff] exact match in snippet view article find links to article

(2012-08-01). "Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide

History of cancer chemotherapy (3,824 words) [view diff] exact match in snippet view article find links to article

children with ALL. Remissions were brief, but the principle was clear — antifolates could suppress proliferation of malignant cells, and could thereby re-establish

Hereditary folate malabsorption (2,754 words) [view diff] exact match in snippet view article find links to article

transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line". Molecular Cancer Therapeutics. 8 (8): 2424–31

Toxoplasmosis (14,650 words) [view diff] exact match in snippet view article find links to article

They are treated after the first trimester because pyrimethamine has an antifolate effect, and lack of folic acid can interfere with fetal brain formation

Jim Bishop (doctor) (2,779 words) [view diff] exact match in snippet view article

S., Boyer, M. and Bishop, J 2001, 'Highly sensitive analysis of the antifolate pemetrexed sodium, a new cancer agent, in human plasma and urine by high-performance