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AKR7A2
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Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. Aldo-keto reductases, such as AKR7A2, are involvedAflatoxin total synthesis (567 words) [view diff] exact match in snippet view article find links to article
sources as part of a biological weapons program. The synthesis of racemic aflatoxin B1 has been reported by Buechi et al. in 1967 and that of racemic aflatoxinAspergillus rambellii (268 words) [view diff] exact match in snippet view article find links to article
very large amounts of sterigmatocystin, 3-O-methylsterigmatocystin and aflatoxin B1. A. rambellii has been cultivated on both Czapek yeast extract agar (CYA)Aspergillus pseudonomius (226 words) [view diff] exact match in snippet view article find links to article
the United States. It is most related to Aspergillus nomius, producing aflatoxin B1, chrysogine, and kojic acid. A. pseudonomius has been cultivated on bothIntercalation (biochemistry) (751 words) [view diff] exact match in snippet view article
often carcinogenic, such as the exo (but not the endo) 8,9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. Intercalation as a mechanismAspergillus pseudotamarii (152 words) [view diff] exact match in snippet view article find links to article
The species was first described in 2001. It has been shown to produce aflatoxin B1, aflatoxin B2, cyclopiazonic acid, and kojic acid. A. pseudotamarii hasOlumbe Bassir (1,222 words) [view diff] exact match in snippet view article find links to article
content of fresh leaves and wilted leaves. 1970 - Oxidative metabolism of aflatoxin B1 by mammalian liver slices and microsomes. 1979 - The uncoupling effectAspergillus miraensis (199 words) [view diff] exact match in snippet view article find links to article
var. stenophyllum, in Tibet, China. It has been reported to produce aflatoxin B1. A. miraensis has been cultivated on both Czapek yeast extract agar (CYA)2013 European aflatoxin contamination (657 words) [view diff] exact match in snippet view article find links to article
Alert System for Food and Feed (RASFF) has reported 10 notifications of aflatoxin B1 in maize of European origin since the last maize harvest in autumn 2012George Tawia Odamtten (1,405 words) [view diff] exact match in snippet view article find links to article
Link NRRL 5906, 1980; (contrib.) IFFIT Report No. 13 – Production of Aflatoxin B1 by Aspergillus Flavus Link in Submerged Static Culture After CombinationBioenhancer (2,375 words) [view diff] exact match in snippet view article find links to article
drugs such as phenytoin, theophylline, propanolol and a toxin called aflatoxin B1. Increased Bioavailabiity means increased levels of drug in the bloodCopra (1,488 words) [view diff] exact match in snippet view article find links to article
December 2019. Tosun, Halil; Arslan, Recep (2013). "Determination of Aflatoxin B1 Levels in Organic Spices and Herbs". The Scientific World Journal. 2013:Aldo-keto reductase family 1, member A1 (1,630 words) [view diff] exact match in snippet view article find links to article
differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 familyMycobacterium fluoranthenivorans (95 words) [view diff] exact match in snippet view article find links to article
2004. Mycobacterium fluoranthenivorans sp. nov., a fluoranthene and aflatoxin B1 degrading bacterium from contaminated soil of a former coal gas plantCellulosimicrobium funkei (257 words) [view diff] exact match in snippet view article find links to article
novel strain of Cellulosimicrobium funkei can biologically detoxify aflatoxin B1 in ducklings". Microbial Biotechnology. 8 (3): 490–498. doi:10.1111/1751-7915AKR7A3 (118 words) [view diff] exact match in snippet view article find links to article
overview of all the structure information available in the PDB for Human Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) This article incorporates text fromAKR1C1 (1,146 words) [view diff] exact match in snippet view article find links to article
differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 familyAlbert P. Li (1,516 words) [view diff] exact match in snippet view article find links to article
metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. Chem Biol Interact. 179(1), 4–8. Li, A. P. and Doshi U. (2011) HigherMycotoxicology (2,586 words) [view diff] exact match in snippet view article find links to article
relative chromatographic mobility during thin-layer chromatography. Aflatoxin B1 is the most potent natural carcinogen known and is usually the majorEbenezer Olatunde Farombi (621 words) [view diff] exact match in snippet view article find links to article
nontarget Nauphoeta cinerea nymphs Cellular and molecular mechanisms of aflatoxin B1-mediated neurotoxicity: The therapeutic role of natural bioactive compoundsSugarcane juice (1,381 words) [view diff] exact match in snippet view article find links to article
Egypt may pose health risks due to contamination with the mycotoxins, aflatoxin B1 and fumonisin B1. Sugarcane juice, known locally as caldo de cana, orButylated hydroxytoluene (2,934 words) [view diff] exact match in snippet view article find links to article
Egner, PA; Trush, MA; Bueding, E; Groopman, JD (1985). "Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquinT. A. Venkitasubramanian (904 words) [view diff] exact match in snippet view article find links to article
A.; Raj H. G. (November 1986). "Changes in liver polyamines due to aflatoxin B1". Toxicol Lett. 34 (1): 1–4. doi:10.1016/0378-4274(86)90138-4. PMID 3097877Median lethal dose (4,276 words) [view diff] exact match in snippet view article find links to article
Meister Pub Co. p. 664. ISBN 978-1892829269. "Safety (MSDS) data for aflatoxin B1". ox.ac.uk. Archived from the original on 2010-08-11. Voelz GL, BuicanFinrozole (49 words) [view diff] exact match in snippet view article find links to article
Huuskonen, P; Myllynen, P; Storvik, M; Pasanen, M (2013). "The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells". ToxicologyCYP2A6 (1,131 words) [view diff] exact match in snippet view article find links to article
Inhibitors Inducers Many Carcinogens MNAN NNK NDEA MTBE Other toxins aflatoxin B1 (mycotoxin) 1,3-butadiene (in synthetic rubber) coumarin (anticoagulantCadmium-free quantum dot (2,247 words) [view diff] exact match in snippet view article find links to article
is the detection of food toxins including the harmful toxin, aflatoxin- B1. Aflatoxin B1 is a very toxic compound that can cause serious and permanentSterigmatocystin 8-O-methyltransferase (181 words) [view diff] exact match in snippet view article find links to article
LS, Hill RA (1987). "Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus". Appl. Environ. MicrobiolPhytoalexin (1,762 words) [view diff] exact match in snippet view article find links to article
phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1". Cancer Lett. 59 (2): 89–94. doi:10.1016/0304-3835(91)90171-D. PMID 1909211Oncom (592 words) [view diff] exact match in snippet view article find links to article
growth of Aspergillus flavus and A. parasiticus and accumulation of aflatoxin B1 in groundnut". Mycological Research. 93 (4): 518–523. doi:10.1016/S0953-7562(89)80046-2National Institute of Molecular Biology and Biotechnology (749 words) [view diff] exact match in snippet view article find links to article
The laboratory can determine the concentrations of the mycotoxins, aflatoxin B1 and M1, ochratoxin A, zearalenone, fumonisin and red tide toxins to asAKR1B1 (1,825 words) [view diff] exact match in snippet view article find links to article
differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 familySimplified Molecular Input Line Entry System (3,645 words) [view diff] exact match in snippet view article find links to article
CC1=C(C(=O)C[C@@H]1OC(=O)[C@@H]2[C@H](C2(C)C)/C=C(\C)/C(=O)OC)C/C=C\C=C Aflatoxin B1 (C17H12O6) O1C=C[C@H]([C@H]1O2)c3c2cc(OC)c4c3OC(=O)C5=C4CCC(=O)5 GlucoseRhizopus oligosporus (1,104 words) [view diff] exact match in snippet view article find links to article
growth of Aspergillus flavus and A. parasiticus and accumulation of aflatoxin B1 in groundnut". Mycological Research. 93 (4): 518–523. doi:10.1016/s0953-7562(89)80046-2Ribosomal protein SA (2,584 words) [view diff] exact match in snippet view article find links to article
in vitro. RPSA is also a receptor for small molecules. (i) RPSA binds aflatoxin B1 both in vivo and in vitro. (ii) RPSA is a receptor for epigallocatechin-gallateCYP1A2 (2,813 words) [view diff] exact match in snippet view article find links to article
intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and paracetamol (acetaminophen). The transcript from this gene containsABCC1 (1,849 words) [view diff] exact match in snippet view article find links to article
transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfateAspergillus flavus (2,927 words) [view diff] exact match in snippet view article find links to article
of the major toxins is a result of particular strains of A. flavus. Aflatoxin B1 is the most toxic and potent hepatocarcinogenic natural compound characterizedMycotoxin (4,558 words) [view diff] exact match in snippet view article find links to article
different types of mycotoxins produced, which are B1, B2, G1, and G2. Aflatoxin B1, the most toxic, is a potent carcinogen and has been directly correlatedEliezer Huberman (1,567 words) [view diff] exact match in snippet view article find links to article
Huberman, Eliezer (1978). "Cell specificity in metabolic activation of aflatoxin B1 and benzo(a)pyrene to mutagens for mammalian cells". Nature. 276 (5685):Carcinogen (4,577 words) [view diff] exact match in snippet view article find links to article
causes cancer as a "myth". Several biologic agents are known carcinogens. Aflatoxin B1, a toxin produced by the fungus Aspergillus flavus which is a commonEconomic botany (3,278 words) [view diff] exact match in snippet view article find links to article
Liver Histopathology and Aflatoxin Residues in Broilers Exposed to Aflatoxin B1". Toxins. 9 (11): 371. doi:10.3390/toxins9110371. PMC 5705986. PMID 29140290Cytochrome P450 (individual enzymes) (4,497 words) [view diff] exact match in snippet view article
in terms of their kinetic properties as well as in the metabolism of aflatoxin B1. CYPs have also been extensively studied in insects, often to understandCitrinin (4,183 words) [view diff] exact match in snippet view article find links to article
Citrinin often occurs together with other mycotoxins like ochratoxin A or aflatoxin B1, because they are produced by the same fungi species. The combinationNeosaxitoxin (5,254 words) [view diff] exact match in snippet view article find links to article
Gabliks J, Barter S (April–September 1987). "Comparative cytotoxicity of aflatoxin B1 and saxitoxin in cell cultures". Molecular Toxicology. 1 (2–3): 209–16Liver cancer (6,080 words) [view diff] exact match in snippet view article find links to article
S2CID 20842446. Dai Y, Huang K, Zhang B, Zhu L, Xu W (November 2017). "Aflatoxin B1-induced epigenetic alterations: An overview". Food and Chemical ToxicologyC3orf62 (1,233 words) [view diff] exact match in snippet view article find links to article
MFRAP1). Chemicals known to interact with C3orf62 include the following: Aflatoxin B1, Hydralazine, Valproic acid, and Decitabine. Interstitial deletions ofPeanut (7,732 words) [view diff] exact match in snippet view article find links to article
ISBN 978-1-84826-368-0. Hirano, S; Shima, T; Shimada, T (August 2001). "[Proportion of aflatoxin B1 contaminated kernels and its concentration in imported peanut samples]"Almond (7,069 words) [view diff] exact match in snippet view article find links to article
Retrieved 23 August 2012. Rushing, Blake R.; Selim, Mustafa I. (2019). "Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposureCYP3A4 (7,794 words) [view diff] exact match in snippet view article find links to article
increases when in the presence of CYP3A4 ligands, such as in the presence of aflatoxin B1, M1, and G1. Indeed, due to the enzyme's large and malleable active siteFoodborne illness (7,699 words) [view diff] exact match in snippet view article find links to article
pronounced forms of aflatoxins are those of B1, B2, G1, and G2, amongst which Aflatoxin B1 predominantly targets the liver, which will result in necrosis, cirrhosisConocephalum (3,491 words) [view diff] exact match in snippet view article find links to article
Chemical structure of aflatoxin B1 found in Aspergillus fungiMold health issues (5,871 words) [view diff] exact match in snippet view article find links to article
Mycotoxins may also contribute to cancer. Dietary exposure to the mycotoxin aflatoxin B1, commonly produced by growth of the fungus Aspergillus flavus on improperlyGNMT (3,150 words) [view diff] exact match in snippet view article find links to article
(March 2009). "Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect". Toxicology and Applied PharmacologyEPHX1 (2,998 words) [view diff] exact match in snippet view article find links to article
associated with genetic variation in the enzymatic detoxification of aflatoxin B1". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2384–7. Bibcode:1995PNAS...92Curtis C. Harris (2,468 words) [view diff] exact match in snippet view article find links to article
the first-known molecular link between an environmental carcinogen, aflatoxin B1, and a specific mutation at codon 249 of the p53-encoding TP53 gene inWilliam A. Haseltine (12,622 words) [view diff] exact match in snippet view article find links to article
PMID 80799. D'Andrea, AD; Haseltine WA (1978). "Modification of DNA by Aflatoxin B1 Creates Alkali-Labile Lesions in DNA at Positions of Guanine and Adenine"