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searching for CYP1A2 45 found (225 total)

alternate case: cYP1A2

Glucuronidation (544 words) [view diff] exact match in snippet view article find links to article

paracetamol, oxazepam, temazepam, and propranolol. Possible additive role with CYP1A2 resulting in higher clozapine and olanzapine concentrations in females Males

Guanoxabenz (38 words) [view diff] exact match in snippet view article find links to article

of guanoxabenz from guanabenz in human liver. A new metabolic marker for CYP1A2". Drug Metabolism and Disposition. 25 (11): 1266–1271. PMID 9351903. v t

Norfloxacin (4,599 words) [view diff] exact match in snippet view article find links to article

norfloxacin, have been shown in vitro to inhibit CYP1A2. Concomitant use with drugs metabolized by CYP1A2 (e.g., caffeine, clozapine, ropinirole, tacrine

Kavalactone (880 words) [view diff] exact match in snippet view article find links to article

and herbal medications. In human volunteers, in vivo inhibition includes CYP1A2 and CYP2E1 through use of probe drugs to measure inhibition. Its anxiolytic

Lobeglitazone (582 words) [view diff] exact match in snippet view article find links to article

lobeglitazone was a substrate of rodent OATP1B2. Lobeglitazone interacted with CYP1A2, 2C9 and 2C19. Distribution to liver of lobeglitazone was inhibited by atorvastatin

Anagrelide (877 words) [view diff] exact match in snippet view article find links to article

℞-only EU: Rx-only Pharmacokinetic data Metabolism Liver, partially through CYP1A2 Elimination half-life 1.3 hours Excretion Urine (<1%) Identifiers IUPAC

Nabumetone (766 words) [view diff] exact match in snippet view article find links to article

Three step CYP1A2 Mediated Metabolism of the prodrug Nabumetone to its active metabolite 6-MNA.

Discovery and development of triptans (2,837 words) [view diff] exact match in snippet view article find links to article

tablets Nasal spray 2.5, 5 2.5, 5 2.5, 5 10 10 10 45 – 10–15 Short 9.2 CYP1A2 MAO-A Urine (65%), Feces (30%) Naratriptan Tablets 1, 2.5 5 60–180 Long

Umbralisib (1,275 words) [view diff] exact match in snippet view article find links to article

℞-only / withdrawn Pharmacokinetic data Metabolism CYP2C9, CYP3A4, and CYP1A2 Elimination half-life 91 h Excretion Feces, urine Identifiers IUPAC name

Benzhydrocodone (1,175 words) [view diff] exact match in snippet view article find links to article

glucuronide conjugation, sulfate conjugation or oxidation. The CYP450 dependent (CYP1A2, CYP2E1, and CYP3A4) oxidation pathway produces a reactive metabolite that

Butabarbital (1,576 words) [view diff] exact match in snippet view article find links to article

Half-Life: ~100 hr Duration: 6-8 hr Onset: 45-60 min Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4 Excretion: Urine The mechanism of action by which barbiturates

Paraxanthine (1,709 words) [view diff] exact match in snippet view article find links to article

which is subsequently demethylated into xanthine or oxidized by CYP2A6 and CYP1A2 into 1,7-dimethyluric acid. In another pathway, paraxanthine is broken down

Flavin-containing monooxygenase 3 (2,500 words) [view diff] exact match in snippet view article find links to article

form 6-OH-MXAA, but plays a lesser important role for this reaction than CYP1A2 that has been demonstrated to catalyse 6-OH-MXAA formation. Tang WH, Hazen

Trospium chloride (2,095 words) [view diff] exact match in snippet view article find links to article

inhibitory effect of trospium on seven cytochrome P450 isoenzyme substrates (CYP1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) suggest a lack of inhibition at clinically

Quercetin (2,467 words) [view diff] exact match in snippet view article find links to article

Metabolism of Caffeine, a Substrate of Cytochrome P450 1A2 Unrelated to CYP1A2*1C (−2964G>A) and 1F* (734C>A) Gene Polymorphisms". BioMed Research International

Levobupivacaine (2,303 words) [view diff] exact match in snippet view article find links to article

biotransformation in the liver by the cytochrome P450 enzyme, specifically CYP1A2 and CYP3A isoforms as part of phase one biotransformation, thereby producing

Myristicin (1,355 words) [view diff] exact match in snippet view article find links to article

reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2". Chemico-Biological Interactions. 237: 133–40. Bibcode:2015CBI...237..133Y

Ilya B. Tsyrlov (1,341 words) [view diff] exact match in snippet view article find links to article

preferred tests for major medical conditions. Tsyrlov revealed that human CYP1A2 is the catalyst of ethanol and uroporphyrinogen oxidation. Tsyrlov and Andrey

Landiolol (2,807 words) [view diff] exact match in snippet view article find links to article

the metabolic activity of different cytochrome P450 molecular species (CYP1A2, 2C9, 2C19, 2D6 and 3A4) in vitro. The cytochrome P450 content was not affected

USF2 (1,255 words) [view diff] exact match in snippet view article find links to article

upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation".

Tardive dyskinesia (3,909 words) [view diff] exact match in snippet view article find links to article

(May 2003). "Smoking and tardive dyskinesia: lack of involvement of the CYP1A2 gene". J Psychiatry Neurosci. 28 (3): 185–189. PMC 161742. PMID 12790158

Moxifloxacin (3,394 words) [view diff] exact match in snippet view article find links to article

that moxifloxacin does not inhibit 80 CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2, suggesting that moxifloxacin is unlikely to alter the pharmacokinetics

Aconitine (3,635 words) [view diff] exact match in snippet view article find links to article

2D6. CYP2C8 and 2C9 had a minor role to the aconitine metabolism, whereas CYP1A2, 2E1 and 2C19 did not produce any aconitine metabolites at all. The proposed

Bromazepam (4,290 words) [view diff] exact match in snippet view article find links to article

Pharmacology in Weesp reported that fluvoxamine, which is a potent inhibitor of CYP1A2, a less potent CYP3A4 inhibitor, and a negligible inhibitor of CYP2D6, does

Cariprazine (3,118 words) [view diff] exact match in snippet view article find links to article

metabolism by CYP2D6. Cariprazine does not induce the production of CYP3A4 or CYP1A2 in the liver, and weakly, competitively inhibits CYP2D6 and CYP3A4. Positive

USF1 (4,538 words) [view diff] exact match in snippet view article find links to article

upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation".

Dioxins and dioxin-like compounds (10,768 words) [view diff] exact match in snippet view article find links to article

include both oxidative phase I enzymes and conjugative phase II enzymes, e.g. CYP1A2, CYP1B1, CYP2S1, CYP2A5, ALDH3, GSTA1, UGT1A1, UGT1A6, UGT1A7 and NQO1.

COX5A (988 words) [view diff] exact match in snippet view article find links to article

"Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption". PLOS Genetics. 7 (4):

Resazurin (1,886 words) [view diff] exact match in snippet view article find links to article

Waxman, David J. (2005). "Enzymatic Analysis of cDNA-Expressed Human CYP1A1, CYP1A2, and CYP1B1 With 7-Ethoxyresorufin as Substrate". In Phillips, I.R.; Shephard

Laurdan (1,632 words) [view diff] exact match in snippet view article find links to article

Brignac-Huber, L.M; Reed, JR.; Eyer, MK.; Backes, WL. (2013). "Relationship between CYP1A2 Localization and Lipid Microdomain Formation as a Function of Lipid Composition"

Eicosanoid (9,651 words) [view diff] exact match in snippet view article find links to article

oxidation reaction. The human cytochrome P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize

Medical cannabis (10,310 words) [view diff] exact match in snippet view article find links to article

primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. Similar to delta-9-THC, a majority of CBD is excreted

LiMAx test (805 words) [view diff] exact match in snippet view article find links to article

Zaigler, M. and Rietbrock, S. and Fuhr, U. Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test. Pharmacogenetics

Adenosine diphosphate receptor inhibitor (5,282 words) [view diff] exact match in snippet view article find links to article

activation to produce the active metabolite that inhibits the P2Y12 receptor. CYP1A2, CYP3A4, CYP3A5 and CYP2C19 are considered to be the main enzymes involved

Caffeine-induced psychosis (998 words) [view diff] exact match in snippet view article find links to article

worsening the symptoms of schizophrenia. "Caffeine is metabolized by the CYP1A2 enzyme and also acts as a competitive inhibitor of this enzyme. Thus, caffeine

Management of Parkinson's disease (8,902 words) [view diff] exact match in snippet view article find links to article

undergoes extensive hepatic metabolism primarily by cytochrome P450 type 1A2 (CYP1A2). Rasagiline is initiated at 1-mg once-daily dose as monotherapy in early

Selegiline (20,330 words) [view diff] exact match in snippet view article find links to article

CYP2A6 substrate). By inhibiting cytochrome P450 enzymes like CYP2B6 and CYP1A2, selegiline may inhibit its own metabolism and thereby interact with itself

Health effects of tobacco (22,285 words) [view diff] exact match in snippet view article find links to article

smokers, which may result in the drugs not working. Specifically, levels of CYP1A2 and CYP2A6 are induced: substrates for 1A2 include caffeine and tricyclic

Discovery and development of direct Xa inhibitors (4,916 words) [view diff] exact match in snippet view article find links to article

Apixaban Edoxaban Metabolism CYP3A4/5 (major), CYP2J2 (minor) CYP3A4 (major), CYP1A2, 2C8, 2C19, 2J2 (all minor) CYP34A (major) Protein binding (%) 92–95 87

Development and discovery of SSRI drugs (5,336 words) [view diff] exact match in snippet view article find links to article

(36%) (via the bile) Fluvoxamine 3–8 50 25 77–80 15.6 hours Hepatic by CYP1A2 and CYP3A4 No clinically important metabolites Mainly urine Citalopram 2–4

Tedral (2,020 words) [view diff] exact match in snippet view article find links to article

Barbiturates Benzodiazepines Bupropion Beta-2 agonists Beta blockers CYP1A2 inhibitors CYP1A2 inducers Cambendazole Clarithromycin Erythromycin Interleukin-6

Muse cell (8,806 words) [view diff] exact match in snippet view article find links to article

with host hepatocytes, and express mature functional markers such as human CYP1A2 (detoxification enzyme) and human Glc-6-Pase (enzyme for glucose metabolism)

6-Formylindolo(3,2-b)carbazole (4,634 words) [view diff] exact match in snippet view article

is an excellent CYP1A1 substrate, but is also a very good substrate for CYP1A2 and CYP1B1. The mono- and di-hydroxylated metabolites of FICZ are subject

Bruce Pollock (2,016 words) [view diff] exact match in snippet view article find links to article

that estradiol significantly reduced caffeine metabolic ratios, revealing CYP1A2 inhibition. Pollock worked with Reynolds on several clinical trials, investigating

Evolutionary models of human drug use (6,499 words) [view diff] exact match in snippet view article find links to article

mediated influences. Specifically, changes in hepatic drug elimination for CYP1A2, CYP2C19 and CYP2A6 are similar in pregnant women and non-pregnant women