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searching for lRRK2 25 found (55 total)

alternate case: LRRK2

Valina L. Dawson (3,374 words) [view diff] exact match in snippet view article find links to article

LRRK2 increase its kinase activity and that inhibition of LRRK2 kinase activity is protective in models of Parkinson's disease. The increase in LRRK2

Ted M. Dawson (2,746 words) [view diff] exact match in snippet view article find links to article

that inhibiting LRRK2 kinase activity is protective. In collaborative studies, they identified Rab35 as the key Rab linked to LRRK2 neurotoxicity. Their

Epigenetic regulation of neurogenesis (5,725 words) [view diff] exact match in snippet view article find links to article

to the 3′ UTR of LRRK2 mRNA and suppress expression, as well as miR-205's prevention of defects after introduction to a R1441G LRRK2 mutation, these results

Rab (G-protein) (1,327 words) [view diff] exact match in snippet view article

Small-scale transport, promoter for tumor development RAB27 Extracellular vesicles, endosome RAB29 Recruits LRRK2 to TGN RAB39A Binds Caspase-1 in inflammasome

Expedition 53 (1,833 words) [view diff] exact match in snippet view article find links to article

microgravity, the CASIS PCG7 study, which grew larger versions of the protein LRRK2 to help study Parkinson's disease, and mice from the Rodent Research-9 study

Diapocynin (164 words) [view diff] exact match in snippet view article find links to article

early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse". Neuroscience Letters. 549: 57–62. doi:10.1016/j

Vernalis Research (1,160 words) [view diff] exact match in snippet view article find links to article

Chen IJ, et al. (November 2017). "Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase

Dimitri Krainc (1,333 words) [view diff] exact match in snippet view article find links to article

Nguyen, M., Young, T, Severino, A., Schwake, M., Merchant, K., Krainc, D. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in Parkinson’s Disease

LRRK1 (587 words) [view diff] exact match in snippet view article find links to article

PMID 17353931. Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent

Sonia Gandhi (scientist) (865 words) [view diff] exact match in snippet view article

at the Francis Crick Institute. Gandhi's publications include: A common LRRK2 mutation in idiopathic Parkinson's disease Mechanism of Oxidative Stress

Phosphomimetics (837 words) [view diff] exact match in snippet view article find links to article

Valina L Dawson (2014). "Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease". Cell. 157 (2): 472–485. doi:10

Breakthrough Prize in Life Sciences (351 words) [view diff] exact match in snippet view article find links to article

Van Goor United States Thomas Gasser Germany "For identifying GBA1 and LRRK2 as risk genes for Parkinson's disease, implicating autophagy and lysosomal

Jenny Vaughan (879 words) [view diff] exact match in snippet view article find links to article

Shushant Jain; John M Lynch; et al. (4 November 2005). "Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical,

Parkinson's disease (17,589 words) [view diff] exact match in snippet view article find links to article

Major genetic risk factors that do not contribute to Lewy bodies include LRRK2 and PRKN. Although the vast majority or Parkinson's cases are believed to

Target 2035 (1,127 words) [view diff] exact match in snippet view article find links to article

hit-finding. The first competition - finding ligands for the WD40 domain of LRRK2 - started in March 2022. The first round of predictions have been submitted

CKMT1A (969 words) [view diff] exact match in snippet view article find links to article

Yue Z, Xu Z (October 2011). "Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture

Sharon Tooze (619 words) [view diff] exact match in snippet view article find links to article

independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition". Bioscience Reports. 38 (2): BSR20171669. doi:10.1042/BSR20171669

PAK6 (1,650 words) [view diff] exact match in snippet view article find links to article

junctional protein IQGAP1, E3 ligase Mdm2, and leucine-rich repeat kinase 2 (LRRK2). PAK6 has been shown to interact with Androgen receptor. GRCh38: Ensembl

Protein targeting (6,394 words) [view diff] exact match in snippet view article find links to article

Di Paolo G, McCabe BD, et al. (February 2013). "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk". Neuron

Cyclin-dependent kinase 5 (5,356 words) [view diff] exact match in snippet view article find links to article

talin, drebrin, synapsin I, synapsin III, CRMP1, GKAP, SPAR, PSD-95, and LRRK2. The mammalian circadian clock is controlled by Cdk5 with the phosphorylation

C17orf53 (1,349 words) [view diff] exact match in snippet view article find links to article

proteins bearing a leucine-rich nuclear export signal (NES) and of RNAs LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 association 0.35 Anti

FAM71E1 (1,226 words) [view diff] exact match in snippet view article find links to article

Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations". PLOS ONE. 11 (5): e0154890. Bibcode:2016PLoSO

Edna Schechtman (1,626 words) [view diff] exact match in snippet view article find links to article

I., Gershoni-Baruch, R., Djaldetti, R., ... & Inzelberg, L. (2012). The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin

Chaperone-mediated autophagy (3,623 words) [view diff] exact match in snippet view article find links to article

Consiglio, A; Raya, A; Sulzer, D; Cuervo, AM (April 2013). "Interplay of LRRK2 with chaperone-mediated autophagy". Nature Neuroscience. 16 (4): 394–406

Epigenetics of neurodegenerative diseases (13,392 words) [view diff] exact match in snippet view article find links to article

the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and fibrillar accumulation of Lewy bodies from misfolded alpha-synuclein