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Find link is a tool written by Edward Betts.searching for lRRK2 25 found (55 total)
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Valina L. Dawson
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LRRK2 increase its kinase activity and that inhibition of LRRK2 kinase activity is protective in models of Parkinson's disease. The increase in LRRK2Ted M. Dawson (2,746 words) [view diff] exact match in snippet view article find links to article
that inhibiting LRRK2 kinase activity is protective. In collaborative studies, they identified Rab35 as the key Rab linked to LRRK2 neurotoxicity. TheirEpigenetic regulation of neurogenesis (5,725 words) [view diff] exact match in snippet view article find links to article
to the 3′ UTR of LRRK2 mRNA and suppress expression, as well as miR-205's prevention of defects after introduction to a R1441G LRRK2 mutation, these resultsRab (G-protein) (1,327 words) [view diff] exact match in snippet view article
Small-scale transport, promoter for tumor development RAB27 Extracellular vesicles, endosome RAB29 Recruits LRRK2 to TGN RAB39A Binds Caspase-1 in inflammasomeExpedition 53 (1,833 words) [view diff] exact match in snippet view article find links to article
microgravity, the CASIS PCG7 study, which grew larger versions of the protein LRRK2 to help study Parkinson's disease, and mice from the Rodent Research-9 studyDiapocynin (164 words) [view diff] exact match in snippet view article find links to article
early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse". Neuroscience Letters. 549: 57–62. doi:10.1016/jVernalis Research (1,160 words) [view diff] exact match in snippet view article find links to article
Chen IJ, et al. (November 2017). "Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint KinaseDimitri Krainc (1,333 words) [view diff] exact match in snippet view article find links to article
Nguyen, M., Young, T, Severino, A., Schwake, M., Merchant, K., Krainc, D. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in Parkinson’s DiseaseLRRK1 (587 words) [view diff] exact match in snippet view article find links to article
PMID 17353931. Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalentSonia Gandhi (scientist) (865 words) [view diff] exact match in snippet view article
at the Francis Crick Institute. Gandhi's publications include: A common LRRK2 mutation in idiopathic Parkinson's disease Mechanism of Oxidative StressPhosphomimetics (837 words) [view diff] exact match in snippet view article find links to article
Valina L Dawson (2014). "Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease". Cell. 157 (2): 472–485. doi:10Breakthrough Prize in Life Sciences (351 words) [view diff] exact match in snippet view article find links to article
Van Goor United States Thomas Gasser Germany "For identifying GBA1 and LRRK2 as risk genes for Parkinson's disease, implicating autophagy and lysosomalJenny Vaughan (879 words) [view diff] exact match in snippet view article find links to article
Shushant Jain; John M Lynch; et al. (4 November 2005). "Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical,Parkinson's disease (17,589 words) [view diff] exact match in snippet view article find links to article
Major genetic risk factors that do not contribute to Lewy bodies include LRRK2 and PRKN. Although the vast majority or Parkinson's cases are believed toTarget 2035 (1,127 words) [view diff] exact match in snippet view article find links to article
hit-finding. The first competition - finding ligands for the WD40 domain of LRRK2 - started in March 2022. The first round of predictions have been submittedCKMT1A (969 words) [view diff] exact match in snippet view article find links to article
Yue Z, Xu Z (October 2011). "Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell cultureSharon Tooze (619 words) [view diff] exact match in snippet view article find links to article
independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition". Bioscience Reports. 38 (2): BSR20171669. doi:10.1042/BSR20171669PAK6 (1,650 words) [view diff] exact match in snippet view article find links to article
junctional protein IQGAP1, E3 ligase Mdm2, and leucine-rich repeat kinase 2 (LRRK2). PAK6 has been shown to interact with Androgen receptor. GRCh38: EnsemblProtein targeting (6,394 words) [view diff] exact match in snippet view article find links to article
Di Paolo G, McCabe BD, et al. (February 2013). "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk". NeuronCyclin-dependent kinase 5 (5,356 words) [view diff] exact match in snippet view article find links to article
talin, drebrin, synapsin I, synapsin III, CRMP1, GKAP, SPAR, PSD-95, and LRRK2. The mammalian circadian clock is controlled by Cdk5 with the phosphorylationC17orf53 (1,349 words) [view diff] exact match in snippet view article find links to article
proteins bearing a leucine-rich nuclear export signal (NES) and of RNAs LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 association 0.35 AntiFAM71E1 (1,226 words) [view diff] exact match in snippet view article find links to article
Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations". PLOS ONE. 11 (5): e0154890. Bibcode:2016PLoSOEdna Schechtman (1,626 words) [view diff] exact match in snippet view article find links to article
I., Gershoni-Baruch, R., Djaldetti, R., ... & Inzelberg, L. (2012). The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skinChaperone-mediated autophagy (3,623 words) [view diff] exact match in snippet view article find links to article
Consiglio, A; Raya, A; Sulzer, D; Cuervo, AM (April 2013). "Interplay of LRRK2 with chaperone-mediated autophagy". Nature Neuroscience. 16 (4): 394–406Epigenetics of neurodegenerative diseases (13,392 words) [view diff] exact match in snippet view article find links to article
the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and fibrillar accumulation of Lewy bodies from misfolded alpha-synuclein