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Cellular neuroscience
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Several techniques such as intracellular recording, patch-clamp, and voltage-clamp technique, pharmacology, confocal imaging, molecular biology, two photonSquid giant axon (643 words) [view diff] exact match in snippet view article find links to article
experimental advantage for Hodgkin and Huxley as it allowed them to insert voltage clamp electrodes inside the lumen of the axon. While the squid axon is veryAccommodation index (382 words) [view diff] exact match in snippet view article find links to article
spike train data. Many methods of experimental neuroscience, such as voltage clamp recordings, give their output in the form of measured voltages of individualKCNJ15 (783 words) [view diff] exact match in snippet view article find links to article
resulted in 6-fold increase in K+ current. Two years later, in 1999, voltage clamp measurements in xenopus oocytes found that intracellular acidificationSquid giant synapse (921 words) [view diff] exact match in snippet view article find links to article
"Presynaptic calcium currents and their relation to synaptic transmission. Voltage clamp study in the squid giant synapse and theoretical model for the calciumRodolfo Llinás (3,001 words) [view diff] exact match in snippet view article find links to article
nucleus). First determination of presynaptic calcium current, under voltage clamp, at the squid giant synapse. Discovery that vertebrate neurons (cerebellarAlan Finkel (2,067 words) [view diff] case mismatch in snippet view article find links to article
revolutionary measurement approach – the Discontinuous Single-Electrode Voltage Clamp. Axon Instruments In 1983, Finkel founded Axon Instruments Inc, in SiliconVoltammetry (3,156 words) [view diff] exact match in snippet view article find links to article
Stewart Cole invented an electronic circuit which he called a voltage clamp. The voltage clamp was used to analyze the ionic conduction in nerves. The 1960sErythromelalgia (6,123 words) [view diff] exact match in snippet view article find links to article
in The Journal of Neuroscience, Cummins et al., demonstrated, using voltage clamp recordings, that these mutations enhanced the function of NaV1.7 sodiumLawrence B. Salkoff (1,569 words) [view diff] exact match in snippet view article find links to article
system. To this end, as a postdoctoral researcher, Salkoff adapted the voltage clamp technique to the fruit fly Drosophila which had been used by Alan LloydKurtoxin (468 words) [view diff] no match in snippet view article find links to article
channel gating. The effect of the toxin is voltage-dependent. In a voltage-clamp experiment, it was found that calcium channels are more strongly inhibitedSLC13A3 (562 words) [view diff] no match in snippet view article find links to article
the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions". Am. J. Physiol. Renal Physiol. 288 (4): F792–9. doi:10Soliton model in neuroscience (3,686 words) [view diff] exact match in snippet view article find links to article
special case of such solitary waves. Ionic currents under voltage clamp The voltage clamp, used by Hodgkin and Huxley (1952) (Hodgkin-Huxley Model) toDesformylflustrabromine (829 words) [view diff] exact match in snippet view article find links to article
α4β2 nicotinic acetylcholine receptor responses by using two-electrode voltage clamp whole cell recordings. In the year 2002 it was reported that dFBr wasMorris–Lecar model (992 words) [view diff] exact match in snippet view article find links to article
Columbia University in 1963. The Morris–Lecar experiments relied on the voltage clamp method established by Keynes et al. (1973). Large specimens of the barnacleNorthern leopard frog (1,775 words) [view diff] exact match in snippet view article find links to article
1287. PMC 2225709. PMID 6033586. Anderson, CR; Stevens, CF (1973). "Voltage clamp analysis of acetylcholine produced end-plate current fluctuations atUCL Neuroscience (1,577 words) [view diff] no match in snippet view article find links to article
action potentials along nerve fibres. To achieve this, they developed a voltage-clamp technique to demonstrate that impulse transmission relied upon the selectiveDelta atracotoxin (2,268 words) [view diff] no match in snippet view article find links to article
activity of this potent neurotoxin on voltage-gated sodium channels. Under voltage-clamp conditions in dorsal root ganglion (DRG) neurons it was found that theJoro toxin (358 words) [view diff] no match in snippet view article find links to article
Yoshinori; Robinson, Hugh P.C.; Miwa, Akiko; Kawai, Nobufumi (1991). "A voltage-clamp study of the effects of Joro spider toxin and zinc on excitatory synapticQuantitative models of the action potential (3,134 words) [view diff] no match in snippet view article find links to article
Andrew Huxley developed a set of equations to fit their experimental voltage-clamp data on the axonal membrane. The model assumes that the membrane capacitanceFrederick Sachs (891 words) [view diff] exact match in snippet view article find links to article
cause of a disease. Beyond spider venom, Sachs also conducted the first voltage clamp studies of isolated adult heart cells. He was also responsible for thePerampanel (1,484 words) [view diff] exact match in snippet view article find links to article
was the first drug of this class approved for epilepsy. Whole-cell voltage clamp studies have demonstrated that perampanel is a negative allosteric AMPANeural backpropagation (2,262 words) [view diff] exact match in snippet view article find links to article
Since artificial LTP induction, using microelectrode stimulation, voltage clamp, etc. requires the postsynaptic cell to be slightly depolarized whenMagnesium in biology (10,110 words) [view diff] no match in snippet view article find links to article
capacity is added to the cells. Second, the technique of two-electrode voltage-clamp allows the direct measurement of the ion flux across the membrane ofRepolarization (2,413 words) [view diff] no match in snippet view article find links to article
microsecond action potentials that requires quick repolarization. Utilizing voltage-clamp data from experiments based on rodent neurons, the Kv4 channels areIzon Science (1,352 words) [view diff] exact match in snippet view article find links to article
components for controlling pressure and nanopore stretch, and an enhanced voltage clamp amplifier. The qNano required manual tuning to adjust the stretch ofDonhee Ham (1,644 words) [view diff] no match in snippet view article find links to article
"The design of a CMOS nanoelectrode array with 4096 current-clamp/voltage-clamp amplifiers for intracellular recording/stimulation of mammalian neurons"Operational amplifier applications (4,518 words) [view diff] exact match in snippet view article find links to article
current regulator analog-to-digital converter digital-to-analog converter voltage clamp oscillators and waveform generators Analog computer Capacitance multiplierSingle-unit recording (4,086 words) [view diff] case mismatch in snippet view article find links to article
Electrophysiology of the Neuron American College of Neuropsychopharmacology: Electrophysiology Neural Recordings Scholarpedia- Voltage Clamp BrainGateRetinal waves (2,743 words) [view diff] exact match in snippet view article find links to article
use showed that some correlated firing still remained where coupled voltage clamp recording showed significant reduction in correlated firing. The remainingNegative resistance (15,491 words) [view diff] no match in snippet view article find links to article
of neurons display regions of negative slope conductances (RNSC) in voltage-clamp experiments. The negative resistance here is implied were one to considerList of University of California, Berkeley faculty (15,213 words) [view diff] exact match in snippet view article find links to article
Kenneth S. Cole – Regents Professor, father of biophysics, invented the voltage clamp procedure Richard Dawkins – Visiting Assistant Professor of ZoologyList of 7400-series integrated circuits (1,789 words) [view diff] exact match in snippet view article find links to article
12-bit 1-of-3 FET multiplexer/demultiplexer 56 CBT 74x16222 22-bit voltage clamp 48 TVC 74x16232 synchronous 16-bit 1-of-2 FET multiplexer/demultiplexerMagnesium transporter (12,027 words) [view diff] exact match in snippet view article find links to article
AtMRS2-11 for Mg2+ is lower than that of Alr1p. An electrophysiological (voltage clamp) analysis of the AtMRS2-11 protein in Xenopus oocytes also showed a