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searching for V600E 33 found (44 total)

alternate case: v600E

Ameloblastoma (2,687 words) [view diff] exact match in snippet view article find links to article

adjacent soft tissues is required. BRAF V600E gene and SMO gene mutations have been found in ameloblastomas. V600E mutation is also seen in other malignant
List of drugs granted breakthrough therapy designation (163 words) [view diff] exact match in snippet view article find links to article
Pharmaceuticals melanoma with BRAF V600E or V600K mutations Trametinib Novartis Pharmaceuticals melanoma with BRAF V600E or V600K mutations Dabrafenib Novartis
MEK inhibitor (719 words) [view diff] exact match in snippet view article find links to article
encorafenib for the treatment of patients with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma. Cobimetinib or XL518, approved by US
Sodium/iodide cotransporter (3,133 words) [view diff] exact match in snippet view article find links to article
contrast, growth factors such as IGF-1 and TGF-β (which is induced by the BRAF-V600E oncogene) suppress NIS gene expression, not letting NIS localize in the
Papillary thyroid cancer (3,945 words) [view diff] exact match in snippet view article find links to article
associated (P=0.0005) with BRAF V600E mutation. According to recent studies, papillary cancers carrying the common V600E mutation tend to have a more aggressive
C-Raf (8,674 words) [view diff] exact match in snippet view article find links to article
single amino acid: Val 600 into Glu, and this aberrant gene product (BRAF-V600E) can be visualized by immunohistochemistry for clinical molecular diagnostics
Brunangelo Falini (2,061 words) [view diff] exact match in snippet view article find links to article
cell leukemia (HCL). His discoveries of NPM1 mutations in AML and BRAF-V600E in HCL, identified new mechanisms of leukemogenesis and resulted into improvement
Cardiac glycoside (1,836 words) [view diff] exact match in snippet view article find links to article
et al. (September 2021). "Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy". Aging Cell. 20 (9): e13447
Cancer biomarker (4,969 words) [view diff] exact match in snippet view article find links to article
(chronic myeloid leukemia), BRCA1 / BRCA2 (breast/ovarian cancer), BRAF V600E (melanoma/colorectal cancer), CA-125 (ovarian cancer), CA19.9 (pancreatic
Melanoma (15,962 words) [view diff] exact match in snippet view article find links to article
approved dabrafenib as a single agent treatment for patients with BRAF V600E mutation-positive advanced melanoma. Some researchers believe that combination
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (2,752 words) [view diff] exact match in snippet view article find links to article
THADA gene fusions, and BRAF K601E mutations may be seen on occasion. BRAF V600E mutations and RET gene fusions that are commonly seen in classical type
Sorafenib (2,607 words) [view diff] exact match in snippet view article find links to article
(January 2009). "CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations". Oncogene. 28 (1): 85–94. doi:10.1038/onc.2008.362. PMC 2898184
Targeted therapy (2,197 words) [view diff] exact match in snippet view article find links to article
dabrafenib, LGX818) used to treat metastatic melanoma that harbors BRAF V600E mutation MEK inhibitors (trametinib, MEK162) are used in experiments, often
Cobimetinib (1,021 words) [view diff] exact match in snippet view article find links to article
vemurafenib for the treatment of advanced melanoma with BRAF mutation (either V600E or V600K) that cannot be removed by surgery or which has metastasized. In
Senolytic (1,986 words) [view diff] exact match in snippet view article find links to article
et al. (September 2021). "Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy". Aging Cell. 20 (9): e13447
Langerhans cell histiocytosis (4,066 words) [view diff] exact match in snippet view article find links to article
McClain, Kenneth L.; Allen, Carl E. (10 December 2011). "1372 Frequent BRAF V600E Mutations Are Identified in CD207+ Cells in LCH Lesions, but BRAF Status
Roche (5,246 words) [view diff] exact match in snippet view article find links to article
urticaria (CIU), and nasal polyps. Zelboraf (vemurafenib), for late-stage V600E BRAF mutation-positive melanoma. Zenapax (daclizumab), for the prevention
Matthias Preusser (583 words) [view diff] exact match in snippet view article find links to article
Birner, A. von Deimling, M. Preusser: Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases.
TBX3 (4,710 words) [view diff] exact match in snippet view article find links to article
Tran SL, Gowrishankar K, Shaw HM, et al. (May 2013). "Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin
Phosphoinositide-dependent kinase-1 (2,109 words) [view diff] exact match in snippet view article find links to article
pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma". Oncogene. 33 (34): 4330–9. doi:10.1038/onc.2013.383
U0126 (722 words) [view diff] exact match in snippet view article find links to article
with trametinib for pediatric patients with low-grade glioma with a BRAF V600E mutation". FDA. "Trametinib". Drug Bank. Retrieved 2023-10-24. Favata MF
Monoclonal B-cell lymphocytosis (4,199 words) [view diff] exact match in snippet view article find links to article
cells, similar to the monoclonal cells in Hairy cell leukemia, may have the V600E mutation in the BRAF gene. Patients with this lymphoma commonly have enlarged
Natalie Ahn (1,154 words) [view diff] exact match in snippet view article find links to article
half of melanoma cells, the B-Raf protein contains a missense mutation (V600E mutation), which is responsible for cell transformation, invasion, and metastasis
Antoni Ribas (professor) (1,194 words) [view diff] exact match in snippet view article
people with a type of melanoma that contains a potent gene mutation, BRAF V600E, survived longer without the cancer progressing when they received a combination
Embryonal fyn-associated substrate (4,846 words) [view diff] exact match in snippet view article find links to article
treatment in BRAF wild-type melanoma tumors comparing to ones with BRAF (V600E-vemurfenib resistant) mutation. Finally, in a 2013 study of castration-resistant
Diffuse leptomeningeal glioneuronal tumor (898 words) [view diff] exact match in snippet view article find links to article
occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation. J Neurooncol 128:293–302. https://doi.org/10.1007/s11060-016-2109-x
Sandro Santagata (1,492 words) [view diff] exact match in snippet view article find links to article
Ligon, Azra H.; Louis, David N.; Santagata, Sandro (2011-03-29). "BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic
Epigenetic clock (7,936 words) [view diff] exact match in snippet view article find links to article
accelerated DNAm age in breast cancer. Colorectal cancer samples with a BRAF (V600E) mutation or promoter hypermethylation of the mismatch repair gene MLH1
List of antineoplastic agents (534 words) [view diff] exact match in snippet view article find links to article
(uncommon/rare). Vemurafenib PO BRAF kinase inhibitor. BRAF kinase mutation V600E-positive Metastatic melanoma. Skin reactions, secondary malignancies (mostly
Zhimin Lu (1,876 words) [view diff] exact match in snippet view article find links to article
activation of growth factor receptors, expression of K-Ras G12V and B-Raf V600E, and hypoxia induce the mitochondrial translocation of PGK1, which phosphorylates
Yuri Nikiforov (scientist) (2,520 words) [view diff] exact match in snippet view article
Using Next-Generation Sequencing Identifies Concordant Occurrence of BRAF V600E Mutations. Chest. 2013, 143(6):1679-84. Dettmer M, Vogetseder A, Durso MB
MicroRNA sequencing (5,200 words) [view diff] exact match in snippet view article find links to article
IgVH status miR-15a, miR-195, miR-221, miR-155, miR-23b Melanoma with BRAF V600E miR-193a, miR-338, miR-565 Lymphoma Diffuse Large B Cell Lymphoma has-miR-128
RBM10 (5,530 words) [view diff] exact match in snippet view article find links to article
Hsu N, Bhasin M, Roti G, Joshi M, Van Hummelen P, et al. (October 2017). "V600E". Oncotarget. 8 (49): 84743–84760. doi:10.18632/oncotarget.21262. PMC 5689570