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searching for Therapeutic index 52 found (157 total)

alternate case: therapeutic index

Cyclazodone (294 words) [view diff] exact match in snippet view article find links to article

drugs such as pemoline and thozalinone. It displayed a favorable therapeutic index and margin of safety in comparison to Pemoline and other N-lower-alkyl-substituted
Ro4-1539 (211 words) [view diff] exact match in snippet view article find links to article
experiments. Although it has high potency, long duration, and good therapeutic index (1100 in animal studies), Ro4-1539 had no particular clinical advantages
Retrometabolic drug design (2,795 words) [view diff] exact match in snippet view article find links to article
are aimed at designing safe, locally active compounds with improved therapeutic index (ratio of benefit vs. side effect). The concept of retrometabolic
Arabinopyranosyl-N-methyl-N-nitrosourea (540 words) [view diff] exact match in snippet view article find links to article
(compared to other nitrosoureas available at that time) and a wider therapeutic index, which allows for its outpatient administration. It was first synthesized
Vanoxerine (1,431 words) [view diff] exact match in snippet view article find links to article
increasing dosages, vanoxerine has shown to have a highly favourable therapeutic index, showing no side effects at concentrations much higher than the therapeutic
Siltuximab (831 words) [view diff] exact match in snippet view article find links to article
Co-administration of siltuximab and CYP450 substrates with narrow therapeutic index such as warfarin, ciclosporin or theophylline should be closely monitored
Racemic mixture (1,802 words) [view diff] exact match in snippet view article find links to article
specific drug may be done for a better safety profile or an improved therapeutic index. This process is called chiral switching and the resulting enantiopure
Illudin (224 words) [view diff] case mismatch in snippet view article find links to article
"Structure-Activity Relationship of Illudins : Analogs with Improved Therapeutic Index". Journal of Organic Chemistry. 57 (25): 6876–6883. doi:10.1021/jo00051a037
Quark Pharmaceuticals (590 words) [view diff] exact match in snippet view article find links to article
The result showed a favorable safety profile for the drug with a therapeutic index in rats greater than 250. Quark Pharmaceutical signed a collaboration
Santonin (2,592 words) [view diff] case mismatch in snippet view article find links to article
formularies as late as the '50s; the Modern Drug Encyclopedia and Therapeutic Index of 1955 listed Lumbricide (produced by Massengill) and a generic santonin
Dibenzepin (763 words) [view diff] exact match in snippet view article find links to article
treatment of chronic neuropathic pain. As TCAs have a relatively narrow therapeutic index, the likelihood of overdose (both accidental and intentional) is fairly
Chlorambucil (1,153 words) [view diff] exact match in snippet view article find links to article
a nitrogen, leading to the nitrogen mustards. With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in the clinic in
Multifocal atrial tachycardia (1,211 words) [view diff] exact match in snippet view article find links to article
it can be caused by theophylline toxicity, a drug with a narrow therapeutic index commonly used to treat COPD. Theophylline can cause a number of different
Neosaxitoxin (5,199 words) [view diff] exact match in snippet view article find links to article
cardiac effects. And last but not least, some degree of improving in therapeutic index of NSTX can be observed when is mixed with bupivacaine and/or epinephrine
Potassium bromide (1,261 words) [view diff] exact match in snippet view article find links to article
and excretion of which strongly influences bromide's excretion. The therapeutic index (ratio of effectiveness to toxicity) for bromide is small. As with
Analeptic (1,619 words) [view diff] exact match in snippet view article find links to article
respiratory analeptic in newborn infants. Theophylline has a very narrow therapeutic index, so its dosages must be supervised by direct measurement of serum
Glucuronic acid (1,869 words) [view diff] exact match in snippet view article find links to article
doses of affected medications and, unless the drug has a very wide therapeutic index, will generally result in the acute failure of the pharmacotherapy
Itraconazole (2,306 words) [view diff] exact match in snippet view article find links to article
patients, often resulting in serum concentrations lower than the therapeutic index. It has therefore been conventionally advised that patients take itraconazole
Flecainide (2,532 words) [view diff] exact match in snippet view article find links to article
increases the capture thresholds of pacemakers. Due to the narrow therapeutic index of flecainide, physicians should be alert for signs of toxicity before
Levothyroxine (3,112 words) [view diff] case mismatch in snippet view article find links to article
National Library of Medicine. "Real-world Evidence from a Narrow Therapeutic Index Product (Levothyroxine) Reflects the Therapeutic Equivalence of Generic
Hydroxychloroquine (4,306 words) [view diff] exact match in snippet view article find links to article
conditions, diabetes, or psoriasis. Hydroxychloroquine has a narrow therapeutic index, meaning there is little difference between toxic and therapeutic
Α-Amanitin (2,433 words) [view diff] exact match in snippet view article find links to article
C, Pahl A, Anderl J (2015). Amanitin-based ADCs with an improved therapeutic index. Poster #633. AACR Annual Meeting. Anderl J, Faulstich H, Hechler
Selective glucocorticoid receptor modulator (2,490 words) [view diff] exact match in snippet view article find links to article
glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index" (PDF). Molecular and Cellular Endocrinology. 275 (1–2): 109–17. doi:10
Anxiotropic (265 words) [view diff] exact match in snippet view article find links to article
Benzodiazepines are generally preferred to barbiturates, as there is a wider therapeutic index, meaning there is a greater distance between therapeutic and toxic
Sleep deprivation (11,963 words) [view diff] exact match in snippet view article find links to article
the fact that they have a low therapeutic index, while melatonin agonists are shown to have a higher therapeutic index. National Geographic Magazine has
Basil Ellenbogen (218 words) [view diff] case mismatch in snippet view article find links to article
Liverpool University, where he studied medicine, graduating in 1941. A Therapeutic Index, by Clarence Montague Miller and Basil Kazen Ellenbogen (1955) He
Cyclophosphamide (4,019 words) [view diff] exact match in snippet view article find links to article
proved to be cytotoxic in vitro (footnote omitted), but to have a low therapeutic index in vivo. Cyclophosphamide and the related nitrogen mustard–derived
Treatment-resistant depression (2,723 words) [view diff] exact match in snippet view article find links to article
10 000), and higher selectivity, safety, and thus slightly broader therapeutic index. When depression is related or co-morbid to an inattention disorder
Comparison of psychoactive alcohols in alcoholic drinks (62 words) [view diff] exact match in snippet view article find links to article
intoxication by alcoholic drink (ABV x potency compared to EtOH / total ABV) Therapeutic index (Potency compared to EtOH/EtOH LD50:LD50 ratio) Potency compared to
Ciprofloxacin (7,047 words) [view diff] exact match in snippet view article find links to article
ciprofloxacin is cautioned in patients on theophylline due to its narrow therapeutic index. The authors of one review recommended that patients being treated
Omphalotus illudens (649 words) [view diff] case mismatch in snippet view article find links to article
"Structure-Activity Relationship of Illudins : Analogs with Improved Therapeutic Index". Journal of Organic Chemistry. 57 (25): 6876–6883. doi:10.1021/jo00051a037
Antibody-drug conjugate (3,808 words) [view diff] exact match in snippet view article find links to article
and novel conjugation techniques to further improve stability and therapeutic index, α emitting immunoconjugates, antibody-conjugated nanoparticles and
Estradiol pivalate (700 words) [view diff] case mismatch in snippet view article find links to article
B12 U.S.P. 125 mcg. Howard ME (1949). Modern Drug Encyclopedia and Therapeutic Index. Drug Publications. [...] Supply: ESTROTATE—Vials, multi dose 10 cc
Anthracycline (4,984 words) [view diff] exact match in snippet view article find links to article
S, Tulpule A, Levine AM, Oliveros S (August 2009). "Improving the therapeutic index of anthracycline chemotherapy: focus on liposomal doxorubicin (Myocet)"
Anticoagulant (8,635 words) [view diff] exact match in snippet view article find links to article
have fewer drug interactions, no known dietary interactions, wider therapeutic index, and have conventional dosing that does not require dose adjustments
CYP2C9 (4,701 words) [view diff] exact match in snippet view article find links to article
therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin, and other routinely prescribed drugs
Abiraterone acetate (3,907 words) [view diff] exact match in snippet view article find links to article
concurrently with substrates of any of these enzymes that have a narrow therapeutic index. Spironolactone generally exerts anti-androgenic effects, but experimental
Heparin (7,447 words) [view diff] exact match in snippet view article find links to article
facilitating a more subtle regulation of coagulation and an improved therapeutic index. It is a synthetic pentasaccharide, whose chemical structure is almost
BRAF (gene) (5,187 words) [view diff] exact match in snippet view article
HT, Zhang SY, et al. (December 2006). "Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885"
Laura Soucek (812 words) [view diff] exact match in snippet view article find links to article
She has demonstrated that inhibition of Myc can have a dramatic therapeutic index in mouse models of cancer, causing minimal side effects in normal
Targeted covalent inhibitors (2,041 words) [view diff] exact match in snippet view article find links to article
selective against wild-type EGFR that are expected to lead to a wider therapeutic index. The pan-ErbB inhibitor Neratinib was approved in the US in 2017 and
Nanotechnology in cosmetics (2,066 words) [view diff] exact match in snippet view article find links to article
membranes, which enhance transdermal drug delivery. Increase efficacy and therapeutic index of drug and stability via encapsulation Non-toxic, flexible, biocompatible
Estradiol (medication) (15,427 words) [view diff] case mismatch in snippet view article
) in 30 cc. Marion E. Howard (1949). Modern Drug Encyclopedia and Therapeutic Index. Drug Publications. p. 696. Archived from the original on 7 June 2020
Progesterone (medication) (18,388 words) [view diff] case mismatch in snippet view article
Upjohn Company. Gutman, Jacob (1958). Modern Drug Encyclopedia and Therapeutic Index. Yorke Medical Group. p. 299. Greenblatt RB, Rose FD (June 1962).
Estradiol pivalate/progesterone (422 words) [view diff] case mismatch in snippet view article find links to article
functional uterine [...] Howard ME (1949). Modern Drug Encyclopedia and Therapeutic Index. Drug Publications. [...] Supply: ESTROTATE—Vials, multi dose 10 cc
Synaffix (492 words) [view diff] case mismatch in snippet view article find links to article
5b00224. PMID 26061183. "Synaffix Achieves Significantly Improved Therapeutic Index Compared to Both FDA-Approved ADCs and Expands Its Scientific Advisory
List of sex-hormonal aqueous suspensions (1,485 words) [view diff] case mismatch in snippet view article find links to article
ISBN 9780683002928. Marion E. Howard (1949). Modern Drug Encyclopedia and Therapeutic Index. Drug Publications. p. 697. Vademecum International. J. Morgan Jones
Mona Weissmark (2,162 words) [view diff] exact match in snippet view article find links to article
Journal of Psychotherapy Practice and Research, 1 (1), 37-48. "A therapeutic index: measuring therapeutic actions in psychotherapy." Weissmark, M., &
Prostaglandin inhibitors (2,115 words) [view diff] exact match in snippet view article find links to article
(2015). "Inhaled corticosteroids: potency, dose equivalence and therapeutic index". British Journal of Clinical Pharmacology. 80 (3): 372–380. doi:10
Pharmacokinetics of estradiol (26,664 words) [view diff] case mismatch in snippet view article find links to article
ISBN 9780683002928. Marion E. Howard (1949). Modern Drug Encyclopedia and Therapeutic Index. Drug Publications. p. 697. Vademecum International. J. Morgan Jones
Pregnenolone (medication) (1,514 words) [view diff] case mismatch in snippet view article
ISBN 978-1-4757-2085-3. Jacob Gutman (1955). Modern Drug Encyclopedia and Therapeutic Index. Yorke Medical Group. pp. 382–. Henderson E, Weinberg M, Wright WA
Chiral drugs (3,829 words) [view diff] exact match in snippet view article find links to article
separation is exorbitant. Insignificant/low toxicity of the distomer, high therapeutic index, mutually beneficial, pharmacological activities of both the enantiomers