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Longer titles found: Synucleinopathy (view), Alpha-synuclein (view), Gamma-synuclein (view), Beta-synuclein (view)

searching for Synuclein 133 found (222 total)

alternate case: synuclein

4-Oxo-2-nonenal (77 words) [view diff] exact match in snippet view article find links to article

peroxidation product that can structurally alter proteins and induce α-synuclein oligomers. Näsström, Thomas; Fagerqvist, Therese; Barbu, Mikael; et al

Contursi Terme (981 words) [view diff] exact match in snippet view article find links to article

by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders

Protein phosphorylation (7,997 words) [view diff] exact match in snippet view article find links to article

phosphorylated α-Synuclein to unphosphorylated α-Synuclein within a patient could be a marker of the disease progression. Antibodies that target α-Synuclein at phosphorylated

Ubiquitin carboxy-terminal hydrolase L1 (2,637 words) [view diff] exact match in snippet view article find links to article

activity and may lead to the aforementioned increase in aggregation of α-synuclein. The S18Y polymorphism of UCH-L1 has been shown to be less-prone to dimerization

Molecular tweezers (1,925 words) [view diff] exact match in snippet view article find links to article

proteins involved in Alzheimer's disease – amyloid β-protein (Aβ) and tau; α-synuclein, which is thought to cause Parkinson's disease and other synucleinopathies

Gene therapy in Parkinson's disease (1,813 words) [view diff] exact match in snippet view article find links to article

(glial cell line-derived neurotrophic factor), the regulation of the α-synuclein and Parkin gene expression. Currently the main studies are using AAV2

Susan Lindquist (2,740 words) [view diff] exact match in snippet view article find links to article

(2013). "Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons". Science. 342 (6161): 979–83. Bibcode:2013Sci...342

Tauopathy (1,518 words) [view diff] exact match in snippet view article find links to article

overlapped with synucleinopathies, possibly due to interaction between the synuclein and tau proteins. The non-Alzheimer's tauopathies are sometimes grouped

Site-directed spin labeling (690 words) [view diff] exact match in snippet view article find links to article

and the structure of membrane bound Parkinson's disease protein alpha-synuclein. A 2012 study generated a high resolution structure of IAPP fibrils using

Dennis J. Selkoe (1,008 words) [view diff] exact match in snippet view article find links to article

Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice (with Silke Nuber PhD, Alice Y. Nam BS, Molly M. Rajsombath BS, Haley

RNF19A (711 words) [view diff] exact match in snippet view article find links to article

ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript

Minzasolmin (154 words) [view diff] exact match in snippet view article find links to article

developed for Parkinson's disease that is designed to prevent misfolding of α-synuclein. Schwarz, Thomas C.; Beier, Andreas; Ledolter, Karin; Gossenreiter, Thomas;

Mir-7 microRNA precursor (1,373 words) [view diff] exact match in snippet view article find links to article

PMID 20230785. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry

Hsp104 (806 words) [view diff] exact match in snippet view article find links to article

is a heat-shock protein. It is known to reverse toxicity of mutant α-synuclein, TDP-43, FUS, and TAF15 in yeast cells. Conserved in prokaryotes (ClpB)

Mir-153 microRNA precursor family (768 words) [view diff] exact match in snippet view article find links to article

PMID 20152932. Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of Biological Chemistry

Tamir Gonen (1,133 words) [view diff] exact match in snippet view article find links to article

first novel structure was determined by MicroED for the protein alpha-synuclein at 1.4Å resolution in collaboration with David Eisenberg and in 2016 microED

Ted M. Dawson (2,756 words) [view diff] exact match in snippet view article find links to article

prominent role in the pathogenesis of Parkinson's disease due to pathologic α-synuclein. They discovered the parkin substrate, PARIS, which plays a key pathogenic

Amyloid (6,514 words) [view diff] exact match in snippet view article find links to article

atomic structures of amyloid fibrils formed by amyloid β peptides, α-synuclein, tau, and the FUS protein, associated with various neurodegenerative diseases

SMURF1 (1,916 words) [view diff] exact match in snippet view article find links to article

accumulation of α-synuclein aggregates. Furthermore, the overexpression of SMURF1 in cultured cells led to increased levels of α-synuclein aggregates, while

Proprotein convertase subtilisin/kexin type 1 inhibitor (582 words) [view diff] exact match in snippet view article find links to article

its potent ability to block the aggregation of beta amyloid and alpha synuclein in vitro, and to block oligomer cytotoxicity in cells. Recent data show

Cardiolipin (3,849 words) [view diff] exact match in snippet view article find links to article

protein into mitochondrial matrix Anticoagulant function Modulates α-synuclein - malfunction of this process is thought to be a cause of Parkinson's

DJ-1 (1,752 words) [view diff] exact match in snippet view article find links to article

oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functioning as a redox-sensitive chaperone

Pars compacta (975 words) [view diff] exact match in snippet view article find links to article

K; Paik, SR; Kim, J; Chung, KC (2003). "Parkin Cleaves Intracellular -Synuclein Inclusions via the Activation of Calpain". Journal of Biological Chemistry

ATP13A2 (712 words) [view diff] exact match in snippet view article find links to article

caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation". Human Molecular Genetics. 23 (11): 2791–801. doi:10.1093/hmg/ddt572

I-cell (443 words) [view diff] exact match in snippet view article find links to article

magnification of the alpha synuclein intraneuronal inclusions aggregated to form Lewy bodies. Stains used: mouse monoclonal alpha-synuclein antibody; counterstained

Dimitri Krainc (1,152 words) [view diff] exact match in snippet view article find links to article

A. and Krainc, D. (2011) Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell, 146(1):37-52

Hsp70 (5,629 words) [view diff] exact match in snippet view article find links to article

neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that increasing

TPPP (962 words) [view diff] exact match in snippet view article find links to article

(Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem

Patrik Brundin (1,274 words) [view diff] exact match in snippet view article find links to article

alpha-synuclein aggregates between neurons and developed corresponding animal models. This work contributed to the recognition of alpha-synuclein as a

LRRK2 (1,924 words) [view diff] exact match in snippet view article find links to article

and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain". The Journal of Neuroscience. 32 (22): 7585–93

DNAJA2 (717 words) [view diff] exact match in snippet view article find links to article

genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci...302.1769W. doi:10.1126/science

Neuroepigenetics (3,866 words) [view diff] exact match in snippet view article find links to article

disease (PD). A hallmark of Parkinson's disease is the accumulation of α-Synuclein in the brain. Increased exposure to manganese leads to the downregulation

Ranjith Padinhateeri (758 words) [view diff] exact match in snippet view article find links to article

"Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation". Biochemistry. 57 (5): 791–804. doi:10.1021/acs

Early-onset parkinsonism-intellectual disability syndrome (365 words) [view diff] exact match in snippet view article find links to article

X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology". American Journal of Human Genetics. 95 (6): 729–735. doi:10

Astrocyte (9,253 words) [view diff] exact match in snippet view article find links to article

FABP proteins have recently been shown to interact with a protein called synuclein to cause mitochondrial damage. Possible roles in pathophysiology Astrocytes

Chaperone-mediated autophagy (3,623 words) [view diff] exact match in snippet view article find links to article

membrane of pathogenic proteins known to accumulate in these disorders (α-synuclein, UCHL1 in Parkinson’s disease and mutant Tau in tauopathies). These toxic

FKBP2 (838 words) [view diff] exact match in snippet view article find links to article

genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci...302.1769W. doi:10.1126/science

Parkinson's Foundation (3,070 words) [view diff] exact match in snippet view article find links to article

Parkinson's Foundation found evidence that Parkinson's requires the alpha-synuclein protein, a now well-known hallmark of the disease. In 2011, the Parkinson's

Naled (1,278 words) [view diff] exact match in snippet view article find links to article

chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes". Molecular Brain

Vesicular monoamine transporter (5,000 words) [view diff] exact match in snippet view article find links to article

attributable to certain diseases with suspected SNP-mutation origins. α-synuclein, a cytosolic protein found mainly in pre-synaptic nerve terminals, has

Conformational ensembles (837 words) [view diff] exact match in snippet view article find links to article

(December 2009). "Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements". Journal of

Ankyrin-1 (1,687 words) [view diff] exact match in snippet view article find links to article

Liscovitch, N; French, L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease"

Ion transporter (2,028 words) [view diff] exact match in snippet view article find links to article

Ali AA, Gamble-George J, Chirwa S, Khoshbouei H (December 2011). "α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates

Chromosome 5 (2,298 words) [view diff] exact match in snippet view article find links to article

neuron 1, telomeric SMN2: survival motor neuron 2, centromeric SNCAIP: synuclein, alpha interacting protein (synphilin) SPEF2: Sperm flagellar protein

Infantile neuroaxonal dystrophy (902 words) [view diff] exact match in snippet view article find links to article

Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain". Cell Metabolism. 28 (4): 605–618.e6. doi:10.1016/j.cmet.2018.05

Sigma-2 receptor (1,832 words) [view diff] exact match in snippet view article find links to article

stresses such as oxidative stress and the build-up of amyloid-β and α-synuclein oligomers. Studies support that sigma-2 modulators can rescue biological

Coproporphyrinogen III oxidase (2,080 words) [view diff] exact match in snippet view article find links to article

E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase". Journal of Molecular

GRK5 (1,986 words) [view diff] exact match in snippet view article find links to article

"Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". The Journal of Biological Chemistry. 275 (1): 390–7. doi:10.1074/jbc

DNAJC5 (1,881 words) [view diff] exact match in snippet view article find links to article

G, Fernández-Chacón R, Schlüter OM, Südhof TC (November 2005). "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration". Cell. 123 (3):

Valina L. Dawson (3,384 words) [view diff] exact match in snippet view article find links to article

determining neuronal viability. Their labs also discovered that pathologic α-synuclein spreads in the nervous system via engagement with the lymphocyte-activation

Protein misfolding cyclic amplification (1,121 words) [view diff] exact match in snippet view article find links to article

; Low, Phillip A.; Soto, Claudio (5 February 2020). "Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy". Nature. 578

Clinical neurochemistry (2,611 words) [view diff] exact match in snippet view article find links to article

rest and bradykinesia. In some rare forms, protein aggregation of alpha-synuclein and parkin can elicit symptoms of Parkinson's disease. For a variety of

Autophagy (9,050 words) [view diff] exact match in snippet view article find links to article

proteins that have been tagged with ubiquitin to get degraded. Mutations of synuclein alleles lead to lysosome pH increase and hydrolase inhibition. As a result

Breakthrough Prize in Life Sciences (351 words) [view diff] exact match in snippet view article find links to article

amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson's disease and Multiple System

MAP1B (1,060 words) [view diff] exact match in snippet view article find links to article

protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200

Mel B. Feany (446 words) [view diff] exact match in snippet view article find links to article

1146/annurev-pathol-011110-130242. PMID 21034221. Chen, Li; Feany, Mel B. (2005). "Α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila

YWHAE (1,633 words) [view diff] exact match in snippet view article find links to article

Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci

Vesicular monoamine transporter 2 (2,015 words) [view diff] exact match in snippet view article find links to article

(2008). "Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells". Cell. Mol. Neurobiol. 28 (1): 35–47

David C. Rubinsztein (1,252 words) [view diff] exact match in snippet view article find links to article

PMC 2635561. PMID 17486044. Winslow, A. R.; Rubinsztein, D. C. (2010). "α-Synuclein impairs macroautophagy: implications for Parkinson's disease". The Journal

FICD (2,276 words) [view diff] exact match in snippet view article find links to article

Montenegro, Paola; Cannon, Jason; Rochet, Jean-Christophe (2019-05-31). "Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications

RIT2 (734 words) [view diff] exact match in snippet view article find links to article

Liscovitch N, French L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease"

Dopamine receptor D3 (3,171 words) [view diff] exact match in snippet view article find links to article

some variants may be subject to nonsense-mediated decay (NMD). Alpha-synuclein (α-Syn) aggregation via Lewy bodies inclusion, a pathogenic signature

Neuroprotection (3,640 words) [view diff] exact match in snippet view article find links to article

S2CID 32651665. Li W, Lee MK (June 2005). "Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3

Florbetaben (18F) (1,589 words) [view diff] exact match in snippet view article

selective binding for β-amyloid over other proteins (e.g., tau and a-synuclein) has been demonstrated in vitro. Initial single-center studies demonstrated

Mounir Laroussi (1,151 words) [view diff] exact match in snippet view article find links to article

Agatha; Greene, Lesley; Laroussi, Mounir (2010-10-04). "Destruction of α-synuclein based amyloid fibrils by a low temperature plasma jet". Applied Physics

Ad Bax (944 words) [view diff] exact match in snippet view article find links to article

Levine RL; Bax A (February 2013). "Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates". J. Am

RPH3A (1,097 words) [view diff] exact match in snippet view article find links to article

PMID 12937130. Dalfó E, Barrachina M, Rosa JL, et al. (2004). "Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease". Neurobiol

Protein aggregation predictors (2,523 words) [view diff] exact match in snippet view article find links to article

"A simple algorithm locates β-strands in the amyloid fibril core of α-synuclein, Aβ, and tau using the amino acid sequence alone". Protein Science. 16

Crocin (1,568 words) [view diff] exact match in snippet view article find links to article

Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats' Striatum". Journal of Molecular Neuroscience. 72 (5): 983–993

Eva Braak (396 words) [view diff] exact match in snippet view article find links to article

Braak, E.; Sandmann-Keil, D.; Rüb, U.; Gai WP, R.A.I (2001). "Alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain

Torsin A (910 words) [view diff] exact match in snippet view article find links to article

Ozelius LJ, et al. (2001). "A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study". Am. J

Cytochrome c oxidase subunit III (2,390 words) [view diff] exact match in snippet view article find links to article

E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase". Journal of Molecular

C7orf31 (631 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

Michael J. Zigmond (404 words) [view diff] exact match in snippet view article find links to article

Jen J.; Guo, Fengli; Zigmond, Michael J. (2002-04-15). "A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis". Journal of Neuroscience.

Flow-induced dispersion analysis (614 words) [view diff] exact match in snippet view article find links to article

Langkilde, Annette Eva (2020). "Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion". The FASEB Journal. 34 (6): 7462–7482

Amyloid plaques (3,891 words) [view diff] exact match in snippet view article find links to article

(September 2002). "Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's

Amyloidosis (5,435 words) [view diff] exact match in snippet view article find links to article

precursor, wild type Aβ protein precursor, variant CNS CNS L L A H AαSyn α-Synuclein CNS L A ATau Tau CNS L A APrP Prion protein, wild type Prion protein variants

2,4-dienoyl-CoA reductase 1 (536 words) [view diff] exact match in snippet view article find links to article

Toda T (2008). "Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89–94. doi:10

MAPK8IP1 (1,323 words) [view diff] exact match in snippet view article find links to article

PMID 11726277. Hashimoto M, Hsu LJ, Rockenstein E, et al. (2002). "alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal

Ultrafine particle (2,639 words) [view diff] exact match in snippet view article find links to article

Ultrafine Particulate Deposition, and Accumulation of Amyloid Β-42 and Α-Synuclein in Children and Young Adults". Toxicologic Pathology. 36 (2): 289–310

Bcl-2-associated death promoter (1,988 words) [view diff] exact match in snippet view article find links to article

Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci

C11orf52 (647 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

VDAC1 (4,077 words) [view diff] exact match in snippet view article find links to article

Kelly L, He Y, Waliczek T, Kordower JH (September 2014). "Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental

Inclusion body myositis (3,618 words) [view diff] exact match in snippet view article find links to article

amyloid-β (Aβ), tau, ubiquitinated proteins, apolipoprotein E, and β-synuclein in skeletal muscle. ... active immunization markedly reduces intracellular

Protein tag (2,523 words) [view diff] exact match in snippet view article find links to article

Christopher M. (September 2010). "Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody" (PDF). Journal of Molecular Biology

Rotenone (3,298 words) [view diff] exact match in snippet view article find links to article

Wu J, Li J, Xu L, Lv L, Yin Y, Hu X (2018-05-21). "Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's

Batten disease (3,388 words) [view diff] exact match in snippet view article find links to article

model of juvenile Batten disease". Experimental Neurology. The Role of α-synuclein in the Pathogenesis of Parkinson's Disease / Gene Therapy for Parkinson's

TFEB (2,233 words) [view diff] exact match in snippet view article find links to article

2013). "TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity". Proc Natl Acad Sci USA. 110 (19): 1817–26. Bibcode:2013PNAS

Gregor Wenning (1,067 words) [view diff] exact match in snippet view article find links to article

bestowed with the Bishop Golser Award for his characterization of pathogenic synuclein prions in MSA. In 2019 Dr. Wenning was appointed president of the scientific

C11orf53 (473 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–34100. doi:10.1074/jbc

Advanced glycation end-product (3,734 words) [view diff] exact match in snippet view article find links to article

"Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation"

Mathias Jucker (1,302 words) [view diff] exact match in snippet view article find links to article

been expanded to include several other proteins, including tau and α-synuclein, which similarly misfold and aggregate in a class of diseases known as

Ana Maria Cuervo (1,114 words) [view diff] exact match in snippet view article find links to article

PT; Sulzer, D (27 August 2004). "Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy". Science. 305 (5688): 1292–5. Bibcode:2004Sci

C1orf131 (1,278 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". J. Biol. Chem. (39th ed.). 286 (39): 34088–34100. doi:10.1074/jbc.m111

C6orf201 (882 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

Daniella Goldfarb (554 words) [view diff] exact match in snippet view article find links to article

Bekei; et al. (25 January 2016). "Structural disorder of monomeric α-synuclein persists in mammalian cells". Nature. 530 (7588): 45–50. doi:10.1038/NATURE16531

Natural killer cell (9,172 words) [view diff] exact match in snippet view article find links to article

disease, levels of Natural killer cells are elevated as they degrade alpha-synuclein aggregates, destroy senescent neurons, and attenuate the neuroinflammation

Dena Dubal (1,112 words) [view diff] exact match in snippet view article find links to article

Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice. eScholarship, University of California. OCLC 1122541777

Marc Baldus (1,223 words) [view diff] exact match in snippet view article find links to article

"Molecular-level secondary structure, polymorphism, and dynamics of full-length -synuclein fibrils studied by solid-state NMR". Proceedings of the National Academy

Copy number variation (5,557 words) [view diff] exact match in snippet view article find links to article

Johnson J, Singleton A, Hague S, Kachergus J, et al. (October 2003). "alpha-Synuclein locus triplication causes Parkinson's disease". Science. 302 (5646): 841

Sirtuin 2 (3,748 words) [view diff] exact match in snippet view article find links to article

Hyman BT, Kazantsev AG (Jul 2007). "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. 317 (5837):

Plasma gelsolin (9,114 words) [view diff] exact match in snippet view article find links to article

peptides and proteins: Actin (see: Relationships with actin),Apo-H,Aβ,α-Synuclein,Integrin,Tcp-1,Fibronectin,Syntaxin-4,Tropomyosin,fatty acids and phospholipids

Royal Medal (440 words) [view diff] exact match in snippet view article find links to article

Biology "for identifying and characterising assembled tau protein and alpha-synuclein and showing that they form the inclusions of Alzheimer’s and Parkinson’s

Ujjwal Maulik (1,908 words) [view diff] exact match in snippet view article find links to article

; Dey, A.; Maulik, U. (11 August 2021). "Studying the Effect of Alpha-Synuclein and Parkinson's Disease Linked Mutants on Inter Pathway Connectivity's"

Tardigrade specific proteins (1,649 words) [view diff] exact match in snippet view article find links to article

(October 2003). "A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders". Journal

KIAA0825 (1,741 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

Microfluidic diffusional sizing (877 words) [view diff] exact match in snippet view article find links to article

MDS in sizing protein-nanobody complexes, monitoring the formation of α-synuclein amyloid fibrils. and in observing protein assembly into oligomers MDS

Mitophagy (4,036 words) [view diff] exact match in snippet view article find links to article

CR; Cardoso, SM (2011). "Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011: 693761. doi:10.4061/2011/693761

Pituitary pars intermedia dysfunction (2,770 words) [view diff] exact match in snippet view article find links to article

MT, Miller L, Cribb AE (February 2005). "Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary

ENDOG (2,404 words) [view diff] exact match in snippet view article find links to article

Meisinger C, Sigrist SJ, Madeo F (Nov 2013). "Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease". The EMBO Journal. 32 (23): 3041–54

Gintonin (3,194 words) [view diff] exact match in snippet view article find links to article

MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway". Mol Neurobiol. 56 (1): 39–55. doi:10.1007/s12035-018-1020-1

DMAC1 (1,577 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". J Biol Chem. 286 (39): 34088–34100. doi:10.1074/jbc.M111.243907. PMC 3190826

CLPB (2,095 words) [view diff] exact match in snippet view article find links to article

10-fold. Indeed, PARL-activated Skd3 is capable of disassembling alpha-synuclein fibrils in vitro. Even though the bacterial orthologue, ClpB, contributes

Super-resolution microscopy (9,961 words) [view diff] exact match in snippet view article find links to article

(2017). "Morphological analysis of oligomeric vs. fibrillar forms of α-synuclein aggregates with super-resolution BALM imaging". Chemical Physics Letters

Ubiquitin C (4,261 words) [view diff] exact match in snippet view article find links to article

Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E (March 2008). "alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in

CFAP299 (1,099 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

Sylvain Lesné (3,138 words) [view diff] exact match in snippet view article find links to article

Kuskowski M, Schneider JA, Bennett DA, Lesné SE (July 2012). "Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology". J Neurosci

William Langston (2,132 words) [view diff] exact match in snippet view article find links to article

Langston JW (Feb 2004). "Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications". Ann Neurol. 55 (2): 174–9. doi:10.1002/ana.10846

Collin M. Stultz (1,352 words) [view diff] exact match in snippet view article find links to article

I., Pochapsky, T., & Stultz, C. M. (2013). The Dynamic Structure of α-Synuclein Multimers. Journal of the American Chemical Society, 135(10), 3865–3872

Biochemical cascade (11,411 words) [view diff] exact match in snippet view article find links to article

challenged with toxic insults or genetically modified. The central role of a-synuclein has generated many models aiming to elucidate its contribution to the

Rudolph E. Tanzi (4,331 words) [view diff] exact match in snippet view article find links to article

targeting metal-induced aggregation of beta-amyloid in AD and of alpha-synuclein and Lewy bodies in Parkinson's disease. In 2000, Tanzi and Steven Wagner

Michelle Gray (2,336 words) [view diff] exact match in snippet view article find links to article

Huiping & Fineberg, Naomi & Gray, Michelle & Yacoubian, Talene. (2013). α-Synuclein Overexpression Represses 14-3-3θ Transcription. Journal of molecular neuroscience :

Translatomics (2,953 words) [view diff] exact match in snippet view article find links to article

Michele (2016-05-03). "Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor". Proceedings

BEND2 (protein) (1,796 words) [view diff] exact match in snippet view article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

Ccdc60 (1,286 words) [view diff] exact match in snippet view article find links to article

tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of Biological Chemistry. 286 (39): 34088–100. doi:10.1074/jbc

Nancy Bonini (2,940 words) [view diff] exact match in snippet view article find links to article

Trojanowski JQ, Lee VM, Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295(5556):865-8

Ryszard Przewłocki (1,609 words) [view diff] exact match in snippet view article find links to article

Thomas EA, Hilbush BS, Sutcliffe JG, PRZEWŁOCKI R.: Regulation of α-synuclein gene expression in limbic and motor brain regions of morphine-treated

Alzheimer's Disease Neuroimaging Initiative (4,886 words) [view diff] exact match in snippet view article find links to article

Ju-Hee (2016-05-01). "Cerebrospinal Fluid Amyloid β1-42, Tau, and Alpha-Synuclein Predict the Heterogeneous Progression of Cognitive Dysfunction in Parkinson's

Neuronal lineage marker (3,768 words) [view diff] exact match in snippet view article find links to article

synGAP; Synphilin-1; Syntaxin 1; Syntaxin 2; Syntaxin 3; Syntaxin 4; Synuclein alpha; VAMP-2; Vesicular Acetylcholine Transporter/VAChT; Vesicular GABA

CSNK1D (14,719 words) [view diff] exact match in snippet view article find links to article

plays a regulatory role in Parkinson's disease (PD) by phosphorylating α-synuclein. Familial advanced sleep phase syndrome (FASPS) is another neurological

Malú G. Tansey (2,796 words) [view diff] exact match in snippet view article find links to article

Laura M.; Houser, Madelyn C.; Tansey, Malú G. (11 September 2018). "α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson's Disease Pathogenesis"

List of women neuroscientists (8,913 words) [view diff] exact match in snippet view article find links to article

from 1980s), neuroscientist noted for identifying the protein alpha-synuclein as the major component of Lewy bodies Tara Spires-Jones (born 1976), neuroscientists

David F. Clayton (1,835 words) [view diff] exact match in snippet view article find links to article

circuit for song production learning, one of which encodes the alpha-synuclein protein, a key player in Parkinson's and other neurodegenerative diseases