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searching for Seizure threshold 54 found (83 total)

Barbiturate dependence (557 words) [view diff] exact match in snippet view article find links to article

low potency phenothiazines e.g. chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects; if used extreme caution is required

Laudanosine (328 words) [view diff] exact match in snippet view article find links to article

metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold

SZT2 (387 words) [view diff] exact match in snippet view article find links to article

Seizure threshold 2 homolog is a protein that in humans is encoded by the SZT2 gene. The protein encoded by this gene is expressed in the brain, predominantly

Aconitine (3,643 words) [view diff] exact match in snippet view article find links to article

value Cat LD50 Intravenous 0.080 Behavioral: convulsions or effect on seizure threshold Cat LDLo Subcutaneous 0.100 Details of toxic effects not reported

Dextromethorphan/bupropion (2,133 words) [view diff] exact match in snippet view article find links to article

Auvelity may decrease the seizure threshold. Anybody with bulimia or anorexia. As these disorders can lower the seizure threshold, and it may make food avoidance

Kindling (sedative–hypnotic withdrawal) (1,746 words) [view diff] exact match in snippet view article

which govern anxiety and seizure threshold; thus kindling may result in increased severity of anxiety and a lowered seizure threshold during repeated withdrawal

Catamenial epilepsy (2,273 words) [view diff] exact match in snippet view article find links to article

neurons, leading to a decreased seizure threshold. In female adult rat experimental trials, the limbic seizure threshold fluctuates inversely to estradiol

Ethoxzolamide (175 words) [view diff] exact match in snippet view article find links to article

It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular

LY-2365109 (153 words) [view diff] exact match in snippet view article find links to article

extracellular levels of glycine. LY-2365109 has been shown to increase the seizure threshold in mice, meaning that this drug has potential as an anticonvulsant

Primidone (6,952 words) [view diff] exact match in snippet view article find links to article

the barbiturate class; however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. The drug’s

U-69,593 (562 words) [view diff] exact match in snippet view article find links to article

"Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266". Pharmacology & Toxicology

Methohexital (388 words) [view diff] exact match in snippet view article find links to article

Unlike many other barbiturates, methohexital actually lowers the seizure threshold, a property that makes it particularly useful when anesthesia is provided

Toxidrome (538 words) [view diff] exact match in snippet view article find links to article

anticonvulsant, some such as GHB and methaqualone instead lower the seizure threshold, so can cause paradoxical seizures in overdose. The symptoms of a

Absence seizure (3,533 words) [view diff] exact match in snippet view article find links to article

weakening of electrical signal which leads to a reduction in the seizure threshold. Intermittent photic stimulation may precipitate or facilitate absence

Borage seed oil (821 words) [view diff] exact match in snippet view article find links to article

and after surgery. Because borage oil can theoretically lower the seizure threshold due to its GLA content, it could therefore trigger a seizure in users

Convulsant (1,116 words) [view diff] exact match in snippet view article find links to article

S2CID 28716793. Calabrese EJ (2008). "Modulation of the epileptic seizure threshold: implications of biphasic dose responses". Critical Reviews in Toxicology

Metabolic alkalosis (1,290 words) [view diff] exact match in snippet view article find links to article

nervous system Reduction in blood flow Confusion Obtundation Reduced seizure threshold Neuromuscular Increased excitability Tetany Cardiovascular Reduced

Reflex seizure (2,193 words) [view diff] exact match in snippet view article find links to article

occur due to changes in the brain that result in the lowering of the seizure threshold in a particular individual making that person vulnerable to recurring

Anion exchange protein 3 (1,288 words) [view diff] exact match in snippet view article find links to article

targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold". Molecular and Cellular Biology. 26 (1): 182–191. doi:10.1128/MCB

Tapentadol (5,399 words) [view diff] exact match in snippet view article find links to article

compared with oxycodone). Tapentadol has been demonstrated to reduce the seizure threshold in patients. Tapentadol should be used cautiously in patients with

Gene therapy for epilepsy (2,918 words) [view diff] exact match in snippet view article find links to article

inserted vectors 8 weeks prior to kindling, showing an increase in seizure threshold. In order to evaluate the effects after epileptogenesis was present

Dosulepin (2,102 words) [view diff] exact match in snippet view article find links to article

to a year. Contraindications include: Epilepsy as it can lower the seizure threshold TCAs should not be used concomitantly or within 14 days of treatment

Methylazoxymethanol acetate (637 words) [view diff] exact match in snippet view article find links to article

found impaired cognitive function in GD15 MAM rats, and a reduced seizure threshold. At the cellular level, dysplastic hippocampal neurons in the MAM

Biperiden (1,420 words) [view diff] no match in snippet view article find links to article

architecture may be altered (REM sleep depression). Biperiden may lower the seizure-threshold. Some instances of dementia have been noted to correlate with chronic

Venlafaxine (6,132 words) [view diff] exact match in snippet view article find links to article

wort. Venlafaxine may lower the seizure threshold, and coadministration with other drugs that lower the seizure threshold such as bupropion and tramadol

Chromosome 1 (3,301 words) [view diff] exact match in snippet view article find links to article

protein 1 STIL (1p33) SYCP1: Synaptonemal complex protein 1 SZT2: Seizure threshold 2 homolog TACSTD2: tumor-associated calcium signal transducer 2 TAL1

Trihexyphenidyl (2,347 words) [view diff] no match in snippet view article find links to article

be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold. Peripheral side effects: dry mouth, impaired sweating, abdominal

KCNQ2 developmental and epileptic encephalopathy (539 words) [view diff] exact match in snippet view article find links to article

of Kv7.2 channels in vivo. Both these mouse models show a reduced seizure threshold. "KCNQ2 Encephalopathy". NORD (National Organization for Rare Disorders)

Clomipramine (11,765 words) [view diff] no match in snippet view article find links to article

anti-convulsant medication, thereby theoretically increasing the seizure-threshold in patients (which clomipramine decreases to an extent which precludes

Neonatal seizure (4,791 words) [view diff] exact match in snippet view article find links to article

to excessive excitation and reduced inhibition, which lowers their seizure threshold when compared with that of adults. This has been proved in animal

Trifluoperazine (1,100 words) [view diff] exact match in snippet view article find links to article

fatal neuroleptic malignant syndrome. Trifluoperazine can lower the seizure threshold. The antimuscarinic action of trifluoperazine can cause excessive

Benzodiazepine (17,215 words) [view diff] exact match in snippet view article find links to article

low potency phenothiazines, e.g., chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects; if used extreme caution is required

Hydroxychloroquine (4,802 words) [view diff] exact match in snippet view article find links to article

used concurrently. Mefloquine and other drugs known to lower the seizure threshold (co-administration with other antimalarials known to lower the convulsion

Epileptogenesis (3,699 words) [view diff] exact match in snippet view article find links to article

triggering inflammatory cascades that modulate synaptic function and lower seizure threshold. If unresolved, neuroinflammation promotes neuronal hyperexcitability

Alcohol withdrawal syndrome (4,237 words) [view diff] exact match in snippet view article find links to article

Antipsychotics may potentially worsen alcohol withdrawal as they lower the seizure threshold. Clozapine, olanzapine, or low-potency phenothiazines (such as chlorpromazine)

Ciprofloxacin (6,597 words) [view diff] exact match in snippet view article find links to article

other fluoroquinolones, is known to trigger seizures or lower the seizure threshold, and may cause other central nervous system adverse effects. Headache

Amifampridine (3,494 words) [view diff] exact match in snippet view article find links to article

especially torsade de pointes; and combination with drugs that lower the seizure threshold increases the risk of seizures. Interactions via the liver's cytochrome

Lofepramine (2,593 words) [view diff] exact match in snippet view article find links to article

reduce the anticonvulsant effect of antiepileptics by lowering the seizure threshold. Antihistamines. Possible increase of antimuscarinic (potentially

Development of the cerebral cortex (2,929 words) [view diff] exact match in snippet view article find links to article

knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice". J Clin Invest. 121 (4): 1596–1607. doi:10.1172/JCI44909

Basic helix-loop-helix ARNT-like protein 1 (5,803 words) [view diff] exact match in snippet view article find links to article

Furthermore, BMAL1 has been shown to influence excitability and seizure threshold. In addition, BMAL1 gene expression, along with that of other core

Maprotiline (5,053 words) [view diff] exact match in snippet view article find links to article

and kidney function Epilepsy and other conditions that lower the seizure threshold (active brain tumors, alcohol withdrawal, other medications) Serious

Haloperidol (5,448 words) [view diff] exact match in snippet view article find links to article

noted (anticholinergic and cardiovascular side effects, lowering of seizure threshold) Several lines of evidence suggest that haloperidol exhibits neurotoxicity

Karen Gale (785 words) [view diff] exact match in snippet view article find links to article

bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models". Neurobiology of Disease. 91:

Causes of seizures (3,839 words) [view diff] case mismatch in snippet view article find links to article

Foundation Stafstrom, Carl E. (July 2003). "Hyperglycemia Lowers Seizure Threshold". Epilepsy Currents. 3 (4): 148–149. doi:10.1046/j.1535-7597.2003

Neuromuscular-blocking drug (6,872 words) [view diff] exact match in snippet view article find links to article

release of histamine Harmful metabolite called laudanosine (lowering seizure threshold); greater accumulation in individuals with renal failure Cisatracurium

Ketotifen (7,512 words) [view diff] exact match in snippet view article find links to article

or concomitant use of other drugs that cause sedation or lower the seizure threshold. In children, ketotifen overdose may lead to toxic encephalopathy

Separation anxiety in dogs (4,647 words) [view diff] exact match in snippet view article find links to article

process similar to one experienced by humans. For example, their seizure threshold is lowered and anxiety relapse can occur after stopping benzodiazepine

Laura S. Boylan (840 words) [view diff] exact match in snippet view article find links to article

Spicknall, K.; Lisanby, S. H.; Sackeim, H. A. (2000–03). "Determinants of seizure threshold in ECT: benzodiazepine use, anesthetic dosage, and other factors"

Anti-VGKC-complex encephalitis (1,570 words) [view diff] exact match in snippet view article find links to article

mice cause lethal epilepsy and the heterozygous mice have a lowered seizure threshold. Mutations of CNTNAP2 (the gene encoding CASPR2) have been reported

Fitness to dive (10,000 words) [view diff] exact match in snippet view article find links to article

decision-making. bupropion, trazodone and venlafaxine may lower the seizure threshold. Venlafaxine may occasionally cause fainting, excitability and difficulty

Epilepsy in children (7,560 words) [view diff] exact match in snippet view article find links to article

stimulants, antidepressants, and antipsychotics have shown to lower seizure threshold and can increase neuro stability. Three-fourths of children that take

History of electroconvulsive therapy in the United Kingdom (3,959 words) [view diff] exact match in snippet view article find links to article

pre-treatment physical examination, avoidance of currents greatly above seizure threshold and the use of machines with a choice of waveforms. The question of

Brendan P. Lucey (1,565 words) [view diff] exact match in snippet view article find links to article

study, which indicated decreased seizure likelihood but increased seizure threshold with sleep deprivation in a different set of GEFS+ flies, indicated

List of phenyltropanes (5,846 words) [view diff] exact match in snippet view article find links to article

pethidine, N-demethyl compounds are more toxic and have a decreased seizure threshold. ɑThe N-demethylated variant of (i.e. compound code-name after dash)