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searching for Remyelination 56 found (80 total)

alternate case: remyelination

Demyelinating disease (2,701 words) [view diff] exact match in snippet view article find links to article

in regions of active remyelination and may play an important role in generating a local environment conducive to remyelination. N-cadherin agonists have
Cholesterol crystal (494 words) [view diff] exact match in snippet view article find links to article
macrophages is believed to be associated with multiple sclerosis, and this remyelination failure is particularly impaired in the elderly. Dowling RH (2000).
Véronique Miron (514 words) [view diff] exact match in snippet view article find links to article
therapies on oligodendroglial lineage cells, myelin maintenance, and remyelination". She then carried out her postdoctoral studies at the Centre for Regeneration
Neuroregeneration (3,575 words) [view diff] exact match in snippet view article find links to article
scars rapidly form, and the glia actually produce factors that inhibit remyelination and axon repair; for instance, NOGO and NI-35. The axons themselves
Cerebroside (723 words) [view diff] exact match in snippet view article find links to article
Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. The sugar moiety is linked glycosidically to the C-1 hydroxyl group
Paola Leone (279 words) [view diff] exact match in snippet view article find links to article
Cure to study the potential of subpopulations of stem cells to promote remyelination and phenotypic rescue in animal models of white matter disease, including
David Lucchino (966 words) [view diff] exact match in snippet view article find links to article
under the ticker symbol FREQ. Today, Frequency's lead program is for remyelination in multiple sclerosis (MS) with a focus on developing a therapeutic
Cyclin-dependent kinase 5 (5,354 words) [view diff] exact match in snippet view article find links to article
Multiple sclerosis (MS): is one of the diseases, in which a failure of remyelination can provoke lasting axonal damage and an irreversible loss of function
Glycolipid (1,589 words) [view diff] exact match in snippet view article find links to article
Morell P (May 2001). "Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain". Journal of Neurochemistry
Michael Fehlings (1,184 words) [view diff] exact match in snippet view article find links to article
neural stem cells in repairing/regenerating injured spinal cords through remyelination of axons. This finding has been key in leading clinical translational
Myelin regulatory factor (720 words) [view diff] exact match in snippet view article find links to article
in the myelin sheath. Further, the activity of MYRF increases during remyelination, suggesting it has a critical role in this process. Animals with repressed
Gliotransmitter (2,128 words) [view diff] exact match in snippet view article find links to article
in sleep, cognition, synaptic function and plasticity, and promote remyelination and regeneration of injured nervous tissue. Other functions include
Stinger (medicine) (1,878 words) [view diff] exact match in snippet view article
function involves demyelination. Axonal integrity is preserved, and remyelination occurs within days or weeks. Grade II is categorized by axonotmesis
Cerebrolysin (1,049 words) [view diff] exact match in snippet view article find links to article
Granatov EV, Shakirzianova SR (2016). "[Effect of cerebrolysin on remyelination processes in multiple sclerosis patients in stage of relapse regression]"
Ursolic acid (1,664 words) [view diff] exact match in snippet view article find links to article
treatment of multiple sclerosis through both immunomodulation and direct remyelination". Proceedings of the National Academy of Sciences. 117 (16): 9082–9093
Myelitis (2,486 words) [view diff] exact match in snippet view article find links to article
inflammation, to modulate the immune system, and to enhance regeneration and remyelination of axons. Neural stem cells (NSC) have the potential to integrate with
GPR17 (1,805 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor 17". Fumagalli M, Lecca D, Abbracchio MP (2016). "CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles
Neurodegenerative disease (6,972 words) [view diff] exact match in snippet view article find links to article
PMC 6915812. PMID 31885862. Irvine, K. A.; Blakemore, W. F. (2008). "Remyelination protects axons from demyelination-associated axon degeneration". Brain
Cobalt compounds (1,850 words) [view diff] exact match in snippet view article find links to article
Almog, Ronit; Galboiz, Yanina (2005). "Vitamin B12, demyelination, remyelination and repair in multiple sclerosis". Journal of the Neurological Sciences
Paclitaxel (6,391 words) [view diff] exact match in snippet view article find links to article
increase the number of microtubules in the cell. Paclitaxel induces remyelination in a demyelinating mouse in vivo and inhibits hPAD2 in vitro though
Montelukast (2,218 words) [view diff] exact match in snippet view article find links to article
pathway of leukotrienes.[citation needed] Montelukast may affect nerve remyelination in combination with Pexidartinib and this may cause clinical benefits
CXCL1 (1,706 words) [view diff] exact match in snippet view article find links to article
Santambrogio L, Lira SA, Raine CS (January 2009). "Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1"
Glial fibrillary acidic protein (3,260 words) [view diff] exact match in snippet view article find links to article
S2CID 209498996. Bunge MB, Bunge RP, Ris H (May 1961). "Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord". The Journal of
Glia (3,767 words) [view diff] exact match in snippet view article find links to article
(2020-07-09). "Macroglial diversity: white and grey areas and relevance to remyelination". Cellular and Molecular Life Sciences. 78 (1): 143–171. doi:10
Pathology of multiple sclerosis (17,161 words) [view diff] exact match in snippet view article find links to article
astrogliosis, oligodendrocyte injury, neurodegeneration, axonal loss and remyelination. MS lesions evolve differently during early versus chronic disease phases
Segesterone acetate (1,940 words) [view diff] exact match in snippet view article find links to article
et al. (October 2011). "Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors". Endocrinology. 152 (10): 3820–3831
Biotin (5,118 words) [view diff] exact match in snippet view article find links to article
demyelinating autoimmune disease. The hypothesis is that biotin may promote remyelination of the myelin sheath of nerve cells, slowing or even reversing neurodegeneration
Biogen (3,704 words) [view diff] exact match in snippet view article find links to article
hurdle". Fierce Biotech. Retrieved 2013-04-08. "Lingo: a promising remyelination target in MS". Multiple Sclerosis Research. Retrieved 2014-06-16. "Isis
Eicosanoid receptor (2,893 words) [view diff] exact match in snippet view article find links to article
PMID 27863043. S2CID 10935349. Fumagalli M, Lecca D, Abbracchio MP (2016). "CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles
Krembil Research Institute (1,839 words) [view diff] exact match in snippet view article find links to article
"Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury". Journal
Phosphatidylinositol-4-phosphate 5-kinase (1,235 words) [view diff] exact match in snippet view article find links to article
is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS". Neuron. 85 (6): 1227–43. doi:10.1016/j.neuron.2015.02.024
Prolactin (5,820 words) [view diff] exact match in snippet view article find links to article
VW, Weiss S (February 2007). "White matter plasticity and enhanced remyelination in the maternal CNS". The Journal of Neuroscience. 27 (8): 1812–23.
Nerve injury (4,113 words) [view diff] exact match in snippet view article find links to article
Wenlong (2010). "Short-term low-frequency electrical stimulation enhanced remyelination of injured peripheral nerves by inducing the promyelination effect of
Coronavirus (10,579 words) [view diff] exact match in snippet view article find links to article
Whitman L, Lane TE (July 2010). "Cell replacement therapies to promote remyelination in a viral model of demyelination". Journal of Neuroimmunology. 224
Pathophysiology of multiple sclerosis (9,020 words) [view diff] exact match in snippet view article find links to article
Möbius W, Simons M (2018). "Defective cholesterol clearance limits remyelination in the aged central nervous system". Science. 359 (6376): 684–688. Bibcode:2018Sci
Murine coronavirus (4,189 words) [view diff] exact match in snippet view article find links to article
Whitman L, Lane TE (July 2010). "Cell replacement therapies to promote remyelination in a viral model of demyelination". Journal of Neuroimmunology. 224
Interleukin 6 (7,425 words) [view diff] exact match in snippet view article find links to article
neurons and, hence, may be important in nerve regeneration through remyelination. Interleukin-6 has been shown to interact with interleukin-6 receptor
Glutamate receptor (6,872 words) [view diff] exact match in snippet view article find links to article
influx. The experiments showed improved oligodendrocyte survival, and remyelination increased. Furthermore, CNS inflammation, apoptosis, and axonal damage
Κ-opioid receptor (7,664 words) [view diff] exact match in snippet view article find links to article
VW, Weiss S (February 2007). "White matter plasticity and enhanced remyelination in the maternal CNS". The Journal of Neuroscience. 27 (8): 1812–23.
Lesional demyelinations of the central nervous system (4,833 words) [view diff] exact match in snippet view article find links to article
plaques or lesions usually reported in MS. A repair process, called remyelination, takes place in early phases of the disease, but the oligodendrocytes
Stem-cell therapy (9,576 words) [view diff] exact match in snippet view article find links to article
Positive migration of the injected cells to the site of lesion, increased remyelination detected by Myelin Basic Proteins, positive differentiation into Olig2
Reticulon 4 (1,924 words) [view diff] exact match in snippet view article find links to article
Vinters HV, et al. (December 2016). "Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery
Multiple sclerosis drug pipeline (9,409 words) [view diff] exact match in snippet view article find links to article
PMC 6100297. PMID 30150982. Neumann B, et al. (2019). "Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells". Cell Stem Cell. 25 (4): 473–485
Transforming growth factor beta (8,659 words) [view diff] exact match in snippet view article find links to article
growth. Hence, the decreased TGF-β levels during MS may also prevent remyelination of neurons. Higher concentrations of TGF-β are found in the blood and
Immune system contribution to regeneration (1,363 words) [view diff] exact match in snippet view article find links to article
CNS. Microglia and macrophages together help in the oligodendrocyte remyelination. Intestinal injury of the epithelia activates macrophages that secrete
Hes3 signaling axis (3,339 words) [view diff] exact match in snippet view article find links to article
expression in the adult mouse brain is regulated during demyelination and remyelination". Brain Research. 1642: 124–30. doi:10.1016/j.brainres.2016.03.014.
Sammy Lee (scientist) (2,427 words) [view diff] exact match in snippet view article
reproduction. He was attached to the Jessen-Mirsky laboratory and was studying remyelination. Lee had ethical committee approval in Brasil for creating artificial
Nerve compression syndrome (6,598 words) [view diff] exact match in snippet view article find links to article
inflammation, distal axon degeneration, extensive fibrosis, new axon growth, remyelination, and thickening of the perineurium and endothelium. Axonal degeneration
Katerina Akassoglou (1,923 words) [view diff] exact match in snippet view article find links to article
Strickland, Sidney (2002-03-14). "Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation". Neuron. 33 (6): 861–875
Catherine Lubetzki (764 words) [view diff] exact match in snippet view article find links to article
Wikidata Q37183765. Kirby, Tony (2020-08-01). "Catherine Lubetzki—expert on remyelination in multiple sclerosis". The Lancet Neurology. 19 (8): 648. doi:10
Nano-scaffold (3,850 words) [view diff] exact match in snippet view article find links to article
stem cells and Schwann cells and for promoting axon restoration and remyelination. Olfactory ensheathing cells, stem cells, and other neural progenitor
Patrizia Casaccia (2,600 words) [view diff] exact match in snippet view article find links to article
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency (News and Views and Highlights in Nature Neuroscience Reviews)
Multiple sclerosis biomarkers (7,797 words) [view diff] exact match in snippet view article find links to article
loss dominates in the T1 hypointense core and that the effects of de/remyelination may be better detected in the "T2-rim", where there is relative preservation
Nicole Schaeren-Wiemers (2,147 words) [view diff] exact match in snippet view article find links to article
Jaggi S, Enz LS, Jacob C, Schaeren-Wiemers N.: Theophylline Induces Remyelination and Functional Recovery in a Mouse Model of Peripheral Neuropathy. In:
Etrinabdione (492 words) [view diff] exact match in snippet view article find links to article
C, et al. (September 2020). "Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis". Neurobiology of Disease. 143:
Myelinoid (4,903 words) [view diff] exact match in snippet view article find links to article
(2021). "Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System". Frontiers in Cellular Neuroscience.