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Longer titles found: QT interval variability (view)

searching for QT interval 94 found (216 total)

Probucol (684 words) [view diff] exact match in snippet view article find links to article

patients with a previous history of heart disease. It may also cause QT interval prolongation. Probucol was originally developed as an industrial antioxidant

Artemether/lumefantrine (1,164 words) [view diff] exact match in snippet view article find links to article

appetite, and headache. Serious side effects include prolongation of the QT interval. While not well studied, it appears to be safe for use in pregnancy.

HERG (2,337 words) [view diff] exact match in snippet view article find links to article

containing channels are blocked by amiodarone, and it does prolong the QT interval, but its multiple other antiarrhythmic effects prevent this from causing

List of antineoplastic agents (708 words) [view diff] exact match in snippet view article find links to article

leukaemia Diarrhoea, thrombocytopenia, neutropenia, hepatotoxicity, QT interval prolongation, kidney failure, pleural effusion, pericarditis (uncommon/rare)

Fabio Badilini (1,401 words) [view diff] exact match in snippet view article find links to article

the Holter Bin Method for assessing the effect of heart rate upon the QT interval that has been used in New Drug Applications to the FDA. In 1998, he led

Cardiotoxicity (1,444 words) [view diff] exact match in snippet view article find links to article

Proteasome Inhibitors Antipsychotics such as thioridazine which can prolong QT interval Antibiotics such as Erythromycin and levofloxacin due to QT prolongation

List of withdrawn drugs (1,903 words) [view diff] exact match in snippet view article find links to article

(Raxar) 1999 Withdrawn Germany, UK, US others Cardiac repolarization; QT interval prolongation. Hydromorphone (Palladone, extended release version) 2005

Postoperative nausea and vomiting (1,670 words) [view diff] exact match in snippet view article find links to article

dose at the end of surgery. Adverse effects include prolongation of the QT interval on electrocardiogram (EKG). Medications include ondansetron, granisetron

CALM3 (1,606 words) [view diff] exact match in snippet view article find links to article

functioning in 2 directions and long QT syndrome which is associated with the QT interval in the electrocardiogram that is significantly longer than normal. In

Azimilide (953 words) [view diff] exact match in snippet view article find links to article

chlorophenylfuranyl compound, which slows repolarization of the heart and prolongs the QT interval of the electrocardiogram. Prolongation of atrial or ventricular repolarization

Ketanserin (2,221 words) [view diff] exact match in snippet view article find links to article

ketanserin include dizziness, tiredness, edema, dry mouth, weight gain, and QT interval prolongation. Ketanserin acts as a selective antagonist of the serotonin

Pimozide (931 words) [view diff] exact match in snippet view article find links to article

individuals with either acquired, congenital or a family history of QT interval prolongation. Its use is advised against in individuals with people with

Sertindole (1,227 words) [view diff] exact match in snippet view article find links to article

the 2nd lowest effect size for causing EPSE) Venous thromboembolism QT interval prolongation (probably common; in a recent meta-analysis of the efficacy

Dextromethorphan/quinidine (605 words) [view diff] exact match in snippet view article find links to article

drugs that both prolong the QT interval and are metabolized by CYP2D6 (e.g., thioridazine, pimozide); effects on QT interval may be increased Concomitant

Droperidol (912 words) [view diff] exact match in snippet view article find links to article

resulting from peripheral alpha adrenoceptor blockade, prolongation of QT interval which can lead to torsades de pointes, and extrapyramidal side effects

Norfloxacin (4,599 words) [view diff] exact match in snippet view article find links to article

been completed. FQs prolong the QT interval by blocking voltage-gated potassium channels. Prolongation of the QT interval can lead to torsades de pointes

Antiarrhythmic agent (1,997 words) [view diff] exact match in snippet view article find links to article

myocyte repolarization. Class III agents have the potential to prolong the QT interval of the EKG, and may be proarrhythmic (more associated with development

Haloperidol (5,471 words) [view diff] exact match in snippet view article find links to article

dyskinesia which may be permanent. Neuroleptic malignant syndrome and QT interval prolongation may occur, the latter particularly with IV administration

Fred Lange-Nielsen (154 words) [view diff] exact match in snippet view article find links to article

Congenital deaf-mutism, functional heart disease with prolongation of the QT interval and sudden death. American Heart Journal, 1957; 54: 59 - 68. Willems

Bedaquiline (2,309 words) [view diff] exact match in snippet view article find links to article

warning for increased risk of death and arrhythmias, as it may prolong the QT interval by blocking the hERG channel. Everyone on bedaquiline should have monitoring

Proarrhythmia (267 words) [view diff] exact match in snippet view article find links to article

Increased age. Females. Dose independent, occurring at normal levels. Follow QT interval, keep ms. May be provoked by increased heart rate. Exercise stress tests

XEN-D0101 (470 words) [view diff] exact match in snippet view article find links to article

ventricular contraction, as determined by assessing the QT interval on an echocardiogram. The QT interval represents ventricular depolarization and repolarization

The Cambridge Diet (1,161 words) [view diff] exact match in snippet view article find links to article

diet. Observations in 17 patients and the role of the prolonged QT interval". Circulation. 60 (6): 1401–12. doi:10.1161/01.cir.60.6.1401. PMID 498466

Hibernation (5,349 words) [view diff] exact match in snippet view article find links to article

the reduced relaxation (QT) interval of small hibernators was the same for the three bear species. They also found the QT interval changed for both typical

Myxedema coma (945 words) [view diff] exact match in snippet view article find links to article

Polymorphic ventricular tachycardia (torsades de pointes) Prolonged QT interval Respiratory Hypoxia Hypercapnia Hyperventilation Myxedema of the larynx

Alpha blocker (3,197 words) [view diff] exact match in snippet view article find links to article

orthostatic hypotension, or heart palpitations via alterations of the QT interval. Alpha blockers that may have these side effects include yohimbine, phenoxybenzamine

Flupentixol/melitracen (722 words) [view diff] exact match in snippet view article find links to article

initial phase of the treatment. Tachycardia, palpitations, prolonged QT interval, hypotension. Thrombocytopenia, neutropenia, leukopenia, agranulocytosis

List of adverse effects of nilotinib (463 words) [view diff] exact match in snippet view article find links to article

tachycardia, atrial fibrillation, ventricular extrasystoles, bradycardia) QT interval prolonged Palpitations Cough Dyspnoea Abdominal distension Abdominal

Bone morphogenetic protein 10 (529 words) [view diff] exact match in snippet view article find links to article

Aulchenko YS, et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN

Arsenic poisoning (9,472 words) [view diff] exact match in snippet view article find links to article

nervous system can also be affected, causing disruption to heart rhythms (QT interval prolongation or tachycardia), heart failure, confusion, seizures, brain

Hypoparathyroidism (1,629 words) [view diff] exact match in snippet view article find links to article

irregularities in the normal heart beat (specifically prolongation of the QT interval), as well as spasm of the upper part of the airways or the smaller airways

Protein-sparing modified fast (diet) (999 words) [view diff] exact match in snippet view article

diet. Observations in 17 patients and the role of the prolonged QT interval". Circulation. 60 (6): 1401–1412. doi:10.1161/01.CIR.60.6.1401. ISSN 0009-7322

Arsenic poisoning (9,472 words) [view diff] exact match in snippet view article find links to article

nervous system can also be affected, causing disruption to heart rhythms (QT interval prolongation or tachycardia), heart failure, confusion, seizures, brain

Arthur J. Moss (907 words) [view diff] case mismatch in snippet view article find links to article

Cervicothoracic Sympathetic Ganglionectomy for the Treatment of Long QT Interval Syndrome". New England Journal of Medicine. 285 (16): 903–904. doi:10

Vandetanib (1,191 words) [view diff] exact match in snippet view article find links to article

OATP1B3 transporter but not for OATP1B1. Other drugs that prolong the QT interval can possibly add to this side effect of vandetanib. As the drug is partly

Indapamide (1,032 words) [view diff] exact match in snippet view article find links to article

the combination of indapamide with lithium and drugs causing prolonged QT interval (on EKG) or wave-burst arrhythmia (i.e.: astemizole, bepridil, IV erythromycin

Ribociclib (1,814 words) [view diff] exact match in snippet view article find links to article

vs. 22%), as was alopecia (33% vs. 16%). The drug also increases the QT interval and liver enzymes (alanine transaminase, aspartate transaminase). The

Prenylamine (416 words) [view diff] exact match in snippet view article find links to article

2005. It was withdrawn from market worldwide in 1988 because it caused QT interval prolongation and torsades de pointes, greatly increasing the risk of

Hypocalcemia (1,867 words) [view diff] exact match in snippet view article find links to article

QT prolongation, or intermittent prolongation of the QTc (corrected QT interval) on the ECG (electrocardiogram) is noted. The implications of intermittent

Antitarget (777 words) [view diff] exact match in snippet view article find links to article

Montanaro, N. (2002). "Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview". Drug Safety. 25 (4): 263–286

Syndromes affecting the heart (113 words) [view diff] exact match in snippet view article find links to article

This condition affects the QT interval (in blue)

Celivarone (1,224 words) [view diff] case mismatch in snippet view article find links to article

Abildskov, JA (August 1991). "The Sympathetic Imbalance Hypothesis of QT Interval Prolongation". Journal of Cardiovascular Electrophysiology. 2 (4): 355–359

Dolasetron (661 words) [view diff] exact match in snippet view article find links to article

associated with its use. There is a potential for prolonging of the QT interval to occur as well. There have been no significant drug interactions reported

Ajmaline (1,301 words) [view diff] exact match in snippet view article find links to article

longer. Slower depolarization or repolarization results in a lengthened QT interval (the refractory period), and therefore makes it take more time for the

Safety pharmacology (1,337 words) [view diff] exact match in snippet view article find links to article

evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. [2]. ICH S6(R1): Preclinical

Amoxapine (2,742 words) [view diff] exact match in snippet view article find links to article

cardiovascular disorders (potential of cardiotoxic adverse effects such as QT interval prolongation) Uncorrected narrow angle glaucoma Acute recovery post-myocardial

Procainamide (2,095 words) [view diff] exact match in snippet view article find links to article

which induces failure of the pacemaker and death. Thus, it prolongs QT interval of action potential and increases the risk of torsade de pointes. Procainamide

Peter R. Kowey (1,010 words) [view diff] exact match in snippet view article find links to article

PR (2003). "Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization". Circulation. 107

Pazopanib (1,322 words) [view diff] exact match in snippet view article find links to article

include: Hypertension, including hypertensive crises have been reported. QT interval prolongation and torsades de pointes have been reported. Thrombotic microangiopathy

Very-low-calorie diet (2,317 words) [view diff] exact match in snippet view article find links to article

diet. Observations in 17 patients and the role of the prolonged QT interval". Circulation. 60 (6): 1401–12. doi:10.1161/01.cir.60.6.1401. PMID 498466

Vicriviroc (2,046 words) [view diff] exact match in snippet view article find links to article

caused a modest but dose-dependent prolongation of the corrected cardiac QT interval (QTc), leading to examination of alternative compounds whose antiviral

H3 receptor antagonist (2,154 words) [view diff] exact match in snippet view article find links to article

headache and anxiety. Pitolisant can also potentially cause a prolonged QT interval so caution is advised in cardiac patients. Keeping doses as low as possible

Sean P. Pinney (1,183 words) [view diff] exact match in snippet view article find links to article

Franz, MR; Woosley, Raymond L.; Ph (1995). "Terfenadine increases the QT interval in isolated guinea pig heart". J Cardiovasc Pharmacol. 25 (1): 30–34

Magnesium sulfate (3,069 words) [view diff] exact match in snippet view article find links to article

consideration of intravenous magnesium sulfate when secondary to a long QT interval. Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH (2005)

Sean P. Pinney (1,183 words) [view diff] exact match in snippet view article find links to article

Franz, MR; Woosley, Raymond L.; Ph (1995). "Terfenadine increases the QT interval in isolated guinea pig heart". J Cardiovasc Pharmacol. 25 (1): 30–34

Prucalopride (1,928 words) [view diff] exact match in snippet view article find links to article

these drugs. Clinical trials evaluating the effect of prucalopride on QT interval and related adverse events have not demonstrated significant differences

Scleroderma (3,293 words) [view diff] exact match in snippet view article find links to article

uncommonly hepatotoxicity, heart dysfunction/failure, myocardial infarction, QT interval prolongation, renal failure and hypersensitivity. Imatinib As above PO

Outline of cardiology (7,309 words) [view diff] exact match in snippet view article find links to article

of the QT interval — drug-induced QT prolongation — and an EKG may be warranted before starting the medication to ensure a normal QT interval, but this

KCNE3 (3,185 words) [view diff] exact match in snippet view article find links to article

expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval". The Journal of Clinical Investigation. 109 (8): 1083–90. doi:10.1172/JCI15062

Myocardial bridge (3,118 words) [view diff] exact match in snippet view article find links to article

Effect of Surgical Unroofing of a Myocardial Bridge on Exercise Induced QT interval Dispersion and Anginal Symptoms in Patients with Angina in the Absence

Hydrofluoric acid burn (961 words) [view diff] exact match in snippet view article find links to article

electrocardiogram (ECG). ECG changes may include QRS widening and a prolonged QT interval. Initial treatment of exposure involves removing contaminated clothing

Treatment of bipolar disorder (6,498 words) [view diff] exact match in snippet view article find links to article

respiratory tract infection, fatigue and generalised pains Prolonged QT interval, sudden cardiac death, syncope, diabetic ketoacidosis, hypothermia, pancreatitis

Magnesium deficiency (4,538 words) [view diff] exact match in snippet view article find links to article

electrocardiogram (ECG) change may show a tachycardia with a prolonged QT interval. Other changes may include prolonged PR interval, ST segment depression

Cariprazine (2,634 words) [view diff] exact match in snippet view article find links to article

levels, and unlike many other antipsychotics, does not increase the QT interval on the electrocardiogram (ECG). In short term clinical trials, extrapyramidal

KCNE2 (3,525 words) [view diff] exact match in snippet view article find links to article

genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study". Annals of Noninvasive

Trimethoprim/sulfamethoxazole (4,070 words) [view diff] exact match in snippet view article find links to article

(increased risk of ventricular arrhythmias) and dofetilide (increased risk of QT interval prolongation) Antibacterials like dapsone (increases plasma levels of

Melperone (1,291 words) [view diff] exact match in snippet view article find links to article

virtually nil). It is also purported to produce sedative effects and QT interval prolongation. It is also known to produce less extrapyramidal side effects

Hyperkalemia (4,877 words) [view diff] exact match in snippet view article find links to article

hyperkalemia are seen in the following progression: peaked T wave, shortened QT interval, lengthened PR interval, increased QRS duration, and eventually absence

Citalopram (4,603 words) [view diff] exact match in snippet view article find links to article

In August 2011, the FDA announced, "Citalopram causes dose-dependent QT interval prolongation. Citalopram should no longer be prescribed at doses greater

Raymond L. Woosley (1,234 words) [view diff] exact match in snippet view article find links to article

label. He is an authority on drugs, like methadone, that prolong the QT interval on the electrocardiogram and cause a particular potentially lethal cardiac

Toremifene (3,523 words) [view diff] exact match in snippet view article find links to article

elevation of liver enzymes have been reported. The drug prolongs the QT interval and hence has a risk of potentially fatal dysrhythmias. The risk of dysrhythmias

Digoxin (4,845 words) [view diff] exact match in snippet view article find links to article

increased PR interval (due to decreased AV conduction) and a shortened QT interval. Also, the T wave may be inverted and accompanied by ST depression. It

Milk-alkali syndrome (2,927 words) [view diff] exact match in snippet view article find links to article

following findings related to hypercalcemia could appear on an ECG: Short QT interval: most commonly seen as short OoT or OaT changes. Prolongation of PR and

Medical uses of magnesium sulfate (2,153 words) [view diff] exact match in snippet view article find links to article

consideration of intravenous magnesium sulfate when secondary to a long QT interval. Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, et al. (July

Paliperidone (2,054 words) [view diff] exact match in snippet view article find links to article

tachycardia (increased heart rate), high blood pressure, prolonged QT interval (an alteration of the electrical activity of the heart), upper respiratory

Buprenorphine/naloxone (3,519 words) [view diff] exact match in snippet view article find links to article

lower level of opioid tolerance, and those at high risk of prolonged QT interval. It is also helpful to use the medication in combination with psychosocial

Albert Hofman (epidemiologist) (1,209 words) [view diff] exact match in snippet view article

23;360(17):1718-28. Newton-Cheh C, et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet. 2009 Apr;41(4):399-406. Dehghan

N-alpha-acetyltransferase 10 (5,355 words) [view diff] exact match in snippet view article find links to article

carinatum, pulmonary artery stenosis, atrial septal defect, prolonged QT interval. The boy was reported as having small hands/feet, high arched palate

Phenothiazine (1,789 words) [view diff] exact match in snippet view article find links to article

on the central nervous system and cardiovascular system (particularly QT interval prolongation). The term "phenothiazines" describes the largest of the

Mianserin (3,063 words) [view diff] exact match in snippet view article find links to article

produce sedation, coma, hypotension or hypertension, tachycardia, and QT interval prolongation. Mianserin may enhance the sedative effects of drugs such

Clomipramine (11,697 words) [view diff] exact match in snippet view article find links to article

Purpura Conduction disorder (e.g. widening of QRS complex, prolonged QT interval, PR/PQ interval changes, bundle-branch block, torsade de pointes, particularly

Molecular autopsy (1,912 words) [view diff] exact match in snippet view article find links to article

the lethal disorders like long QT syndrome (LQTS). This is a prolonged QT interval in the heart’s natural rhythm. This is can leave no trace for an autopsy

Atomoxetine (6,170 words) [view diff] exact match in snippet view article find links to article

atomoxetine not be used with other medications that may prolong the QT interval, concomitantly with CYP2D6 inhibitors, and caution to be used in poor

Analgesic (5,859 words) [view diff] exact match in snippet view article find links to article

faeces. Opioid addiction; chronic pain. As per other opioids, plus QT interval prolongation. Piritramide Comes in free or tartrate salt forms. Mu opioid

Kathleen Folbigg (2,951 words) [view diff] exact match in snippet view article find links to article

of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval. It can cause fast, chaotic heartbeats, and can be life-threatening.

Amitriptyline (8,729 words) [view diff] exact match in snippet view article find links to article

antidepressants with greater risks of hepatic toxicity. Amitriptyline prolongs the QT interval. This prolongation is relatively small at therapeutic doses but becomes

List of diets (9,495 words) [view diff] exact match in snippet view article find links to article

diet. Observations in 17 patients and the role of the prolonged QT interval". Circulation. 60 (6): 1401–12. doi:10.1161/01.cir.60.6.1401. PMID 498466

Chronic kidney disease (8,948 words) [view diff] exact match in snippet view article find links to article

and a severe electrolyte imbalance: hyperkalemia (7.4 mmol/L) with hypocalcemia (1.6 mmol/L). The T-waves are peaked and the QT interval is prolonged.

Primidone (6,948 words) [view diff] exact match in snippet view article find links to article

Primidone has other cardiovascular effects in beyond shortening the QT interval. Both phenobarbital and it are associated with elevated serum levels

Selective serotonin reuptake inhibitor (15,104 words) [view diff] exact match in snippet view article find links to article

original on 2020-10-10. Retrieved 2019-12-16. Citalopram and escitalopram: QT interval prolongation – new maximum daily dose restrictions (including in elderly

Opioid use disorder (14,334 words) [view diff] exact match in snippet view article find links to article

Campbell A, Killip T, Kotz M, Krantz MJ, Kreek MJ, et al. (October 2011). "QT interval screening in methadone maintenance treatment: report of a SAMHSA expert

Sonlicromanol (2,476 words) [view diff] exact match in snippet view article find links to article

as multiple doses of 400 mg twice daily, QTcF (Fridericia's corrected QT interval) prolongation was observed. Post-hoc studies showed that this QTcF prolongation

Pharmacological cardiotoxicity (3,565 words) [view diff] case mismatch in snippet view article find links to article

(July 2013). "Development and Validation of a Risk Score to Predict QT Interval Prolongation in Hospitalized Patients". Circulation: Cardiovascular Quality

Bioinstrumentation (8,411 words) [view diff] exact match in snippet view article find links to article

arrhythmias in the heart and prolonged wave intervals, including the prolonged QT interval (which is a risk factor for ventricular arrhythmias) and both of these