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Longer titles found: Protein aggregation predictors (view)

searching for Protein aggregation 119 found (165 total)

Familial amyloid neuropathy (505 words) [view diff] exact match in snippet view article find links to article

autonomic nervous system and/or other nerves are compromised by protein aggregation and/or amyloid fibril formation. The aggregation of one precursor

Ataxin 7 (500 words) [view diff] exact match in snippet view article find links to article

Polyglutamine (polyQ) expansion at the N-terminus of ataxin-7 causes protein aggregation, leading to the symptoms of ataxia with visual loss. Research suggest

Fluorometer (1,409 words) [view diff] exact match in snippet view article find links to article

are dyes used for histology staining and biophysical studies of protein aggregation. For example, thioflavin T is used in the RT-QuIC technique to detect

CRYAB (1,442 words) [view diff] exact match in snippet view article find links to article

molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture

Hydrophobic mismatch (1,888 words) [view diff] exact match in snippet view article find links to article

mismatch-induced protein aggregation has been obtained. Also some experimental evidence that a hydrophobic mismatch can lead to protein aggregation in fluid bilayer

Lanosterol (760 words) [view diff] exact match in snippet view article find links to article

J.; Hou, R.; Wang, S.; Yan, Y. (2016). "Lanosterol reversal of protein aggregation in cataract". Acta Ophthalmologica. 94. doi:10.1111/j.1755-3768.2016

Heat shock response (2,435 words) [view diff] exact match in snippet view article find links to article

diseases. Heat shock proteins induced by the HSR can help prevent protein aggregation that is associated with common neurodegenerative diseases such as

Thioflavin (991 words) [view diff] exact match in snippet view article find links to article

Both are used for histology staining and biophysical studies of protein aggregation. In particular, these dyes have been used since 1989 to investigate

Neuroprotection (3,640 words) [view diff] exact match in snippet view article find links to article

dysfunction, excitotoxicity, inflammatory changes, iron accumulation, and protein aggregation. Of these mechanisms, neuroprotective treatments often target oxidative

TauRx Therapeutics (791 words) [view diff] exact match in snippet view article find links to article

who is currently the company's Executive Chairman. The company's protein aggregation inhibitors target the underlying pathology of dementia, with the

Co-chaperone (749 words) [view diff] exact match in snippet view article find links to article

important for preserving folding and assembly, therefore preventing protein aggregation. Detection of mutations in these proteins have been associated with

CDC48 N-terminal domain (220 words) [view diff] exact match in snippet view article find links to article

substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. It is composed

Benjamin Wolozin (1,579 words) [view diff] exact match in snippet view article find links to article

emphasize the role of protein aggregation in neurodegenerative disease as well as metabolic consequences of stress linked to protein aggregation or cellular damage

Regina Murphy (585 words) [view diff] exact match in snippet view article find links to article

Medical and Biological Engineering for "pioneering discoveries on protein aggregation in neurodegenerative disease." Murphy earned her Bachelor of Science

Physalaemin (546 words) [view diff] case mismatch in snippet view article find links to article

Formation by Tachykinin Neuropeptides and Its Relevance to Amyloid β-Protein Aggregation and Toxicity". Cell Biochemistry and Biophysics. 64 (1): 29–44. doi:10

Breakthrough Prize in Life Sciences (351 words) [view diff] exact match in snippet view article find links to article

molecular chaperones in mediating protein folding and preventing protein aggregation." Max Planck Institute of Biochemistry Arthur L. Horwich (b. 1951)

Molecular tweezers (1,925 words) [view diff] exact match in snippet view article find links to article

they may be developed as drugs against diseases caused by abnormal protein aggregation, all of which currently have no cure. They were also shown to destroy

John Scott Medal (451 words) [view diff] exact match in snippet view article find links to article

scans Jenny Pickworth Glusker crystallography 2010 Christian J. Lambertsen underwater diving equipment William A. Eaton protein aggregation and folding

Hsp27 (3,341 words) [view diff] exact match in snippet view article find links to article

In vitro it acts as an ATP-independent chaperone by inhibiting protein aggregation and by stabilizing partially denatured proteins, which ensures refolding

Devarajan (Dave) Thirumalai (680 words) [view diff] exact match in snippet view article

known for his contributions to the theories of protein/RNA folding, protein aggregation, glasses (the Random First Order Transition – RFOT theory), and biological

Tuomas Knowles (481 words) [view diff] exact match in snippet view article find links to article

behavior in health and disease. Knowles is known for his work on protein aggregation and for describing the kinetics of this process and the underlying

Guanidinium chloride (661 words) [view diff] exact match in snippet view article find links to article

hydrochloride inhibits the generation of prion "seeds" but not prion protein aggregation in yeast. Mol Cell Biol 22 (15):5593-5605. Eaglestone SS, Ruddock

DNAJB6 (1,270 words) [view diff] exact match in snippet view article find links to article

limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. GRCh38: Ensembl release 89: ENSG00000105993

Kosmotropic (641 words) [view diff] exact match in snippet view article find links to article

protein from an aqueous solution. Kosmotropes are used to induce protein aggregation in pharmaceutical preparation and at various stages of protein extraction

Hypochlorous acid (5,422 words) [view diff] exact match in snippet view article find links to article

of HClO's bactericidal role revealed it to be a potent inducer of protein aggregation. Hsp33, a chaperone known to be activated by oxidative heat stress

Halophile (2,705 words) [view diff] exact match in snippet view article find links to article

organisms expend energy to exclude salt from their cytoplasm to avoid protein aggregation ('salting out'). To survive the high salinities, halophiles employ

Viroplasm (1,652 words) [view diff] exact match in snippet view article find links to article

S2CID 26616991. Kopito RR (December 2000). "Aggresomes, inclusion bodies and protein aggregation". Trends in Cell Biology. 10 (12): 524–30. doi:10.1016/s0962-8924(00)01852-3

Pathophysiology (2,712 words) [view diff] exact match in snippet view article find links to article

major mechanisms for neuronal death in Parkinson's Disease include protein aggregation in Lewy bodies, disruption of autophagy, changes in cell metabolism

Richard I. Morimoto (4,165 words) [view diff] case mismatch in snippet view article find links to article

that Independent Nucleation Events Determines the Progression of Protein Aggregation in C. elegans. Proc. Natl. Acad. Sci. U.S.A. 118(11): https://doi

Synovial fluid (2,103 words) [view diff] exact match in snippet view article find links to article

PMID 15961430. < Oates, Katherine (2006). "Rheopexy of synovial fluid and protein aggregation". Journal of the Royal Society Interface. 3 (6): 167–74. doi:10.1098/rsif

PABPN1 (1,214 words) [view diff] exact match in snippet view article find links to article

"Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death". Hum. Mol. Genet. 10 (21): 2341–51

Clinical neurochemistry (2,611 words) [view diff] exact match in snippet view article find links to article

include mitochondrial dysfunction, oxidative stress, and abnormal protein aggregation. Surprisingly, both necrotic and apoptotic processes utilize a similar

Gabor Medal (738 words) [view diff] exact match in snippet view article find links to article

2018 — Cait MacPhee "for her seminal contributions to understanding protein aggregation that informed our approach to diseases such as Alzheimer's and diabetes

ACYP2 (668 words) [view diff] exact match in snippet view article find links to article

Relini A, Stefani M, Chiti F, Dobson CM (Feb 2005). "Reversal of protein aggregation provides evidence for multiple aggregated States". Journal of Molecular

Arimoclomol (841 words) [view diff] exact match in snippet view article find links to article

treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS". J. Neurochem. 107 (2): 339–50. doi:10

Cryogenic electron microscopy (2,514 words) [view diff] exact match in snippet view article find links to article

rounds of screening and optimization to overcome issues such as protein aggregation and preferred orientations, but it does not require the sample to

Hofmeister series (1,603 words) [view diff] exact match in snippet view article find links to article

denaturing a reference protein. At high salt concentrations lysozyme protein aggregation obeys the Hofmeister series originally observed by Hofmeister in

N-linked glycosylation (2,510 words) [view diff] exact match in snippet view article find links to article

PMID 15959882. "N-glycosylation as a eukaryotic protective mechanism against protein aggregation". Science Advances. 10 (5). 2024. doi:10.1126/sciadv.adk8173. PMC 10830103

Carol K. Hall (632 words) [view diff] exact match in snippet view article find links to article

Physical Society in 2007, "for creating a new paradigm to simulate protein aggregation through a combination of intermediate-resolution molecular models

Priyanka Joshi (449 words) [view diff] exact match in snippet view article find links to article

body, such as metabolites, and their potential role in preventing protein aggregation in the brain. Joshi has also been involved in public engagement work

SeqA protein (521 words) [view diff] exact match in snippet view article find links to article

Lee H, Kang S, Bae SH, Choi BS, Hwang DS (September 2001). "SeqA protein aggregation is necessary for SeqA function". The Journal of Biological Chemistry

Prion (10,631 words) [view diff] exact match in snippet view article find links to article

domain that is both necessary and sufficient for self-templating and protein aggregation. This has been shown by attaching the prion domain to a reporter

Respiratory burst (2,555 words) [view diff] exact match in snippet view article find links to article

bonds, inducing protein crosslinking. Both oxidations result in protein aggregation, and ultimately, cell death. Sulfhydryl groups can be oxidised up

Renee Wegrzyn (409 words) [view diff] exact match in snippet view article find links to article

2022-09-12. 'Genetic, biochemical, and physiological study of yeast prion protein aggregation' (Ph.D. Thesis, Georgia Institute of Technology, 2003) "Biden appoints

Daniel I.C. Wang (443 words) [view diff] exact match in snippet view article find links to article

utilization, enzyme technology, product recovery and purification, protein aggregation and refolding, and mammalian cell cultures made him a pioneer in

Low complexity regions in proteins (3,569 words) [view diff] exact match in snippet view article find links to article

A, Bukau B (November 2010). "Cellular strategies for controlling protein aggregation". Nature Reviews Molecular Cell Biology. 11 (11): 777–788. doi:10

UBQLN1 (1,428 words) [view diff] exact match in snippet view article find links to article

"Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation". Biochemical Society Transactions. 38 (Pt 1): 150–5. doi:10.1042/BST0380150

Low-voltage electron microscope (1,045 words) [view diff] exact match in snippet view article find links to article

"Low-Voltage Electron Microscopy (LVEM) as a probe for solubilized membrane protein aggregation states". Microscopy and Microanalysis. 10 (2): 1492–1493. Bibcode:2004MiMic

Henry L. Paulson (458 words) [view diff] exact match in snippet view article find links to article

Medicine for his "work in making fundamental discoveries regarding protein aggregation and nucleotide repeat expansions as causes of neurodegenerative diseases

Fungal prion (2,734 words) [view diff] exact match in snippet view article find links to article

are good models for studying factors like chaperones that affect protein aggregation. Also, the IPOD is the sub-cellular site to which amyloidogenic proteins

Inclusion bodies (2,545 words) [view diff] exact match in snippet view article find links to article

Saunders. ISBN 978-1-4160-2973-1. 8th edition. Ross, Poirier (2004). "Protein aggregation and neurodegenerative disease". Nature Medicine. 10 Suppl: S10-7

Dagmar Ringe (570 words) [view diff] exact match in snippet view article find links to article

Parkinson's. She has also discovered potential new drugs to stop the protein aggregation that leads to Alzheimer's disease. Biophysical Society Margaret Oakley

Amyloidosis (5,432 words) [view diff] exact match in snippet view article find links to article

are sporadic and have a late age of onset – in these cases, the protein aggregation may be associated with aging-related decline in protein regulation

Kang Zhang (2,573 words) [view diff] exact match in snippet view article find links to article

Zhang L, Liu Y, Yan YB, Zhang K (July 2015). "Lanosterol reverses protein aggregation in cataracts". Nature. 523 (7562): 607–11. Bibcode:2015Natur.523

Amy Gladfelter (2,038 words) [view diff] case mismatch in snippet view article find links to article

Occhipinti, Patricia; Borsuk, Mark E.; Gladfelter, Amy S. (2013). "Protein Aggregation Behavior Regulates Cyclin Transcript Localization and Cell-Cycle

Protein precipitation (2,041 words) [view diff] exact match in snippet view article find links to article

with hydrophobic patches on other proteins. These salts enhance protein aggregation and precipitation. Chaotropes or "water structure breakers," have

Deinococcus radiodurans (4,527 words) [view diff] exact match in snippet view article find links to article

Goyal K, Walton LJ, Tunnacliffe A (2005). "LEA proteins prevent protein aggregation due to water stress". Biochemical Journal. 388 (Pt 1): 151–157. doi:10

Ataxin 1 (1,998 words) [view diff] exact match in snippet view article find links to article

S2CID 68966133. Shastry BS (July 2003). "Neurodegenerative disorders of protein aggregation". Neurochemistry International. 43 (1): 1–7. doi:10.1016/s0197-0186(02)00196-1

Rohit Pappu (958 words) [view diff] exact match in snippet view article find links to article

contributions to understanding the driving forces associated with protein aggregation, and how the linear amino acid sequence of a disordered proteins

Acyl-CoA:lysocardiolipin acyltransferase-1 (946 words) [view diff] exact match in snippet view article find links to article

muscle fibers. Additionally, inhibition of ALCAT1 prevented SOD1 protein aggregation and attenuated skeletal muscle atrophy in SOD1 transgenic mice. Accumulating

Huntingtin (3,255 words) [view diff] case mismatch in snippet view article find links to article

Medicine Medical Subject Headings (MeSH) The Huntingtin Protein and Protein Aggregation at HOPES : Huntington's Outreach Project for Education at Stanford

Pasta (7,909 words) [view diff] exact match in snippet view article find links to article

in grains such as wheat, rye, spelt, and barley, contributes to protein aggregation and firm texture of a normally cooked pasta. Gluten-free pasta is

SMURF1 (1,916 words) [view diff] exact match in snippet view article find links to article

SMURF1 may be a potential target for therapeutic intervention in protein aggregation and improving cellular proteostasis in neurodegenerative diseases

Inclusion body myositis (3,621 words) [view diff] exact match in snippet view article find links to article

emphasizes the abnormal intracellular accumulation of many proteins, protein aggregation and misfolding, proteosome inhibition, and endoplasmic reticulum

Subunit vaccine (6,747 words) [view diff] exact match in snippet view article find links to article

by epigenetic gene silencing and aggresome formation (recombinant protein aggregation). For mammalian cells, synthesised proteins were reported to be secreted

Drug discovery (6,730 words) [view diff] exact match in snippet view article find links to article

find compounds which reverse a disease phenotype such as death, protein aggregation, mutant protein expression, or cell proliferation as examples in

Major prion protein (5,228 words) [view diff] exact match in snippet view article find links to article

PMID 16313516. S2CID 24329326. Ross CA, Poirier MA (July 2004). "Protein aggregation and neurodegenerative disease". Nat. Med. 10 (7): S10–7. doi:10.1038/nm1066

Animal models of Parkinson's disease (3,147 words) [view diff] exact match in snippet view article find links to article

knockout models have also been studied and show the increase of protein aggregation and accumulation which also includes α-synuclein; but, it does not

Rotenone (3,299 words) [view diff] exact match in snippet view article find links to article

pathology. However at least one study recently has found evidence of protein aggregation of the same chemical makeup as that which makes up Lewy bodies with

Heat shock protein (5,497 words) [view diff] exact match in snippet view article find links to article

of proper protein conformation (shape) and prevention of unwanted protein aggregation. By helping to stabilize partially unfolded proteins, HSPs aid in

Anne Bertolotti (1,340 words) [view diff] exact match in snippet view article find links to article

for identifying components of cellular defense mechanisms against protein aggregation and for the discovery of strategies to rescue cell survival under

Athene Donald (2,450 words) [view diff] exact match in snippet view article find links to article

to the study of both synthetic and biological systems, notably protein aggregation. Further details of her research can be found in the citation for

Bacterial senescence (1,332 words) [view diff] case mismatch in snippet view article find links to article

Demarez, A.; Dimiccoli, M.; Julou, T.; et al. (2013). "Localization of Protein Aggregation in Escherichia coli Is Governed by Diffusion and Nucleoid Macromolecular

Variant Creutzfeldt–Jakob disease (4,484 words) [view diff] case mismatch in snippet view article find links to article

Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Disease". Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. Subcellular

Li Gan (1,113 words) [view diff] exact match in snippet view article find links to article

studies how mechanisms of proteostasis can contribute to pathogenic protein aggregation. Her lab demonstrated that cathepsin B (CatB) can degrade Aβ, the

Marc Baldus (1,223 words) [view diff] exact match in snippet view article find links to article

technology amongst others to study the behavior of bacterial proteins, protein aggregation in Alzheimer's and Parkinson's disease, to study the effect of sugars

Molecular recognition feature (1,194 words) [view diff] exact match in snippet view article find links to article

"Intrinsically semi-disordered state and its role in induced folding and protein aggregation". Cell Biochemistry and Biophysics. 67 (3): 1193–205. doi:10.1007/s12013-013-9638-0

Aldehyde dehydrogenase 3 family, member A1 (2,547 words) [view diff] exact match in snippet view article find links to article

structure. This loss of secondary and tertiary structure leads to protein aggregation and complete loss of enzymatic activity. Peptide mapping and spectroscopic

Pierre Goloubinoff (977 words) [view diff] exact match in snippet view article find links to article

discoveries on the mechanisms of various molecular chaperones that prevent protein aggregation, promote protein folding, actively solubilize stable aggregates and

Custirsen (1,232 words) [view diff] exact match in snippet view article find links to article

by the inhibition of the pro-apoptotic BLC2 gene, prevention of protein aggregation, and increased NF-KB. The anti-apoptotic activity of clusterin in

Annalisa Pastore (714 words) [view diff] exact match in snippet view article find links to article

molecular basis of neurodegeneration. She looks at diseases caused by protein aggregation, including Huntington's disease and Machado–Joseph disease. She also

Proteostasis (2,922 words) [view diff] exact match in snippet view article find links to article

proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation". eLife. 5: 15550. doi:10.7554/elife.15550. PMC 4954754. PMID 27435961

NPM1 (4,897 words) [view diff] exact match in snippet view article find links to article

chaperone activity. NPM1 has been predicted to play a role in preventing protein aggregation in the densely packed nucleolus especially during ribosome biogenesis

TMEM61 (1,231 words) [view diff] case mismatch in snippet view article find links to article

Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains SARS1 Host organism: Saccharomyces cerevisiae

LONP1 (1,773 words) [view diff] exact match in snippet view article find links to article

(December 2015). "LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins"

Sonia Gandhi (scientist) (865 words) [view diff] exact match in snippet view article

Gandhi". UCL. Retrieved 2020-06-01. ""The toxic consequences of protein aggregation in Parkinson's disease"". Oxford Parkinson's Disease Centre. Retrieved

Photo-induced cross-linking of unmodified proteins (1,588 words) [view diff] exact match in snippet view article find links to article

Parkinson's disease, and Huntington's disease, that result from protein aggregation. PICUP is extremely important when possible prevention and treatment

Protein folding (8,653 words) [view diff] exact match in snippet view article find links to article

many disease causing mutants which were assumed to be involved in protein aggregation, however the mechanism was still unknown. By using Relaxation Dispersion

Raffaele Mezzenga (940 words) [view diff] exact match in snippet view article find links to article

contributions to several fields of soft condensed matter such as in protein aggregation, biopolymers and surfactants self-organisation. He has pioneered

Proteinopathy (4,592 words) [view diff] exact match in snippet view article find links to article

chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways". Prion. 3 (2): 51–8. doi:10.4161/pri.3.2.8587. PMC 2712599

Sarah L. Keller (1,014 words) [view diff] exact match in snippet view article find links to article

phases—miscibility transition. Her works contributed to models of protein aggregation within membranes and the theory of membrane lateral pressure. Her

Ehud Gazit (1,412 words) [view diff] exact match in snippet view article find links to article

This achievement is a far-reaching extension of the concept of protein aggregation to include a significantly larger class of biomolecules that form

Alzheimer's disease (19,087 words) [view diff] exact match in snippet view article find links to article

Hashimoto M, Rockenstein E, Crews L, Masliah E (2003). "Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's

Proline-rich 12 (1,301 words) [view diff] exact match in snippet view article find links to article

these proteins to fold properly and allowing the possibility of protein aggregation. Residues such as G, A, S, Y, and P are listed as poor protectors

Chaperome (733 words) [view diff] exact match in snippet view article find links to article

chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways". Prion. 3 (2): 51–58. doi:10.4161/pri.3.2.8587. PMC 2712599

Justin Yerbury (1,601 words) [view diff] exact match in snippet view article find links to article

included protein misfolding, aggregation and neurodegenerative disease, protein aggregation and neuro-inflammation and the Propagation of protein misfolding

Solid-state nuclear magnetic resonance (5,299 words) [view diff] exact match in snippet view article find links to article

membrane proteins and amyloid fibrils. The latter topic relates to protein aggregation diseases such as Alzheimer's disease and Parkinson's disease. Solid-state

Primary age-related tauopathy (2,126 words) [view diff] exact match in snippet view article find links to article

immunofluorescence tools have allowed researchers to identify and observe tau protein aggregation both intra and intercellullary as well as their interaction with

Parkin (protein) (5,731 words) [view diff] exact match in snippet view article

accumulation of soluble proteins that overloads the proteasome. Protein aggregation triggers neuronal toxicity, whilst accounting for lack of ubiquitinated

Mission Discovery (1,133 words) [view diff] exact match in snippet view article find links to article

Alzheimer's disease - An experiment to compare the rate of Amyloid beta protein aggregation on earth vs in a microgravity environment 2015 Caerphilly, UK Suns

GrpE (2,679 words) [view diff] exact match in snippet view article find links to article

serve a similar function as GrpE, to protect the cell from unfolded protein aggregation. These nucleotide exchange factors always interact with subdomain

Cell cycle hypothesis of Alzheimer's disease (1,669 words) [view diff] exact match in snippet view article find links to article

reduced clearance of toxin, mitochondrial dysfunction, DNA damage, protein aggregation. Despite a growing number of studies underlying caspases and apoptosis

CD4 immunoadhesin (2,878 words) [view diff] case mismatch in snippet view article find links to article

Li, Ning; Speaker, Stan (2010-08-05), "External Factors Affecting Protein Aggregation", Aggregation of Therapeutic Proteins, Hoboken, NJ, USA: John Wiley

Discodermolide (3,460 words) [view diff] exact match in snippet view article find links to article

delivered. The presence of Amyloid in the cell could lead to tau protein aggregation and microtubule numbers reduction. In transgenic mouse model for

Bacterial effector protein (3,130 words) [view diff] exact match in snippet view article find links to article

lysine, serine or threonine residues with an acetyl group, leading to protein aggregation, blockage of phosphorylation or inhibition of ATP binding. In plants

Methods to investigate protein–protein interactions (4,494 words) [view diff] exact match in snippet view article find links to article

much harder to determine for concentrated protein solutions when protein aggregation, not merely transient protein association, is often the dominant

Nediljko Budisa (2,131 words) [view diff] exact match in snippet view article find links to article

to our understanding of the role of methionine oxidation in prion protein aggregation and has discovered the roles of proline side chain conformations

DISC1 (4,723 words) [view diff] exact match in snippet view article find links to article

a common link with other neurological disorders characterised by protein aggregation, namely Alzheimer's disease, Parkinson's disease, and Huntington's

Nikolay Dokholyan (1,728 words) [view diff] exact match in snippet view article find links to article

etiology, and found out that oxidative stress and aging are linked to protein aggregation. Dokholyan described the toxicity of nonnative SOD1 trimer in terms

Protein moonlighting (5,101 words) [view diff] exact match in snippet view article find links to article

crystallin using its non-refractive ability within the lens to prevent protein aggregation under a variety of environmental stresses and to protect against

Biochemistry of Alzheimer's disease (7,745 words) [view diff] exact match in snippet view article find links to article

Hashimoto M, Rockenstein E, Crews L, Masliah E (2003). "Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's

Timeline of aging research (17,253 words) [view diff] exact match in snippet view article find links to article

"Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes". Nature Aging. 3 (5): 546–566

VPS35 (4,050 words) [view diff] exact match in snippet view article find links to article

including vesicular trafficking, plasma membrane receptor recycling, protein aggregation, mitochondrial function, and dopamine signaling. These processes

Epigenetic regulation of neurogenesis (5,725 words) [view diff] case mismatch in snippet view article find links to article

Boyd JT, Hamill RW, Maguire-Zeiss KA (2012). "Parkinson's Disease". Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. Subcellular

2023 in science (44,436 words) [view diff] exact match in snippet view article find links to article

"Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes". Nature Aging. 3 (5): 546–566

Spinocerebellar ataxia type 1 (10,375 words) [view diff] exact match in snippet view article find links to article

PMID 27440721. Shastry BS (July 2003). "Neurodegenerative disorders of protein aggregation". Neurochemistry International. 43 (1): 1–7. doi:10.1016/S0197-0186(02)00196-1

De novo gene birth (13,530 words) [view diff] exact match in snippet view article find links to article

“self-evidently deleterious” variants, such as those prone to lead to protein aggregation, and thus enriched in potential adaptations relative to a completely

Nerve guidance conduit (14,559 words) [view diff] exact match in snippet view article find links to article

under mechanical shear force, which leads to lateral packing and protein aggregation of fibers. Phillips et al. showed that mechanical shear produced

Cluster of Excellence Frankfurt Macromolecular Complexes (15,450 words) [view diff] exact match in snippet view article find links to article

Kehrloesser S, Schäfer B, Güntert P, Sinha S, Dötsch V, Missero (2018). "Protein aggregation of the p63 transcription factor underlies severe skin fragility in