malignant hyperthermia (MH), central core disease (CCD), Brody disease and phospholamban, and applying his knowledge of the gene in MH to develop accurate diagnosis
suggested to play a role in the development of heart failure. Modulated by phospholamban (PLB), SERCA2 regulates uptake of Ca2+ into the sarcoplasmic reticulum
Waggott D, Fu J, et al. (July 2009). "Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three
Souchet M, Camelin JC, et al. (1998). "Biophysical interaction between phospholamban and protein phosphatase 1 regulatory subunit GM". FEBS Lett. 439 (3):
nonmyocytes. The production of PKA results in the phosphorylation of phospholamban and inhibition of its block on the sarcoendoplasmic reticulum calcium
Ruiz-Lozano P (March 2005). "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum"
form of dilated cardiomyopathy due to a mutation in gene encoding the Phospholamban protein. Further activation proved therapeutic in a human induced pluripotent
particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury". Journal of Molecular and Cellular
Jin M, Namekata I, Mototani Y, et al. (June 2014). "Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses". The Journal
interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart". Biochemical and Biophysical Research Communications