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searching for PALB2 14 found (42 total)

alternate case: pALB2

Bing Xia (694 words) [view diff] exact match in snippet view article find links to article

he directs the Xia Laboratory. He is best known for his discovery of the PALB2 tumor suppressor gene, a notable scientific advance in the field of cancer

Genetic heterogeneity (1,248 words) [view diff] exact match in snippet view article find links to article

rare cancer syndromes. Mutations in CHECK2, ATM, NBS1, RAD50, BRIP1, and PALB2 can double the risk of breast cancer development. Biallelic mutations, in

FANCL (1,374 words) [view diff] exact match in snippet view article find links to article

1182/blood-2002-01-0278. PMID 12239151. Park JY, Zhang F, Andreassen PR (2014). "PALB2: the hub of a network of tumor suppressors involved in DNA damage responses"

Fanconi anemia (4,138 words) [view diff] exact match in snippet view article find links to article

FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (BRIP1), FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (XPF), FANCS (BRCA1), FANCT (UBE2T)

University of Medicine and Dentistry of New Jersey (2,163 words) [view diff] exact match in snippet view article find links to article

Rutgers Cancer Institute of New Jersey, known for his discovery of the PALB2 tumor suppressor gene Marilyn Kozak, RWJMS Professor of Biochemistry, discoverer

Mouse avatars (637 words) [view diff] exact match in snippet view article find links to article

al: Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer

Shapiro–Senapathy algorithm (6,804 words) [view diff] exact match in snippet view article find links to article

different splice sites in various genes causing breast cancer (e.g., BRCA1, PALB2), ovarian cancer (e.g., SLC9A3R1, COL7A1, HSD17B7), colon cancer (e.g.,

Protein-truncating variants (590 words) [view diff] exact match in snippet view article find links to article

Shahana (2017-11-01). "Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks". Journal

CHEK2 (2,797 words) [view diff] exact match in snippet view article find links to article

A, et al. (August 2019). "Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative

Enhancer of polycomb homolog 2 (drosophila) (516 words) [view diff] exact match in snippet view article

Shinmyozu K, Nakayama J, Andreassen PR (April 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal

Kelly Metcalfe (962 words) [view diff] exact match in snippet view article find links to article

another grant to fund her study, Breast cancer treatment in women with PALB2 mutations. In 2018, Metcalfe was appointed Acting Associate Dean, Research

Bert Vogelstein (3,823 words) [view diff] exact match in snippet view article find links to article

Hruban RH, Kamiyama M, et al. (April 2009). "Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene". Science. 324 (5924): 217. Bibcode:2009Sci

Talazoparib (1,230 words) [view diff] exact match in snippet view article find links to article

genes (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) were assessed prospectively using tumor tissue and/or circulating

Double-strand break repair model (4,324 words) [view diff] exact match in snippet view article find links to article

phosphorylates BRCA1. Ubiquinated FANCD2 complexes with BRCA1 and RAD51. The PALB2 protein acts as a hub, bringing together BRCA1, BRCA2 and RAD51 at the site