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searching for Orphan 533 found (110679 total)

alternate case: orphan

Orphan Black (7,966 words) [view diff] exact match in snippet view article find links to article

Orphan Black is a Canadian science fiction thriller television series created by screenwriter Graeme Manson and director John Fawcett, starring Tatiana
Diageo (2,713 words) [view diff] no match in snippet view article find links to article
Diageo plc (/diˈædʒioʊ/) is a British multinational beverage alcohol company, with its headquarters in London, England. It operates in more than 180 countries
Tatiana Maslany (3,426 words) [view diff] exact match in snippet view article find links to article
playing multiple characters in the science fiction thriller television series Orphan Black (2013–2017), which won her a Primetime Emmy Award (2016), a TCA Award
RTGame (261 words) [view diff] exact match in snippet view article find links to article
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Rare disease (1,664 words) [view diff] exact match in snippet view article find links to article
affects a small percentage of the population. In some parts of the world, an orphan disease is a rare disease whose rarity means there is a lack of a market
Annie (musical) (7,025 words) [view diff] exact match in snippet view article
Broadway musical based upon the popular Harold Gray comic strip Little Orphan Annie, with music by Charles Strouse, lyrics by Martin Charnin, and book
Orphan drug (3,948 words) [view diff] exact match in snippet view article find links to article
An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without
Temple Riders (113 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
Acronym (14,266 words) [view diff] exact match in snippet view article find links to article
"K9" (kay-nine) for "canine". Pseudo-acronyms also frequently develop as "orphan initialisms"; an existing acronym is redefined as a non-acronymous name
European Medicines Agency (2,370 words) [view diff] exact match in snippet view article find links to article
CHMP as described above. The Committee on Orphan Medicinal Products (COMP) administers the granting of orphan drug status since 2000. Companies intending
Little Orphan Annie (7,469 words) [view diff] exact match in snippet view article find links to article
Little Orphan Annie is a daily American comic strip created by Harold Gray and syndicated by the Tribune Media Services. The strip took its name from the
Rogue planet (2,762 words) [view diff] exact match in snippet view article find links to article
interstellar planet, nomad planet, free-floating planet, unbound planet, orphan planet, wandering planet, starless planet, or sunless planet) is a planetary-mass
RAR-related orphan receptor gamma (2,311 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is member of the
Cassandra Cain (5,942 words) [view diff] exact match in snippet view article find links to article
have assumed the role of Batgirl, and Cassandra Cain goes by the name of Orphan in DC Comics' current continuity. Cassandra's origin story presents her
RAR-related orphan receptor (1,107 words) [view diff] exact match in snippet view article find links to article
The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR
RAR-related orphan receptor beta (934 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans
Tom Sawyer (479 words) [view diff] no match in snippet view article find links to article
Thomas Sawyer (/ˈsɔːjər/) is the title character of the Mark Twain novel The Adventures of Tom Sawyer (1876). He appears in three other novels by Twain:
Orphan receptor (727 words) [view diff] exact match in snippet view article find links to article
a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan". Conversely, the term orphan ligand refers to
Neuron-derived orphan receptor 1 (1,265 words) [view diff] exact match in snippet view article find links to article
The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded
RAR-related orphan receptor alpha (2,659 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is
Lord Voldemort (7,895 words) [view diff] no match in snippet view article find links to article
Lord Voldemort (/ˈvoʊldəmɔːr/, /-mɔːrt/ in the films) is a sobriquet for Tom Marvolo Riddle, a fictional character and the main antagonist in J. K. Rowling's
Orphan work (1,449 words) [view diff] exact match in snippet view article find links to article
An orphan work is a copyright-protected work for which rightsholders are positively indeterminate or uncontactable. Sometimes the names of the originators
Retinoic acid-inducible orphan G protein-coupled receptor (367 words) [view diff] exact match in snippet view article find links to article
The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression
AstraZeneca (4,985 words) [view diff] exact match in snippet view article find links to article
would partner with Orca Pharmaceuticals to develop retinoic acid-related orphan nuclear receptor gamma inhibitors for use in the treatment of a number of
Orphan (2009 film) (1,941 words) [view diff] exact match in snippet view article
Orphan is a 2009 psychological horror film directed by Jaume Collet-Serra and written by David Leslie Johnson from a story by Alex Mace. The film stars
Oliver Twist (5,974 words) [view diff] exact match in snippet view article find links to article
three-volume book in 1838, before the serialization ended. The story centres on orphan Oliver Twist, born in a workhouse and sold into apprenticeship with an undertaker
Johns Hopkins (4,036 words) [view diff] exact match in snippet view article find links to article
female orphans principally as domestic workers, and next as an "orthopedic convalescent" home and school for "colored crippled" children and orphans. The
Small heterodimer partner (1,664 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
X-Statix (2,280 words) [view diff] exact match in snippet view article find links to article
Allred. The storyline (which features the returns of the Anarchist, the Orphan, and U-Go Girl) parodies the manner in which creators in the industry handle
Widows and orphans (891 words) [view diff] exact match in snippet view article find links to article
In typesetting, widows and orphans are lines at the beginning or end of a paragraph which are left dangling at the top or bottom of a page or column,
Orphanet (121 words) [view diff] exact match in snippet view article find links to article
Orphanet is a European website providing information about orphan drugs and rare diseases. It contains content both for physicians and for patients. Its
Testicular receptor 2 (922 words) [view diff] exact match in snippet view article find links to article
1016/S0006-291X(89)80028-2. PMID 2597158. Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate
Amgen (2,536 words) [view diff] exact match in snippet view article find links to article
Swedish Orphan Biovitrum, in December 2008) Kineret (anakinra) for rheumatoid arthritis, exclusively licensed to Biovitrium, now Swedish Orphan Biovitrum
Elizabeth Schuyler Hamilton (4,348 words) [view diff] exact match in snippet view article find links to article
is recognized as an early American philanthropist for her work with the Orphan Asylum Society. Elizabeth was born in Albany, New York, the second daughter
Rev-ErbA alpha (2,063 words) [view diff] exact match in snippet view article find links to article
these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite
Sodium oxybate (3,993 words) [view diff] exact match in snippet view article find links to article
approved for treating symptoms of narcolepsy in the European Union in 2005. Orphan Medical had developed it and was acquired by Jazz Pharmaceuticals in 2005
Hydrocortisone (949 words) [view diff] no match in snippet view article find links to article
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital
Gord the Rogue (1,642 words) [view diff] exact match in snippet view article find links to article
novel, Dance of Demons. The series of novels follows the progress of the orphan beggar Gord, from his lowly youth to his ascension as an avatar of Balance
Lyra Belacqua (1,478 words) [view diff] no match in snippet view article find links to article
Lyra Belacqua (/ˈlaɪrə bəˈlɑːkwə/), also known as Lyra Silvertongue, is the heroine of Philip Pullman's His Dark Materials trilogy. In His Dark Materials
Orphan Girl at the Cemetery (331 words) [view diff] exact match in snippet view article find links to article
The Orphan Girl at the cemetery (also known as Young Orphan Girl in the Cemetery; French: Jeune orpheline au cimetière) (c. 1823 or 1824) is a painting
Depatuxizumab mafodotin (217 words) [view diff] exact match in snippet view article find links to article
Depatux-M after late-stage failure in newly diagnosed glioblastoma. In 2014, Orphan Drug Status was granted by the FDA for glioblastoma multiforme. It is in
Solriamfetol (521 words) [view diff] exact match in snippet view article find links to article
adults with narcolepsy or obstructive sleep apnea (OSA). It was granted orphan drug designation. The U.S. Food and Drug Administration (FDA) approved solriamfetol
Han Solo (4,399 words) [view diff] exact match in snippet view article find links to article
Alden Ehrenreich. In the film, 19-year old Han is characterized to be an orphan on the planet Corellia. He and his lover, Qi'ra (Emilia Clarke), attempt
Nuclear receptor (6,288 words) [view diff] exact match in snippet view article find links to article
target nuclear receptors. A number of nuclear receptors, referred to as orphan receptors, have no known (or at least generally agreed upon) endogenous
Tetrabenazine (562 words) [view diff] no match in snippet view article find links to article
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others
Methotrexate (2,745 words) [view diff] no match in snippet view article find links to article
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases
Reed's School (2,737 words) [view diff] exact match in snippet view article find links to article
forming an educational institution to assist orphaned children. A month later, on 27 July the East London Orphan Asylum was formally established. Reed gave
Isabelle Fuhrman (1,190 words) [view diff] exact match in snippet view article find links to article
actress. She is best known for her roles as Esther in the 2009 horror film Orphan, and Clove in the 2012 dystopian adventure film The Hunger Games. She also
Annie (2014 film) (3,754 words) [view diff] exact match in snippet view article
musical of the same name (which in turn is based on the comic strip Little Orphan Annie by Harold Gray), the film stars Quvenzhané Wallis in the title role
Amifampridine (3,083 words) [view diff] exact match in snippet view article find links to article
Amifampridine phosphate has orphan drug status in the EU for Lambert–Eaton myasthenic syndrome and Catalyst holds both an orphan designation and a breakthrough
Vesper Lynd (1,776 words) [view diff] no match in snippet view article find links to article
Vesper Lynd is a fictional character featured in Ian Fleming's 1953 James Bond novel Casino Royale. She was portrayed by Ursula Andress in the 1967 James
AbbVie (1,909 words) [view diff] no match in snippet view article find links to article
AbbVie is an American publicly traded biopharmaceutical company founded in 2013. It originated as a spin-off of Abbott Laboratories. On October 19, 2011
Huckleberry Finn (1,539 words) [view diff] no match in snippet view article find links to article
Huckleberry "Huck" Finn is a fictional character created by Mark Twain who first appeared in the book The Adventures of Tom Sawyer (1876) and is the protagonist
Midway University (1,578 words) [view diff] exact match in snippet view article find links to article
working adults. Midway University originally opened as the Kentucky Female Orphan School on October 3, 1849, with one teacher and sixteen female students
Ambrisentan (555 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) and the European Medicines Agency (EMA), and designated an orphan drug, for the treatment of pulmonary hypertension. Ambrisentan is indicated
Testicular receptor 4 (1,132 words) [view diff] exact match in snippet view article find links to article
Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings
The Orphan Master's Son (1,040 words) [view diff] exact match in snippet view article find links to article
The Orphan Master's Son is a 2012 novel by American author Adam Johnson. It deals with intertwined themes of propaganda, identity, and state power in North
Class C GPCR (248 words) [view diff] exact match in snippet view article find links to article
(GRM5) mGluR6 (GRM6) mGluR7 (GRM7) mGluR8 (GRM8) Retinoic acid-inducible orphan G protein-coupled receptors (RAIG) RAIG1 (GPRC5A) RAIG2 (GPRC5B) RAIG3 (GPRC5C)
Colchicine (4,838 words) [view diff] exact match in snippet view article find links to article
exclusivity for Colcrys in treatment of familial Mediterranean fever, under the Orphan Drug Law. URL Pharma then raised the price per tablet from $0.09 to $4.85
Nerve growth factor IB (2,333 words) [view diff] exact match in snippet view article find links to article
homodimer to NurRE. It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription
Sotalol (1,504 words) [view diff] no match in snippet view article find links to article
Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. It is only recommended in those
Terguride (198 words) [view diff] exact match in snippet view article find links to article
attenuation of disease progression. In May 2008, terguride was granted orphan drug status for the treatment of pulmonary arterial hypertension. In May
NAGly receptor (1,037 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous
Estrogen-related receptor (1,158 words) [view diff] exact match in snippet view article find links to article
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of
COUP-TFII (1,544 words) [view diff] exact match in snippet view article find links to article
PMID 8530078. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development"
Orphan of the Pecos (697 words) [view diff] exact match in snippet view article find links to article
Orphan of the Pecos is a 1937 American Western film produced and directed by Sam Katzman and starring Tom Tyler, Jeanne Martel, Howard Bryant, and Forrest
Superfund (5,027 words) [view diff] exact match in snippet view article find links to article
is allocable among PRPs in contribution based on comparative fault. An "orphan share" is the share of costs at a Superfund site that is attributable to
Itachi Uchiha (3,126 words) [view diff] no match in snippet view article find links to article
Itachi Uchiha (Japanese: うちは イタチ, Hepburn: Uchiha Itachi) is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto. Itachi
Rifaximin (1,835 words) [view diff] exact match in snippet view article find links to article
rifaximin should be avoided in such cases. In the United States, rifaximin has orphan drug status for the treatment of hepatic encephalopathy. Although high-quality
Itraconazole (2,189 words) [view diff] exact match in snippet view article find links to article
"Itraconazole Orphan Drug Designation". U.S. Food and Drug Administration (FDA). 19 May 2016. Retrieved 15 May 2020. "Itraconazole Orphan Drug Designation"
Glutamine (2,088 words) [view diff] exact match in snippet view article find links to article
extremities, back pain and chest pain. L-glutamine oral powder received orphan drug designation. The FDA granted the approval of Endari to Emmaus Medical
Reoviridae (1,777 words) [view diff] exact match in snippet view article find links to article
tract. The name "reo-" is an acronym for "respiratory enteric orphan" viruses. The term "orphan virus" refers to the fact that some of these viruses have
Eculizumab (2,880 words) [view diff] exact match in snippet view article find links to article
tax incentives in the Orphan Drug Act of 1983. On average the cost per person for orphan drugs is "six times that of non-orphan drugs, a clear indication
Liver receptor homolog-1 (1,314 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
Pramiracetam (398 words) [view diff] exact match in snippet view article find links to article
Phase II trials showed mixed results; it then began to develop it as an orphan drug as an adjunct to electroconvulsive therapy for major depressive disorder
Benralizumab (222 words) [view diff] exact match in snippet view article find links to article
2017 for the treatment of severe eosinophilic asthma. It was also granted orphan drug designation by the FDA for treatment of eosinophilic oesophagitis in
Sodium thiosulfate (1,376 words) [view diff] no match in snippet view article find links to article
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na2S2O3.xH2O. Typically it is available as the white or colorless pentahydrate
Emapalumab (474 words) [view diff] exact match in snippet view article find links to article
into smaller peptides via the body's normal catabolism. The FDA awarded orphan drug status in 2012, and breakthrough therapy designation in 2016 on the
Stiripentol (1,072 words) [view diff] exact match in snippet view article find links to article
December 2001, the European Medicines Agency (EMA) granted stiripentol orphan drug status (designation number EU/3/01/071) for the treatment of severe
Anagrelide (876 words) [view diff] exact match in snippet view article find links to article
Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (also
Burosumab (757 words) [view diff] exact match in snippet view article find links to article
April 2018. The FDA approval fell under both the breakthrough therapy and orphan drug designations. It was approved for use in the European Union in February
SREB (130 words) [view diff] exact match in snippet view article find links to article
ligands have yet been identified for these receptors, they are classified as orphan receptors. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi
Estrogen-related receptor alpha (2,006 words) [view diff] exact match in snippet view article find links to article
that estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor. ERRα has wide tissue distribution but it is most highly
MRGPRG (138 words) [view diff] exact match in snippet view article find links to article
(GPR169) is a protein that in humans is encoded by the MRGPRG gene. MRGG is an orphan G-protein coupled receptor. GRCh38: Ensembl release 89: ENSG00000182170
Estrogen-related receptor gamma (1,269 words) [view diff] exact match in snippet view article find links to article
hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists
Alvocidib (485 words) [view diff] exact match in snippet view article find links to article
(formerly Tolero Pharmaceuticals Inc.) announced that the FDA has granted orphan drug designation for Alvocidib, its cyclin-dependent kinase small molecule
Tom and Jerry filmography (802 words) [view diff] exact match in snippet view article find links to article
intro theme used in most Hanna-Barbera shorts and beyond. 40 The Little Orphan April 30, 1949 In this Thanksgiving short, Jerry and Nibbles dine on Thanksgiving
Teduglutide (297 words) [view diff] exact match in snippet view article find links to article
restoring gastric emptying and secretion. In Europe it has been granted orphan drug status and is marketed under the brand Revestive by Nycomed. It was
Bosentan (1,060 words) [view diff] no match in snippet view article find links to article
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery
Alvocidib (485 words) [view diff] exact match in snippet view article find links to article
(formerly Tolero Pharmaceuticals Inc.) announced that the FDA has granted orphan drug designation for Alvocidib, its cyclin-dependent kinase small molecule
Pfizer (11,060 words) [view diff] no match in snippet view article find links to article
Coordinates: 41°20′04″N 72°04′05″W / 41.3343429°N 72.06795°W / 41.3343429; -72.06795 Pfizer Inc. (/ˈfaɪzər/) is an American multinational pharmaceutical
Hannibal Lecter (6,074 words) [view diff] exact match in snippet view article find links to article
from his birth into an aristocratic family in Lithuania in 1933, to being orphaned, along with his beloved younger sister Mischa, in 1944 when a Nazi Stuka
Bosentan (1,060 words) [view diff] no match in snippet view article find links to article
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery
Mitotane (767 words) [view diff] exact match in snippet view article find links to article
has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in
Orphan Train (4,962 words) [view diff] exact match in snippet view article find links to article
The Orphan Train Movement was a supervised welfare program that transported orphaned and homeless children from crowded Eastern cities of the United States
Awful Orphan (634 words) [view diff] exact match in snippet view article find links to article
Awful Orphan is a 1949 Warner Bros. Merrie Melodies cartoon, directed by Chuck Jones and written by Michael Maltese. It is a sequel to the 1947 Looney
Three Orphan Kittens (1,209 words) [view diff] exact match in snippet view article find links to article
Three Orphan Kittens is a 1935 animated short film in the Silly Symphonies series produced by Walt Disney Productions. It was the winner of the 1935 Oscar
Larotrectinib (412 words) [view diff] exact match in snippet view article find links to article
licensed to Loxo Oncology in 2013. Larotrectinib was initially awarded orphan drug status in 2015, for soft tissue sarcoma, and breakthrough therapy designation
GPR148 (297 words) [view diff] exact match in snippet view article find links to article
G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and
Abandonware (8,704 words) [view diff] exact match in snippet view article find links to article
abandonware is a software (or hardware) sub-case of the general concept of orphan works. Museums and various organizations, dedicated to preserving this software
Little Orphan Airedale (225 words) [view diff] exact match in snippet view article find links to article
Little Orphan Airedale is a Warner Bros. Looney Tunes cartoon directed by Charles M. Jones and released on October 4, 1947. Its major significance is its
Biogen (2,225 words) [view diff] exact match in snippet view article find links to article
hemophilia B 2014 1993 Also approved in Canada and Australia. Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization
GPR158 (386 words) [view diff] exact match in snippet view article find links to article
protein that in humans is encoded by the GPR158 gene. This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7
Iduronidase (2,065 words) [view diff] exact match in snippet view article find links to article
enjoys orphan drug status in both the United States and the European Union, though in both its orphan drug exclusivity period has expired. (Orphan drug
Teprotumumab (837 words) [view diff] exact match in snippet view article find links to article
Phase I for diabetic macular edema. It was granted Breakthrough Therapy, Orphan Drug Status and Fast Track designations by the FDA for Graves' ophthalmopathy
List of Dove Medical Press academic journals (672 words) [view diff] exact match in snippet view article find links to article
Statistics† Open Access Rheumatology: Research and Reviews Open Access Surgery Orphan Drugs: Research and Reviews† Orthopedic Research and Reviews Pathology and
Ibalizumab (653 words) [view diff] exact match in snippet view article find links to article
trial for s.c. and i.m. injection dosage forms (on-going). 2014: granted orphan drug designation for HIV MDR patients by U.S. FDA. 2015: granted breakthrough
GPR12 (319 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR12 gene. The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene
Often an Orphan (595 words) [view diff] exact match in snippet view article find links to article
Often an Orphan is a 1949 cartoon in the Merrie Melodies series. The cartoon was released on August 13, 1949 and stars Charlie Dog and Porky Pig. The cartoon
Wedge Antilles (1,858 words) [view diff] no match in snippet view article find links to article
Wedge Antilles is a fictional character in the Star Wars franchise. He is a supporting character portrayed by Denis Lawson in the original Star Wars trilogy
Institut Catholique de Paris (1,262 words) [view diff] no match in snippet view article find links to article
The Institut Catholique de Paris (ICP), known in English as the Catholic University of Paris (and in Latin as Universitas catholica Parisiensis), is a
Olaratumab (896 words) [view diff] exact match in snippet view article find links to article
2010. In February 2015, the European Medicines Agency assigned olaratumab orphan drug status for the treatment of soft-tissue sarcoma. The European Commission
Lombard, Illinois (2,023 words) [view diff] exact match in snippet view article find links to article
Gray's parents and the studio of Harold Gray, the originator of Little Orphan Annie cartoon strip. Harold Gray used the home's study to work on the Annie
Rituximab (3,615 words) [view diff] no match in snippet view article find links to article
Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for
The Little Orphan (1,251 words) [view diff] exact match in snippet view article find links to article
The Little Orphan is a 1949 American one-reel animated cartoon and the 40th Tom and Jerry cartoon, released in theaters on April 30, 1949 by Metro-Goldwyn
Lenvatinib (887 words) [view diff] exact match in snippet view article find links to article
treating thyroid cancer patients started in March 2011. Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not
Freddy Krueger (4,695 words) [view diff] no match in snippet view article find links to article
Freddy Krueger (/ˈkruːɡər/) is a fictional character in the A Nightmare on Elm Street film series. He first appeared in Wes Craven's A Nightmare on Elm
Vera Farmiga (7,109 words) [view diff] exact match in snippet view article find links to article
Primetime Emmy Award nomination. These roles, along with Joshua (2007) and Orphan (2009), established her as a scream queen. For her portrayal of a lawyer
Tucatinib (1,156 words) [view diff] exact match in snippet view article find links to article
application for tucatinib priority review, breakthrough therapy, fast track, and orphan drug designations. The FDA granted approval of Tukysa to Seattle Genetics
GPRC5A (689 words) [view diff] exact match in snippet view article find links to article
dysregulated in many human cancers and in other diseases. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000013588 -
Eltrombopag (789 words) [view diff] exact match in snippet view article find links to article
collaboration between GlaxoSmithKline and Ligand Pharmaceuticals. Designated an orphan drug in the United States and European Union, it is being manufactured and
Mowgli (2,026 words) [view diff] no match in snippet view article find links to article
Mowgli /ˈmaʊɡli/ is a fictional character and the protagonist of Rudyard Kipling's The Jungle Book stories. He is a feral boy from the Pench area in Seoni
The Orphan of Zhao (2,734 words) [view diff] exact match in snippet view article find links to article
The Orphan of Zhao is a Chinese play from the Yuan era, attributed to the 13th-century dramatist Ji Junxiang (紀君祥). The play has as its full name The Great
Rey (Star Wars) (6,989 words) [view diff] exact match in snippet view article
side to fight being weakened by his pain. Rey is first introduced as an orphan living alone on the desert planet Jakku, scraping a living through scavenging
Quasimodo (2,980 words) [view diff] exact match in snippet view article find links to article
where he is found abandoned in Notre Dame (on the foundlings' bed, where orphans and unwanted children are left to public charity) on Quasimodo Sunday,
General German Protestant Orphans Home (141 words) [view diff] exact match in snippet view article find links to article
General German Protestant Orphans Home, also known as the Pleasant Run Children's Home , is a historic orphanage located at Indianapolis, Indiana. It
Misty (Pokémon) (1,967 words) [view diff] no match in snippet view article
Misty, known as Kasumi (カスミ) in Japan, is a fictional character in the Pokémon franchise owned by Nintendo and created by Satoshi Tajiri. She has appeared
Tails (Sonic the Hedgehog) (3,060 words) [view diff] no match in snippet view article
Miles "Tails" Prower (Japanese: マイルス "テイルス" パウアー, Hepburn: Mairusu "Teirusu" Pauā) is a fictional character in Sega's Sonic the Hedgehog series, and the
Track gauge conversion (792 words) [view diff] exact match in snippet view article find links to article
gauge conversion work, some stations and branch lines may become "gauge orphans". Trains can't operate to them until costly gauge conversion work is completed
Matt Frewer (1,750 words) [view diff] exact match in snippet view article find links to article
icon Max Headroom and Doctor Leekie in the Canadian science fiction drama Orphan Black (2013–2017). Frewer's more recent performances include a portrayal
Fasudil (817 words) [view diff] no match in snippet view article find links to article
Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which
Neuropeptides B/W receptor 1 (1,058 words) [view diff] exact match in snippet view article find links to article
When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8, but at least three groups in
Tocilizumab (3,082 words) [view diff] exact match in snippet view article find links to article
older. In 2011 the US FDA approved tocilizumab for the treatment of the orphan disease, active systemic juvenile idiopathic arthritis (SJIA), a rare and
GPRC5C (644 words) [view diff] exact match in snippet view article find links to article
different isoforms have been found for this gene. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000170412 -
Budesonide (2,266 words) [view diff] no match in snippet view article find links to article
Budesonide (BUD), sold under the brand name Pulmicort among others, is a medication of the corticosteroid type. It is available as an inhaler, pill, nasal
GPR50 (768 words) [view diff] exact match in snippet view article find links to article
MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through
Cabozantinib (1,408 words) [view diff] exact match in snippet view article find links to article
KIT), and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib was granted orphan drug status by the U.S. Food and Drug Administration (FDA) in November 2010
Break of gauge (5,997 words) [view diff] exact match in snippet view article find links to article
new gauge. These severed branches can be called gauge orphans. The opposite of a gauge orphan is a line of one gauge which reaches into the territory
Thiotepa (612 words) [view diff] exact match in snippet view article find links to article
29, 2007, the European Medicines Agency (EMA) designated thiotepa as an orphan drug. On April 2, 2007, the United States FDA designated thiotepa as a conditioning
Thiotepa (612 words) [view diff] exact match in snippet view article find links to article
29, 2007, the European Medicines Agency (EMA) designated thiotepa as an orphan drug. On April 2, 2007, the United States FDA designated thiotepa as a conditioning
Elesclomol (647 words) [view diff] exact match in snippet view article find links to article
GlaxoSmithKline as a chemotherapy adjuvant, and has received both fast track and orphan drug status from the U.S. Food and Drug Administration for the treatment
Genentech (3,004 words) [view diff] no match in snippet view article find links to article
Genentech, Inc., is an American biotechnology corporation which became a subsidiary of Roche in 2009. Genentech Research and Early Development operates
Nintedanib (2,666 words) [view diff] exact match in snippet view article find links to article
nintedanib group compared to the placebo group. Nintedanib was granted orphan drug designation in the US by the FDA for the treatment of idiopathic pulmonary
Arylsulfatase B (1,817 words) [view diff] exact match in snippet view article find links to article
Galsulfase (N-acetylgalactosamine-4-sulfatase, recombinant human) was granted orphan drug designation by both the European Commission and the U.S. Food and Drug
Romiplostim (564 words) [view diff] exact match in snippet view article find links to article
(immune) thrombocytopenic purpura (ITP). Romiplostim was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2003, as the chronic
Foster care (7,737 words) [view diff] exact match in snippet view article find links to article
1392-1490s in Japan. The foster care system in Japan is similar to the Orphan Trains because Brace thought the children would be better off on farms.
Altretamine (524 words) [view diff] no match in snippet view article find links to article
Altretamine (trade name Hexalen) is an antineoplastic agent. It was approved by the U.S. FDA in 1990. It is indicated for use as a single agent in the
Posaconazole (651 words) [view diff] no match in snippet view article find links to article
Posaconazole, sold under the brand names Noxafil and Posanol is a triazole antifungal medication. It was approved for medical use in the United States
Rev-ErbA beta (845 words) [view diff] exact match in snippet view article find links to article
Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (August 1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb"
Gemtuzumab ozogamicin (1,157 words) [view diff] no match in snippet view article find links to article
Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute
Neuromedin U receptor 1 (437 words) [view diff] exact match in snippet view article find links to article
(Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and
GPRC5B (345 words) [view diff] exact match in snippet view article find links to article
acid on the G protein signal transduction cascade. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000167191 -
Inuktitut Braille (759 words) [view diff] exact match in snippet view article find links to article
Commonwealth Braille and Talking Book Cooperative. The book ᐃᓕᐊᕐᔪᒃ ᓇᓄᕐᓗ The Orphan and the Polar Bear was the first (and perhaps only) work transliterated
The Devil's Hands Are Idle Playthings (1,290 words) [view diff] no match in snippet view article find links to article
"The Devil's Hands Are Idle Playthings" is the final episode in the fourth season of the American animated television series Futurama, and the finale of
Ripretinib (1,039 words) [view diff] exact match in snippet view article find links to article
fast track designations, as well as breakthrough therapy designation and orphan drug designation. The FDA granted approval of Qinlock to Deciphera Pharmaceuticals
Annie (1999 film) (1,941 words) [view diff] exact match in snippet view article
Martin Charnin, and Thomas Meehan, which in turn is based on the 1924 Little Orphan Annie comic strip by Harold Gray. It was directed by Rob Marshall, written
Vertex Pharmaceuticals (3,049 words) [view diff] exact match in snippet view article find links to article
Executive Chairman until April 2023. In 2012 ivacaftor, was designated as an orphan drug, identifying cystic fibrosis as affecting fewer than 200,000 people
2nd Canadian Screen Awards (243 words) [view diff] exact match in snippet view article find links to article
10 categories, while on the television side the science fiction series Orphan Black was nominated in 14 categories. The awards ceremony were hosted by
Honey Ryder (1,083 words) [view diff] exact match in snippet view article find links to article
shell diver, descended from an old-established colonial family. She was orphaned at the age of five when her parents' house was burned down. She then lived
Doctor Who (series 12) (4,616 words) [view diff] exact match in snippet view article
"Spyfall, Part 2". James Buckley appeared in "Orphan 55" as Nevi. Laura Fraser also appeared in "Orphan 55" as Kane, as did Julia Foster as Vilma. Goran
Merck & Co. (7,766 words) [view diff] exact match in snippet view article find links to article
antibody-drug conjugate, VLS-101, designed to target Tyrosine kinase-like orphan receptor 1 (ROR1) in both hematological and solid tumors. VLS-101 is currently
Vorinostat (1,091 words) [view diff] no match in snippet view article find links to article
Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds
Dacomitinib (263 words) [view diff] no match in snippet view article find links to article
Dacomitinib, sold under the brand name Vizimpro, is a medication for the treatment of non-small-cell lung carcinoma (NSCLC). It is a selective and irreversible
Constitutive androstane receptor (2,200 words) [view diff] exact match in snippet view article find links to article
Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD (Mar 1994). "A new orphan member of the nuclear hormone receptor superfamily that interacts with a
Novo Nordisk (1,944 words) [view diff] no match in snippet view article find links to article
Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd, Denmark, with production facilities in eight countries, and
Mepolizumab (979 words) [view diff] no match in snippet view article find links to article
Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis
5th Canadian Screen Awards (493 words) [view diff] exact match in snippet view article find links to article
ceremony, the film It's Only the End of the World and the television series Orphan Black won the most awards in film and television categories, with six and
Fenfluramine (2,540 words) [view diff] exact match in snippet view article find links to article
"Fenfluramine Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 25 June 2020. "Fenfluramine Orphan Drug
Brigatinib (668 words) [view diff] exact match in snippet view article find links to article
application to the US FDA on August 29, 2016. In 2016, brigatinib was granted orphan drug status by the FDA for treatment of NSCLC. In 28 April 2017, it was
Orphan School Creek (130 words) [view diff] exact match in snippet view article find links to article
33°52′58″S 151°10′34″E / 33.882663°S 151.176219°E / -33.882663; 151.176219 Orphan School Creek is a storm drain located in inner Sydney, New South Wales.
Avelumab (1,431 words) [view diff] exact match in snippet view article find links to article
targets the protein programmed death-ligand 1 (PD-L1). It has received orphan drug designation by the European Medicines Agency (EMA) for the treatment
John Hunt Morgan (3,209 words) [view diff] no match in snippet view article find links to article
John H. Morgan (June 1, 1825 – September 4, 1864) was a Confederate general in the American Civil War. In April 1862, he raised the 2nd Kentucky Cavalry
Batman and Robin Eternal (1,124 words) [view diff] exact match in snippet view article find links to article
one of Mother's agents calling himself the Orphan. Cassandra Cain saves her, then chases after the Orphan. Dick meets Harper and her roommate Stephanie
Venetoclax (2,322 words) [view diff] exact match in snippet view article find links to article
and accelerated approval along with breakthrough therapy designation and orphan drug designation. Venetoclax was approved for use in the European Union
GPR35 (1,124 words) [view diff] exact match in snippet view article find links to article
including the crypts of Lieberkühn. Although GPR35 is still considered an orphan receptor, there have been attempts to deorphanize it by identifying endogenous
GPR75 (239 words) [view diff] exact match in snippet view article find links to article
proteins upon the binding of a ligand. GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study
Orion Arm (968 words) [view diff] exact match in snippet view article find links to article
interstellar masers in HMSFRs have been shown that the Local arm appears to be an orphan segment of an arm between the Sagittarius and Perseus arms that wraps around
Edward Cullen (3,679 words) [view diff] no match in snippet view article find links to article
Edward Cullen (né Edward Anthony Masen, Jr.) is a fictional character in Stephenie Meyer's Twilight series. He is featured in the books Twilight, New Moon
Orochimaru (Naruto) (3,843 words) [view diff] no match in snippet view article
Orochimaru (大蛇丸) is a fictional character from the Naruto manga, created by Masashi Kishimoto. In the anime and manga, Orochimaru is a former ninja from
Wanda Maximoff (Marvel Cinematic Universe) (3,899 words) [view diff] no match in snippet view article
Wanda Maximoff is a character portrayed by Elizabeth Olsen in the Marvel Cinematic Universe (MCU) media franchise who is based on the Marvel Comics character
Orphan School Creek (Fairfield) (197 words) [view diff] exact match in snippet view article
Orphan School Creek is a tributary of Prospect Creek, located entirely within the City of Fairfield, NSW. It starts in Allambie Road Reserve, Bossley Park
Peeta Mellark (2,596 words) [view diff] no match in snippet view article find links to article
Peeta Mellark is a fictional character from The Hunger Games trilogy by Suzanne Collins. He is portrayed by actor Josh Hutcherson in The Hunger Games film
Kato (The Green Hornet) (3,146 words) [view diff] no match in snippet view article
Kato is a fictional character from The Green Hornet series. This character has appeared with the Green Hornet in film, television, book and comic book
Margo Martindale (1,630 words) [view diff] exact match in snippet view article find links to article
Lorenzo's Oil, ...First Do No Harm, Eye of God, Win Win, Marvin's Room, Forged, Orphan, The Savages, Hannah Montana: The Movie, August: Osage County, and Paris
Echovirus (295 words) [view diff] exact match in snippet view article find links to article
enteric disease in humans. The name is derived from "enteric cytopathic human orphan virus". These viruses were originally not associated with disease but many
GPR182 (993 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. When this gene was first cloned, it was proposed
Kato (The Green Hornet) (3,146 words) [view diff] no match in snippet view article
Kato is a fictional character from The Green Hornet series. This character has appeared with the Green Hornet in film, television, book and comic book
GPR182 (993 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. When this gene was first cloned, it was proposed
Carboprost (554 words) [view diff] no match in snippet view article find links to article
Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α)
Carmustine (514 words) [view diff] no match in snippet view article find links to article
Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound
Boba Fett (8,370 words) [view diff] no match in snippet view article find links to article
Boba Fett (/ˌboʊbə ˈfɛt/) is a fictional character in the Star Wars franchise created by George Lucas. He is a Mandalorian armor-wearing bounty hunter
Icatibant (496 words) [view diff] exact match in snippet view article find links to article
effects of icatibant on the bradykinin B1 receptor. Icatibant received orphan drug status in Australia, the EU, Switzerland and the US for the treatment
Pimozide (962 words) [view diff] exact match in snippet view article find links to article
schizophrenia. In 1985 the pimozide was approved by the FDA for marketing as an orphan drug for the treatment of Tourette's syndrome. Medicine portal Amisulpride
Selpercatinib (1,112 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for selpercatinib priority review, orphan drug, and breakthrough therapy designations and granted approval of Retevmo
GPR64 (1,153 words) [view diff] exact match in snippet view article find links to article
GPCR-Autoproteolysis INducing (GAIN) domain. The adhesion GPCR, GPR64, is an orphan receptor characterized by a long N-terminus with that has been suggested
Hoffmann-La Roche (4,138 words) [view diff] no match in snippet view article find links to article
Coordinates: 47°33′31″N 7°36′22″E / 47.558624°N 7.606018°E / 47.558624; 7.606018 F. Hoffmann-La Roche AG is a Swiss multinational healthcare company
Green Hornet (4,147 words) [view diff] exact match in snippet view article find links to article
Team Venture. It is also revealed that Blue Morpho was the father of the orphaned villain The Monarch, and he and Henchman 21 later take on the roles of
Daratumumab (1,539 words) [view diff] exact match in snippet view article find links to article
breakthrough therapy drug status in 2013, for multiple myeloma. It was awarded orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular
Melatonin (9,115 words) [view diff] no match in snippet view article find links to article
Melatonin is a hormone primarily released by the pineal gland that regulates the sleep–wake cycle. As a dietary supplement, it is often used for the short-term
Capmatinib (956 words) [view diff] exact match in snippet view article find links to article
approval program and granted the application for capmatinib priority review, orphan drug, and breakthrough therapy designations and granted the approval of
Like Mike (1,131 words) [view diff] exact match in snippet view article find links to article
Lipnicki, Robert Forster, Crispin Glover and Eugene Levy, the film follows an orphan who gets basketball talents after finding a pair of Michael Jordan's shoes
Trabectedin (1,502 words) [view diff] exact match in snippet view article find links to article
European Commission and the U.S. Food and Drug Administration (FDA) granted orphan drug status to trabectedin for soft-tissue sarcomas and ovarian cancer.
Tetrahydrobiopterin (2,425 words) [view diff] no match in snippet view article find links to article
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation
Pemtumomab (151 words) [view diff] exact match in snippet view article find links to article
2009[update], it is undergoing Phase III clinical trials. It has been granted orphan drug status in Europe. Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas
Peter Sarsgaard (4,664 words) [view diff] exact match in snippet view article find links to article
films such as Flightplan (2005), Jarhead (2005), The Skeleton Key (2005), Orphan (2009), An Education (2009), Knight and Day (2010), Green Lantern (2011)
Rhoticity in English (7,260 words) [view diff] exact match in snippet view article find links to article
as boss–bourse. Specifically, the phonemic merger of the words often and orphan was a running gag in the Gilbert and Sullivan musical, The Pirates of Penzance
Treprostinil (1,571 words) [view diff] exact match in snippet view article find links to article
Patient Package Insert. United Therapeutics Corp. 2013. Rare Disease and Orphan Drug Designated Approvals 2013 "Orenitram" (PDF). Full Prescribing Information
GPRC5D (221 words) [view diff] exact match in snippet view article find links to article
function of this gene has not yet been determined. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000111291 -
Shelleyan Orphan (762 words) [view diff] exact match in snippet view article find links to article
Shelleyan Orphan were a British alternative music group that peaked during the 1980s and early 1990s. In 1980, Caroline Crawley and Jemaur Tayle met in
Pazopanib (1,267 words) [view diff] no match in snippet view article find links to article
Pazopanib, sold under the brand name Votrient, is an anti-cancer medication. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor
Binandere language (200 words) [view diff] exact match in snippet view article find links to article
(Guhu-Samane burisi eetaqu ‘turn over, turn s.th. around’) *mbeŋga-masi ‘orphan’, ‘widow and child’ (Suena boga masa ‘destitute widow and child’) *pu +
Peter Parker (Marvel Cinematic Universe) (4,432 words) [view diff] exact match in snippet view article
on which he had collaborated with Joe Simon in the 1950s, in which an orphaned boy living with an old couple finds a magic ring that granted him superhuman
Sanofi (7,500 words) [view diff] exact match in snippet view article find links to article
headquartered in Cambridge, Massachusetts specializes in the treatment of orphan diseases, renal diseases, endocrinology, oncology and biosurgery. In January
Laura Dern (2,704 words) [view diff] exact match in snippet view article find links to article
She received an Academy Award nomination for her portrayal of the titular orphan in the drama film Rambling Rose (1991) and achieved international recognition
Thomas John Barnardo (1,552 words) [view diff] exact match in snippet view article find links to article
Victorian London. Many of these children were not only impoverished, but orphaned, as the result of a recent cholera outbreak. For those unable to afford
Daddy Warbucks (1,374 words) [view diff] exact match in snippet view article find links to article
Oliver "Daddy" Warbucks is a fictional character from the comic strip Little Orphan Annie. He made his first appearance in the New York Daily News in the Annie
Winston Smith (797 words) [view diff] no match in snippet view article find links to article
Winston Smith is a fictional character and the protagonist of George Orwell's dystopian 1949 novel Nineteen Eighty-Four. The character was employed by
Park County, Colorado (1,178 words) [view diff] exact match in snippet view article find links to article
been and is the location of several important mines, including the defunct Orphan Boy, which was discovered near Alma in 1861 and produced gold, silver, lead
Rucaparib (1,100 words) [view diff] exact match in snippet view article find links to article
pretreated advanced ovarian cancer. In the European Union it was designated an orphan medicinal product on 10 October 2012. On 22 March 2018, the Committee for
Ixazomib (1,570 words) [view diff] exact match in snippet view article find links to article
can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative. The
GPR15 (1,448 words) [view diff] exact match in snippet view article find links to article
GPR15 is a class A orphan G protein-coupled receptor (heterotrimeric guanine nucleotide-binding protein, GPCR). The GPR15 gene is localized at chromosome
Gaara (3,895 words) [view diff] no match in snippet view article find links to article
Gaara (我愛羅) is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto. Originally debuting as an antagonist, Gaara is
Busulfan (1,212 words) [view diff] no match in snippet view article find links to article
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific
Durvalumab (736 words) [view diff] no match in snippet view article find links to article
Durvalumab (trade name Imfinzi) is an FDA-approved immunotherapy for cancer, developed by Medimmune/AstraZeneca. It is a human immunoglobulin G1 kappa
Charlie Dog (820 words) [view diff] exact match in snippet view article find links to article
two more Charlie Dog/Porky Pig cartoons in 1949: Awful Orphan (29 January) and Often an Orphan (13 August). Jones also starred Charlie without Porky in
Cromoglicic acid (1,144 words) [view diff] no match in snippet view article find links to article
Cromoglicic acid (INN) (also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate) is traditionally described as a mast cell stabilizer
List of Drawn Together episodes (176 words) [view diff] exact match in snippet view article find links to article
Musical number: "The Board of Education" and "Fire the Load" 10 3 "Little Orphan Hero" Ray Claffey Erik Sommers November 2, 2005 (2005-11-02) 203 After discovering
Pregnane X receptor (1,962 words) [view diff] exact match in snippet view article find links to article
Watson MA, Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene
Qi'ra (2,353 words) [view diff] exact match in snippet view article find links to article
Wars Anthology film Solo: A Star Wars Story, Qi'ra is introduced as an orphaned street thief living on the shipbuilding world of Corellia. She and her
Trehalose (1,793 words) [view diff] no match in snippet view article find links to article
Trehalose (from Turkish 'trehala' – a sugar derived from insect cocoons + -ose) is a sugar consisting of two molecules of glucose. It is also known as
Receptor tyrosine kinase-like orphan receptor (85 words) [view diff] exact match in snippet view article find links to article
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in
Actelion (2,449 words) [view diff] exact match in snippet view article find links to article
Actelion focuses on the manufacture of drugs that treat rare diseases and orphan diseases.[failed verification] Some of the drugs it has produced have been
Chlormethine (1,654 words) [view diff] no match in snippet view article find links to article
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard
STI College (569 words) [view diff] exact match in snippet view article find links to article
administration, and computer science. The acronym STI has been declared as an orphan initialism after their name change in 2006. STI uses a trimester calendar
Sorafenib (2,446 words) [view diff] no match in snippet view article find links to article
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary
Cannabidiol (8,048 words) [view diff] exact match in snippet view article find links to article
Sjögren S, Hjorth S, Hermansson NO, Leonova J, et al. (December 2007). "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology
Chlormethine (1,654 words) [view diff] no match in snippet view article find links to article
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard
Istiratumab (75 words) [view diff] exact match in snippet view article find links to article
ErbB3. It is in development by Merrimack Pharmaceuticals and was awarded orphan drug status for pancreatic cancer. Alternative Names: MM-141. "Istiratumab
Cromoglicic acid (1,144 words) [view diff] no match in snippet view article find links to article
Cromoglicic acid (INN) (also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate) is traditionally described as a mast cell stabilizer
Iloprost (1,219 words) [view diff] no match in snippet view article find links to article
Iloprost is a drug used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels
STI College (569 words) [view diff] exact match in snippet view article find links to article
administration, and computer science. The acronym STI has been declared as an orphan initialism after their name change in 2006. STI uses a trimester calendar
Michiel Huisman (1,829 words) [view diff] exact match in snippet view article find links to article
television such as Liam McGuinnis on Nashville (2012–14) and as Cal Morrison on Orphan Black (2014–15). Huisman began his career on Dutch television, in the Dutch
F-15,599 (568 words) [view diff] exact match in snippet view article find links to article
gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease. F-15,599 was discovered and initially developed by Pierre Fabre
Naxitamab (247 words) [view diff] exact match in snippet view article find links to article
the application for naxitamab priority review, breakthrough therapy, and, orphan drug designations. The FDA issued a priority review voucher for this rare
Elotuzumab (231 words) [view diff] no match in snippet view article find links to article
Elotuzumab (brand name Empliciti, (Bristol-Myers Squibb and AbbVie), previously known as HuLuc63) is a humanized monoclonal antibody used in relapsed multiple
Remdesivir (7,957 words) [view diff] exact match in snippet view article find links to article
as a result of the outbreak in the Czech Republic. On 17 February 2016, orphan designation (EU/3/16/1615) was granted by the European Commission to Gilead
TLX (934 words) [view diff] exact match in snippet view article find links to article
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and Cellular Biology. 20 (23): 8731–9.
Pitolisant (732 words) [view diff] exact match in snippet view article find links to article
U.S. Food and Drug Administration (FDA) in August 2019. It was granted orphan drug designation for the treatment of narcolepsy, fast track designation
Cladribine (3,082 words) [view diff] exact match in snippet view article find links to article
pharmaceutical companies were interested in selling the drug because HCL was an orphan disease, so Beutler's lab synthesized and packaged it and supplied it to
ViroPharma (766 words) [view diff] exact match in snippet view article find links to article
Makiko (11 November 2013). "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg. Pollack, Andrew (9 November 2005). "Crucial Antibiotic
Metreleptin (511 words) [view diff] no match in snippet view article find links to article
Metreleptin, sold under the brand name Myalept among others, is a synthetic analog of the hormone leptin used to treat various forms of dyslipidemia. It
3rd Canadian Screen Awards (206 words) [view diff] exact match in snippet view article find links to article
13 nominations, while on the television side the science fiction series Orphan Black also received 13 nominations. The awards ceremony were hosted by Andrea
Omacetaxine mepesuccinate (769 words) [view diff] no match in snippet view article find links to article
Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated
Dasatinib (1,924 words) [view diff] no match in snippet view article find links to article
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy used to treat certain cases of chronic myelogenous leukemia (CML) and
Tolvaptan (572 words) [view diff] exact match in snippet view article find links to article
the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant
Nitisinone (869 words) [view diff] exact match in snippet view article find links to article
nitisinone being brought to market as an orphan drug Swedish Orphan International, which was later acquired by Swedish Orphan Biovitrum (Sobi).[citation needed]
Margetuximab (199 words) [view diff] exact match in snippet view article find links to article
progress for gastric cancer and esophageal cancer. In June 2020, it received orphan drug designation from the U.S. Food and Drug Administration (FDA). Statement
Bombesin-like receptor 3 (796 words) [view diff] exact match in snippet view article find links to article
therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor. GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
Niraparib (740 words) [view diff] no match in snippet view article find links to article
Niraparib (trade name Zejula) is an orally active small molecule PARP inhibitor developed by Tesaro to treat ovarian cancer. Niraparib was granted fast
Alexion Pharmaceuticals (2,591 words) [view diff] no match in snippet view article find links to article
Alexion Pharmaceuticals Inc. is an American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical
Takeda Pharmaceutical Company (2,146 words) [view diff] no match in snippet view article find links to article
The Takeda Pharmaceutical Company Limited (武田薬品工業株式会社, Takeda Yakuhin Kōgyō kabushiki gaisha) [takeꜜda jakɯçiŋ koꜜːɡʲoː] is a Japanese multinational pharmaceutical
Runaway (dependent) (1,585 words) [view diff] no match in snippet view article
A runaway is a minor or (depending upon the local jurisdiction) a person under a specified age, who has left their parents or legal guardians without permission
Mecasermin rinfabate (1,225 words) [view diff] no match in snippet view article find links to article
Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor
Adam Johnson (writer) (1,419 words) [view diff] exact match in snippet view article
and short story writer. He won the Pulitzer Prize for his 2012 novel, The Orphan Master's Son, and the National Book Award for his 2015 story collection
Treosulfan (498 words) [view diff] exact match in snippet view article find links to article
fludarabine) were alive 3 months after their transplant. On 23 February 2004, orphan designation (EU/3/04/186) was granted by the European Commission to medac
Sacituzumab govitecan (1,057 words) [view diff] exact match in snippet view article find links to article
small cell lung cancer, and metastatic triple-negative breast cancer. Orphan drug status was granted for small cell lung cancer and pancreatic cancer
Inigo Montoya (931 words) [view diff] no match in snippet view article find links to article
Inigo Montoya is a fictional character in William Goldman's 1973 novel The Princess Bride. In Rob Reiner's 1987 film adaptation, he was portrayed by Mandy
Romidepsin (1,416 words) [view diff] exact match in snippet view article find links to article
designation from the FDA for the treatment of cutaneous T-cell lymphoma, and orphan drug status from the FDA and the European Medicines Agency for the same
Al-Ma'un (1,475 words) [view diff] exact match in snippet view article find links to article
denieth the future judgment as a falsehood? ۝ It is he who pusheth away the orphan; ۝ and stirreth not up others to feed the poor. ۝ Woe be unto those who
Sookie Stackhouse (3,081 words) [view diff] no match in snippet view article find links to article
Sookie Stackhouse is a fictional character and protagonist of The Southern Vampire Mysteries book series, written by Charlaine Harris. In HBO's television
Rifampicin (4,541 words) [view diff] no match in snippet view article find links to article
Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections, including tuberculosis, Mycobacterium avium complex
Shire (pharmaceutical company) (2,126 words) [view diff] exact match in snippet view article
Retrieved 26 March 2016. "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg. 11 November 2013. Retrieved 26 March 2016. Trista Kelley
Huerfano Butte (354 words) [view diff] exact match in snippet view article find links to article
Walsenburg in Huerfano County, Colorado, United States. Named Huerfano (English: orphan) by early Spanish explorers, it rises above the south side of the Huerfano
Huerfano County, Colorado (1,182 words) [view diff] exact match in snippet view article find links to article
Walsenburg. The county, whose name comes from the Spanish huérfano meaning "orphan", was named for the Huerfano Butte, a local landmark. The area of Huerfano
Bortezomib (2,130 words) [view diff] no match in snippet view article find links to article
Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma. This
Liver X receptor (2,755 words) [view diff] exact match in snippet view article find links to article
cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands
Polatuzumab vedotin (517 words) [view diff] exact match in snippet view article find links to article
vedotin-piiq breakthrough therapy designation, priority review designation, and orphan drug designation. The FDA granted the approval of Polivy to Genentech. Polatuzumab
CCH Pounder (1,027 words) [view diff] exact match in snippet view article find links to article
Joon (1993), Demon Knight (1995), Face/Off (1997), End of Days (1999), Orphan (2009), Avatar (2009), The Mortal Instruments: City of Bones (2013), and
Silly Symphony (1,828 words) [view diff] exact match in snippet view article find links to article
to this include Three Little Pigs, The Tortoise and the Hare, and Three Orphan Kittens, which all had sequels). The series is notable for its innovation
GPR55 (1,690 words) [view diff] exact match in snippet view article find links to article
a relevant role in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in oncology
Picornavirales (407 words) [view diff] exact match in snippet view article find links to article
picorna- is an acronym for poliovirus, insensitivity to ether, coxsackievirus, orphan virus, rhinovirus, and ribonucleic acid. Secondly, pico-, meaning extremely
Pembrolizumab (5,062 words) [view diff] exact match in snippet view article find links to article
studies to ensure that the results are valid. Pembrolizumab was granted orphan drug designation for SCLC in October 2017. In June 2018, the US FDA approved
Jyn Erso (2,310 words) [view diff] no match in snippet view article find links to article
Jyn Erso is a fictional character in the Star Wars franchise, portrayed by English actress Felicity Jones in the 2016 film Rogue One. Jyn aids the Rebel
New York City draft riots (4,486 words) [view diff] exact match in snippet view article find links to article
various abolitionists or sympathizers, many black homes, and the Colored Orphan Asylum at 44th Street and Fifth Avenue, which was burned to the ground.
Paromomycin (1,396 words) [view diff] no match in snippet view article find links to article
Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection.
KiSS1-derived peptide receptor (1,897 words) [view diff] exact match in snippet view article find links to article
suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry.
Germ cell nuclear factor (914 words) [view diff] exact match in snippet view article find links to article
Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated
Ranibizumab (1,924 words) [view diff] no match in snippet view article find links to article
Ranibizumab (trade name Lucentis among others) is a monoclonal antibody fragment (Fab) created from the same parent mouse antibody as bevacizumab. It is
Inebilizumab (848 words) [view diff] exact match in snippet view article find links to article
and Drug Administration (FDA) granted the application for inebilizumab orphan drug designation and granted approval of Uplizna to Viela Bio. Inebilizumab
Iva Toguri D'Aquino (2,810 words) [view diff] exact match in snippet view article find links to article
during World War II on The Zero Hour radio show. Toguri called herself "Orphan Ann", but she quickly became inaccurately identified with the name "Tokyo
Small nucleolar RNA (3,571 words) [view diff] exact match in snippet view article find links to article
loops in the snoRNA sequence. However, there are increasing numbers of 'orphan' guides without any known RNA targets, which suggests that there might be
V-erbA-related gene (1,014 words) [view diff] exact match in snippet view article find links to article
Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear
Sasuke Uchiha (9,233 words) [view diff] no match in snippet view article find links to article
Sasuke Uchiha (Japanese: うちは サスケ, Hepburn: Uchiha Sasuke) (/ˈsɑːskeɪ/) is a fictional character in the Naruto manga and anime franchise created by Masashi
4th Canadian Screen Awards (372 words) [view diff] exact match in snippet view article find links to article
Ari Millen, Orphan Black Aaron Poole, Strange Empire Adrian Holmes, 19-2 Ben Bass, Rookie Blue Jared Keeso, 19-2 Tatiana Maslany, Orphan Black Jennie
Tiopronin (561 words) [view diff] exact match in snippet view article find links to article
rarity of the disorder, tiopronin falls under the classification of an orphan drug. It is somewhat similar to penicillamine in both chemistry and pharmacology
Nilotinib (1,709 words) [view diff] no match in snippet view article find links to article
Nilotinib, sold under the brand name Tasigna, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It
Naruto Uzumaki (13,043 words) [view diff] exact match in snippet view article find links to article
felt it was something common in Japanese series. Introduced as a young orphan boy of 12 years with blond, spiky hair, blue eyes and goggles, Naruto Uzumaki
ROR2 (1,109 words) [view diff] exact match in snippet view article find links to article
brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
GPR1 (581 words) [view diff] exact match in snippet view article find links to article
PMC 2224232. PMID 18165312. Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication
The Shakespeare Stealer (611 words) [view diff] exact match in snippet view article find links to article
place in the Elizabethan-era England, it recounts the story of Widge, an orphan whose master sends him to steal Hamlet from The Lord Chamberlain's Men.
Otelixizumab (678 words) [view diff] exact match in snippet view article find links to article
failed to show efficacy of the treatment. Otelixizumab has been granted "orphan drug" status by the U.S. Food and Drug Administration. As a monoclonal antibody
Monster Study (2,105 words) [view diff] exact match in snippet view article find links to article
The Monster Study was a stuttering experiment performed on 22 orphan children in Davenport, Iowa in 1939. It was conducted by Wendell Johnson at the University
GPR42 (224 words) [view diff] exact match in snippet view article find links to article
PMID 15684720. Brown AJ, Goldsworthy SM, Barnes AA, et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate
Moxetumomab pasudotox (1,150 words) [view diff] exact match in snippet view article find links to article
that CAT-8015 had started Phase III clinical trials. On 5 December 2008, orphan designation (EU/3/08/592) was granted by the European Commission to Medimmune
Lintuzumab (505 words) [view diff] exact match in snippet view article find links to article
Administration and the European Medicines Agency had granted lintuzumab orphan drug status for treatment of AML and myelodysplastic syndromes. Seattle
Mogamulizumab (593 words) [view diff] no match in snippet view article find links to article
Mogamulizumab, sold under the brand name Poteligeo, is a humanized, afucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4). The U.S
Clarice Starling (2,042 words) [view diff] no match in snippet view article find links to article
Clarice M. Starling is a fictional character and protagonist of the novels The Silence of the Lambs (1988) and Hannibal (1999) by Thomas Harris. In the
Baxter International (3,437 words) [view diff] no match in snippet view article find links to article
Baxter International Inc. is an American multinational health care company with headquarters in Deerfield, Illinois. The company primarily focuses on products
Tacrolimus (3,757 words) [view diff] no match in snippet view article find links to article
Tacrolimus, sold under the brand names Protopic and Prograf among others, is an immunosuppressive drug. It is used after allogeneic organ transplant to
Harold Gray (1,134 words) [view diff] exact match in snippet view article find links to article
cartoonist, best known as the creator of the newspaper comic strip Little Orphan Annie. Harold Gray was born in Kankakee, Illinois on January 20, 1894, to
Rifapentine (895 words) [view diff] exact match in snippet view article find links to article
made from rifampicin.[medical citation needed] Rifapentine was granted orphan drug designation by the FDA in June 1995, and by the European Commission
Brentuximab vedotin (1,796 words) [view diff] no match in snippet view article find links to article
Brentuximab vedotin (INN, trade name Adcetris) is an antibody-drug conjugate medication used to treat relapsed or refractory Hodgkin lymphoma (HL) and
Johnson & Johnson (10,955 words) [view diff] no match in snippet view article find links to article
Johnson & Johnson is an American multinational corporation founded in 1886 that develops medical devices, pharmaceutical, and consumer packaged goods.
Moderna (5,003 words) [view diff] exact match in snippet view article find links to article
traditional high-margin chronic therapeutic areas with AstraZeneca and in orphan diseases with Alexion Pharmaceuticals. In 2014, Moderna moved to focus on
GPR3 (841 words) [view diff] exact match in snippet view article find links to article
Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase"
John Fawcett (director) (473 words) [view diff] exact match in snippet view article
director for the award-winning BBC America and Space sci-fi television series Orphan Black. Fawcett began his career making commercials before moving on to direct
GPCR neuropeptide receptor (258 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Clear Paddock Creek (155 words) [view diff] exact match in snippet view article find links to article
Clear Paddock Creek is a tributary of Orphan School Creek, which in turn, is a tributary of Prospect Creek, located in the City of Fairfield, NSW. It flows
Bristol Myers Squibb (4,709 words) [view diff] no match in snippet view article find links to article
Bristol Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City. Bristol Myers Squibb manufactures prescription pharmaceuticals
Oerba Dia Vanille (1,097 words) [view diff] exact match in snippet view article find links to article
she summons and defeats the Eidolon Hecatoncheir. After the defeat of Orphan, she and Fang transform into Ragnarok and form a crystal pillar to prevent
Panobinostat (1,158 words) [view diff] no match in snippet view article find links to article
Panobinostat (trade name Farydak /ˈfɛərədæk/ FAIR-ə-dak) is a drug by Novartis for the treatment of various cancers. It is a hydroxamic acid and acts as
Hefner (band) (1,085 words) [view diff] exact match in snippet view article
Hefner Soul - Too Pure - 1998 The Hefner Heart - Acuarela Discos - 1999 Orphan Songs - Everlasting Records - 1999 Revelations - Too Pure - 1999 The Hefner
Ranirestat (295 words) [view diff] exact match in snippet view article find links to article
neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin. It has been granted orphan drug status. The drug is to be used orally. A Canadian Phase III clinical
Starkiller (3,612 words) [view diff] no match in snippet view article find links to article
Starkiller, born Galen Marek and also known as The Apprentice, is the fictional protagonist of the Star Wars: The Force Unleashed video games and literature
Anakinra (881 words) [view diff] exact match in snippet view article find links to article
human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum. Anakinra is administered at home by subcutaneous injection. It
GPR20 (192 words) [view diff] exact match in snippet view article find links to article
Yokomizo T, Shimizu T, Nakamura M (May 2008). "Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins"
Jaume Collet-Serra (1,070 words) [view diff] exact match in snippet view article find links to article
soccer movie Goal II: Living the Dream (2007), the psychological horror Orphan (2009), the Liam Neeson action-thrillers Unknown (2011), Non-Stop (2014)
The Queen's Gambit (miniseries) (3,533 words) [view diff] exact match in snippet view article
Beginning mid-1950s and proceeding into the 1960s, the story is about an orphaned chess prodigy on her rise to becoming the world's greatest chess player
GPR77 (694 words) [view diff] exact match in snippet view article find links to article
1016/S0161-5890(00)00067-5. PMID 11090875. Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a
James Bond (literary character) (7,846 words) [view diff] exact match in snippet view article
his father's work as a Vickers armaments company representative. Bond is orphaned at the age of 11 when his parents are killed in a mountain climbing accident
Crizanlizumab (535 words) [view diff] exact match in snippet view article find links to article
crizanlizumab-tmca priority review, breakthrough therapy designation, and orphan drug designation. The FDA granted approval of Adakveo to Novartis. "Crizanlizumab
Neuropeptides B/W receptor 2 (454 words) [view diff] exact match in snippet view article find links to article
(2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32
Linsitinib (277 words) [view diff] exact match in snippet view article find links to article
proliferation and induces tumor cell apoptosis. Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012. Phase II clinical
GPR142 (218 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Lanadelumab (472 words) [view diff] no match in snippet view article find links to article
Lanadelumab (INN; trade name Takhzyro) is a human monoclonal antibody (class IgG1 kappa) that targets plasma kallikrein (pKal) in order to promote prevention
Natty Bumppo (1,317 words) [view diff] no match in snippet view article find links to article
Nathaniel "Natty" Bumppo is a fictional character and the protagonist of James Fenimore Cooper's pentalogy of novels known as the Leatherstocking Tales
Loncastuximab tesirine (479 words) [view diff] exact match in snippet view article find links to article
response and 14% partial response). Loncastuximab tesirine was granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the
Street children (6,158 words) [view diff] exact match in snippet view article find links to article
them more willing to force their children to the streets. For example, orphans are given financial benefits, but if they live in state-run facilities
Spectrum Pharmaceuticals (502 words) [view diff] no match in snippet view article find links to article
Spectrum Pharmaceuticals is an American biopharmaceutical company. The company is located in Irvine, California. Spectrum develops and markets drugs for
GPR139 (323 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Neuropeptide S receptor (1,696 words) [view diff] exact match in snippet view article find links to article
membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous
TLX3 (821 words) [view diff] exact match in snippet view article find links to article
is encoded by the TLX3 gene. RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members
Goku (9,590 words) [view diff] no match in snippet view article find links to article
Son Goku is a fictional character and main protagonist of the Dragon Ball manga series created by Akira Toriyama. He is based on Sun Wukong (Monkey King)
Ursodeoxycholic acid (1,870 words) [view diff] exact match in snippet view article find links to article
approved for use in the United States in December 1987, and was designated an orphan drug. Chenodeoxycholic acid—an epimer Hyodeoxycholic acid—an isomer "Ursodiol
SUCNR1 (300 words) [view diff] exact match in snippet view article find links to article
Tian H, Ling L (May 2004). "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors". Nature. 429 (6988): 188–93. doi:10.1038/nature02488
Amatuximab (927 words) [view diff] exact match in snippet view article find links to article
amatuximab orphan drug status for use in malignant pleural mesothelioma in November 2012, and the European Commission soon followed granting orphan drug status
Brain Powerd (2,343 words) [view diff] exact match in snippet view article find links to article
discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies"
Pharmaceutical industry (11,809 words) [view diff] exact match in snippet view article find links to article
benefit to society. There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases
Heidi (1937 film) (1,365 words) [view diff] exact match in snippet view article
story of the same name by Swiss author Johanna Spyri. The film is about an orphan named Heidi (Temple) who is taken from her grandfather (Jean Hersholt) to
Pyroglutamylated RFamide peptide receptor (603 words) [view diff] exact match in snippet view article find links to article
"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10
Olaparib (1,885 words) [view diff] no match in snippet view article find links to article
Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a
Maria Doyle Kennedy (2,665 words) [view diff] exact match in snippet view article find links to article
Tudors (2007–2010), Vera Bates in Downton Abbey (2011), Siobhán Sadler in Orphan Black (2013–2017), and Jocasta Cameron in Outlander (2018–present). Doyle
Vancouver Orphan Kitten Rescue Association (2,707 words) [view diff] exact match in snippet view article find links to article
The Vancouver Orphan Kitten Rescue Association (VOKRA) is a no kill, non-profit cat rescue organization in Vancouver, British Columbia, Canada, providing
Children's Aid Society (1,535 words) [view diff] exact match in snippet view article find links to article
adults. Brace was appalled by the thousands of abandoned, abused, and orphaned children living in the slums and on the streets of New York at the time
Sailor Jupiter (3,366 words) [view diff] no match in snippet view article find links to article
Makoto Kino (木野 まこと, Kino Makoto, renamed "Lita Kino" in some English adaptations), better known as Sailor Jupiter (セーラージュピター, Sērā Jupitā), is a fictional
Ivacaftor (3,058 words) [view diff] exact match in snippet view article find links to article
M. Orenstein; Carlos E. Milla (2 October 2013). "Viewpoint: Pricing for Orphan Drugs: Will the Market Bear What Society Cannot?". JAMA. 310 (13): 1343–1344
David Gustave (615 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
Raistlin Majere (7,144 words) [view diff] no match in snippet view article find links to article
Raistlin Majere is a fictional character from the Dragonlance series of books created by Margaret Weis and Tracy Hickman. Raistlin played an extensive
Vegeta (5,790 words) [view diff] no match in snippet view article find links to article
Vegeta (Japanese: ベジータ, Hepburn: Bejīta) (/vəˈdʒiːtə/ və-JEE-tə), also known as Prince Vegeta (ベジータ王子, Bejīta-ōji) or alternatively styled as Vegeta IV
James Frain (653 words) [view diff] exact match in snippet view article find links to article
The Tunnel (2013), Ferdinand Chevalier in the BBC/Space sci-fi thriller Orphan Black (2015–2017), Theo Galavan/Azrael in Fox's Gotham (2015–2016), and
Rickon Stark (1,840 words) [view diff] no match in snippet view article find links to article
Rickon Stark is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Acalabrutinib (1,049 words) [view diff] exact match in snippet view article find links to article
and was similarly designated as an orphan medicinal product by the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP) for treatment
4-Aminopyridine (1,823 words) [view diff] no match in snippet view article find links to article
4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric
GlaxoSmithKline (9,987 words) [view diff] no match in snippet view article find links to article
GlaxoSmithKline plc (GSK) is a British multinational pharmaceutical company headquartered in Brentford, England. Established in 2000, by a merger of Glaxo
Alec Trevelyan (1,143 words) [view diff] no match in snippet view article find links to article
Alec Trevelyan (006), also known as Janus, is a fictional character and the main antagonist in the 1995 James Bond film GoldenEye, the first film to feature
Natasha Romanoff (Marvel Cinematic Universe) (6,557 words) [view diff] no match in snippet view article
Natasha Romanoff is a fictional character portrayed by Scarlett Johansson in the Marvel Cinematic Universe (MCU) film franchise—based on the Marvel Comics
Special-purpose entity (1,292 words) [view diff] exact match in snippet view article find links to article
defeat the point of the securitization. Therefore, many SPEs are set up as 'orphan' companies with their shares settled on charitable trust and with professional
Scenic World (934 words) [view diff] exact match in snippet view article find links to article
Scenic World began building a roller coaster known as the Orphan Rocker, named after the nearby Orphan Rock. This is the first roller coaster to be completely
Samus Aran (5,275 words) [view diff] exact match in snippet view article find links to article
Ridley in an attack that killed her parents and destroyed the colony. The orphaned Samus was then found by a bird-like alien race known as the Chozo, who
Comic Strip Classics (143 words) [view diff] exact match in snippet view article find links to article
Goldberg’s Inventions Toonerville Folks Gasoline Alley Barney Google Little Orphan Annie Popeye Blondie Dick Tracy Alley Oop Nancy Flash Gordon Li'l Abner
Hepatocyte nuclear factor 4 alpha (2,119 words) [view diff] exact match in snippet view article find links to article
F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (Feb 2003). "The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction
Atezolizumab (3,195 words) [view diff] no match in snippet view article find links to article
Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC)
GPR32 (923 words) [view diff] exact match in snippet view article find links to article
initially identified and defined by molecular cloning in 1998 as coding for an orphan receptor, i.e. a protein with an amino acid sequence similar to known receptors
Alison Steadman (1,297 words) [view diff] exact match in snippet view article find links to article
include Pride and Prejudice (1995), Gavin & Stacey (2007–2010, 2019) and Orphan Black (2015–2016). Her other film appearances include A Private Function
Mikołaj Krzysztof "the Orphan" Radziwiłł (1,075 words) [view diff] exact match in snippet view article find links to article
Radvila Našlaitėlis) (2 Augustus 1549 – 28 February 1616) and nicknamed "the Orphan" (Lithuanian: Našlaitėlis, Polish: Sierotka), was a Polish–Lithuanian nobleman
COUP-TFI (1,468 words) [view diff] exact match in snippet view article find links to article
mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22
Comic strip (6,252 words) [view diff] exact match in snippet view article find links to article
Alley Oop (1932–present) Bringing Up Father (1913–2000; 87 years) Little Orphan Annie (1924–2010; 86 years) Most newspaper comic strips are syndicated;
Karlani (251 words) [view diff] exact match in snippet view article find links to article
The legend of Karlani in the folklore says: "In his infancy he became an orphan and after losing his family he alone survived and was adopted by the Ormur
Oerba Yun Fang (1,213 words) [view diff] no match in snippet view article find links to article
Oerba Yun Fang (ヲルバ=ユン・ファング, Woruba-Yun Fangu, Fang of the Yun clan from the village of Oerba) is a fictional character in the 2009 video game Final Fantasy
Little Orphan Annie (1932 film) (195 words) [view diff] exact match in snippet view article
Little Orphan Annie is a 1932 American pre-Code comedy film directed by John S. Robertson, and written by Wanda Tuchock and Tom McNamara. It is based on
Belantamab mafodotin (653 words) [view diff] exact match in snippet view article find links to article
(FDA) granted the application for belantamab mafodotin priority review, orphan drug designation, and breakthrough therapy designation. Belantamab mafodotin
Eribulin (1,932 words) [view diff] exact match in snippet view article find links to article
population, Eisai was able to file a New Drug Application (NDA) under the orphan and rare disease designation. On January 28, 2016, the FDA approved eribulin
Zenarestat (93 words) [view diff] no match in snippet view article find links to article
Zenarestat (FK-366; FR-74366) is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract, but its development
Acanthamoeba keratitis (2,777 words) [view diff] exact match in snippet view article find links to article
important to vision. Recently, AK has been recognized as an orphan disease and a funded project, orphan diseases Acanthamoeba keratitis (ODAK), has tested the
Spinocerebellar ataxia (2,745 words) [view diff] exact match in snippet view article find links to article
Retrieved 2019-08-01. "Search Orphan Drug Designations and Approvals". www.accessdata.fda.gov. Retrieved 2019-08-01. "Search Orphan Drug Designations and Approvals"
Gusperimus (757 words) [view diff] exact match in snippet view article find links to article
Bristol-Myers Squibb. Currently, it is manufactured and sponsored for use as an orphan drug and for clinical studies by the Japanese company Euro Nippon Kayaku
Alsatian Orphan (229 words) [view diff] exact match in snippet view article find links to article
The Alsatian Orphan / L'Orpheline Alsacienne is a sculpture made by the French artist Auguste Rodin (1840-1917). In the beginning of his career, Rodin
Belantamab mafodotin (653 words) [view diff] exact match in snippet view article find links to article
(FDA) granted the application for belantamab mafodotin priority review, orphan drug designation, and breakthrough therapy designation. Belantamab mafodotin
Zenarestat (93 words) [view diff] no match in snippet view article find links to article
Zenarestat (FK-366; FR-74366) is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract, but its development
GPR83 (322 words) [view diff] exact match in snippet view article find links to article
"Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83)". Cytogenet Cell Genet. 90 (1–2):
Satralizumab (1,300 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for satralizumab fast track and orphan drug designations. The FDA granted the approval of Enspryng to Genentech
Babacar (band) (259 words) [view diff] exact match in snippet view article
rock supergroup formed in England, featuring former members of Shelleyan Orphan, The Cure, and Presence. The group released one album in their brief existence
Gusperimus (757 words) [view diff] exact match in snippet view article find links to article
Bristol-Myers Squibb. Currently, it is manufactured and sponsored for use as an orphan drug and for clinical studies by the Japanese company Euro Nippon Kayaku
Cascadia subduction zone (3,807 words) [view diff] exact match in snippet view article find links to article
Since no earthquake had been observed to produce it, scholars dubbed it an "orphan tsunami." Translating the Japanese calendar, Satake found the incident had
Fidarestat (151 words) [view diff] no match in snippet view article find links to article
Fidarestat (SNK-860) is an aldose reductase inhibitor under investigation for treatment of diabetic neuropathy. Aldose reductase inhibitor for treatment
Portrayal of James Bond in film (8,297 words) [view diff] no match in snippet view article find links to article
Commander James Bond RN—code number 007—is a fictional character created by the British journalist and novelist Ian Fleming in 1952. The character appeared
Caffeine citrate (579 words) [view diff] no match in snippet view article find links to article
Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it
Gilteritinib (508 words) [view diff] exact match in snippet view article find links to article
mutation as detected by an FDA-approved test. Gilteritinib was granted orphan drug status by the U.S. FDA, the European Commission (EC) and the Japan
William Matthews (priest) (7,523 words) [view diff] exact match in snippet view article
and president of St. Vincent's Female Orphan Asylum and the co-founder and president of St. Joseph's Male Orphan Asylum. He played a significant role in
Garden of Eden (cellular automaton) (3,470 words) [view diff] exact match in snippet view article
a Garden of Eden if and only if it contains an orphan. For one-dimensional cellular automata, orphans and Gardens of Eden can be found by an efficient
Rydia (1,104 words) [view diff] no match in snippet view article find links to article
Rydia of Mist (ミストのリディア, Misuto no Ridia) is a fictional character in the Final Fantasy series. She appears in Final Fantasy IV as one of its protagonists
GPR63 (381 words) [view diff] exact match in snippet view article find links to article
1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056
Tarextumab (76 words) [view diff] exact match in snippet view article find links to article
as a possible treatment for cancer. In January 2015, the US FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and
BioMarin Pharmaceutical (1,649 words) [view diff] exact match in snippet view article find links to article
As of 2016, BioMarin has six products on the market, each of which is an orphan drug. Tetrahydrobiopterin (branded as Kuvan) (sapropterin dihydrochloride)
Fidaxomicin (1,142 words) [view diff] no match in snippet view article find links to article
Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins
Tiratricol (382 words) [view diff] exact match in snippet view article find links to article
resistance and adjuvant therapy of thyroid cancer. It is available as an orphan drug to be prescribed by registered specialists in Europe. Carvalho GA,
The Flash (season 5) (5,949 words) [view diff] case mismatch in snippet view article
Retrieved February 15, 2019. "TV REVIEW: THE FLASH S5 E16 - 'FAILURE IS AN ORPHAN'". Dynamic Forces. March 13, 2019. Retrieved April 19, 2019. "(#517) "Time
Christine Daaé (1,690 words) [view diff] no match in snippet view article find links to article
Christine Daaé is a fictional character and the female protagonist of Gaston Leroux's 1910 novel The Phantom of the Opera and of the various adaptations
Clofazimine (1,843 words) [view diff] exact match in snippet view article find links to article
Clarithromycin. However, in the United States, Clofazimine is considered and orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC
PSB-SB-487 (175 words) [view diff] exact match in snippet view article find links to article
PSB-SB-487 is a coumarin derivative which is an antagonist at the former orphan receptor GPR55. Unlike older GPR55 antagonists such as O-1918, PSB-SB-487
List of Marvel Comics characters: O (3,528 words) [view diff] no match in snippet view article find links to article
0–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Blackjack O'Hare is a fictional anthropomorphic hare in Marvel Comics. The character, created by
Jimmy Bennett (833 words) [view diff] exact match in snippet view article find links to article
Daddy Day Care, Hostage, The Amityville Horror, Poseidon, Evan Almighty, Orphan, Shorts, and as young James T. Kirk in the 2009 film Star Trek. He also
GPR17 (1,794 words) [view diff] exact match in snippet view article find links to article
functions of this receptor are disputed. Initially discovered in 1998 as an Orphan receptor, i.e. a receptor whose activating ligand(s) and function were unknown
Defibrotide (1,247 words) [view diff] exact match in snippet view article find links to article
FDA granted the application for defibrotide priority review status and orphan drug designation. The FDA granted approval of Defitelio to Jazz Pharmaceuticals
Ravulizumab (565 words) [view diff] no match in snippet view article find links to article
Ravulizumab, sold under the brand name Ultomiris, is a humanized monoclonal antibody complement inhibitor medication designed for the treatment of paroxysmal
Faris Scherwiz (1,567 words) [view diff] no match in snippet view article find links to article
Faris Scherwiz is a fictional character in the Final Fantasy series. She first appears in Final Fantasy V as an early antagonist and later one of its protagonists
Prokineticin receptor 1 (511 words) [view diff] exact match in snippet view article find links to article
and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402
Bayer (10,166 words) [view diff] no match in snippet view article find links to article
Bayer AG (/ˈbeɪ.ər, ˈbaɪ.ər/; German: [ˈbaɪɐ]) is a German multinational pharmaceutical and life sciences company and one of the largest pharmaceutical
Second Doctor (2,509 words) [view diff] exact match in snippet view article find links to article
returned home, the Doctor and Jamie would at first be joined by the Victorian orphan Victoria Waterfield (Deborah Watling) and then by the 21st century astrophysicist
Jason Voorhees (12,246 words) [view diff] exact match in snippet view article find links to article
Jason, Ari Lehman, who had received a part in Sean Cunningham's Manny's Orphans, arrived to read for the character of Jack. Before he could get started
Methoxsalen (651 words) [view diff] no match in snippet view article find links to article
Methoxsalen (also called xanthotoxin), sold under the brand name Oxsoralen among others, is a drug used to treat psoriasis, eczema, vitiligo, and some
Squall Leonhart (4,325 words) [view diff] exact match in snippet view article find links to article
in an orphanage with the other playable characters, except Rinoa. The orphans were cared for by Edea; although Squall remembers little about his past
Inuyasha (character) (1,873 words) [view diff] no match in snippet view article
Inuyasha (Japanese: 犬夜叉) is a fictional character and the titular protagonist of Rumiko Takahashi's manga series InuYasha and its anime adaptation. Inuyasha
GPR116 (443 words) [view diff] exact match in snippet view article find links to article
(May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10
Anaphylatoxin receptors (71 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Yun and Yang (1,426 words) [view diff] no match in snippet view article find links to article
Yun (ユン) and Yang (ヤン, Yan) are a pair of fictional characters appearing in the Street Fighter fighting game series. The characters are twin brothers known
Nimotuzumab (803 words) [view diff] exact match in snippet view article find links to article
Immunology, Havana, Cuba) is a humanized monoclonal antibody that as of 2014 had orphan status in the US and EU for glioma, and marketing approval in India, China
Renly Baratheon (1,100 words) [view diff] no match in snippet view article find links to article
Renly Baratheon is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
GPR45 (365 words) [view diff] exact match in snippet view article find links to article
DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
GPR39 (572 words) [view diff] exact match in snippet view article find links to article
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39". Biochem. Biophys. Res. Commun. 351 (1):
Laurie Strode (3,002 words) [view diff] no match in snippet view article find links to article
Laurie Strode is a fictional character and a main protagonist in the Halloween franchise, appearing in seven of the films in the series, soon to be nine
Adhesion G protein-coupled receptor (3,385 words) [view diff] exact match in snippet view article find links to article
adhesion GPCRs. A majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors . Adhesion GPCRs get their
Gendry (2,266 words) [view diff] exact match in snippet view article find links to article
proudly made for himself, which earned him the nickname "Bull" by fellow orphan boy Lommy Greenhands. Gendry is not a point of view character in the novels
Neuropeptide FF receptor 2 (540 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Sarepta Therapeutics (1,074 words) [view diff] no match in snippet view article find links to article
Sarepta Therapeutics, Inc. (NASDAQ: SRPT) is a medical research and drug development company with corporate offices and research facilities in Cambridge
Tomorrow (Annie) (1,108 words) [view diff] exact match in snippet view article
Charnin and Thomas Meehan began working on a musical based on the Little Orphan Annie comic strips, Annie. Strouse contributed a reworked version of "Replay"
Tree-kangaroo (2,013 words) [view diff] exact match in snippet view article find links to article
days long and weaning occurs 87–240 days later. At the Adelaide Zoo, an orphaned tree-kangaroo joey was transferred to the pouch of a yellow-footed rock-wallaby
Tomorrow (Annie) (1,108 words) [view diff] exact match in snippet view article
Charnin and Thomas Meehan began working on a musical based on the Little Orphan Annie comic strips, Annie. Strouse contributed a reworked version of "Replay"
Yun and Yang (1,426 words) [view diff] no match in snippet view article find links to article
Yun (ユン) and Yang (ヤン, Yan) are a pair of fictional characters appearing in the Street Fighter fighting game series. The characters are twin brothers known
GPR45 (365 words) [view diff] exact match in snippet view article find links to article
DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
Neuropeptide FF receptor 2 (540 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
GPR39 (572 words) [view diff] exact match in snippet view article find links to article
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39". Biochem. Biophys. Res. Commun. 351 (1):
Gendry (2,266 words) [view diff] exact match in snippet view article find links to article
proudly made for himself, which earned him the nickname "Bull" by fellow orphan boy Lommy Greenhands. Gendry is not a point of view character in the novels
Orihime Inoue (2,579 words) [view diff] no match in snippet view article find links to article
Orihime Inoue (Japanese: 井上 織姫, Hepburn: Inoue Orihime) is a fictional character and in the Bleach manga series and its adaptations created by Tite Kubo
Adhesion G protein-coupled receptor (3,385 words) [view diff] exact match in snippet view article find links to article
adhesion GPCRs. A majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors . Adhesion GPCRs get their
Laurie Strode (3,002 words) [view diff] no match in snippet view article find links to article
Laurie Strode is a fictional character and a main protagonist in the Halloween franchise, appearing in seven of the films in the series, soon to be nine
Lumiliximab (275 words) [view diff] exact match in snippet view article find links to article
antibody that targets CD23. It acts as an immunomodulator and was awarded orphan drug status and fast track designation by the FDA. It was investigated in
Canadian Screen Award for Best Dramatic Series (43 words) [view diff] exact match in snippet view article find links to article
Arctic Air Bomb Girls Continuum King 2013 Orphan Black Blackstone Bomb Girls Flashpoint Motive 2014 Orphan Black 19-2 Continuum Motive Remedy 2015 19-2
Ibrutinib (2,476 words) [view diff] no match in snippet view article find links to article
Ibrutinib, sold under the brand name Imbruvica among others, is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK)
Clubber Lang (711 words) [view diff] no match in snippet view article find links to article
James "Clubber" Lang is a fictional character created by Sylvester Stallone for the film Rocky III, which was released in 1982. Lang serves as the main
Bagheera (2,126 words) [view diff] no match in snippet view article find links to article
Bagheera is a fictional character in Rudyard Kipling's Mowgli stories in The Jungle Book (coll. 1894) and The Second Jungle Book (coll. 1895). He is a
Snak (725 words) [view diff] no match in snippet view article find links to article
Snak (Danish for "chat") is a shareware Internet Relay Chat (IRC) client written by Kent Sorensen for the Macintosh platform. Snak is distributed as shareware
GPR34 (645 words) [view diff] exact match in snippet view article find links to article
Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
Aerith Gainsborough (4,593 words) [view diff] no match in snippet view article find links to article
Aerith Gainsborough (Japanese: エアリス・ゲインズブール, Hepburn: Earisu Geinzubūru), transliterated as Aeris Gainsborough in the English releases of Final Fantasy
Arthur Morgan (Red Dead) (2,328 words) [view diff] no match in snippet view article
Arthur Morgan is a fictional character and the playable protagonist of the 2018 video game Red Dead Redemption 2. A high-ranking member of the Van der
Buprenorphine/naloxone (3,226 words) [view diff] no match in snippet view article find links to article
Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone
Arya Stark (4,764 words) [view diff] no match in snippet view article find links to article
Arya Stark is a fictional character in American author George R. R. Martin's A Song of Ice and Fire epic fantasy novel series. She is a prominent point-of-view
Little Annie Rooney (1,035 words) [view diff] exact match in snippet view article find links to article
Little Annie Rooney is a comic strip about a young orphaned girl who traveled about with her dog, Zero. King Features Syndicate launched the strip on January
Cobimetinib (700 words) [view diff] exact match in snippet view article find links to article
vomiting, rash, photosensitivity, and pyrexia. Cobimetinib was awarded orphan drug status by the FDA for malignant melanoma with BRAFV600 mutation in
Hebrew Orphan Asylum (Baltimore, Maryland) (756 words) [view diff] exact match in snippet view article
The Hebrew Orphan Asylum is an historic institutional orphanage and former hospital building located in the Mosher neighborhood of Baltimore, Maryland
John Watts (New York politician) (1,219 words) [view diff] exact match in snippet view article
New York from 1802 to 1807. In 1831, Watts organized the Leake and Watts Orphan Asylum after his friend (who was also his sister Margaret's brother-in-law)
TinEye (1,144 words) [view diff] exact match in snippet view article find links to article
looking to make use of imagery under orphan works to find the copyright holders of that imagery. Being that orphan works can be defined as "copyrighted
ACKR3 (1,073 words) [view diff] exact match in snippet view article find links to article
receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the
Leukotriene B4 receptor (24 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Genzyme (1,927 words) [view diff] exact match in snippet view article find links to article
world’s population. Drugs used to treat such conditions are considered to be orphan drugs. Ceredase was the first effective treatment for Gaucher's disease
Paddington Bear (6,234 words) [view diff] exact match in snippet view article find links to article
information about his past. For instance, one story reveals that Paddington was orphaned in an earthquake, before being taken in and raised by his Aunt Lucy. There
ROR1 (1,071 words) [view diff] exact match in snippet view article find links to article
by the ROR1 gene. ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
Pomalidomide (974 words) [view diff] no match in snippet view article find links to article
Pomalidomide (INN; marketed as Pomalyst in the US and Imnovid in the European Union and Russia) is a derivative of thalidomide marketed by Celgene. It
Rain (Mortal Kombat) (2,714 words) [view diff] exact match in snippet view article
mention of his father or siblings, instead of describing him as having been orphaned at a young age by Kahn's conquest of Edenia and raised under the protection
Warrior Nun (TV series) (1,480 words) [view diff] exact match in snippet view article
Portuguese actress Alba Baptista in the role of Ava Silva, a quadriplegic orphan who discovers she now has supernatural powers which force her to join an
Fena: Pirate Princess (246 words) [view diff] exact match in snippet view article find links to article
Princess is a 12 episode original anime series that tells the tale of a young orphan girl, Fena Houtman. Fena has been raised on an Island where there is no
List of My-HiME characters (8,300 words) [view diff] exact match in snippet view article find links to article
attack by an Orphan. Mai materializes her Elements for the first time and also acquires her Child, Kagutsuchi, which she uses to defeat the Orphan. In the
Yuna (Final Fantasy) (4,100 words) [view diff] no match in snippet view article
Yuna (ユウナ, Yūna) is a fictional character from Square Enix's Final Fantasy series. She was introduced as the female protagonist, and one of the main playable
Bevacizumab (6,390 words) [view diff] no match in snippet view article find links to article
Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer it is
John Marston (Red Dead) (2,534 words) [view diff] no match in snippet view article
John Marston is a fictional character in the Red Dead video game series by Rockstar Games. He is the playable protagonist of the 2010 video game Red Dead
Beechholme (266 words) [view diff] no match in snippet view article find links to article
Beechholme was a children's home in Fir Tree Road, Banstead, Surrey. It was founded in 1879 as a Residential School for poor children from the slums of
Blue Sky Black Death (1,844 words) [view diff] exact match in snippet view article find links to article
started producing exclusively around 2000. Kingston, working under the name Orphan, began his solo producing career collaborating with rapper Noah23 and the
Terra Branford (2,779 words) [view diff] exact match in snippet view article find links to article
post-apocalyptic second half, Terra is found no longer wishing to fight. For the orphans of the town of Mobliz, she has become a mother figure. She fails to stop
Histamine receptor (203 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Nami (One Piece) (2,070 words) [view diff] no match in snippet view article
Nami (Japanese: ナミ, Japanese: [na̠mʲi]) is a fictional character in the One Piece franchise created by Eiichiro Oda. She is based on Ann and Silk, two
Sodium phenylbutyrate (1,642 words) [view diff] exact match in snippet view article find links to article
excretion of excess nitrogen. It is an orphan drug, marketed by Ucyclyd Pharma under the trade name Buphenyl, by Swedish Orphan International (Sweden) as Ammonaps
Gallium scan (2,887 words) [view diff] no match in snippet view article find links to article
A gallium scan is a type of nuclear medicine test that uses either a gallium-67 (67Ga) or gallium-68 (68Ga) radiopharmaceutical to obtain images of a specific
National Cartoonists Society (3,955 words) [view diff] exact match in snippet view article find links to article
both The Orphan Works Act of 2008 and the Shawn Bentley Orphan Works Act of 2008. Known collectively as "Artists United Against the U.S. Orphan Works Acts"
Veltuzumab (277 words) [view diff] exact match in snippet view article find links to article
was originally known as IMMU-106. In August 2015 the US FDA granted it orphan drug status for immune thrombocytopenia (ITP). A phase II trial is planned
Lucina (Fire Emblem) (1,747 words) [view diff] no match in snippet view article
Lucina (Japanese: ルキナ, Hepburn: Rukina) is a fictional character and one of the protagonists from Intelligent Systems's 2012 role-playing video game Fire
Quincy, M.E. (2,155 words) [view diff] exact match in snippet view article find links to article
hazardous waste, the proliferation of handguns, autism, Tourette's syndrome, orphan drugs and anorexia among others. Quincy, M.E., was one of the first dramatic
Bombesin receptor (62 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Eli Lilly and Company (9,782 words) [view diff] no match in snippet view article find links to article
Eli Lilly and Company is an American pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold
Molly Ringwald (2,706 words) [view diff] exact match in snippet view article find links to article
The Facts of Life (1979–80) after a casting director saw her playing an orphan in a stage production of the musical Annie. She and several other members
Formyl peptide receptor 3 (2,228 words) [view diff] exact match in snippet view article find links to article
receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10
The Royal Alexandra and Albert School (757 words) [view diff] exact match in snippet view article find links to article
Royal Alexandra School, which was founded in 1758, and The Royal Albert orphan School, which was founded in 1864 as a national memorial to Prince Albert
Fox McCloud (3,902 words) [view diff] no match in snippet view article find links to article
Fox McCloud is a video game character and the chief protagonist of Nintendo's Star Fox series. He is an anthropomorphic fox created and designed by Shigeru
Super Jrs. (844 words) [view diff] exact match in snippet view article find links to article
Hawkman, Aquaman and, later, Supergirl. In the Holiday Special, they are orphan youngsters from the Miss Piffle's Nursery School, transformed by the fairy
Sunday comics (2,210 words) [view diff] exact match in snippet view article find links to article
comic strips appear both daily and Sunday, in some cases, as with Little Orphan Annie, telling the same story daily and Sunday, in other cases, as with
Stolen Generations (10,155 words) [view diff] no match in snippet view article find links to article
The Stolen Generations (also known as Stolen Children) were the children of Australian Aboriginal and Torres Strait Islander descent who were removed from
Camille Montes (501 words) [view diff] no match in snippet view article find links to article
Camille Montes Rivero is a fictional character in the 2008 James Bond film Quantum of Solace portrayed by actress Olga Kurylenko. Camille is a Bolivian
Fenobam (835 words) [view diff] no match in snippet view article find links to article
Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular
Rima (1,234 words) [view diff] no match in snippet view article find links to article
Rima, also known as Rima the Jungle Girl, is the fictional heroine of W. H. Hudson's 1904 novel Green Mansions: A Romance of the Tropical Forest. In it
GPR33 (146 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Carl Johnson (Grand Theft Auto) (2,610 words) [view diff] no match in snippet view article
Carl "CJ" Johnson is a fictional character and the playable protagonist of the 2004 video game Grand Theft Auto: San Andreas, the fifth main installment
Iratumumab (77 words) [view diff] exact match in snippet view article find links to article
Medarex, which was later acquired by Bristol-Myers Squibb. The FDA granted orphan drug designation for Hodgkin's lymphoma in 2004. In 2009, development was
Bruce Wayne (Dark Knight trilogy) (5,490 words) [view diff] exact match in snippet view article
deduced his secret identity as Batman and can relate to him; Blake is also an orphan and has learned to hide his anger. He asks Bruce to return as Batman. Against
Hydroxycarboxylic acid receptor 1 (512 words) [view diff] exact match in snippet view article find links to article
2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". The Journal of Biological Chemistry
Oprozomib (274 words) [view diff] exact match in snippet view article find links to article
against bortezomib-resistant multiple myeloma cells. Oprozomib was granted orphan drug status for the treatment of Waldenström's macroglobulinaemia and multiple
Neuropeptide FF receptor (785 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Baby Buggy Bunny (762 words) [view diff] exact match in snippet view article find links to article
ill-gotten gains down Bugs' rabbit hole, forcing him to don the disguise of an orphan baby to get it back. Baby-Face Finster (a.k.a. Ant Hill Harry), a 35-year-old
Ontuxizumab (159 words) [view diff] exact match in snippet view article find links to article
endosialin (TEM1 or CD248). Phase I trials are complete and the drug was granted orphan drug status by the FDA for sarcoma. It is currently in phase II trials for
Jane Eyre (character) (2,156 words) [view diff] exact match in snippet view article
Victorian society. Thus, the plot outlines Jane's infancy and childhood as an orphan, her employment first as a teacher and then as a governess, and her romantic
Lorvotuzumab mertansine (169 words) [view diff] exact match in snippet view article find links to article
cancers (e.g. small-cell lung cancer, ovarian cancer). It has been granted Orphan drug status for Merkel cell carcinoma. It has reported encouraging Phase
Laawaris (1981 film) (846 words) [view diff] exact match in snippet view article
Laawaris (transl. Orphan or Scoundrel ) is an 1981 Indian drama film directed by Prakash Mehra. The film became known for its song "Mere Angene Mein Tumhara
21st Genie Awards (65 words) [view diff] exact match in snippet view article find links to article
Maelström Alain DesRochers, The Bottle (La Bouteille) Robert Favreau, The Orphan Muses (Les Muses orphelines) Robert Lepage, Possible Worlds Gary Burns,
Azumi (1,108 words) [view diff] no match in snippet view article find links to article
Azumi (Japanese: あずみ) is a manga series created by Yū Koyama in 1994. Its story concerns the title character, a young woman brought up as part of a team
Time's Orphan (929 words) [view diff] exact match in snippet view article find links to article
"Time's Orphan" is the 148th episode of the syndicated American science fiction television series Star Trek: Deep Space Nine, the 24th episode of the sixth
BD Wong (1,577 words) [view diff] exact match in snippet view article find links to article
starred in the U.S. premiere of James Fenton's acclaimed adaptation of The Orphan of Zhao, a classic Chinese legend that has its roots in the fourth century
P2Y receptor (1,870 words) [view diff] exact match in snippet view article find links to article
P2RY6 P2RY6 Gq/11 UDP P2RY8 P2RY8 orphan receptor P2RY9 / LPAR4 / GPR23 LPAR4 Lysophosphatidic acid P2RY10 P2RY10 orphan receptor P2RY11 P2RY11 Gq/11 and
Satellite Award for Best Actress – Television Series Drama (24 words) [view diff] exact match in snippet view article find links to article
Ellie Miller Vera Farmiga Bates Motel Norma Louise Bates Tatiana Maslany Orphan Black Various Characters Anne Reid Last Tango in Halifax Celia Dawson Keri
LGBT adoption (7,056 words) [view diff] no match in snippet view article find links to article
LGBT adoption is the adoption of children by lesbian, gay, bisexual, transgender (LGBT+) people. This may be in the form of a joint adoption by a same-sex
Finisterre–Huon languages (585 words) [view diff] exact match in snippet view article find links to article
bɔruŋ ‘flame’ < *mbalaŋ ‘flame’ butoŋ ‘fingernail’ < *mb(i,u)t(i,u)C bekɔ ‘orphan’ < *mbVŋga(-masi) masiŋ ‘widow’ < *masi sambɔŋ ‘sky’ < *sambV ‘cloud’ tofeʔ
Ajulemic acid (338 words) [view diff] exact match in snippet view article find links to article
Corbus Pharmaceuticals (formerly JB Therapeutics) for the treatment of orphan chronic life-threatening inflammatory diseases.[citation needed] Burstein
Claude Frollo (2,472 words) [view diff] exact match in snippet view article find links to article
Dame. Dom Claude Frollo is a pious and highly knowledgeable man who was orphaned along with his younger brother Jehan when their parents died of the plague
Miglustat (1,130 words) [view diff] no match in snippet view article find links to article
Miglustat, sold under the brand name Zavesca, is a medication used to treat type I Gaucher disease (GD1). It was developed by Oxford GlycoSciences and
Belinostat (344 words) [view diff] exact match in snippet view article find links to article
trial for T-cell lymphoma were encouraging. Belinostat has been granted orphan drug and fast track designation by the FDA, and was approved in the US for
First Doctor (3,340 words) [view diff] exact match in snippet view article find links to article
(Jacqueline Hill). In later episodes, he travelled alongside 25th-century orphan Vicki (Maureen O'Brien), space pilot Steven (Peter Purves), Trojan handmaiden
Joseph Soul (620 words) [view diff] exact match in snippet view article find links to article
years to assist the plight of orphaned children in London and in support of the abolition of slavery. He worked at the Orphan Working School in Hampstead
Link (The Legend of Zelda) (9,059 words) [view diff] no match in snippet view article
Link is a fictional character and the main protagonist of Nintendo's video game series The Legend of Zelda. He appears in several incarnations over the
James and the Giant Peach (1,667 words) [view diff] exact match in snippet view article find links to article
name in 1996, and a musical in 2010. The plot centres on a young English orphan boy who enters a gigantic, magical peach, and has a wild and surreal cross-world
Maniac Magee (2,345 words) [view diff] exact match in snippet view article find links to article
Exploring themes of racism and inequality, it follows the story of an orphan boy looking for a home in the fictional town of Two Mills. Two Mills is
Final Fantasy XIII (10,916 words) [view diff] exact match in snippet view article find links to article
beast Ragnarok and slay the sleeping fal'Cie Orphan, who keeps Cocoon afloat above Pulse. Slaying Orphan will result in the destruction of Cocoon. The
GPR141 (178 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
GPR21 (177 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Pritumumab (248 words) [view diff] exact match in snippet view article find links to article
It is in clinical trials for the treatment of glioma. The FDA granted orphan drug designation in 2015. The target of Pritumumab, cell surface vimentin
Cholic acid (783 words) [view diff] no match in snippet view article find links to article
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic
Anastasia (1997 film) (4,946 words) [view diff] exact match in snippet view article
her family. Its basic plot centers around an eighteen-year-old amnesiac orphan named Anya who, in hopes of finding some trace of her family, sides with