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searching for Orphan 532 found (106862 total)

alternate case: orphan

Orphan Black (8,050 words) [view diff] exact match in snippet view article find links to article

Orphan Black is a Canadian science fiction thriller television series created by screenwriter Graeme Manson and director John Fawcett, starring Tatiana
Tatiana Maslany (3,419 words) [view diff] exact match in snippet view article find links to article
playing multiple characters in the science fiction thriller television series Orphan Black (2013–2017), which won her a Primetime Emmy Award (2016), a TCA Award
Rogue planet (2,992 words) [view diff] exact match in snippet view article find links to article
rogue planet (also termed an interstellar, nomad, free-floating, unbound, orphan, wandering, starless, or sunless planet) is a planetary-mass object that
AstraZeneca (6,063 words) [view diff] exact match in snippet view article find links to article
would partner with Orca Pharmaceuticals to develop retinoic acid-related orphan nuclear receptor gamma inhibitors for use in the treatment of a number of
Orphan drug (3,959 words) [view diff] exact match in snippet view article find links to article
An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without
Diageo (2,738 words) [view diff] no match in snippet view article find links to article
Diageo plc (/diˈædʒioʊ/) is a British multinational beverage alcohol company, with its headquarters in London, England. It operates in more than 180 countries
Rare disease (1,828 words) [view diff] exact match in snippet view article find links to article
affects a small percentage of the population. In some parts of the world, an orphan disease is a rare disease whose rarity means there is a lack of a market
Temple Riders (113 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
European Medicines Agency (2,469 words) [view diff] exact match in snippet view article find links to article
CHMP as described above. The Committee on Orphan Medicinal Products (COMP) administers the granting of orphan drug status since 2000. Companies intending
Annie (musical) (7,297 words) [view diff] exact match in snippet view article
Broadway musical based upon the popular Harold Gray comic strip Little Orphan Annie, with music by Charles Strouse, lyrics by Martin Charnin, and book
Acronym (13,956 words) [view diff] exact match in snippet view article find links to article
"K9" (kay-nine) for "canine". Pseudo-acronyms also frequently develop as "orphan initialisms"; an existing acronym is redefined as a non-acronymous name
RAR-related orphan receptor gamma (2,321 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is member of the
Orphan (2009 film) (2,077 words) [view diff] exact match in snippet view article
Orphan is a 2009 psychological horror film directed by Jaume Collet-Serra and written by David Leslie Johnson from a story by Alex Mace. The film stars
Little Orphan Annie (7,513 words) [view diff] exact match in snippet view article find links to article
Little Orphan Annie is a daily American comic strip created by Harold Gray and syndicated by the Tribune Media Services. The strip took its name from the
Cassandra Cain (6,028 words) [view diff] exact match in snippet view article find links to article
have assumed the role of Batgirl, and Cassandra Cain goes by the name of Orphan in DC Comics' current continuity. Cassandra's origin story present her as
RAR-related orphan receptor (1,110 words) [view diff] exact match in snippet view article find links to article
The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR
RAR-related orphan receptor beta (987 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans
Orphan receptor (727 words) [view diff] exact match in snippet view article find links to article
a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan". Conversely, the term orphan ligand refers to
Orphanet (1,070 words) [view diff] exact match in snippet view article find links to article
providing information about rare diseases as well as corresponding diagnosis, orphan drugs, clinical trials and expert networks The website is managed by a consortium
Nuclear receptor 4A3 (1,321 words) [view diff] exact match in snippet view article find links to article
(nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene
RAR-related orphan receptor alpha (2,659 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is
Orphan work (1,449 words) [view diff] exact match in snippet view article find links to article
An orphan work is a copyright-protected work for which rightsholders are positively indeterminate or uncontactable. Sometimes the names of the originators
Retinoic acid-inducible orphan G protein-coupled receptor (367 words) [view diff] exact match in snippet view article find links to article
The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression
Tom Sawyer (479 words) [view diff] no match in snippet view article find links to article
Thomas Sawyer (/ˈsɔːjər/) is the title character of the Mark Twain novel The Adventures of Tom Sawyer (1876). He appears in three other novels by Twain:
Lord Voldemort (7,952 words) [view diff] no match in snippet view article find links to article
Lord Voldemort (/ˈvoʊldəmɔːr/, /-mɔːrt/ in the films) is a sobriquet for Tom Marvolo Riddle, a fictional character and the main antagonist in J. K. Rowling's
Isabelle Fuhrman (1,246 words) [view diff] exact match in snippet view article find links to article
actress. She is best known for her roles as Esther in the 2009 horror film Orphan, and Clove in the 2012 dystopian adventure film The Hunger Games. Isabelle
X-Statix (2,280 words) [view diff] exact match in snippet view article find links to article
Allred. The storyline (which features the returns of the Anarchist, the Orphan, and U-Go Girl) parodies the manner in which creators in the industry handle
Johns Hopkins (4,202 words) [view diff] exact match in snippet view article find links to article
female orphans principally as domestic workers, and next as an "orthopedic convalescent" home and school for "colored crippled" children and orphans. The
Small heterodimer partner (1,773 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
Widows and orphans (891 words) [view diff] exact match in snippet view article find links to article
In typesetting, widows and orphans are lines at the beginning or end of a paragraph which are left dangling at the top or bottom of a page or column,
Orphan wells (1,643 words) [view diff] exact match in snippet view article find links to article
Orphan, Orphaned or abandoned wells are oil or gas wells that have been abandoned by fossil fuel extraction industries. These wells may have been deactivated
Testicular receptor 2 (925 words) [view diff] exact match in snippet view article find links to article
1016/S0006-291X(89)80028-2. PMID 2597158. Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate
Hydrocortisone (1,134 words) [view diff] no match in snippet view article find links to article
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital
Sodium oxybate (3,996 words) [view diff] exact match in snippet view article find links to article
approved for treating symptoms of narcolepsy in the European Union in 2005. Orphan Medical had developed it and was acquired by Jazz Pharmaceuticals in 2005
Rev-ErbA alpha (2,063 words) [view diff] exact match in snippet view article find links to article
these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite
Reed's School (2,169 words) [view diff] exact match in snippet view article find links to article
Kingdom. The foundation was established to provide relief to destitute orphans, including children whose fathers had died and whose mothers were unable
Orphan Girl at the Cemetery (331 words) [view diff] exact match in snippet view article find links to article
The Orphan Girl at the cemetery (also known as Young Orphan Girl in the Cemetery; French: Jeune orpheline au cimetière) (c. 1823 or 1824) is a painting
Budesonide (2,111 words) [view diff] no match in snippet view article find links to article
Budesonide (BUD), sold under the brand name Pulmicort among others, is a medication of the corticosteroid type. It is available as an inhaler, nebulization
Depatuxizumab mafodotin (259 words) [view diff] exact match in snippet view article find links to article
Depatux-M after late-stage failure in newly diagnosed glioblastoma. In 2014, Orphan Drug Status was granted by the FDA for glioblastoma multiforme. It is in
Oliver Twist (6,030 words) [view diff] exact match in snippet view article find links to article
three-volume book in 1838, before the serialisation ended. The story centres on orphan Oliver Twist, born in a workhouse and sold into apprenticeship with an undertaker
Solriamfetol (628 words) [view diff] exact match in snippet view article find links to article
adults with narcolepsy or obstructive sleep apnea (OSA). It was granted orphan drug designation. The U.S. Food and Drug Administration (FDA) approved solriamfetol
Tetrabenazine (564 words) [view diff] no match in snippet view article find links to article
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others
Amgen (2,433 words) [view diff] exact match in snippet view article find links to article
Swedish Orphan Biovitrum, in December 2008) Kineret (anakinra) for rheumatoid arthritis, exclusively licensed to Biovitrium, now Swedish Orphan Biovitrum
Amifampridine (3,094 words) [view diff] exact match in snippet view article find links to article
Amifampridine phosphate has orphan drug status in the EU for Lambert–Eaton myasthenic syndrome and Catalyst holds both an orphan designation and a breakthrough
Midway University (1,624 words) [view diff] exact match in snippet view article find links to article
working adults. Midway University originally opened as the Kentucky Female Orphan School on October 3, 1849, with one teacher and sixteen female students
Class C GPCR (251 words) [view diff] exact match in snippet view article find links to article
(GRM5) mGluR6 (GRM6) mGluR7 (GRM7) mGluR8 (GRM8) Retinoic acid-inducible orphan G protein-coupled receptors (RAIG) RAIG1 (GPRC5A) RAIG2 (GPRC5B) RAIG3 (GPRC5C)
The Orphan Master's Son (1,050 words) [view diff] exact match in snippet view article find links to article
The Orphan Master's Son is a 2012 novel by American author Adam Johnson. It deals with intertwined themes of propaganda, identity, and state power in North
Itachi Uchiha (3,150 words) [view diff] no match in snippet view article find links to article
Itachi Uchiha (Japanese: うちは イタチ, Hepburn: Uchiha Itachi) is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto. Itachi
Ambrisentan (555 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) and the European Medicines Agency (EMA), and designated an orphan drug, for the treatment of pulmonary hypertension. Ambrisentan is indicated
Nationalism and Ethnic Conflict (243 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
Testicular receptor 4 (1,135 words) [view diff] exact match in snippet view article find links to article
Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings
Tocilizumab (3,231 words) [view diff] exact match in snippet view article find links to article
older. In 2011 the US FDA approved tocilizumab for the treatment of the orphan disease, active systemic juvenile idiopathic arthritis (SJIA), a rare and
Estrogen-related receptor (1,169 words) [view diff] exact match in snippet view article find links to article
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of
Sotalol (1,504 words) [view diff] no match in snippet view article find links to article
Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. It is only recommended in those
Colchicine (4,954 words) [view diff] exact match in snippet view article find links to article
for Colcrys in the treatment of familial Mediterranean fever, under the Orphan Drug Law. URL Pharma then raised the price per tablet from $0.09 to $4.85
Gord the Rogue (2,138 words) [view diff] exact match in snippet view article find links to article
novel, Dance of Demons. The series of novels follows the progress of the orphan beggar Gord, from his lowly youth to his ascension as an avatar of Balance
Huckleberry Finn (1,534 words) [view diff] no match in snippet view article find links to article
Huckleberry "Huck" Finn is a fictional character created by Mark Twain who first appeared in the book The Adventures of Tom Sawyer (1876) and is the protagonist
Nuclear receptor 4A1 (2,326 words) [view diff] exact match in snippet view article find links to article
homodimer to NurRE. It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription
Orphan of the Pecos (697 words) [view diff] exact match in snippet view article find links to article
Orphan of the Pecos is a 1937 American Western film produced and directed by Sam Katzman and starring Tom Tyler, Jeanne Martel, Howard Bryant, and Forrest
Nuclear receptor (6,470 words) [view diff] exact match in snippet view article find links to article
target nuclear receptors. A number of nuclear receptors, referred to as orphan receptors, have no known (or at least generally agreed upon) endogenous
Methotrexate (2,738 words) [view diff] no match in snippet view article find links to article
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases
Emapalumab (665 words) [view diff] exact match in snippet view article find links to article
normal catabolism. The U.S. Food and Drug Administration (FDA) granted orphan drug designations in 2010 and 2020, and breakthrough therapy designation
Itraconazole (2,194 words) [view diff] exact match in snippet view article find links to article
"Itraconazole Orphan Drug Designation". U.S. Food and Drug Administration (FDA). 19 May 2016. Retrieved 15 May 2020. "Itraconazole Orphan Drug Designation"
Eculizumab (2,880 words) [view diff] exact match in snippet view article find links to article
tax incentives in the Orphan Drug Act of 1983. On average the cost per person for orphan drugs is "six times that of non-orphan drugs, a clear indication
COUP-TFII (1,544 words) [view diff] exact match in snippet view article find links to article
PMID 8530078. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development"
Liver receptor homolog-1 (1,327 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
Stiripentol (1,082 words) [view diff] exact match in snippet view article find links to article
December 2001, the European Medicines Agency (EMA) granted stiripentol orphan drug status (designation number EU/3/01/071) for the treatment of severe
Islamic adoptional jurisprudence (1,103 words) [view diff] exact match in snippet view article find links to article
child who is not one's genetic child is allowed and, in the case of an orphan, even encouraged. But, according to the Islamic view, the child does not
NAGly receptor (1,143 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous
Pramiracetam (398 words) [view diff] exact match in snippet view article find links to article
Phase II trials showed mixed results; it then began to develop it as an orphan drug as an adjunct to electroconvulsive therapy for major depressive disorder
Benralizumab (232 words) [view diff] exact match in snippet view article find links to article
treatment of severe eosinophilic asthma. It was granted designation as an orphan drug by the Food and Drug Administration for treatment of eosinophilic oesophagitis
Orphan Train (5,057 words) [view diff] exact match in snippet view article find links to article
The Orphan Train Movement was a supervised welfare program that transported children from crowded Eastern cities of the United States to foster homes located
AbbVie (1,913 words) [view diff] no match in snippet view article find links to article
AbbVie is an American publicly traded biopharmaceutical company founded in 2013. It originated as a spin-off of Abbott Laboratories. On October 19, 2011
Teduglutide (297 words) [view diff] exact match in snippet view article find links to article
restoring gastric emptying and secretion. In Europe it has been granted orphan drug status and is marketed under the brand Revestive by Nycomed. It was
Elizabeth Schuyler Hamilton (4,525 words) [view diff] exact match in snippet view article find links to article
is recognized as an early American philanthropist for her work with the Orphan Asylum Society. Elizabeth was born in Albany, New York, the second daughter
Avelumab (1,431 words) [view diff] exact match in snippet view article find links to article
targets the protein programmed death-ligand 1 (PD-L1). It has received orphan drug designation by the European Medicines Agency (EMA) for the treatment
Burosumab (757 words) [view diff] exact match in snippet view article find links to article
April 2018. The FDA approval fell under both the breakthrough therapy and orphan drug designations. It was approved for use in the European Union in February
Anagrelide (876 words) [view diff] exact match in snippet view article find links to article
Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (also
Superfund (5,077 words) [view diff] exact match in snippet view article find links to article
is allocable among PRPs in contribution based on comparative fault. An "orphan share" is the share of costs at a Superfund site that is attributable to
ELTD1 (446 words) [view diff] exact match in snippet view article find links to article
and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this
Rifaximin (1,841 words) [view diff] exact match in snippet view article find links to article
avoided in such cases.[citation needed] In the United States, rifaximin has orphan drug status for the treatment of hepatic encephalopathy. Although high-quality
Awful Orphan (634 words) [view diff] exact match in snippet view article find links to article
Awful Orphan is a 1949 Warner Bros. Merrie Melodies cartoon, directed by Chuck Jones and written by Michael Maltese. It is a sequel to the 1947 Looney
MRGPRG (141 words) [view diff] exact match in snippet view article find links to article
(GPR169) is a protein that in humans is encoded by the MRGPRG gene. MRGG is an orphan G-protein coupled receptor. GRCh38: Ensembl release 89: ENSG00000182170
SREB (130 words) [view diff] exact match in snippet view article find links to article
ligands have yet been identified for these receptors, they are classified as orphan receptors. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi
Estrogen-related receptor alpha (2,006 words) [view diff] exact match in snippet view article find links to article
that estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor. ERRα has wide tissue distribution but it is most highly
Glutamine (1,970 words) [view diff] exact match in snippet view article find links to article
extremities, back pain and chest pain. L-glutamine oral powder received orphan drug designation. The FDA granted the approval of Endari to Emmaus Medical
Olaratumab (896 words) [view diff] exact match in snippet view article find links to article
2010. In February 2015, the European Medicines Agency assigned olaratumab orphan drug status for the treatment of soft-tissue sarcoma. The European Commission
Bosentan (1,060 words) [view diff] no match in snippet view article find links to article
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery
Picornavirales (420 words) [view diff] exact match in snippet view article find links to article
picorna- is an acronym for poliovirus, insensitivity to ether, coxsackievirus, orphan virus, rhinovirus, and ribonucleic acid. Secondly, pico-, meaning extremely
Reoviridae (1,777 words) [view diff] exact match in snippet view article find links to article
tract. The name "reo-" is an acronym for "respiratory enteric orphan" viruses. The term "orphan virus" refers to the fact that some of these viruses have
Alvocidib (488 words) [view diff] exact match in snippet view article find links to article
(formerly Tolero Pharmaceuticals Inc.) announced that the FDA has granted orphan drug designation for Alvocidib, its cyclin-dependent kinase small molecule
Estrogen-related receptor gamma (1,269 words) [view diff] exact match in snippet view article find links to article
hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists
Bosentan (1,060 words) [view diff] no match in snippet view article find links to article
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery
Mitotane (743 words) [view diff] exact match in snippet view article find links to article
Mitotane has been produced by Bristol Myers Squibb but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in
Daratumumab (1,523 words) [view diff] exact match in snippet view article find links to article
breakthrough therapy drug status in 2013, for multiple myeloma. It was awarded orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular
Little Orphan Airedale (228 words) [view diff] exact match in snippet view article find links to article
Little Orphan Airedale is a Warner Bros. Looney Tunes cartoon directed by Charles M. Jones and released on October 4, 1947. Its major significance is its
GPR148 (300 words) [view diff] exact match in snippet view article find links to article
G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and
Durvalumab (736 words) [view diff] no match in snippet view article find links to article
Durvalumab (trade name Imfinzi) is an FDA-approved immunotherapy for cancer, developed by Medimmune/AstraZeneca. It is a human immunoglobulin G1 kappa
Often an Orphan (613 words) [view diff] exact match in snippet view article find links to article
Often an Orphan is a 1949 cartoon in the Merrie Melodies series. The cartoon was released on August 13, 1949 and stars Charlie Dog and Porky Pig. The cartoon
Rilonacept (409 words) [view diff] exact match in snippet view article find links to article
of human IgG1 that binds and neutralizes IL-1. Rilonacept was given an orphan drug designation by the U.S. Food and Drug Administration (FDA) and is used
Iduronidase (2,088 words) [view diff] exact match in snippet view article find links to article
enjoys orphan drug status in both the United States and the European Union, though in both its orphan drug exclusivity period has expired. (Orphan drug
GPR158 (389 words) [view diff] exact match in snippet view article find links to article
protein that in humans is encoded by the GPR158 gene. This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7
Polatuzumab vedotin (505 words) [view diff] exact match in snippet view article find links to article
vedotin-piiq breakthrough therapy designation, priority review designation, and orphan drug designation. The FDA granted the approval of Polivy to Genentech. Polatuzumab
Ibalizumab (653 words) [view diff] exact match in snippet view article find links to article
trial for s.c. and i.m. injection dosage forms (on-going). 2014: granted orphan drug designation for HIV MDR patients by U.S. FDA. 2015: granted breakthrough
Institut Catholique de Paris (1,262 words) [view diff] no match in snippet view article find links to article
The Institut Catholique de Paris (ICP), known in English as the Catholic University of Paris (and in Latin as Universitas catholica Parisiensis), is a
GPR12 (322 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR12 gene. The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene
Vesper Lynd (1,797 words) [view diff] no match in snippet view article find links to article
Vesper Lynd is a fictional character featured in Ian Fleming's 1953 James Bond novel Casino Royale. She was portrayed by Ursula Andress in the 1967 James
The Orphan of Zhao (2,659 words) [view diff] exact match in snippet view article find links to article
The Orphan of Zhao is a Chinese play from the Yuan era, attributed to the 13th-century dramatist Ji Junxiang (紀君祥). The play has as its full name The Great
Pfizer (11,022 words) [view diff] no match in snippet view article find links to article
Coordinates: 41°20′04″N 72°04′05″W / 41.3343429°N 72.06795°W / 41.3343429; -72.06795 Pfizer Inc. (/ˈfaɪzər/ FY-zər) is an American multinational pharmaceutical
Nami (One Piece) (2,076 words) [view diff] no match in snippet view article
Nami (Japanese: ナミ, Japanese: [na̠mʲi]) is a fictional character in the One Piece franchise created by Eiichiro Oda. She is based on Ann and Silk, two
List of Dove Medical Press academic journals (672 words) [view diff] exact match in snippet view article find links to article
Statistics† Open Access Rheumatology: Research and Reviews Open Access Surgery Orphan Drugs: Research and Reviews† Orthopedic Research and Reviews Pathology and
Larotrectinib (515 words) [view diff] exact match in snippet view article find links to article
licensed to Loxo Oncology in 2013. Larotrectinib was initially awarded orphan drug status in 2015, for soft tissue sarcoma, and breakthrough therapy designation
Sodium thiosulfate (1,381 words) [view diff] no match in snippet view article find links to article
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na2S2O3.xH2O. Typically it is available as the white or colorless pentahydrate
Eltrombopag (789 words) [view diff] exact match in snippet view article find links to article
collaboration between GlaxoSmithKline and Ligand Pharmaceuticals. Designated an orphan drug in the United States and European Union, it is being manufactured and
Duvelisib (718 words) [view diff] exact match in snippet view article find links to article
million payment for an FDA approval, and royalties. Duvelisib has received orphan drug designation in the United States for treatment of peripheral T-cell
2nd Canadian Screen Awards (243 words) [view diff] exact match in snippet view article find links to article
10 categories, while on the television side the science fiction series Orphan Black was nominated in 14 categories. The awards ceremony were hosted by
Annie (2014 film) (3,764 words) [view diff] exact match in snippet view article
musical of the same name (which in turn is based on the comic strip Little Orphan Annie by Harold Gray), the film stars Quvenzhané Wallis in the title role
GPRC5A (692 words) [view diff] exact match in snippet view article find links to article
dysregulated in many human cancers and in other diseases. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000013588 -
Han Solo (4,846 words) [view diff] exact match in snippet view article find links to article
Alden Ehrenreich. In the film, 19-year old Han is characterized to be an orphan on the planet Corellia. He and his lover, Qi'ra (Emilia Clarke), attempt
Retigabine (1,823 words) [view diff] exact match in snippet view article find links to article
PMC 2587091. PMID 18590620. Ben-Menachem E (2007). "Retigabine: Has the Orphan Found a Home?". Epilepsy Currents. 7 (6): 153–4. doi:10.1111/j.1535-7511
General German Protestant Orphans Home (147 words) [view diff] exact match in snippet view article find links to article
General German Protestant Orphans Home, also known as the Pleasant Run Children's Home , is a historic orphanage located in Indianapolis, Indiana. It
Track gauge conversion (792 words) [view diff] exact match in snippet view article find links to article
gauge conversion work, some stations and branch lines may become "gauge orphans". Trains can't operate to them until costly gauge conversion work is completed
Rasagiline (1,888 words) [view diff] no match in snippet view article find links to article
Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease
The Little Orphan (1,252 words) [view diff] exact match in snippet view article find links to article
The Little Orphan is a 1949 American one-reel animated cartoon and the 40th Tom and Jerry cartoon, released in theaters on April 30, 1949 by Metro-Goldwyn
Lombard, Illinois (2,023 words) [view diff] exact match in snippet view article find links to article
Gray's parents and the studio of Harold Gray, the originator of Little Orphan Annie cartoon strip. Harold Gray used the home's study to work on the Annie
Cabozantinib (1,462 words) [view diff] exact match in snippet view article find links to article
KIT), and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib was granted orphan drug status by the U.S. Food and Drug Administration (FDA) in November 2010
Rituximab (3,635 words) [view diff] no match in snippet view article find links to article
Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for
Teprotumumab (910 words) [view diff] exact match in snippet view article find links to article
Phase I for diabetic macular edema. It was granted Breakthrough Therapy, Orphan Drug Status and Fast Track designations by the FDA for Graves' ophthalmopathy
Umbralisib (768 words) [view diff] exact match in snippet view article find links to article
"Orphan Treatment of extranodal marginal zone lymphoma". U.S. Food and Drug Administration (FDA). 11 April 2019. Retrieved 5 February 2021. "Orphan Treatment
Abandonware (8,708 words) [view diff] exact match in snippet view article find links to article
abandonware is a software (or hardware) sub-case of the general concept of orphan works. Museums and various organizations dedicated to preserving this software
Mowgli (2,028 words) [view diff] no match in snippet view article find links to article
Mowgli /ˈmaʊɡli/ is a fictional character and the protagonist of Rudyard Kipling's The Jungle Book stories. He is a feral boy from the Pench area in Seoni
Evinacumab (367 words) [view diff] exact match in snippet view article find links to article
Food and Drug Administration (FDA) granted the application for evinacumab orphan drug, breakthrough therapy, and priority review designations. The FDA granted
Lenvatinib (887 words) [view diff] exact match in snippet view article find links to article
treating thyroid cancer patients started in March 2011. Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not
GPRC5C (647 words) [view diff] exact match in snippet view article find links to article
different isoforms have been found for this gene. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000170412 -
Moxetumomab pasudotox (1,242 words) [view diff] exact match in snippet view article find links to article
that CAT-8015 had started Phase III clinical trials. On 5 December 2008, orphan designation (EU/3/08/592) was granted by the European Commission to Medimmune
Neuropeptides B/W receptor 1 (1,058 words) [view diff] exact match in snippet view article find links to article
When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8, but at least three groups in
Johnson & Johnson (10,574 words) [view diff] no match in snippet view article find links to article
Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged
Gamora (Marvel Cinematic Universe) (2,570 words) [view diff] exact match in snippet view article
and her uncertainty over the film's commercial viability. Gamora is an orphan from an alien world who seeks redemption for her past crimes. She was trained
Break of gauge (6,170 words) [view diff] exact match in snippet view article find links to article
new gauge. These severed branches can be called gauge orphans. The opposite of a gauge orphan is a line of one gauge which reaches into the territory
GPR50 (768 words) [view diff] exact match in snippet view article find links to article
MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through
Thiotepa (612 words) [view diff] exact match in snippet view article find links to article
29, 2007, the European Medicines Agency (EMA) designated thiotepa as an orphan drug. On April 2, 2007, the United States FDA designated thiotepa as a conditioning
Quasimodo (2,982 words) [view diff] exact match in snippet view article find links to article
where he is found abandoned in Notre Dame (on the foundlings' bed, where orphans and unwanted children are left to public charity) on Quasimodo Sunday,
Romiplostim (562 words) [view diff] exact match in snippet view article find links to article
(immune) thrombocytopenic purpura (ITP). Romiplostim was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2003, as the chronic
Altretamine (524 words) [view diff] no match in snippet view article find links to article
Altretamine (trade name Hexalen) is an antineoplastic agent. It was approved by the U.S. FDA in 1990. It is indicated for use as a single agent in the
Lenvatinib (887 words) [view diff] exact match in snippet view article find links to article
treating thyroid cancer patients started in March 2011. Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not
Fasudil (961 words) [view diff] no match in snippet view article find links to article
Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which
The Devil's Hands Are Idle Playthings (1,286 words) [view diff] no match in snippet view article find links to article
"The Devil's Hands Are Idle Playthings" is the final episode in the fourth season of the American animated television series Futurama, and the finale of
Arylsulfatase B (1,817 words) [view diff] exact match in snippet view article find links to article
Galsulfase (N-acetylgalactosamine-4-sulfatase, recombinant human) was granted orphan drug designation by both the European Commission and the U.S. Food and Drug
Johnson & Johnson (10,574 words) [view diff] no match in snippet view article find links to article
Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged
Gamora (Marvel Cinematic Universe) (2,570 words) [view diff] exact match in snippet view article
and her uncertainty over the film's commercial viability. Gamora is an orphan from an alien world who seeks redemption for her past crimes. She was trained
GPRC5B (348 words) [view diff] exact match in snippet view article find links to article
acid on the G protein signal transduction cascade. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000167191 -
Genentech (3,004 words) [view diff] no match in snippet view article find links to article
Genentech, Inc., is an American biotechnology corporation which became a subsidiary of Roche in 2009. Genentech Research and Early Development operates
Entrectinib (2,033 words) [view diff] exact match in snippet view article find links to article
S., entrectinib has orphan drug designation and rare pediatric disease designation for the treatment of neuroblastoma and orphan drug designation for
Remdesivir (8,698 words) [view diff] exact match in snippet view article find links to article
as a result of the outbreak in the Czech Republic. On 17 February 2016, orphan designation (EU/3/16/1615) was granted by the European Commission to Gilead
Hannibal Lecter (6,171 words) [view diff] exact match in snippet view article find links to article
from his birth into an aristocratic family in Lithuania in 1933, to being orphaned, along with his beloved younger sister Mischa, in 1944 when a Nazi Stuka
Elesclomol (650 words) [view diff] exact match in snippet view article find links to article
GlaxoSmithKline as a chemotherapy adjuvant, and has received both fast track and orphan drug status from the U.S. Food and Drug Administration for the treatment
Vera Farmiga (7,312 words) [view diff] exact match in snippet view article find links to article
Primetime Emmy Award nomination. These roles, along with Joshua (2007) and Orphan (2009), established her as a scream queen. For her portrayal of a lawyer
Biogen (2,383 words) [view diff] exact match in snippet view article find links to article
hemophilia B 2014 1993 Also approved in Canada and Australia. Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization
Dacomitinib (266 words) [view diff] no match in snippet view article find links to article
Dacomitinib, sold under the brand name Vizimpro, is a medication for the treatment of non-small-cell lung carcinoma (NSCLC). It is a selective and irreversible
Gemtuzumab ozogamicin (1,157 words) [view diff] no match in snippet view article find links to article
Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute
Tipifarnib (673 words) [view diff] no match in snippet view article find links to article
Tipifarnib (INN, proposed trade name Zarnestra) is a farnesyltransferase inhibitor. Farnesyltransferase inhibitors block the activity of the farnesyltransferase
Terguride (502 words) [view diff] exact match in snippet view article find links to article
attenuation of disease progression. In May 2008, terguride was granted orphan drug status for the treatment of pulmonary arterial hypertension. In May
Venetoclax (2,319 words) [view diff] exact match in snippet view article find links to article
and accelerated approval along with breakthrough therapy designation and orphan drug designation. Venetoclax was approved for use in the European Union
Neuromedin U receptor 1 (440 words) [view diff] exact match in snippet view article find links to article
(Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and
Rev-ErbA beta (848 words) [view diff] exact match in snippet view article find links to article
Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (August 1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb"
Inuktitut Braille (759 words) [view diff] exact match in snippet view article find links to article
Commonwealth Braille and Talking Book Cooperative. The book ᐃᓕᐊᕐᔪᒃ ᓇᓄᕐᓗ The Orphan and the Polar Bear was the first (and perhaps only) work transliterated
Orphan School Creek (130 words) [view diff] exact match in snippet view article find links to article
33°52′58″S 151°10′34″E / 33.882663°S 151.176219°E / -33.882663; 151.176219 Orphan School Creek is a storm drain located in inner Sydney, New South Wales.
Cannabidiol (9,997 words) [view diff] exact match in snippet view article find links to article
Sjögren S, Hjorth S, Hermansson NO, Leonova J, et al. (December 2007). "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology
Vorinostat (1,091 words) [view diff] no match in snippet view article find links to article
Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds
Jaume Collet-Serra (1,095 words) [view diff] exact match in snippet view article find links to article
producer. He is known for directing the horror films House of Wax (2005), Orphan (2009), and The Shallows (2016), as well as the Liam Neeson-led thriller
Tom and Jerry filmography (803 words) [view diff] exact match in snippet view article find links to article
and beyond. Fifth cartoon where Tom and Jerry both lose. 40 The Little Orphan April 30, 1949 In this Thanksgiving short, Jerry and Nibbles dine on Thanksgiving
Fenfluramine (2,545 words) [view diff] exact match in snippet view article find links to article
"Fenfluramine Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 25 June 2020. "Fenfluramine Orphan Drug
Dasiglucagon (257 words) [view diff] exact match in snippet view article find links to article
for medical use in the United States in March 2021. It was designated an orphan drug in August 2017. Dasiglucagon is indicated for the treatment of severe
Ruxolitinib (1,142 words) [view diff] no match in snippet view article find links to article
Ruxolitinib, sold under the brand names Jakafi and Jakavi, is a medication for the treatment of intermediate or high-risk myelofibrosis, a type of myeloproliferative
Posaconazole (675 words) [view diff] no match in snippet view article find links to article
Posaconazole, sold under the brand names Noxafil and Posanol is a triazole antifungal medication. It was approved for medical use in the United States
Mogamulizumab (599 words) [view diff] no match in snippet view article find links to article
Mogamulizumab, sold under the brand name Poteligeo, is a humanized, afucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4). The U.S
Lyra Belacqua (1,472 words) [view diff] no match in snippet view article find links to article
Lyra Belacqua (/ˈlaɪrə bəˈlɑːkwə/), also known as Lyra Silvertongue, is the heroine of Philip Pullman's trilogy His Dark Materials. In His Dark Materials
Brigatinib (668 words) [view diff] exact match in snippet view article find links to article
application to the US FDA on August 29, 2016. In 2016, brigatinib was granted orphan drug status by the FDA for treatment of NSCLC. In 28 April 2017, it was
Ripretinib (1,025 words) [view diff] exact match in snippet view article find links to article
fast track designations, as well as breakthrough therapy designation and orphan drug designation. The FDA granted approval of Qinlock to Deciphera Pharmaceuticals
Wedge Antilles (1,896 words) [view diff] no match in snippet view article find links to article
Wedge Antilles is a fictional character in the Star Wars franchise. He is a supporting character portrayed by Denis Lawson in the original Star Wars trilogy
Orphan School Creek (Fairfield) (200 words) [view diff] exact match in snippet view article
Orphan School Creek is a tributary of Prospect Creek, located entirely within the City of Fairfield, NSW. It starts in Allambie Road Reserve, Bossley Park
Green Hornet (4,174 words) [view diff] exact match in snippet view article find links to article
Team Venture. It is also revealed that Blue Morpho was the father of the orphaned villain The Monarch, and he and Henchman 21 later take on the roles of
5th Canadian Screen Awards (493 words) [view diff] exact match in snippet view article find links to article
ceremony, the film It's Only the End of the World and the television series Orphan Black won the most awards in film and television categories, with six and
Vertex Pharmaceuticals (3,048 words) [view diff] exact match in snippet view article find links to article
Executive Chairman until April 2023. In 2012 ivacaftor was designated as an orphan drug, identifying cystic fibrosis as affecting fewer than 200,000 people
Belantamab mafodotin (707 words) [view diff] exact match in snippet view article find links to article
(FDA) granted the application for belantamab mafodotin priority review, orphan drug designation, and breakthrough therapy designation. Belantamab mafodotin
Matt Frewer (1,762 words) [view diff] exact match in snippet view article find links to article
icon Max Headroom and Doctor Leekie in the Canadian science fiction drama Orphan Black (2013–2017). Frewer's more recent performances include a portrayal
Tucatinib (1,401 words) [view diff] exact match in snippet view article find links to article
application for tucatinib priority review, breakthrough therapy, fast track, and orphan drug designations. The FDA granted approval of Tukysa to Seattle Genetics
Oswald Cobblepot (Batman Returns) (1,668 words) [view diff] no match in snippet view article
Oswald Cobblepot, commonly known as Penguin, is a fictional character who appears in Tim Burton's 1992 superhero film Batman Returns as the main antagonist
GPR75 (242 words) [view diff] exact match in snippet view article find links to article
proteins upon the binding of a ligand. GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study
Pemtumomab (157 words) [view diff] exact match in snippet view article find links to article
2009[update], it is undergoing Phase III clinical trials. It has been granted orphan drug status in Europe. Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas
Leonard Starr (1,195 words) [view diff] exact match in snippet view article find links to article
known for creating the newspaper comic strip On Stage and reviving Little Orphan Annie. Born October 28, 1925, in New York City, Starr graduated from Manhattan's
Anne with an E (5,253 words) [view diff] exact match in snippet view article find links to article
was created by Moira Walley-Beckett for CBC and stars Amybeth McNulty as orphan Anne Shirley, Geraldine James as Marilla Cuthbert, R. H. Thomson as Matthew
GPR182 (996 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. When this gene was first cloned, it was proposed
Wanda Maximoff (Marvel Cinematic Universe) (6,101 words) [view diff] no match in snippet view article
Wanda Maximoff is a character portrayed by Elizabeth Olsen in the Marvel Cinematic Universe (MCU) media franchise who is based on the Marvel Comics character
Nintedanib (2,666 words) [view diff] exact match in snippet view article find links to article
nintedanib group compared to the placebo group. Nintedanib was granted orphan drug designation in the US by the FDA for the treatment of idiopathic pulmonary
Mepolizumab (976 words) [view diff] no match in snippet view article find links to article
Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis
Freddy Krueger (4,704 words) [view diff] no match in snippet view article find links to article
Freddy Krueger (/ˈkruːɡər/) is a fictional character in the A Nightmare on Elm Street film series. He first appeared in Wes Craven's A Nightmare on Elm
Selpercatinib (1,204 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for selpercatinib priority review, orphan drug, and breakthrough therapy designations and granted approval of Retevmo
Constitutive androstane receptor (2,229 words) [view diff] exact match in snippet view article find links to article
Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD (Mar 1994). "A new orphan member of the nuclear hormone receptor superfamily that interacts with a
Nivolumab (3,263 words) [view diff] no match in snippet view article find links to article
Nivolumab, sold under the brand name Opdivo, is a medication used to treat a number of types of cancer. This includes melanoma, lung cancer, malignant
Echovirus (390 words) [view diff] exact match in snippet view article find links to article
enteric disease in humans. The name is derived from "enteric cytopathic human orphan virus". These viruses were originally not associated with disease but many
Chugai Pharmaceutical Co. (597 words) [view diff] exact match in snippet view article find links to article
launched. 2020 – FDA approved satralizumab (Enspryng) for treatment of the orphan disease neuromyelitis optica. Biotech and pharmaceutical companies in the
Brain-specific angiogenesis inhibitor 3 (524 words) [view diff] exact match in snippet view article find links to article
and may also play a role in angiogenesis. }} The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI
Peter Quill (Marvel Cinematic Universe) (2,833 words) [view diff] no match in snippet view article
Peter Quill is a fictional character portrayed by Chris Pratt in the Marvel Cinematic Universe (MCU) film franchise, sometimes known as Star-Lord, based
Carboprost (557 words) [view diff] no match in snippet view article find links to article
Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α)
GPR64 (1,155 words) [view diff] exact match in snippet view article find links to article
GPCR-Autoproteolysis INducing (GAIN) domain. The adhesion GPCR, GPR64, is an orphan receptor characterized by a long N-terminus with that has been suggested
Appian Way Productions (2,932 words) [view diff] exact match in snippet view article find links to article
Clooney’s Golden Globe nominated The Ides of March, the psychological thriller Orphan and the film adaptation of Dennis Lehane’s critically acclaimed novel Live
Pimozide (1,003 words) [view diff] exact match in snippet view article find links to article
schizophrenia. In 1985 the pimozide was approved by the FDA for marketing as an orphan drug for the treatment of Tourette's syndrome. Medicine portal Amisulpride
Icatibant (496 words) [view diff] exact match in snippet view article find links to article
effects of icatibant on the bradykinin B1 receptor. Icatibant received orphan drug status in Australia, the EU, Switzerland and the US for the treatment
Kato (The Green Hornet) (3,219 words) [view diff] no match in snippet view article
Kato is a fictional character from The Green Hornet series. This character has appeared with the Green Hornet in film, television, book and comic book
Peeta Mellark (2,594 words) [view diff] no match in snippet view article find links to article
Peeta Mellark is a fictional character from The Hunger Games trilogy by Suzanne Collins. He is portrayed by actor Josh Hutcherson in The Hunger Games film
Trehalose (1,835 words) [view diff] no match in snippet view article find links to article
Trehalose (from Turkish 'trehala' – a sugar derived from insect cocoons + -ose) is a sugar consisting of two molecules of glucose. It is also known as
Trabectedin (1,502 words) [view diff] exact match in snippet view article find links to article
European Commission and the U.S. Food and Drug Administration (FDA) granted orphan drug status to trabectedin for soft-tissue sarcomas and ovarian cancer.
GPRC5D (224 words) [view diff] exact match in snippet view article find links to article
function of this gene has not yet been determined. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000111291 -
Shelleyan Orphan (762 words) [view diff] exact match in snippet view article find links to article
Shelleyan Orphan were a British alternative music group that peaked during the 1980s and early 1990s. In 1980, Caroline Crawley and Jemaur Tayle met in
Annie (1999 film) (1,963 words) [view diff] exact match in snippet view article
Martin Charnin, and Thomas Meehan, which in turn is based on the 1924 Little Orphan Annie comic strip by Harold Gray. It was directed by Rob Marshall, written
Sanofi (7,701 words) [view diff] exact match in snippet view article find links to article
headquartered in Cambridge, Massachusetts specializes in the treatment of orphan diseases, renal diseases, endocrinology, oncology and biosurgery. In January
Pembrolizumab (5,194 words) [view diff] exact match in snippet view article find links to article
studies to ensure that the results are valid. Pembrolizumab was granted orphan drug designation for SCLC in October 2017. In June 2018, the US FDA approved
John Hunt Morgan (3,190 words) [view diff] no match in snippet view article find links to article
John H. Morgan (June 1, 1825 – September 4, 1864) was a Confederate general in the American Civil War. In April 1862, he raised the 2nd Kentucky Cavalry
Receptor tyrosine kinase-like orphan receptor (85 words) [view diff] exact match in snippet view article find links to article
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in
Winston Smith (794 words) [view diff] no match in snippet view article find links to article
Winston Smith is a fictional character and the protagonist of George Orwell's dystopian 1949 novel Nineteen Eighty-Four. The character was employed by
List of Drawn Together episodes (176 words) [view diff] exact match in snippet view article find links to article
Musical number: "The Board of Education" and "Fire the Load" 10 3 "Little Orphan Hero" Ray Claffey Erik Sommers November 2, 2005 (2005-11-02) 203 After discovering
Orion Arm (993 words) [view diff] exact match in snippet view article find links to article
interstellar masers in HMSFRs have been shown that the Local arm appears to be an orphan segment of an arm between the Sagittarius and Perseus arms that wraps around
Treprostinil (1,571 words) [view diff] exact match in snippet view article find links to article
Patient Package Insert. United Therapeutics Corp. 2013. Rare Disease and Orphan Drug Designated Approvals 2013 "Orenitram" (PDF). Full Prescribing Information
Loki (Marvel Cinematic Universe) (4,225 words) [view diff] no match in snippet view article
Loki Laufeyson, also known as Loki Odinson, is a character portrayed by Tom Hiddleston in the Marvel Cinematic Universe (MCU) film franchise, based on
Krallice (1,017 words) [view diff] exact match in snippet view article find links to article
year they released a single titled Traditional, as well as the cover EP Orphans of Sickness. Krallice independently released their fourth full-length album
Capmatinib (950 words) [view diff] exact match in snippet view article find links to article
approval program and granted the application for capmatinib priority review, orphan drug, and breakthrough therapy designations and granted the approval of
Armenian Orphan Rug (2,009 words) [view diff] exact match in snippet view article find links to article
The Armenian Orphan Rug, also known as the Ghazir Orphans' Rug, is an Armenian styled carpet woven by orphans of the Armenian Genocide in Ghazir, Lebanon
Ixazomib (1,570 words) [view diff] exact match in snippet view article find links to article
can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative. The
Actelion (2,427 words) [view diff] exact match in snippet view article find links to article
Actelion focuses on the manufacture of drugs that treat rare diseases and orphan diseases.[failed verification] Some of the drugs it has produced have been
Orochimaru (Naruto) (3,785 words) [view diff] no match in snippet view article
Orochimaru (大蛇丸) is a fictional character from Naruto, a manga series created by Masashi Kishimoto. In the anime and manga, Orochimaru is a former ninja
Honey Ryder (1,123 words) [view diff] exact match in snippet view article find links to article
shell diver, descended from an old-established colonial family. She was orphaned at the age of five when her parents' house was burned down. She then lived
Tolvaptan (650 words) [view diff] exact match in snippet view article find links to article
the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant
Tetrahydrobiopterin (2,438 words) [view diff] no match in snippet view article find links to article
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation
Monster Study (2,093 words) [view diff] exact match in snippet view article find links to article
The Monster Study was a stuttering experiment performed on 22 orphan children in Davenport, Iowa in 1939. It was conducted by Wendell Johnson at the University
Busulfan (1,216 words) [view diff] no match in snippet view article find links to article
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific
Azacitidine (1,673 words) [view diff] no match in snippet view article find links to article
Azacitidine, sold under the brand name Vidaza among others, is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative
Rucaparib (1,099 words) [view diff] exact match in snippet view article find links to article
pretreated advanced ovarian cancer. In the European Union it was designated an orphan medicinal product on 10 October 2012. On 22 March 2018, the Committee for
Honey Ryder (1,123 words) [view diff] exact match in snippet view article find links to article
shell diver, descended from an old-established colonial family. She was orphaned at the age of five when her parents' house was burned down. She then lived
Chlormethine (1,668 words) [view diff] no match in snippet view article find links to article
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard
Charlie Dog (831 words) [view diff] exact match in snippet view article find links to article
two more Charlie Dog/Porky Pig cartoons in 1949: Awful Orphan (29 January) and Often an Orphan (13 August). Jones also starred Charlie without Porky in
Tolvaptan (650 words) [view diff] exact match in snippet view article find links to article
the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant
Daddy Warbucks (1,375 words) [view diff] exact match in snippet view article find links to article
Oliver "Daddy" Warbucks is a fictional character from the comic strip Little Orphan Annie. He made his first appearance in the New York Daily News in the Annie
Monster Study (2,093 words) [view diff] exact match in snippet view article find links to article
The Monster Study was a stuttering experiment performed on 22 orphan children in Davenport, Iowa in 1939. It was conducted by Wendell Johnson at the University
Tetrahydrobiopterin (2,438 words) [view diff] no match in snippet view article find links to article
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation
GPR15 (1,451 words) [view diff] exact match in snippet view article find links to article
GPR15 is a class A orphan G protein-coupled receptor (heterotrimeric guanine nucleotide-binding protein, GPCR). The GPR15 gene is localized at chromosome
ViroPharma (766 words) [view diff] exact match in snippet view article find links to article
Makiko (11 November 2013). "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg. Pollack, Andrew (9 November 2005). "Crucial Antibiotic
Novo Nordisk (2,001 words) [view diff] no match in snippet view article find links to article
Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd, Denmark, with production facilities in eight countries, and
Takeda Pharmaceutical Company (2,216 words) [view diff] no match in snippet view article find links to article
The Takeda Pharmaceutical Company Limited (武田薬品工業株式会社, Takeda Yakuhin Kōgyō kabushiki gaisha) [takeꜜda jakɯçiŋ koꜜːɡʲoː] is a Japanese multinational pharmaceutical
Naxitamab (536 words) [view diff] exact match in snippet view article find links to article
the application for naxitamab priority review, breakthrough therapy, and, orphan drug designations. The FDA issued a priority review voucher for this rare
Like Mike (1,123 words) [view diff] exact match in snippet view article find links to article
Lipnicki, Robert Forster, Crispin Glover and Eugene Levy, the film follows an orphan who gets basketball talents after finding a pair of Michael Jordan's shoes
Nitisinone (858 words) [view diff] exact match in snippet view article find links to article
nitisinone being brought to market as an orphan drug Swedish Orphan International, which was later acquired by Swedish Orphan Biovitrum (Sobi).[citation needed]
Edward Cullen (3,679 words) [view diff] no match in snippet view article find links to article
Edward Cullen (né Edward Anthony Masen, Jr.) is a fictional character in Stephenie Meyer's Twilight series. He is featured in the books Twilight, New Moon
Pregnane X receptor (1,962 words) [view diff] exact match in snippet view article find links to article
Watson MA, Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene
Gaara (3,823 words) [view diff] no match in snippet view article find links to article
Gaara (我愛羅) is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto. Originally debuting as an antagonist, Gaara is
Sorafenib (2,448 words) [view diff] no match in snippet view article find links to article
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary
3rd Canadian Screen Awards (206 words) [view diff] exact match in snippet view article find links to article
13 nominations, while on the television side the science fiction series Orphan Black also received 13 nominations. The awards ceremony were hosted by Andrea
Pitolisant (735 words) [view diff] exact match in snippet view article find links to article
U.S. Food and Drug Administration (FDA) in August 2019. It was granted orphan drug designation for the treatment of narcolepsy, fast track designation
Merck & Co. (8,165 words) [view diff] exact match in snippet view article find links to article
antibody-drug conjugate, VLS-101, designed to target Tyrosine kinase-like orphan receptor 1 (ROR1) in both hematological and solid tumors. VLS-101 is currently
Cladribine (3,089 words) [view diff] exact match in snippet view article find links to article
pharmaceutical companies were interested in selling the drug because HCL was an orphan disease, so Beutler's lab synthesized and packaged it and supplied it to
Pazopanib (1,267 words) [view diff] no match in snippet view article find links to article
Pazopanib, sold under the brand name Votrient, is an anti-cancer medication. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor
F-15,599 (568 words) [view diff] exact match in snippet view article find links to article
gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease. F-15,599 was discovered and initially developed by Pierre Fabre
Dasatinib (1,938 words) [view diff] no match in snippet view article find links to article
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia
Time's Orphan (816 words) [view diff] exact match in snippet view article find links to article
"Time's Orphan" is the 148th episode of the syndicated American science fiction television series Star Trek: Deep Space Nine, the 24th episode of the sixth
Peter Sarsgaard (4,670 words) [view diff] exact match in snippet view article find links to article
films such as Flightplan (2005), Jarhead (2005), The Skeleton Key (2005), Orphan (2009), An Education (2009), Knight and Day (2010), Green Lantern (2011)
Mikołaj Krzysztof "the Orphan" Radziwiłł (1,075 words) [view diff] exact match in snippet view article find links to article
Radvila Našlaitėlis) (2 Augustus 1549 – 28 February 1616) and nicknamed "the Orphan" (Lithuanian: Našlaitėlis, Polish: Sierotka), was a Polish–Lithuanian nobleman
Omacetaxine mepesuccinate (773 words) [view diff] no match in snippet view article find links to article
Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated
Metreleptin (511 words) [view diff] no match in snippet view article find links to article
Metreleptin, sold under the brand name Myalept among others, is a synthetic analog of the hormone leptin used to treat various forms of dyslipidemia. It
Batman and Robin Eternal (1,124 words) [view diff] exact match in snippet view article find links to article
one of Mother's agents calling himself the Orphan. Cassandra Cain saves her, then chases after the Orphan. Dick meets Harper and her roommate Stephanie
Rifampicin (4,607 words) [view diff] no match in snippet view article find links to article
Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections, including tuberculosis, Mycobacterium avium complex
Runaway (dependent) (1,597 words) [view diff] no match in snippet view article
A runaway is a minor or (depending upon the local jurisdiction) a person under a specified age, who has left their parents or legal guardians without permission
List of Marvel Comics characters: O (3,547 words) [view diff] no match in snippet view article find links to article
0–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Blackjack O'Hare is a fictional anthropomorphic hare in Marvel Comics. The character, created by
Huerfano Butte (357 words) [view diff] exact match in snippet view article find links to article
Walsenburg in Huerfano County, Colorado, United States. Named Huerfano (English: orphan) by early Spanish explorers, it rises above the south side of the Huerfano
TLX (937 words) [view diff] exact match in snippet view article find links to article
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and Cellular Biology. 20 (23): 8731–9.
Bombesin-like receptor 3 (799 words) [view diff] exact match in snippet view article find links to article
therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor. GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
Sacituzumab govitecan (1,654 words) [view diff] exact match in snippet view article find links to article
small cell lung cancer, and metastatic triple-negative breast cancer. Orphan drug status was granted for small cell lung cancer and pancreatic cancer
Laura Dern (2,874 words) [view diff] exact match in snippet view article find links to article
She received an Academy Award nomination for her portrayal of the titular orphan in the drama film Rambling Rose (1991) and achieved international recognition
Iloprost (1,241 words) [view diff] no match in snippet view article find links to article
Iloprost is a medication used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels
Hoffmann-La Roche (4,238 words) [view diff] no match in snippet view article find links to article
Coordinates: 47°33′31″N 7°36′22″E / 47.558624°N 7.606018°E / 47.558624; 7.606018 F. Hoffmann-La Roche AG is a Swiss multinational healthcare company
Binandere language (180 words) [view diff] exact match in snippet view article find links to article
(Guhu-Samane burisi eetaqu ‘turn over, turn s.th. around’) *mbeŋga-masi ‘orphan’, ‘widow and child’ (Suena boga masa ‘destitute widow and child’) *pu +
Margo Martindale (1,631 words) [view diff] exact match in snippet view article find links to article
Lorenzo's Oil, ...First Do No Harm, Eye of God, Win Win, Marvin's Room, Forged, Orphan, The Savages, Hannah Montana: The Movie, August: Osage County, and Paris
Mecasermin rinfabate (1,225 words) [view diff] no match in snippet view article find links to article
Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor
Thomas John Barnardo (1,558 words) [view diff] exact match in snippet view article find links to article
Victorian London. Many of these children were not only impoverished, but orphaned, as the result of a recent cholera outbreak. For those unable to afford
Treosulfan (501 words) [view diff] exact match in snippet view article find links to article
fludarabine) were alive 3 months after their transplant. On 23 February 2004, orphan designation (EU/3/04/186) was granted by the European Commission to medac
STI College (693 words) [view diff] exact match in snippet view article find links to article
administration, and computer science. The acronym STI has been declared as an orphan initialism after their name change in 2006. STI uses a trimester calendar
Park County, Colorado (1,167 words) [view diff] exact match in snippet view article find links to article
been and is the location of several important mines, including the defunct Orphan Boy, which was discovered near Alma in 1861 and produced gold, silver, lead
Treosulfan (501 words) [view diff] exact match in snippet view article find links to article
fludarabine) were alive 3 months after their transplant. On 23 February 2004, orphan designation (EU/3/04/186) was granted by the European Commission to medac
STI College (693 words) [view diff] exact match in snippet view article find links to article
administration, and computer science. The acronym STI has been declared as an orphan initialism after their name change in 2006. STI uses a trimester calendar
CCH Pounder (1,064 words) [view diff] exact match in snippet view article find links to article
Joon (1993), Demon Knight (1995), Face/Off (1997), End of Days (1999), Orphan (2009), Avatar (2009), The Mortal Instruments: City of Bones (2013), and
Ōshima Strait (63 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
Tiopronin (562 words) [view diff] exact match in snippet view article find links to article
rarity of the disorder, tiopronin falls under the classification of an orphan drug. It is somewhat similar to penicillamine in both chemistry and pharmacology
Nilotinib (1,670 words) [view diff] no match in snippet view article find links to article
Nilotinib, sold under the brand name Tasigna, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It
Paromomycin (1,358 words) [view diff] no match in snippet view article find links to article
Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection.
Romidepsin (1,416 words) [view diff] exact match in snippet view article find links to article
designation from the FDA for the treatment of cutaneous T-cell lymphoma, and orphan drug status from the FDA and the European Medicines Agency for the same
Lanadelumab (1,004 words) [view diff] exact match in snippet view article find links to article
this trial, Lanadelumab was given Priority Review, Breakthrough Therapy, Orphan Drug designation by the FDA. The phase 3 HELP study evaluated efficacy and
Qi'ra (2,427 words) [view diff] exact match in snippet view article find links to article
Wars Anthology film Solo: A Star Wars Story, Qi'ra is introduced as an orphaned street thief living on the shipbuilding world of Corellia. She and her
Tislelizumab (446 words) [view diff] no match in snippet view article find links to article
Tislelizumab (BGB-A317) is a humanized monoclonal antibody directed against PD-1. It prevents PD-1 from binding to the ligands PD-L1 and PD-L2 (hence it
Otelixizumab (678 words) [view diff] exact match in snippet view article find links to article
failed to show efficacy of the treatment. Otelixizumab has been granted "orphan drug" status by the U.S. Food and Drug Administration. As a monoclonal antibody
Snow White (Disney character) (3,695 words) [view diff] no match in snippet view article
Snow White is a fictional character and a main character from Walt Disney Productions' first animated feature film Snow White and the Seven Dwarfs (1937)
Peter Parker (Marvel Cinematic Universe) (4,726 words) [view diff] exact match in snippet view article
on which he had collaborated with Joe Simon in the 1950s, in which an orphaned boy living with an old couple finds a magic ring that granted him superhuman
Carmustine (569 words) [view diff] no match in snippet view article find links to article
Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound
Melatonin (9,423 words) [view diff] no match in snippet view article find links to article
Melatonin is a hormone primarily released by the pineal gland at night, and has long been associated with control of the sleep–wake cycle. As a dietary
Mecasermin rinfabate (1,225 words) [view diff] no match in snippet view article find links to article
Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor
Lintuzumab (505 words) [view diff] exact match in snippet view article find links to article
Administration and the European Medicines Agency had granted lintuzumab orphan drug status for treatment of AML and myelodysplastic syndromes. Seattle
ROR2 (1,109 words) [view diff] exact match in snippet view article find links to article
brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
Natasha Romanoff (Marvel Cinematic Universe) (7,123 words) [view diff] no match in snippet view article
Natasha Romanoff is a fictional character portrayed by Scarlett Johansson in the Marvel Cinematic Universe (MCU) film franchise—based on the Marvel Comics
Rovalpituzumab tesirine (395 words) [view diff] no match in snippet view article find links to article
Rovalpituzumab tesirine (Rova-T) is an experimental antibody-drug conjugate targeting the protein DLL3 on tumor cells. It was originally developed by Stemcentrx
Shire (pharmaceutical company) (2,178 words) [view diff] exact match in snippet view article
Retrieved 26 March 2016. "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg. 11 November 2013. Retrieved 26 March 2016. Trista Kelley
Adam Johnson (writer) (1,419 words) [view diff] exact match in snippet view article
and short story writer. He won the Pulitzer Prize for his 2012 novel, The Orphan Master's Son, and the National Book Award for his 2015 story collection
Harold Gray (1,129 words) [view diff] exact match in snippet view article find links to article
cartoonist, best known as the creator of the newspaper comic strip Little Orphan Annie. Harold Gray was born in Kankakee, Illinois on January 20, 1894, to
Dick Grayson (1989 film series character) (2,265 words) [view diff] no match in snippet view article
Dick Grayson, better known by his superhero alias Robin, is a fictional character from Joel Schumacher's superhero films Batman Forever (1995) and Batman
Rey (Star Wars) (7,021 words) [view diff] exact match in snippet view article
learning that she has to connect with herself. Rey is first introduced as an orphan living alone on the desert planet Jakku, scraping a living through scavenging
Margetuximab (518 words) [view diff] exact match in snippet view article find links to article
gastric cancer and esophageal cancer.[needs update] In June 2020, it received orphan drug designation from the U.S. Food and Drug Administration (FDA). Efficacy
KiSS1-derived peptide receptor (1,897 words) [view diff] exact match in snippet view article find links to article
suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry.
New York City draft riots (4,477 words) [view diff] exact match in snippet view article find links to article
various abolitionists or sympathizers, many black homes, and the Colored Orphan Asylum at 44th Street and Fifth Avenue, which was burned to the ground.
William Matthews (priest) (7,313 words) [view diff] exact match in snippet view article
and president of St. Vincent's Female Orphan Asylum and the co-founder and president of St. Joseph's Male Orphan Asylum. He played a significant role in
Brentuximab vedotin (1,794 words) [view diff] no match in snippet view article find links to article
Brentuximab vedotin (INN; trade name Adcetris) is an antibody-drug conjugate medication used to treat relapsed or refractory Hodgkin lymphoma (HL) and
Clear Paddock Creek (161 words) [view diff] exact match in snippet view article find links to article
Clear Paddock Creek is a tributary of Orphan School Creek, which in turn, is a tributary of Prospect Creek, located in the City of Fairfield, NSW. It flows
Ranibizumab (2,084 words) [view diff] no match in snippet view article find links to article
Ranibizumab (trade name Lucentis among others) is a monoclonal antibody fragment (Fab) created from the same parent mouse antibody as bevacizumab. It is
The Shakespeare Stealer (611 words) [view diff] exact match in snippet view article find links to article
place in the Elizabethan-era England, it recounts the story of Widge, an orphan whose master sends him to steal Hamlet from The Lord Chamberlain's Men.
Ranirestat (298 words) [view diff] exact match in snippet view article find links to article
neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin. It has been granted orphan drug status. The drug is to be used orally. A Canadian Phase III clinical
Elotuzumab (1,158 words) [view diff] no match in snippet view article find links to article
Elotuzumab, sold under the brand name Empliciti, is a humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone
Bristol Myers Squibb (4,726 words) [view diff] no match in snippet view article find links to article
Bristol Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City. Bristol Myers Squibb manufactures prescription pharmaceuticals
Spectrum Pharmaceuticals (502 words) [view diff] no match in snippet view article find links to article
Spectrum Pharmaceuticals is an American biopharmaceutical company. The company is located in Irvine, California. Spectrum develops and markets drugs for
GPR1 (584 words) [view diff] exact match in snippet view article find links to article
PMC 2224232. PMID 18165312. Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication
GPR42 (227 words) [view diff] exact match in snippet view article find links to article
PMID 15684720. Brown AJ, Goldsworthy SM, Barnes AA, et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate
GPR55 (1,690 words) [view diff] exact match in snippet view article find links to article
a relevant role in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in oncology
Crizanlizumab (538 words) [view diff] exact match in snippet view article find links to article
crizanlizumab-tmca priority review, breakthrough therapy designation, and orphan drug designation. The FDA granted approval of Adakveo to Novartis. "Crizanlizumab
Alexion Pharmaceuticals (2,724 words) [view diff] no match in snippet view article find links to article
Alexion Pharmaceuticals Inc. is an American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical
Silly Symphony (1,886 words) [view diff] exact match in snippet view article find links to article
to this include Three Little Pigs, The Tortoise and the Hare, and Three Orphan Kittens, which all had sequels). The series is notable for its innovation
Maniac Magee (1,712 words) [view diff] exact match in snippet view article find links to article
Exploring themes of racism and inequality, it follows the story of an orphan boy looking for a home in the fictional town of Two Mills. Two Mills is
Liver X receptor (2,765 words) [view diff] exact match in snippet view article find links to article
cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands
V-erbA-related gene (1,017 words) [view diff] exact match in snippet view article find links to article
Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear
4th Canadian Screen Awards (372 words) [view diff] exact match in snippet view article find links to article
Ari Millen, Orphan Black Aaron Poole, Strange Empire Adrian Holmes, 19-2 Ben Bass, Rookie Blue Jared Keeso, 19-2 Tatiana Maslany, Orphan Black Jennie
Orphan: First Kill (339 words) [view diff] exact match in snippet view article find links to article
Orphan: First Kill is an upcoming American horror film, directed by William Brent Bell, from a screenplay by David Coggeshall. It is a prequel to the 2009
GPCR neuropeptide receptor (261 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Inigo Montoya (930 words) [view diff] no match in snippet view article find links to article
Inigo Montoya is a fictional character in William Goldman's 1973 novel The Princess Bride. In Rob Reiner's 1987 film adaptation, he was portrayed by Mandy
John Fawcett (director) (473 words) [view diff] exact match in snippet view article
director for the award-winning BBC America and Space sci-fi television series Orphan Black. Fawcett began his career making commercials before moving on to direct
Inebilizumab (890 words) [view diff] exact match in snippet view article find links to article
and Drug Administration (FDA) granted the application for inebilizumab orphan drug designation and granted approval of Uplizna to Viela Bio. Inebilizumab
GPR20 (195 words) [view diff] exact match in snippet view article find links to article
Yokomizo T, Shimizu T, Nakamura M (May 2008). "Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins"
Rhoticity in English (7,995 words) [view diff] exact match in snippet view article find links to article
as boss–bourse. Specifically, the phonemic merger of the words often and orphan was a running gag in the Gilbert and Sullivan musical, The Pirates of Penzance
Tacrolimus (3,797 words) [view diff] no match in snippet view article find links to article
Tacrolimus, sold under the brand names Protopic and Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of
Small nucleolar RNA (3,571 words) [view diff] exact match in snippet view article find links to article
loops in the snoRNA sequence. However, there are increasing numbers of 'orphan' guides without any known RNA targets, which suggests that there might be
GPR3 (844 words) [view diff] exact match in snippet view article find links to article
Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase"
Germ cell nuclear factor (917 words) [view diff] exact match in snippet view article find links to article
Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated
Hefner (band) (1,085 words) [view diff] exact match in snippet view article
Hefner Soul - Too Pure - 1998 The Hefner Heart - Acuarela Discos - 1999 Orphan Songs - Everlasting Records - 1999 Revelations - Too Pure - 1999 The Hefner
Amatuximab (927 words) [view diff] exact match in snippet view article find links to article
amatuximab orphan drug status for use in malignant pleural mesothelioma in November 2012, and the European Commission soon followed granting orphan drug status
Neuropeptides B/W receptor 2 (457 words) [view diff] exact match in snippet view article find links to article
(2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32
Vancouver Orphan Kitten Rescue Association (2,707 words) [view diff] exact match in snippet view article find links to article
The Vancouver Orphan Kitten Rescue Association (VOKRA) is a no kill, non-profit cat rescue organization in Vancouver, British Columbia, Canada, providing
GPR77 (697 words) [view diff] exact match in snippet view article find links to article
1016/S0161-5890(00)00067-5. PMID 11090875. Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a
Brain Powerd (2,343 words) [view diff] exact match in snippet view article find links to article
discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies"
Rifapentine (961 words) [view diff] exact match in snippet view article find links to article
made from rifampicin.[medical citation needed] Rifapentine was granted orphan drug designation by the FDA in June 1995, and by the European Commission
Naruto Uzumaki (12,666 words) [view diff] exact match in snippet view article find links to article
felt it was something common in Japanese series. Introduced as a young orphan boy of 12 years with blond, spiky hair and blue eyes, Naruto Uzumaki graduates
Rickon Stark (1,758 words) [view diff] no match in snippet view article find links to article
Rickon Stark is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Panobinostat (1,160 words) [view diff] no match in snippet view article find links to article
Panobinostat (trade name Farydak /ˈfɛərədæk/ FAIR-ə-dak) is a drug by Novartis for the treatment of various cancers. It is a hydroxamic acid and acts as
Baxter International (3,445 words) [view diff] no match in snippet view article find links to article
Baxter International Inc. is an American multinational health care company with headquarters in Deerfield, Illinois. The company primarily focuses on products
Atezolizumab (3,634 words) [view diff] no match in snippet view article find links to article
Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC)
Cascadia subduction zone (3,808 words) [view diff] exact match in snippet view article find links to article
Since no earthquake had been observed to produce it, scholars dubbed it an "orphan tsunami." Translating the Japanese calendar, Satake found the incident had
GPR139 (326 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Jyn Erso (2,299 words) [view diff] no match in snippet view article find links to article
Jyn Erso is a fictional character in the Star Wars franchise, portrayed by English actress Felicity Jones in the 2016 film Rogue One. Jyn aids the Rebel
Peaches (musician) (3,419 words) [view diff] exact match in snippet view article
Translation. Her music has also been featured on television shows such as Orphan Black, Lost Girl, The L Word, South Park, Skam, The Handmaid's Tale, 30
Neuropeptide S receptor (1,696 words) [view diff] exact match in snippet view article find links to article
membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous
Ciclosporin (4,546 words) [view diff] no match in snippet view article find links to article
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It
Acalabrutinib (1,049 words) [view diff] exact match in snippet view article find links to article
and was similarly designated as an orphan medicinal product by the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP) for treatment
Loncastuximab tesirine (479 words) [view diff] exact match in snippet view article find links to article
response and 14% partial response). Loncastuximab tesirine was granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the
Oerba Yun Fang (1,213 words) [view diff] no match in snippet view article find links to article
Oerba Yun Fang (ヲルバ=ユン・ファング, Woruba-Yun Fangu, Fang of the Yun clan from the village of Oerba) is a fictional character in the 2009 video game Final Fantasy
SUCNR1 (303 words) [view diff] exact match in snippet view article find links to article
Tian H, Ling L (May 2004). "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors". Nature. 429 (6988): 188–93. doi:10.1038/nature02488
GPR142 (221 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Iva Toguri D'Aquino (2,808 words) [view diff] exact match in snippet view article find links to article
during World War II on The Zero Hour radio show. Toguri called herself "Orphan Ann", but she quickly became inaccurately identified with the name "Tokyo
Children's Aid Society (1,536 words) [view diff] exact match in snippet view article find links to article
adults. Brace was appalled by the thousands of abandoned, abused, and orphaned children living in the slums and on the streets of New York at the time
James Frain (653 words) [view diff] exact match in snippet view article find links to article
The Tunnel (2013), Ferdinand Chevalier in the BBC/Space sci-fi thriller Orphan Black (2015–2017), Theo Galavan/Azrael in Fox's Gotham (2015–2016), and
TLX3 (824 words) [view diff] exact match in snippet view article find links to article
is encoded by the TLX3 gene. RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members
Olaparib (1,885 words) [view diff] no match in snippet view article find links to article
Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a
Al-Ma'un (1,542 words) [view diff] exact match in snippet view article find links to article
denieth the future judgment as a falsehood? ۝ It is he who pusheth away the orphan; ۝ and stirreth not up others to feed the poor. ۝ Woe be unto those who
Comic Strip Classics (146 words) [view diff] exact match in snippet view article find links to article
Goldberg’s Inventions Toonerville Folks Gasoline Alley Barney Google Little Orphan Annie Popeye Blondie Dick Tracy Alley Oop Nancy Flash Gordon Li'l Abner
Doctor Who (series 12) (4,696 words) [view diff] exact match in snippet view article
"Spyfall, Part 2". James Buckley appeared in "Orphan 55" as Nevi. Laura Fraser also appeared in "Orphan 55" as Kane, as did Julia Foster as Vilma. Goran
Linsitinib (279 words) [view diff] exact match in snippet view article find links to article
proliferation and induces tumor cell apoptosis. Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012. Phase II clinical
Samus Aran (5,231 words) [view diff] exact match in snippet view article find links to article
Ridley in an attack that killed her parents and destroyed the colony. The orphaned Samus was then found by a bird-like alien race known as the Chozo, who
Oerba Dia Vanille (1,216 words) [view diff] exact match in snippet view article find links to article
her Eidolon, Hecatoncheir, manifests, and she and Fang defeat it. After Orphan's defeat, she and Fang transform into Ragnarok and form a crystal pillar
Huerfano County, Colorado (1,253 words) [view diff] exact match in snippet view article find links to article
Walsenburg. The county, whose name comes from the Spanish huérfano meaning "orphan", was named for the Huerfano Butte, a local landmark. The area of Huerfano
4-Aminopyridine (1,829 words) [view diff] no match in snippet view article find links to article
4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric
Vegeta (5,900 words) [view diff] no match in snippet view article find links to article
Vegeta (Japanese: ベジータ, Hepburn: Bejīta) (/vəˈdʒiːtə/ və-JEE-tə), also known as Prince Vegeta (ベジータ王子, Bejīta-ōji) or alternatively styled as Vegeta IV
Ivacaftor (3,047 words) [view diff] exact match in snippet view article find links to article
M. Orenstein; Carlos E. Milla (2 October 2013). "Viewpoint: Pricing for Orphan Drugs: Will the Market Bear What Society Cannot?". JAMA. 310 (13): 1343–1344
Isatuximab (3,034 words) [view diff] exact match in snippet view article find links to article
have demonstrated disease progression on the last therapy. It was granted orphan drug designation for multiple myeloma by the European Medicines Agency (EMA)
Squall Leonhart (4,251 words) [view diff] exact match in snippet view article find links to article
in an orphanage with the other playable characters, except Rinoa. The orphans were cared for by Edea; although Squall remembers little about his past
Ursodeoxycholic acid (1,902 words) [view diff] exact match in snippet view article find links to article
approved for use in the United States in December 1987, and was designated an orphan drug. Chenodeoxycholic acid—an epimer Hyodeoxycholic acid—an isomer "Ursodiol
Acanthamoeba keratitis (2,777 words) [view diff] exact match in snippet view article find links to article
important to vision. Recently, AK has been recognized as an orphan disease and a funded project, orphan diseases Acanthamoeba keratitis (ODAK), has tested the
Eribulin (2,015 words) [view diff] exact match in snippet view article find links to article
population, Eisai was able to file a New Drug Application (NDA) under the orphan and rare disease designation. On January 28, 2016, the U.S. Food and Drug
Babacar (band) (259 words) [view diff] exact match in snippet view article
rock supergroup formed in England, featuring former members of Shelleyan Orphan, The Cure, and Presence. The group released one album in their brief existence
Zenarestat (96 words) [view diff] no match in snippet view article find links to article
Zenarestat (FK-366; FR-74366) is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract, but its development
Doctor Who (series 12) (4,696 words) [view diff] exact match in snippet view article
"Spyfall, Part 2". James Buckley appeared in "Orphan 55" as Nevi. Laura Fraser also appeared in "Orphan 55" as Kane, as did Julia Foster as Vilma. Goran
Zanubrutinib (656 words) [view diff] exact match in snippet view article find links to article
priority review, accelerated approval, breakthrough therapy designation, and orphan drug designation. The FDA approved zanubrutinib in November 2019, and granted
Sasuke Uchiha (8,949 words) [view diff] no match in snippet view article find links to article
Sasuke Uchiha (Japanese: うちは サスケ, Hepburn: Uchiha Sasuke) (/ˈsɑːskeɪ/) is a fictional character in the Naruto manga and anime franchise created by Masashi
Oerba Dia Vanille (1,216 words) [view diff] exact match in snippet view article find links to article
her Eidolon, Hecatoncheir, manifests, and she and Fang defeat it. After Orphan's defeat, she and Fang transform into Ragnarok and form a crystal pillar
Gilteritinib (508 words) [view diff] exact match in snippet view article find links to article
mutation as detected by an FDA-approved test. Gilteritinib was granted orphan drug status by the U.S. FDA, the European Commission (EC) and the Japan
Little Orphan Annie (1932 film) (235 words) [view diff] exact match in snippet view article
Little Orphan Annie is a 1932 American pre-Code comedy film directed by John S. Robertson, and written by Wanda Tuchock and Tom McNamara. It is based on
Karlani (251 words) [view diff] exact match in snippet view article find links to article
The legend of Karlani in the folklore says: "In his infancy he became an orphan and after losing his family he alone survived and was adopted by the Ormur
Satralizumab (1,338 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for satralizumab fast track and orphan drug designations. The FDA granted the approval of Enspryng to Genentech
Gusperimus (757 words) [view diff] exact match in snippet view article find links to article
Bristol-Myers Squibb. Currently, it is manufactured and sponsored for use as an orphan drug and for clinical studies by the Japanese company Euro Nippon Kayaku
Clofazimine (1,861 words) [view diff] exact match in snippet view article find links to article
Clarithromycin. However, in the United States, Clofazimine is considered an orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC
Urotensin-II receptor (2,078 words) [view diff] exact match in snippet view article find links to article
(1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14". Nature. 401 (6750): 282–6. doi:10.1038/45809. PMID 10499587
Hepatocyte nuclear factor 4 alpha (2,119 words) [view diff] exact match in snippet view article find links to article
F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (Feb 2003). "The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction
Oxytocin (10,495 words) [view diff] no match in snippet view article find links to article
Oxytocin (Oxt) is a peptide hormone and neuropeptide. It is normally produced in the hypothalamus and released by the posterior pituitary. It plays a role
Nimotuzumab (803 words) [view diff] exact match in snippet view article find links to article
Immunology, Havana, Cuba) is a humanized monoclonal antibody that as of 2014 had orphan status in the US and EU for glioma, and marketing approval in India, China
The Flash (season 5) (5,949 words) [view diff] case mismatch in snippet view article
Retrieved February 15, 2019. "TV REVIEW: THE FLASH S5 E16 - 'FAILURE IS AN ORPHAN'". Dynamic Forces. March 13, 2019. Retrieved April 19, 2019. "(#517) "Time
Heidi (1937 film) (1,365 words) [view diff] exact match in snippet view article
story of the same name by Swiss author Johanna Spyri. The film is about an orphan named Heidi (Temple) who is taken from her grandfather (Jean Hersholt) to
Scenic World (962 words) [view diff] exact match in snippet view article find links to article
Scenic World began building a roller coaster known as the Orphan Rocker, named after the nearby Orphan Rock. This is the first roller coaster to be completely
Natty Bumppo (1,323 words) [view diff] no match in snippet view article find links to article
Nathaniel "Natty" Bumppo is a fictional character and the protagonist of James Fenimore Cooper's pentalogy of novels known as the Leatherstocking Tales
COUP-TFI (1,468 words) [view diff] exact match in snippet view article find links to article
mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22
GPR32 (926 words) [view diff] exact match in snippet view article find links to article
initially identified and defined by molecular cloning in 1998 as coding for an orphan receptor, i.e. a protein with an amino acid sequence similar to known receptors
Tarextumab (79 words) [view diff] exact match in snippet view article find links to article
as a possible treatment for cancer. In January 2015, the US FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and
Tiratricol (388 words) [view diff] exact match in snippet view article find links to article
resistance and adjuvant therapy of thyroid cancer. It is available as an orphan drug to be prescribed by registered specialists in Europe. Carvalho GA,
Spinocerebellar ataxia (2,729 words) [view diff] exact match in snippet view article find links to article
Retrieved 2019-08-01. "Search Orphan Drug Designations and Approvals". www.accessdata.fda.gov. Retrieved 2019-08-01. "Search Orphan Drug Designations and Approvals"
GPR83 (325 words) [view diff] exact match in snippet view article find links to article
"Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83)". Cytogenet Cell Genet. 90 (1–2):
GlaxoSmithKline (10,039 words) [view diff] no match in snippet view article find links to article
GlaxoSmithKline plc (GSK) is a British multinational pharmaceutical company headquartered in London, England. Established in 2000 by a merger of Glaxo
Bran Stark (3,012 words) [view diff] exact match in snippet view article find links to article
Rickon go into hiding. To cement his claim on Winterfell, Theon has two orphan boys killed and their bodies burned, and passes their charred corpses off
Renly Baratheon (1,100 words) [view diff] no match in snippet view article find links to article
Renly Baratheon is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Orphan Black (comic book) (3,064 words) [view diff] exact match in snippet view article
Orphan Black is a limited series of comic books based on the television series Orphan Black, which airs on BBC America in the United States and Space
Defibrotide (1,247 words) [view diff] exact match in snippet view article find links to article
FDA granted the application for defibrotide priority review status and orphan drug designation. The FDA granted approval of Defitelio to Jazz Pharmaceuticals
Caffeine citrate (579 words) [view diff] no match in snippet view article find links to article
Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it
Michiel Huisman (1,810 words) [view diff] exact match in snippet view article find links to article
television such as Liam McGuinnis on Nashville (2012–14) and as Cal Morrison on Orphan Black (2014–15). Huisman began his career on Dutch television, in the Dutch
Laawaris (1981 film) (855 words) [view diff] exact match in snippet view article
Laawaris (transl. Orphan or Scoundrel ) is an 1981 Indian drama film directed by Prakash Mehra. The film became known for its song "Mere Angene Mein Tumhara
Special-purpose entity (1,292 words) [view diff] exact match in snippet view article find links to article
defeat the point of the securitization. Therefore, many SPEs are set up as 'orphan' companies with their shares settled on charitable trust and with professional
Yun and Yang (1,473 words) [view diff] no match in snippet view article find links to article
Yun (ユン) and Yang (ヤン, Yan) are a pair of fictional characters appearing in the Street Fighter fighting game series. The characters are twin brothers known
Fidaxomicin (1,157 words) [view diff] no match in snippet view article find links to article
Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins
Sailor Jupiter (3,366 words) [view diff] no match in snippet view article find links to article
Makoto Kino (木野 まこと, Kino Makoto, renamed "Lita Kino" in some English adaptations), better known as Sailor Jupiter (セーラージュピター, Sērā Jupitā), is a fictional
Rydia (1,108 words) [view diff] no match in snippet view article find links to article
Rydia of Mist (ミストのリディア, Misuto no Ridia) is a fictional character in the Final Fantasy series. She appears in Final Fantasy IV as one of its protagonists
GPR63 (384 words) [view diff] exact match in snippet view article find links to article
1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056
Faris Scherwiz (1,488 words) [view diff] no match in snippet view article find links to article
Faris Scherwiz is a fictional character in the Final Fantasy series. She first appears in Final Fantasy V as an early antagonist and later one of its protagonists
Jon Snow (character) (8,397 words) [view diff] exact match in snippet view article
introduced in A Game of Thrones (1996), as he and his five siblings adopt six orphaned direwolf cubs. Jon takes the runt of the litter, a white cub that he names
Garden of Eden (cellular automaton) (3,505 words) [view diff] exact match in snippet view article
a Garden of Eden if and only if it contains an orphan. For one-dimensional cellular automata, orphans and Gardens of Eden can be found by an efficient
GPR17 (1,797 words) [view diff] exact match in snippet view article find links to article
functions of this receptor are disputed. Initially discovered in 1998 as an Orphan receptor, i.e. a receptor whose activating ligand(s) and function were unknown
Fidarestat (154 words) [view diff] no match in snippet view article find links to article
Fidarestat (SNK-860) is an aldose reductase inhibitor under investigation for treatment of diabetic neuropathy. Aldose reductase inhibitor for treatment
Anaphylatoxin receptors (74 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
PSB-SB-487 (175 words) [view diff] exact match in snippet view article find links to article
PSB-SB-487 is a coumarin derivative which is an antagonist at the former orphan receptor GPR55. Unlike older GPR55 antagonists such as O-1918, PSB-SB-487
Ravulizumab (571 words) [view diff] no match in snippet view article find links to article
Ravulizumab, sold under the brand name Ultomiris, is a humanized monoclonal antibody complement inhibitor medication designed for the treatment of paroxysmal
Anakinra (1,118 words) [view diff] exact match in snippet view article find links to article
human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum. Anakinra is administered at home by subcutaneous injection. It
Tony Stark (Marvel Cinematic Universe) (8,944 words) [view diff] no match in snippet view article
Anthony Edward Stark is a fictional character portrayed by Robert Downey Jr. in the Marvel Cinematic Universe (MCU) film franchise—based on the Marvel
Pharmaceutical industry (11,495 words) [view diff] exact match in snippet view article find links to article
benefit to society. There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases
Gendry (2,297 words) [view diff] exact match in snippet view article find links to article
proudly made for himself, which earned him the nickname "Bull" by fellow orphan boy Lommy Greenhands. Gendry is not a point of view character in the novels
Methoxsalen (651 words) [view diff] no match in snippet view article find links to article
Methoxsalen (also called xanthotoxin), sold under the brand name Oxsoralen among others, is a drug used to treat psoriasis, eczema, vitiligo, and some
Goku (10,030 words) [view diff] no match in snippet view article find links to article
Son Goku is a fictional character and main protagonist of the Dragon Ball manga series created by Akira Toriyama. He is based on Sun Wukong (known as Son
Christine Daaé (1,704 words) [view diff] no match in snippet view article find links to article
Christine Daaé is a fictional character and the female protagonist of Gaston Leroux's 1910 novel The Phantom of the Opera and of the various adaptations
Sarepta Therapeutics (1,074 words) [view diff] no match in snippet view article find links to article
Sarepta Therapeutics, Inc. (Nasdaq: SRPT) is a medical research and drug development company with corporate offices and research facilities in Cambridge
Alison Steadman (1,333 words) [view diff] exact match in snippet view article find links to article
include Pride and Prejudice (1995), Gavin & Stacey (2007–2010, 2019) and Orphan Black (2015–2016). Her other film appearances include A Private Function
Hebrew Orphan Asylum (Baltimore, Maryland) (771 words) [view diff] exact match in snippet view article
The Hebrew Orphan Asylum is an historic institutional orphanage and former hospital building located in the Mosher neighborhood of Baltimore, Maryland
Prokineticin receptor 1 (514 words) [view diff] exact match in snippet view article find links to article
and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402
Raistlin Majere (7,145 words) [view diff] no match in snippet view article find links to article
Raistlin Majere is a fictional character from the Dragonlance series of books created by Margaret Weis and Tracy Hickman. Raistlin played an extensive
Alec Trevelyan (1,158 words) [view diff] no match in snippet view article find links to article
Alec Trevelyan (006), also known as Janus, is a fictional character and the main antagonist in the 1995 James Bond film GoldenEye, the first film to feature
GPR156 (358 words) [view diff] exact match in snippet view article find links to article
Watkins, Lyndsay R.; Orlandi, Cesare (2021-03-30). "In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity". British Journal
Portrayal of James Bond in film (8,092 words) [view diff] no match in snippet view article find links to article
Commander James Bond RN—code number 007—is a fictional character created by the British journalist and novelist Ian Fleming in 1952. The character appeared
List of My-HiME characters (8,321 words) [view diff] exact match in snippet view article find links to article
attack by an Orphan. Mai materializes her Elements for the first time and also acquires her Child, Kagutsuchi, which she uses to defeat the Orphan. In the
GPR39 (575 words) [view diff] exact match in snippet view article find links to article
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39". Biochem. Biophys. Res. Commun. 351 (1):
Maria Doyle Kennedy (2,665 words) [view diff] exact match in snippet view article find links to article
Tudors (2007–2010), Vera Bates in Downton Abbey (2011), Siobhán Sadler in Orphan Black (2013–2017), and Jocasta Cameron in Outlander (2018–present). Doyle
GPR116 (446 words) [view diff] exact match in snippet view article find links to article
(May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10
Time Squad (2,236 words) [view diff] exact match in snippet view article find links to article
encounter Otto Osworth (Pamela Adlon), an 8-year-old boy who happens to be an orphan from the 21st century, he is quickly recruited and added to the team. Otto
Street children (6,170 words) [view diff] exact match in snippet view article find links to article
them more willing to force their children to the streets. For example, orphans are given financial benefits, but if they live in state-run facilities
Esmeralda (The Hunchback of Notre-Dame) (1,846 words) [view diff] exact match in snippet view article
the love child of Paquette Guybertaut, nicknamed 'la Chantefleurie', an orphaned minstrel's daughter who lives in Rheims. Paquette has become a prostitute
Beth Harmon (586 words) [view diff] exact match in snippet view article find links to article
Actor in a Miniseries or Television Movie. Beth is a chess prodigy who was orphaned at age nine when her mother died in a car crash. Growing up in an orphanage
GPR45 (368 words) [view diff] exact match in snippet view article find links to article
DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
Glasdegib (689 words) [view diff] exact match in snippet view article find links to article
granted priority review and orphan drug designation by the U.S. Food and Drug Administration (FDA). It was granted orphan drug designation by the European
Aerith Gainsborough (4,679 words) [view diff] no match in snippet view article find links to article
Aerith Gainsborough (Japanese: エアリス・ゲインズブール, Hepburn: Earisu Geinzubūru), transliterated as Aeris Gainsborough in the English releases of Final Fantasy
Copyright law of the United States (9,224 words) [view diff] exact match in snippet view article find links to article
or (c) the work is not the type of work that copyright can protect. The "orphan works" problem arose in the United States with the enactment of the Copyright
ROR1 (1,094 words) [view diff] exact match in snippet view article find links to article
by the ROR1 gene. ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
Snak (760 words) [view diff] no match in snippet view article find links to article
Snak (Danish for "chat") is a shareware Internet Relay Chat (IRC) client written by Kent Sorensen for the Macintosh platform. Snak is distributed as shareware
Lumiliximab (281 words) [view diff] exact match in snippet view article find links to article
antibody that targets CD23. It acts as an immunomodulator and was awarded orphan drug status and fast track designation by the FDA. It was investigated in
Bruce Wayne (DC Extended Universe) (5,425 words) [view diff] no match in snippet view article
Bruce Wayne, also known by his vigilante alias Batman, is a fictional character in the DC Extended Universe based on the character of the same name. The
Ibrutinib (2,658 words) [view diff] no match in snippet view article find links to article
Ibrutinib, sold under the brand name Imbruvica among others, is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK)
Blue Sky Black Death (2,052 words) [view diff] exact match in snippet view article find links to article
started producing exclusively around 2000. Kingston, working under the name Orphan, began his solo producing career collaborating with rapper Noah23 and the
Little Annie Rooney (1,037 words) [view diff] exact match in snippet view article find links to article
Little Annie Rooney is a comic strip about a young orphaned girl who traveled about with her dog, Zero. King Features Syndicate launched the strip on January
Adhesion G protein-coupled receptor (3,385 words) [view diff] exact match in snippet view article find links to article
adhesion GPCRs. A majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors . Adhesion GPCRs get their
Bagheera (2,122 words) [view diff] no match in snippet view article find links to article
Bagheera is a fictional character in Rudyard Kipling's Mowgli stories in The Jungle Book (coll. 1894) and The Second Jungle Book (coll. 1895). He is a
Cobimetinib (703 words) [view diff] exact match in snippet view article find links to article
vomiting, rash, photosensitivity, and pyrexia. Cobimetinib was awarded orphan drug status by the FDA for malignant melanoma with BRAFV600 mutation in
Sodium phenylbutyrate (1,642 words) [view diff] exact match in snippet view article find links to article
excretion of excess nitrogen. It is an orphan drug, marketed by Ucyclyd Pharma under the trade name Buphenyl, by Swedish Orphan International (Sweden) as Ammonaps
Clubber Lang (737 words) [view diff] no match in snippet view article find links to article
James "Clubber" Lang is a fictional character created by Sylvester Stallone for the film Rocky III, which was released in 1982. Lang serves as the main
Neuropeptide FF receptor 2 (543 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Fedratinib (664 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for fedratinib priority review and orphan drug designations. The FDA granted the approval of Inrebic to Impact Biomedicines
Pomalidomide (979 words) [view diff] no match in snippet view article find links to article
Pomalidomide (INN; marketed as Pomalyst in the US and Imnovid in the European Union and Russia) is a derivative of thalidomide marketed by Celgene. It
Steve Rogers (Marvel Cinematic Universe) (10,136 words) [view diff] no match in snippet view article
Steven G. Rogers is a fictional character portrayed by Chris Evans in the Marvel Cinematic Universe (MCU) film franchise—based on the Marvel Comics character
Jimmy Bennett (762 words) [view diff] exact match in snippet view article find links to article
Daddy Day Care, Hostage, The Amityville Horror, Poseidon, Evan Almighty, Orphan, Shorts, and as young James T. Kirk in the 2009 film Star Trek. He also
ACKR3 (1,076 words) [view diff] exact match in snippet view article find links to article
receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the
Bruce Wayne (Dark Knight trilogy) (5,489 words) [view diff] exact match in snippet view article
deduced his secret identity as Batman and can relate to him; Blake is also an orphan and has learned to hide his anger. He asks Bruce to return as Batman. Against
GPR34 (648 words) [view diff] exact match in snippet view article find links to article
Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
Arya Stark (4,772 words) [view diff] no match in snippet view article find links to article
Arya Stark is a fictional character in American author George R. R. Martin's A Song of Ice and Fire epic fantasy novel series, and its television adaptation
Canadian Screen Award for Best Dramatic Series (121 words) [view diff] exact match in snippet view article find links to article
Arctic Air Bomb Girls Continuum King 2013 Orphan Black Blackstone Bomb Girls Flashpoint Motive 2014 Orphan Black 19-2 Continuum Motive Remedy 2015 19-2
Peter Outerbridge (362 words) [view diff] exact match in snippet view article find links to article
David Sandström in the TMN series ReGenesis, Henrik "Hank" Johanssen in Orphan Black, Bob Corbett in Bomb Girls, William Easton in Saw VI, George Brown
Lorlatinib (930 words) [view diff] exact match in snippet view article find links to article
positive advanced non-small-cell lung cancer. In 2015, FDA granted Pfizer orphan drug status for lorlatinib for the treatment of NSCLC. In 2018, the FDA
John Watts (New York politician) (1,219 words) [view diff] exact match in snippet view article
New York from 1802 to 1807. In 1831, Watts organized the Leake and Watts Orphan Asylum after his friend (who was also his sister Margaret's brother-in-law)
Genzyme (1,948 words) [view diff] exact match in snippet view article find links to article
world’s population. Drugs used to treat such conditions are considered to be orphan drugs. Ceredase was the first effective treatment for Gaucher's disease
Beechholme (269 words) [view diff] no match in snippet view article find links to article
Beechholme was a children's home in Fir Tree Road, Banstead, Surrey. It was founded in 1879 as a Residential School for poor children from the slums of
TinEye (1,144 words) [view diff] exact match in snippet view article find links to article
looking to make use of imagery under orphan works to find the copyright holders of that imagery. Being that orphan works can be defined as "copyrighted
Buprenorphine/naloxone (3,238 words) [view diff] no match in snippet view article find links to article
Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone
Tomorrow (Annie) (1,116 words) [view diff] exact match in snippet view article
Charnin and Thomas Meehan began working on a musical based on the Little Orphan Annie comic strips, Annie. Strouse contributed a reworked version of "Replay"
Comic strip (6,314 words) [view diff] exact match in snippet view article find links to article
Alley Oop (1932–present) Bringing Up Father (1913–2000; 87 years) Little Orphan Annie (1924–2010; 86 years) Most newspaper comic strips are syndicated;
Ontuxizumab (162 words) [view diff] exact match in snippet view article find links to article
endosialin (TEM1 or CD248). Phase I trials are complete and the drug was granted orphan drug status by the FDA for sarcoma. It is currently in phase II trials for
Bayer (10,478 words) [view diff] no match in snippet view article find links to article
Bayer AG (/ˈbeɪ.ər, ˈbaɪ.ər/; German: [ˈbaɪɐ]) is a German multinational pharmaceutical and life sciences company and one of the largest pharmaceutical
Plerixafor (1,544 words) [view diff] exact match in snippet view article find links to article
Further studies led to the new indication for cancer patients. Plerixafor has orphan drug status in the United States and European Union for the mobilization
National Cartoonists Society (3,958 words) [view diff] exact match in snippet view article find links to article
both The Orphan Works Act of 2008 and the Shawn Bentley Orphan Works Act of 2008. Known collectively as "Artists United Against the U.S. Orphan Works Acts"
Boba Fett (9,419 words) [view diff] no match in snippet view article find links to article
Boba Fett (/ˌboʊbə ˈfɛt, ˌbɒ-/) is a fictional character in the Star Wars franchise created by George Lucas. He is an armored bounty hunter featured in
Veltuzumab (283 words) [view diff] exact match in snippet view article find links to article
was originally known as IMMU-106. In August 2015 the US FDA granted it orphan drug status for immune thrombocytopenia (ITP). A phase II trial is planned
Dark Castle Entertainment (471 words) [view diff] exact match in snippet view article find links to article
Reaping (2007) The Reaping DVD (2007) RocknRolla (2008) RocknRolla DVD (2008) Orphan (2009) Whiteout (2009) Whiteout DVD (2009) Ninja Assassin(2009) Ninja Assassin
Lorvotuzumab mertansine (178 words) [view diff] exact match in snippet view article find links to article
cancers (e.g. small-cell lung cancer, ovarian cancer). It has been granted Orphan drug status for Merkel cell carcinoma. It has reported encouraging Phase
21st Genie Awards (65 words) [view diff] exact match in snippet view article find links to article
Maelström Alain DesRochers, The Bottle (La Bouteille) Robert Favreau, The Orphan Muses (Les Muses orphelines) Robert Lepage, Possible Worlds Gary Burns,
Satellite Award for Best Actress – Television Series Drama (24 words) [view diff] exact match in snippet view article find links to article
Ellie Miller Vera Farmiga Bates Motel Norma Louise Bates Tatiana Maslany Orphan Black Various Characters Anne Reid Last Tango in Halifax Celia Dawson Keri
Claude Frollo (2,486 words) [view diff] exact match in snippet view article find links to article
Dame. Dom Claude Frollo is a pious and highly knowledgeable man who was orphaned along with his younger brother Jehan when their parents died of the plague
St. Patrick's Old Cathedral School (483 words) [view diff] exact match in snippet view article find links to article
which the school occupied was built in 1825–1826 for the Roman Catholic Orphan Asylum, which had been founded in 1822 in a wooden building on the same
Pexidartinib (637 words) [view diff] exact match in snippet view article find links to article
granted the application for pexidartinib breakthrough therapy designation, orphan drug designation, and priority review designation. The FDA granted the approval
Leukotriene B4 receptor (27 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Bevacizumab (6,469 words) [view diff] no match in snippet view article find links to article
Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer it is
Oprozomib (277 words) [view diff] exact match in snippet view article find links to article
against bortezomib-resistant multiple myeloma cells. Oprozomib was granted orphan drug status for the treatment of Waldenström's macroglobulinaemia and multiple
Paddington Bear (6,229 words) [view diff] exact match in snippet view article find links to article
information about his past. For instance, one story reveals that Paddington was orphaned in an earthquake, before being taken in and raised by his Aunt Lucy. There
Baby Buggy Bunny (762 words) [view diff] exact match in snippet view article find links to article
ill-gotten gains down Bugs' rabbit hole, forcing him to don the disguise of an orphan baby to get it back. Baby-Face Finster (a.k.a. Ant Hill Harry), a 35-year-old
Starkiller (3,612 words) [view diff] no match in snippet view article find links to article
Starkiller, born Galen Marek and also known as The Apprentice, is the fictional protagonist of the Star Wars: The Force Unleashed video games and literature
Brenda Brave Helps Grandmother (287 words) [view diff] no match in snippet view article find links to article
Brenda Brave Helps Grandmother (original title: Kajsa Kavat) is a story by Astrid Lindgren about a young girl named Brenda (Kajsa) in Sweden. The book
Orihime Inoue (2,579 words) [view diff] no match in snippet view article find links to article
Orihime Inoue (Japanese: 井上 織姫, Hepburn: Inoue Orihime) is a fictional character and in the Bleach manga series and its adaptations created by Tite Kubo
Logan (film series character) (6,695 words) [view diff] no match in snippet view article
James "Logan" Howlett, better known by his codename, Wolverine, is a fictional character from 20th Century Fox's superhero film series X-Men, portrayed
Orphan of Lowood (264 words) [view diff] exact match in snippet view article find links to article
Orphan of Lowood (German: Die Waise von Lowood) is a 1926 German silent drama film directed by Curtis Bernhardt and starring Evelyn Holt, Olaf Fønss and
Ajulemic acid (338 words) [view diff] exact match in snippet view article find links to article
Corbus Pharmaceuticals (formerly JB Therapeutics) for the treatment of orphan chronic life-threatening inflammatory diseases.[citation needed] Burstein
Sunday comics (2,210 words) [view diff] exact match in snippet view article find links to article
comic strips appear both daily and Sunday, in some cases, as with Little Orphan Annie, telling the same story daily and Sunday, in other cases, as with
Rima (1,234 words) [view diff] no match in snippet view article find links to article
Rima, also known as Rima the Jungle Girl, is the fictional heroine of W. H. Hudson's 1904 novel Green Mansions: A Romance of the Tropical Forest. In it
Second Doctor (2,573 words) [view diff] exact match in snippet view article find links to article
returned home, the Doctor and Jamie would at first be joined by the Victorian orphan Victoria Waterfield (Deborah Watling) and then by the 21st century astrophysicist
Hydroxycarboxylic acid receptor 1 (515 words) [view diff] exact match in snippet view article find links to article
2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". The Journal of Biological Chemistry
BD Wong (1,622 words) [view diff] exact match in snippet view article find links to article
starred in the U.S. premiere of James Fenton's acclaimed adaptation of The Orphan of Zhao, a classic Chinese legend that has its roots in the fourth century
Bombesin receptor (65 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Formyl peptide receptor 3 (2,228 words) [view diff] exact match in snippet view article find links to article
receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10
Iratumumab (83 words) [view diff] exact match in snippet view article find links to article
Medarex, which was later acquired by Bristol-Myers Squibb. The FDA granted orphan drug designation for Hodgkin's lymphoma in 2004. In 2009, development was
Tafasitamab (464 words) [view diff] no match in snippet view article find links to article
Tafasitamab, sold under the brand name Monjuvi, is a medication used in combination with lenalidomide for the treatment of adults with relapsed or refractory
L'Orphelin de la Chine (593 words) [view diff] exact match in snippet view article find links to article
L'Orphelin de la Chine (The Orphan of China) is a 1753 French play by Voltaire based on The Orphan of Zhao, a thirteenth-century Chinese play attributed
The Royal Alexandra and Albert School (758 words) [view diff] exact match in snippet view article find links to article
Royal Alexandra School, which was founded in 1758, and The Royal Albert orphan School, which was founded in 1864 as a national memorial to Prince Albert
Lucina (Fire Emblem) (1,747 words) [view diff] no match in snippet view article
Lucina (Japanese: ルキナ, Hepburn: Rukina) is a fictional character and one of the protagonists from Intelligent Systems's 2012 role-playing video game Fire
Fena: Pirate Princess (278 words) [view diff] exact match in snippet view article find links to article
published by Crunchyroll: Fena: Pirate Princess tells the tale of a young orphan girl, Fena Houtman, living in a fantastic alternate history version of the
Belinostat (347 words) [view diff] exact match in snippet view article find links to article
trial for T-cell lymphoma were encouraging. Belinostat has been granted orphan drug and fast track designation by the FDA, and was approved in the US for