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searching for Orphan 529 found (96329 total)

alternate case: orphan

Tatiana Maslany (3,546 words) [view diff] exact match in snippet view article find links to article

playing multiple characters in the science fiction thriller television series Orphan Black (2013–2017), which won her a Primetime Emmy Award (2016), two Critics'
Orphan Black (8,276 words) [view diff] exact match in snippet view article find links to article
Orphan Black is a Canadian science-fiction thriller television series created by screenwriter Graeme Manson and director John Fawcett and starring Tatiana
Orphan: First Kill (3,063 words) [view diff] exact match in snippet view article find links to article
Orphan: First Kill is a 2022 psychological horror-thriller film that serves as a prequel to the 2009 film Orphan. Directed by William Brent Bell, it was
Orphan (2009 film) (2,321 words) [view diff] exact match in snippet view article
Orphan is a 2009 psychological horror-thriller film directed by Jaume Collet-Serra and written by David Leslie Johnson from a story by Alex Mace. The film
Isabelle Fuhrman (1,442 words) [view diff] exact match in snippet view article find links to article
She is known for her role as Esther in the horror film Orphan (2009) and its prequel Orphan: First Kill (2022), which has led some publications to label
Orphan drug (4,107 words) [view diff] exact match in snippet view article find links to article
An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without
Diageo (2,900 words) [view diff] no match in snippet view article find links to article
Diageo plc (/diˈædʒioʊ/) is a multinational alcoholic beverage company, with its headquarters in London, England. It operates from 132 sites around the
Rogue planet (3,397 words) [view diff] exact match in snippet view article find links to article
planet (also termed a free-floating planet (FFP), interstellar, nomad, orphan, sunless, starless, unbound or wandering planet) is an interstellar object
Acronym (14,247 words) [view diff] exact match in snippet view article find links to article
"K9" (kay-nine) for "canine". Pseudo-acronyms also frequently develop as "orphan initialisms"; an existing acronym is redefined as a non-acronymous name
Rare disease (2,083 words) [view diff] exact match in snippet view article find links to article
affects a small percentage of the population. In some parts of the world, an orphan disease is a rare disease whose rarity means there is a lack of a market
Annie (musical) (7,487 words) [view diff] exact match in snippet view article
Broadway musical based upon the popular Harold Gray comic strip Little Orphan Annie and loosely based on the 1885 poem "Little Orphant Annie" written
Little Orphan Annie (7,133 words) [view diff] exact match in snippet view article find links to article
Little Orphan Annie is a daily American comic strip created by Harold Gray and syndicated by the Tribune Media Services. The strip took its name from the
RAR-related orphan receptor gamma (2,318 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of
RAR-related orphan receptor beta (1,030 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans
RAR-related orphan receptor (1,111 words) [view diff] exact match in snippet view article find links to article
The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR
European Medicines Agency (2,556 words) [view diff] exact match in snippet view article find links to article
CHMP as described above. The Committee on Orphan Medicinal Products (COMP) administers the granting of orphan drug status since 2000. Companies intending
Cassandra Cain (6,195 words) [view diff] exact match in snippet view article find links to article
Batgirl. Over the years, she has also assumed the code names of Black Bat, Orphan, and in current stories, shares the Batgirl name with Stephanie Brown. Cassandra's
Orphan receptor (733 words) [view diff] exact match in snippet view article find links to article
a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan". Conversely, the term orphan ligand refers to
RAR-related orphan receptor alpha (2,661 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is
Texas Blind, Deaf, and Orphan School (556 words) [view diff] exact match in snippet view article find links to article
Texas Blind, Deaf, and Orphan School was a school for blind and deaf black people in Austin, Texas. Throughout its history, due to educational segregation
Orphan work (1,651 words) [view diff] exact match in snippet view article find links to article
An orphan work is a copyright-protected work for which rightsholders are positively indeterminate or uncontactable. Sometimes the names of the originators
Retinoic acid-inducible orphan G protein-coupled receptor (370 words) [view diff] exact match in snippet view article find links to article
The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression
Nuclear receptor 4A3 (1,321 words) [view diff] exact match in snippet view article find links to article
(nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene
Orphanet (1,158 words) [view diff] exact match in snippet view article find links to article
knowledge base dedicated to rare diseases as well as corresponding diagnosis, orphan drugs, clinical trials and expert networks The website is managed by a network
Lord Voldemort (8,265 words) [view diff] no match in snippet view article find links to article
Lord Voldemort (/ˈvoʊldəmɔːr/ VOHL-də-mor, /-mɔːrt/ -⁠mort in the films) is a sobriquet for Tom Marvolo Riddle, a character and the main antagonist in
Nuclear receptor (6,478 words) [view diff] exact match in snippet view article find links to article
target nuclear receptors. A number of nuclear receptors, referred to as orphan receptors, have no known (or at least generally agreed upon) endogenous
Jon Snow (character) (8,467 words) [view diff] exact match in snippet view article
introduced in A Game of Thrones (1996), as he and his five siblings adopt six orphaned direwolf cubs. Jon takes the runt of the litter, a white cub that he names
Oliver Twist (4,072 words) [view diff] exact match in snippet view article find links to article
1837 to 1839, and as a three-volume book in 1838. Born in a workhouse, the orphan Oliver Twist is sold into apprenticeship with an undertaker. After escaping
Tom Sawyer (519 words) [view diff] no match in snippet view article find links to article
Thomas Sawyer (/ˈsɔːjər/) is the titular character of the Mark Twain novel The Adventures of Tom Sawyer (1876). He appears in three other novels by Twain:
Small heterodimer partner (1,773 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
Orphan wells (1,931 words) [view diff] exact match in snippet view article find links to article
Orphan, orphaned or abandoned wells are oil or gas wells that have been abandoned by fossil fuel extraction industries. These wells may have been deactivated
Johns Hopkins (4,281 words) [view diff] exact match in snippet view article find links to article
female orphans principally as domestic workers, and next as an "orthopedic convalescent" home and school for "colored crippled" children and orphans. The
X-Statix (2,353 words) [view diff] exact match in snippet view article find links to article
Allred. The storyline (which features the returns of the Anarchist, the Orphan, and U-Go Girl) parodies the manner in which creators in the industry handle
Green Hornet (4,197 words) [view diff] exact match in snippet view article find links to article
Team Venture. It is also revealed that Blue Morpho was the father of the orphaned villain The Monarch, and he and Henchman 21 later take on the roles of
Widows and orphans (779 words) [view diff] exact match in snippet view article find links to article
In typesetting, widows and orphans are lines at the beginning or end of a paragraph that are left dangling at the top or bottom of a page or column, separated
Wanda Maximoff (Marvel Cinematic Universe) (8,224 words) [view diff] no match in snippet view article
Wanda Maximoff is a fictional character primarily portrayed by Elizabeth Olsen in the Marvel Cinematic Universe (MCU) media franchise based on the Marvel
Reed's School (1,625 words) [view diff] exact match in snippet view article find links to article
Kingdom. The foundation was established to provide relief to destitute orphans, including children whose fathers had died and whose mothers were unable
Midway University (1,495 words) [view diff] exact match in snippet view article find links to article
undergraduate students. Midway University originally opened as the Kentucky Female Orphan School on October 3, 1849, with one teacher and sixteen female students
Daenerys Targaryen (10,249 words) [view diff] no match in snippet view article find links to article
Daenerys Targaryen (/dəˈnɛərɪs tɑːrˈɡɛəriən/ də-NAIR-iss tar-GAIR-ee-ən) is a fictional character in the series of epic fantasy novels A Song of Ice and
Testicular receptor 2 (925 words) [view diff] exact match in snippet view article find links to article
1016/S0006-291X(89)80028-2. PMID 2597158. Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate
Orphan Girl at the Cemetery (331 words) [view diff] exact match in snippet view article find links to article
The Orphan Girl at the cemetery (also known as Young Orphan Girl in the Cemetery; French: Jeune orpheline au cimetière) (c. 1823 or 1824) is a painting
Depatuxizumab mafodotin (261 words) [view diff] exact match in snippet view article find links to article
Depatux-M after late-stage failure in newly diagnosed glioblastoma. In 2014, Orphan Drug Status was granted by the FDA for glioblastoma multiforme. It is in
Sodium oxybate (4,129 words) [view diff] exact match in snippet view article find links to article
approved for treating symptoms of narcolepsy in the European Union in 2005. Orphan Medical had developed it and was acquired by Jazz Pharmaceuticals in 2005
AstraZeneca (7,036 words) [view diff] exact match in snippet view article find links to article
would partner with Orca Pharmaceuticals to develop retinoic acid-related orphan nuclear receptor gamma inhibitors for use in the treatment of a number of
Kato (The Green Hornet) (3,239 words) [view diff] no match in snippet view article
Kato is a fictional character from The Green Hornet franchise. This character has appeared with the Green Hornet in radio, film, television, book and comic
Burosumab (839 words) [view diff] exact match in snippet view article find links to article
April 2018. The FDA approval fell under both the breakthrough therapy and orphan drug designations. It was approved for use in the European Union in February
Benralizumab (250 words) [view diff] exact match in snippet view article find links to article
treatment of severe eosinophilic asthma. It was granted designation as an orphan drug by the Food and Drug Administration for treatment of eosinophilic oesophagitis
Hydrocortisone (1,204 words) [view diff] no match in snippet view article find links to article
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital
Amifampridine (3,148 words) [view diff] exact match in snippet view article find links to article
Amifampridine phosphate has orphan drug status in the EU for Lambert–Eaton myasthenic syndrome and Catalyst holds both an orphan designation and a breakthrough
Testicular receptor 4 (1,135 words) [view diff] exact match in snippet view article find links to article
Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings
Eculizumab (3,143 words) [view diff] exact match in snippet view article find links to article
tax incentives in the Orphan Drug Act of 1983. On average the cost per person for orphan drugs is "six times that of non-orphan drugs, a clear indication
Nuclear receptor 4A1 (2,518 words) [view diff] exact match in snippet view article find links to article
homodimer to NurRE. It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription
Solriamfetol (1,118 words) [view diff] exact match in snippet view article find links to article
adults with narcolepsy or obstructive sleep apnea (OSA). It was granted orphan drug designation. The U.S. Food and Drug Administration (FDA) approved solriamfetol
Sotalol (1,506 words) [view diff] no match in snippet view article find links to article
Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. It is only recommended in those
Infigratinib (290 words) [view diff] exact match in snippet view article find links to article
fibroblast growth factor receptors FGFR1, FGFR2 and FGFR3 It was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2019, and it was
The Orphan Master's Son (1,705 words) [view diff] exact match in snippet view article find links to article
The Orphan Master's Son is a 2012 novel by American author Adam Johnson. It deals with intertwined themes of propaganda, identity, and state power in North
Arya Stark (5,804 words) [view diff] no match in snippet view article find links to article
Arya Stark is a fictional character in American author George R. R. Martin's A Song of Ice and Fire epic fantasy novel series, and its television adaptation
Class C GPCR (251 words) [view diff] exact match in snippet view article find links to article
(GRM5) mGluR6 (GRM6) mGluR7 (GRM7) mGluR8 (GRM8) Retinoic acid-inducible orphan G protein-coupled receptors (RAIG) RAIG1 (GPRC5A) RAIG2 (GPRC5B) RAIG3 (GPRC5C)
Rickon Stark (1,758 words) [view diff] no match in snippet view article find links to article
Rickon Stark is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Estrogen-related receptor (1,169 words) [view diff] exact match in snippet view article find links to article
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of
Itraconazole (2,316 words) [view diff] exact match in snippet view article find links to article
"Itraconazole Orphan Drug Designation". U.S. Food and Drug Administration (FDA). 19 May 2016. Retrieved 15 May 2020. "Itraconazole Orphan Drug Designation"
Gord the Rogue (2,595 words) [view diff] exact match in snippet view article find links to article
novel, Dance of Demons. The series of novels follows the progress of the orphan beggar Gord, from his lowly youth to his ascension as an avatar of Balance
Colchicine (5,289 words) [view diff] exact match in snippet view article find links to article
for Colcrys in the treatment of familial Mediterranean fever, under the Orphan Drug Law. URL Pharma then raised the price per tablet from $0.09 to $4.85
Vesper Lynd (1,934 words) [view diff] exact match in snippet view article find links to article
Vesper and Bond size each other up, and each deduce that the other is an orphan. Vesper is initially skeptical about Bond's ego and at first is unwilling
Vito Corleone (2,305 words) [view diff] exact match in snippet view article find links to article
Robert De Niro as a young man in The Godfather Part II (1974). He is an orphaned Sicilian immigrant who builds a Mafia empire. He and his wife Carmela have
COUP-TFII (1,548 words) [view diff] exact match in snippet view article find links to article
PMID 8530078. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development"
Orphan of the Pecos (697 words) [view diff] exact match in snippet view article find links to article
Orphan of the Pecos is a 1937 American Western film produced and directed by Sam Katzman and starring Tom Tyler, Jeanne Martel, Howard Bryant, and Forrest
NAGly receptor (1,143 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous
Huckleberry Finn (1,596 words) [view diff] no match in snippet view article find links to article
Huckleberry "Huck" Finn is a fictional character created by Mark Twain who first appeared in the book The Adventures of Tom Sawyer (1876) and is the protagonist
Liver receptor homolog-1 (1,327 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
Emapalumab (667 words) [view diff] exact match in snippet view article find links to article
normal catabolism. The U.S. Food and Drug Administration (FDA) granted orphan drug designations in 2010 and 2020, and breakthrough therapy designation
Stiripentol (1,101 words) [view diff] exact match in snippet view article find links to article
December 2001, the European Medicines Agency (EMA) granted stiripentol orphan drug status (designation number EU/3/01/071) for the treatment of severe
Orphan Train (5,284 words) [view diff] exact match in snippet view article find links to article
The Orphan Train Movement was a supervised welfare program that transported children from crowded Eastern cities of the United States to foster homes located
Superfund (4,988 words) [view diff] exact match in snippet view article find links to article
is allocable among PRPs in contribution based on comparative fault. An "orphan share" is the share of costs at a Superfund site that is attributable to
Ivosidenib (1,017 words) [view diff] exact match in snippet view article find links to article
several forms of cancer. The U.S. Food and Drug Administration (FDA) awarded orphan drug designation for acute myeloid leukemia and for cholangiocarcinoma.
Larotrectinib (545 words) [view diff] exact match in snippet view article find links to article
licensed to Loxo Oncology in 2013. Larotrectinib was initially awarded orphan drug status in 2015, for soft tissue sarcoma, and breakthrough therapy designation
Methotrexate (2,840 words) [view diff] no match in snippet view article find links to article
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases
Avelumab (1,441 words) [view diff] exact match in snippet view article find links to article
targets the protein programmed death-ligand 1 (PD-L1). It has received orphan drug designation by the European Medicines Agency (EMA) for the treatment
Tocilizumab (2,686 words) [view diff] no match in snippet view article find links to article
Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic
Anagrelide (875 words) [view diff] exact match in snippet view article find links to article
Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (also
Estrogen-related receptor gamma (1,257 words) [view diff] exact match in snippet view article find links to article
hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists
Sodium thiosulfate (1,376 words) [view diff] no match in snippet view article find links to article
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na2S2O3.xH2O. Typically it is available as the white or colorless pentahydrate
Picornavirales (420 words) [view diff] exact match in snippet view article find links to article
picorna- is an acronym for poliovirus, insensitivity to ether, coxsackievirus, orphan virus, rhinovirus, and ribonucleic acid. Secondly, pico-, meaning extremely
Pramiracetam (400 words) [view diff] exact match in snippet view article find links to article
Phase II trials showed mixed results; it then began to develop it as an orphan drug as an adjunct to electroconvulsive therapy for major depressive disorder
Awful Orphan (652 words) [view diff] exact match in snippet view article find links to article
Awful Orphan is a 1949 Warner Bros. Merrie Melodies cartoon, directed by Chuck Jones and written by Michael Maltese. It is a sequel to the 1947 Looney
Estrogen-related receptor alpha (2,006 words) [view diff] exact match in snippet view article find links to article
that estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor. ERRα has wide tissue distribution but it is most highly
Peeta Mellark (2,701 words) [view diff] no match in snippet view article find links to article
Peeta Mellark is a fictional character from The Hunger Games trilogy by Suzanne Collins. He is portrayed by actor Josh Hutcherson in The Hunger Games film
Ibalizumab (735 words) [view diff] exact match in snippet view article find links to article
trial for s.c. and i.m. injection dosage forms (on-going). 2014: granted orphan drug designation for HIV MDR patients by U.S. FDA. 2015: granted breakthrough
Islamic adoptional jurisprudence (855 words) [view diff] exact match in snippet view article find links to article
child who is not one's genetic child is allowed and, in the case of an orphan, even encouraged. But, according to the Islamic view, the child does not
Ibalizumab (735 words) [view diff] exact match in snippet view article find links to article
trial for s.c. and i.m. injection dosage forms (on-going). 2014: granted orphan drug designation for HIV MDR patients by U.S. FDA. 2015: granted breakthrough
Islamic adoptional jurisprudence (855 words) [view diff] exact match in snippet view article find links to article
child who is not one's genetic child is allowed and, in the case of an orphan, even encouraged. But, according to the Islamic view, the child does not
Three Orphan Kittens (1,200 words) [view diff] exact match in snippet view article find links to article
Three Orphan Kittens is a 1935 animated short film in the Silly Symphonies series produced by Walt Disney Productions. It was the winner of the 1935 Oscar
Hannibal Lecter (4,038 words) [view diff] exact match in snippet view article find links to article
from his birth into a family of the Lithuanian nobility in 1933, to being orphaned, along with his beloved younger sister Mischa, in 1944 when a Nazi Stuka
Frodo Baggins (4,377 words) [view diff] no match in snippet view article find links to article
Frodo Baggins is a fictional character in J. R. R. Tolkien's writings, and one of the protagonists in The Lord of the Rings. Frodo is a hobbit of the Shire
Itachi Uchiha (3,127 words) [view diff] no match in snippet view article find links to article
Itachi Uchiha (Japanese: うちは イタチ, Hepburn: Uchiha Itachi) is a character in the Naruto manga and anime series created by Masashi Kishimoto. Itachi is the
The Sea Beast (2022 film) (1,290 words) [view diff] exact match in snippet view article
Jared Harris, and Marianne Jean-Baptiste. It tells the story of a young orphan girl who joins a group of sea monster hunters on their search for the elusive
Sotorasib (1,162 words) [view diff] exact match in snippet view article find links to article
Food and Drug Administration (FDA) granted the application for sotorasib orphan drug, fast track, priority review, and breakthrough therapy designations
Allegations of child abductions in the 2022 Russian invasion of Ukraine (961 words) [view diff] exact match in snippet view article find links to article
Putin signed a decree that streamlined the process of giving Ukrainian orphans or those without parental care Russian citizenship. By 11 April, two-thirds
Freddy Krueger (4,961 words) [view diff] no match in snippet view article find links to article
Freddy Krueger (/ˈkruːɡər/) is a fictional character in the A Nightmare on Elm Street film series. He was created by Wes Craven and made his debut in Craven's
Bran Stark (3,139 words) [view diff] exact match in snippet view article find links to article
Rickon go into hiding. To cement his claim on Winterfell, Theon has two orphan boys killed and their bodies burned, and passes their charred corpses off
Loki (Marvel Cinematic Universe) (7,322 words) [view diff] no match in snippet view article
Loki Laufeyson, known by adoption as Loki Odinson and by his title as the God of Mischief, is a fictional character portrayed by Tom Hiddleston in the
Mitotane (745 words) [view diff] exact match in snippet view article find links to article
Mitotane has been produced by Bristol Myers Squibb but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in
MRGPRG (145 words) [view diff] exact match in snippet view article find links to article
(GPR169) is a protein that in humans is encoded by the MRGPRG gene. MRGG is an orphan G-protein coupled receptor. GRCh38: Ensembl release 89: ENSG00000182170
Tetrabenazine (971 words) [view diff] no match in snippet view article find links to article
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others
Reoviridae (1,894 words) [view diff] exact match in snippet view article find links to article
tract. The name "reo-" is an acronym for "respiratory enteric orphan" viruses. The term "orphan virus" refers to the fact that some of these viruses have
Glutamine (2,377 words) [view diff] exact match in snippet view article find links to article
extremities, back pain and chest pain. L-glutamine oral powder received orphan drug designation. The FDA granted the approval of Endari to Emmaus Medical
ELTD1 (446 words) [view diff] exact match in snippet view article find links to article
and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this
Rev-ErbA alpha (4,261 words) [view diff] exact match in snippet view article find links to article
through autoregulation and regulation by retinoic acid receptor-related orphan receptor alpha (RORɑ), another nuclear receptor transcription factor. NR1D1
Alvocidib (457 words) [view diff] exact match in snippet view article find links to article
the name) and later from Dysoxylum binectariferum. The FDA has granted orphan drug designation to alvocidib for the treatment of patients with acute myeloid
Little Orphan Airedale (236 words) [view diff] exact match in snippet view article find links to article
Little Orphan Airedale is a Warner Bros. Looney Tunes cartoon directed by Charles M. Jones and released on October 4, 1947. Its major significance is its
GPR148 (304 words) [view diff] exact match in snippet view article find links to article
G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and
Daratumumab (1,671 words) [view diff] exact match in snippet view article find links to article
breakthrough therapy drug status in 2013, for multiple myeloma. It was granted orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular
Rilonacept (409 words) [view diff] exact match in snippet view article find links to article
of human IgG1 that binds and neutralizes IL-1. Rilonacept was given an orphan drug designation by the U.S. Food and Drug Administration (FDA) and is used
Iduronidase (2,100 words) [view diff] exact match in snippet view article find links to article
enjoys orphan drug status in both the United States and the European Union, though in both its orphan drug exclusivity period has expired. (Orphan drug
GPR12 (322 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR12 gene. The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene
Lithium carbonate (2,350 words) [view diff] no match in snippet view article find links to article
Lithium carbonate is an inorganic compound, the lithium salt of carbonate with the formula Li 2CO 3. This white salt is widely used in the processing of
List of Dove Medical Press academic journals (679 words) [view diff] exact match in snippet view article find links to article
Statistics† Open Access Rheumatology: Research and Reviews Open Access Surgery Orphan Drugs: Research and Reviews† Orthopedic Research and Reviews Pathology and
Ali Baba: Dastaan-E-Kabul (1,596 words) [view diff] exact match in snippet view article find links to article
of an orphan Alibaba, from the Mamuli Gali of Kabul, and the challenges he faces while he tries to protect and take care of five other orphan children
Lombard, Illinois (2,073 words) [view diff] exact match in snippet view article find links to article
Gray's parents and the studio of Harold Gray, the originator of Little Orphan Annie cartoon strip. Harold Gray used the home's study to work on the Annie
Super Conserved Receptor Expressed in Brain (171 words) [view diff] exact match in snippet view article find links to article
ligands have yet been identified for these receptors, they are classified as orphan receptors. Receptors within the group include SREB1 (GPR27), SREB2 (GPR85)
The Orphan of Zhao (2,646 words) [view diff] exact match in snippet view article find links to article
The Orphan of Zhao is a Chinese play from the Yuan era, attributed to the 13th-century dramatist Ji Junxiang (紀君祥). The play has as its full name The Great
Often an Orphan (718 words) [view diff] exact match in snippet view article find links to article
Often an Orphan is a 1949 cartoon in the Merrie Melodies series. The cartoon was released on August 13, 1949 and stars Charlie Dog and Porky Pig. The cartoon
Elizabeth Schuyler Hamilton (4,584 words) [view diff] exact match in snippet view article find links to article
is recognized as an early American philanthropist for her work with the Orphan Asylum Society. Elizabeth was born in Albany, New York, the second daughter
Bosentan (1,121 words) [view diff] no match in snippet view article find links to article
Bosentan, sold under the brand name Tracleer and Safebo among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary
Polatuzumab vedotin (583 words) [view diff] exact match in snippet view article find links to article
vedotin-piiq breakthrough therapy designation, priority review designation, and orphan drug designation. The FDA granted the approval of Polivy to Genentech. Polatuzumab
Ganaxolone (846 words) [view diff] no match in snippet view article find links to article
Ganaxolone, sold under the brand name Ztalmy, is a medication used to treat seizures in people with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder
Boba Fett (10,164 words) [view diff] no match in snippet view article find links to article
Boba Fett (/ˌboʊbə ˈfɛt, ˌbɒ-/) is a fictional character in the Star Wars franchise. First appearing in the Star Wars Holiday Special (1978), where he
Track gauge conversion (820 words) [view diff] exact match in snippet view article find links to article
gauge conversion work, some stations and branch lines may become "gauge orphans". Trains can't operate to them until costly gauge conversion work is completed
Ambrisentan (758 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) and the European Medicines Agency (EMA), and designated an orphan drug, for the treatment of pulmonary hypertension. Ambrisentan is indicated
Losartan (3,402 words) [view diff] no match in snippet view article find links to article
Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). It is in the angiotensin receptor
Radicales51 (487 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
General German Protestant Orphans Home (149 words) [view diff] exact match in snippet view article find links to article
General German Protestant Orphans Home, also known as the Pleasant Run Children's Home , is a historic orphanage located in Indianapolis, Indiana. It
Crimebuster (Boy Comics) (605 words) [view diff] no match in snippet view article
Crimebuster (Chuck Chandler) is a fictional boy hero, appearing as the lead feature in Boy Comics in the 1940s and 1950s. Dressed in a hockey uniform and
Quasimodo (3,007 words) [view diff] exact match in snippet view article find links to article
where he is found abandoned in Notre Dame (on the foundlings' bed, where orphans and unwanted children are left to public charity) on Quasimodo Sunday,
Sansa Stark (6,940 words) [view diff] no match in snippet view article find links to article
Sansa Stark is a fictional character in the A Song of Ice and Fire series of epic fantasy novels by American author George R. R. Martin, and its television
Lenvatinib (903 words) [view diff] exact match in snippet view article find links to article
treating thyroid cancer patients started in March 2011. Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not
Amgen (4,495 words) [view diff] exact match in snippet view article find links to article
Swedish Orphan Biovitrum, in December 2008) Kineret (anakinra) for rheumatoid arthritis, exclusively licensed to Biovitrium, now Swedish Orphan Biovitrum
Nitric oxide (2,371 words) [view diff] no match in snippet view article find links to article
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO. It is one of the principal oxides of nitrogen. Nitric oxide
Neuropeptides B/W receptor 1 (1,058 words) [view diff] exact match in snippet view article find links to article
When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8, but at least three groups in
Lenvatinib (903 words) [view diff] exact match in snippet view article find links to article
treating thyroid cancer patients started in March 2011. Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not
The Rescuers (5,828 words) [view diff] exact match in snippet view article find links to article
helping abduction victims around the world. The two mice must free young orphan Penny from two treasure hunters, who intend to use her to help them obtain
Rasagiline (1,932 words) [view diff] no match in snippet view article find links to article
Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease
Rifaximin (2,235 words) [view diff] no match in snippet view article find links to article
Rifaximin, is a non-absorbable, broad spectrum antibiotic mainly used to treat travelers' diarrhea. It is based on the rifamycin antibiotics family. Since
The Little Orphan (1,252 words) [view diff] exact match in snippet view article find links to article
The Little Orphan is a 1949 American one-reel animated cartoon and the 40th Tom and Jerry cartoon, released in theaters on April 30, 1949 by Metro-Goldwyn
Pacritinib (314 words) [view diff] exact match in snippet view article find links to article
granted the application for pacritinib priority review, fast track, and orphan drug designations. Pacritinib is the International nonproprietary name (INN)
Spesolimab (175 words) [view diff] no match in snippet view article find links to article
Spesolimab, sold under the brand name Spevigo, is a monoclonal antibody medication used for the treatment of generalized pustular psoriasis (GPP). It is
5th Canadian Screen Awards (493 words) [view diff] exact match in snippet view article find links to article
ceremony, the film It's Only the End of the World and the television series Orphan Black won the most awards in film and television categories, with six and
Asparaginase (1,852 words) [view diff] exact match in snippet view article find links to article
for asparaginase erwinia chrysanthemi (recombinant)-rywn fast track and orphan drug designations. The most common use of asparaginases is as a processing
Gamora (Marvel Cinematic Universe) (2,690 words) [view diff] exact match in snippet view article
to her universe, where she resumes her travels with Stark. Gamora is an orphan from an alien world who seeks redemption for her past crimes. She was trained
2nd Canadian Screen Awards (246 words) [view diff] exact match in snippet view article find links to article
nominations, while in the television categories, the science fiction series Orphan Black received 14 nominations. The awards ceremony were hosted by Martin
Moxetumomab pasudotox (1,433 words) [view diff] exact match in snippet view article find links to article
that CAT-8015 had started Phase III clinical trials. On 5 December 2008, orphan designation (EU/3/08/592) was granted by the European Commission to Medimmune
GPR15 (1,485 words) [view diff] exact match in snippet view article find links to article
protein that in humans is encoded by the GPR15 gene. GPR15 is a class A orphan G protein-coupled receptor (heterotrimeric guanine nucleotide-binding protein
Teprotumumab (1,073 words) [view diff] exact match in snippet view article find links to article
Phase I for diabetic macular edema. It was granted Breakthrough Therapy, Orphan Drug Status and Fast Track designations by the FDA for Graves' ophthalmopathy
GPRC5A (848 words) [view diff] exact match in snippet view article find links to article
dysregulated in many human cancers and in other diseases. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000013588 -
Duvelisib (1,304 words) [view diff] exact match in snippet view article find links to article
million payment for an FDA approval, and royalties. Duvelisib received orphan drug designation in the United States for the treatment of peripheral T-cell
Break of gauge (5,688 words) [view diff] exact match in snippet view article find links to article
new gauge. These severed branches can be called gauge orphans. The opposite of a gauge orphan is a line of one gauge which reaches into the territory
Annie (2014 film) (4,102 words) [view diff] exact match in snippet view article
musical of the same name (which in turn is based on the comic strip Little Orphan Annie by Harold Gray). The film changes the setting from the Great Depression
AbbVie (2,836 words) [view diff] no match in snippet view article find links to article
AbbVie is an American publicly traded biopharmaceutical company founded in 2013. It originated as a spin-off of Abbott Laboratories. On October 19, 2011
Paddington Bear (8,481 words) [view diff] exact match in snippet view article find links to article
information about his past. For instance, one story reveals that Paddington was orphaned in an earthquake, before being taken in and raised by his Aunt Lucy. There
Arylsulfatase B (1,820 words) [view diff] exact match in snippet view article find links to article
Galsulfase (N-acetylgalactosamine-4-sulfatase, recombinant human) was granted orphan drug designation by both the European Commission and the U.S. Food and Drug
Genentech (3,101 words) [view diff] no match in snippet view article find links to article
Genentech, Inc., is an American biotechnology corporation which became a subsidiary of Roche in 2009. Genentech Research and Early Development operates
Entrectinib (2,076 words) [view diff] exact match in snippet view article find links to article
S., entrectinib has orphan drug designation and rare pediatric disease designation for the treatment of neuroblastoma and orphan drug designation for
Abandonware (8,318 words) [view diff] exact match in snippet view article find links to article
abandonware is a software (or hardware) sub-case of the general concept of orphan works. Museums and various organizations dedicated to preserving this software
Istiratumab (78 words) [view diff] exact match in snippet view article find links to article
ErbB3. It is in development by Merrimack Pharmaceuticals and was awarded orphan drug status for pancreatic cancer. Alternative Names: MM-141. "Istiratumab
Durvalumab (1,677 words) [view diff] no match in snippet view article find links to article
Durvalumab (trade name Imfinzi) is an FDA-approved immunotherapy for cancer, developed by Medimmune/AstraZeneca. It is a human immunoglobulin G1 kappa
GPRC5C (651 words) [view diff] exact match in snippet view article find links to article
different isoforms have been found for this gene. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000170412 -
Entinostat (108 words) [view diff] no match in snippet view article find links to article
Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers
Avapritinib (1,035 words) [view diff] exact match in snippet view article find links to article
was granted fast track designation, breakthrough therapy designation, and orphan drug designation. The FDA granted approval of Ayvakit to Blueprint Medicines
Ripretinib (1,117 words) [view diff] exact match in snippet view article find links to article
fast track designations, as well as breakthrough therapy designation and orphan drug designation. The FDA granted approval of Qinlock to Deciphera Pharmaceuticals
GPR50 (770 words) [view diff] exact match in snippet view article find links to article
MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through
Dacomitinib (294 words) [view diff] no match in snippet view article find links to article
Dacomitinib, sold under the brand name Vizimpro, is a medication for the treatment of non-small-cell lung carcinoma (NSCLC). It is a selective and irreversible
Cabozantinib (1,705 words) [view diff] exact match in snippet view article find links to article
KIT), and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib was granted orphan drug status by the U.S. Food and Drug Administration (FDA) in November 2010
Mowgli (2,557 words) [view diff] no match in snippet view article find links to article
Mowgli (/ˈmaʊɡli/) is a fictional character and the protagonist of Rudyard Kipling's The Jungle Book stories. He is a feral boy from the Pench area in
Appian Way Productions (3,008 words) [view diff] exact match in snippet view article find links to article
Clooney’s Golden Globe nominated The Ides of March, the psychological thriller Orphan and the film adaptation of Dennis Lehane’s critically acclaimed novel Live
Retigabine (1,821 words) [view diff] exact match in snippet view article find links to article
PMC 2587091. PMID 18590620. Ben-Menachem E (2007). "Retigabine: Has the Orphan Found a Home?". Epilepsy Currents. 7 (6): 153–4. doi:10.1111/j.1535-7511
Elesclomol (662 words) [view diff] exact match in snippet view article find links to article
GlaxoSmithKline as a chemotherapy adjuvant, and has received both fast track and orphan drug status from the U.S. Food and Drug Administration for the treatment
Vorinostat (1,191 words) [view diff] no match in snippet view article find links to article
Vorinostat (rINN) also known as Suberoylanilide hydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of
Han Solo (5,059 words) [view diff] exact match in snippet view article find links to article
Alden Ehrenreich. In the film, 19-year old Han is characterized to be an orphan on the planet Corellia. He and his lover, Qi'ra (Emilia Clarke), attempt
Romiplostim (568 words) [view diff] exact match in snippet view article find links to article
(immune) thrombocytopenic purpura (ITP). Romiplostim was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2003, as the chronic
Armenian Orphan Rug (2,010 words) [view diff] exact match in snippet view article find links to article
The Armenian Orphan Rug, also known as the Ghazir Orphans' Rug, is an Armenian styled carpet woven by orphans of the Armenian genocide in Ghazir, Lebanon
The Devil's Hands Are Idle Playthings (1,318 words) [view diff] no match in snippet view article find links to article
"The Devil's Hands Are Idle Playthings" is the final episode in the fourth season of the American animated television series Futurama, and the finale of
Terguride (506 words) [view diff] exact match in snippet view article find links to article
attenuation of disease progression. In May 2008, terguride was granted orphan drug status for the treatment of pulmonary arterial hypertension. In May
Thiotepa (630 words) [view diff] exact match in snippet view article find links to article
29, 2007, the European Medicines Agency (EMA) designated thiotepa as an orphan drug. On April 2, 2007, the United States FDA designated thiotepa as a conditioning
Lyra Belacqua (1,477 words) [view diff] no match in snippet view article find links to article
Lyra Belacqua (/ˈlaɪrə bəˈlɑːkwə/), also known as Lyra Silvertongue, is the heroine of Philip Pullman's trilogy His Dark Materials. In His Dark Materials
Evinacumab (560 words) [view diff] exact match in snippet view article find links to article
Food and Drug Administration (FDA) granted the application for evinacumab orphan drug, breakthrough therapy, and priority review designations. The FDA granted
Altretamine (527 words) [view diff] no match in snippet view article find links to article
Altretamine (trade name Hexalen), also called hexamethylmelamine, is an antineoplastic agent. It was approved by the U.S. FDA in 1990. It is indicated
Nami (One Piece) (3,245 words) [view diff] exact match in snippet view article
learns of Nami's past from her adoptive sister Nojiko: Nami and Nojiko were orphaned infants rescued from a war-torn kingdom and adopted by the Marine Bellemere
Honey Ryder (1,141 words) [view diff] exact match in snippet view article find links to article
shell diver, descended from an old-established colonial family. She was orphaned at the age of five when her parents' house was burnt down. She then lived
Vertex Pharmaceuticals (3,187 words) [view diff] exact match in snippet view article find links to article
ViaCyte, Inc. for $320 million. In 2012 ivacaftor was designated as an orphan drug, identifying cystic fibrosis as affecting fewer than 200,000 people
Ixazomib (1,626 words) [view diff] exact match in snippet view article find links to article
can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative. The
GPRC5B (348 words) [view diff] exact match in snippet view article find links to article
acid on the G protein signal transduction cascade. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000167191 -
Mogamulizumab (627 words) [view diff] no match in snippet view article find links to article
Mogamulizumab, sold under the brand name Poteligeo, is a humanized, afucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4). The U.S
Altretamine (527 words) [view diff] no match in snippet view article find links to article
Altretamine (trade name Hexalen), also called hexamethylmelamine, is an antineoplastic agent. It was approved by the U.S. FDA in 1990. It is indicated
Han Solo (5,059 words) [view diff] exact match in snippet view article find links to article
Alden Ehrenreich. In the film, 19-year old Han is characterized to be an orphan on the planet Corellia. He and his lover, Qi'ra (Emilia Clarke), attempt
Doxorubicin (4,260 words) [view diff] exact match in snippet view article find links to article
program at the National Cancer Institute (NCI). In 2016 GPX-150 was granted orphan drug designation by US FDA. On 24 March 2022, the Committee for Medicinal
Constitutive androstane receptor (2,229 words) [view diff] exact match in snippet view article find links to article
Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD (Mar 1994). "A new orphan member of the nuclear hormone receptor superfamily that interacts with a
Belantamab mafodotin (709 words) [view diff] exact match in snippet view article find links to article
(FDA) granted the application for belantamab mafodotin priority review, orphan drug designation, and breakthrough therapy designation. Belantamab mafodotin
Brain Powerd (2,333 words) [view diff] exact match in snippet view article find links to article
discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies"
Acalabrutinib (1,069 words) [view diff] exact match in snippet view article find links to article
and was similarly designated as an orphan medicinal product by the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP) for treatment
Trabectedin (1,525 words) [view diff] exact match in snippet view article find links to article
European Commission and the U.S. Food and Drug Administration (FDA) granted orphan drug status to trabectedin for soft-tissue sarcomas and ovarian cancer.
Neuromedin U receptor 1 (440 words) [view diff] exact match in snippet view article find links to article
(Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and
Charlie Dog (917 words) [view diff] exact match in snippet view article find links to article
two more Charlie Dog/Porky Pig cartoons in 1949: Awful Orphan (29 January) and Often an Orphan (13 August). Jones also starred Charlie without Porky in
Chugai Pharmaceutical Co. (622 words) [view diff] exact match in snippet view article find links to article
launched 2020 – FDA approved satralizumab (Enspryng) for treatment of the orphan disease neuromyelitis optica Biotech and pharmaceutical companies in the
Posaconazole (760 words) [view diff] no match in snippet view article find links to article
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication. It was approved for medical use in the United States
Fasudil (1,176 words) [view diff] no match in snippet view article find links to article
Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which
Tremelimumab (728 words) [view diff] exact match in snippet view article find links to article
Response Criteria (irRC) instead. Although it was designated in April 2015 as orphan drug status in mesothelioma, tremelimumab failed to improve lifespan in
Tucatinib (1,462 words) [view diff] exact match in snippet view article find links to article
application for tucatinib priority review, breakthrough therapy, fast track, and orphan drug designations. The FDA granted approval of Tukysa to Seattle Genetics
Brain-specific angiogenesis inhibitor 3 (525 words) [view diff] exact match in snippet view article find links to article
growth and branching in cultured neurons. The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI
Axicabtagene ciloleucel (827 words) [view diff] exact match in snippet view article find links to article
primary mediastinal B-cell lymphoma. It also received priority review and orphan drug designation. Based on the ZUMA-1 trial, Kite submitted a biologics
Gemtuzumab ozogamicin (1,231 words) [view diff] no match in snippet view article find links to article
Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute
Link rot (1,787 words) [view diff] exact match in snippet view article find links to article
points to its target, often called a broken or dead link (or sometimes orphan link), is a specific form of dangling pointer. The rate of link rot is a
Fenfluramine (2,938 words) [view diff] exact match in snippet view article find links to article
"Fenfluramine Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 25 June 2020. "Fenfluramine Orphan Drug
Bruce Wayne (Gotham) (2,750 words) [view diff] exact match in snippet view article
finale (with Mazouz providing the character's voice). Bruce Wayne is the orphaned son of Thomas and Martha Wayne, who are murdered at the beginning of the
Leonard Starr (1,197 words) [view diff] exact match in snippet view article find links to article
known for creating the newspaper comic strip On Stage and reviving Little Orphan Annie. Born October 28, 1925, in New York City, Starr graduated from Manhattan's
Orphan School Creek (Fairfield) (199 words) [view diff] exact match in snippet view article
Orphan School Creek is a tributary of Prospect Creek, located entirely within the City of Fairfield. It starts in Allambie Road Reserve, Bossley Park,
Tom and Jerry filmography (935 words) [view diff] exact match in snippet view article find links to article
face to trick him into thinking he's caught the measles. 40 191 The Little Orphan April 30, 1949 In this Thanksgiving short, Jerry and Nibbles dine on Thanksgiving
Tolvaptan (721 words) [view diff] exact match in snippet view article find links to article
the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant
The Willoughbys (1,855 words) [view diff] exact match in snippet view article find links to article
music. Tim longs for his family's past glory and unity. Jane discovers an orphaned baby on the family's doorstep. She brings the baby inside despite Tim's
Pitolisant (823 words) [view diff] exact match in snippet view article find links to article
U.S. Food and Drug Administration (FDA) in August 2019. It was granted orphan drug designation for the treatment of narcolepsy, fast track designation
Umbralisib (1,083 words) [view diff] exact match in snippet view article find links to article
"Orphan Treatment of extranodal marginal zone lymphoma". U.S. Food and Drug Administration (FDA). 11 April 2019. Retrieved 5 February 2021. "Orphan Treatment
GPR182 (1,012 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. When this gene was first cloned, it was proposed
Inuktitut Braille (759 words) [view diff] exact match in snippet view article find links to article
Commonwealth Braille and Talking Book Cooperative. The book ᐃᓕᐊᕐᔪᒃ ᓇᓄᕐᓗ The Orphan and the Polar Bear was the first (and perhaps only) work transliterated
Oswald Cobblepot (Batman Returns) (2,101 words) [view diff] no match in snippet view article
Oswald Cobblepot, also known as the Penguin, is a fictional character in the 1992 film Batman Returns, directed by Tim Burton. Portrayed by Danny DeVito
Brigatinib (680 words) [view diff] exact match in snippet view article find links to article
application to the US FDA on August 29, 2016. In 2016, brigatinib was granted orphan drug status by the FDA for treatment of NSCLC. On 28 April 2017, it was
3rd Canadian Screen Awards (206 words) [view diff] exact match in snippet view article find links to article
13 nominations, while on the television side the science fiction series Orphan Black also received 13 nominations. The awards ceremony were hosted by Andrea
Nebula (Marvel Cinematic Universe) (3,434 words) [view diff] no match in snippet view article
Nebula is a fictional character in the Marvel Cinematic Universe (MCU) media franchise, portrayed by Karen Gillan, based on the Marvel Comics character
Diflunisal (1,329 words) [view diff] no match in snippet view article find links to article
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971, as MK647, after
Carboprost (595 words) [view diff] no match in snippet view article find links to article
Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α)
Pemtumomab (159 words) [view diff] exact match in snippet view article find links to article
2009[update], it is undergoing Phase III clinical trials. It has been granted orphan drug status in Europe. Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas
Ruxolitinib (1,567 words) [view diff] no match in snippet view article find links to article
Ruxolitinib, sold under the brand names Jakafi and Jakavi, is a medication approved in the US in 2011 for the treatment of intermediate or high-risk myelofibrosis
Enasidenib (405 words) [view diff] exact match in snippet view article find links to article
(FDA) granted the application for enasidenib fast track designation and orphan drug designation for acute myeloid leukemia in 2014. Enasidenib was approved
European Union Intellectual Property Office (1,378 words) [view diff] exact match in snippet view article find links to article
also responsible for maintaining an Orphan Works Registry. Registered works have certain permitted acts under the Orphan Works Directive. The EUIPO is based
Pimozide (934 words) [view diff] exact match in snippet view article find links to article
schizophrenia. In 1985 the pimozide was approved by the FDA for marketing as an orphan drug for the treatment of Tourette's syndrome. Medicine portal Amisulpride
Venetoclax (2,332 words) [view diff] exact match in snippet view article find links to article
and accelerated approval along with breakthrough therapy designation and orphan drug designation. Venetoclax was approved for use in the European Union
Olaparib (1,953 words) [view diff] no match in snippet view article find links to article
Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a
Monster Study (2,174 words) [view diff] exact match in snippet view article find links to article
The Monster Study was a stuttering experiment performed on 22 orphan children in Davenport, Iowa in 1939. It was conducted by Wendell Johnson at the University
Mepolizumab (1,050 words) [view diff] no match in snippet view article find links to article
Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis
Echovirus (405 words) [view diff] exact match in snippet view article find links to article
enteric disease in humans. The name is derived from "enteric cytopathic human orphan virus". These viruses were originally not associated with disease, but many
Shelleyan Orphan (780 words) [view diff] exact match in snippet view article find links to article
Shelleyan Orphan were a British alternative music group that peaked during the 1980s and early 1990s. They played a style of pop influenced by chamber
List of Drawn Together episodes (174 words) [view diff] exact match in snippet view article find links to article
Musical number: "The Board of Education" and "Fire the Load" 10 3 "Little Orphan Hero" Ray Claffey Erik Sommers Bob Bowen November 2, 2005 (2005-11-02) 203
Orion Arm (1,014 words) [view diff] exact match in snippet view article find links to article
star-forming regions) have been shown that the Local Arm appears to be an orphan segment of an arm between the Sagittarius and Perseus arms that wraps around
Nintedanib (2,687 words) [view diff] exact match in snippet view article find links to article
nintedanib group compared to the placebo group. Nintedanib was granted orphan drug designation in the US by the FDA for the treatment of idiopathic pulmonary
John Hunt Morgan (3,261 words) [view diff] no match in snippet view article find links to article
John Hunt Morgan (June 1, 1825 – September 4, 1864) was an American soldier who served as a Confederate general in the American Civil War of 1861–1865
Trastuzumab deruxtecan (1,786 words) [view diff] no match in snippet view article find links to article
Trastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin)
Rev-ErbA beta (2,030 words) [view diff] exact match in snippet view article find links to article
interaction with the transcriptional activator Retinoic Acid Receptor-related Orphan Receptor (ROR) and a direct repeat 2 element of RORE known as RevDR2. The
Jaume Collet-Serra (1,207 words) [view diff] exact match in snippet view article find links to article
producer. He is known for directing the horror films House of Wax (2005), Orphan (2009), and The Shallows (2016), as well as the Liam Neeson-led thriller
Misty (Pokémon) (1,968 words) [view diff] no match in snippet view article
Misty (original Japanese name Kasumi (カスミ)), is a fictional character in the Pokémon franchise owned by Nintendo and created by Satoshi Tajiri. She has
Chlormethine (1,694 words) [view diff] no match in snippet view article find links to article
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard
Rucaparib (1,183 words) [view diff] exact match in snippet view article find links to article
use in cases of pretreated advanced ovarian cancer. It was designated an orphan medicinal product in the European Union in October 2012. In March 2018,
GPRC5D (224 words) [view diff] exact match in snippet view article find links to article
function of this gene has not yet been determined. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000111291 -
F-15,599 (536 words) [view diff] exact match in snippet view article find links to article
gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease. F-15,599 was discovered and initially developed by Pierre Fabre
Rituximab (4,218 words) [view diff] no match in snippet view article find links to article
Rituximab, sold under the brand name Rituxan among others, is a monoclonal antibody medication used to treat certain autoimmune diseases and types of cancer
Budesonide (2,662 words) [view diff] no match in snippet view article find links to article
Budesonide, sold under the brand name Pulmicort among others, is a medication of the corticosteroid type. It is available as an inhaler, nebulization solution
GPR64 (1,155 words) [view diff] exact match in snippet view article find links to article
GPCR-Autoproteolysis INducing (GAIN) domain. The adhesion GPCR, GPR64, is an orphan receptor characterized by a long N-terminus with that has been suggested
GPR35 (1,126 words) [view diff] exact match in snippet view article find links to article
including the crypts of Lieberkühn. Although GPR35 is still considered an orphan receptor, there have been attempts to deorphanize it by identifying endogenous
Alexion Pharmaceuticals (2,198 words) [view diff] exact match in snippet view article find links to article
pharmaceutical company headquartered in Boston, Massachusetts that specializes in orphan drugs to treat rare diseases. It became a subsidiary of AstraZeneca in 2021
Sorafenib (2,625 words) [view diff] no match in snippet view article find links to article
Sorafenib, sold under the brand name Nexavar, is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma)
Nick Page (2,086 words) [view diff] exact match in snippet view article find links to article
successfully made it through screen-tests. Nick is characterised as a tough orphan who is made homeless following the death of his grandmother. Nick is also
Wedge Antilles (1,981 words) [view diff] no match in snippet view article find links to article
Wedge Antilles is a fictional character in the Star Wars franchise. He is a supporting character portrayed by Denis Lawson in the original Star Wars trilogy
Pregnane X receptor (1,963 words) [view diff] exact match in snippet view article find links to article
Watson MA, Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene
Birch bark (1,341 words) [view diff] no match in snippet view article find links to article
Birch bark or birchbark is the bark of several Eurasian and North American birch trees of the genus Betula. The strong and water-resistant cardboard-like
Novo Nordisk (2,088 words) [view diff] no match in snippet view article find links to article
Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd, Denmark, with production facilities in nine countries, and
Belzutifan (547 words) [view diff] no match in snippet view article find links to article
Belzutifan, sold under the brand name Welireg, is a medication used for the treatment of von Hippel–Lindau disease-associated renal cell carcinoma. It
Michael Mando (871 words) [view diff] exact match in snippet view article find links to article
video game franchise Far Cry (2012–2021), Vic Schmidt in the sci-fi series Orphan Black (2013–2014), and Mac Gargan in Spider-Man: Homecoming (2017). He is
Satralizumab (1,385 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for satralizumab fast track and orphan drug designations. The FDA granted the approval of Enspryng to Genentech
Receptor tyrosine kinase-like orphan receptor (85 words) [view diff] exact match in snippet view article find links to article
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in
Actelion (2,571 words) [view diff] exact match in snippet view article find links to article
Actelion focuses on the manufacture of drugs that treat rare diseases and orphan diseases. Some of the drugs it has produced have been used to treat patients
Capmatinib (1,142 words) [view diff] exact match in snippet view article find links to article
approval program and granted the application for capmatinib priority review, orphan drug, and breakthrough therapy designations and granted the approval of
Pazopanib (1,274 words) [view diff] no match in snippet view article find links to article
Pazopanib, sold under the brand name Votrient, is an anti-cancer medication marketed worldwide by Novartis. It is a potent and selective multi-targeted
Brentuximab vedotin (1,801 words) [view diff] no match in snippet view article find links to article
Brentuximab vedotin (INN; trade name Adcetris) is an antibody-drug conjugate medication used to treat relapsed or refractory Hodgkin lymphoma (HL) and
4th Canadian Screen Awards (372 words) [view diff] exact match in snippet view article find links to article
Ari Millen, Orphan Black Aaron Poole, Strange Empire Adrian Holmes, 19-2 Ben Bass, Rookie Blue Jared Keeso, 19-2 Tatiana Maslany, Orphan Black Jennie
GPR75 (312 words) [view diff] exact match in snippet view article find links to article
proteins upon the binding of a ligand. GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study
Tagraxofusp (474 words) [view diff] no match in snippet view article find links to article
Tagraxofusp, sold under the brand name Elzonris, is an anti-cancer medication for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN)
William Matthews (priest) (7,424 words) [view diff] exact match in snippet view article
and president of St. Vincent's Female Orphan Asylum and the co-founder and president of St. Joseph's Male Orphan Asylum. He was born into a prominent Maryland
Krallice (1,044 words) [view diff] exact match in snippet view article find links to article
year they released a single titled "Traditional", as well as the cover EP Orphans of Sickness. Krallice independently released their fourth full-length album
ViroPharma (769 words) [view diff] exact match in snippet view article find links to article
Makiko (11 November 2013). "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg. Pollack, Andrew (9 November 2005). "Crucial Antibiotic
Huerfano Butte (371 words) [view diff] exact match in snippet view article find links to article
Walsenburg in Huerfano County, Colorado, United States. Named Huérfano (English: orphan) by early Spanish explorers, it rises above the south side of the Huerfano
Cubone (1,334 words) [view diff] no match in snippet view article find links to article
Cubone, known in Japan as Karakara (カラカラ), is a Pokémon species in Nintendo and Game Freak's Pokémon franchise. Designed by Ken Sugimori and first introduced
Annie (1999 film) (2,286 words) [view diff] exact match in snippet view article
Martin Charnin, and Thomas Meehan, which in turn is based on the 1924 Little Orphan Annie comic strip by Harold Gray. It is the first remake and the second
Dasatinib (1,970 words) [view diff] no match in snippet view article find links to article
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia
Batman and Robin Eternal (1,127 words) [view diff] exact match in snippet view article find links to article
one of Mother's agents calling himself the Orphan. Cassandra Cain saves her, then chases after the Orphan. Dick meets Harper and her roommate Stephanie
Cromoglicic acid (1,043 words) [view diff] no match in snippet view article find links to article
Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer
Merck & Co. (8,557 words) [view diff] exact match in snippet view article find links to article
VLS-101, an antibody-drug conjugate designed to target Tyrosine kinase-like orphan receptor 1 (ROR1) in both hematological and solid tumors. VLS-101 is currently
Niraparib (1,268 words) [view diff] exact match in snippet view article find links to article
application for niraparib fast track, priority review, breakthrough therapy, and orphan drug designations. "Summary Basis of Decision (SBD) for Zejula". Health
Daddy Warbucks (1,360 words) [view diff] exact match in snippet view article find links to article
Oliver "Daddy" Warbucks is a fictional character from the comic strip Little Orphan Annie. He made his first appearance in the New York Daily News in the Annie
Biogen (3,513 words) [view diff] exact match in snippet view article find links to article
hemophilia B 2021 1993 Also approved in Canada and Australia. Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization
Selpercatinib (1,777 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for selpercatinib priority review, orphan drug, and breakthrough therapy designations; and granted approval of Retevmo
Roche (4,554 words) [view diff] no match in snippet view article find links to article
Coordinates: 47°33′31″N 7°36′22″E / 47.558624°N 7.606018°E / 47.558624; 7.606018 F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational
Niraparib (1,268 words) [view diff] exact match in snippet view article find links to article
application for niraparib fast track, priority review, breakthrough therapy, and orphan drug designations. "Summary Basis of Decision (SBD) for Zejula". Health
Jad-bal-ja (393 words) [view diff] exact match in snippet view article find links to article
Lion (1922 serial, 1923 novel), in which the ape-man discovers him as an orphaned cub and raises and trains him. He is named for the color of his coat, Jad-bal-ja
Tazemetostat (731 words) [view diff] exact match in snippet view article find links to article
The FDA granted the application for tazemetostat accelerated approval and orphan drug designation. The FDA granted the approval of Tazverik to Epizyme Inc
Mecasermin rinfabate (1,227 words) [view diff] no match in snippet view article find links to article
Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor
STI College (664 words) [view diff] exact match in snippet view article find links to article
business management and accountancy. The acronym STI has been declared as an orphan initialism after their name change in 2006. STI uses a trimester calendar
Thomas John Barnardo (1,598 words) [view diff] exact match in snippet view article find links to article
Victorian London. Many of these children were not only impoverished, but orphaned, as the result of a recent cholera outbreak. For those unable to afford
Bortezomib (2,135 words) [view diff] no match in snippet view article find links to article
Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma. This
Merck & Co. (8,557 words) [view diff] exact match in snippet view article find links to article
VLS-101, an antibody-drug conjugate designed to target Tyrosine kinase-like orphan receptor 1 (ROR1) in both hematological and solid tumors. VLS-101 is currently
Anne with an E (5,743 words) [view diff] exact match in snippet view article find links to article
was created by Moira Walley-Beckett for CBC and stars Amybeth McNulty as orphan Anne Shirley, Geraldine James as Marilla Cuthbert, R. H. Thomson as Matthew
Eltrombopag (1,049 words) [view diff] no match in snippet view article find links to article
Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe
Iloprost (1,272 words) [view diff] no match in snippet view article find links to article
Iloprost is a medication used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels
Octreotide (2,750 words) [view diff] no match in snippet view article find links to article
Octreotide, sold under the brand name Sandostatin among others, is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more
Nitisinone (858 words) [view diff] exact match in snippet view article find links to article
nitisinone being brought to market as an orphan drug Swedish Orphan International, which was later acquired by Swedish Orphan Biovitrum (Sobi).[citation needed]
Romidepsin (1,462 words) [view diff] exact match in snippet view article find links to article
designation from the FDA for the treatment of cutaneous T-cell lymphoma, and orphan drug status from the FDA and the European Medicines Agency for the same
Paromomycin (1,367 words) [view diff] no match in snippet view article find links to article
Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection.
Treprostinil (1,609 words) [view diff] exact match in snippet view article find links to article
Patient Package Insert. United Therapeutics Corp. 2013. Rare Disease and Orphan Drug Designated Approvals 2013 "Orenitram" (PDF). Full Prescribing Information
Elotuzumab (1,193 words) [view diff] no match in snippet view article find links to article
Elotuzumab, sold under the brand name Empliciti, is a humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone
Time's Orphan (887 words) [view diff] exact match in snippet view article find links to article
"Time's Orphan" is the 148th episode of the syndicated American science fiction television series Star Trek: Deep Space Nine, the 24th episode of the sixth
List of Marvel Comics characters: O (3,917 words) [view diff] no match in snippet view article find links to article
0–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Blackjack O'Hare is a fictional anthropomorphic hare in Marvel Comics. The character, created by
Carmustine (679 words) [view diff] no match in snippet view article find links to article
Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound
Adam Johnson (writer) (1,420 words) [view diff] exact match in snippet view article
and short story writer. He won the Pulitzer Prize for his 2012 novel, The Orphan Master's Son, and the National Book Award for his 2015 story collection
Trehalose (2,636 words) [view diff] no match in snippet view article find links to article
Trehalose (from Turkish tıgala – a sugar derived from insect cocoons + -ose) is a sugar consisting of two molecules of glucose. It is also known as mycose
Rydia (1,154 words) [view diff] no match in snippet view article find links to article
Rydia of Mist (ミストのリディア, Misuto no Ridia) is a fictional character in the Final Fantasy series. She appears in Final Fantasy IV as one of its protagonists
Dick Grayson (1989 film series character) (2,313 words) [view diff] no match in snippet view article
Dick Grayson, better known by his superhero alias Robin, is a fictional character from Joel Schumacher's superhero films Batman Forever (1995) and Batman
Busulfan (1,216 words) [view diff] no match in snippet view article find links to article
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific
Bombesin-like receptor 3 (823 words) [view diff] exact match in snippet view article find links to article
therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor. GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
Omacetaxine mepesuccinate (773 words) [view diff] no match in snippet view article find links to article
Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated
Naxitamab (571 words) [view diff] exact match in snippet view article find links to article
the application for naxitamab priority review, breakthrough therapy, and, orphan drug designations. The FDA issued a priority review voucher for this rare
Gendry (2,311 words) [view diff] exact match in snippet view article find links to article
proudly made for himself, which earned him the nickname "Bull" by fellow orphan boy Lommy Greenhands. Gendry is not a point of view character in the novels
Mikołaj Krzysztof "the Orphan" Radziwiłł (1,075 words) [view diff] exact match in snippet view article find links to article
Radvila Našlaitėlis) (2 Augustus 1549 – 28 February 1616) and nicknamed "the Orphan" (Polish: Sierotka, Lithuanian: Našlaitėlis), was a Polish–Lithuanian nobleman
Neuropeptide S receptor (1,698 words) [view diff] exact match in snippet view article find links to article
membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous
Michiel Huisman (1,925 words) [view diff] exact match in snippet view article find links to article
television such as Liam McGuinnis on Nashville (2012–14), Cal Morrison on Orphan Black (2014–15) and Alex Sokolov in the first season of The Flight Attendant
Matt Frewer (998 words) [view diff] exact match in snippet view article find links to article
Eureka (2006–2012) and Doctor Leekie in the Canadian science fiction drama Orphan Black (2013–2017). Frewer's more recent performances include a portrayal
Tetrahydrobiopterin (2,681 words) [view diff] no match in snippet view article find links to article
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation
Crizanlizumab (623 words) [view diff] exact match in snippet view article find links to article
crizanlizumab-tmca priority review, breakthrough therapy designation, and orphan drug designation. The FDA granted approval of Adakveo to Novartis. "AusPAR:
Sodium nitrite (4,503 words) [view diff] no match in snippet view article find links to article
Sodium nitrite is an inorganic compound with the chemical formula NaNO2. It is a white to slightly yellowish crystalline powder that is very soluble in
GPR1 (588 words) [view diff] exact match in snippet view article find links to article
PMC 2224232. PMID 18165312. Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication
GPR139 (513 words) [view diff] exact match in snippet view article find links to article
139". Dao M, Stoveken HM, Cao Y, Martemyanov KA (March 2022). "The role of orphan receptor GPR139 in neuropsychiatric behavior". Neuropsychopharmacology.
Loncastuximab tesirine (836 words) [view diff] exact match in snippet view article find links to article
response and 14% partial response). Loncastuximab tesirine was granted orphan drug designation by the U.S. Food and Drug Administration (FDA) for the
Tomorrow (Annie) (603 words) [view diff] exact match in snippet view article
Charnin and Thomas Meehan began working on a musical based on the Little Orphan Annie comic strips, Annie. Strouse contributed a reworked version of "Replay"
Seb Miller (941 words) [view diff] no match in snippet view article find links to article
Sebastian "Seb" Miller is a fictional character from the Australian soap opera Home and Away, played by Mitch Firth. He first appeared on 21 June 2001
John Fawcett (director) (479 words) [view diff] exact match in snippet view article
co-created and is a director for the award-winning BBC America television series Orphan Black. Fawcett began his career making commercials before moving on to direct
Takeda Pharmaceutical Company (2,546 words) [view diff] no match in snippet view article find links to article
The Takeda Pharmaceutical Company Limited (武田薬品工業株式会社, Takeda Yakuhin Kōgyō kabushiki gaisha) [takeꜜda jakɯçiŋ koꜜːɡʲoː] is a Japanese multinational pharmaceutical
Park County, Colorado (1,121 words) [view diff] exact match in snippet view article find links to article
been and is the location of several important mines, including the defunct Orphan Boy, which was discovered near Alma in 1861 and produced gold, silver, lead
TLX (935 words) [view diff] exact match in snippet view article find links to article
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and Cellular Biology. 20 (23): 8731–9.
Rifapentine (961 words) [view diff] exact match in snippet view article find links to article
made from rifampicin.[medical citation needed] Rifapentine was granted orphan drug designation by the FDA in June 1995, and by the European Commission
Peter Quill (Marvel Cinematic Universe) (3,430 words) [view diff] no match in snippet view article
Peter Jason Quill, also known by his alias Star-Lord, is a fictional character portrayed primarily by Chris Pratt in the Marvel Cinematic Universe (MCU)
Rifapentine (961 words) [view diff] exact match in snippet view article find links to article
made from rifampicin.[medical citation needed] Rifapentine was granted orphan drug designation by the FDA in June 1995, and by the European Commission
Tetrahydrobiopterin (2,681 words) [view diff] no match in snippet view article find links to article
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation
Harold Gray (1,229 words) [view diff] exact match in snippet view article find links to article
cartoonist, best known as the creator of the newspaper comic strip Little Orphan Annie. Harold Gray was born in Kankakee, Illinois on January 20, 1894, to
Ursodeoxycholic acid (2,464 words) [view diff] exact match in snippet view article find links to article
approved for use in the United States in December 1987, and was designated an orphan drug. "Ursodiol Use During Pregnancy". Drugs.com. 4 November 2019. Retrieved
Maria Doyle Kennedy (2,576 words) [view diff] exact match in snippet view article find links to article
Tudors (2007–2010), Vera Bates in Downton Abbey (2011), Siobhán Sadler in Orphan Black (2013–2017), and Jocasta Cameron in Outlander (2018–present). More
Runaway (dependent) (1,603 words) [view diff] no match in snippet view article
A runaway is a minor or (depending upon the local jurisdiction) a person under a specified age, who has left their parents or legal guardians without permission
Margo Martindale (1,626 words) [view diff] exact match in snippet view article find links to article
Rocketeer, ...First Do No Harm, Eye of God, Win Win, Marvin's Room, Forged, Orphan, The Savages, Hannah Montana: The Movie, August: Osage County, and Paris
Otelixizumab (693 words) [view diff] exact match in snippet view article find links to article
failed to show efficacy of the treatment. Otelixizumab has been granted "orphan drug" status by the U.S. Food and Drug Administration. As a monoclonal antibody
Ravulizumab (671 words) [view diff] no match in snippet view article find links to article
Ravulizumab, sold under the brand name Ultomiris, is a humanized monoclonal antibody complement inhibitor medication designed for the treatment of paroxysmal
Gilteritinib (448 words) [view diff] exact match in snippet view article find links to article
mutation as detected by an FDA-approved test. Gilteritinib was granted orphan drug status by the U.S. FDA, the European Commission (EC) and the Japan
Margetuximab (525 words) [view diff] exact match in snippet view article find links to article
gastric cancer and esophageal cancer.[needs update] In June 2020, it received orphan drug designation from the U.S. Food and Drug Administration (FDA). Efficacy
TLX (935 words) [view diff] exact match in snippet view article find links to article
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and Cellular Biology. 20 (23): 8731–9.
GPR55 (1,699 words) [view diff] exact match in snippet view article find links to article
a relevant role in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in oncology
Edward Cullen (3,687 words) [view diff] no match in snippet view article find links to article
Edward Cullen (né Edward Anthony Masen, Jr.) is a fictional character in Stephenie Meyer's Twilight series. He is featured in the books Twilight, New Moon
V-erbA-related gene (1,017 words) [view diff] exact match in snippet view article find links to article
Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear
Gaara (3,849 words) [view diff] no match in snippet view article find links to article
Gaara of the Desert (我愛羅) is a character in the Naruto manga and anime series created by Masashi Kishimoto. Originally debuting as an antagonist, Gaara
ROR2 (1,121 words) [view diff] exact match in snippet view article find links to article
brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
Nivolumab (4,159 words) [view diff] no match in snippet view article find links to article
Nivolumab, sold under the brand name Opdivo, is a medication used to treat a number of types of cancer. This includes melanoma, lung cancer, malignant
Lintuzumab (505 words) [view diff] exact match in snippet view article find links to article
Administration and the European Medicines Agency had granted lintuzumab orphan drug status for treatment of AML and myelodysplastic syndromes. Seattle
Worf (7,473 words) [view diff] exact match in snippet view article find links to article
1989), Worf adopts an orphan boy into the House of Mogh. In the first Star Trek episode written by screenwriter Ron Moore, the orphan Jeremy (played by Gabriel
Tislelizumab (446 words) [view diff] no match in snippet view article find links to article
Tislelizumab (BGB-A317) is a humanized monoclonal antibody directed against PD-1. It prevents PD-1 from binding to the ligands PD-L1 and PD-L2 (hence it
Germ cell nuclear factor (917 words) [view diff] exact match in snippet view article find links to article
Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated
Itolizumab (277 words) [view diff] no match in snippet view article find links to article
Itolizumab (INN, trade name Alzumab) is a ‘first in class’ humanized IgG1 monoclonal antibody developed by Biocon and the Center of Molecular Immunology
Nilotinib (1,676 words) [view diff] no match in snippet view article find links to article
Nilotinib, sold under the brand name Tasigna marketed worldwide by Novartis, is a medication used to treat chronic myelogenous leukemia (CML) which has
Ranirestat (298 words) [view diff] exact match in snippet view article find links to article
neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin. It has been granted orphan drug status. The drug is to be used orally. A Canadian Phase III clinical
The Shakespeare Stealer (616 words) [view diff] exact match in snippet view article find links to article
place in the Elizabethan-era England, it recounts the story of Widge, an orphan whose master sends him to steal Hamlet from The Lord Chamberlain's Men.
GPR3 (1,932 words) [view diff] exact match in snippet view article find links to article
neurons, helping symptoms of Alzheimer’s disease. GPR3 is largely known as an orphan G protein-coupled receptor. Even though it does not have any endogenous
Azacitidine (1,760 words) [view diff] no match in snippet view article find links to article
Azacitidine, sold under the brand name Vidaza among others, is used for the treatment of myelodysplastic syndrome, myeloid leukemia, and juvenile myelomonocytic
Eribulin (1,999 words) [view diff] exact match in snippet view article find links to article
population, Eisai was able to file a New Drug Application (NDA) under the orphan and rare disease designation. On January 28, 2016, the U.S. Food and Drug
Clear Paddock Creek (161 words) [view diff] exact match in snippet view article find links to article
Clear Paddock Creek is a tributary of Orphan School Creek, which in turn, is a tributary of Prospect Creek, located in the City of Fairfield, NSW. It flows
Benjamin Sisko (3,164 words) [view diff] no match in snippet view article find links to article
Benjamin Lafayette Sisko is a fictional character in the Star Trek franchise portrayed by Avery Brooks. He first appears in the television series Star
Rifampicin (4,829 words) [view diff] no match in snippet view article find links to article
Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium
Ranibizumab (2,315 words) [view diff] no match in snippet view article find links to article
Ranibizumab, sold under the brand name Lucentis among others, is a monoclonal antibody fragment (Fab) created from the same parent mouse antibody as bevacizumab
Tisagenlecleucel (1,346 words) [view diff] no match in snippet view article find links to article
Tisagenlecleucel, sold under the brand name Kymriah, is a CAR T cells medication for the treatment of B-cell acute lymphoblastic leukemia (ALL) which uses
Sutimlimab (790 words) [view diff] exact match in snippet view article find links to article
disease as defined in the study. The application for sutimlimab received orphan drug, breakthrough therapy, and priority review designations. On 15 September
Rhoticity in English (9,301 words) [view diff] exact match in snippet view article find links to article
as boss–bourse. Specifically, the phonemic merger of the words often and orphan was a running gag in the Gilbert and Sullivan musical, The Pirates of Penzance
Panobinostat (1,177 words) [view diff] no match in snippet view article find links to article
Panobinostat, sold under the brand name Farydak, is a medication used for the treatment of various cancers. It is a hydroxamic acid and acts as a non-selective
Winston Smith (Nineteen Eighty-Four) (852 words) [view diff] no match in snippet view article
Winston Smith is a fictional character and the main protagonist of George Orwell's dystopian 1949 novel Nineteen Eighty-Four. The character was employed
Amatuximab (955 words) [view diff] exact match in snippet view article find links to article
amatuximab orphan drug status for use in malignant pleural mesothelioma in November 2012, and the European Commission soon followed granting orphan drug status
GPCR neuropeptide receptor (261 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Pyroglutamylated RFamide peptide receptor (610 words) [view diff] exact match in snippet view article find links to article
"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10
Renly Baratheon (1,099 words) [view diff] no match in snippet view article find links to article
Renly Baratheon is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Spectrum Pharmaceuticals (520 words) [view diff] no match in snippet view article find links to article
Spectrum Pharmaceuticals is an American biopharmaceutical company. The company is located in Irvine, California. Spectrum develops and markets drugs for
Silly Symphony (2,225 words) [view diff] exact match in snippet view article find links to article
to this include Three Little Pigs, The Tortoise and the Hare, and Three Orphan Kittens, which all had sequels). The series is notable for its innovation
Neuropeptides B/W receptor 2 (461 words) [view diff] exact match in snippet view article find links to article
(2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32
Small nucleolar RNA (3,580 words) [view diff] exact match in snippet view article find links to article
loops in the snoRNA sequence. However, there are increasing numbers of 'orphan' guides without any known RNA targets, which suggests that there might be
Claude Frollo (1,754 words) [view diff] exact match in snippet view article find links to article
Dame. Dom Claude Frollo is a pious and highly knowledgeable man who was orphaned along with his younger brother Jehan when their parents died of the plague
Remdesivir (9,808 words) [view diff] exact match in snippet view article find links to article
condition as a result of the outbreak in the Czech Republic. In February 2016, orphan designation (EU/3/16/1615) was granted by the European Commission to Gilead
Everolimus (2,448 words) [view diff] no match in snippet view article find links to article
Everolimus, sold under the brand name Afinitor among others, is a medication used as an immunosuppressant to prevent rejection of organ transplants and
Inebilizumab (989 words) [view diff] exact match in snippet view article find links to article
and Drug Administration (FDA) granted the application for inebilizumab orphan drug designation and granted approval of Uplizna to Viela Bio. In November
Claude Frollo (1,754 words) [view diff] exact match in snippet view article find links to article
Dame. Dom Claude Frollo is a pious and highly knowledgeable man who was orphaned along with his younger brother Jehan when their parents died of the plague
Everolimus (2,448 words) [view diff] no match in snippet view article find links to article
Everolimus, sold under the brand name Afinitor among others, is a medication used as an immunosuppressant to prevent rejection of organ transplants and
Street children (6,475 words) [view diff] exact match in snippet view article find links to article
state-run Korean Central News Agency reported that hundreds of homeless orphans "volunteered" to work in manual labor projects, raising concerns over the
Estetrol (2,366 words) [view diff] no match in snippet view article find links to article
Estetrol (E4), or oestetrol, is one of the four natural estrogenic steroid hormones found in humans, along with estrone (E1), estradiol (E2), and estriol
Time Squad (2,369 words) [view diff] exact match in snippet view article find links to article
encounter Otto Osworth (Pamela Adlon), an 8-year-old boy who happens to be an orphan from the 21st century, he is quickly recruited and added to the team. Otto
Cladribine (3,956 words) [view diff] exact match in snippet view article find links to article
were interested in selling the drug because hairy cell leukemia was an orphan disease, so Beutler's lab synthesised and packaged it and supplied it to
Fidaxomicin (1,219 words) [view diff] no match in snippet view article find links to article
Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins
Iva Toguri D'Aquino (2,943 words) [view diff] exact match in snippet view article find links to article
during World War II on The Zero Hour radio show. Toguri called herself "Orphan Ann", but she quickly became inaccurately identified with the name "Tokyo
Qi'ra (2,585 words) [view diff] exact match in snippet view article find links to article
Wars Anthology film Solo: A Star Wars Story, Qi'ra is introduced as an orphaned street thief living on the shipbuilding world of Corellia. She and her
Tezepelumab (719 words) [view diff] no match in snippet view article find links to article
Tezepelumab, sold under the brand name Tezspire, is a human monoclonal antibody used for the treatment of asthma. Tezepelumab blocks thymic stromal lymphopoietin
Leatherface (4,811 words) [view diff] no match in snippet view article find links to article
Leatherface is a fictional character in The Texas Chainsaw Massacre film series created by Kim Henkel and Tobe Hooper. He first appears in The Texas Chain
Huerfano County, Colorado (1,228 words) [view diff] exact match in snippet view article find links to article
Walsenburg. The county, whose name comes from the Spanish huérfano meaning "orphan", was named for the Huerfano Butte, a local landmark. The area of Huerfano
Pembrolizumab (6,265 words) [view diff] exact match in snippet view article find links to article
studies to ensure that the results are valid. Pembrolizumab was granted orphan drug designation for SCLC in October 2017. In June 2018, the US FDA approved
GPR42 (227 words) [view diff] exact match in snippet view article find links to article
PMID 15684720. Brown AJ, Goldsworthy SM, Barnes AA, et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate
Comic Strip Classics (168 words) [view diff] exact match in snippet view article find links to article
Goldberg’s Inventions Toonerville Folks Gasoline Alley Barney Google Little Orphan Annie Popeye Blondie Dick Tracy Alley Oop Nancy Flash Gordon Li'l Abner
Goku (10,530 words) [view diff] no match in snippet view article find links to article
Son Goku is a fictional character and the main protagonist of the Dragon Ball manga series created by Akira Toriyama. He is based on Sun Wukong (known
Pyroglutamylated RFamide peptide receptor (610 words) [view diff] exact match in snippet view article find links to article
"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10
Vancouver Orphan Kitten Rescue Association (2,704 words) [view diff] exact match in snippet view article find links to article
The Vancouver Orphan Kitten Rescue Association (VOKRA) is a no kill, non-profit cat rescue organization in Vancouver, British Columbia, Canada, providing
James Frain (694 words) [view diff] exact match in snippet view article find links to article
The Tunnel (2013), Ferdinand Chevalier in the BBC/Space sci-fi thriller Orphan Black (2015–2017), Theo Galavan/Azrael in Fox's Gotham (2015–2016), and
Peter Brown (Oz) (492 words) [view diff] exact match in snippet view article
being raised by his grandfather; he is one of the long list of orphans or apparent orphans in children's literature (they are notably frequent in the Oz
Tacrolimus (4,040 words) [view diff] no match in snippet view article find links to article
Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection
Heidi (1937 film) (1,299 words) [view diff] exact match in snippet view article
children's book of the same name. The film stars Shirley Temple as the titular orphan, who is taken from her grandfather to live as a companion to Klara, a spoiled
Scenic World (999 words) [view diff] exact match in snippet view article find links to article
Scenic World began building a roller coaster known as the Orphan Rocker, named after the nearby Orphan Rock. This is the first roller coaster to be completely
Lanadelumab (1,247 words) [view diff] exact match in snippet view article find links to article
this trial, Lanadelumab was given Priority Review, Breakthrough Therapy, Orphan Drug designation by the FDA. The phase 3 HELP study evaluated efficacy and
Shadow and Bone (TV series) (3,492 words) [view diff] exact match in snippet view article
eight episodes. The series adapts the story of young Alina Starkov, an orphan and cartographer of the Ravka nation's First Army, as she discovers she
GPR20 (195 words) [view diff] exact match in snippet view article find links to article
Yokomizo T, Shimizu T, Nakamura M (May 2008). "Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins"
Liver X receptor (3,037 words) [view diff] exact match in snippet view article find links to article
cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands
Inigo Montoya (998 words) [view diff] no match in snippet view article find links to article
Inigo Montoya is a fictional character in William Goldman's 1973 novel The Princess Bride. In Rob Reiner's 1987 film adaptation, he was portrayed by Mandy
Children's Aid Society (1,543 words) [view diff] exact match in snippet view article find links to article
adults. Brace was appalled by the thousands of abandoned, abused, and orphaned children living in the slums and on the streets of New York at the time
Melphalan flufenamide (2,161 words) [view diff] exact match in snippet view article find links to article
The application for melphalan flufenamide was granted priority review and orphan drug designations. On 23 June 2022, the Committee for Medicinal Products
Isatuximab (3,197 words) [view diff] exact match in snippet view article find links to article
have demonstrated disease progression on the last therapy. It was granted orphan drug designation for multiple myeloma by the European Medicines Agency (EMA)
C5AR2 (701 words) [view diff] exact match in snippet view article find links to article
1016/S0161-5890(00)00067-5. PMID 11090875. Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a
Binandere language (271 words) [view diff] exact match in snippet view article find links to article
(Guhu-Samane burisi eetaqu ‘turn over, turn s.th. around’) *mbeŋga-masi ‘orphan’, ‘widow and child’ (Suena boga masa ‘destitute widow and child’) *pu +
Maniac Magee (1,681 words) [view diff] exact match in snippet view article find links to article
Exploring themes of racism and inequality, it follows the story of an orphan boy looking for a home in the fictional town of Two Mills. Two Mills is
Hefner (band) (1,098 words) [view diff] exact match in snippet view article
Hefner Soul - Too Pure - 1998 The Hefner Heart - Acuarela Discos - 1999 Orphan Songs - Everlasting Records - 1999 Revelations - Too Pure - 1999 The Hefner
Ivacaftor (3,079 words) [view diff] exact match in snippet view article find links to article
M. Orenstein; Carlos E. Milla (2 October 2013). "Viewpoint: Pricing for Orphan Drugs: Will the Market Bear What Society Cannot?". JAMA. 310 (13): 1343–1344
Jimmy Bennett (779 words) [view diff] exact match in snippet view article find links to article
Daddy Day Care, Hostage, The Amityville Horror, Poseidon, Evan Almighty, Orphan, Shorts, and as young James T. Kirk in the 2009 film Star Trek. He also
Naruto Uzumaki (12,946 words) [view diff] exact match in snippet view article find links to article
felt it was something common in Japanese series. Introduced as a young orphan boy of 12 years with blond, spiky hair and blue eyes, Naruto Uzumaki graduates
Esmeralda (The Hunchback of Notre-Dame) (1,954 words) [view diff] exact match in snippet view article
the love child of Paquette Guybertaut, nicknamed 'la Chantefleurie', an orphaned minstrel's daughter who lives in Rheims. Paquette has become a prostitute
Amitriptyline (8,087 words) [view diff] no match in snippet view article find links to article
Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat cyclic vomiting syndrome (CVS), major
Yun and Yang (1,474 words) [view diff] no match in snippet view article find links to article
Yun (ユン) and Yang (ヤン, Yan) are a pair of fictional characters appearing in the Street Fighter fighting game series. The characters are twin brothers known
Urotensin-II receptor (2,085 words) [view diff] exact match in snippet view article find links to article
(1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14". Nature. 401 (6750): 282–6. Bibcode:1999Natur.401..282A
Alsatian Orphan (229 words) [view diff] exact match in snippet view article find links to article
The Alsatian Orphan / L'Orpheline Alsacienne is a sculpture made by the French artist Auguste Rodin (1840-1917). In the beginning of his career, Rodin
Comic strip (6,471 words) [view diff] exact match in snippet view article find links to article
Alley Oop (1932–present) Bringing Up Father (1913–2000; 87 years) Little Orphan Annie (1924–2010; 86 years) Most newspaper comic strips are syndicated;
Nimotuzumab (803 words) [view diff] exact match in snippet view article find links to article
Immunology, Havana, Cuba) is a humanized monoclonal antibody that as of 2014 had orphan status in the US and EU for glioma, and marketing approval in India, China
Hepatocyte nuclear factor 4 alpha (2,171 words) [view diff] exact match in snippet view article find links to article
F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (Feb 2003). "The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction
Ciclosporin (4,800 words) [view diff] no match in snippet view article find links to article
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It
Vegeta (6,684 words) [view diff] no match in snippet view article find links to article
Vegeta (Japanese: ベジータ, Hepburn: Bejīta) (/vəˈdʒiːtə/ və-JEE-tə), also referred as Prince Vegeta (ベジータ王子, Bejīta-ōji) or more especifically Vegeta IV (ベジータ四世
SUCNR1 (303 words) [view diff] exact match in snippet view article find links to article
Tian H, Ling L (May 2004). "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors". Nature. 429 (6988): 188–93. doi:10.1038/nature02488
Captain Phasma (3,320 words) [view diff] no match in snippet view article find links to article
Captain Phasma is a fictional character in the Star Wars franchise, portrayed by English actress Gwendoline Christie. Introduced in Star Wars: The Force
COUP-TFI (1,476 words) [view diff] exact match in snippet view article find links to article
mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22
Dark Castle Entertainment (482 words) [view diff] exact match in snippet view article find links to article
Reaping (2007) The Reaping DVD (2007) RocknRolla (2008) RocknRolla DVD (2008) Orphan (2009) Whiteout (2009) Whiteout DVD (2009) Ninja Assassin(2009) Ninja Assassin
Nimotuzumab (803 words) [view diff] exact match in snippet view article find links to article
Immunology, Havana, Cuba) is a humanized monoclonal antibody that as of 2014 had orphan status in the US and EU for glioma, and marketing approval in India, China
Little Orphan Annie (1932 film) (221 words) [view diff] exact match in snippet view article
Little Orphan Annie is a 1932 American pre-Code comedy film directed by John S. Robertson, and written by Wanda Tuchock and Tom McNamara. It is based on
David Copperfield (character) (1,072 words) [view diff] exact match in snippet view article
for the funeral. Mr Murdstone and Jane, unwilling to care for the hated orphan, decide to send David to work in the family bottling factory. Life at the
GPR32 (930 words) [view diff] exact match in snippet view article find links to article
initially identified and defined by molecular cloning in 1998 as coding for an orphan receptor, i.e. a protein with an amino acid sequence similar to known receptors
Caffeine citrate (731 words) [view diff] no match in snippet view article find links to article
Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it
Tiratricol (388 words) [view diff] exact match in snippet view article find links to article
resistance and adjuvant therapy of thyroid cancer. It is available as an orphan drug to be prescribed by registered specialists in Europe. Carvalho GA,
Pomalidomide (976 words) [view diff] no match in snippet view article find links to article
Pomalidomide (INN; marketed as Pomalyst in the US and Imnovid in the European Union and Russia) is a derivative of thalidomide marketed by Celgene. It
Ciclosporin (4,800 words) [view diff] no match in snippet view article find links to article
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It
GPR142 (225 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Zenarestat (96 words) [view diff] no match in snippet view article find links to article
Zenarestat (FK-366; FR-74366) is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract, but its development
TLX3 (824 words) [view diff] exact match in snippet view article find links to article
is encoded by the TLX3 gene. RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members
Gusperimus (757 words) [view diff] exact match in snippet view article find links to article
Bristol-Myers Squibb. Currently, it is manufactured and sponsored for use as an orphan drug and for clinical studies by the Japanese company Euro Nippon Kayaku
Sirolimus (6,239 words) [view diff] exact match in snippet view article find links to article
patients. While sirolimus was considered for treatment of LAM, it received orphan drug designation status because LAM is a rare condition. The safety of LAM
Orphan Black (comic book) (593 words) [view diff] exact match in snippet view article
Orphan Black is a limited series of comic books based on the television series Orphan Black, which airs on BBC America in the United States and Space
Comic strip (6,471 words) [view diff] exact match in snippet view article find links to article
Alley Oop (1932–present) Bringing Up Father (1913–2000; 87 years) Little Orphan Annie (1924–2010; 86 years) Most newspaper comic strips are syndicated;
Squall Leonhart (4,676 words) [view diff] exact match in snippet view article find links to article
in an orphanage with the other playable characters, except Rinoa. The orphans were cared for by Edea; although Squall remembers little about his past
Karlani (244 words) [view diff] exact match in snippet view article find links to article
The legend of Karlani in the folklore says: "In his infancy he became an orphan and after losing his family he alone survived and was adopted by the Ormur
Cascadia subduction zone (3,969 words) [view diff] exact match in snippet view article find links to article
Since no earthquake had been observed to produce it, scholars dubbed it an "orphan tsunami." Translating the Japanese calendar, Satake found the incident had
GPR19 (273 words) [view diff] exact match in snippet view article find links to article
acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19". American Journal of Physiology. Regulatory
Sacituzumab govitecan (2,238 words) [view diff] exact match in snippet view article find links to article
small cell lung cancer, and metastatic triple-negative breast cancer. Orphan drug status was granted for small cell lung cancer and pancreatic cancer
Tarextumab (79 words) [view diff] exact match in snippet view article find links to article
as a possible treatment for cancer. In January 2015, the US FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and
Ibrutinib (2,365 words) [view diff] no match in snippet view article find links to article
Ibrutinib, sold under the brand name Imbruvica among others, is a small molecule drug that inhibits B-cell proliferation and survival by irreversibly binding
Acanthamoeba keratitis (2,775 words) [view diff] exact match in snippet view article find links to article
important to vision. Recently, AK has been recognized as an orphan disease and a funded project, orphan diseases Acanthamoeba keratitis (ODAK), has tested the
Defibrotide (1,256 words) [view diff] exact match in snippet view article find links to article
FDA granted the application for defibrotide priority review status and orphan drug designation. The FDA granted approval of Defitelio to Jazz Pharmaceuticals
TinEye (1,063 words) [view diff] exact match in snippet view article find links to article
looking to make use of imagery under orphan works to find the copyright holders of that imagery. Being that orphan works can be defined as "copyrighted
Babacar (band) (259 words) [view diff] exact match in snippet view article
rock supergroup formed in England, featuring former members of Shelleyan Orphan, The Cure, and Presence. The group released one album in their brief existence
Imatinib (5,955 words) [view diff] no match in snippet view article find links to article
Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral chemotherapy medication used to
Clubber Lang (802 words) [view diff] no match in snippet view article find links to article
James "Clubber" Lang is a fictional character created by Sylvester Stallone for the film Rocky III, which was released in 1982. Lang serves as the main
Orphan of Lowood (268 words) [view diff] exact match in snippet view article find links to article
Orphan of Lowood (German: Die Waise von Lowood) is a 1926 German silent drama film directed by Curtis Bernhardt and starring Evelyn Holt, Olaf Fønss and
Sailor Jupiter (3,462 words) [view diff] no match in snippet view article find links to article
Makoto Kino (木野 まこと, Kino Makoto, renamed "Lita Kino" or "Lita Quino" in some English adaptations), better known as Sailor Jupiter (セーラージュピター, Sērā Jupitā)
Faris Scherwiz (1,488 words) [view diff] no match in snippet view article find links to article
Faris Scherwiz is a fictional character in the Final Fantasy series. She first appears in Final Fantasy V as an early antagonist and later one of its protagonists
Shire (pharmaceutical company) (2,978 words) [view diff] exact match in snippet view article
Retrieved 26 March 2016. "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg.com. Bloomberg. 11 November 2013. Archived from the original
Garnet (Final Fantasy) (2,005 words) [view diff] no match in snippet view article
Garnet Til Alexandros XVII is a fictional character in the Final Fantasy series and one of the protagonists of Final Fantasy IX. She is the princess of
Garden of Eden (cellular automaton) (3,484 words) [view diff] exact match in snippet view article
a Garden of Eden if and only if it contains an orphan. For one-dimensional cellular automata, orphans and Gardens of Eden can be found by an efficient
Spinocerebellar ataxia (2,802 words) [view diff] exact match in snippet view article find links to article
the treatment of SCA3. BioBlast has received FDA Fast Track status and Orphan Drug status for their treatment. The information provided by BioBlast in
CCH Pounder (1,092 words) [view diff] exact match in snippet view article find links to article
Joon (1993), Demon Knight (1995), Face/Off (1997), End of Days (1999), Orphan (2009), Avatar (2009), The Mortal Instruments: City of Bones (2013), and
Methoxsalen (696 words) [view diff] no match in snippet view article find links to article
Methoxsalen, sold under the brand name Oxsoralen among others, is a medication used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas
King (Tekken) (2,874 words) [view diff] exact match in snippet view article
iconic characters. The first King used to be a ruthless street brawling orphan with no care in the world except fighting. In one of his fights, King was
Quad City Rollers (261 words) [view diff] exact match in snippet view article find links to article
All-Stars and the Mississippi Massacre, and a junior roller derby team, the Orphan Brigade. Quad City is a member of the Women's Flat Track Derby Association
Adhesion G protein-coupled receptor (3,399 words) [view diff] exact match in snippet view article find links to article
adhesion GPCRs. A majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors . Adhesion GPCRs get their
Oliver Twist (character) (1,358 words) [view diff] exact match in snippet view article
the first child protagonist in an English novel. Based in the 1820s, the orphan, young Oliver is born in a parish workhouse in an unnamed town. His unmarried
Special-purpose entity (1,336 words) [view diff] exact match in snippet view article find links to article
defeat the point of the securitization. Therefore, many SPEs are set up as 'orphan' companies with their shares settled on charitable trust and with professional
21st Genie Awards (65 words) [view diff] exact match in snippet view article find links to article
Maelström Alain DesRochers, The Bottle (La Bouteille) Robert Favreau, The Orphan Muses (Les Muses orphelines) Robert Lepage, Possible Worlds Gary Burns,
Prokineticin receptor 1 (518 words) [view diff] exact match in snippet view article find links to article
and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402
Selinexor (2,511 words) [view diff] exact match in snippet view article find links to article
combination with dexamethasone was granted accelerated approval and was granted orphan drug designation. The FDA granted the approval of Xpovio to Karyopharm Therapeutics
GPR156 (368 words) [view diff] exact match in snippet view article find links to article
Watkins, Lyndsay R.; Orlandi, Cesare (2021-03-30). "In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity". British Journal
Oliver Twist (character) (1,358 words) [view diff] exact match in snippet view article
the first child protagonist in an English novel. Based in the 1820s, the orphan, young Oliver is born in a parish workhouse in an unnamed town. His unmarried
Sarepta Therapeutics (1,078 words) [view diff] no match in snippet view article find links to article
Sarepta Therapeutics, Inc. (Nasdaq: SRPT) is a medical research and drug development company with corporate offices and research facilities in Cambridge
Baxter International (3,607 words) [view diff] no match in snippet view article find links to article
Baxter International Inc. is an American multinational healthcare company with headquarters in Deerfield, Illinois. The company primarily focuses on products
Sylvie (Marvel Cinematic Universe) (4,206 words) [view diff] no match in snippet view article
Sylvie Laufeydottir (born Loki) is a fictional character portrayed by Sophia Di Martino in the Marvel Cinematic Universe (MCU) media franchise, partially
Fidarestat (154 words) [view diff] no match in snippet view article find links to article
Fidarestat (SNK-860) is an aldose reductase inhibitor under investigation for treatment of diabetic neuropathy. Aldose reductase inhibitor for treatment
Adhesion G protein-coupled receptor (3,399 words) [view diff] exact match in snippet view article find links to article
adhesion GPCRs. A majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors . Adhesion GPCRs get their
Blue Sky Black Death (2,098 words) [view diff] exact match in snippet view article find links to article
started producing exclusively around 2000. Kingston, working under the name Orphan, began his solo producing career collaborating with rapper Noah23 and the
Clofazimine (1,943 words) [view diff] exact match in snippet view article find links to article
clarithromycin. However, in the United States, clofazimine is considered an orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC
Vicki (Doctor Who) (1,036 words) [view diff] exact match in snippet view article
the long-running British science fiction television series Doctor Who. An orphan from the 25th century, she was a companion of the First Doctor and a regular
The Royal Alexandra and Albert School (695 words) [view diff] exact match in snippet view article find links to article
Royal Alexandra School, which was founded in 1758, and The Royal Albert orphan School, which was founded in 1864 as a national memorial to Prince Albert
Laura Dern (5,129 words) [view diff] exact match in snippet view article find links to article
received her first Academy Award nomination for her portrayal of the titular orphan in the drama film Rambling Rose (1991), and achieved international recognition
Samus Aran (6,226 words) [view diff] exact match in snippet view article find links to article
Ridley in an attack that killed her parents and destroyed the colony. The orphaned Samus was then found by a bird-like alien race known as the Chozo, who
Second Doctor (2,617 words) [view diff] exact match in snippet view article find links to article
and Polly's departures, the Doctor and Jamie were joined by the Victorian orphan Victoria Waterfield (Deborah Watling) and 21st century astrophysicist Zoe
Cannabidiol (11,339 words) [view diff] exact match in snippet view article find links to article
Sjögren S, Hjorth S, Hermansson NO, Leonova J, et al. (December 2007). "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology
Like Mike (1,332 words) [view diff] exact match in snippet view article find links to article
Lipnicki, Robert Forster, Crispin Glover and Eugene Levy, the film follows an orphan who gets basketball talents after finding an old pair of sneakers that once
Orihime Inoue (2,593 words) [view diff] no match in snippet view article find links to article
Orihime Inoue is a fictional character and in the Bleach manga series and its anime adaptations created by Tite Kubo. She is one of Ichigo Kurosaki's friends
Atezolizumab (3,851 words) [view diff] no match in snippet view article find links to article
Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC)
Lumiliximab (281 words) [view diff] exact match in snippet view article find links to article
antibody that targets CD23. It acts as an immunomodulator and was awarded orphan drug status and fast track designation by the FDA. It was investigated in
Bagheera (2,222 words) [view diff] no match in snippet view article find links to article
Bagheera (Hindi: बघीरा / Baghīrā) is a fictional character in Rudyard Kipling's Mowgli stories in The Jungle Book (coll. 1894) and The Second Jungle Book
Anne Shirley (7,667 words) [view diff] exact match in snippet view article find links to article
had made as a young girl about two siblings who were mistakenly sent an orphan girl instead of the boy they had requested, yet decided to keep her. She
Jay Brown (4,375 words) [view diff] exact match in snippet view article find links to article
gang, coping with the death of his father Jase Dyer (Stephen Lord), being orphaned by age 14 which results in his going into foster care and then being taken
GPR83 (325 words) [view diff] exact match in snippet view article find links to article
"Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83)". Cytogenet Cell Genet. 90 (1–2):
Selphie Tilmitt (2,359 words) [view diff] no match in snippet view article find links to article
Selphie Tilmitt (セルフィ・ティルミット, Serufi Tirumitto) is a fictional character from the 1999 role-playing video game Final Fantasy VIII. She is introduced as
Ovaltine (1,510 words) [view diff] exact match in snippet view article find links to article
their effectiveness are proven. The U.S. children's radio series Little Orphan Annie (1931–1940) and Captain Midnight (1938–1949), and the subsequent Captain
Natty Bumppo (1,416 words) [view diff] no match in snippet view article find links to article
Nathaniel "Natty" Bumppo is a fictional character and the protagonist of James Fenimore Cooper's pentalogy of novels known as the Leatherstocking Tales
Plerixafor (1,642 words) [view diff] exact match in snippet view article find links to article
Further studies led to the new indication for cancer patients. Plerixafor has orphan drug status in the United States and European Union for the mobilization
Jake the Dog (2,760 words) [view diff] no match in snippet view article find links to article
Jake the Dog is a fictional character and one of the two protagonists in the American animated television series Adventure Time created by Pendleton Ward
GPR45 (372 words) [view diff] exact match in snippet view article find links to article
DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
GPR63 (384 words) [view diff] exact match in snippet view article find links to article
1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056
Hebrew Orphan Asylum (Baltimore, Maryland) (756 words) [view diff] exact match in snippet view article
The Hebrew Orphan Asylum is a historic institutional orphanage and former hospital building located in the Mosher neighborhood of Baltimore, Maryland,
GPR52 (357 words) [view diff] exact match in snippet view article find links to article
MacSweeney, Cliona (2021-06-01). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and
Laawaris (1981 film) (784 words) [view diff] exact match in snippet view article
Laawaris (transl. Orphan or Scoundrel ) is a 1981 Indian masala film directed by Prakash Mehra. The film became known for its song "Mere Angene Mein Tumhara
GSK plc (10,472 words) [view diff] no match in snippet view article find links to article
Coordinates: 51°29′17″N 0°19′01″W / 51.4881°N 0.3169°W / 51.4881; -0.3169 GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical
Anaphylatoxin receptors (74 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Kristoff (Frozen) (1,366 words) [view diff] exact match in snippet view article
in the movie, and is introduced in "Frozen Heart", as an eight-year-old orphan boy with his baby reindeer, Sven, who becomes his best friend. He attempts
GPR17 (1,797 words) [view diff] exact match in snippet view article find links to article
functions of this receptor are disputed. Initially discovered in 1998 as an Orphan receptor, i.e. a receptor whose activating ligand(s) and function were unknown
Jane Eyre (character) (3,223 words) [view diff] exact match in snippet view article
of the same name. The story follows Jane's infancy and childhood as an orphan, her employment first as a teacher and then as a governess, and her romantic
Laurie Strode (3,114 words) [view diff] no match in snippet view article find links to article
Laurie Strode is a fictional character in the Halloween franchise by John Carpenter and Debra Hill. She debuted in the original 1978 film as a high school
Snak (739 words) [view diff] no match in snippet view article find links to article
Snak (Danish for "chat") was a shareware Internet Relay Chat (IRC) client written by Kent Sorensen for the Macintosh platform. Snak was distributed as
Heathcliff (Wuthering Heights) (2,517 words) [view diff] no match in snippet view article
Heathcliff is a fictional character in Emily Brontë's 1847 novel Wuthering Heights. Owing to the novel's enduring fame and popularity, he is often regarded
Christine Daaé (2,162 words) [view diff] no match in snippet view article find links to article
Christine Daaé is a fictional character and the female protagonist of Gaston Leroux's 1910 novel The Phantom of the Opera and of the various adaptations
Tafasitamab (556 words) [view diff] no match in snippet view article find links to article
Tafasitamab, sold under the brand name Monjuvi, is a medication used in combination with lenalidomide for the treatment of adults with relapsed or refractory
Annie Warbucks (833 words) [view diff] exact match in snippet view article find links to article
to the 1977 Tony Award-winning hit Annie, based on Harold Gray's Little Orphan Annie comic strip, it begins immediately after Annie ends. On Christmas
Zanubrutinib (1,314 words) [view diff] exact match in snippet view article find links to article
priority review, accelerated approval, breakthrough therapy designation, and orphan drug designation. The FDA approved zanubrutinib in November 2019, and granted
Genzyme (2,013 words) [view diff] exact match in snippet view article find links to article
world’s population. Drugs used to treat such conditions are considered to be orphan drugs. Ceredase was the first effective treatment for Gaucher's disease
Pharmaceutical industry (12,186 words) [view diff] exact match in snippet view article find links to article
benefit to society. There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases