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searching for Orphan 530 found (102761 total)

alternate case: orphan

Orphan Black (8,065 words) [view diff] exact match in snippet view article find links to article

Orphan Black is a Canadian science fiction thriller television series created by screenwriter Graeme Manson and director John Fawcett, and starring Tatiana
Vesper Lynd (1,910 words) [view diff] exact match in snippet view article find links to article
Vesper and Bond size each other up, and each deduce that the other is an orphan. Vesper is initially skeptical about Bond's ego and at first is unwilling
Tatiana Maslany (3,414 words) [view diff] exact match in snippet view article find links to article
playing multiple characters in the science fiction thriller television series Orphan Black (2013–2017), which won her a Primetime Emmy Award (2016), a TCA Award
Diageo (2,855 words) [view diff] no match in snippet view article find links to article
Diageo plc (/diˈædʒioʊ/) is a multinational beverage alcohol company, with its headquarters in London, England. It operates in more than 180 countries
Rogue planet (2,981 words) [view diff] exact match in snippet view article find links to article
rogue planet (also termed an interstellar, nomad, free-floating, unbound, orphan, wandering, starless, or sunless planet) is an interstellar object of planetary-mass
Orphan drug (4,061 words) [view diff] exact match in snippet view article find links to article
An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without
Rare disease (1,935 words) [view diff] exact match in snippet view article find links to article
affects a small percentage of the population. In some parts of the world, an orphan disease is a rare disease whose rarity means there is a lack of a market
Temple Riders (122 words) [view diff] exact match in snippet view article find links to article
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions
Acronym (13,981 words) [view diff] exact match in snippet view article find links to article
"K9" (kay-nine) for "canine". Pseudo-acronyms also frequently develop as "orphan initialisms"; an existing acronym is redefined as a non-acronymous name
Annie (musical) (7,373 words) [view diff] exact match in snippet view article
Broadway musical based upon the popular Harold Gray comic strip Little Orphan Annie and loosely based on the 1885 poem Little Orphant Annie written by
RAR-related orphan receptor gamma (2,321 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is member of the
European Medicines Agency (2,637 words) [view diff] exact match in snippet view article find links to article
CHMP as described above. The Committee on Orphan Medicinal Products (COMP) administers the granting of orphan drug status since 2000. Companies intending
Little Orphan Annie (7,532 words) [view diff] exact match in snippet view article find links to article
Little Orphan Annie is a daily American comic strip created by Harold Gray and syndicated by the Tribune Media Services. The strip took its name from the
RAR-related orphan receptor (1,110 words) [view diff] exact match in snippet view article find links to article
The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR
Cassandra Cain (6,075 words) [view diff] exact match in snippet view article find links to article
Batgirl. Over the years, she has also assumed the code names of Black Bat, Orphan, and in current stories, shares the Batgirl name with Stephanie Brown. Cassandra's
Orphan (2009 film) (2,210 words) [view diff] exact match in snippet view article
Orphan is a 2009 psychological horror film directed by Jaume Collet-Serra and written by David Leslie Johnson from a story by Alex Mace. The film stars
RAR-related orphan receptor beta (1,030 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans
Orphan receptor (727 words) [view diff] exact match in snippet view article find links to article
a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan". Conversely, the term orphan ligand refers to
RAR-related orphan receptor alpha (2,661 words) [view diff] exact match in snippet view article find links to article
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is
Nuclear receptor 4A3 (1,321 words) [view diff] exact match in snippet view article find links to article
(nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene
Orphanet (1,057 words) [view diff] exact match in snippet view article find links to article
providing information about rare diseases as well as corresponding diagnosis, orphan drugs, clinical trials and expert networks The website is managed by a consortium
Orphan work (1,477 words) [view diff] exact match in snippet view article find links to article
An orphan work is a copyright-protected work for which rightsholders are positively indeterminate or uncontactable. Sometimes the names of the originators
Isabelle Fuhrman (1,260 words) [view diff] exact match in snippet view article find links to article
best known for her roles as Esther in the 2009 psychological horror film Orphan and Clove in the 2012 dystopian adventure film The Hunger Games. She has
Retinoic acid-inducible orphan G protein-coupled receptor (370 words) [view diff] exact match in snippet view article find links to article
The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression
Lord Voldemort (7,910 words) [view diff] no match in snippet view article find links to article
Lord Voldemort (/ˈvoʊldəmɔːr/, /-mɔːrt/ in the films) is a sobriquet for Tom Marvolo Riddle, a fictional character and the main antagonist in J. K. Rowling's
Texas Blind, Deaf, and Orphan School (558 words) [view diff] exact match in snippet view article find links to article
Texas Blind, Deaf, and Orphan School was a school for blind and deaf black people in Austin, Texas. Throughout its history, due to educational segregation
AstraZeneca (6,861 words) [view diff] exact match in snippet view article find links to article
would partner with Orca Pharmaceuticals to develop retinoic acid-related orphan nuclear receptor gamma inhibitors for use in the treatment of a number of
Tom Sawyer (510 words) [view diff] no match in snippet view article find links to article
Thomas Sawyer (/ˈsɔːjər/) is the title character of the Mark Twain novel The Adventures of Tom Sawyer (1876). He appears in three other novels by Twain:
Small heterodimer partner (1,773 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
X-Statix (2,280 words) [view diff] exact match in snippet view article find links to article
Allred. The storyline (which features the returns of the Anarchist, the Orphan, and U-Go Girl) parodies the manner in which creators in the industry handle
Orphan wells (1,769 words) [view diff] exact match in snippet view article find links to article
Orphan, orphaned or abandoned wells are oil or gas wells that have been abandoned by fossil fuel extraction industries. These wells may have been deactivated
Widows and orphans (803 words) [view diff] exact match in snippet view article find links to article
In typesetting, widows and orphans are lines at the beginning or end of a paragraph which are left dangling at the top or bottom of a page or column,
Johns Hopkins (4,307 words) [view diff] exact match in snippet view article find links to article
female orphans principally as domestic workers, and next as an "orthopedic convalescent" home and school for "colored crippled" children and orphans. The
Testicular receptor 2 (925 words) [view diff] exact match in snippet view article find links to article
1016/S0006-291X(89)80028-2. PMID 2597158. Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate
Reed's School (2,129 words) [view diff] exact match in snippet view article find links to article
Kingdom. The foundation was established to provide relief to destitute orphans, including children whose fathers had died and whose mothers were unable
Oliver Twist (5,995 words) [view diff] exact match in snippet view article find links to article
1837 to 1839, and as a three-volume book in 1838. Born in a workhouse, the orphan Oliver Twist is sold into apprenticeship with an undertaker. After escaping
Wanda Maximoff (Marvel Cinematic Universe) (6,856 words) [view diff] no match in snippet view article
Wanda Maximoff is a fictional character portrayed by Elizabeth Olsen in the Marvel Cinematic Universe (MCU) media franchise who is based on the Marvel
Tocilizumab (3,543 words) [view diff] no match in snippet view article find links to article
Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic
Orphan Girl at the Cemetery (331 words) [view diff] exact match in snippet view article find links to article
The Orphan Girl at the cemetery (also known as Young Orphan Girl in the Cemetery; French: Jeune orpheline au cimetière) (c. 1823 or 1824) is a painting
Kato (The Green Hornet) (3,219 words) [view diff] no match in snippet view article
Kato is a fictional character from The Green Hornet series. This character has appeared with the Green Hornet in film, television, book and comic book
Peeta Mellark (2,594 words) [view diff] no match in snippet view article find links to article
Peeta Mellark is a fictional character from The Hunger Games trilogy by Suzanne Collins. He is portrayed by actor Josh Hutcherson in The Hunger Games film
Freddy Krueger (4,873 words) [view diff] no match in snippet view article find links to article
Freddy Krueger (/ˈkruːɡər/) is a fictional character in the A Nightmare on Elm Street film series. He first appeared in Wes Craven's A Nightmare on Elm
Midway University (1,319 words) [view diff] exact match in snippet view article find links to article
undergraduate students. Midway University originally opened as the Kentucky Female Orphan School on October 3, 1849, with one teacher and sixteen female students
Freddy Krueger (4,873 words) [view diff] no match in snippet view article find links to article
Freddy Krueger (/ˈkruːɡər/) is a fictional character in the A Nightmare on Elm Street film series. He first appeared in Wes Craven's A Nightmare on Elm
Midway University (1,319 words) [view diff] exact match in snippet view article find links to article
undergraduate students. Midway University originally opened as the Kentucky Female Orphan School on October 3, 1849, with one teacher and sixteen female students
Amgen (2,470 words) [view diff] exact match in snippet view article find links to article
Swedish Orphan Biovitrum, in December 2008) Kineret (anakinra) for rheumatoid arthritis, exclusively licensed to Biovitrium, now Swedish Orphan Biovitrum
Colchicine (5,003 words) [view diff] exact match in snippet view article find links to article
for Colcrys in the treatment of familial Mediterranean fever, under the Orphan Drug Law. URL Pharma then raised the price per tablet from $0.09 to $4.85
Methotrexate (2,739 words) [view diff] no match in snippet view article find links to article
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases
Class C GPCR (251 words) [view diff] exact match in snippet view article find links to article
(GRM5) mGluR6 (GRM6) mGluR7 (GRM7) mGluR8 (GRM8) Retinoic acid-inducible orphan G protein-coupled receptors (RAIG) RAIG1 (GPRC5A) RAIG2 (GPRC5B) RAIG3 (GPRC5C)
Sodium oxybate (4,098 words) [view diff] exact match in snippet view article find links to article
approved for treating symptoms of narcolepsy in the European Union in 2005. Orphan Medical had developed it and was acquired by Jazz Pharmaceuticals in 2005
Hydrocortisone (1,197 words) [view diff] no match in snippet view article find links to article
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital
Laurie Strode (3,012 words) [view diff] no match in snippet view article find links to article
Laurie Strode is a fictional character in the Halloween franchise by John Carpenter and Debra Hill. She debuted in the original 1978 film as a high school
Ambrisentan (555 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) and the European Medicines Agency (EMA), and designated an orphan drug, for the treatment of pulmonary hypertension. Ambrisentan is indicated
Testicular receptor 4 (1,135 words) [view diff] exact match in snippet view article find links to article
Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings
Gord the Rogue (2,510 words) [view diff] exact match in snippet view article find links to article
novel, Dance of Demons. The series of novels follows the progress of the orphan beggar Gord, from his lowly youth to his ascension as an avatar of Balance
Nuclear receptor 4A1 (2,436 words) [view diff] exact match in snippet view article find links to article
homodimer to NurRE. It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription
Amifampridine (3,100 words) [view diff] exact match in snippet view article find links to article
Amifampridine phosphate has orphan drug status in the EU for Lambert–Eaton myasthenic syndrome and Catalyst holds both an orphan designation and a breakthrough
Solriamfetol (751 words) [view diff] exact match in snippet view article find links to article
adults with narcolepsy or obstructive sleep apnea (OSA). It was granted orphan drug designation. The U.S. Food and Drug Administration (FDA) approved solriamfetol
The Orphan Master's Son (1,050 words) [view diff] exact match in snippet view article find links to article
The Orphan Master's Son is a 2012 novel by American author Adam Johnson. It deals with intertwined themes of propaganda, identity, and state power in North
Vito Corleone (2,102 words) [view diff] exact match in snippet view article find links to article
Robert De Niro as a young man in The Godfather Part II (1974). He is an orphaned Sicilian immigrant who builds a Mafia empire. He and his wife Carmela have
Itachi Uchiha (3,129 words) [view diff] no match in snippet view article find links to article
Itachi Uchiha (Japanese: うちは イタチ, Hepburn: Uchiha Itachi) is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto. Itachi
Huckleberry Finn (1,529 words) [view diff] no match in snippet view article find links to article
Huckleberry "Huck" Finn is a fictional character created by Mark Twain who first appeared in the book The Adventures of Tom Sawyer (1876) and is the protagonist
Sotalol (1,504 words) [view diff] no match in snippet view article find links to article
Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. It is only recommended in those
Infigratinib (243 words) [view diff] exact match in snippet view article find links to article
fibroblast growth factor receptors FGFR1, FGFR2 and FGFR3 It was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2019, and it was
Tetrabenazine (564 words) [view diff] no match in snippet view article find links to article
Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is sold under the brand names Nitoman and Xenazine among others
Itraconazole (2,305 words) [view diff] exact match in snippet view article find links to article
"Itraconazole Orphan Drug Designation". U.S. Food and Drug Administration (FDA). 19 May 2016. Retrieved 15 May 2020. "Itraconazole Orphan Drug Designation"
Stiripentol (1,106 words) [view diff] exact match in snippet view article find links to article
December 2001, the European Medicines Agency (EMA) granted stiripentol orphan drug status (designation number EU/3/01/071) for the treatment of severe
Nuclear receptor (6,515 words) [view diff] exact match in snippet view article find links to article
target nuclear receptors. A number of nuclear receptors, referred to as orphan receptors, have no known (or at least generally agreed upon) endogenous
Orphan of the Pecos (697 words) [view diff] exact match in snippet view article find links to article
Orphan of the Pecos is a 1937 American Western film produced and directed by Sam Katzman and starring Tom Tyler, Jeanne Martel, Howard Bryant, and Forrest
Burosumab (789 words) [view diff] exact match in snippet view article find links to article
April 2018. The FDA approval fell under both the breakthrough therapy and orphan drug designations. It was approved for use in the European Union in February
Emapalumab (665 words) [view diff] exact match in snippet view article find links to article
normal catabolism. The U.S. Food and Drug Administration (FDA) granted orphan drug designations in 2010 and 2020, and breakthrough therapy designation
Liver receptor homolog-1 (1,327 words) [view diff] exact match in snippet view article find links to article
mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of
NAGly receptor (1,143 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous
COUP-TFII (1,548 words) [view diff] exact match in snippet view article find links to article
PMID 8530078. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development"
Estrogen-related receptor (1,169 words) [view diff] exact match in snippet view article find links to article
The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of
Anagrelide (875 words) [view diff] exact match in snippet view article find links to article
Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (also
Islamic adoptional jurisprudence (1,103 words) [view diff] exact match in snippet view article find links to article
child who is not one's genetic child is allowed and, in the case of an orphan, even encouraged. But, according to the Islamic view, the child does not
Benralizumab (232 words) [view diff] exact match in snippet view article find links to article
treatment of severe eosinophilic asthma. It was granted designation as an orphan drug by the Food and Drug Administration for treatment of eosinophilic oesophagitis
Rifaximin (1,845 words) [view diff] exact match in snippet view article find links to article
avoided in such cases.[citation needed] In the United States, rifaximin has orphan drug status for the treatment of hepatic encephalopathy. Although high-quality
Pramiracetam (398 words) [view diff] exact match in snippet view article find links to article
Phase II trials showed mixed results; it then began to develop it as an orphan drug as an adjunct to electroconvulsive therapy for major depressive disorder
Orphan Train (5,245 words) [view diff] exact match in snippet view article find links to article
The Orphan Train Movement was a supervised welfare program that transported children from crowded Eastern cities of the United States to foster homes located
Teduglutide (297 words) [view diff] exact match in snippet view article find links to article
restoring gastric emptying and secretion. In Europe it has been granted orphan drug status and is marketed under the brand Revestive by Nycomed. It was
Estrogen-related receptor alpha (2,006 words) [view diff] exact match in snippet view article find links to article
that estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor. ERRα has wide tissue distribution but it is most highly
Glutamine (1,970 words) [view diff] exact match in snippet view article find links to article
extremities, back pain and chest pain. L-glutamine oral powder received orphan drug designation. The FDA granted the approval of Endari to Emmaus Medical
Eculizumab (2,891 words) [view diff] exact match in snippet view article find links to article
tax incentives in the Orphan Drug Act of 1983. On average the cost per person for orphan drugs is "six times that of non-orphan drugs, a clear indication
Elizabeth Schuyler Hamilton (4,529 words) [view diff] exact match in snippet view article find links to article
is recognized as an early American philanthropist for her work with the Orphan Asylum Society. Elizabeth was born in Albany, New York, the second daughter
Merck & Co. (8,001 words) [view diff] exact match in snippet view article find links to article
VLS-101, an antibody-drug conjugate designed to target Tyrosine kinase-like orphan receptor 1 (ROR1) in both hematological and solid tumors. VLS-101 is currently
ELTD1 (446 words) [view diff] exact match in snippet view article find links to article
and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this
Remdesivir (9,612 words) [view diff] exact match in snippet view article find links to article
as a result of the outbreak in the Czech Republic. On 17 February 2016, orphan designation (EU/3/16/1615) was granted by the European Commission to Gilead
Remdesivir (9,612 words) [view diff] exact match in snippet view article find links to article
as a result of the outbreak in the Czech Republic. On 17 February 2016, orphan designation (EU/3/16/1615) was granted by the European Commission to Gilead
Superfund (5,064 words) [view diff] exact match in snippet view article find links to article
is allocable among PRPs in contribution based on comparative fault. An "orphan share" is the share of costs at a Superfund site that is attributable to
Vera Farmiga (7,383 words) [view diff] exact match in snippet view article find links to article
Primetime Emmy Award nomination. These roles, along with Joshua (2007) and Orphan (2009), established her as a scream queen. For her portrayal of a lawyer
SREB (133 words) [view diff] exact match in snippet view article find links to article
ligands have yet been identified for these receptors, they are classified as orphan receptors. Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi
Three Orphan Kittens (1,196 words) [view diff] exact match in snippet view article find links to article
Three Orphan Kittens is a 1935 animated short film in the Silly Symphonies series produced by Walt Disney Productions. It was the winner of the 1935 Oscar
Awful Orphan (634 words) [view diff] exact match in snippet view article find links to article
Awful Orphan is a 1949 Warner Bros. Merrie Melodies cartoon, directed by Chuck Jones and written by Michael Maltese. It is a sequel to the 1947 Looney
Track gauge conversion (802 words) [view diff] exact match in snippet view article find links to article
gauge conversion work, some stations and branch lines may become "gauge orphans". Trains can't operate to them until costly gauge conversion work is completed
Olaratumab (896 words) [view diff] exact match in snippet view article find links to article
2010. In February 2015, the European Medicines Agency assigned olaratumab orphan drug status for the treatment of soft-tissue sarcoma. The European Commission
ELTD1 (446 words) [view diff] exact match in snippet view article find links to article
and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this
Orphan Train (5,245 words) [view diff] exact match in snippet view article find links to article
The Orphan Train Movement was a supervised welfare program that transported children from crowded Eastern cities of the United States to foster homes located
Daratumumab (1,531 words) [view diff] exact match in snippet view article find links to article
breakthrough therapy drug status in 2013, for multiple myeloma. It was awarded orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular
GPR148 (304 words) [view diff] exact match in snippet view article find links to article
G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and
Jon Snow (character) (8,466 words) [view diff] exact match in snippet view article
introduced in A Game of Thrones (1996), as he and his five siblings adopt six orphaned direwolf cubs. Jon takes the runt of the litter, a white cub that he names
Loki (Marvel Cinematic Universe) (6,974 words) [view diff] no match in snippet view article
Loki Laufeyson, known by adoption as Loki Odinson and by his title as the God of Mischief, is a fictional character portrayed by Tom Hiddleston in the
Bosentan (1,060 words) [view diff] no match in snippet view article find links to article
Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery
Mitotane (743 words) [view diff] exact match in snippet view article find links to article
Mitotane has been produced by Bristol Myers Squibb but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in
Nitric oxide (2,151 words) [view diff] no match in snippet view article find links to article
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO. It is one of the principal oxides of nitrogen. Nitric oxide
Reoviridae (1,841 words) [view diff] exact match in snippet view article find links to article
tract. The name "reo-" is an acronym for "respiratory enteric orphan" viruses. The term "orphan virus" refers to the fact that some of these viruses have
Little Orphan Airedale (228 words) [view diff] exact match in snippet view article find links to article
Little Orphan Airedale is a Warner Bros. Looney Tunes cartoon directed by Charles M. Jones and released on October 4, 1947. Its major significance is its
AbbVie (2,142 words) [view diff] no match in snippet view article find links to article
AbbVie is an American publicly traded biopharmaceutical company founded in 2013. It originated as a spin-off of Abbott Laboratories. On October 19, 2011
Alvocidib (457 words) [view diff] exact match in snippet view article find links to article
the name) and later from Dysoxylum binectariferum. The FDA has granted orphan drug designation to alvocidib for the treatment of patients with acute myeloid
Nami (One Piece) (2,096 words) [view diff] no match in snippet view article
Nami (Japanese: ナミ, Japanese: [na̠mʲi]) is a fictional character in the One Piece franchise created by Eiichiro Oda. She is based on Ann and Silk, two
GPR158 (398 words) [view diff] exact match in snippet view article find links to article
protein that in humans is encoded by the GPR158 gene. This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7
Boba Fett (9,613 words) [view diff] no match in snippet view article find links to article
Boba Fett (/ˌboʊbə ˈfɛt, ˌbɒ-/) is a fictional character in the Star Wars franchise. He is an armored bounty hunter featured in both the original and prequel
Rev-ErbA alpha (4,261 words) [view diff] exact match in snippet view article find links to article
through autoregulation and regulation by retinoic acid receptor-related orphan receptor alpha (RORɑ), another nuclear receptor transcription factor. NR1D1
GPR12 (322 words) [view diff] exact match in snippet view article find links to article
in humans is encoded by the GPR12 gene. The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene
Estrogen-related receptor gamma (1,268 words) [view diff] exact match in snippet view article find links to article
hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists
Rilonacept (409 words) [view diff] exact match in snippet view article find links to article
of human IgG1 that binds and neutralizes IL-1. Rilonacept was given an orphan drug designation by the U.S. Food and Drug Administration (FDA) and is used
Peter Sarsgaard (4,771 words) [view diff] exact match in snippet view article find links to article
films such as Flightplan (2005), Jarhead (2005), The Skeleton Key (2005), Orphan (2009), An Education (2009), Knight and Day (2010), Green Lantern (2011)
Honey Ryder (1,195 words) [view diff] exact match in snippet view article find links to article
shell diver, descended from an old-established colonial family. She was orphaned at the age of five when her parents' house was burnt down. She then lived
Sodium thiosulfate (1,454 words) [view diff] no match in snippet view article find links to article
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na2S2O3.xH2O. Typically it is available as the white or colorless pentahydrate
Institut Catholique de Paris (1,287 words) [view diff] no match in snippet view article find links to article
The Institut Catholique de Paris (ICP), known in English as the Catholic University of Paris (and in Latin as Universitas catholica Parisiensis), is a
Larotrectinib (528 words) [view diff] exact match in snippet view article find links to article
licensed to Loxo Oncology in 2013. Larotrectinib was initially awarded orphan drug status in 2015, for soft tissue sarcoma, and breakthrough therapy designation
Samus Aran (6,093 words) [view diff] exact match in snippet view article find links to article
Ridley in an attack that killed her parents and destroyed the colony. The orphaned Samus was then found by a bird-like alien race known as the Chozo, who
Iduronidase (2,088 words) [view diff] exact match in snippet view article find links to article
enjoys orphan drug status in both the United States and the European Union, though in both its orphan drug exclusivity period has expired. (Orphan drug
Ibalizumab (652 words) [view diff] exact match in snippet view article find links to article
trial for s.c. and i.m. injection dosage forms (on-going). 2014: granted orphan drug designation for HIV MDR patients by U.S. FDA. 2015: granted breakthrough
Mowgli (2,008 words) [view diff] no match in snippet view article find links to article
Mowgli /ˈmaʊɡli/ is a fictional character and the protagonist of Rudyard Kipling's The Jungle Book stories. He is a feral boy from the Pench area in Seoni
Often an Orphan (611 words) [view diff] exact match in snippet view article find links to article
Often an Orphan is a 1949 cartoon in the Merrie Melodies series. The cartoon was released on August 13, 1949 and stars Charlie Dog and Porky Pig. The cartoon
List of Dove Medical Press academic journals (679 words) [view diff] exact match in snippet view article find links to article
Statistics† Open Access Rheumatology: Research and Reviews Open Access Surgery Orphan Drugs: Research and Reviews† Orthopedic Research and Reviews Pathology and
Abandonware (8,685 words) [view diff] exact match in snippet view article find links to article
abandonware is a software (or hardware) sub-case of the general concept of orphan works. Museums and various organizations dedicated to preserving this software
2nd Canadian Screen Awards (246 words) [view diff] exact match in snippet view article find links to article
nominations, while in the television categories, the science fiction series Orphan Black received 14 nominations. The awards ceremony were hosted by Martin
General German Protestant Orphans Home (149 words) [view diff] exact match in snippet view article find links to article
General German Protestant Orphans Home, also known as the Pleasant Run Children's Home , is a historic orphanage located in Indianapolis, Indiana. It
Teprotumumab (910 words) [view diff] exact match in snippet view article find links to article
Phase I for diabetic macular edema. It was granted Breakthrough Therapy, Orphan Drug Status and Fast Track designations by the FDA for Graves' ophthalmopathy
GPRC5A (696 words) [view diff] exact match in snippet view article find links to article
dysregulated in many human cancers and in other diseases. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000013588 -
Cubone (1,390 words) [view diff] no match in snippet view article find links to article
Cubone, known in Japan as Karakara (カラカラ), is a Pokémon species in Nintendo and Game Freak's Pokémon franchise. Designed by Ken Sugimori and first introduced
Lombard, Illinois (2,057 words) [view diff] exact match in snippet view article find links to article
Gray's parents and the studio of Harold Gray, the originator of Little Orphan Annie cartoon strip. Harold Gray used the home's study to work on the Annie
Gamora (Marvel Cinematic Universe) (2,754 words) [view diff] exact match in snippet view article
and her uncertainty over the film's commercial viability. Gamora is an orphan from an alien world who seeks redemption for her past crimes. She was trained
Rasagiline (1,895 words) [view diff] no match in snippet view article find links to article
Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease
The Orphan of Zhao (2,659 words) [view diff] exact match in snippet view article find links to article
The Orphan of Zhao is a Chinese play from the Yuan era, attributed to the 13th-century dramatist Ji Junxiang (紀君祥). The play has as its full name The Great
Teprotumumab (910 words) [view diff] exact match in snippet view article find links to article
Phase I for diabetic macular edema. It was granted Breakthrough Therapy, Orphan Drug Status and Fast Track designations by the FDA for Graves' ophthalmopathy
Durvalumab (1,182 words) [view diff] no match in snippet view article find links to article
Durvalumab (trade name Imfinzi) is an FDA-approved immunotherapy for cancer, developed by Medimmune/AstraZeneca. It is a human immunoglobulin G1 kappa
Budesonide (2,224 words) [view diff] no match in snippet view article find links to article
Budesonide (BUD), sold under the brand name Pulmicort among others, is a medication of the corticosteroid type. It is available as an inhaler, nebulization
Han Solo (5,023 words) [view diff] exact match in snippet view article find links to article
Alden Ehrenreich. In the film, 19-year old Han is characterized to be an orphan on the planet Corellia. He and his lover, Qi'ra (Emilia Clarke), attempt
Rasagiline (1,895 words) [view diff] no match in snippet view article find links to article
Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease
Annie (2014 film) (3,821 words) [view diff] exact match in snippet view article
musical of the same name (which in turn is based on the comic strip Little Orphan Annie by Harold Gray), the film stars Quvenzhané Wallis in the title role
Rickon Stark (1,758 words) [view diff] no match in snippet view article find links to article
Rickon Stark is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Break of gauge (5,459 words) [view diff] exact match in snippet view article find links to article
new gauge. These severed branches can be called gauge orphans. The opposite of a gauge orphan is a line of one gauge which reaches into the territory
The Little Orphan (1,252 words) [view diff] exact match in snippet view article find links to article
The Little Orphan is a 1949 American one-reel animated cartoon and the 40th Tom and Jerry cartoon, released in theaters on April 30, 1949 by Metro-Goldwyn
Moxetumomab pasudotox (1,421 words) [view diff] exact match in snippet view article find links to article
that CAT-8015 had started Phase III clinical trials. On 5 December 2008, orphan designation (EU/3/08/592) was granted by the European Commission to Medimmune
Duvelisib (721 words) [view diff] exact match in snippet view article find links to article
million payment for an FDA approval, and royalties. Duvelisib has received orphan drug designation in the United States for treatment of peripheral T-cell
Pfizer (9,689 words) [view diff] no match in snippet view article find links to article
Coordinates: 41°20′04″N 72°04′05″W / 41.3343429°N 72.06795°W / 41.3343429; -72.06795 Pfizer Inc. (/ˈfaɪzər/ FY-zər) is an American multinational pharmaceutical
Monster Study (2,089 words) [view diff] exact match in snippet view article find links to article
The Monster Study was a stuttering experiment performed on 22 orphan children in Davenport, Iowa in 1939. It was conducted by Wendell Johnson at the University
James Bond (literary character) (8,193 words) [view diff] exact match in snippet view article
his father's work as a Vickers armaments company representative. Bond is orphaned at the age of 11 when his parents are killed in a mountain climbing accident
The Devil's Hands Are Idle Playthings (1,277 words) [view diff] no match in snippet view article find links to article
"The Devil's Hands Are Idle Playthings" is the final episode in the fourth season of the American animated television series Futurama, and the finale of
Cabozantinib (1,663 words) [view diff] exact match in snippet view article find links to article
KIT), and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib was granted orphan drug status by the U.S. Food and Drug Administration (FDA) in November 2010
Lenvatinib (887 words) [view diff] exact match in snippet view article find links to article
treating thyroid cancer patients started in March 2011. Lenvatinib was granted orphan drug status for treatment of various types of thyroid cancer that do not
Entinostat (105 words) [view diff] no match in snippet view article find links to article
Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers
Neuropeptides B/W receptor 1 (1,058 words) [view diff] exact match in snippet view article find links to article
When originally discovered in 1995, these receptors had no known ligands ("orphan receptors") and were called GPR7 and GPR8, but at least three groups in
Umbralisib (788 words) [view diff] exact match in snippet view article find links to article
"Orphan Treatment of extranodal marginal zone lymphoma". U.S. Food and Drug Administration (FDA). 11 April 2019. Retrieved 5 February 2021. "Orphan Treatment
Romiplostim (562 words) [view diff] exact match in snippet view article find links to article
(immune) thrombocytopenic purpura (ITP). Romiplostim was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2003, as the chronic
Genentech (3,007 words) [view diff] no match in snippet view article find links to article
Genentech, Inc., is an American biotechnology corporation which became a subsidiary of Roche in 2009. Genentech Research and Early Development operates
GPRC5C (647 words) [view diff] exact match in snippet view article find links to article
different isoforms have been found for this gene. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000170412 -
Portrayal of James Bond in film (8,145 words) [view diff] no match in snippet view article find links to article
James Bond is a fictional character created by the British journalist and novelist Ian Fleming in 1952. The literary character appeared in a series of
Lyra Belacqua (1,472 words) [view diff] no match in snippet view article find links to article
Lyra Belacqua (/ˈlaɪrə bəˈlɑːkwə/), also known as Lyra Silvertongue, is the heroine of Philip Pullman's trilogy His Dark Materials. In His Dark Materials
Arylsulfatase B (1,817 words) [view diff] exact match in snippet view article find links to article
Galsulfase (N-acetylgalactosamine-4-sulfatase, recombinant human) was granted orphan drug designation by both the European Commission and the U.S. Food and Drug
Entrectinib (2,029 words) [view diff] exact match in snippet view article find links to article
S., entrectinib has orphan drug designation and rare pediatric disease designation for the treatment of neuroblastoma and orphan drug designation for
Fasudil (961 words) [view diff] no match in snippet view article find links to article
Fasudil (INN) is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which
GPR50 (770 words) [view diff] exact match in snippet view article find links to article
MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through
Posaconazole (661 words) [view diff] no match in snippet view article find links to article
Posaconazole, sold under the brand names Noxafil and Posanol is a triazole antifungal medication. It was approved for medical use in the United States
Altretamine (524 words) [view diff] no match in snippet view article find links to article
Altretamine (trade name Hexalen) is an antineoplastic agent. It was approved by the U.S. FDA in 1990. It is indicated for use as a single agent in the
Inuktitut Braille (759 words) [view diff] exact match in snippet view article find links to article
Commonwealth Braille and Talking Book Cooperative. The book ᐃᓕᐊᕐᔪᒃ ᓇᓄᕐᓗ The Orphan and the Polar Bear was the first (and perhaps only) work transliterated
Amanda Brugel (1,622 words) [view diff] exact match in snippet view article find links to article
series Seed (2013–2014), Marci Coates in the Space science fiction series Orphan Black (2015), Nina Gomez in the CBC comedy series Kim's Convenience (2016–2021)
Elesclomol (650 words) [view diff] exact match in snippet view article find links to article
GlaxoSmithKline as a chemotherapy adjuvant, and has received both fast track and orphan drug status from the U.S. Food and Drug Administration for the treatment
Tipifarnib (673 words) [view diff] no match in snippet view article find links to article
Tipifarnib (INN,: 213  proposed trade name Zarnestra) is a farnesyltransferase inhibitor. Farnesyltransferase inhibitors block the activity of the farnesyltransferase
Link rot (1,782 words) [view diff] exact match in snippet view article find links to article
points to its target, often called a broken or dead link (or sometimes orphan link), is a specific form of dangling pointer. The rate of link rot is a
Hannibal Lecter (6,228 words) [view diff] exact match in snippet view article find links to article
from his birth into an aristocratic family in Lithuania in 1933, to being orphaned, along with his beloved younger sister Mischa, in 1944 when a Nazi Stuka
Tolvaptan (650 words) [view diff] exact match in snippet view article find links to article
the treatment of polycystic kidney disease. The FDA granted Jynarque an orphan drug designation in April 2012, for the treatment of autosomal dominant
Thiotepa (631 words) [view diff] exact match in snippet view article find links to article
29, 2007, the European Medicines Agency (EMA) designated thiotepa as an orphan drug. On April 2, 2007, the United States FDA designated thiotepa as a conditioning
Ganaxolone (680 words) [view diff] no match in snippet view article find links to article
Ganaxolone (developmental code name CCD-1042) is an experimental drug which is under development by Marinus Pharmaceuticals for potential medical use as
Orphan School Creek (130 words) [view diff] exact match in snippet view article find links to article
33°52′58″S 151°10′34″E / 33.882663°S 151.176219°E / -33.882663; 151.176219 Orphan School Creek is a storm drain located in inner Sydney, New South Wales.
Icatibant (445 words) [view diff] exact match in snippet view article find links to article
effects of icatibant on the bradykinin B1 receptor. Icatibant received orphan drug status in Australia, the EU, Switzerland, and the US for the treatment
Jaume Collet-Serra (1,128 words) [view diff] exact match in snippet view article find links to article
producer. He is known for directing the horror films House of Wax (2005), Orphan (2009), and The Shallows (2016), as well as the Liam Neeson-led thriller
List of Marvel Comics characters: O (3,597 words) [view diff] no match in snippet view article find links to article
0–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Blackjack O'Hare is a fictional anthropomorphic hare in Marvel Comics. The character, created by
Neuromedin U receptor 1 (440 words) [view diff] exact match in snippet view article find links to article
(Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and
Tails (Sonic the Hedgehog) (3,487 words) [view diff] no match in snippet view article
Miles Prower (Japanese: マイルス パウアー, Hepburn: Mairusu Pauā), better known by his nickname Tails (テイルス, Teirusu), is a fictional character in Sega's Sonic
Rituximab (3,863 words) [view diff] no match in snippet view article find links to article
Rituximab, sold under the brand name Rituxan, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for non-Hodgkin
Asparaginase (1,933 words) [view diff] exact match in snippet view article find links to article
for asparaginase erwinia chrysanthemi (recombinant)-rywn fast track and orphan drug designations. The most common use of asparaginases is as a processing
Evinacumab (527 words) [view diff] exact match in snippet view article find links to article
Food and Drug Administration (FDA) granted the application for evinacumab orphan drug, breakthrough therapy, and priority review designations. The FDA granted
Vertex Pharmaceuticals (3,115 words) [view diff] exact match in snippet view article find links to article
executive chairman until April 2023. In 2012 ivacaftor was designated as an orphan drug, identifying cystic fibrosis as affecting fewer than 200,000 people
Evinacumab (527 words) [view diff] exact match in snippet view article find links to article
Food and Drug Administration (FDA) granted the application for evinacumab orphan drug, breakthrough therapy, and priority review designations. The FDA granted
Gemtuzumab ozogamicin (1,229 words) [view diff] no match in snippet view article find links to article
Gemtuzumab ozogamicin, sold under the brand name Mylotarg, is an antibody-drug conjugate (a drug-linked monoclonal antibody) that is used to treat acute
Brigatinib (657 words) [view diff] exact match in snippet view article find links to article
application to the US FDA on August 29, 2016. In 2016, brigatinib was granted orphan drug status by the FDA for treatment of NSCLC. In 28 April 2017, it was
Bran Stark (3,014 words) [view diff] exact match in snippet view article find links to article
Rickon go into hiding. To cement his claim on Winterfell, Theon has two orphan boys killed and their bodies burned, and passes their charred corpses off
Trabectedin (1,520 words) [view diff] exact match in snippet view article find links to article
European Commission and the U.S. Food and Drug Administration (FDA) granted orphan drug status to trabectedin for soft-tissue sarcomas and ovarian cancer.
Mogamulizumab (627 words) [view diff] no match in snippet view article find links to article
Mogamulizumab, sold under the brand name Poteligeo, is a humanized, afucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4). The U.S
Dasiglucagon (320 words) [view diff] exact match in snippet view article find links to article
for medical use in the United States in March 2021. It was designated an orphan drug in August 2017. Dasiglucagon is indicated for the treatment of severe
5th Canadian Screen Awards (493 words) [view diff] exact match in snippet view article find links to article
ceremony, the film It's Only the End of the World and the television series Orphan Black won the most awards in film and television categories, with six and
Dacomitinib (266 words) [view diff] no match in snippet view article find links to article
Dacomitinib, sold under the brand name Vizimpro, is a medication for the treatment of non-small-cell lung carcinoma (NSCLC). It is a selective and irreversible
Leatherface (4,801 words) [view diff] no match in snippet view article find links to article
Leatherface is a fictional character in The Texas Chainsaw Massacre film series created by Kim Henkel and Tobe Hooper. He first appears in The Texas Chain
Constitutive androstane receptor (2,229 words) [view diff] exact match in snippet view article find links to article
Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD (Mar 1994). "A new orphan member of the nuclear hormone receptor superfamily that interacts with a
Trehalose (1,843 words) [view diff] no match in snippet view article find links to article
Trehalose (from Turkish 'trehala' – a sugar derived from insect cocoons + -ose) is a sugar consisting of two molecules of glucose. It is also known as
Ripretinib (1,136 words) [view diff] exact match in snippet view article find links to article
fast track designations, as well as breakthrough therapy designation and orphan drug designation. The FDA granted approval of Qinlock to Deciphera Pharmaceuticals
Belantamab mafodotin (707 words) [view diff] exact match in snippet view article find links to article
(FDA) granted the application for belantamab mafodotin priority review, orphan drug designation, and breakthrough therapy designation. Belantamab mafodotin
Icatibant (445 words) [view diff] exact match in snippet view article find links to article
effects of icatibant on the bradykinin B1 receptor. Icatibant received orphan drug status in Australia, the EU, Switzerland, and the US for the treatment
Arya Stark (5,723 words) [view diff] no match in snippet view article find links to article
Arya Stark is a fictional character in American author George R. R. Martin's A Song of Ice and Fire epic fantasy novel series, and its television adaptation
Terguride (502 words) [view diff] exact match in snippet view article find links to article
attenuation of disease progression. In May 2008, terguride was granted orphan drug status for the treatment of pulmonary arterial hypertension. In May
GPR182 (1,004 words) [view diff] exact match in snippet view article find links to article
protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. When this gene was first cloned, it was proposed
Pemtumomab (159 words) [view diff] exact match in snippet view article find links to article
2009[update], it is undergoing Phase III clinical trials. It has been granted orphan drug status in Europe. Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas
Fenfluramine (2,545 words) [view diff] exact match in snippet view article find links to article
"Fenfluramine Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 25 June 2020. "Fenfluramine Orphan Drug
Mepolizumab (1,038 words) [view diff] no match in snippet view article find links to article
Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis
Wedge Antilles (1,904 words) [view diff] no match in snippet view article find links to article
Wedge Antilles is a fictional character in the Star Wars franchise. He is a supporting character portrayed by Denis Lawson in the original Star Wars trilogy
Orphan School Creek (Fairfield) (200 words) [view diff] exact match in snippet view article
Orphan School Creek is a tributary of Prospect Creek, located entirely within the City of Fairfield, NSW. It starts in Allambie Road Reserve, Bossley Park
Tails (Sonic the Hedgehog) (3,487 words) [view diff] no match in snippet view article
Miles Prower (Japanese: マイルス パウアー, Hepburn: Mairusu Pauā), better known by his nickname Tails (テイルス, Teirusu), is a fictional character in Sega's Sonic
Avapritinib (1,034 words) [view diff] exact match in snippet view article find links to article
was granted fast track designation, breakthrough therapy designation, and orphan drug designation. The FDA granted approval of Ayvakit to Blueprint Medicines
Loncastuximab tesirine (597 words) [view diff] exact match in snippet view article find links to article
response and 14% partial response). Loncastuximab tesirine was granted orphan drug designation by the U.S. Food and Drug Administration (FDA) for the
Tremelimumab (724 words) [view diff] exact match in snippet view article find links to article
Response Criteria (irRC) instead. Although it was designated in April 2015 as orphan drug status in mesothelioma, tremelimumab failed to improve lifespan in
Pitolisant (806 words) [view diff] exact match in snippet view article find links to article
U.S. Food and Drug Administration (FDA) in August 2019. It was granted orphan drug designation for the treatment of narcolepsy, fast track designation
Shelleyan Orphan (762 words) [view diff] exact match in snippet view article find links to article
Shelleyan Orphan were a British alternative music group that peaked during the 1980s and early 1990s. In 1980, Caroline Crawley and Jemaur Tayle met in
Peter Parker (Marvel Cinematic Universe) (5,169 words) [view diff] exact match in snippet view article
on which he had collaborated with Joe Simon in the 1950s, in which an orphaned boy living with an old couple finds a magic ring that granted him superhuman
Venetoclax (2,324 words) [view diff] exact match in snippet view article find links to article
and accelerated approval along with breakthrough therapy designation and orphan drug designation. Venetoclax was approved for use in the European Union
Orphan: First Kill (448 words) [view diff] exact match in snippet view article find links to article
Orphan: First Kill is an upcoming American horror film, directed by William Brent Bell, from a screenplay by David Coggeshall. It is a prequel to the 2009
Brain-specific angiogenesis inhibitor 3 (524 words) [view diff] exact match in snippet view article find links to article
and may also play a role in angiogenesis. }} The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI
Tucatinib (1,447 words) [view diff] exact match in snippet view article find links to article
application for tucatinib priority review, breakthrough therapy, fast track, and orphan drug designations. The FDA granted approval of Tukysa to Seattle Genetics
Vorinostat (1,095 words) [view diff] no match in snippet view article find links to article
Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds
Echovirus (405 words) [view diff] exact match in snippet view article find links to article
enteric disease in humans. The name is derived from "enteric cytopathic human orphan virus". These viruses were originally not associated with disease, but many
Orion Arm (1,012 words) [view diff] exact match in snippet view article find links to article
star-forming regions) have been shown that the Local arm appears to be an orphan segment of an arm between the Sagittarius and Perseus arms that wraps around
GPR75 (312 words) [view diff] exact match in snippet view article find links to article
proteins upon the binding of a ligand. GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study
Leonard Starr (1,195 words) [view diff] exact match in snippet view article find links to article
known for creating the newspaper comic strip On Stage and reviving Little Orphan Annie. Born October 28, 1925, in New York City, Starr graduated from Manhattan's
Orochimaru (Naruto) (3,791 words) [view diff] no match in snippet view article
Orochimaru (大蛇丸) is a fictional character from Naruto, a manga series created by Masashi Kishimoto. In the anime and manga, Orochimaru is a former ninja
Ruxolitinib (1,401 words) [view diff] no match in snippet view article find links to article
Ruxolitinib, sold under the brand names Jakafi and Jakavi, is a medication for the treatment of intermediate or high-risk myelofibrosis, a type of myeloproliferative
Misty (Pokémon) (1,961 words) [view diff] no match in snippet view article
Misty, known in Japan as Kasumi (カスミ), is a fictional character in the Pokémon franchise owned by Nintendo and created by Satoshi Tajiri. She has appeared
Nivolumab (4,110 words) [view diff] no match in snippet view article find links to article
Nivolumab, sold under the brand name Opdivo, is a medication used to treat a number of types of cancer. This includes melanoma, lung cancer, malignant
Roche (4,290 words) [view diff] no match in snippet view article find links to article
Coordinates: 47°33′31″N 7°36′22″E / 47.558624°N 7.606018°E / 47.558624; 7.606018 F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational
Tom and Jerry filmography (821 words) [view diff] exact match in snippet view article find links to article
and beyond. Fifth cartoon where Tom and Jerry both lose. 40 The Little Orphan April 30, 1949 In this Thanksgiving short, Jerry and Nibbles dine on Thanksgiving
Clark Kent (DC Extended Universe) (5,610 words) [view diff] no match in snippet view article
Clark Joseph Kent, also known by his birth name Kal-El or superhero persona Superman, is a fictional character and a superhero in the DC Extended Universe
Quasimodo (2,972 words) [view diff] exact match in snippet view article find links to article
where he is found abandoned in Notre Dame (on the foundlings' bed, where orphans and unwanted children are left to public charity) on Quasimodo Sunday,
Carboprost (557 words) [view diff] no match in snippet view article find links to article
Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α)
Capmatinib (950 words) [view diff] exact match in snippet view article find links to article
approval program and granted the application for capmatinib priority review, orphan drug, and breakthrough therapy designations and granted the approval of
Rev-ErbA beta (2,030 words) [view diff] exact match in snippet view article find links to article
interaction with the transcriptional activator Retinoic Acid Receptor-related Orphan Receptor (ROR) and a direct repeat 2 element of RORE known as RevDR2. The
Capmatinib (950 words) [view diff] exact match in snippet view article find links to article
approval program and granted the application for capmatinib priority review, orphan drug, and breakthrough therapy designations and granted the approval of
Roche (4,290 words) [view diff] no match in snippet view article find links to article
Coordinates: 47°33′31″N 7°36′22″E / 47.558624°N 7.606018°E / 47.558624; 7.606018 F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational
Nebula (Marvel Cinematic Universe) (3,146 words) [view diff] no match in snippet view article
Nebula is a fictional character in the Marvel Cinematic Universe (MCU) media franchise, portrayed by Karen Gillan, based on the Marvel Comics character
Receptor tyrosine kinase-like orphan receptor (85 words) [view diff] exact match in snippet view article find links to article
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in
Clark Kent (DC Extended Universe) (5,610 words) [view diff] no match in snippet view article
Clark Joseph Kent, also known by his birth name Kal-El or superhero persona Superman, is a fictional character and a superhero in the DC Extended Universe
GPR75 (312 words) [view diff] exact match in snippet view article find links to article
proteins upon the binding of a ligand. GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study
GPRC5D (224 words) [view diff] exact match in snippet view article find links to article
function of this gene has not yet been determined. Retinoic acid-inducible orphan G protein-coupled receptor GRCh38: Ensembl release 89: ENSG00000111291 -
Edward Cullen (3,679 words) [view diff] no match in snippet view article find links to article
Edward Cullen (né Edward Anthony Masen, Jr.) is a fictional character in Stephenie Meyer's Twilight series. He is featured in the books Twilight, New Moon
GPR35 (1,124 words) [view diff] exact match in snippet view article find links to article
including the crypts of Lieberkühn. Although GPR35 is still considered an orphan receptor, there have been attempts to deorphanize it by identifying endogenous
Charlie Dog (869 words) [view diff] exact match in snippet view article find links to article
two more Charlie Dog/Porky Pig cartoons in 1949: Awful Orphan (29 January) and Often an Orphan (13 August). Jones also starred Charlie without Porky in
Orion Arm (1,012 words) [view diff] exact match in snippet view article find links to article
star-forming regions) have been shown that the Local arm appears to be an orphan segment of an arm between the Sagittarius and Perseus arms that wraps around
Belzutifan (481 words) [view diff] no match in snippet view article find links to article
Belzutifan, sold under the brand name Welireg, is a medication used for the treatment of von Hippel–Lindau disease-associated renal cell carcinoma. It
Misty (Pokémon) (1,961 words) [view diff] no match in snippet view article
Misty, known in Japan as Kasumi (カスミ), is a fictional character in the Pokémon franchise owned by Nintendo and created by Satoshi Tajiri. She has appeared
Treprostinil (1,571 words) [view diff] exact match in snippet view article find links to article
Patient Package Insert. United Therapeutics Corp. 2013. Rare Disease and Orphan Drug Designated Approvals 2013 "Orenitram" (PDF). Full Prescribing Information
Carboprost (557 words) [view diff] no match in snippet view article find links to article
Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α)
Tetrahydrobiopterin (2,481 words) [view diff] no match in snippet view article find links to article
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation
Oswald Cobblepot (Batman Returns) (1,862 words) [view diff] no match in snippet view article
Oswald Chesterfield Cobblepot, also known as the Penguin, is a fictional character and the main antagonist of the 1992 superhero film Batman Returns, directed
Frodo Baggins (4,561 words) [view diff] no match in snippet view article find links to article
Frodo Baggins is a fictional character in J. R. R. Tolkien's writings, and one of the protagonists in The Lord of the Rings. Frodo is a hobbit of the Shire
Istiratumab (78 words) [view diff] exact match in snippet view article find links to article
ErbB3. It is in development by Merrimack Pharmaceuticals and was awarded orphan drug status for pancreatic cancer. Alternative Names: MM-141. "Istiratumab
Estetrol (1,278 words) [view diff] no match in snippet view article find links to article
Estetrol (E4), or oestetrol, is a weak estrogen steroid hormone, which is found in detectable levels only during pregnancy in humans. It is produced exclusively
Jason Voorhees (12,262 words) [view diff] exact match in snippet view article find links to article
Jason, Ari Lehman, who had received a part in Sean Cunningham's Manny's Orphans, arrived to read for the character of Jack. Before he could get started
Metreleptin (511 words) [view diff] no match in snippet view article find links to article
Metreleptin, sold under the brand name Myalept among others, is a synthetic analog of the hormone leptin used to treat various forms of dyslipidemia. It
Chlormethine (1,692 words) [view diff] no match in snippet view article find links to article
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard
Pregnane X receptor (1,963 words) [view diff] exact match in snippet view article find links to article
Watson MA, Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene
Actelion (2,516 words) [view diff] exact match in snippet view article find links to article
Actelion focuses on the manufacture of drugs that treat rare diseases and orphan diseases. Some of the drugs it has produced have been used to treat patients
Ixazomib (1,570 words) [view diff] exact match in snippet view article find links to article
can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative. The
Busulfan (1,216 words) [view diff] no match in snippet view article find links to article
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific
Armenian Orphan Rug (2,009 words) [view diff] exact match in snippet view article find links to article
The Armenian Orphan Rug, also known as the Ghazir Orphans' Rug, is an Armenian styled carpet woven by orphans of the Armenian genocide in Ghazir, Lebanon
GPR15 (1,464 words) [view diff] exact match in snippet view article find links to article
GPR15 is a class A orphan G protein-coupled receptor (heterotrimeric guanine nucleotide-binding protein, GPCR). The GPR15 gene is localized at chromosome
Azacitidine (1,685 words) [view diff] no match in snippet view article find links to article
Azacitidine, sold under the brand name Vidaza among others, is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative
Huerfano Butte (357 words) [view diff] exact match in snippet view article find links to article
Walsenburg in Huerfano County, Colorado, United States. Named Huérfano (English: orphan) by early Spanish explorers, it rises above the south side of the Huerfano
Mecasermin rinfabate (1,225 words) [view diff] no match in snippet view article find links to article
Mecasermin rinfabate (INN, USAN) (brand name Iplex), also known as rhIGF-1/rhIGFBP-3, is a drug consisting of recombinant human insulin-like growth factor
Sansa Stark (6,899 words) [view diff] no match in snippet view article find links to article
Sansa Stark is a fictional character in the A Song of Ice and Fire series of epic fantasy novels by American author George R. R. Martin, and its television
List of Drawn Together episodes (173 words) [view diff] exact match in snippet view article find links to article
Musical number: "The Board of Education" and "Fire the Load" 10 3 "Little Orphan Hero" Ray Claffey Erik Sommers November 2, 2005 (2005-11-02) 203 After discovering
Novo Nordisk (2,038 words) [view diff] no match in snippet view article find links to article
Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd, Denmark, with production facilities in eight countries, and
Pembrolizumab (5,660 words) [view diff] exact match in snippet view article find links to article
studies to ensure that the results are valid. Pembrolizumab was granted orphan drug designation for SCLC in October 2017. In June 2018, the US FDA approved
Michiel Huisman (1,896 words) [view diff] exact match in snippet view article find links to article
television such as Liam McGuinnis on Nashville (2012–14), Cal Morrison on Orphan Black (2014–15) and Alex Sokolov in the first season of The Flight Attendant
Biogen (3,255 words) [view diff] exact match in snippet view article find links to article
hemophilia B 2021 1993 Also approved in Canada and Australia. Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization
Krallice (1,036 words) [view diff] exact match in snippet view article find links to article
year they released a single titled Traditional, as well as the cover EP Orphans of Sickness. Krallice independently released their fourth full-length album
Sorafenib (2,450 words) [view diff] no match in snippet view article find links to article
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary
Pazopanib (1,271 words) [view diff] no match in snippet view article find links to article
Pazopanib, sold under the brand name Votrient, is an anti-cancer medication marketed worldwide by Novartis. It is a potent and selective multi-targeted
ViroPharma (766 words) [view diff] exact match in snippet view article find links to article
Makiko (11 November 2013). "Shire Buys ViroPharma for $4.2 Billion to Add Orphan Drug". Bloomberg. Pollack, Andrew (9 November 2005). "Crucial Antibiotic
F-15,599 (568 words) [view diff] exact match in snippet view article find links to article
gene expression underlies Rett syndrome, a debilitating neurodevelopmental orphan disease. F-15,599 was discovered and initially developed by Pierre Fabre
Annie (1999 film) (2,225 words) [view diff] exact match in snippet view article
Martin Charnin, and Thomas Meehan, which in turn is based on the 1924 Little Orphan Annie comic strip by Harold Gray. It was directed by Rob Marshall, written
Crizanlizumab (574 words) [view diff] exact match in snippet view article find links to article
crizanlizumab-tmca priority review, breakthrough therapy designation, and orphan drug designation. The FDA granted approval of Adakveo to Novartis. "AusPAR:
John Hunt Morgan (3,246 words) [view diff] no match in snippet view article find links to article
John H. Morgan (June 1, 1825 – September 4, 1864) was a Confederate general in the American Civil War of 1861-1865. In April 1862, Morgan raised the 2nd
Thomas John Barnardo (1,711 words) [view diff] exact match in snippet view article find links to article
Victorian London. Many of these children were not only impoverished, but orphaned, as the result of a recent cholera outbreak. For those unable to afford
Cromoglicic acid (1,147 words) [view diff] no match in snippet view article find links to article
Cromoglicic acid (INN) — also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate — is traditionally described as a mast cell stabilizer
Michiel Huisman (1,896 words) [view diff] exact match in snippet view article find links to article
television such as Liam McGuinnis on Nashville (2012–14), Cal Morrison on Orphan Black (2014–15) and Alex Sokolov in the first season of The Flight Attendant
Pregnane X receptor (1,963 words) [view diff] exact match in snippet view article find links to article
Watson MA, Willson TM, Moore JT, Kliewer SA (September 1998). "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene
Nitisinone (858 words) [view diff] exact match in snippet view article find links to article
nitisinone being brought to market as an orphan drug Swedish Orphan International, which was later acquired by Swedish Orphan Biovitrum (Sobi).[citation needed]
Rucaparib (1,099 words) [view diff] exact match in snippet view article find links to article
pretreated advanced ovarian cancer. In the European Union it was designated an orphan medicinal product on 10 October 2012. On 22 March 2018, the Committee for
Adam Johnson (writer) (1,419 words) [view diff] exact match in snippet view article
and short story writer. He won the Pulitzer Prize for his 2012 novel, The Orphan Master's Son, and the National Book Award for his 2015 story collection
Park County, Colorado (1,116 words) [view diff] exact match in snippet view article find links to article
been and is the location of several important mines, including the defunct Orphan Boy, which was discovered near Alma in 1861 and produced gold, silver, lead
Runaway (dependent) (1,597 words) [view diff] no match in snippet view article
A runaway is a minor or (depending upon the local jurisdiction) a person under a specified age, who has left their parents or legal guardians without permission
Jad-bal-ja (393 words) [view diff] exact match in snippet view article find links to article
Lion (1922 serial, 1923 novel), in which the ape-man discovers him as an orphaned cub and raises and trains him. He is named for the color of his coat, Jad-bal-ja
Time's Orphan (811 words) [view diff] exact match in snippet view article find links to article
"Time's Orphan" is the 148th episode of the syndicated American science fiction television series Star Trek: Deep Space Nine, the 24th episode of the sixth
3rd Canadian Screen Awards (206 words) [view diff] exact match in snippet view article find links to article
13 nominations, while on the television side the science fiction series Orphan Black also received 13 nominations. The awards ceremony were hosted by Andrea
TLX (935 words) [view diff] exact match in snippet view article find links to article
"Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX". Molecular and Cellular Biology. 20 (23): 8731–9.
Brentuximab vedotin (1,800 words) [view diff] no match in snippet view article find links to article
Brentuximab vedotin (INN; trade name Adcetris) is an antibody-drug conjugate medication used to treat relapsed or refractory Hodgkin lymphoma (HL) and
Eltrombopag (1,033 words) [view diff] no match in snippet view article find links to article
Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe
Batman and Robin Eternal (1,124 words) [view diff] exact match in snippet view article find links to article
one of Mother's agents calling himself the Orphan. Cassandra Cain saves her, then chases after the Orphan. Dick meets Harper and her roommate Stephanie
Omacetaxine mepesuccinate (773 words) [view diff] no match in snippet view article find links to article
Omacetaxine mepesuccinate (INN, trade names Synribo ), formerly named as homoharringtonine or HHT, is a pharmaceutical drug substance that is indicated
Bortezomib (2,136 words) [view diff] no match in snippet view article find links to article
Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma. This
Laura Dern (2,834 words) [view diff] exact match in snippet view article find links to article
She received an Academy Award nomination for her portrayal of the titular orphan in the drama film Rambling Rose (1991) and achieved international recognition
Dick Grayson (1989 film series character) (2,265 words) [view diff] no match in snippet view article
Dick Grayson, better known by his superhero alias Robin, is a fictional character from Joel Schumacher's superhero films Batman Forever (1995) and Batman
Naxitamab (569 words) [view diff] exact match in snippet view article find links to article
the application for naxitamab priority review, breakthrough therapy, and, orphan drug designations. The FDA issued a priority review voucher for this rare
Iloprost (1,241 words) [view diff] no match in snippet view article find links to article
Iloprost is a medication used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels
KiSS1-derived peptide receptor (1,927 words) [view diff] exact match in snippet view article find links to article
suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". The Journal of Biological Chemistry.
Bombesin-like receptor 3 (823 words) [view diff] exact match in snippet view article find links to article
therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor. GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
Mikołaj Krzysztof "the Orphan" Radziwiłł (1,075 words) [view diff] exact match in snippet view article find links to article
Radvila Našlaitėlis) (2 Augustus 1549 – 28 February 1616) and nicknamed "the Orphan" (Lithuanian: Našlaitėlis, Polish: Sierotka), was a Polish–Lithuanian nobleman
Peter Quill (Marvel Cinematic Universe) (3,014 words) [view diff] no match in snippet view article
Peter Quill, also known by his alias Star-Lord, is a fictional character portrayed primarily by Chris Pratt in the Marvel Cinematic Universe (MCU) media
Gaara (3,846 words) [view diff] no match in snippet view article find links to article
Gaara of the Desert (我愛羅) is a character in the Naruto manga and anime series created by Masashi Kishimoto. Originally debuting as an antagonist, Gaara
Sylvie (Marvel Cinematic Universe) (4,047 words) [view diff] no match in snippet view article
Sylvie Laufeydottir (born Loki) is a fictional character portrayed by Sophia Di Martino in the Marvel Cinematic Universe (MCU) media franchise, partially
Carmustine (569 words) [view diff] no match in snippet view article find links to article
Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy. It is a nitrogen mustard β-chloro-nitrosourea compound
Treosulfan (554 words) [view diff] exact match in snippet view article find links to article
fludarabine) were alive 3 months after their transplant. On 23 February 2004, orphan designation (EU/3/04/186) was granted by the European Commission to medac
Time Squad (2,367 words) [view diff] exact match in snippet view article find links to article
encounter Otto Osworth (Pamela Adlon), an 8-year-old boy who happens to be an orphan from the 21st century, he is quickly recruited and added to the team. Otto
Romidepsin (1,458 words) [view diff] exact match in snippet view article find links to article
designation from the FDA for the treatment of cutaneous T-cell lymphoma, and orphan drug status from the FDA and the European Medicines Agency for the same
Bruce Wayne (Gotham) (2,808 words) [view diff] exact match in snippet view article
finale (with Mazouz providing the character's voice). Bruce Wayne is the orphaned son of Thomas and Martha Wayne, who are murdered at the beginning of the
Matt Frewer (986 words) [view diff] exact match in snippet view article find links to article
Eureka (2006–2012) and Doctor Leekie in the Canadian science fiction drama Orphan Black (2013–2017). Frewer's more recent performances include a portrayal
Margo Martindale (1,637 words) [view diff] exact match in snippet view article find links to article
Rocketeer, ...First Do No Harm, Eye of God, Win Win, Marvin's Room, Forged, Orphan, The Savages, Hannah Montana: The Movie, August: Osage County, and Paris
Winston Smith (Nineteen Eighty-Four) (827 words) [view diff] no match in snippet view article
Winston Smith is a fictional character and the protagonist of George Orwell's dystopian 1949 novel Nineteen Eighty-Four. The character was employed by
Binandere language (180 words) [view diff] exact match in snippet view article find links to article
(Guhu-Samane burisi eetaqu ‘turn over, turn s.th. around’) *mbeŋga-masi ‘orphan’, ‘widow and child’ (Suena boga masa ‘destitute widow and child’) *pu +
Camille Montes (758 words) [view diff] no match in snippet view article find links to article
Camille Montes Rivero is a fictional character in the 2008 James Bond film Quantum of Solace portrayed by actress Olga Kurylenko. Camille is a Bolivian
Paromomycin (1,358 words) [view diff] no match in snippet view article find links to article
Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection.
Sanofi (8,064 words) [view diff] exact match in snippet view article find links to article
headquartered in Cambridge, Massachusetts specializes in the treatment of orphan diseases, renal diseases, endocrinology, oncology and biosurgery. In January
Takeda Pharmaceutical Company (2,419 words) [view diff] no match in snippet view article find links to article
The Takeda Pharmaceutical Company Limited (武田薬品工業株式会社, Takeda Yakuhin Kōgyō kabushiki gaisha) [takeꜜda jakɯçiŋ koꜜːɡʲoː] is a Japanese multinational pharmaceutical
Inigo Montoya (989 words) [view diff] no match in snippet view article find links to article
Inigo Montoya is a fictional character in William Goldman's 1973 novel The Princess Bride. In Rob Reiner's 1987 film adaptation, he was portrayed by Mandy
Rovalpituzumab tesirine (395 words) [view diff] no match in snippet view article find links to article
Rovalpituzumab tesirine (Rova-T) is an experimental antibody-drug conjugate targeting the protein DLL3 on tumor cells. It was originally developed by Stemcentrx
GPR3 (2,174 words) [view diff] exact match in snippet view article find links to article
neurons, helping symptoms of Alzheimer’s disease. GPR3 is largely known as an orphan G protein-coupled receptor. Even though is does not have any endogenous
Daddy Warbucks (1,414 words) [view diff] exact match in snippet view article find links to article
Oliver "Daddy" Warbucks is a fictional character from the comic strip Little Orphan Annie. He made his first appearance in the New York Daily News in the Annie
Lanadelumab (1,004 words) [view diff] exact match in snippet view article find links to article
this trial, Lanadelumab was given Priority Review, Breakthrough Therapy, Orphan Drug designation by the FDA. The phase 3 HELP study evaluated efficacy and
GPR55 (1,697 words) [view diff] exact match in snippet view article find links to article
a relevant role in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in oncology
Neuropeptide S receptor (1,698 words) [view diff] exact match in snippet view article find links to article
membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous
Otelixizumab (682 words) [view diff] exact match in snippet view article find links to article
failed to show efficacy of the treatment. Otelixizumab has been granted "orphan drug" status by the U.S. Food and Drug Administration. As a monoclonal antibody
Eribulin (1,981 words) [view diff] exact match in snippet view article find links to article
population, Eisai was able to file a New Drug Application (NDA) under the orphan and rare disease designation. On January 28, 2016, the U.S. Food and Drug
The Shakespeare Stealer (614 words) [view diff] exact match in snippet view article find links to article
place in the Elizabethan-era England, it recounts the story of Widge, an orphan whose master sends him to steal Hamlet from The Lord Chamberlain's Men.
Hefner (band) (1,093 words) [view diff] exact match in snippet view article
Hefner Soul - Too Pure - 1998 The Hefner Heart - Acuarela Discos - 1999 Orphan Songs - Everlasting Records - 1999 Revelations - Too Pure - 1999 The Hefner
Lintuzumab (505 words) [view diff] exact match in snippet view article find links to article
Administration and the European Medicines Agency had granted lintuzumab orphan drug status for treatment of AML and myelodysplastic syndromes. Seattle
Peaches (musician) (3,434 words) [view diff] exact match in snippet view article
Translation. Her music has also been featured on television shows such as Orphan Black, Lost Girl, The L Word, South Park, Skam, The Handmaid's Tale, 30
The Shakespeare Stealer (614 words) [view diff] exact match in snippet view article find links to article
place in the Elizabethan-era England, it recounts the story of Widge, an orphan whose master sends him to steal Hamlet from The Lord Chamberlain's Men.
Elotuzumab (1,210 words) [view diff] no match in snippet view article find links to article
Elotuzumab, sold under the brand name Empliciti, is a humanized IgG1 monoclonal antibody medication used in combination with lenalidomide and dexamethasone
Liver X receptor (2,765 words) [view diff] exact match in snippet view article find links to article
cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands
Rydia (1,152 words) [view diff] no match in snippet view article find links to article
Rydia of Mist (ミストのリディア, Misuto no Ridia) is a fictional character in the Final Fantasy series. She appears in Final Fantasy IV as one of its protagonists
John Fawcett (director) (479 words) [view diff] exact match in snippet view article
director for the award-winning BBC America and Space sci-fi television series Orphan Black. Fawcett began his career making commercials before moving on to direct
Rifampicin (4,814 words) [view diff] no match in snippet view article find links to article
Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), Mycobacterium avium
ROR2 (1,121 words) [view diff] exact match in snippet view article find links to article
brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
V-erbA-related gene (1,017 words) [view diff] exact match in snippet view article find links to article
Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear
Amatuximab (954 words) [view diff] exact match in snippet view article find links to article
amatuximab orphan drug status for use in malignant pleural mesothelioma in November 2012, and the European Commission soon followed granting orphan drug status
Silly Symphony (1,907 words) [view diff] exact match in snippet view article find links to article
to this include Three Little Pigs, The Tortoise and the Hare, and Three Orphan Kittens, which all had sequels). The series is notable for its innovation
Margetuximab (524 words) [view diff] exact match in snippet view article find links to article
gastric cancer and esophageal cancer.[needs update] In June 2020, it received orphan drug designation from the U.S. Food and Drug Administration (FDA). Efficacy
Eren Yeager (5,109 words) [view diff] no match in snippet view article find links to article
Eren Yeager (Japanese: エレン・イェーガー, Hepburn: Eren Yēgā), named Eren Jaeger in the subtitled and dubbed versions of the anime, is a fictional character and
Cannabidiol (10,270 words) [view diff] exact match in snippet view article find links to article
Sjögren S, Hjorth S, Hermansson NO, Leonova J, et al. (December 2007). "The orphan receptor GPR55 is a novel cannabinoid receptor". British Journal of Pharmacology
Small nucleolar RNA (3,575 words) [view diff] exact match in snippet view article find links to article
loops in the snoRNA sequence. However, there are increasing numbers of 'orphan' guides without any known RNA targets, which suggests that there might be
Germ cell nuclear factor (917 words) [view diff] exact match in snippet view article find links to article
Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated
Iva Toguri D'Aquino (2,849 words) [view diff] exact match in snippet view article find links to article
during World War II on The Zero Hour radio show. Toguri called herself "Orphan Ann", but she quickly became inaccurately identified with the name "Tokyo
Harold Gray (1,129 words) [view diff] exact match in snippet view article find links to article
cartoonist, best known as the creator of the newspaper comic strip Little Orphan Annie. Harold Gray was born in Kankakee, Illinois on January 20, 1894, to
STI College (691 words) [view diff] exact match in snippet view article find links to article
administration, and computer science. The acronym STI has been declared as an orphan initialism after their name change in 2006. STI uses a trimester calendar
GPR1 (588 words) [view diff] exact match in snippet view article find links to article
PMC 2224232. PMID 18165312. Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication
Inebilizumab (890 words) [view diff] exact match in snippet view article find links to article
and Drug Administration (FDA) granted the application for inebilizumab orphan drug designation and granted approval of Uplizna to Viela Bio. Inebilizumab
Fidaxomicin (1,165 words) [view diff] no match in snippet view article find links to article
Fidaxomicin, sold under the brand name Dificid among others, is the first member of a class of narrow spectrum macrocyclic antibiotic drugs called tiacumicins
Tacrolimus (3,890 words) [view diff] no match in snippet view article find links to article
Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection
Cladribine (3,899 words) [view diff] exact match in snippet view article find links to article
pharmaceutical companies were interested in selling the drug because HCL was an orphan disease, so Beutler's lab synthesised and packaged it and supplied it to
Maniac Magee (1,700 words) [view diff] exact match in snippet view article find links to article
Exploring themes of racism and inequality, it follows the story of an orphan boy looking for a home in the fictional town of Two Mills. Two Mills is
Neuropeptide S receptor (1,698 words) [view diff] exact match in snippet view article find links to article
membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous
Clear Paddock Creek (161 words) [view diff] exact match in snippet view article find links to article
Clear Paddock Creek is a tributary of Orphan School Creek, which in turn, is a tributary of Prospect Creek, located in the City of Fairfield, NSW. It flows
Rhoticity in English (8,718 words) [view diff] exact match in snippet view article find links to article
as boss–bourse. Specifically, the phonemic merger of the words often and orphan was a running gag in the Gilbert and Sullivan musical, The Pirates of Penzance
Lanadelumab (1,004 words) [view diff] exact match in snippet view article find links to article
this trial, Lanadelumab was given Priority Review, Breakthrough Therapy, Orphan Drug designation by the FDA. The phase 3 HELP study evaluated efficacy and
Panobinostat (1,178 words) [view diff] no match in snippet view article find links to article
Panobinostat, sold under the brand name Farydak, is a medication used for the treatment of various cancers. It is a hydroxamic acid and acts as a non-selective
Rifapentine (961 words) [view diff] exact match in snippet view article find links to article
made from rifampicin.[medical citation needed] Rifapentine was granted orphan drug designation by the FDA in June 1995, and by the European Commission
Baxter International (3,523 words) [view diff] no match in snippet view article find links to article
Baxter International Inc. is an American multinational health care company with headquarters in Deerfield, Illinois. The company primarily focuses on products
Heidi (1937 film) (1,300 words) [view diff] exact match in snippet view article
children's story of the same name. The film stars Shirley Temple as the titular orphan, who is taken from her grandfather to live as a companion to Klara, a spoiled
4th Canadian Screen Awards (372 words) [view diff] exact match in snippet view article find links to article
Ari Millen, Orphan Black Aaron Poole, Strange Empire Adrian Holmes, 19-2 Ben Bass, Rookie Blue Jared Keeso, 19-2 Tatiana Maslany, Orphan Black Jennie
New York City draft riots (4,579 words) [view diff] exact match in snippet view article find links to article
various abolitionists or sympathizers, many black homes, and the Colored Orphan Asylum at 44th Street and Fifth Avenue, which was burned to the ground.
GPR77 (697 words) [view diff] exact match in snippet view article find links to article
1016/S0161-5890(00)00067-5. PMID 11090875. Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a
GPR42 (227 words) [view diff] exact match in snippet view article find links to article
PMID 15684720. Brown AJ, Goldsworthy SM, Barnes AA, et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate
Brain Powerd (2,323 words) [view diff] exact match in snippet view article find links to article
discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies"
GPR20 (195 words) [view diff] exact match in snippet view article find links to article
Yokomizo T, Shimizu T, Nakamura M (May 2008). "Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins"
CCH Pounder (1,075 words) [view diff] exact match in snippet view article find links to article
Joon (1993), Demon Knight (1995), Face/Off (1997), End of Days (1999), Orphan (2009), Avatar (2009), The Mortal Instruments: City of Bones (2013), and
Special-purpose entity (1,324 words) [view diff] exact match in snippet view article find links to article
defeat the point of the securitization. Therefore, many SPEs are set up as 'orphan' companies with their shares settled on charitable trust and with professional
Linsitinib (279 words) [view diff] exact match in snippet view article find links to article
proliferation and induces tumor cell apoptosis. Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012. Phase II clinical
Raymond Ablack (1,116 words) [view diff] exact match in snippet view article find links to article
2016. He is also known for his supporting roles in the television series Orphan Black (2013–2016), Narcos (2017), Shadowhunters (2016–2018), Burden of Truth
Jimmy Bennett (753 words) [view diff] exact match in snippet view article find links to article
Daddy Day Care, Hostage, The Amityville Horror, Poseidon, Evan Almighty, Orphan, Shorts, and as young James T. Kirk in the 2009 film Star Trek. He also
Tislelizumab (446 words) [view diff] no match in snippet view article find links to article
Tislelizumab (BGB-A317) is a humanized monoclonal antibody directed against PD-1. It prevents PD-1 from binding to the ligands PD-L1 and PD-L2 (hence it
Doctor Who (series 12) (4,958 words) [view diff] exact match in snippet view article
"Spyfall, Part 2". James Buckley appeared in "Orphan 55" as Nevi. Laura Fraser also appeared in "Orphan 55" as Kane, as did Julia Foster as Vilma. Goran
Melatonin (9,978 words) [view diff] no match in snippet view article find links to article
Melatonin is a hormone primarily released by the pineal gland at night, and has long been associated with control of the sleep–wake cycle. As a dietary
Comic Strip Classics (146 words) [view diff] exact match in snippet view article find links to article
Goldberg’s Inventions Toonerville Folks Gasoline Alley Barney Google Little Orphan Annie Popeye Blondie Dick Tracy Alley Oop Nancy Flash Gordon Li'l Abner
William Matthews (priest) (7,413 words) [view diff] exact match in snippet view article
and president of St. Vincent's Female Orphan Asylum and the co-founder and president of St. Joseph's Male Orphan Asylum. He was born into a prominent Maryland
Naruto Uzumaki (12,828 words) [view diff] exact match in snippet view article find links to article
felt it was something common in Japanese series. Introduced as a young orphan boy of 12 years with blond, spiky hair and blue eyes, Naruto Uzumaki graduates
Squall Leonhart (4,279 words) [view diff] exact match in snippet view article find links to article
in an orphanage with the other playable characters, except Rinoa. The orphans were cared for by Edea; although Squall remembers little about his past
GPR142 (225 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Children's Aid Society (1,536 words) [view diff] exact match in snippet view article find links to article
adults. Brace was appalled by the thousands of abandoned, abused, and orphaned children living in the slums and on the streets of New York at the time
Spectrum Pharmaceuticals (504 words) [view diff] no match in snippet view article find links to article
Spectrum Pharmaceuticals is an American biopharmaceutical company. The company is located in Irvine, California. Spectrum develops and markets drugs for
Quincy, M.E. (2,182 words) [view diff] exact match in snippet view article find links to article
than the human instrument behind the guns), autism, Tourette's syndrome, orphan drugs, the dangers of punk rock, and anorexia, among others. Quincy, M.E
Qi'ra (2,558 words) [view diff] exact match in snippet view article find links to article
Wars Anthology film Solo: A Star Wars Story, Qi'ra is introduced as an orphaned street thief living on the shipbuilding world of Corellia. She and her
Neuropeptides B/W receptor 2 (461 words) [view diff] exact match in snippet view article find links to article
(2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32
Nilotinib (1,675 words) [view diff] no match in snippet view article find links to article
Nilotinib, sold under the brand name Tasigna marketed worldwide by Novartis, is a medication used to treat chronic myelogenous leukemia (CML) which has
Pyroglutamylated RFamide peptide receptor (610 words) [view diff] exact match in snippet view article find links to article
"Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10
Street children (6,169 words) [view diff] exact match in snippet view article find links to article
them more willing to force their children to the streets. For example, orphans are given financial benefits, but if they live in state-run facilities
Vegeta (6,285 words) [view diff] no match in snippet view article find links to article
Vegeta (Japanese: ベジータ, Hepburn: Bejīta) (/vəˈdʒiːtə/ və-JEE-tə), also known as Prince Vegeta (ベジータ王子, Bejīta-ōji) or alternatively styled as Vegeta IV
Huerfano County, Colorado (1,236 words) [view diff] exact match in snippet view article find links to article
Walsenburg. The county, whose name comes from the Spanish huérfano meaning "orphan", was named for the Huerfano Butte, a local landmark. The area of Huerfano
Ibrutinib (2,500 words) [view diff] no match in snippet view article find links to article
Ibrutinib, sold under the brand name Imbruvica among others, is a small molecule drug that inhibits B-cell proliferation and survival by irreversibly binding
TLX3 (824 words) [view diff] exact match in snippet view article find links to article
is encoded by the TLX3 gene. RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members
GPR139 (341 words) [view diff] exact match in snippet view article find links to article
(2005). "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system". Biochem
Karlani (251 words) [view diff] exact match in snippet view article find links to article
The legend of Karlani in the folklore says: "In his infancy he became an orphan and after losing his family he alone survived and was adopted by the Ormur
Olaparib (1,885 words) [view diff] no match in snippet view article find links to article
Olaparib, sold under the brand name Lynparza, is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a
Ranirestat (298 words) [view diff] exact match in snippet view article find links to article
neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin. It has been granted orphan drug status. The drug is to be used orally. A Canadian Phase III clinical
Anne Shirley (7,612 words) [view diff] exact match in snippet view article find links to article
had made as a young girl about two siblings who were mistakenly sent an orphan girl instead of the boy they had requested, yet decided to keep her. She
GPCR neuropeptide receptor (261 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Sacituzumab govitecan (1,887 words) [view diff] exact match in snippet view article find links to article
small cell lung cancer, and metastatic triple-negative breast cancer. Orphan drug status was granted for small cell lung cancer and pancreatic cancer
Ivacaftor (3,047 words) [view diff] exact match in snippet view article find links to article
M. Orenstein; Carlos E. Milla (2 October 2013). "Viewpoint: Pricing for Orphan Drugs: Will the Market Bear What Society Cannot?". JAMA. 310 (13): 1343–1344
Pharmaceutical industry (11,470 words) [view diff] exact match in snippet view article find links to article
benefit to society. There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases
Scenic World (974 words) [view diff] exact match in snippet view article find links to article
Scenic World began building a roller coaster known as the Orphan Rocker, named after the nearby Orphan Rock. This is the first roller coaster to be completely
SUCNR1 (303 words) [view diff] exact match in snippet view article find links to article
Tian H, Ling L (May 2004). "Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors". Nature. 429 (6988): 188–93. doi:10.1038/nature02488
Jyn Erso (2,264 words) [view diff] no match in snippet view article find links to article
Jyn Erso is a fictional character in the Star Wars franchise, portrayed by English actress Felicity Jones in the 2016 film Rogue One. Jyn aids the Rebel
4-Aminopyridine (1,855 words) [view diff] no match in snippet view article find links to article
4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric
David Copperfield (character) (1,072 words) [view diff] exact match in snippet view article
for the funeral. Mr Murdstone and Jane, unwilling to care for the hated orphan, decide to send David to work in the family bottling factory. Life at the
Vancouver Orphan Kitten Rescue Association (2,704 words) [view diff] exact match in snippet view article find links to article
The Vancouver Orphan Kitten Rescue Association (VOKRA) is a no kill, non-profit cat rescue organization in Vancouver, British Columbia, Canada, providing
Gusperimus (757 words) [view diff] exact match in snippet view article find links to article
Bristol-Myers Squibb. Currently, it is manufactured and sponsored for use as an orphan drug and for clinical studies by the Japanese company Euro Nippon Kayaku
Bristol Myers Squibb (5,546 words) [view diff] no match in snippet view article find links to article
Bristol Myers Squibb (BMS) is an American multinational pharmaceutical company, headquartered in New York City. BMS is one of the world's largest pharmaceutical
Sodium phenylbutyrate (1,648 words) [view diff] exact match in snippet view article find links to article
excretion of excess nitrogen. It is an orphan drug, marketed by Ucyclyd Pharma under the trade name Buphenyl, by Swedish Orphan International (Sweden) as Ammonaps
Carl Johnson (Grand Theft Auto) (2,600 words) [view diff] no match in snippet view article
Carl "CJ" Johnson is a fictional character and the playable protagonist of the 2004 video game Grand Theft Auto: San Andreas, the fifth main installment
Imatinib (5,839 words) [view diff] no match in snippet view article find links to article
Imatinib, sold under the brand name Gleevec & Glivec (both marketed worldwide by Novartis) among others, is an oral chemotherapy medication used to treat
Isatuximab (3,034 words) [view diff] exact match in snippet view article find links to article
have demonstrated disease progression on the last therapy. It was granted orphan drug designation for multiple myeloma by the European Medicines Agency (EMA)
GPR32 (930 words) [view diff] exact match in snippet view article find links to article
initially identified and defined by molecular cloning in 1998 as coding for an orphan receptor, i.e. a protein with an amino acid sequence similar to known receptors
Hepatocyte nuclear factor 4 alpha (2,122 words) [view diff] exact match in snippet view article find links to article
F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB (Feb 2003). "The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction
Ursodeoxycholic acid (2,075 words) [view diff] exact match in snippet view article find links to article
approved for use in the United States in December 1987, and was designated an orphan drug. "Ursodiol Use During Pregnancy". Drugs.com. 4 November 2019. Retrieved
Sasuke Uchiha (8,965 words) [view diff] no match in snippet view article find links to article
Sasuke Uchiha (Japanese: うちは サスケ, Hepburn: Uchiha Sasuke) (/ˈsɑːskeɪ/) is a fictional character in the Naruto manga and anime franchise created by Masashi
Caffeine citrate (680 words) [view diff] no match in snippet view article find links to article
Caffeine citrate, sold under the brand name Cafcit among others, is a medication used to treat a lack of breathing in premature babies. Specifically it
Little Orphan Annie (1932 film) (220 words) [view diff] exact match in snippet view article
Little Orphan Annie is a 1932 American pre-Code comedy film directed by John S. Robertson, and written by Wanda Tuchock and Tom McNamara. It is based on
Clarice Starling (2,097 words) [view diff] no match in snippet view article find links to article
Clarice M. Starling is a fictional character and protagonist of the novels The Silence of the Lambs (1988) and Hannibal (1999) by Thomas Harris. In the
Alsatian Orphan (229 words) [view diff] exact match in snippet view article find links to article
The Alsatian Orphan / L'Orpheline Alsacienne is a sculpture made by the French artist Auguste Rodin (1840-1917). In the beginning of his career, Rodin
Natty Bumppo (1,356 words) [view diff] no match in snippet view article find links to article
Nathaniel "Natty" Bumppo is a fictional character and the protagonist of James Fenimore Cooper's pentalogy of novels known as the Leatherstocking Tales
Pomalidomide (967 words) [view diff] no match in snippet view article find links to article
Pomalidomide (INN; marketed as Pomalyst in the US and Imnovid in the European Union and Russia) is a derivative of thalidomide marketed by Celgene. It
Like Mike (1,211 words) [view diff] exact match in snippet view article find links to article
Lipnicki, Robert Forster, Crispin Glover and Eugene Levy, the film follows an orphan who gets basketball talents after finding a pair of Michael Jordan's shoes
James Frain (671 words) [view diff] exact match in snippet view article find links to article
The Tunnel (2013), Ferdinand Chevalier in the BBC/Space sci-fi thriller Orphan Black (2015–2017), Theo Galavan/Azrael in Fox's Gotham (2015–2016), and
Tiratricol (388 words) [view diff] exact match in snippet view article find links to article
resistance and adjuvant therapy of thyroid cancer. It is available as an orphan drug to be prescribed by registered specialists in Europe. Carvalho GA,
Faris Scherwiz (1,488 words) [view diff] no match in snippet view article find links to article
Faris Scherwiz is a fictional character in the Final Fantasy series. She first appears in Final Fantasy V as an early antagonist and later one of its protagonists
Al-Ma'un (1,538 words) [view diff] exact match in snippet view article find links to article
denieth the future judgment as a falsehood? ۝ It is he who pusheth away the orphan; ۝ and stirreth not up others to feed the poor. ۝ Woe be unto those who
Tarextumab (79 words) [view diff] exact match in snippet view article find links to article
as a possible treatment for cancer. In January 2015, the US FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and
Sasuke Uchiha (8,965 words) [view diff] no match in snippet view article find links to article
Sasuke Uchiha (Japanese: うちは サスケ, Hepburn: Uchiha Sasuke) (/ˈsɑːskeɪ/) is a fictional character in the Naruto manga and anime franchise created by Masashi
Like Mike (1,211 words) [view diff] exact match in snippet view article find links to article
Lipnicki, Robert Forster, Crispin Glover and Eugene Levy, the film follows an orphan who gets basketball talents after finding a pair of Michael Jordan's shoes
Zenarestat (96 words) [view diff] no match in snippet view article find links to article
Zenarestat (FK-366; FR-74366) is an aldose reductase inhibitor. It was investigated as a treatment of diabetic neuropathy and cataract, but its development
Isatuximab (3,034 words) [view diff] exact match in snippet view article find links to article
have demonstrated disease progression on the last therapy. It was granted orphan drug designation for multiple myeloma by the European Medicines Agency (EMA)
Bagheera (2,130 words) [view diff] no match in snippet view article find links to article
Bagheera is a fictional character in Rudyard Kipling's Mowgli stories in The Jungle Book (coll. 1894) and The Second Jungle Book (coll. 1895). He is a
Satralizumab (1,372 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for satralizumab fast track and orphan drug designations. The FDA granted the approval of Enspryng to Genentech
James Frain (671 words) [view diff] exact match in snippet view article find links to article
The Tunnel (2013), Ferdinand Chevalier in the BBC/Space sci-fi thriller Orphan Black (2015–2017), Theo Galavan/Azrael in Fox's Gotham (2015–2016), and
Nimotuzumab (803 words) [view diff] exact match in snippet view article find links to article
Immunology, Havana, Cuba) is a humanized monoclonal antibody that as of 2014 had orphan status in the US and EU for glioma, and marketing approval in India, China
Spinocerebellar ataxia (2,773 words) [view diff] exact match in snippet view article find links to article
Retrieved 2019-08-01. "Search Orphan Drug Designations and Approvals". www.accessdata.fda.gov. Retrieved 2019-08-01. "Search Orphan Drug Designations and Approvals"
Ciclosporin (4,738 words) [view diff] no match in snippet view article find links to article
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It
Alsatian Orphan (229 words) [view diff] exact match in snippet view article find links to article
The Alsatian Orphan / L'Orpheline Alsacienne is a sculpture made by the French artist Auguste Rodin (1840-1917). In the beginning of his career, Rodin
Garden of Eden (cellular automaton) (3,470 words) [view diff] exact match in snippet view article
a Garden of Eden if and only if it contains an orphan. For one-dimensional cellular automata, orphans and Gardens of Eden can be found by an efficient
Babacar (band) (259 words) [view diff] exact match in snippet view article
rock supergroup formed in England, featuring former members of Shelleyan Orphan, The Cure, and Presence. The group released one album in their brief existence
Sailor Jupiter (3,409 words) [view diff] no match in snippet view article find links to article
Makoto Kino (木野 まこと, Kino Makoto, renamed "Lita Kino" in some English adaptations), better known as Sailor Jupiter (セーラージュピター, Sērā Jupitā), is a fictional
Clubber Lang (802 words) [view diff] no match in snippet view article find links to article
James "Clubber" Lang is a fictional character created by Sylvester Stallone for the film Rocky III, which was released in 1982. Lang serves as the main
GPR83 (325 words) [view diff] exact match in snippet view article find links to article
"Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83)". Cytogenet Cell Genet. 90 (1–2):
Methoxsalen (696 words) [view diff] no match in snippet view article find links to article
Methoxsalen, sold under the brand name Oxsoralen among others, is a medication used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas
Captain Phasma (3,310 words) [view diff] no match in snippet view article find links to article
Captain Phasma is a fictional character in the Star Wars franchise, portrayed by English actress Gwendoline Christie. Introduced in Star Wars: The Force
Alison Steadman (1,310 words) [view diff] exact match in snippet view article find links to article
include Pride and Prejudice (1995), Gavin & Stacey (2007–2010, 2019) and Orphan Black (2015–2016). Her other film appearances include A Private Function
COUP-TFI (1,476 words) [view diff] exact match in snippet view article find links to article
mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22
Oxytocin (10,588 words) [view diff] no match in snippet view article find links to article
Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. It plays a role
Gilteritinib (504 words) [view diff] exact match in snippet view article find links to article
mutation as detected by an FDA-approved test. Gilteritinib was granted orphan drug status by the U.S. FDA, the European Commission (EC) and the Japan
Ravulizumab (649 words) [view diff] no match in snippet view article find links to article
Ravulizumab, sold under the brand name Ultomiris, is a humanized monoclonal antibody complement inhibitor medication designed for the treatment of paroxysmal
Urotensin-II receptor (2,078 words) [view diff] exact match in snippet view article find links to article
(1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14". Nature. 401 (6750): 282–6. doi:10.1038/45809. PMID 10499587
GPR63 (384 words) [view diff] exact match in snippet view article find links to article
1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056
Atezolizumab (3,956 words) [view diff] no match in snippet view article find links to article
Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC)
Snow White (Disney character) (4,186 words) [view diff] no match in snippet view article
Snow White is a fictional character and a main character from Walt Disney Productions' first animated feature film Snow White and the Seven Dwarfs (1937)
Defibrotide (1,247 words) [view diff] exact match in snippet view article find links to article
FDA granted the application for defibrotide priority review status and orphan drug designation. The FDA granted approval of Defitelio to Jazz Pharmaceuticals
Cascadia subduction zone (3,939 words) [view diff] exact match in snippet view article find links to article
Since no earthquake had been observed to produce it, scholars dubbed it an "orphan tsunami." Translating the Japanese calendar, Satake found the incident had
Sarepta Therapeutics (1,074 words) [view diff] no match in snippet view article find links to article
Sarepta Therapeutics, Inc. (Nasdaq: SRPT) is a medical research and drug development company with corporate offices and research facilities in Cambridge
Orphan Black (comic book) (3,064 words) [view diff] exact match in snippet view article
Orphan Black is a limited series of comic books based on the television series Orphan Black, which airs on BBC America in the United States and Space
Buprenorphine/naloxone (3,379 words) [view diff] no match in snippet view article find links to article
Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone
GPR17 (1,797 words) [view diff] exact match in snippet view article find links to article
functions of this receptor are disputed. Initially discovered in 1998 as an Orphan receptor, i.e. a receptor whose activating ligand(s) and function were unknown
Acanthamoeba keratitis (2,776 words) [view diff] exact match in snippet view article find links to article
important to vision. Recently, AK has been recognized as an orphan disease and a funded project, orphan diseases Acanthamoeba keratitis (ODAK), has tested the
Anaphylatoxin receptors (74 words) [view diff] exact match in snippet view article find links to article
16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1 Orphan GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42
Oliver Twist (character) (1,378 words) [view diff] exact match in snippet view article
the first child protagonist in an English novel. Based in the 1820s, the orphan, young Oliver is born in a parish workhouse in an unnamed town. His unmarried
Sotorasib (981 words) [view diff] exact match in snippet view article find links to article
Food and Drug Administration (FDA) granted the application for sotorasib orphan drug, fast track, priority review, and breakthrough therapy designations
Christine Daaé (1,783 words) [view diff] no match in snippet view article find links to article
Christine Daaé is a fictional character and the female protagonist of Gaston Leroux's 1910 novel The Phantom of the Opera and of the various adaptations
Glasdegib (689 words) [view diff] exact match in snippet view article find links to article
granted priority review and orphan drug designation by the U.S. Food and Drug Administration (FDA). It was granted orphan drug designation by the European
Yun and Yang (1,473 words) [view diff] no match in snippet view article find links to article
Yun (ユン) and Yang (ヤン, Yan) are a pair of fictional characters appearing in the Street Fighter fighting game series. The characters are twin brothers known
Fidarestat (154 words) [view diff] no match in snippet view article find links to article
Fidarestat (SNK-860) is an aldose reductase inhibitor under investigation for treatment of diabetic neuropathy. Aldose reductase inhibitor for treatment
Dark Castle Entertainment (482 words) [view diff] exact match in snippet view article find links to article
Reaping (2007) The Reaping DVD (2007) RocknRolla (2008) RocknRolla DVD (2008) Orphan (2009) Whiteout (2009) Whiteout DVD (2009) Ninja Assassin(2009) Ninja Assassin
Comic strip (6,362 words) [view diff] exact match in snippet view article find links to article
Alley Oop (1932–present) Bringing Up Father (1913–2000; 87 years) Little Orphan Annie (1924–2010; 86 years) Most newspaper comic strips are syndicated;
BD Wong (1,624 words) [view diff] exact match in snippet view article find links to article
starred in the U.S. premiere of James Fenton's acclaimed adaptation of The Orphan of Zhao, a classic Chinese legend that has its roots in the fourth century
Atezolizumab (3,956 words) [view diff] no match in snippet view article find links to article
Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC)
TLR10 (769 words) [view diff] exact match in snippet view article find links to article
This makes TLR10 unique among the TLR family. TLR10 was thought to be an "orphan" receptor, however, recent studies have identified ligands for TLR10 and
The Royal Alexandra and Albert School (685 words) [view diff] exact match in snippet view article find links to article
Royal Alexandra School, which was founded in 1758, and The Royal Albert orphan School, which was founded in 1864 as a national memorial to Prince Albert
TinEye (1,144 words) [view diff] exact match in snippet view article find links to article
looking to make use of imagery under orphan works to find the copyright holders of that imagery. Being that orphan works can be defined as "copyrighted
Dark Castle Entertainment (482 words) [view diff] exact match in snippet view article find links to article
Reaping (2007) The Reaping DVD (2007) RocknRolla (2008) RocknRolla DVD (2008) Orphan (2009) Whiteout (2009) Whiteout DVD (2009) Ninja Assassin(2009) Ninja Assassin
GPR116 (446 words) [view diff] exact match in snippet view article find links to article
(May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10
Molly Ringwald (2,715 words) [view diff] exact match in snippet view article find links to article
The Facts of Life (1979–80) after a casting director saw her playing an orphan in a stage production of the musical Annie. She and several other members
GPR45 (372 words) [view diff] exact match in snippet view article find links to article
DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
Zanubrutinib (1,214 words) [view diff] exact match in snippet view article find links to article
priority review, accelerated approval, breakthrough therapy designation, and orphan drug designation. The FDA approved zanubrutinib in November 2019, and granted
Lumiliximab (281 words) [view diff] exact match in snippet view article find links to article
antibody that targets CD23. It acts as an immunomodulator and was awarded orphan drug status and fast track designation by the FDA. It was investigated in
GPR39 (579 words) [view diff] exact match in snippet view article find links to article
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39". Biochem. Biophys. Res. Commun. 351 (1):
Little Annie Rooney (1,038 words) [view diff] exact match in snippet view article find links to article
Little Annie Rooney is a comic strip about a young orphaned girl who traveled about with her dog, Zero. King Features Syndicate launched the strip on January
Gendry (2,311 words) [view diff] exact match in snippet view article find links to article
proudly made for himself, which earned him the nickname "Bull" by fellow orphan boy Lommy Greenhands. Gendry is not a point of view character in the novels
Renly Baratheon (1,100 words) [view diff] no match in snippet view article find links to article
Renly Baratheon is a fictional character in the A Song of Ice and Fire series of fantasy novels by American author George R. R. Martin, and its television
Tomorrow (Annie) (1,169 words) [view diff] exact match in snippet view article
Charnin and Thomas Meehan began working on a musical based on the Little Orphan Annie comic strips, Annie. Strouse contributed a reworked version of "Replay"
Laawaris (1981 film) (775 words) [view diff] exact match in snippet view article
Laawaris (transl. Orphan or Scoundrel ) is an 1981 Indian drama film directed by Prakash Mehra. The film became known for its song "Mere Angene Mein Tumhara
Adhesion G protein-coupled receptor (3,397 words) [view diff] exact match in snippet view article find links to article
adhesion GPCRs. A majority of the adhesion GPCRs are orphan receptors and work is underway to de-orphanize many of these receptors . Adhesion GPCRs get their
GPR156 (368 words) [view diff] exact match in snippet view article find links to article
Watkins, Lyndsay R.; Orlandi, Cesare (2021-03-30). "In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity". British Journal
List of My-HiME characters (8,325 words) [view diff] exact match in snippet view article find links to article
attack by an Orphan. Mai materializes her Elements for the first time and also acquires her Child, Kagutsuchi, which she uses to defeat the Orphan. In the
Prokineticin receptor 1 (518 words) [view diff] exact match in snippet view article find links to article
and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402
Melphalan flufenamide (2,327 words) [view diff] exact match in snippet view article find links to article
The application for melphalan flufenamide was granted priority review and orphan drug designations. Melphalan flufenamide is the international nonproprietary
Snak (796 words) [view diff] no match in snippet view article find links to article
Snak (Danish for "chat") was a shareware Internet Relay Chat (IRC) client written by Kent Sorensen for the Macintosh platform. Snak was distributed as
PSB-SB-487 (175 words) [view diff] exact match in snippet view article find links to article
PSB-SB-487 is a coumarin derivative which is an antagonist at the former orphan receptor GPR55. Unlike older GPR55 antagonists such as O-1918, PSB-SB-487
Neuropeptide FF receptor 2 (543 words) [view diff] exact match in snippet view article find links to article
(2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc
Blue Sky Black Death (2,095 words) [view diff] exact match in snippet view article find links to article
started producing exclusively around 2000. Kingston, working under the name Orphan, began his solo producing career collaborating with rapper Noah23 and the
ROR1 (1,094 words) [view diff] exact match in snippet view article find links to article
by the ROR1 gene. ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family. The protein encoded by this gene is a receptor tyrosine
BD Wong (1,624 words) [view diff] exact match in snippet view article find links to article
starred in the U.S. premiere of James Fenton's acclaimed adaptation of The Orphan of Zhao, a classic Chinese legend that has its roots in the fourth century
James and the Giant Peach (1,714 words) [view diff] exact match in snippet view article find links to article
name in 1996, and a musical in 2010. The plot centres on a young English orphan boy who enters a gigantic, magical peach, and has a wild and surreal cross-world
Final Fantasy XIII (10,729 words) [view diff] exact match in snippet view article find links to article
beast Ragnarok and slay the sleeping fal'Cie Orphan, who keeps Cocoon afloat above Pulse. Slaying Orphan will result in the destruction of Cocoon. The
John Watts (New York politician) (1,219 words) [view diff] exact match in snippet view article
New York from 1802 to 1807. In 1831, Watts organized the Leake and Watts Orphan Asylum after his friend (who was also his sister Margaret's brother-in-law)
Selphie Tilmitt (2,359 words) [view diff] no match in snippet view article find links to article
Selphie Tilmitt (セルフィ・ティルミット, Serufi Tirumitto) is a fictional character from the 1999 role-playing video game Final Fantasy VIII. She is introduced as
Adèle Exarchopoulos (969 words) [view diff] exact match in snippet view article find links to article
and the Jailbird, a film by Belgian film director Michaël R. Roskam, and Orphan, a French film by Arnaud des Pallières in 2017. Exarchopoulos and actor
GPR34 (648 words) [view diff] exact match in snippet view article find links to article
Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno
Johnson & Johnson (11,759 words) [view diff] no match in snippet view article find links to article
Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged
Genzyme (1,955 words) [view diff] exact match in snippet view article find links to article
world’s population. Drugs used to treat such conditions are considered to be orphan drugs. Ceredase was the first effective treatment for Gaucher's disease
ACKR3 (1,091 words) [view diff] exact match in snippet view article find links to article
receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the
Goku (10,239 words) [view diff] no match in snippet view article find links to article
Son Goku is a fictional character and main protagonist of the Dragon Ball manga series created by Akira Toriyama. He is based on Sun Wukong (known as Son
Beechholme (269 words) [view diff] no match in snippet view article find links to article
Beechholme was a children's home in Fir Tree Road, Banstead, Surrey. It was founded in 1879 as a Residential School for poor children from the slums of
Second Doctor (2,586 words) [view diff] exact match in snippet view article find links to article
and Polly's departures, the Doctor and Jamie were joined by the Victorian orphan Victoria Waterfield (Deborah Watling) and 21st century astrophysicist Zoe
The Flash (season 5) (5,936 words) [view diff] case mismatch in snippet view article
Retrieved February 15, 2019. "TV REVIEW: THE FLASH S5 E16 - 'FAILURE IS AN ORPHAN'". Dynamic Forces. March 13, 2019. Retrieved April 19, 2019. "(#517) "Time
Peter Parker (Insomniac Games character) (4,012 words) [view diff] no match in snippet view article
Spider-Man is a superhero character created by Insomniac Games originally for the 2018 video game Marvel's Spider-Man. Based on the original character
Fedratinib (664 words) [view diff] exact match in snippet view article find links to article
Administration (FDA) granted the application for fedratinib priority review and orphan drug designations. The FDA granted the approval of Inrebic to Impact Biomedicines
Raistlin Majere (7,241 words) [view diff] no match in snippet view article find links to article
Raistlin Majere is a fictional character from the Dragonlance series of books created by Margaret Weis and Tracy Hickman. Raistlin played an extensive
Cobicistat (903 words) [view diff] no match in snippet view article find links to article
Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection (HIV/AIDS). Its major
Logan (film series character) (6,639 words) [view diff] no match in snippet view article
James "Logan" Howlett, better known by his codename, Wolverine, is a fictional character from 20th Century Fox's superhero film series X-Men, portrayed
Brenda Brave Helps Grandmother (287 words) [view diff] no match in snippet view article find links to article
Brenda Brave Helps Grandmother (original title: Kajsa Kavat) is a story by Astrid Lindgren about a young girl named Brenda (Kajsa) in Sweden. The book
Bruce Wayne (DC Extended Universe) (5,091 words) [view diff] no match in snippet view article
Bruce Wayne, also known by his vigilante alias Batman, is a fictional character in the DC Extended Universe based on the character of the same name. The
Magneto (film series character) (4,595 words) [view diff] no match in snippet view article
Erik Lehnsherr, also known as Magneto, is a fictional character in the X-Men film series, starting with X-Men (2000) and appearing in eight films ending