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searching for Opioid antagonist 56 found (111 total)

5'-Guanidinonaltrindole (401 words) [view diff] exact match in snippet view article find links to article

5'-Guanidinonaltrindole (5'-GNTI) is an opioid antagonist used in scientific research which is highly selective for the κ opioid receptor. It is 5x more

Morphinan (605 words) [view diff] exact match in snippet view article find links to article

including hydrocodone, hydromorphone, oxycodone and oxymorphone, and the opioid antagonist naloxone. The physiological behavior of morphinans (naturally occurring

U-50488 (322 words) [view diff] exact match in snippet view article find links to article

which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses

Norbinaltorphimine (321 words) [view diff] exact match in snippet view article find links to article

Norbinaltorphimine (nor-BNI or nBNI) is an opioid antagonist used in scientific research. It is one of the few opioid antagonists available that is highly

Deltorphin (413 words) [view diff] exact match in snippet view article find links to article

deltorphin uptake by brain microvessels, but neither the selective δ-opioid antagonist naltrindole nor a number of opioid peptides with different affinities

Hypoventilation (599 words) [view diff] exact match in snippet view article find links to article

the respiratory depression occurs from opioid overdose, usually an opioid antagonist, most likely naloxone, will be administered. This will rapidly reverse

Axelopran (761 words) [view diff] exact match in snippet view article find links to article

axelopran in three different pre-clinical models of cancer shows that a μ-opioid antagonist isolates distinct effects of the endogenous opioid system on tumor

Low-dose naltrexone (1,124 words) [view diff] exact match in snippet view article find links to article

prescribed for opioid dependence or alcohol dependence, as it is a strong opioid antagonist. It has been hypothesized that low-dose naltrexone might operate as

14-Phenylpropoxymetopon (309 words) [view diff] exact match in snippet view article find links to article

substitutions such as N-cyclopropyl or N-allyl, which normally result in μ-opioid antagonist compounds. It has never been used in humans, but would be expected

Sheila Bird (1,626 words) [view diff] exact match in snippet view article find links to article

proposed a prison-based randomized controlled trial of naloxone, the opioid antagonist, for prisoners-on-release who had a history of heroin injection. Bird

Take-home naloxone program (2,103 words) [view diff] exact match in snippet view article find links to article

a medication that was created to reverse opioid overdoses. As an opioid antagonist, it binds to the μ-opioid receptors blocking the opioid's effects

6β-Naltrexol-d4 (103 words) [view diff] exact match in snippet view article find links to article

2009). "The relative potency of inverse opioid agonists and a neutral opioid antagonist in precipitated withdrawal and antagonism of analgesia and toxicity"

PF-4455242 (272 words) [view diff] exact match in snippet view article find links to article

(August 2011). "Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine

Oxymorphazone (420 words) [view diff] exact match in snippet view article find links to article

irreversible μ-opioid full agonist Naloxazone, an irreversible μ-opioid antagonist Galetta S, Ling GS, Wolfin L, Pasternak GW (1982). "Receptor binding

C22H29NO3 (61 words) [view diff] exact match in snippet view article find links to article

The molecular formula C22H29NO3 may refer to: Cyprodime, an opioid antagonist from the morphinan family Norethisterone acetate oxime, a steroidal progestin

Propiram (629 words) [view diff] exact match in snippet view article find links to article

clinical trials in the United States and Canada. Propiram exhibits weak opioid antagonist activity on the μ receptor—quite a bit weaker than its agonist effects—and

Fencamfamin (1,146 words) [view diff] exact match in snippet view article find links to article

blocked by the selective dopamine D1 antagonist SCH 23390 and by the opioid antagonist naloxone. A similar place preference, which was blocked by naloxone

Laughter in animals (1,242 words) [view diff] exact match in snippet view article find links to article

avoid playback of 22-kHz calls. When rats are given naloxone (an opioid antagonist), tickling no longer evokes the 50-kHz vocalisation[citation needed]

Nektar Therapeutics (549 words) [view diff] exact match in snippet view article find links to article

candidate base consists of naloxegol (Movantik), a Phase III oral opioid antagonist, etirinotecan pegol, a topoisomerase inhibitor under Phase III clinical

Opioid epidemic (7,300 words) [view diff] exact match in snippet view article find links to article

provided over 250 ambulance services for overdoses, administering the opioid antagonist nasal spray Narcan (naloxone) in record numbers. North America's first

Tanning dependence (1,970 words) [view diff] exact match in snippet view article find links to article

blood system, a pathway to the brain. A small study also found the opioid antagonist naltrexone reduced preference for UV tanning beds and at higher doses

Jon Levine (neuroscientist) (436 words) [view diff] exact match in snippet view article

influential study showing that placebo analgesia could be blocked by the opioid antagonist naloxone. According to Fabrizio Benedetti (one of Levine's students)

John David Sinclair (894 words) [view diff] exact match in snippet view article find links to article

morphine, heroin, and endorphin produce their effects. Taking an opioid antagonist such as naltrexone or nalmefene reduces the reinforcement such that

State government response to the opioid epidemic in the United States (6,817 words) [view diff] exact match in snippet view article find links to article

(pop.40,000) ordered his officers to cease the administration of the opioid antagonist nasal spray naloxone during the Coronavirus pandemic, fearing that

Aticaprant (2,211 words) [view diff] case mismatch in snippet view article find links to article

Witcher J, et al. (February 2016). "Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel

Cleveland EMS (2,681 words) [view diff] exact match in snippet view article find links to article

Emergency Medical Services began carrying nasal-spray Narcan, the opioid antagonist drug that reverses an opioid overdose in 1985. In 2016, the division's

Cyprenorphine (902 words) [view diff] exact match in snippet view article find links to article

Smith CF (January 1987). "16-Me cyprenorphine (RX 8008M): a potent opioid antagonist with some delta selectivity". Life Sciences. 40 (3): 267–274. doi:10

Dezocine (1,803 words) [view diff] exact match in snippet view article find links to article

PMID 7363647. Strain EC, Preston KL, Liebson IA, Bigelow GE (August 1996). "Opioid antagonist effects of dezocine in opioid-dependent humans". Clinical Pharmacology

Ann E. Kelley (1,269 words) [view diff] exact match in snippet view article find links to article

consumption of salty and sweet foods was influenced injection of a μ-opioid antagonist into the nucleus accumbens in a similar way the intake of alcohol

Frisson (2,628 words) [view diff] exact match in snippet view article find links to article

consistently strong correlation with frisson, as one study showed that an opioid antagonist could block frisson from music. Leonard Meyer, a prominent philosopher

Antipruritic (3,582 words) [view diff] exact match in snippet view article find links to article

safety and kinetics after single and multiple oral doses of a new opioid antagonist". Journal of Clinical Pharmacology. 27 (3): 233–9. doi:10.1002/j.1552-4604

Howard Fields (neuroscientist) (1,309 words) [view diff] exact match in snippet view article

by endogenous opioids by demonstrating that it is blocked by the opioid antagonist naloxone. Later work by Fields and his colleagues led to the discovery

Social connection (4,814 words) [view diff] exact match in snippet view article find links to article

social disconnection. In humans, blocking mu-opioid receptors with the opioid antagonist naltrexone has been found to reduce feelings of warmth and affection

Venlafaxine (6,501 words) [view diff] exact match in snippet view article find links to article

These benefits with respect to pain were reversed with naloxone, an opioid antagonist, thus supporting an opioid mechanism. Venlafaxine is well absorbed

Earthworm (7,480 words) [view diff] exact match in snippet view article find links to article

substances have been found in earthworms. Injections of naloxone (an opioid antagonist) inhibit the escape responses of earthworms. This indicates that opioid

Problem gambling (6,175 words) [view diff] exact match in snippet view article find links to article

sustained-release lithium has shown efficacy in a preliminary trial. The opioid antagonist drug nalmefene has also been trialled quite successfully for the treatment

Quincy, Massachusetts (8,640 words) [view diff] exact match in snippet view article find links to article

four to five days. By 2014, police officers had administered the opioid antagonist over 300 times. Other cities and police departments throughout the

Dynorphin (4,425 words) [view diff] exact match in snippet view article find links to article

measured by tail-flick latency. Analgesia was partially eliminated by opioid antagonist naloxone. Han and Xie found dynorphin to be 6-10 times more potent

Opioid overdose (4,919 words) [view diff] exact match in snippet view article find links to article

Wang DS, Sternbach G, Varon J (May 1998). "Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine". The Journal of Emergency

Tramadol (9,009 words) [view diff] exact match in snippet view article find links to article

administration, hydration, and treatment of seizures. Naloxone, an opioid antagonist, can partially reverse some effects of tramadol overdose, particularly

Cleveland Division of Police (6,060 words) [view diff] exact match in snippet view article find links to article

city's first responders to carry the naloxone nasal spray Narcan, the opioid antagonist that can reverse the effects of a drug overdose. 150 zone cars were

General anaesthesia (8,404 words) [view diff] exact match in snippet view article find links to article

postoperative ileus, even after non-abdominal surgery. Administration of a μ-opioid antagonist such as alvimopan immediately after surgery can help accelerate the

Non-lethal weapon (6,294 words) [view diff] exact match in snippet view article find links to article

anesthesia and respiratory depression could have been reversed by an opioid antagonist such as naloxone, which is stocked by hospitals and most ambulances

Κ-opioid receptor (7,675 words) [view diff] exact match in snippet view article find links to article

Liang MT, Fields HL (November 2005). "A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats". Psychopharmacology

Social grooming (7,753 words) [view diff] exact match in snippet view article find links to article

with 4- to 10-week-old infants were given low doses of naloxone, an opioid antagonist that blocks the opioid receptor and inhibits the effects of endogenous

Addiction (31,228 words) [view diff] exact match in snippet view article find links to article

Pharmacological treatments for alcohol addiction include drugs like naltrexone (opioid antagonist), disulfiram, acamprosate, and topiramate. Rather than substituting

Harm reduction (9,507 words) [view diff] exact match in snippet view article find links to article

Suboxone). Oral/sublingual formulations of buprenorphine incorporate the opioid antagonist naloxone to prevent people from crushing the tablets and injecting

Acupuncture (14,149 words) [view diff] exact match in snippet view article find links to article

it is possible to inhibit acupuncture's analgesic effects with the opioid antagonist naloxone. Mechanical deformation of the skin by acupuncture needles

Pain in invertebrates (9,954 words) [view diff] exact match in snippet view article find links to article

vertebrates, they should delay or reduce any protective response and the opioid antagonist should counteract this. It has been found that molluscs and insects

Cerebroprotectant (6,036 words) [view diff] exact match in snippet view article find links to article

(trafermin. Fiblast) 1998 Growth factor 29 35 22 19 0 66 Naloxone 1981 Opioid antagonist 29 7 8 7 0 67 Ebselen 2009 Free radical scavenger; synthetic organo-selenium

Post-traumatic stress disorder and substance use disorders (2,777 words) [view diff] exact match in snippet view article find links to article

treatment of the PTSD and AUD comorbidity, with varying success. The opioid antagonist naltrexone is generally effective when administered alone in reducing

Fetal alcohol spectrum disorder (15,577 words) [view diff] exact match in snippet view article find links to article

these medications for pregnant women. Naltrexone is a nonselective opioid antagonist that is used to treat AUD and opioid use disorder. The long-term effects

Collaborative practice agreement (3,115 words) [view diff] exact match in snippet view article find links to article

of the drug therapy, initiate emergency contraception, dispense an opioid antagonist, and administer drugs by mouth, topically, by nose, or by injection

Emergent BioSolutions (7,280 words) [view diff] exact match in snippet view article find links to article

suffering from opioid overdose. Narcan, related to morphine, is an opioid antagonist that was originally synthesized and patented by Mozes J. Lewenstein

Autism therapies (18,880 words) [view diff] exact match in snippet view article find links to article

effective than the tricyclic antidepressant clomipramine, and that the opioid antagonist naltrexone hydrochloride is not effective. In small studies, memantine

Molecular and epigenetic mechanisms of alcoholism (6,687 words) [view diff] exact match in snippet view article find links to article

nausea, and headaches. Naltrexone Naltrexone (trade name Revia) is an opioid antagonist that is thought to work by interfering with the dopaminergic mesolimbic