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searching for Nucleophilic addition 83 found (197 total)

alternate case: nucleophilic addition

Dakin oxidation (1,519 words) [view diff] exact match in snippet view article find links to article

after Henry Drysdale Dakin. The Dakin oxidation starts with (1) nucleophilic addition of a hydroperoxide ion to the carbonyl carbon, forming a (2) tetrahedral
Reformatsky reaction (1,269 words) [view diff] exact match in snippet view article find links to article
less reactive than lithium enolates or Grignard reagents and hence nucleophilic addition to the ester group does not occur. The reaction was discovered by
Polymerization (1,443 words) [view diff] exact match in snippet view article find links to article
formaldehyde is an exceptionally reactive electrophile it allows nucleophilic addition of hemiacetal intermediates, which are in general short-lived and
Thermosetting polymer (1,708 words) [view diff] exact match in snippet view article find links to article
anionic or cationic catalysts and heat, or copolymerised through nucleophilic addition reactions with multifunctional crosslinking agents which are also
Mannich base (223 words) [view diff] exact match in snippet view article find links to article
Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary
Organostannane addition (971 words) [view diff] exact match in snippet view article find links to article
Organostannane addition reactions comprise the nucleophilic addition of an allyl-, allenyl-, or propargylstannane to an aldehyde, imine, or, in rare cases
Carboxypeptidase (816 words) [view diff] exact match in snippet view article find links to article
base to allow for the attack at the amide carbonyl group during nucleophilic addition. It acts as an acid during elimination when the water proton is
Biginelli reaction (1,074 words) [view diff] exact match in snippet view article find links to article
aldehyde is the rate-limiting step leading to the carbenium ion 2. The nucleophilic addition of urea gives the intermediate 4, which quickly dehydrates to give
Wulff–Dötz reaction (1,502 words) [view diff] exact match in snippet view article find links to article
corresponding aryl product, or it could be further employed for a nucleophilic addition to aromatic system strategy for synthesis of fully-substituted benzene
Pyrrolidine (589 words) [view diff] exact match in snippet view article find links to article
compounds. It is used to activate ketones and aldehydes toward nucleophilic addition by formation of enamines (e.g. used in the Stork enamine alkylation):
Fukuyama coupling (901 words) [view diff] exact match in snippet view article find links to article
compared to oxidative addition of palladium to aryl bromides or the nucleophilic addition of zinc reagents to aldehydes. Although the Fukuyama cross-coupling
Bucherer–Bergs reaction (783 words) [view diff] exact match in snippet view article find links to article
formed imine is attacked by the isocyanide to form the aminonitrile. Nucleophilic addition of aminonitrile to CO2 leads to cyano-carbamic acid, which undergoes
Benzylic activation and stereocontrol in tricarbonyl(arene)chromium complexes (1,352 words) [view diff] exact match in snippet view article
facilitating dissociation of a benzylic proton, leaving group, or nucleophilic addition to the homobenzylic position of styrenes. Further transformations
Insulin-degrading enzyme (2,074 words) [view diff] exact match in snippet view article find links to article
re-establishment of the Zn2+−OH bond broken previously at the INT1 level. The nucleophilic addition and the protonation of peptide amide nitrogen is a very fast process
Peter Pauson (766 words) [view diff] exact match in snippet view article find links to article
of substituted cyclohexadienyl tricarbonylmanganese complexes by nucleophilic addition reactions of functionally substituted ($\eta$-arene) tricarbonylmanganese
Organocerium chemistry (835 words) [view diff] case mismatch in snippet view article find links to article
T.; Suguira, Y.; Takiyama, N. (1984), "Organocerium reagents. Nucleophilic Addition to Easily Enolizable Ketones", Tetrahedron Letters, 25 (38): 4233–4236
N-philes (88 words) [view diff] exact match in snippet view article find links to article
Schiesser, Carl H. (2002). "5-Azahexenoyl radicals cyclize via nucleophilic addition to the acyl carbon rather than 5-exo homolytic addition at the imine"
2,4-Dinitrophenylhydrazine (565 words) [view diff] exact match in snippet view article find links to article
Mechanistically, it is an example of addition-elimination reaction: nucleophilic addition of the -NH2 group to the C=O carbonyl group, followed by the elimination
3,9-Divinyl-2,4,8,10-tetraoxaspiro(5.5)undecane (1,011 words) [view diff] exact match in snippet view article
requires long reaction times at elevated temperatures, at which the nucleophilic addition of water and alcohol to the double bond of the unsaturated aldehyde
Phenylsodium (981 words) [view diff] exact match in snippet view article find links to article
C6H6 + NaCl + C6H5CH2Na The benzylsodium can then be used in a nucleophilic addition. The effectiveness of the metallation can be determined by carbonating
Hoesch reaction (310 words) [view diff] exact match in snippet view article find links to article
mechanism of the reaction involves two steps. The first step is a nucleophilic addition to the nitrile with the aid of a polarizing Lewis acid, forming
Aryne (2,936 words) [view diff] exact match in snippet view article find links to article
mechanism. The resulting benzyne forms addition products, usually by nucleophilic addition and protonation. Generation of the benzyne intermediate is the slow
Phenyllithium (656 words) [view diff] exact match in snippet view article find links to article
use of PhLi is to facilitate formation of carbon-carbon bonds by nucleophilic addition and substitution reactions: PhLi + R2C=O → PhR2COLi 2-Phenylpyridine
Organomanganese chemistry (977 words) [view diff] exact match in snippet view article find links to article
Leon A. P. Kane-Maguire, Ephraim D. Honig, Dwight A. Sweigart "Nucleophilic addition to coordinated cyclic π-hydrocarbons: mechanistic and synthetic
Pyruvate decarboxylase (1,153 words) [view diff] exact match in snippet view article find links to article
this regulatory site. The conformational change involves a 1,2 nucleophilic addition. This reaction, the formation of a thioketal, transforms the enzyme
Samarium(II) iodide (927 words) [view diff] exact match in snippet view article
olefinic ketones. Sequential radical cyclization/intermolecular nucleophilic addition and substitution reactions". J. Org. Chem. 57 (11): 3132–3139. doi:10
Stereoselectivity (1,006 words) [view diff] exact match in snippet view article find links to article
predicts the major diastereomer resulting from the diastereoselective nucleophilic addition to a carbonyl group next to a chiral center. The chiral center need
Heteroatom-promoted lateral lithiation (1,692 words) [view diff] exact match in snippet view article find links to article
substituted benzenes and heterocycles. Aldehyde substituents suffer nucleophilic addition in the presence of organolithium compounds; however, adducts of
Electrophile (2,316 words) [view diff] exact match in snippet view article find links to article
detail for alkynes, below), in which transfer of the proton and nucleophilic addition occur in a concerted manner. The extent to which each pathway contributes
Carbon–nitrogen bond (677 words) [view diff] exact match in snippet view article find links to article
Schiesser, Carl H. (2002). "5-Azahexenoyl radicals cyclize via nucleophilic addition to the acyl carbon rather than 5-exo homolytic addition at the imine"
Bergman cyclization (773 words) [view diff] case mismatch in snippet view article find links to article
Perrin, Charles L.; Rodgers, Betsy L.; O'Connor, Joseph M. (2007). "Nucleophilic Addition to a p-Benzyne Derived from an Enediyne: A New Mechanism for Halide
Vinylogy (906 words) [view diff] case mismatch in snippet view article find links to article
Marilda P.; Hoang, Tung T.; Dudley, Gregory B. (2011). "Tandem Nucleophilic Addition / Fragmentation of Vinylogous Acyl Triflates: 2-Methyl-2-(1-Oxo-5-Heptynyl)-1
Epoxide (2,304 words) [view diff] exact match in snippet view article find links to article
corresponding alcohol. This reduction process results from the nucleophilic addition of hydride (H−). Reductive cleavage of epoxides gives β-lithioalkoxides
Walsh diagram (1,726 words) [view diff] exact match in snippet view article find links to article
Orbital interaction diagram for nucleophilic addition to CH3+
Potassium tert-butoxide (692 words) [view diff] exact match in snippet view article find links to article
hydroxide. Its steric bulk inhibits the group from participating in nucleophilic addition, such as in a Williamson ether synthesis or related SN2 reactions
Petasis reaction (3,232 words) [view diff] case mismatch in snippet view article find links to article
maint: multiple names: authors list (link) Batey, R.A. (2005). "Nucleophilic Addition Reactions of Aryl and Alkenylboronic Acids and Their Derivatives
Acetoacetate decarboxylase (2,274 words) [view diff] exact match in snippet view article find links to article
protonated as an ammonium cation, making it unreactive for the nucleophilic addition necessary to form the Schiff base. Building upon this finding, Westheimer
Michael Mingos (538 words) [view diff] exact match in snippet view article find links to article
University of Sussex. OCLC 500519525. Davies, Stephen G. (1978). "Nucleophilic addition to organotransition metal cations containing unsaturated hydrocarbon
Stieglitz rearrangement (2,201 words) [view diff] exact match in snippet view article find links to article
missing and the stabilization of the intermediate proceeds via a nucleophilic addition of a water molecule, dissociation of a proton and tautomerism from
Enamine (1,800 words) [view diff] exact match in snippet view article find links to article
final dicarbonyl product. The enamine starting material undergoes a nucleophilic addition to acyl halides forming the iminium salt intermediate which can
Sandmeyer reaction (1,738 words) [view diff] exact match in snippet view article find links to article
the aryl cation instead of radical and is known to generate other nucleophilic addition side products in addition to the desired hydroxylation product.
Abramov reaction (1,098 words) [view diff] exact match in snippet view article find links to article
such as phosphites, phosphonites, and phosphinites may undergo nucleophilic addition to carbon atoms in simple carbonyl compounds. When fully esterified
Half sandwich compound (1,611 words) [view diff] exact match in snippet view article find links to article
exhibit enhanced reactivity toward nucleophiles. Subsequent to nucleophilic addition, the modified arene can be recovered from the metal. Half-sandwich
Bent metallocene (944 words) [view diff] case mismatch in snippet view article find links to article
1021/ar9900109. PMID 10673320. Stephen G. Davies; et al. (1977). "Nucleophilic Addition to Organotransition Metal Cations Containing Unsaturated Hydrocarbon
Hapten (2,512 words) [view diff] exact match in snippet view article find links to article
centre, nucleophilic substitution on an unsaturated centre and nucleophilic addition. Other reactions are also possible, such as electrophilic substitution
Myristoylation (2,277 words) [view diff] exact match in snippet view article find links to article
the protein. The addition of the myristoyl group proceeds via a nucleophilic addition-elimination reaction. First, myristoyl coenzyme A (CoA) is positioned
Base-promoted epoxide isomerization (1,120 words) [view diff] exact match in snippet view article find links to article
(4) Terminal epoxides suffer from the limitation that competitive nucleophilic addition of the base to the unsubstituted epoxide carbon may take place.
SEA Native Peptide Ligation (638 words) [view diff] exact match in snippet view article find links to article
systems because its reactivity is dictated by the intramolecular nucleophilic addition of one SEA thiol group on the C-terminal carbonyl group of the peptide
Nitroethylene (844 words) [view diff] exact match in snippet view article find links to article
sensitive to polymerization by traces of water. In addition to standard nucleophilic addition reactions on the C=C bond, nitroethylene can serve as a Michael
Sporolides (485 words) [view diff] case mismatch in snippet view article find links to article
Perrin, Charles L.; Rodgers, Betsy L.; O'Connor, Joseph M. (2007). "Nucleophilic Addition to a p-Benzyne Derived from an Enediyne: A New Mechanism for Halide
1,3-Dipolar cycloaddition (6,426 words) [view diff] exact match in snippet view article find links to article
scheme below). The polar reaction, N-cyclopentenyl pyrrolidine nucleophilic addition to the diazo compound, proceeds 1,500 times faster in polar DMSO
Metal–halogen exchange (1,200 words) [view diff] exact match in snippet view article find links to article
exchange is typically a fast reaction. It is usually faster than nucleophilic addition and can sometimes exceed the rate of proton transfer. Exchange rates
Jack D. Dunitz (1,903 words) [view diff] exact match in snippet view article find links to article
D.; Shefter, E. (1973). "Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group". Journal of the American Chemical Society.
Carbyl sulfate (493 words) [view diff] exact match in snippet view article find links to article
functional compounds with a variety of applications are available by nucleophilic addition at the activated double bond of the vinyl sulfonic acid and its
Metal carbon dioxide complex (2,223 words) [view diff] exact match in snippet view article find links to article
insertion to vinylarenes. In order to regenerate reactive Rh-H after nucleophilic addition to CO2, photocatalytic proton-coupled electron transfer approach
Vicinal difunctionalization (1,405 words) [view diff] exact match in snippet view article find links to article
electrophile is an alkyl halide. The mechanism proceeds in two stages: β-nucleophilic addition to the unsaturated carbonyl compound, followed by electrophilic
Ethyl acrylate (1,418 words) [view diff] exact match in snippet view article find links to article
a Michael addition to β-alanine derivatives in high yields: The nucleophilic addition at ethyl acrylate as an α,β-unsaturated carbonyl compound is a frequent
Electrophilic substitution of unsaturated silanes (1,477 words) [view diff] exact match in snippet view article find links to article
elimination to generate the double bond is stereospecifically anti, nucleophilic addition to either face of the silyl-stabilized carbanion leads to the formation
Function-spacer-lipid Kode construct (3,722 words) [view diff] exact match in snippet view article find links to article
effective synthetic approach is based on the well-known Michael nucleophilic addition to maleimides (Fig. 7). Synthetic "Gylcolipids" – one family of
Portentol (400 words) [view diff] exact match in snippet view article find links to article
bond formation between C7 and C2 would involve an intramolecular nucleophilic addition of an enolized β-keto-δ-lactone moiety onto 3. The total synthesis
Metallo-ene reaction (1,216 words) [view diff] exact match in snippet view article find links to article
aldehyde to which a propargyl alcohol appendage was attached via nucleophilic addition. Reduction followed by Appel reaction and Finkelstein reaction would
Hans-Beat Bürgi (604 words) [view diff] exact match in snippet view article find links to article
Shefter, Eli. (July 1973). "Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group". Journal of the American Chemical Society.
Malcolm Green (chemist) (1,192 words) [view diff] exact match in snippet view article
Stephen G.; Green, Malcolm L.H.; Mingos, D.Michael P. (1978). "Nucleophilic addition to organotransition metal cations containing unsaturated hydrocarbon
Trisilaallene (1,551 words) [view diff] exact match in snippet view article find links to article
atom and +1.016 / +1.026 on the terminal atoms. Therefore, the nucleophilic addition of alcohol occurs at the terminal atoms. This charge distribution
Negishi coupling (3,992 words) [view diff] exact match in snippet view article find links to article
dimethylacetamide (DMAC). The catalytic I2 serves to activate the zinc towards nucleophilic addition. Aryl zincs can be synthesized using mild reaction conditions via
Germanium (7,313 words) [view diff] exact match in snippet view article find links to article
Nucleophilic addition with an organogermanium compound
Diisobutyl phthalate (3,721 words) [view diff] exact match in snippet view article find links to article
"Plasticizers: Synthesis of phthalate esters via FeCl3-catalyzed nucleophilic addition of alcohols to phthalic anhydride". Results in Chemistry. 3: 100190
(+)-CPCA (4,044 words) [view diff] exact match in snippet view article
PMID 9934496. Hauck AE, Giam CS (1980). "Regioselective nucleophilic addition of organolithium compounds to 3-(4,4-dimethyloxazolin-2-yl)pyridine"
Quinone methide (1,865 words) [view diff] exact match in snippet view article find links to article
methides. Quinone methides are cross-conjugated rather than aromatic. Nucleophilic addition at the exo-cyclic double bond will result in rearomatisation, making
Hammett equation (4,025 words) [view diff] exact match in snippet view article find links to article
of the non-leaving group can in fact accelerate the rate of the nucleophilic addition reaction when X is an EWG. This is attributed to the resonance contribution
Phosphinidene (2,005 words) [view diff] exact match in snippet view article find links to article
phosphines, etc.) to form phosphinidene-nucleophile adducts Upon nucleophilic addition, the tri-coordinated phosphorus atom becomes non-planar, and it
Nucleotide pyrophosphatase/phosphodiesterase (1,857 words) [view diff] exact match in snippet view article find links to article
phosphodiester substrate. Red and blue curved arrows represent nucleophilic addition (AN) and elimination (DN) steps, respectively, of the phosphoryl
Roy A. Periana (1,541 words) [view diff] exact match in snippet view article find links to article
metallacyclobutanes, including one with a tertiary metal-carbon bond, by nucleophilic addition to .pi.-allyl complexes". J. Am. Chem. Soc. 108 (23): 7346–7355
Zinc (16,737 words) [view diff] exact match in snippet view article find links to article
expensive and difficult to handle. Organozincs typically perform nucleophilic addition on electrophiles such as aldehydes, which are then reduced to alcohols
Kalkitoxin (2,902 words) [view diff] exact match in snippet view article find links to article
4-phenyl-2-oxazolidinone carrying an (S)-N-trans-crotonyl group through a 1,4-nucleophilic addition to the α,β-unsaturation of the crotonyl group. This method is advantageous
Aza-Cope rearrangement (5,704 words) [view diff] exact match in snippet view article find links to article
in the generation iminium ions. They are typically installed by nucleophilic addition onto an iminium ion, generally produced by amine alkylation with
Chao-Jun Li (1,308 words) [view diff] exact match in snippet view article find links to article
breakthroughs in using hydrazones as organometallic surrogates in nucleophilic addition and cross-coupling, the direct amination of phenol derivatives.
Persistent carbene (6,933 words) [view diff] exact match in snippet view article find links to article
even moderate acidity. Although imidazolium salts are stable to nucleophilic addition, other non-aromatic salts are not (i.e. formamidinium salts). In
Glucosepane (3,323 words) [view diff] exact match in snippet view article find links to article
condenses with the arginine side chain to yield glucosepane in nucleophilic addition-elimination reactions of the nitrogens of arginine and the electrophilic
Germanium compounds (1,233 words) [view diff] exact match in snippet view article find links to article
Nucleophilic addition with an organogermanium compound.
Carbon-carbon bond activation (1,305 words) [view diff] exact match in snippet view article find links to article
metallacyclobutanes, including one with a tertiary metal-carbon bond, by nucleophilic addition to .pi.-allyl complexes". Journal of the American Chemical Society
4-Ipomeanol (3,270 words) [view diff] exact match in snippet view article find links to article
strong base to be eliminated. As a result of this, irreversible nucleophilic addition reactions are possible: a nucleophile can add to the carbonyl carbon
Single-walled carbon nanohorn (7,074 words) [view diff] exact match in snippet view article find links to article
direct attack of a free amino group on the nanohorn sidewalls (nucleophilic addition) and (2) amidation reaction of the carboxylic functions in oxidized