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Longer titles found: Neurodegeneration with brain iron accumulation (view), Pantothenate kinase-associated neurodegeneration (view), Molecular Neurodegeneration (view), Translational Neurodegeneration (view)

searching for Neurodegeneration 310 found (887 total)

alternate case: neurodegeneration

Nicotinamide adenine dinucleotide (8,518 words) [view diff] no match in snippet view article find links to article

Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists
MiR-218 microRNA precursor family (477 words) [view diff] exact match in snippet view article find links to article
miR-218 exhibit hyperexcitability, neuromuscular junction failure, and neurodegeneration, as demonstrated by knockout mouse models. The involvement of miR-218
Experimental Neurology (96 words) [view diff] exact match in snippet view article find links to article
562. In 1997, Experimental Neurology absorbed the quarterly journal Neurodegeneration, which had been established in 1992. "Experimental Neurology". 2018
Wolfson Centre for Age-Related Diseases (86 words) [view diff] exact match in snippet view article find links to article
the Receptors and Signalling Group, the Neurorestoration Group and Neurodegeneration and Clinical Trials Group. The centre is directed by Professor Pat
Occipital bun (446 words) [view diff] exact match in snippet view article find links to article
where neurogenesis and regeneration, where normal healing without neurodegeneration is factually called adult neurogeneration. Indicating a neurobiological
Pseudopupil (312 words) [view diff] exact match in snippet view article find links to article
observer is viewing. The pseudopupil analysis technique is used to study neurodegeneration in insects like Drosophila. It is especially useful for study of neurodegenerative
DNAJC3 (1,471 words) [view diff] exact match in snippet view article find links to article
to diabetes mellitus as well as multi system neurodegeneration. Diabetes mellitus and neurodegeneration are common diseases for which shared genetic factors
Beta-mannosidosis (672 words) [view diff] exact match in snippet view article find links to article
variable clinical presentation. Infantile onset forms show severe neurodegeneration, while some children have intellectual disability. Hearing loss and
MIND diet (1,223 words) [view diff] exact match in snippet view article find links to article
shown to improve cognition; however, neither were developed to slow neurodegeneration (e.g. Alzheimer's disease). Therefore, a team at Rush University Medical
Dystonin (1,453 words) [view diff] exact match in snippet view article find links to article
expression, mice defective for this gene show skin blistering and neurodegeneration. Dystonin has been shown to interact with collagen, type XVII, alpha
Pyrinuron (174 words) [view diff] exact match in snippet view article find links to article
insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide
Hsp70 (4,567 words) [view diff] exact match in snippet view article find links to article
Hsp70 overexpression suppressed poly-Q dependent aggregation and neurodegeneration in cell cultures, yeast, fly, and mouse models, and deletion of hsp70
Sanford Burnham Prebys Medical Discovery Institute (1,587 words) [view diff] exact match in snippet view article find links to article
and translational research, with major research programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The
Brain and Mind Centre (201 words) [view diff] exact match in snippet view article find links to article
mind. Child development and behaviour, mental health, and ageing and neurodegeneration are among the greatest health challenges of the 21st century. The
National Institute of Neurological Disorders and Stroke (3,012 words) [view diff] exact match in snippet view article find links to article
the fundamental biology of the brain and nervous system, genetics, neurodegeneration, learning and memory, motor control, brain repair, and synapses. NINDS
Glyceraldehyde 3-phosphate dehydrogenase (3,145 words) [view diff] no match in snippet view article find links to article
Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) (EC 1.2.1.12) is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and
Cypermethrin (1,165 words) [view diff] exact match in snippet view article find links to article
dopaminergic neurodegeneration in rats, and postnatal exposure enhances the susceptibility of animals to dopaminergic neurodegeneration if rechallenged
Hirano body (848 words) [view diff] exact match in snippet view article find links to article
bodies have been noted as a function of age without obvious underlying neurodegeneration. The Sommer’s sector (CA1) of the hippocampus has been described to
Mir-181 microRNA precursor (4,190 words) [view diff] exact match in snippet view article find links to article
Hillman D, Sugimori M, Llinas R, Greengard P (July 2007). "Cerebellar neurodegeneration in the absence of microRNAs". The Journal of Experimental Medicine
KCNA3 (4,344 words) [view diff] exact match in snippet view article find links to article
of disease-associated-microglia in Alzheimer's disease". Molecular Neurodegeneration. 13 (1): 24. doi:10.1186/s13024-018-0254-8. PMC 5963076. PMID 29784049
Long-term depression (5,321 words) [view diff] exact match in snippet view article find links to article
after synapses have stabilized, and is regulated by GSK3β. During neurodegeneration, there is the possibility that there is deregulation of GSK3β resulting
Neurogranin (660 words) [view diff] exact match in snippet view article find links to article
further discussed as marker for synaptic dysfunction in age-related neurodegeneration. It has also been shown to be specifically increased in patients with
ADPRHL2 (914 words) [view diff] exact match in snippet view article find links to article
a recently defined disorder called stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS; OMIM: 618170). The CONDSIAS
KAT5 (2,893 words) [view diff] exact match in snippet view article find links to article
cellular homeostasis and organismal health so as to counteract aging and neurodegeneration. HTATIP has been shown to interact with: Androgen receptor, BCL3,
Pennington Biomedical Research Center (784 words) [view diff] exact match in snippet view article find links to article
Signaling, Neurodegeneration: Aging and Neurodegeneration, Blood Brain Barrier I, Blood Brain Barrier II, Inflammation and Neurodegeneration, Nutritional
Katerina Akassoglou (1,877 words) [view diff] exact match in snippet view article find links to article
barrier integrity leads to fibrinogen leakage into the brain inducing neurodegeneration. Akassoglou is internationally recognized for her scientific discoveries
GRID2 (2,079 words) [view diff] exact match in snippet view article find links to article
Jager PL, Takahashi KA, Jiang W, Linden DJ, Heintz N (Aug 1997). "Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene"
Experimental autoimmune encephalomyelitis (2,035 words) [view diff] exact match in snippet view article find links to article
white matter of age-matched controls, and this may contribute to neurodegeneration in the disease pathological patterns: EAE is unable to reproduce MS
Mir-277 microRNA precursor family (246 words) [view diff] exact match in snippet view article find links to article
Chen D, Jin P (2012). Orr HT (ed.). "MicroRNA-277 modulates the neurodegeneration caused by Fragile X premutation rCGG repeats". PLOS Genetics. 8 (5):
Ted M. Dawson (2,741 words) [view diff] exact match in snippet view article find links to article
dystonia-parkinsons.org. "CurePSP, the Leading Organization for Prime of Life Neurodegeneration". CurePSP. "ASAP: Aligning Science Across Parkinson's". ASAP. "AGY
Phosphatidylinositol 3,5-bisphosphate (2,638 words) [view diff] exact match in snippet view article find links to article
decrease in PtdIns(3,5)P2 levels and cause similar massive central neurodegeneration and peripheral neuropathy. These studies suggest that reduced PtdIns(3
Neuromelanin (844 words) [view diff] exact match in snippet view article find links to article
Neuromelanin-containing neurons in the substantia nigra undergo neurodegeneration during Parkinson's disease. Motor symptoms of Parkinson's disease
Messenger RNP (853 words) [view diff] exact match in snippet view article find links to article
connected to RNA binding proteins show signs of causing neurodevelopment, neurodegeneration or neuropsychiatric disorders. An example of one of these diseases
Fig4 (2,781 words) [view diff] exact match in snippet view article find links to article
isolated fibroblasts, diluted pigmentation, central and peripheral neurodegeneration, hydrocephalus, abnormal tremor and gait, and eventually juvenile
Sirtuin 2 (3,647 words) [view diff] no match in snippet view article find links to article
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent
Jaime Imitola (1,194 words) [view diff] exact match in snippet view article find links to article
Progressive Multiple Sclerosis and the molecular and cellular mechanisms of neurodegeneration and repair in humans. His research includes the translational neuroscience
ZNF746 (134 words) [view diff] exact match in snippet view article find links to article
in humans, is encoded by the ZNF746 gene and is involved in the neurodegeneration of Parkinson's disease. GRCh38: Ensembl release 89: ENSG00000181220
CHI3L1 (2,262 words) [view diff] no match in snippet view article find links to article
Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by
Chorea acanthocytosis (733 words) [view diff] exact match in snippet view article find links to article
or even make a late appearance in the course of the disease.) and neurodegeneration causing a choreiform movement disorder. Another one of them would
Apitoxin (279 words) [view diff] exact match in snippet view article find links to article
Sabrina (2020-01-21). "Apitoxin and Its Components against Cancer, Neurodegeneration and Rheumatoid Arthritis: Limitations and Possibilities". Toxins.
Dizocilpine (3,404 words) [view diff] exact match in snippet view article find links to article
of excitotoxic neurodegeneration. The administration of dizocilpine protected the hippocampus from ischemia-induced neurodegeneration in the gerbil. The
Autophagy (9,391 words) [view diff] exact match in snippet view article find links to article
in autophagy have been linked to various human diseases, including neurodegeneration and cancer, and interest in modulating autophagy as a potential treatment
Centre for Research in Neurodegenerative Diseases (286 words) [view diff] exact match in snippet view article find links to article
Drs. Mark Tanz and Lionel Schipper. The Tanz Centre for Research in Neurodegeneration is currently located at the Toronto Western Hospital in the Krembil
Sphingolipid (2,590 words) [view diff] exact match in snippet view article find links to article
protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2) to trigger neurodegeneration of adult photoreceptors. Sphingosine Sphingosyl phosphatide Chun J
Excitotoxicity (2,787 words) [view diff] exact match in snippet view article find links to article
Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration". Mitochondrion. 10 (5): 573–8. doi:10.1016/j.mito.2010.04.007. PMC 2918703
Emad Alnemri (237 words) [view diff] exact match in snippet view article find links to article
discovered that a mutation in the mitochondrial serine protease Omi causes neurodegeneration. He studied at the University of Jordan on the "Isolation and characterization
3-Hydroxyisobutyryl-CoA deacylase deficiency (310 words) [view diff] exact match in snippet view article find links to article
that is associated with severely delayed psychomotor development, neurodegeneration, increased lactic acid and brain lesions in the basal ganglia. Fewer
KCNB1 (3,743 words) [view diff] exact match in snippet view article find links to article
probability of the channel remaining open can also potentially drive neurodegeneration. Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD)
MiR-338 (658 words) [view diff] exact match in snippet view article find links to article
SA (2008). Akbarian S (ed.). "A miRNA signature of prion induced neurodegeneration". PLOS ONE. 3 (11): e3652. Bibcode:2008PLoSO...3.3652S. doi:10.1371/journal
Ubiquitin carboxy-terminal hydrolase L1 (2,634 words) [view diff] exact match in snippet view article find links to article
diabetes and neurodegenerative diseases. Patients with early-onset neurodegeneration in which the causative mutation was in the UCHL1 gene (specifically
Debora Marks (911 words) [view diff] exact match in snippet view article find links to article
Early Career Award by the Chan Zuckerberg Initiative as part of the Neurodegeneration Challenge Network. "Debora S. Marks Lab". Retrieved July 11, 2016
Beta-propeller (1,988 words) [view diff] exact match in snippet view article find links to article
allowing for its unique function. Beta-propeller protein-associated neurodegeneration (BPAN) is a condition characterized by early onset seizures, developmental
Glial scar (2,927 words) [view diff] exact match in snippet view article find links to article
begin the healing process in the nervous system. In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial
Ying-Hui Fu (2,201 words) [view diff] no match in snippet view article find links to article
Ying-Hui Fu (Chinese: 傅嫈惠) is a Taiwanese-American biologist and human geneticist who has made important contributions to understanding the genetics of
Mir-153 microRNA precursor family (768 words) [view diff] exact match in snippet view article find links to article
of Amyloid precursor protein affect microRNA function". Molecular Neurodegeneration. 6: 70. doi:10.1186/1750-1326-6-70. PMC 3195754. PMID 21982160. Bao
Malú G. Tansey (2,788 words) [view diff] exact match in snippet view article find links to article
(6 March 2006). "The role of TNF in in vitro and in vivo models of neurodegeneration". The FASEB Journal. 20 (4): A505. doi:10.1096/fasebj.20.4.A505-b
Neurofilament light polypeptide (1,698 words) [view diff] exact match in snippet view article find links to article
1016/j.mcn.2018.12.003. PMID 30529227. S2CID 54437514. The very rapid neurodegeneration of prion disease results in strong signals from surrogate protein
Substantia nigra (5,007 words) [view diff] exact match in snippet view article find links to article
calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration". Neurodegeneration. 5 (4): 313–8. doi:10.1006/neur.1996.0042. PMID 9117542
Frances Platt (660 words) [view diff] exact match in snippet view article find links to article
as lysosomal storage diseases, progressive conditions that lead to neurodegeneration. She was elected Fellow of the Royal Society in 2021. Platt was interested
Changjoon Justin Lee (3,155 words) [view diff] exact match in snippet view article find links to article
severe reactive astrocytes as a key factor in Alzheimer's disease neurodegeneration. Lee has been involved in the development of several research-related
Frances Platt (660 words) [view diff] exact match in snippet view article find links to article
as lysosomal storage diseases, progressive conditions that lead to neurodegeneration. She was elected Fellow of the Royal Society in 2021. Platt was interested
Arnon Rosenthal (152 words) [view diff] exact match in snippet view article find links to article
develops innate immune (immuno-neurology) drugs for dementia and neurodegeneration, in 2013. Pollack, Andrew (April 7, 2006). "Pfizer to Buy Rinat, a
Substantia nigra (5,007 words) [view diff] exact match in snippet view article find links to article
calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration". Neurodegeneration. 5 (4): 313–8. doi:10.1006/neur.1996.0042. PMID 9117542
Bradlee Heckmann (1,064 words) [view diff] exact match in snippet view article find links to article
pathway is protective against β-amyloid induced neuroinflammation and neurodegeneration, work recently published in Cell and featured in mainstream media
Mir-219 microRNA precursor family (373 words) [view diff] exact match in snippet view article find links to article
Crary JF (February 2015). "Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau". The Journal of Clinical
SCYL1 (1,172 words) [view diff] exact match in snippet view article find links to article
of muscle deficient mice (mdf mice) that suffer from a progressive neurodegeneration of the cerebellum and lower motor neurons. Mdf mice model human spinocerebellar
Glycation (927 words) [view diff] exact match in snippet view article find links to article
Gasic-Milenkovic J. (2002). "Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease--a target for neuroprotective treatment strategies
Arthropod defensin (1,254 words) [view diff] exact match in snippet view article find links to article
Overactive immune signalling is also implicated in age-associated neurodegeneration, and overexpression of defensin leads to increased degradation of
R7 (drug) (717 words) [view diff] exact match in snippet view article
treating various BDNF-implicated human disorders". Translational Neurodegeneration. 5 (1): 2. doi:10.1186/s40035-015-0048-7. ISSN 2047-9158. PMC 4702337
Neuropathy target esterase (1,764 words) [view diff] exact match in snippet view article find links to article
autosomal-recessive spastic paraplegia. The protein is also the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents
GRIK4 (652 words) [view diff] exact match in snippet view article find links to article
(December 2008). "Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor". J. Cell
Centers and institutes of Washington University in St. Louis (1,977 words) [view diff] exact match in snippet view article find links to article
Infectious Disease Research Hope Center Program on Protein Folding and Neurodegeneration Center for Interdisciplinary Studies of Diabetic Cardiovascular Disease
Michael I. Miller (2,207 words) [view diff] no match in snippet view article find links to article
Michael Ira Miller (born 1955) is an American-born biomedical engineer and data scientist, and the Bessie Darling Massey Professor and Director of the
Pannexin (1,041 words) [view diff] exact match in snippet view article find links to article
Barakat W, et al. (December 2011). "Pannexins in ischemia-induced neurodegeneration". Proceedings of the National Academy of Sciences of the United States
Pathophysiology of Parkinson's disease (2,177 words) [view diff] exact match in snippet view article find links to article
Dreses-Werringloer U, Vingtdeux V (2009). "Calcium signaling in neurodegeneration". Mol Neurodegeneration. 4 (1): 20. doi:10.1186/1750-1326-4-20. Barnett MW, Larkman
Paul A. Sieving (921 words) [view diff] exact match in snippet view article find links to article
studies of human progressive, blinding, inherited retinal and macular neurodegeneration diseases, including retinitis pigmentosa and Stargardt disease.  His
MTOR (12,966 words) [view diff] exact match in snippet view article find links to article
through synaptic plasticity. Further evidence for mTOR activity in neurodegeneration comes from recent findings demonstrating that eIF2α-P, an upstream
List of medical abbreviations: N (0 words) [view diff] exact match in snippet view article find links to article
(please pay attention) (from Latin nota bene) NBN newborn nursery NBIA neurodegeneration with brain iron accumulation NBT nitroblue tetrazolium NBTE nonbacterial
Glycoside hydrolase family 29 (644 words) [view diff] exact match in snippet view article find links to article
fucosidosis, a lysosomal storage disorder characterised by rapid neurodegeneration, resulting in severe mental and motor deterioration. The enzyme is
Alpha-synuclein (8,464 words) [view diff] exact match in snippet view article find links to article
(November 2005). "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration". Cell. 123 (3): 383–96. doi:10.1016/j.cell.2005.09.028. PMID 16269331
GRIN3B (883 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : A Journal for Neurodegenerative Disorders, Neuroprotection, and
David Sulzer (4,679 words) [view diff] exact match in snippet view article find links to article
optically measure neurotransmission, and has introduced new hypotheses of neurodegeneration in Parkinson's disease, and changes in synapses that produce autism
Cholesterol signaling (1,155 words) [view diff] exact match in snippet view article find links to article
effects are most notable in inflammation, metabolic syndrome, and neurodegeneration. At the molecular level, cholesterol primarily signals by regulating
Copper deficiency (2,740 words) [view diff] exact match in snippet view article find links to article
copper deficiency. T2 signalling is often an indicator of some kind of neurodegeneration. There are some changes in the spinal cord MRI involving the thoracic
Familial British dementia (152 words) [view diff] exact match in snippet view article find links to article
B; et al. (2001). "Chromosome 13 dementia syndromes as models of neurodegeneration". Amyloid. 8 (4): 277–84. doi:10.3109/13506120108993826. PMID 11791622
Dependence receptor (1,431 words) [view diff] exact match in snippet view article find links to article
developmental cell death, carcinogenesis (especially metastasis), neurodegeneration, and possibly non-lethal (sub-apoptotic) events such as neurite retraction
VAC14 (934 words) [view diff] exact match in snippet view article find links to article
knock-out mice die at, or shortly after birth and exhibit massive neurodegeneration. Fibroblasts from these mice display ~50% lower levels of PtdIns(3
Kufor–Rakeb syndrome (1,343 words) [view diff] exact match in snippet view article find links to article
basal ganglia. This accumulation of iron is referred to as NBIA, or neurodegeneration with brain iron accumulation, and it is a symptom unique to a complex
7β-Hydroxyepiandrosterone (237 words) [view diff] exact match in snippet view article find links to article
Hanin I, Rose M, Wülfert E (2004). "Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid"
Farnesyltransferase inhibitor (1,079 words) [view diff] exact match in snippet view article find links to article
Rev Cancer, 3:11-22 Link Medicine: Exploring a new mechanism for neurodegeneration Eastman RT, Buckner FS, Yokoyama K, Gelb MH, Van Voorhis WC (February
Α5IA (281 words) [view diff] exact match in snippet view article find links to article
of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease". Heliyon. 7 (9):
Amyloid beta (6,808 words) [view diff] exact match in snippet view article find links to article
Amyloid beta deposition is associated with L-arginine deprivation and neurodegeneration. Mice treated with Norvaline display improved spatial memory, increased
Crick Lecture (468 words) [view diff] exact match in snippet view article find links to article
Muqit in recognition of his research on cell signalling linked to neurodegeneration in Parkinson’s disease 2017 Simon Myers [Wikidata] for transforming
O-linked glycosylation (3,150 words) [view diff] exact match in snippet view article find links to article
diseases known as sphingolipidoses, which are often characterised by neurodegeneration and developmental disabilities. Because both galactose and glucose
Sharon Moalem (2,238 words) [view diff] exact match in snippet view article find links to article
aureus (MRSA). Moalem was the first to propose that the progressive neurodegeneration associated with dementia and Alzheimer's disease might be caused or
ITK-SNAP (987 words) [view diff] exact match in snippet view article find links to article
L. G.; Thompson, P. M. (2007). "Brain mapping as a tool to study neurodegeneration". Neurotherapeutics. 4 (3): 387–400. doi:10.1016/j.nurt.2007.05.009
GRID1 (717 words) [view diff] exact match in snippet view article find links to article
linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9
MAPK13 (1,013 words) [view diff] exact match in snippet view article find links to article
reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL". Hum. Mol. Genet. 15 (11): 1826–34. doi:10.1093/hmg/ddl105
GRIN2D (1,083 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. Akbarian
Kininogen (1,644 words) [view diff] exact match in snippet view article find links to article
Peter (2012-11-08). "Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation"
Niemann–Pick disease (2,920 words) [view diff] exact match in snippet view article find links to article
old, they showed marked improvement in liver function, much less neurodegeneration and ultimately, they lived longer lives than the mice who did not
GRIN3A (1,017 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. Pittaluga
Mark L. Nelson (648 words) [view diff] exact match in snippet view article find links to article
showing promise against the secondary effects of stroke, hypoxia and neurodegeneration, in studies funded by the Department of Defense, with Marc Halterman
Michelle Gray (2,306 words) [view diff] exact match in snippet view article find links to article
2008, Gray joined the University of Alabama Birmingham Center for Neurodegeneration and Experimental Therapeutics (CNET) in the Department of Neurology
Parthanatos (3,625 words) [view diff] exact match in snippet view article find links to article
6-tetrahydropyridine (MPTP) is a neurotoxin that has been linked to neurodegeneration and development of Parkinson Disease-like symptoms in patients since
FA2H (821 words) [view diff] exact match in snippet view article find links to article
or without dystonia as well as fatty acid hydroxylase-associated neurodegeneration. The largest cohort with a detailed phenotypical description and a
Farah Lubin (2,424 words) [view diff] exact match in snippet view article find links to article
these mechanisms are altered in disease states such as epilepsy and neurodegeneration. Lubin discovered the role of NF-κB in fear memory reconsolidation
Eutropoflavin (324 words) [view diff] exact match in snippet view article find links to article
treating various BDNF-implicated human disorders". Translational Neurodegeneration. 5 (1): 2. doi:10.1186/s40035-015-0048-7. PMC 4702337. PMID 26740873
Julie C. Price (2,903 words) [view diff] exact match in snippet view article find links to article
biological markers of health and disease in studies of aging and neurodegeneration, including studies of glucose metabolism, protein expression, neurotransmitter
Beta-Methylamino-L-alanine (2,547 words) [view diff] exact match in snippet view article find links to article
also found that newborn rats treated with BMAA show a progressive neurodegeneration in the hippocampus, including intracellular fibrillar inclusions,
Drosophila melanogaster (15,775 words) [view diff] exact match in snippet view article find links to article
also been implicated in processes regarding cell proliferation and neurodegeneration either through autophagy, or autoimmune toxicity. In neurodegenerative
International Max Planck Research School for Molecular and Cellular Life Sciences (646 words) [view diff] exact match in snippet view article find links to article
Bio-imaging Computational Biology Gene Regulation Immunology Neurobiology Neurodegeneration Protein Structure Signaling Systems Biology Although students specialize
Cathepsin L (321 words) [view diff] exact match in snippet view article find links to article
Pennacchio LA, Peters C, Reinheckel T.Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem. 2006
Mir-8/mir-141/mir-200 microRNA precursor family (866 words) [view diff] exact match in snippet view article find links to article
(2007). "The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila". Cell. 131 (1): 136–45. doi:10.1016/j.cell.2007.09
PARP inhibitor (1,757 words) [view diff] exact match in snippet view article find links to article
may exacerbate the pathogenesis of stroke, myocardial infarction, neurodegeneration, and a number of other disease conditions due to excessive inflammation
Protein aggregation (2,463 words) [view diff] exact match in snippet view article find links to article
signaling (IIS), a prominent aging regulatory pathway protects from neurodegeneration-linked toxic protein aggregation. The validity of this approach has
Protein aggregation (2,463 words) [view diff] exact match in snippet view article find links to article
signaling (IIS), a prominent aging regulatory pathway protects from neurodegeneration-linked toxic protein aggregation. The validity of this approach has
Arthur L. Horwich (1,042 words) [view diff] exact match in snippet view article find links to article
chaperone assisted protein folding in the cell and its relevance to neurodegeneration". 2007: Received Wiley Prize in Biomedical Science jointly with Franz-Ulrich
ASIC2 (984 words) [view diff] exact match in snippet view article find links to article
amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans". The Journal of Biological Chemistry. 271
Norvaline (788 words) [view diff] exact match in snippet view article find links to article
Amyloid-beta deposition is associated with L-arginine deprivation and neurodegeneration. Mice treated with Norvaline display improved spatial memory, increased
HDAC6 (1,452 words) [view diff] exact match in snippet view article find links to article
the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration". Autophagy. 3 (6): 643–5. doi:10.4161/auto.5050. PMID 17912024. Pandey
Retromer (1,571 words) [view diff] exact match in snippet view article find links to article
deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation". Proceedings of the National Academy of Sciences
Superoxide dismutase mimetics (1,612 words) [view diff] exact match in snippet view article find links to article
stress and cell damage, which has been linked to causing cancers, neurodegeneration, age-related declines in health, and inflammatory diseases. SOD mimetics
Superoxide (1,489 words) [view diff] exact match in snippet view article find links to article
lacking mitochondrial SOD (MnSOD) die around 21 days after birth due to neurodegeneration, cardiomyopathy, and lactic acidosis. Mice lacking cytosolic SOD (CuZnSOD)
Glycerophospholipid (1,783 words) [view diff] exact match in snippet view article find links to article
peroxides and compromised energy metabolism may be responsible for the neurodegeneration observed in neurological disorders. The metabolism of glycerophospholipids
Pure autonomic failure (533 words) [view diff] exact match in snippet view article find links to article
It is relevant to note that progression to central nervous system neurodegeneration can also occur. It is also known as Bradbury-Eggleston syndrome, named
GRIN2C (1,125 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. Pittaluga
Diptericin (1,132 words) [view diff] exact match in snippet view article find links to article
and other antimicrobial peptides in the brains of flies leads to neurodegeneration. The Drosophila diptericin B gene is required for memory formation
OMA1 (649 words) [view diff] exact match in snippet view article find links to article
the fusion of the mitochondrial network. OMA1 seems to play role in neurodegeneration Several mutations in OMA1 were identified in Amyotrophic Lateral Sclerosis
Role of microglia in disease (5,042 words) [view diff] exact match in snippet view article find links to article
responses and neuronal degradation. Cytokines play a potential role in neurodegeneration when microglia remain in a sustained activated state. This is in contrast
NFE2L1 (3,647 words) [view diff] exact match in snippet view article find links to article
studies may provide therapeutic efforts involving Nfe2l1 for cancer, neurodegeneration, and metabolic diseases. GRCh38: Ensembl release 89: ENSG00000082641
Amyotrophic lateral sclerosis research (2,123 words) [view diff] exact match in snippet view article find links to article
Vérièpe, Julie; Fossouo, Lucresse; Parker, J. Alex (2015-06-10). "Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation
Alzheimer's Drug Discovery Foundation (1,193 words) [view diff] exact match in snippet view article find links to article
Conference on Alzheimer's Drug Discovery and the Drug Discovery for Neurodegeneration Conference. The ADDF also organizes advisory panels focused on key
Panayiotis Vlamos (386 words) [view diff] exact match in snippet view article find links to article
a Greek mathematician who studies mathematics, bioinformatics and neurodegeneration. He is Professor of Mathematics and Head of the Department of Informatics
Multisynthetase complex auxiliary component p38 (945 words) [view diff] exact match in snippet view article find links to article
synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Human Molecular Genetics. 12 (12): 1427–37. doi:10.1093/hmg/ddg159
Oligonucleotide (1,869 words) [view diff] exact match in snippet view article find links to article
SL, Miller TM (July 2013). "Antisense oligonucleotides: treating neurodegeneration at the level of RNA". Neurotherapeutics. 10 (3): 486–97. doi:10
Forsythia suspensa (383 words) [view diff] exact match in snippet view article find links to article
treating various diseases, including inflammation, virus infection, neurodegeneration, oxidative stress, liver injury, and bacterial infection. "Forsythia
Pathophysiology (2,697 words) [view diff] exact match in snippet view article find links to article
immune cells invade the central nervous system and cause inflammation, neurodegeneration and tissue damage. The underlying condition that produces this behaviour
GPR17 (1,797 words) [view diff] exact match in snippet view article find links to article
2016). "An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration". Neuropharmacology. 104: 4–17
Hypertryptophanemia (1,048 words) [view diff] exact match in snippet view article find links to article
GM, Stoy N, Darlington LG (December 2007). "Tryptophan, adenosine, neurodegeneration and neuroprotection". Metabolic Brain Disease. 22 (3–4): 337–352.
SCH-58261 (865 words) [view diff] exact match in snippet view article find links to article
brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration". Journal of Neuropathology and Experimental Neurology. 66 (5): 363–71
WD40 repeat (956 words) [view diff] exact match in snippet view article find links to article
NBIA5; WDRX1; WIPI4; WIPI-4 11152 Beta-propeller protein-associated neurodegeneration (BPAN) WDR46 UTP7; BING4; FP221; C6orf11 9277 WDR47 NEMITIN; KIAA0893
PERK inhibitors (225 words) [view diff] exact match in snippet view article find links to article
Scheper, W.; Hoozemans, J. J. M. (2013). "A New PERKspective on Neurodegeneration". Science Translational Medicine. 5 (206): 206fs37. doi:10.1126/scitranslmed
AIM center (470 words) [view diff] exact match in snippet view article find links to article
at times of starvation. Autophagy has been implicated in cancer, neurodegeneration such as Alzheimer's disease, Huntington's disease and Parkinson's
David R. Brown (neuroscientist) (836 words) [view diff] exact match in snippet view article
Horwood Press, Chichester, UK. ISBN 1-898563-87-X. Brown D. R. (2005) Neurodegeneration and Prion Disease. Springer, USA. ISBN 0-387-23922-7. Kozlowski, H
Pericyte (3,977 words) [view diff] exact match in snippet view article find links to article
perfusion and maintenance of the blood–brain barrier, which causes neurodegeneration and neuroinflammation. The apoptosis of pericytes in the aging brain
Hypothermia therapy for neonatal encephalopathy (5,596 words) [view diff] exact match in snippet view article find links to article
present in variable proportions; and there seems to be prolonged neurodegeneration after an insult. Research into this problem continues. These ideas
Neurturin (1,456 words) [view diff] exact match in snippet view article find links to article
it a popular candidate for the potential treatment or reversal of neurodegeneration. In addition, mice models have shown the dying neurons exposed to
Elizabeth Fisher (neuroscientist) (1,153 words) [view diff] exact match in snippet view article
mammalian model of the link between defects in retrograde transport and neurodegeneration. In a paper published in Science, Fisher found that two spontaneous
Sphingolipidoses (650 words) [view diff] exact match in snippet view article find links to article
adulthood Tay–Sachs disease Hexosaminidase A GM2 gangliosides in neurons Neurodegeneration Developmental disability Early death Autosomal recessive Approximately
Ferritin light chain (1,882 words) [view diff] exact match in snippet view article find links to article
"Expression of a Mutant Form of the Ferritin Light Chain Gene Induces Neurodegeneration and Iron Overload in Transgenic Mice". The Journal of Neuroscience
Low-affinity nerve growth factor receptor (4,042 words) [view diff] exact match in snippet view article find links to article
dismutase 1 (SOD1) mutant mouse, an ALS model which develops severe neurodegeneration, the expression of p75NTR correlated with the extent of degeneration
Virginia Man-Yee Lee (863 words) [view diff] exact match in snippet view article find links to article
ALS/FTD, respectively, elucidating the roles of these proteins in neurodegeneration, pursuing pathological tau as a target for AD and FTD drug discovery
Notch signaling pathway (9,263 words) [view diff] exact match in snippet view article find links to article
signaling is also involved in neuronal apoptosis, neurite retraction, and neurodegeneration of ischemic stroke in the brain In addition to developmental functions
Protein phosphatase (2,181 words) [view diff] exact match in snippet view article find links to article
has been linked to several disorders including cognitive ageing and neurodegeneration, as well as cancer, diabetes and obesity. Human genes that encode
D-Amino acid (1,563 words) [view diff] exact match in snippet view article find links to article
2008). "D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration". The FEBS Journal. 275 (14): 3514–26. doi:10.1111/j.1742-4658.2008
Galactose (2,048 words) [view diff] exact match in snippet view article find links to article
2006). "Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic
MFN2 (3,222 words) [view diff] exact match in snippet view article find links to article
JM, Chan DC (August 2007). "Mitochondrial fusion protects against neurodegeneration in the cerebellum". Cell. 130 (3): 548–62. doi:10.1016/j.cell.2007
Complement component 5a (1,436 words) [view diff] exact match in snippet view article find links to article
"Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration". FASEB Journal. 20 (9): 1407–17. doi:10.1096/fj.05-5814com. PMID 16816116
GRIN1 (1,045 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : A Journal for Neurodegenerative Disorders, Neuroprotection, and
Synucleinopathy (965 words) [view diff] exact match in snippet view article find links to article
EL, et al. (October 2014). "Alpha-synuclein and tau: teammates in neurodegeneration?". Mol Neurodegener. 9: 43. doi:10.1186/1750-1326-9-43. PMC 4230508
14-3-3 protein (1,162 words) [view diff] exact match in snippet view article find links to article
Steinacker P, Aitken A, Otto M (September 2011). "14-3-3 proteins in neurodegeneration". Seminars in Cell & Developmental Biology. 22 (7): 696–704. doi:10
Huperzine A (1,278 words) [view diff] exact match in snippet view article find links to article
investigated as a possible treatment for diseases characterized by neurodegeneration, particularly Alzheimer's disease. A 2013 meta-analysis found that
Purinergic receptor (1,387 words) [view diff] exact match in snippet view article find links to article
thereby mediating the effects of neural activity during development, neurodegeneration, inflammation, and cancer. Both of these metabotropic receptors are
Prion (9,082 words) [view diff] exact match in snippet view article find links to article
(for Scrapie), after one of the diseases first linked to prions and neurodegeneration. The precise structure of the prion is not known, though they can
Rasagiline (1,895 words) [view diff] exact match in snippet view article find links to article
disease expert: Rasagiline and the future of therapy" (PDF). Molecular Neurodegeneration. 2 (1): 13. doi:10.1186/1750-1326-2-13. PMC 1929084. PMID 17617893
List of centers and institutes at the Perelman School of Medicine (908 words) [view diff] exact match in snippet view article find links to article
(Department of Medicine) – http://www.uphs.upenn.edu/lungctr/ Penn Neurodegeneration Genomics Center (Department of Pathology and Laboratory Medicine)
PSMA7 (3,227 words) [view diff] exact match in snippet view article find links to article
Recent study on underlying mechanisms of E3 ligase Parkin-related neurodegeneration identified this proteasome subunit as one of Parkin associating partner
Necroptosis (1,568 words) [view diff] exact match in snippet view article find links to article
contribute to atherosclerosis, pancreatitis, inflammatory bowel disease, neurodegeneration, and some cancers. In solid-organ transplantation, ischemia-reperfusion
5-Fluorowillardiine (1,203 words) [view diff] exact match in snippet view article find links to article
"The effects of AMPA receptor antagonists in models of stroke and neurodegeneration". European Journal of Pharmacology. 519 (1–2): 58–67. doi:10.1016/j
Dolichol (834 words) [view diff] exact match in snippet view article find links to article
Edlund C, Söderberg M, Kristensson K (1994). "Isoprenoids in aging and neurodegeneration". Neurochem. Int. 25 (1): 35–38. doi:10.1016/0197-0186(94)90050-7
Robert Moir (1,105 words) [view diff] exact match in snippet view article find links to article
Lab focused on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and ageing. Moir was married twice. First to
Breakthrough Prize in Life Sciences (1,982 words) [view diff] exact match in snippet view article find links to article
pathogenesis of a type of inherited ALS, including the role of glia in neurodegeneration, and for establishing antisense oligonucleotide therapy in animal
Isomerase (3,578 words) [view diff] exact match in snippet view article find links to article
glycolyic metabolism. It is characterized by hemolytic anemia and neurodegeneration, and is caused by anaerobic metabolic dysfunction. This dysfunction
List of centers and institutes at the Perelman School of Medicine (908 words) [view diff] exact match in snippet view article find links to article
(Department of Medicine) – http://www.uphs.upenn.edu/lungctr/ Penn Neurodegeneration Genomics Center (Department of Pathology and Laboratory Medicine)
Tau protein (6,076 words) [view diff] exact match in snippet view article find links to article
effects on microtubule interaction, intracellular trafficking and neurodegeneration". The Biochemical Journal. 323 ( Pt 3) (3): 577–91. doi:10.1042/bj3230577
Breakthrough Prize in Life Sciences (1,982 words) [view diff] exact match in snippet view article find links to article
pathogenesis of a type of inherited ALS, including the role of glia in neurodegeneration, and for establishing antisense oligonucleotide therapy in animal
Cerebral amyloid angiopathy (1,661 words) [view diff] exact match in snippet view article find links to article
PMID 12146803. S2CID 8930792. Dickson, Dennis; Weller, Roy O. (2011-09-09). Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. John
Robert Moir (1,105 words) [view diff] exact match in snippet view article find links to article
Lab focused on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and ageing. Moir was married twice. First to
MAFF (gene) (1,839 words) [view diff] exact match in snippet view article
in the onset and progression of various human diseases, including neurodegeneration, arteriosclerosis and cancer. MAF (gene) GRCh38: Ensembl release 89:
L-DOPA (2,435 words) [view diff] exact match in snippet view article find links to article
PMID 24374199. Rodgers, KJ (March 2014). "Non-protein amino acids and neurodegeneration: the enemy within". Experimental Neurology. 253: 192–6. doi:10.1016/j
Nizofenone (480 words) [view diff] exact match in snippet view article find links to article
articles should be added in references: Yasuda H (1999). Prevention of neurodegeneration by a neuroprotective radical scavenger. Ann N Y Acad Sci. 893: 430-3
TAR DNA-binding protein 43 (3,315 words) [view diff] exact match in snippet view article find links to article
characterization of soluble human full-length TDP-43 associated with neurodegeneration". FASEB J. 33 (10): 10780–93. doi:10.1096/fj.201900474R. PMID 31287959
Inborn errors of carbohydrate metabolism (1,875 words) [view diff] exact match in snippet view article find links to article
Unclear role in: Alzheimer's Mild cognitive impairment Schizophrenia Neurodegeneration, unclear role. See respective conditions See respective conditions
Anne Schaefer (scientist) (2,895 words) [view diff] exact match in snippet view article
diseases where aberrantly activated microglia lead to over-pruning and neurodegeneration. To understand more deeply what drives the unique epigenetic programming
BCKDHA (2,088 words) [view diff] exact match in snippet view article find links to article
buildup of these amino acids lead to “encephalopathy and progressive neurodegeneration”; along with other complications. There are five forms of maple syrup
GSK-3 (5,227 words) [view diff] exact match in snippet view article find links to article
Alzheimer's and other neurodegenerative diseases such as epileptic neurodegeneration. Naproxen is a non-steroidal anti-inflammatory drug while cromolyn
Arimoclomol (827 words) [view diff] exact match in snippet view article find links to article
the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects". Cell. Mol. Biol
Paul Schimmel (1,118 words) [view diff] exact match in snippet view article find links to article
"Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration". Nature. 443 (7107): 50–55. doi:10.1038/nature05096. ISSN 1476-4687
IDH3B (1,728 words) [view diff] exact match in snippet view article find links to article
mutations of the IDH3B gene has been linked to retinitis pigmentosa, the neurodegeneration of rods and cones in the retina resulting in blindness. Click on genes
Choroid plexus (1,811 words) [view diff] exact match in snippet view article find links to article
Baruch K (January 2014). "The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus". The EMBO Journal.
GRIN2B (1,907 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. Niethammer
24-Dehydrocholesterol reductase (1,160 words) [view diff] exact match in snippet view article find links to article
homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress". J. Neurosci. 20 (19): 7345–52. doi:10.1523/JNEUROSCI
Sterol regulatory element-binding protein (2,061 words) [view diff] exact match in snippet view article find links to article
and regulates a wide range of processes ranging from development to neurodegeneration. A feature of the SREBP pathway is the proteolytic release of a membrane-bound
Jackson Laboratory (1,581 words) [view diff] exact match in snippet view article find links to article
disease Jackson Laboratory researchers discover mutation involved in neurodegeneration The Jackson Laboratory for Genomic Medicine opens in Farmington, CT
MAFK (2,533 words) [view diff] exact match in snippet view article find links to article
in the onset and progression of various human diseases, including neurodegeneration, arteriosclerosis and cancer. GRCh38: Ensembl release 89: ENSG00000198517
Tameka A. Clemons (1,163 words) [view diff] exact match in snippet view article find links to article
beta-cell death might be prevented. This work extends to the field of neurodegeneration, as Clemons also hopes to explore how UCP2 could be used to control
TREM2 (878 words) [view diff] exact match in snippet view article find links to article
insights into the role of TREM2 in Alzheimer's disease". Molecular Neurodegeneration. 13 (1): 66. doi:10.1186/s13024-018-0298-9. PMC 6302500. PMID 30572908
Howard University College of Medicine (1,206 words) [view diff] exact match in snippet view article find links to article
Deborah; Bond, Vernon; Kwagyan, John (2012). "Neuroprotection and Neurodegeneration in Alzheimer's Disease: Role of Cardiovascular Disease Risk Factors
Proteolipid protein 1 (1,165 words) [view diff] exact match in snippet view article find links to article
"Proteolipid protein gene: Pelizaeus-Merzbacher disease in humans and neurodegeneration in mice". Trends Genet. 15 (4): 125–8. doi:10.1016/S0168-9525(99)01716-3
Phosphomimetics (642 words) [view diff] exact match in snippet view article find links to article
Dawson (2014). "Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease". Cell. 157 (2): 472–485. doi:10.1016/j.cell
Neuroscience Research Australia (689 words) [view diff] exact match in snippet view article find links to article
NeuRA’s research activity is organised into five themes: Ageing and neurodegeneration: Alzheimer's disease, frontotemporal dementia and other types of dementia
Seymour Benzer (2,403 words) [view diff] exact match in snippet view article find links to article
products regulated behavior. Benzer was at the forefront of the study of neurodegeneration in fruit flies, modeling human diseases and attempting to suppress
Interleukin 4 (2,027 words) [view diff] exact match in snippet view article find links to article
crosstalk between the neural stem cells and neurons that undergo neurodegeneration, and initiate a regeneration cascade through phosphorylation of its
Pramipexole (1,865 words) [view diff] exact match in snippet view article find links to article
2008). "Cognitive impairment in bipolar disorder: Neurodevelopment or neurodegeneration? An ECNP expert meeting report". European Neuropsychopharmacology
Solanezumab (1,445 words) [view diff] exact match in snippet view article find links to article
Lifestyle (AIBL) Research Group) (April 2013). "Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective
Muscarinic acetylcholine receptor M1 (2,021 words) [view diff] exact match in snippet view article find links to article
(February 2017). "M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss". The Journal of Clinical Investigation. 127
Binge drinking (9,318 words) [view diff] exact match in snippet view article find links to article
animal studies find that heavy and regular binge drinking causes neurodegeneration in corticolimbic brain regions areas that are involved in learning
GRIN2A (1,987 words) [view diff] exact match in snippet view article find links to article
receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564. Niethammer
Valina L. Dawson (3,384 words) [view diff] exact match in snippet view article find links to article
(December 1999). "Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease". Nature Medicine. 5 (12):
Solanezumab (1,445 words) [view diff] exact match in snippet view article find links to article
Lifestyle (AIBL) Research Group) (April 2013). "Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective
CREB (2,175 words) [view diff] exact match in snippet view article find links to article
Schütz G (2002). "Disruption of CREB function in brain leads to neurodegeneration". Nat. Genet. 31 (1): 47–54. doi:10.1038/ng882. PMID 11967539. S2CID 22014116
Prenol (678 words) [view diff] exact match in snippet view article find links to article
Söderberg, M.; Kristensson, K. (1994), "Isoprenoids in aging and neurodegeneration", Neurochem. Int., 25 (1): 35–38, doi:10.1016/0197-0186(94)90050-7
Sam Gandy (1,291 words) [view diff] exact match in snippet view article find links to article
Beene | Sam Gandy". Retrieved 2020-01-22. "Molecular Neurodegeneration". Molecular Neurodegeneration. Retrieved 2020-01-22. "Samuel Gandy - Google Scholar"
Biogen (2,814 words) [view diff] exact match in snippet view article find links to article
cutting 11% of its workforce". "Biogen and Sangamo Ink $2.7 Billion+ Neurodegeneration Deal". BioSpace. Retrieved 2020-02-28. Report, Staff. "Biotech company
5-HT5A receptor (1,590 words) [view diff] exact match in snippet view article find links to article
of Dimebon in cellular model of Huntington's disease". Molecular Neurodegeneration. 3 (1): 15. doi:10.1186/1750-1326-3-15. PMC 2577671. PMID 18939977
Léo-Pariseau Prize (692 words) [view diff] exact match in snippet view article find links to article
neurosciences, Université de Montréal 2013 - Jean-Pierre Julien, neurodegeneration, Université Laval 2014 - Marc-André Sirard, animal reproduction, Université
Synaptic plasticity (3,606 words) [view diff] exact match in snippet view article find links to article
York: Penguin Books. pp. 1–324. Overview Finnerty lab, MRC Centre for Neurodegeneration Research, London Brain Basics Synaptic Plasticity Synaptic transmission
Bryce Vissel (780 words) [view diff] exact match in snippet view article find links to article
2019. "The role of glutamate receptor mediated excititoxicity in neurodegeneration and Huntington's disease". Research Data Australia. Retrieved 15 February
Pamela Shaw (370 words) [view diff] exact match in snippet view article find links to article
involving neurology. She specialises in the "molecular mechanisms of neurodegeneration and neuroprotection in disorders of the motor system (motor neurone
Visual release hallucinations (2,188 words) [view diff] exact match in snippet view article find links to article
Bonnet's honor. De Morsier’s description of CBS implies a concentrated neurodegeneration, usually occurring in the elderly with typical cognition. In 1936
Chlorella (1,918 words) [view diff] exact match in snippet view article find links to article
(2007). "Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration". Glia. 55 (5): 453–62. doi:10.1002/glia.20467. PMC 2871685. PMID 17203472
Praobdellidae (264 words) [view diff] exact match in snippet view article find links to article
(2007) Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration. PLoS Genet 3(5): e82. doi:10.1371/journal.pgen.0030082 IRMNG: taxon
Biotin (4,933 words) [view diff] exact match in snippet view article find links to article
remyelination of the myelin sheath of nerve cells, slowing or even reversing neurodegeneration. The proposed mechanisms are that biotin activates acetyl-coA carboxylase
Scyllo-Inositol (600 words) [view diff] exact match in snippet view article find links to article
Ethnobotanical Databases Aβ Busters and Other Ploys Show Promise for Treating Neurodegeneration McLaurin, Joanne; Kierstead, Meredith E.; Brown, Mary E.; Hawkes,
Proteopathy (4,529 words) [view diff] exact match in snippet view article find links to article
PMID 28108533. Prusiner SB (2013). "Biology and genetics of prions causing neurodegeneration". Annual Review of Genetics. 47: 601–23. doi:10.1146/annurev-genet-110711-155524
Pituitary pars intermedia dysfunction (2,501 words) [view diff] exact match in snippet view article find links to article
normally found in the pars intermedia. This is thought to be due to neurodegeneration of the neurons, secondary to free radical formation and oxidative
Dishevelled (1,358 words) [view diff] exact match in snippet view article find links to article
Wnt-Ca2+ pathway, which is involved in cancer, inflammation, and neurodegeneration. Wnt triggers Frizzled-mediated activation, triggering a cascade leading
Explant culture (740 words) [view diff] exact match in snippet view article find links to article
development has led the way for researchers to study pathological neurodegeneration and related retinal diseases more closely. Cellular grafts derived
Neuronal ceroid lipofuscinosis (4,407 words) [view diff] exact match in snippet view article find links to article
cells of the first six patients, as well as slowing down the rapid neurodegeneration of infantile NCL.Currently, two drug trials are underway for infantile
1996 in science (2,332 words) [view diff] exact match in snippet view article find links to article
ISBN 9780123518309. Bozyczko-Coyne, D.; Williams, M. (2007). "Neurodegeneration". Comprehensive Medicinal Chemistry II. pp. 193–228. doi:10
Latrepirdine (1,275 words) [view diff] exact match in snippet view article find links to article
of Dimebon in cellular model of Huntington's disease". Molecular Neurodegeneration. 3: 15. doi:10.1186/1750-1326-3-15. PMC 2577671. PMID 18939977. Gankina
Olfactory system (3,296 words) [view diff] exact match in snippet view article find links to article
Parkinson's Disease: Development of Optimal Discrimination Criteria". Neurodegeneration. 4 (1): 93–97. doi:10.1006/neur.1995.0011. PMID 7600189. Doty, R.
Dopamine receptor D1 (2,885 words) [view diff] exact match in snippet view article find links to article
receptor complex D1−H3−NMDAR receptor complex − a target to prevent neurodegeneration D1–D3 receptor complex D1–NMDAR receptor complex D1–A1 receptor complex
Myelin (3,834 words) [view diff] exact match in snippet view article find links to article
2012). "Oligodendroglia metabolically support axons and contribute to neurodegeneration". Nature. 487 (7408): 443–448. Bibcode:2012Natur.487..443L. doi:10
Eric M. Verdin (384 words) [view diff] exact match in snippet view article find links to article
of 103. Verdin, Eric (2015-12-04). "NAD+ in aging, metabolism, and neurodegeneration". Science. 350 (6265): 1208–1213. Bibcode:2015Sci...350.1208V. doi:10
UBB+1 (311 words) [view diff] exact match in snippet view article find links to article
N, Steinbusch HW, Van Leeuwen FW (2010). "Misframed proteins and neurodegeneration: a novel view on Alzheimer's and Parkinson's diseases". Neurodegener
Glia (3,584 words) [view diff] exact match in snippet view article find links to article
2008). "D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration". The FEBS Journal. 275 (14): 3514–26. doi:10.1111/j.1742-4658.2008
Immuno-psychiatry (1,946 words) [view diff] exact match in snippet view article find links to article
receptor activation and oxidative stress leading to excitotoxicity and neurodegeneration. Additionally, cytokines interferon-alpha and IL-6 can cause reversible
Inward-rectifier potassium channel (1,971 words) [view diff] exact match in snippet view article find links to article
Monte DA, Andersen JK (November 2006). "Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated
Methamphetamine (13,442 words) [view diff] exact match in snippet view article find links to article
studies on human methamphetamine users have also found evidence of neurodegeneration, or adverse neuroplastic changes in brain structure and function.
Ochratoxin A (2,444 words) [view diff] exact match in snippet view article find links to article
disease, and subchronic administration to rodents induces hippocampal neurodegeneration. Ochratoxin causes acute depletion of striatal dopamine, which constitutes
Multiple sclerosis biomarkers (7,716 words) [view diff] exact match in snippet view article find links to article
It seems that Fas and MIF are candidate biomarkers of progressive neurodegeneration. Upregulated levels of sFas (soluble form of Fas molecule) were found
Omigapil (2,239 words) [view diff] exact match in snippet view article find links to article
neuronal death, as well as in rodent and non-rodent animal models of neurodegeneration. Omigapil rescues in vitro PC12 cells from rotenone toxicity, β-amyloid
Long-term impact of alcohol on the brain (1,983 words) [view diff] exact match in snippet view article find links to article
"Alcohol inhibition of neurogenesis: A mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model". Hippocampus. 20 (5): 596–607
Lysosome (4,777 words) [view diff] exact match in snippet view article find links to article
Finkbeiner, Steven (1 April 2019). "The Autophagy Lysosomal Pathway and Neurodegeneration". Cold Spring Harbor Perspectives in Biology. 12 (3): a033993. doi:10
Nectarios (360 words) [view diff] exact match in snippet view article find links to article
known scientist in the fields of biology, cell biology, ageing, and neurodegeneration. "Definition of Nektar". Merriam-Webster. Venerable Nectarius of Optina
Inward-rectifier potassium channel (1,971 words) [view diff] exact match in snippet view article find links to article
Monte DA, Andersen JK (November 2006). "Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated
Institute of Psychiatry, Psychology and Neuroscience (2,444 words) [view diff] exact match in snippet view article find links to article
of Psychiatry now houses the Medical Research Council Centre for Neurodegeneration Research, where pioneering research is conducted investigating disease
PPT1 (1,112 words) [view diff] exact match in snippet view article find links to article
deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL". Hum. Mol. Genet. 15 (10): 1580–6. doi:10.1093/hmg/ddl078
SK channel (2,729 words) [view diff] exact match in snippet view article find links to article
substantia nigra compacta (SNc) neurons due to Parkinson’s-induced neurodegeneration, the number of these neurons can partially recover via a cell phenotype
Protein disulfide-isomerase (1,924 words) [view diff] exact match in snippet view article find links to article
Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration". Frontiers in Cell and Developmental Biology. 3: 80. doi:10.3389/fcell
Pathology of multiple sclerosis (17,118 words) [view diff] exact match in snippet view article find links to article
inflammation, myelin breakdown, astrogliosis, oligodendrocyte injury, neurodegeneration, axonal loss and remyelination. MS lesions evolve differently during
WIPI2 (774 words) [view diff] exact match in snippet view article find links to article
periods of nutrient deprivation and also plays a role in cancer, neurodegeneration and immune responses to a diverse range of pathogens. WIPI2 is recruited
Chlorocebus (2,253 words) [view diff] exact match in snippet view article find links to article
organism for studies of AIDS, microbiome, development, neurobehavior, neurodegeneration, metabolism and obesity. A genome of chlorocebus monkey (Chlorocebus
Manganism (2,033 words) [view diff] exact match in snippet view article find links to article
1011915108. PMC 3029707. PMID 21245347. Lucchini et al., "Metals and Neurodegeneration" — Research paper on heavy metals poisoning Antonini, James M. (2003)
MAFG (2,627 words) [view diff] exact match in snippet view article find links to article
in the onset and progression of various human diseases, including neurodegeneration, arteriosclerosis and cancer. GRCh38: Ensembl release 89: ENSG00000197063
Renã A. S. Robinson (1,938 words) [view diff] exact match in snippet view article find links to article
protein post-translational modifications implicated in neurodegeneration". Translational Neurodegeneration. 3 (1): 23. doi:10.1186/2047-9158-3-23. PMC 4323146
ATP7A (2,811 words) [view diff] exact match in snippet view article find links to article
this gene often cause copper deficiency, which leads to progressive neurodegeneration and death in children. ATP7A is a transmembrane protein with the N-
EMBO Gold Medal (901 words) [view diff] exact match in snippet view article find links to article
Aguzzi, A. (1998). "Grafting mouse brains: From neurocarcinogenesis to neurodegeneration". The EMBO Journal. 17 (21): 6107–6114. doi:10.1093/emboj/17.21.6107
List of investigational antidepressants (2,253 words) [view diff] exact match in snippet view article find links to article
treating various BDNF-implicated human disorders". Translational Neurodegeneration. 5: 2. doi:10.1186/s40035-015-0048-7. PMC 4702337. PMID 26740873.
Spinocerebellar ataxia type 6 (1,419 words) [view diff] exact match in snippet view article find links to article
[alpha]1A voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6". Hum Mol Genet. 8 (7): 1185–93.
SOX2 (3,368 words) [view diff] exact match in snippet view article find links to article
Sala M, DeBiasi S, Nicolis SK (August 2004). "Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain". Development.
Rajiv Ratan (1,619 words) [view diff] exact match in snippet view article find links to article
Program in Neuroscience as well as the Center for NeuroDiscovery in Neurodegeneration. He taught a course in the New Pathway and a seminar course on Transcriptional
Glucagon-like peptide-1 receptor (2,839 words) [view diff] exact match in snippet view article find links to article
availability to neurons and alters neuron function contributing to neurodegeneration and motor problems seen in Huntington's disease. The health of the
Vesicular monoamine transporter 2 (1,864 words) [view diff] exact match in snippet view article find links to article
"Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration". J. Neurosci. 27 (30): 8138–48. doi:10.1523/JNEUROSCI.0319-07.2007
SnRNP70 (1,427 words) [view diff] exact match in snippet view article find links to article
to autosomal dominant genetic mutations and trisomy 21". Molecular Neurodegeneration. 9: 15. doi:10.1186/1750-1326-9-15. PMC 4022210. PMID 24773620. Xiao
Post-traumatic stress disorder (19,483 words) [view diff] exact match in snippet view article find links to article
against neurodegeneration caused by the extended stress response that characterizes PTSD, but long-term use may actually promote neurodegeneration. As of
Granulin (3,175 words) [view diff] exact match in snippet view article find links to article
Mackenzie IR (January 2008). "Progranulin: normal function and role in neurodegeneration". Journal of Neurochemistry. 104 (2): 287–97. doi:10.1111/j.1471-4159
Personal Genome Project (1,232 words) [view diff] exact match in snippet view article find links to article
vivo, and finally test emerging hypotheses in experimental models of neurodegeneration. Human Genome Project Personal genomics Church GM (2005). "The personal
Harald Jockusch (1,445 words) [view diff] exact match in snippet view article find links to article
cell-matrix interactions in muscle and in the neuromuscular system; neurodegeneration Pathogenesis by misfolded proteins in plant and animal cells Gene
Syncytin-1 (2,018 words) [view diff] exact match in snippet view article find links to article
expression of the ERVW-1 locus in neural tissue is implicated in neurodegeneration and development of multiple sclerosis. Multiple sclerosis retrovirus
Interferon-alpha/beta receptor (2,615 words) [view diff] exact match in snippet view article find links to article
leprosy. Type I IFN is also being investigated for a potential role in neurodegeneration; loss of IFNAR expression prolonged survival in murine models of amyotrophic
Warren Alpert Foundation Prize (372 words) [view diff] exact match in snippet view article find links to article
seminal contributions to our understanding of neurotransmission and neurodegeneration.  Austria  United States 2013 Dr. David Botstein, Princeton University
Presenilin (2,118 words) [view diff] exact match in snippet view article find links to article
suggested to "represent a general convergent mechanism leading to neurodegeneration". Homologs have been identified and characterized in diverse eukaryotic
PANK1 (446 words) [view diff] exact match in snippet view article find links to article
kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol. Chem. 282 (38): 27984–93. doi:10.1074/jbc.M701915200
Tropoflavin (2,217 words) [view diff] exact match in snippet view article find links to article
treating various BDNF-implicated human disorders". Translational Neurodegeneration. 5 (1): 2. doi:10.1186/s40035-015-0048-7. PMC 4702337. PMID 26740873
SCNN1A (3,113 words) [view diff] exact match in snippet view article find links to article
1993). "Epithelial sodium channel related to proteins involved in neurodegeneration". Nature. 361 (6411): 467–70. Bibcode:1993Natur.361..467C. doi:10
PANK1 (446 words) [view diff] exact match in snippet view article find links to article
kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol. Chem. 282 (38): 27984–93. doi:10.1074/jbc.M701915200
Cardiolipin (3,390 words) [view diff] exact match in snippet view article find links to article
PMID 16260631. Dawson TM, Dawson VL (2003). "Molecular pathways of neurodegeneration in Parkinson's disease". Science. 302 (5646): 819–822. Bibcode:2003Sci
Signs and symptoms of HIV/AIDS (3,336 words) [view diff] exact match in snippet view article find links to article
la Grandmaison G, Force G, Keohane C (2001). "Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced
TAOK2 (986 words) [view diff] exact match in snippet view article find links to article
kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies". Acta Neuropathologica Communications. 6 (1):
Christian Haass (177 words) [view diff] exact match in snippet view article find links to article
Munich Laboratory for Neurodegenerative Disease Research Collaborative Research Center 596 - Molecular Mechanisms of Neurodegeneration Publications v t e
Lysophospholipase (710 words) [view diff] exact match in snippet view article find links to article
P (1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria
Paula Isabel da Silva Moreira (142 words) [view diff] exact match in snippet view article find links to article
the pathologic process of diabetes have also been studied by Moreira as important risk factors for neurodegeneration. Alzheimer Research Forum Profile
LRP1 (3,563 words) [view diff] exact match in snippet view article find links to article
"LRP1 shedding in human brain: roles of ADAM10 and ADAM17". Molecular Neurodegeneration. 4: 17. doi:10.1186/1750-1326-4-17. ISSN 1750-1326. PMC 2672942. PMID 19371428
Cyclopentenone prostaglandins (3,045 words) [view diff] exact match in snippet view article find links to article
"Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration". Annals of the New York Academy of Sciences. 1363: 125–37. doi:10
HSPA1L (2,301 words) [view diff] exact match in snippet view article find links to article
involvement in many pathological processes, such as oncogenesis, neurodegeneration, and senescence. In particular, overexpression of HSP72 has been linked
1-Octen-3-ol (614 words) [view diff] exact match in snippet view article find links to article
semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration". Proceedings of the National Academy of Sciences of the United States
Wernicke–Korsakoff syndrome (4,543 words) [view diff] exact match in snippet view article find links to article
PMID 31876326. Vetreno, Ryan Peter (2011). Thiamine deficiency-induced neurodegeneration and neurogenesis (PhD Thesis). Binghamton University. ISBN 978-1-124-75696-7
Gaucher's disease (3,262 words) [view diff] exact match in snippet view article find links to article
cytokine secretion as a result of sphingolipid accumulation, and neurodegeneration caused by the accumulation of glucosylsphingosine, a neurotoxin Heterozygotes
Primary age-related tauopathy (2,120 words) [view diff] exact match in snippet view article find links to article
2017). "Tau PET imaging: present and future directions". Molecular Neurodegeneration. 12 (1): 19. doi:10.1186/s13024-017-0162-3. ISSN 1750-1326. PMC 5319037
Parabiosis (1,773 words) [view diff] exact match in snippet view article find links to article
"Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration". Nature Reviews Neuroscience. 21 (2): 93–102. doi:10.1038/s41583-019-0255-9
Li-Huei Tsai (1,731 words) [view diff] exact match in snippet view article find links to article
"Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration". Nature. 402 (6762): 615–622. Bibcode:1999Natur.402..615P. doi:10
Proprioception (6,452 words) [view diff] exact match in snippet view article find links to article
disease is characterized by a decline in motor function as a result of neurodegeneration. It is likely that some of the symptoms of Parkinson's disease are
Memantine (3,093 words) [view diff] exact match in snippet view article find links to article
Takeda M, Winblad B (January 1999). "The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease". International
Protein kinase C zeta type (2,927 words) [view diff] exact match in snippet view article find links to article
isoform, PKCι/λ in the knock-out. Alteration in PKMζ may be involved in neurodegeneration Alzheimer's disease. Model organisms have been used in the study of
Oxidative stress (5,731 words) [view diff] exact match in snippet view article find links to article
VP, Chu CT (March 2011). "Nuclear transport, oxidative stress, and neurodegeneration". Int J Clin Exp Pathol. 4 (3): 215–29. PMC 3071655. PMID 21487518
Geraint Rees (1,366 words) [view diff] exact match in snippet view article find links to article
and with respect to eye movements. More recently, he has worked on neurodegeneration, collaborating with Sarah Tabrizi. His work on multivariate inference
The Darkest Minds (2,161 words) [view diff] exact match in snippet view article find links to article
dystopian future, a contagious disease called Idiopathic Adolescent Acute Neurodegeneration (IAAN) kills nearly 98% of all children and teenagers, leaving the
TIA1 (1,263 words) [view diff] exact match in snippet view article find links to article
PMID 18291657. Wolozin B, Ivanov P (November 2019). "Stress granules and neurodegeneration". Nature Reviews. Neuroscience. 20 (11): 649–666. doi:10.1038/s41583-019-0222-5
PIM1 (3,159 words) [view diff] exact match in snippet view article find links to article
a novel therapeutic strategy for Alzheimer's disease". Molecular Neurodegeneration. 11 (1): 52. doi:10.1186/s13024-016-0118-z. PMC 4944476. PMID 27412291
Annonacin (956 words) [view diff] exact match in snippet view article find links to article
Inhibitor of Mitochondrial Complex I, induces Nigral and Striatal Neurodegeneration in Rats: Possible Relevance for Atypical Parkinsonism in Guadeloupe"
GSTM3 (1,128 words) [view diff] exact match in snippet view article find links to article
(2005). "Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease". Mech. Ageing Dev. 126 (2):
PARL (997 words) [view diff] exact match in snippet view article find links to article
the mitochondria, thus promoting retinal ganglion cell death and neurodegeneration. PARL has been shown to interact with: PINK1, OPA1, and HAX1. GRCh38:
5-HT6 receptor (3,300 words) [view diff] exact match in snippet view article find links to article
of Dimebon in cellular model of Huntington's disease". Molecular Neurodegeneration. 3: 15. doi:10.1186/1750-1326-3-15. PMC 2577671. PMID 18939977. Ivachtchenko
Caspase 1 (2,311 words) [view diff] exact match in snippet view article find links to article
receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures". Brain, Behavior, and Immunity
Interleukin 17 (3,970 words) [view diff] exact match in snippet view article find links to article
Winer S, Lanctôt KL (March 2013). "Interleukin-17 in post-stroke neurodegeneration". Neuroscience and Biobehavioral Reviews. 37 (3): 436–47. doi:10.1016/j
LTN1 (338 words) [view diff] exact match in snippet view article find links to article
screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration". Proceedings of the National Academy of Sciences of the United States
Tyrosine hydroxylase (4,335 words) [view diff] exact match in snippet view article find links to article
S2CID 46062969. Steinacker P, Aitken A, Otto M (Sep 2011). "14-3-3 proteins in neurodegeneration". Seminars in Cell & Developmental Biology. 22 (7): 696–704. doi:10