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Small fiber peripheral neuropathy
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and the SCN10A gene instructs the production of the alpha subunit for the NaV1.8 sodium channel. Sodium channels transport positively charged sodium atomsMarcos Ramírez (motorcyclist) (966 words) [view diff] no match in snippet view article
Year Bike 1 2 3 4 5 6 7 8 9 10 11 Pos Pts 2015 Yamaha ALG1 18 ALG2 17 CAT ARA1 ARA2 ALB 14 NAV1 8 NAV2 11 JER VAL1 12 VAL2 16 1st 175S100A10 (4,728 words) [view diff] exact match in snippet view article find links to article
interaction with p11. Some of these proteins include Nav1.8, TRPV5, TRPV6, TASK-1, and ASIC1a. Nav1.8 is a tetrodotoxin-resistant sodium channel that replacesHot plate test (1,002 words) [view diff] exact match in snippet view article find links to article
nociceptors and the spinal cord. Specific ion channel isoforms such as Nav1.7 and Nav1.8 sodium channels and Cav3.2 T-type calcium channels have distinct pro-nociceptiveMethylglyoxal (1,210 words) [view diff] exact match in snippet view article find links to article
Susanne K; Eberhardt, Mirjam; et al. (2012). "Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabeticProtoxin-I (1,797 words) [view diff] exact match in snippet view article find links to article
through interaction with the Nav1.8 channel. Protoxin-I has been found to potently bind to NaV1.2, NaV1.6, NaV1.7 and NaV1.8. The pore-forming α subunitErythromelalgia (6,120 words) [view diff] case mismatch in snippet view article find links to article
and sympathetic neurons is due to expression of NaV1.8 in the former. Consequently, expression of NaV1.8 channels in sympathetic neurons also expressingPhrixotoxin (692 words) [view diff] exact match in snippet view article find links to article
channel subtypes (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A, and Nav1.8/SCN10A) (Bosmans 2006) harv error: no target: CITEREFBosmans2006 (help)Miquel Pons (117 words) [view diff] no match in snippet view article find links to article
7 8 9 10 11 Pos Pts 2014 Inmotec JER 15 ARA1 11 ARA2 10 CAT Ret ALB 10 NAV1 8 NAV2 Ret ALG1 10 ALG2 Ret VAL 9 12th 39 2015 Inmotec ALG1 9 ALG2 30 CATPostherpetic neuralgia (2,910 words) [view diff] exact match in snippet view article find links to article
accumulation causes hyperexcitability, and downregulation of the TTX-resistant Nav1.8 (sensory neuron specific, SNS1) channel and upregulation of TTX-sensitiveFamilial episodic pain syndrome (597 words) [view diff] exact match in snippet view article find links to article
; Pierro, Tiziana; Lombardi, Raffaella (2012-11-20). "Gain-of-function Nav1.8 mutations in painful neuropathy". Proceedings of the National Academy ofProtoxin-II (849 words) [view diff] exact match in snippet view article find links to article
inhibits several human sodium channel subtypes, ranging from Nav1.1 up to Nav1.8. However, this toxin is, at least, 100-fold more potent against Nav1.7 thanTa3a (606 words) [view diff] exact match in snippet view article find links to article
Ta3a targets voltage-gated sodium channels such as Nav1.6, Nav1.7 and Nav1.8, which are involved in peripheral pain signaling. The half-maximal effectiveJingzhaotoxin (1,428 words) [view diff] exact match in snippet view article find links to article
on VGSC JZTX-V has a high affinity to the resting closed state of TTX-R (Nav1.8 Nav1.9) and TTX-S (Nav1.6, Nav1.7) VGSC in DRG neurons. It modifies the