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searching for NLRP3 73 found (103 total)

alternate case: nLRP3

Inflammasome (5,942 words) [view diff] exact match in snippet view article find links to article

metabolic syndrome and NLRP3, a subset type of inflammasome. Within their research on NLRP3, they were able to show that when NLRP3 is inhibited, an immunosuppressive
Sulfonylurea (1,896 words) [view diff] exact match in snippet view article find links to article
experimentally to inhibit interleukin 1 beta release from the NALP3 (or NLRP3) inflammasome. First-generation drugs include acetohexamide, carbutamide
Nigericin (305 words) [view diff] exact match in snippet view article find links to article
Its ability to induce K+ efflux also makes it a potent activator of the NLRP3 inflammasome Graven SN, Estrada-O S, Lardy HA (1966). "Alkali metal cation
NLRC4 (1,195 words) [view diff] exact match in snippet view article find links to article
transcriptional co-activator CIITA and the canonical inflammasome protein NLRP3. A truncated murine NLRC4 was the first member of this family whose crystal
Pattern recognition receptor (5,210 words) [view diff] exact match in snippet view article find links to article
(called NLRP1 to NLRP14). NLRP3 and NLRP4 are responsible for the inflammasome activation. NLRP3 can be activated and give rise to NLRP3 inflammasome by ATP
Cholesterol crystal (478 words) [view diff] exact match in snippet view article find links to article
Cholesterol crystals are believed to induce inflammation by activation of the NLRP3 inflammasome. In addition to being a source of inflammation, cholesterol
Neonatal-onset multisystem inflammatory disease (1,190 words) [view diff] exact match in snippet view article find links to article
syndromes. NOMID can result from a mutation in the CIAS1 gene (also known as NLRP3 gene), which helps control inflammation. Mutations in this gene also cause
Keratoendotheliitis fugax hereditaria (762 words) [view diff] exact match in snippet view article find links to article
mutation in cryopyrin (also known as NALP3) that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. In keratoendotheliitis fugax
Damage-associated molecular pattern (3,562 words) [view diff] exact match in snippet view article find links to article
re-epithelialization in AKI. Finally, DAMPs also promote renal fibrosis by inducing NLRP3, which also promotes TGF-β receptor signaling. Seong SY, Matzinger P (June
Caspase 1 (2,387 words) [view diff] exact match in snippet view article find links to article
Zhang C, Song JW, Huang HH, Fan X, Huang L, Deng JN, et al. (March 2021). "NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1-infected patients"
GSDMD (1,701 words) [view diff] exact match in snippet view article find links to article
the canonical pathway and is activated by canonical inflammasomes such as NLRP3 and NLRC4 inflammasomes, which are multi-protein complexes that are formed
NLRC3 (244 words) [view diff] exact match in snippet view article find links to article
cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly negative regulation of NIK/NF-kappaB signaling
Caspase (3,098 words) [view diff] exact match in snippet view article find links to article
Leucine Rich Repeat NLRP3 will sense an efflux of potassium ions from the cell. This cellular ion imbalance leads to oligomerisation of NLRP3 molecules to form
Shake it Up Australia Foundation (2,614 words) [view diff] exact match in snippet view article find links to article
specifically the microglia called NLRP3 inflammasome which is highly activated in patients with Parkinson's disease. The NLRP3 inflammasome reacts to synuclein
AIM2 (1,969 words) [view diff] exact match in snippet view article find links to article
Sharma M, de Alba E (January 2021). "Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes". International Journal of Molecular Sciences. 22
ZBP1 (897 words) [view diff] exact match in snippet view article find links to article
2016). "ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways". Science Immunology. 1
Caspase 12 (608 words) [view diff] exact match in snippet view article find links to article
endopeptidase activity involved in apoptotic signaling pathway Cellular component NLRP3 inflammasome complex AIM2 inflammasome complex IPAF inflammasome complex
Fibrosis (1,031 words) [view diff] exact match in snippet view article find links to article
against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of
Cold urticaria (2,377 words) [view diff] exact match in snippet view article find links to article
cryopyrin-associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NALP3 (aka NLRP3) gene at location 1q44. The effect of FCAS on the quality of life of patients
Inflammaging (2,733 words) [view diff] exact match in snippet view article find links to article
ISSN 0065-2598. PMID 27734407. Latz, Eicke; Duewell, Peter (2018-12-01). "NLRP3 inflammasome activation in inflammaging". Seminars in Immunology. Inflammaging
Vishva Dixit (3,436 words) [view diff] exact match in snippet view article find links to article
provided unequivocal genetic evidence by identifying the NOD-like receptors NLRP3 and NLRC4 as proximal components of inflammasomes responsible for caspase-1
TLR6 (1,072 words) [view diff] exact match in snippet view article find links to article
anatomical structure receptor complex Biological process positive regulation of NLRP3 inflammasome complex assembly immune system process positive regulation
Thioacetamide (497 words) [view diff] exact match in snippet view article find links to article
against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of
Mohammad Zahid Ashraf (964 words) [view diff] exact match in snippet view article find links to article
Tarun; Chatterjee, Tathagata; Prabhakar, Amit (2017-05-02). "Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia"
Anakinra (1,658 words) [view diff] exact match in snippet view article find links to article
2021). "Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release". The Journal of Experimental Medicine. 218
Muckle–Wells syndrome (543 words) [view diff] exact match in snippet view article find links to article
(painful joints) MWS occurs when a mutation in the CIAS1 gene, encoding for NLRP3, leads to increased activity of the protein cryopyrin. This protein is partly
Immunogenic cell death (2,052 words) [view diff] exact match in snippet view article find links to article
the cytosolic PRRs that are known to induce inflammasome formation are NLRP3, NLRP1, NLRC4, AIM2 and Pyrin. These proteins contain oligomerization NACHT
Tranilast (704 words) [view diff] exact match in snippet view article find links to article
Liang G, Zhang H, Jiang W, Zhou R (April 2018). "Tranilast directly targets NLRP3 to treat inflammasome-driven diseases". EMBO Molecular Medicine. 10 (4)
GBP5 (82 words) [view diff] exact match in snippet view article find links to article
involved in inflammatory response inflammatory response positive regulation of NLRP3 inflammasome complex assembly protein homotetramerization positive regulation
Luke O'Neill (professor) (1,177 words) [view diff] exact match in snippet view article
medicines. He has co-founded Inflazome with Matt Cooper which developed NLRP3 inhibitors and was acquired by Roche Ltd in 2020, and Sitryx with Houman
Serum amyloid A1 (4,237 words) [view diff] exact match in snippet view article find links to article
by SAA1 for a number of cellular functions including the activation of NLRP3 inflammasomes. SAA1 has been found to interact with outer membrane protein
MEFV (835 words) [view diff] exact match in snippet view article find links to article
protein 1 alpha production immune system process negative regulation of NLRP3 inflammasome complex assembly inflammatory response negative regulation
Cornus officinalis (1,341 words) [view diff] exact match in snippet view article find links to article
metalloproteinase-13 (MMP13), Caspase-1 and nod-like receptor protein-3 (NLRP3) expression in DMM mice and IL-1β-stimulated chondrocytes, and enhances
Mefenamic acid (1,660 words) [view diff] exact match in snippet view article find links to article
Watremez W, Fasolino V, et al. (August 2016). "Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models".
Familial Mediterranean fever (2,394 words) [view diff] exact match in snippet view article find links to article
Feigenbaum L, et al. (May 2011). "Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation
Caspase recruitment domain-containing protein 8 (566 words) [view diff] exact match in snippet view article find links to article
binding CARD domain binding identical protein binding Cellular component NLRP3 inflammasome complex nucleoplasm cytoplasm nucleus cytosol protein-containing
Sirius Red (193 words) [view diff] exact match in snippet view article find links to article
against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation". Naunyn-Schmiedeberg's Archives of
Vincristine (2,408 words) [view diff] exact match in snippet view article find links to article
2021). "Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release". The Journal of Experimental Medicine. 218
Bamboo charcoal (1,133 words) [view diff] exact match in snippet view article find links to article
October 2013). "Bamboo Vinegar Decreases Inflammatory Mediator Expression and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation
Giulio Maria Pasinetti (3,260 words) [view diff] exact match in snippet view article find links to article
(2021). "Discovery and characterization of small molecule inhibitors of NLRP3 and NLRC4 inflammasomes". Journal of Biological Chemistry. 296: 100597.
Silicon dioxide (6,316 words) [view diff] exact match in snippet view article find links to article
clinically relevant periods. Silica crystals inside the lungs can activate the NLRP3 inflammasome inside macrophages and dendritic cells and thereby result in
Crystallopathy (821 words) [view diff] exact match in snippet view article find links to article
for crystallopathies with treatments such as IL-1a and IL-1b antagonists, NLRP3-antagonists, or blockers of ferroptosis and necroptosis. For protein-based
FSTL1 (1,415 words) [view diff] exact match in snippet view article find links to article
Y, Vockley J, Hirsch R (May 2014). "Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages". European
PYCARD (1,320 words) [view diff] exact match in snippet view article find links to article
activity cysteine-type endopeptidase activity Cellular component cytoplasm NLRP3 inflammasome complex NLRP1 inflammasome complex AIM2 inflammasome complex
Dicer (3,163 words) [view diff] exact match in snippet view article find links to article
"DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88". Cell. 149 (4): 847–59. doi:10.1016/j.cell.2012
Protein kinase R (3,602 words) [view diff] exact match in snippet view article find links to article
regulation of osteoblast proliferation protein autophosphorylation regulation of NLRP3 inflammasome complex assembly peptidyl-tyrosine phosphorylation innate immune
Cardiolipin (3,390 words) [view diff] exact match in snippet view article find links to article
cytochrome c (cyt c) release, Caspase-8 activation, MOMP induction and NLRP3 inflammasome activation. During apoptosis, cyt c is released from the intermembrane
Depression and immune function (6,556 words) [view diff] exact match in snippet view article find links to article
depression is associated with increased inflammasome activation in general, the NLRP3 inflammasome complex has received the most attention in relation to major
Titanium dioxide (6,191 words) [view diff] case mismatch in snippet view article find links to article
(November 2010). "Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α
Kathryn Moore (685 words) [view diff] exact match in snippet view article find links to article
Sciences Peter Duewell; Hajime Kono; Katey Rayner; et al. (1 April 2010). "NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol
Cathepsin B (3,077 words) [view diff] exact match in snippet view article find links to article
Pfister HW, Fontana A, Hammerschmidt S, Koedel U (November 2011). "The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and
Candidalysin (1,010 words) [view diff] exact match in snippet view article find links to article
et al. (October 2018). "The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes". Nature Communications
Ionophore (4,137 words) [view diff] exact match in snippet view article find links to article
M.; Núñez, Gabriel (27 June 2013). "K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter". Immunity
CD36 (5,143 words) [view diff] exact match in snippet view article find links to article
kinase/NF-kappaB signaling response to stilbenoid positive regulation of NLRP3 inflammasome complex assembly low-density lipoprotein particle clearance
TLR4 (5,519 words) [view diff] exact match in snippet view article find links to article
positive regulation of stress-activated MAPK cascade positive regulation of NLRP3 inflammasome complex assembly positive regulation of interleukin-12 production
AMP-activated protein kinase (6,472 words) [view diff] exact match in snippet view article find links to article
silica causing silicosis, cholesterol crystals causing inflammation via NLRP3 inflammasome and rupture of atherosclerotic lesions, urate crystals associated
Gladstone Institutes (3,112 words) [view diff] exact match in snippet view article find links to article
Bo; Wang, Kun; Li, Jing; Zhou, Ming-Ju; Yang, Cui-Xian (2021-03-15). "NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1-infected patients"
PANoptosis (827 words) [view diff] exact match in snippet view article find links to article
(2016-08-05). "ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways". Science Immunology. 1
Bharathi Women's College (3,031 words) [view diff] exact match in snippet view article find links to article
high fat diet induced pancreatic inflammation and fibrosis in rats-Role of NLRP3 inflammosomes ICMR-SRF 2013-14 2,82,000 + Rs. 20,000 (Contingency) Completed
Clare Bryant (735 words) [view diff] exact match in snippet view article find links to article
(2014-05-06). "Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex". Proceedings of the National Academy
Postbiotic (1,356 words) [view diff] exact match in snippet view article find links to article
I.C., et al., Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice
Arglabin (1,298 words) [view diff] exact match in snippet view article find links to article
Monica Rubio (2015). "Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet". Circulation
T helper cell (7,447 words) [view diff] exact match in snippet view article find links to article
Bo; Wang, Kun; Li, Jing; Zhou, Ming-Ju; Yang, Cui-Xian (2021-03-15). "NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients"
Sirtuin 2 (3,647 words) [view diff] exact match in snippet view article find links to article
negative regulation of protein catabolic process negative regulation of NLRP3 inflammasome complex assembly negative regulation of oligodendrocyte progenitor
PELP-1 (3,891 words) [view diff] exact match in snippet view article find links to article
G; Wang, J; Thiruvaiyaru, D; Vadlamudi, R; Zhang, Q; Brann, D (2016). "NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and
Murine respirovirus (27,845 words) [view diff] exact match in snippet view article find links to article
Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly". Journal of Virology. 92 (19): e00842–18. doi:10
Carcinogenesis (13,401 words) [view diff] exact match in snippet view article find links to article
"Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome". The Journal of Biological Chemistry. 286 (44): 38703–13.
Reactive aldehyde species (1,335 words) [view diff] exact match in snippet view article find links to article
Antero; Kaarniranta, Kai (September 2012). "Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration
Jennifer Stow (1,669 words) [view diff] exact match in snippet view article find links to article
; Sweet, M.J.; Stow, J.L.; Schroder, K. (2016). "The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline
Bat virome (7,840 words) [view diff] exact match in snippet view article find links to article
Chia, Wan Ni; Mani, Shailendra; Wang, Loo Chien; et al. (2019). "Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir
Circulating free DNA (3,913 words) [view diff] exact match in snippet view article find links to article
Town T, Arditi M (March 2012). "Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis". Immunity. 36 (3): 401–14. doi:10.1016/j
Innate lymphoid cell (10,496 words) [view diff] exact match in snippet view article find links to article
(January 2014). "Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity". Nature
Genome-wide CRISPR-Cas9 knockout screens (6,102 words) [view diff] exact match in snippet view article find links to article
Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation". The Journal of Biological Chemistry. 291 (1):