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searching for NF-κB 85 found (1566 total)

alternate case: nF-κB

NEDD8 (2,832 words) [view diff] exact match in snippet view article find links to article

IκBα, and this inhibits NF-κB translocation to the nucleus. Pevonedistat, through its effects on NF-κB and a target of NF-κB (microRNA-155), prolonged
Morin (flavonol) (289 words) [view diff] exact match in snippet view article
response. Morin treatment significantly down-regulated expressions of BLT2, NF-κB, and Th2-cytokine (TNF-α, IL-1β, IL-4, IL-6, and IL-13) in lungs of murine
IL17RD (1,360 words) [view diff] exact match in snippet view article find links to article
TNF-activated NF-κB. Another study focusing on renal cells describes IL-17RD to associate with TNFR2, but not TNFR1, to augment NF-κB activation. The
IL17RB (728 words) [view diff] exact match in snippet view article find links to article
IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart
Pepstatin (409 words) [view diff] exact match in snippet view article find links to article
upon cells remain unclear. Pepstatin A suppresses receptor activator of NF-κB ligand (RANKL)–induced osteoclast differentiation. Pepstatin A suppresses
Anoikis (721 words) [view diff] exact match in snippet view article find links to article
dysregulation of the pathway network that controls transcription factor NF-κB. Apoptosis Metastasis Programmed cell death Frisch SM, Screaton RA (October
NKIRAS2 (275 words) [view diff] exact match in snippet view article find links to article
NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene. GRCh38: Ensembl release 89: ENSG00000168256 - Ensembl
BMS-345541 (71 words) [view diff] exact match in snippet view article find links to article
allosteric site-binding inhibitor with a primary target of IKK-2 and blocks the NF-κB-dependent transcription in mice. It has no approvals for human/medical use
SETD6 (741 words) [view diff] exact match in snippet view article find links to article
gene. SETD6 monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). RelA mono-methylation at lysine 310 (RelAK310me1) leads to the constitutive
Swietenia macrophylla (1,503 words) [view diff] exact match in snippet view article find links to article
(IL-6). SMEAF inhibited nuclear translocation of nuclear factor-kappa B (NF-κB) via the attenuation of IκBα phosphorylation. Moreover, SMEAF markedly suppressed
TICAM1 (616 words) [view diff] exact match in snippet view article find links to article
NF-κB, indicating the use of the RIP1 gene in downstream TICAM1 activation, in contrast to other TLRs that use IRAK protein for the activation of NF-κB
Embelin (475 words) [view diff] no match in snippet view article find links to article
stress, inflammatory cascade (inflammatory cytokines release), and MAPK/NFκB signaling pathway in paraquat‐intoxicated rats Embelin and embelin derivatives
Ranpirnase (1,234 words) [view diff] exact match in snippet view article find links to article
siRNA molecules; to cleavage of transfer RNA; and to interference with the NF-κB pathway. Currently (as of March 2020) Ranpirnase is in clinical trials as
Nobiletin (385 words) [view diff] exact match in snippet view article find links to article
described. Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer[5]. Nagase H, Yamakuni T, Matsuzaki
Toll-like receptor 9 (2,551 words) [view diff] exact match in snippet view article find links to article
work through MyD88, an adaptor molecule that increases the expression of NF-κB. However autoimmune thyroid diseases also increase sensitivity of MyD88
MARCH2 (733 words) [view diff] exact match in snippet view article find links to article
turnover of membrane proteins. MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections. Like the
NLRP11 (1,271 words) [view diff] exact match in snippet view article find links to article
in human cells. NALPs family controls cytokines, inflammatory responses, NF-κB activation, and likely cell death and survival. This gene encodes a protein
Soumen Basak (1,091 words) [view diff] exact match in snippet view article find links to article
Roy, P; Basak, S (23 April 2015). "Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection"
Dmitry Gabrilovich (464 words) [view diff] exact match in snippet view article find links to article
linked to a number of signaling pathways associated with cancer, including NF-κB, Jak-STAT, Notch, Wnt, and Rb, among others. His research has found that
GPR97 (850 words) [view diff] exact match in snippet view article find links to article
monophosphate (cAMP). GPR97 actives cAMP response element-binding protein (CREB), NF-κB, and small GTPases to regulate cellular functions. Systemic steroid exposure
Antileukotriene (1,070 words) [view diff] exact match in snippet view article find links to article
the NF-κB inflammation factor, conducted by Bork et al. (1999), in which hyperforin provided a potent inhibition of TNFα-induced activation of NF-κB [58]
TLR4-IN-C34 (302 words) [view diff] exact match in snippet view article find links to article
Wang H, Wang C, et al. (June 2019). "Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine
P38 mitogen-activated protein kinases (1,385 words) [view diff] exact match in snippet view article find links to article
p38, and thereby cause excessively high activity of transcription factor NF-κB. This transcription factor is normally regulated from intracellular pathways
TTRAP (1,484 words) [view diff] exact match in snippet view article find links to article
module, resulting in differential regulation of TGF-β activated p38 and NF-κB responses. Modulation of cellular TTRAP level affects cell viability in
Arachidonate 5-lipoxygenase inhibitor (1,291 words) [view diff] exact match in snippet view article find links to article
the NF-κB inflammation factor, conducted by Bork et al. (1999), in which hyperforin provided a potent inhibition of TNFα-induced activation of NF-κB [58]
Jules A. Hoffmann (1,360 words) [view diff] exact match in snippet view article find links to article
antimicrobial peptides contained DNA sequences similar to the binding elements for NF-κB in mammalian DNA. Dorsal gene, critical in dorso-ventral patterning in the
Mir-618 microRNA precursor family (383 words) [view diff] exact match in snippet view article find links to article
cells. This further influences several genes involved in regulation of the NF-κB-related pathway network. MicroRNA Cicatiello L, Mutarelli M, Grober OM,
Gliotoxin (3,112 words) [view diff] exact match in snippet view article find links to article
different enzymes, including nuclear factor-κB (NF-κB), NADPH oxidase, and glutaredoxin. The inhibition of NF-κB leads prevents cytokine release and induction
RNF25 (413 words) [view diff] exact match in snippet view article find links to article
been shown to interact with Rela, the p65 subunit of NF-kappaB (NF-κB), and modulate NF-κB-mediated transcription activity. The mouse protein also binds
Fascin (1,556 words) [view diff] exact match in snippet view article find links to article
NF-κB. This results to limited fascin expression and allows tissue to rebuild epithelial barriers. In cancer, instead, TGF-β does not restrict NF-κB activity
Sodium salicylate (411 words) [view diff] exact match in snippet view article find links to article
Susana Langa; Steven J. Tucker; David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction
Caspase-8 deficiency (822 words) [view diff] exact match in snippet view article find links to article
essential for the induction of the transcription factor “nuclear factor κB” (NF-κB) after stimulation through antigen receptors, Fc receptors, or Toll-like
Uncaria tomentosa (895 words) [view diff] exact match in snippet view article find links to article
MJ (December 1998). "Antiinflammatory actions of cat's claw: the role of NF-κB". Alimentary Pharmacology & Therapeutics. 12 (12): 1279–1289. doi:10.1046/j
MATH domain (656 words) [view diff] exact match in snippet view article find links to article
downstream protein kinases and, ultimately, transcription factors of the NF-κB and AP-1 family. The TRAF proteins are composed of 3 structural domains:
Anelloviridae (738 words) [view diff] exact match in snippet view article find links to article
Wu, Z., 2007. Torque teno virus (SANBAN Isolate) ORF2 protein suppresses NF-κB pathways via interaction with IκB kinases. Journal of virology, 81(21),
TNIP2 (783 words) [view diff] exact match in snippet view article find links to article
TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting
MAP3K7 (1,695 words) [view diff] exact match in snippet view article find links to article
extracellular stimuli. TAK1 regulates cell survival not solely through NF-κB but also through NF-κB-independent pathways such as oxidative stress and receptor-interacting
Photoaging (2,292 words) [view diff] exact match in snippet view article find links to article
UV radiation activates the transcription factor, NF-κB, which is the first step in inflammation. NF-κB activation results in the increase of proinflammatory
KMUP-1 (76 words) [view diff] exact match in snippet view article find links to article
osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and calcium/calcineurin/NFATc1 pathways". PLOS ONE. 8 (7): e69468. Bibcode:2013PLoSO
IFNG-AS1 (gene) (502 words) [view diff] exact match in snippet view article
(HS) between Ifng and IFNG-AS1 which induce transcription factors such as NF-κB and ETS proto-oncogene 1 (Ets-1). T-bet could control chromatin remodeling
Transforming growth factor beta (8,680 words) [view diff] exact match in snippet view article find links to article
cell proliferation. It is also known to induce NF-κB inhibitor IKBa, inhibiting NF-κB activation. NF-κB is a transcription factor that regulates the production
White spot syndrome (1,899 words) [view diff] exact match in snippet view article find links to article
similarity to host protein Tube and can function like Tube by activating the NF-κB pathway. Viral replication is nuclear; DNA-templated transcription is its
Garry Nolan (2,019 words) [view diff] exact match in snippet view article find links to article
the 293T-based rapid retroviral production system and the cloning of the NF-κB p65/ RelA DNA regulatory factor. His areas of research include autoimmunity
EHMT1 (1,596 words) [view diff] exact match in snippet view article find links to article
methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling". Nature
Lymphocytosis (533 words) [view diff] exact match in snippet view article find links to article
"Impaired Control of Epstein-Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease". Frontiers in Immunology. 9: 198. doi:10.3389/fimmu
Osteoprotegerin (3,686 words) [view diff] exact match in snippet view article find links to article
progenitor cells RANK-RANKL binding activates the nuclear factor kappa B (NF-κB) pathway resulting in the upregulation of the transcription factor nuclear
Joyoti Basu (1,517 words) [view diff] exact match in snippet view article find links to article
Joyoti; Kundu, Manikuntala (15 August 2015). "Retraction: TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered
Patrick A. Baeuerle (888 words) [view diff] exact match in snippet view article find links to article
"Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor". Cell. 53 (2): 211–217. doi:10.1016/0092-8674(88)90382-0
Phlorofucofuroeckol A (263 words) [view diff] exact match in snippet view article find links to article
LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK". Toxicology in Vitro. 25 (8): 1789–95. doi:10.1016/j
Felix Armin Randow (699 words) [view diff] exact match in snippet view article find links to article
ubiquitin chains directly onto cytosol-invading bacteria, thereby activating NF-κB and autophagy, revealed another novel concept of cell-autonomous immunity
Cornus officinalis (1,353 words) [view diff] exact match in snippet view article find links to article
apoptosis. It also slows OA progression by inhibiting nuclear factor-κB (NF-κB) signaling. A randomized, double-blinded, placebo-controlled study found
Efonidipine (1,414 words) [view diff] exact match in snippet view article find links to article
hypertension induced renal damage. Efonidipine prevents Rho-kinase and NF-κB induced renal parenchymal fibrosis and provides long term renal protection
TRIM52 (207 words) [view diff] exact match in snippet view article find links to article
proliferation, migration, and regulation of colon cancer cells associated with the NF-κB signaling pathway". Journal of Gastrointestinal Oncology. 13 (3). AME Publishing
Tetrahydrocoptisine (81 words) [view diff] exact match in snippet view article find links to article
lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathway". European Journal of Pharmacology. 715 (1–3):
Mir-23 microRNA precursor family (949 words) [view diff] exact match in snippet view article find links to article
Bettignies C, Tempé D, Lecellier CH, Villalba M (September 2012). "The NF-κB member p65 controls glutamine metabolism through miR-23a". The International
Bunyaviridae nonstructural S proteins (852 words) [view diff] exact match in snippet view article find links to article
to interfere with TBK1 which is needed in the activation of both IRF and NF-κB pathways. UUKV is a non-human pathogen that still creates a NSs protein
CD8 (699 words) [view diff] exact match in snippet view article find links to article
phosphorylation eventually leading to activation of transcription factors like NFAT, NF-κB, and AP-1 which affect the expression of certain genes. Gao G, Jakobsen
Sodium hypochlorite (5,753 words) [view diff] exact match in snippet view article find links to article
activated B cells (NF-κB) is known to play a critical role in inflammation, aging, and response to radiation. The researchers found that if NF-κB activity was
Flavokavain B (148 words) [view diff] exact match in snippet view article find links to article
root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732) Flavokawain
Picornain 3C (2,412 words) [view diff] exact match in snippet view article find links to article
HAV. Hepatitis A 3C protease cleaves NEMO at the Q304 residue; NEMO is a NF-κB essential modulator responsible for activation of interferon (IFN) antiviral
ROSAH syndrome (696 words) [view diff] exact match in snippet view article find links to article
with mutated ALPK1 constructs have shown immune activation with increased NF-κB signaling, STAT1 phosphorylation and interferon gene expression signature
Carcinogenic bacteria (2,434 words) [view diff] exact match in snippet view article find links to article
many human cancers . This leads to the activation of the pro-inflammatory NF-κB and β-catenin pathways as well as increased gastric cell proliferation.
PBRM1 (1,300 words) [view diff] exact match in snippet view article find links to article
been shown to potentiate HIF1α signaling and activate the pro-tumorigenic NF-κB pathway. Genetic loss of PBRM1 is thought to underlie the early initiation
Epstein–Barr virus latent membrane protein 1 (509 words) [view diff] exact match in snippet view article find links to article
PMC 3118346. PMID 21592361. Ersing, I; Bernhardt, K; Gewurz, BE (Jun 21, 2013). "NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein
Immune disorder (745 words) [view diff] exact match in snippet view article find links to article
bacteria and opportunistic infections. Leukocyte adhesion deficiency (LAD) NF-κB Essential Modifier (NEMO) Mutations Selective immunoglobulin A deficiency:
Vitisin A (stilbenoid) (252 words) [view diff] exact match in snippet view article
"Vitisin a suppresses LPS-induced NO production by inhibiting ERK, p38, and NF-κB activation in RAW 264.7 cells". International Immunopharmacology. 9 (3):
Heat shock protein 90kDa alpha (cytosolic), member A1 (8,175 words) [view diff] exact match in snippet view article
expression through STAT5. NF-κB or RELA also induces HSP90AA1 expression possibly explaining the pro-survival ability of NF-κB-driven transcription. Conversely
Prenylflavonoid (1,010 words) [view diff] exact match in snippet view article find links to article
in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3". Evidence-Based Complementary and Alternative Medicine. 2011:
WNT16 (645 words) [view diff] exact match in snippet view article find links to article
regulated by nuclear factor of κ light polypeptide gene enhancer in B cells 1 (NF-κB) after DNA damage, as can occur to normal cells during radiation or chemotherapy
Bacterial effector protein (3,130 words) [view diff] exact match in snippet view article find links to article
Tran (16 December 2010). "NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA". PLOS Pathogens. 6 (12): e1001231. doi:10
Prenylflavonoid (1,010 words) [view diff] exact match in snippet view article find links to article
in A549 Cells via Blocking PI3K-Mediated Transcriptional Activation of NF-κB and IRF3". Evidence-Based Complementary and Alternative Medicine. 2011:
Porcine reproductive and respiratory syndrome virus 2 (2,788 words) [view diff] exact match in snippet view article find links to article
signaling cascade. When researchers knocked out DHX36, the activation of NF-κB signaling by PRSSV and nucleocapsid (N) protein was inhibited. Because of
Tetrandrine (761 words) [view diff] exact match in snippet view article find links to article
protects mice from concanavalin A-induced hepatitis through inhibiting NF-κB activation". Immunology Letters. 121 (2): 127–133. doi:10.1016/j.imlet.2008
Marginal zone (1,161 words) [view diff] exact match in snippet view article find links to article
marginal zone B cells and accelerated loss of follicular dendritic cells in NF-κB p50-deficient mice". BMC Immunology. 6: 8. doi:10.1186/1471-2172-6-8. PMC 1087843
LRRC26 (243 words) [view diff] exact match in snippet view article find links to article
Becker KG, Bera TK, Pastan I (March 2012). "CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis". Oncogene. 31 (13):
Crohns MAP Vaccine (296 words) [view diff] exact match in snippet view article find links to article
Immunomodulatory Therapeutic Response in Crohn's Disease through Downregulation of NF-κB Activation in the Absence of MAP Detection". Biomedicines. 8 (11): 513.
Toll-like receptor 10 (833 words) [view diff] exact match in snippet view article find links to article
not yet known but activation of the receptor has been shown to suppress NF-κB, MAP kinase and Akt signaling events stimulated by TLR and CD40 ligands
Nostoc commune (591 words) [view diff] exact match in snippet view article find links to article
algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes". Biochimica et Biophysica Acta (BBA)
Farnesyltransferase inhibitor (1,079 words) [view diff] exact match in snippet view article find links to article
immunosuppressive mycotoxin. Displays a capacity to induce apoptosis and inhibit NF-κB activation. 67-99-2 α-hydroxy Farnesyl Phosphonic Acid sc-205200 α-hydroxy
NLRC5 (468 words) [view diff] exact match in snippet view article find links to article
Cui J, Zhu L, Xia X, et al. (April 2010). "NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity". Cell.
O-GlcNAc (12,376 words) [view diff] exact match in snippet view article find links to article
associated with NF-κB activation such as p300-mediated K310 acetylation and IKK-mediated S536 phosphorylation. These results suggested that NF-κB is constitutively
Toll-like receptor 8 (1,091 words) [view diff] exact match in snippet view article find links to article
protein 88 (MyD88) and leads to activation of the transcription factor NF-κB and an antiviral response that leads to proinflammatory cytokine synthesis
Velutin (196 words) [view diff] exact match in snippet view article find links to article
agent: Blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway". The Journal of Nutritional Biochemistry. 23
Ecklonia stolonifera (604 words) [view diff] exact match in snippet view article find links to article
LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK". Toxicology in Vitro. 25 (8): 1789–95. doi:10.1016/j
Phellibaumin (383 words) [view diff] exact match in snippet view article find links to article
Yuan, Hui-Qing; Lou, Hong-Xiang (2011-06-01). "Phenolic compounds with NF-κB inhibitory effects from the fungus Phellinus baumii". Bioorganic & Medicinal