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searching for Mutational signatures 18 found (31 total)

COSMIC cancer database (979 words) [view diff] exact match in snippet view article find links to article

identification of 103 somatic DNA rearrangements. COSMIC also catalogues mutational signatures in human cancer through the COSMIC Signatures group, which represents

Serena Nik-Zainal (848 words) [view diff] exact match in snippet view article find links to article

patterns of cancer. She showed that it was possible to identify mutational signatures using downstream analysis, and that algorithms could be used to

Avesthagen (1,762 words) [view diff] exact match in snippet view article find links to article

(AGENOME-ZPMCG V 1.0). Dynamic Methylome Modification associated with mutational signatures in ageing and etiology of disease In 2020, Avesthagen released a

Oncogenomics (7,684 words) [view diff] exact match in snippet view article find links to article

matrix. This matrix can be further decomposed into components (mutational signatures) which ideally should describe individual mutagenic factors. Several

Jórunn Erla Eyfjörð (2,034 words) [view diff] exact match in snippet view article find links to article

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. Nat Med. (2017) Apr;23(4):517-525. doi: 10.1038/nm.4292. Epub 2017

Kelly A. Frazer (772 words) [view diff] exact match in snippet view article find links to article

GWAS signals and has contributed to a greater understanding of mutational signatures in cancer. "Home - Division of Genome Information Sciences - UC

Aristolochia (3,052 words) [view diff] case mismatch in snippet view article find links to article

Steven G.; Tan, Patrick; Teh, Bin Tean (7 August 2013). "Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool". Science

Cancer Genome Project (1,664 words) [view diff] exact match in snippet view article find links to article

then utilized mathematical methods to help determine the unique mutational signatures of the underlying processes leading to the evolution from healthy

Mutagenesis (4,335 words) [view diff] case mismatch in snippet view article find links to article

Tse, Julie Y.; Decker, Brennan (23 March 2022). "Prevalence of UV Mutational Signatures Among Cutaneous Primary Tumors". JAMA Network Open. 5 (3): e223833

Aristolochic acid (2,601 words) [view diff] case mismatch in snippet view article find links to article

Guan, P.; Weng, W.-H.; Siew, E. Y.; Liu, Y. (2013). "Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool". Science

Ribonucleoprotein Networks Analyzed by Mutational Profiling (1,854 words) [view diff] exact match in snippet view article find links to article

un-crosslinked (UV only) mutation frequency. Using differential mutational signatures, RNP-MaP sites are identified based on universal normalization factors

DNA polymerase (7,090 words) [view diff] exact match in snippet view article find links to article

cross-link where it was shown on the basis of the difference in the mutational signatures of the two polymerases, that pol IV and pol V compete for TLS of

Merkel-cell carcinoma (5,542 words) [view diff] exact match in snippet view article find links to article

these tumors tend to have much higher mutational burdens with mutational signatures characteristic of UV damage. Genes frequently mutated in MCV-negative

Skin cancer (6,508 words) [view diff] case mismatch in snippet view article find links to article

Fleischmann Z, Tse JY, Decker B (March 2022). "Prevalence of UV Mutational Signatures Among Cutaneous Primary Tumors". JAMA Network Open. 5 (3): e223833

Cancer (20,066 words) [view diff] exact match in snippet view article find links to article

cancer to develop in an individual can be identified by analyzing mutational signatures from genomic sequencing of tumor DNA. For example, this can reveal

Royal Medal (4,176 words) [view diff] exact match in snippet view article find links to article

genomics, the discovery of cancer genes and the identification of mutational signatures, which have transformed our understanding of cancer and somatic

Tumour heterogeneity (6,937 words) [view diff] exact match in snippet view article find links to article

context-dependent mutational profiles. It can be explored by COSMIC mutational signatures or MutaGene. Tumour cells can also show heterogeneity between their

April–June 2020 in science (28,437 words) [view diff] exact match in snippet view article find links to article

Campbell, Peter J.; Gartner, Anton; Gerstung, Moritz (1 May 2020). "Mutational signatures are jointly shaped by DNA damage and repair". Nature Communications