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searching for Loss of heterozygosity 108 found (165 total)

RecLOH (417 words) [view diff] case mismatch in snippet view article find links to article

is a term in genetics that is an abbreviation for "Recombinant Loss of Heterozygosity". This is a type of mutation which occurs with DNA by recombination

Somatic mutation and recombination tests (1,742 words) [view diff] exact match in snippet view article find links to article

attractive in vivo model for human research. The tests identify loss of heterozygosity for the specified genetic markers in heterozygous or trans-heterozygous

WFDC1 (569 words) [view diff] exact match in snippet view article find links to article

inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers

Tet methylcytosine dioxygenase 2 (2,656 words) [view diff] exact match in snippet view article find links to article

in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies. TET2 encodes

DBC1 (856 words) [view diff] exact match in snippet view article find links to article

chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5'

Hyperinsulinemic hypoglycemia (1,114 words) [view diff] exact match in snippet view article find links to article

Paternal SUR1 mutation with clonal loss of heterozygosity of 11p15 Paternal Kir6.2 mutation with clonal loss of heterozygosity of 11p15 Diffuse hyperinsulinism

Founder effect (4,289 words) [view diff] exact match in snippet view article find links to article

makes the colony more vulnerable to extinction. The per generation loss of heterozygosity can be calculated as Δ h = − 1 / 2 N {\displaystyle \Delta {h}=-1/2N}

CBFA2T3 (1,059 words) [view diff] exact match in snippet view article find links to article

a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3". Cancer Res. 62 (16): 4599–604. PMID 12183414

CDH3 (gene) (1,422 words) [view diff] exact match in snippet view article

in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression

MXI1 (1,354 words) [view diff] exact match in snippet view article find links to article

repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas". Hum. Genet. 95 (6): 709–11

Mixed tumor (474 words) [view diff] exact match in snippet view article find links to article

(2006). "Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes". Modern Pathology. 19 (3): 350–355. doi:10

PINX1 (2,576 words) [view diff] exact match in snippet view article find links to article

prognostic factors and presence of lymph node metastasis Gastric Loss of heterozygosity of PINX1 gene more common in lymph node metastasis and higher TNM

Mir-22 (791 words) [view diff] exact match in snippet view article find links to article

miR-22 is found on the short arm of chromosome 17, in a minimal loss of heterozygosity region. It is highly conserved across many vertebrate species, including

VE-cadherin (2,113 words) [view diff] exact match in snippet view article find links to article

in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent

FBXO31 (626 words) [view diff] exact match in snippet view article find links to article

candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various solid tumors, is responsible for promoting MDM2 degradation

CDH8 (588 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–471. doi:10.1006/geno.1998.5281. PMID 9615235

MTMR9 (640 words) [view diff] exact match in snippet view article find links to article

"Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23". Genomics. 60 (1): 1–11. doi:10.1006/geno

Insulin-like growth factor 2 receptor (1,664 words) [view diff] exact match in snippet view article find links to article

"M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity". Nat. Genet. 11 (4): 447–9. doi:10.1038/ng1295-447. PMID 7493029

CDH15 (774 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235

Oligodendroglioma (2,938 words) [view diff] exact match in snippet view article find links to article

of 39 (69%) cases; there was no significant difference in 1p/19q loss of heterozygosity status between low-grade and anaplastic oligodendroglioma. 1p/19q

CDH12 (647 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235

CDH6 (762 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235

FAT1 (2,060 words) [view diff] exact match in snippet view article find links to article

as putative tumour suppressor or oncogene in different contexts. Loss of heterozygosity for FAT1 has been reported in primary oral carcinomas and astrocytic

CDH17 (780 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235

CDH11 (1,192 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235

Wilms' tumor (2,957 words) [view diff] no match in snippet view article find links to article

Early removal tends to promote positive outcomes. Tumor-specific loss-of-heterozygosity (LOH) for chromosomes 1p and 16q identifies a subset of Wilms' tumor

Laysan finch (645 words) [view diff] exact match in snippet view article find links to article

species at increased risk of extinction. The birds also suffered a loss of heterozygosity following founding events on other islands which may have caused

Jansen's metaphyseal chondrodysplasia (871 words) [view diff] case mismatch in snippet view article find links to article

1056/nejm199609053351004. ISSN 0028-4793. Szabo, E. (2002-08-01). "Loss of Heterozygosity in Parathyroid Glands of Familial Hypercalcemia with Hypercalciuria

AIM1 (498 words) [view diff] exact match in snippet view article find links to article

Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma"

Activin type 2 receptors (583 words) [view diff] exact match in snippet view article find links to article

Sterian A, Shibata D, Abraham JM, Meltzer SJ (December 2003). "Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal

ING2 (960 words) [view diff] exact match in snippet view article find links to article

Sirchia SM, Porta G, Rossella F, Grati FR, Simoni G (Apr 2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence

Surfactant protein C (1,281 words) [view diff] exact match in snippet view article find links to article

characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas". Genomics. 24 (3): 597–600. doi:10.1006/geno

Malignant peripheral nerve sheath tumor (1,111 words) [view diff] exact match in snippet view article find links to article

cause of the disease. Evidence supporting this hypothesis includes loss of heterozygosity on the 17p chromosome. The p53 (a tumor suppressor gene in the normal

EXT1 (951 words) [view diff] exact match in snippet view article find links to article

Cleton-Jansen AM, Wuyts W, et al. (1999). "EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas"

ING2 (960 words) [view diff] exact match in snippet view article find links to article

Sirchia SM, Porta G, Rossella F, Grati FR, Simoni G (Apr 2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence

THP-1 cell line (850 words) [view diff] exact match in snippet view article find links to article

type can change depending on the reference biorepository, due to loss of heterozygosity in multiple chromosomal regions, as THP-1 from the American Type

LZTS1 (546 words) [view diff] exact match in snippet view article find links to article

Tanzawa H (2004). "Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas". Int. J. Oncol. 23 (2): 297–302

Cell adhesion molecule 1 (1,186 words) [view diff] exact match in snippet view article find links to article

Allinen M, Peri L, Kujala S, et al. (2002). "Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter

Mir-562 microRNA precursor family (142 words) [view diff] exact match in snippet view article find links to article

Grundy P, Dome J, Huff V, Jones C, Aldred MA (October 2009). "Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562". Clinical

PTENP1 (571 words) [view diff] exact match in snippet view article find links to article

(December 2001). "Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease". The Journal of Investigative

Homeobox protein CDX-1 (1,147 words) [view diff] exact match in snippet view article find links to article

expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines". Proceedings of the National Academy

CUX1 (4,649 words) [view diff] no match in snippet view article find links to article

consequence of activating mutations in either KRAS, HRAS, BRAF or EGFR. Loss-of-heterozygosity (LOH) of the 7q22.1 chromosomal region, where CUX1 resides, was

ST7 (911 words) [view diff] exact match in snippet view article find links to article

JC, Thompson JC, Troncoso P, Kagan J, Conti CJ (December 1994). "Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor

Extatosoma tiaratum (1,374 words) [view diff] exact match in snippet view article find links to article

of haploid nuclei from the same individual meiosis resulting in loss of heterozygosity in the offspring. The outside material of E. tiaratum eggs consists

Lymphangioleiomyomatosis (11,094 words) [view diff] exact match in snippet view article find links to article

containing the wild-type copy of the TSC2 gene; this is referred to as loss of heterozygosity or LOH. LOH can be detected in microdissected LAM cells, in angiomyolipomas

FOXM1 (1,471 words) [view diff] exact match in snippet view article find links to article

keratinocytes can directly induce genomic instability in the form of loss of heterozygosity (LOH) and copy number aberrations. FOXM1 overexpression is involved

Michael Lynch (geneticist) (1,235 words) [view diff] exact match in snippet view article

extinct. It is hypothesized that this rapid extinction is caused by a loss of heterozygosity caused by asexual reproduction as well as gene conversion exposing

RCBTB2 (516 words) [view diff] exact match in snippet view article find links to article

for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer. 99

RAD54B (815 words) [view diff] exact match in snippet view article find links to article

Bryś M, Nowacka-Zawisza M, Romanowicz-Makowska H, et al. (2007). "Loss of heterozygosity in the RAD54B region is not predictive for breast carcinomas". Pol

PLAGL1 (965 words) [view diff] exact match in snippet view article find links to article

Lee C, Hamilton TC, Abdollahi A (2004). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55

DLC1 (3,165 words) [view diff] exact match in snippet view article find links to article

chromosome 8 (8p21.3-22), within a region that frequently undergoes loss of heterozygosity by either genomic deletion or epigenetic silencing mechanisms in

Mir-16 microRNA precursor family (2,695 words) [view diff] exact match in snippet view article find links to article

2098. PMID 11264177. Dong JT, Boyd JC, Frierson HF Jr (2001). "Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer". Prostate

SAFB (1,309 words) [view diff] exact match in snippet view article find links to article

Wong H, Lee AV, Osborne CK, O'Connell P (2001). "High rates of loss of heterozygosity on chromosome 19p13 in human breast cancer". Br. J. Cancer. 84 (4):

AXIN2 (1,422 words) [view diff] exact match in snippet view article find links to article

gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in

Lobular carcinoma in situ (2,411 words) [view diff] exact match in snippet view article find links to article

testing. LCIS often have the same genetic alterations (such as loss of heterozygosity on chromosome 16q, the locus for the e-cadherin gene) as the adjacent

Anne Rosenberg (2,430 words) [view diff] exact match in snippet view article find links to article

behavior of malignancies. Croce and Rosenberg reported there was a loss of heterozygosity at 11q22-q23 in breast tumors. Collaborations with Croce were focused

Thrombospondin-2 (1,050 words) [view diff] exact match in snippet view article find links to article

Nishimine M, Ishida E, Shimada K, Kirita T, Konishi N (Jun 2003). "Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression

MCC (gene) (753 words) [view diff] exact match in snippet view article

PMID 1846539. Curtis LJ, Bubb VJ, Gledhill S, et al. (1994). "Loss of heterozygosity of MCC is not associated with mutation of the retained allele in

Mir-26 microRNA precursor family (3,054 words) [view diff] exact match in snippet view article find links to article

glioma model both enhances de novo tumor formation and precludes loss of heterozygosity and the PTEN locus. Burkitt lymphoma miR-26a plays a role as a potential

Mitotic recombination (1,499 words) [view diff] case mismatch in snippet view article find links to article

Burlington: Jones & Bartlett. Tischfield, Jay A. (November 1997). "Loss of Heterozygosity, or: How I learned to Stop Worrying and Love Mitotic Recombination"

Electric ant (2,191 words) [view diff] exact match in snippet view article find links to article

would result from random fusion of meiotic products leading to loss of heterozygosity. In general, parthenogenesis appears to be favored in recently disturbed

SPRED1 (1,498 words) [view diff] exact match in snippet view article find links to article

one mutated allele (no somatic SPRED1 single-point mutation or loss of heterozygosity was found). The M4/M5 phenotype of AML are most closely associated

Golden trout (2,021 words) [view diff] exact match in snippet view article find links to article

periods create a significant risk of inbreeding depression, and loss of heterozygosity and genetic variance. Oncorhynchus mykiss gilberti—Kern River rainbow

BCL10 (1,813 words) [view diff] exact match in snippet view article find links to article

PMID 11960389. Lee WC, Balsara B, Liu Z, Jhanwar SC, Testa JR (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted

Chromosomal crossover (3,727 words) [view diff] exact match in snippet view article find links to article

It can also happen during mitotic division, which may result in loss of heterozygosity. Crossing over is important for the normal segregation of chromosomes

CPVL (1,435 words) [view diff] exact match in snippet view article find links to article

PMID 19467448. Grundy RG, Pritchard J, Scambler P, Cowell JK (July 1998). "Loss of heterozygosity for the short arm of chromosome 7 in sporadic Wilms tumour". Oncogene

2,6-Diaminopurine (1,394 words) [view diff] exact match in snippet view article find links to article

Tischfield, JA (20 June 2000). "Chromosome instability contributes to loss of heterozygosity in mice lacking p53". Proceedings of the National Academy of Sciences

Cadherin-2 (3,399 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235

Fibrocystic breast changes (2,573 words) [view diff] exact match in snippet view article find links to article

karyotypic changes such as modified expression of hormone receptors and loss of heterozygosity. Several variants of fibrocystic breast changes may be distinguished

Band 4.1-like protein 3 (1,180 words) [view diff] exact match in snippet view article find links to article

Greenberg ER, Titus-Ernstoff L, Newsham IF (Jul 2004). "Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence

Speyeria zerene hippolyta (1,485 words) [view diff] exact match in snippet view article find links to article

The founding events of isolated small populations may cause a loss of heterozygosity over generations and an accumulation of deleterious recessive alleles

Embryonal rhabdomyosarcoma (3,763 words) [view diff] exact match in snippet view article find links to article

in chromosomes 10 and 15. Another common genomic alteration is loss of heterozygosity at chromosome 11p, the short arm of chromosome 11. It is believed

T-cadherin (2,752 words) [view diff] exact match in snippet view article find links to article

cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–471. doi:10.1006/geno.1998.5281. PMID 9615235

Population structure (genetics) (3,423 words) [view diff] exact match in snippet view article

A population bottleneck can result in a loss of heterozygosity. In this hypothetical population, an allele has become fixed after the population repeatedly

SAP30 (1,841 words) [view diff] exact match in snippet view article find links to article

Sirchia SM, Porta G, Rossella F, Grati FR, Simoni G (April 2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence

Glutathione peroxidase 1 (2,833 words) [view diff] exact match in snippet view article find links to article

Schmidt L, Ingram DT, Gnarra J, Johnson B, Cowan KH (Dec 1994). "Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer"

Immature teratoma (2,724 words) [view diff] exact match in snippet view article find links to article

failures, leading to a tumor genome with high levels of copy neutral loss of heterozygosity. Though several studies have shown that size and stage of the primary

Plakoglobin (4,698 words) [view diff] exact match in snippet view article find links to article

plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers". Proceedings of the National Academy

MEN1 (2,664 words) [view diff] exact match in snippet view article find links to article

These familial MEN-1 and sporadic tumors may arise either due to loss of heterozygosity or the chromosome region 11q13 where MEN1 is located, or due to

PI3K/AKT/mTOR pathway (4,322 words) [view diff] exact match in snippet view article find links to article

Medina S, Chopin D, Thiery JP, Radvanyi F (June 1997). "Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas

RAD54L (1,444 words) [view diff] exact match in snippet view article find links to article

of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors". Cancer Research. 57 (12): 2378–2383. PMID 9192813

DIRAS3 (gene) (1,750 words) [view diff] exact match in snippet view article

monoallelically) and mapped specifically to 1p31, which is a common site for loss of heterozygosity (LOH). This locus on chromosome 1 is the most frequent deletion

PTPRK (4,376 words) [view diff] exact match in snippet view article find links to article

for PTPRK as a tumor suppressor. Assem and colleagues identified loss of heterozygosity (LOH) events in malignant glioma specimens, and identified PTPRK

Neuroblastoma (7,165 words) [view diff] exact match in snippet view article find links to article

including neuroblastomas, because they can detect copy neutral loss of heterozygosity (acquired uniparental disomy). Copy neutral LOH can be biologically

Randy Jirtle (1,716 words) [view diff] exact match in snippet view article find links to article

"M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity", Nat Genet 11: 447–449. PMID 7493029 Hankins GR, De Souza AT, Bentley

Glioma (6,986 words) [view diff] exact match in snippet view article find links to article

occurred prior to the occurrence of a p53 mutation or a 1p/19q loss of heterozygosity, indicating that an IDH1 mutation is an early driver mutation. High-grade

Scott Waldman (1,721 words) [view diff] exact match in snippet view article find links to article

"Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity". Cancer Biology & Therapy. 21 (9): 799–805. doi:10.1080/15384047

Mismatch repair endonuclease PMS2 (3,253 words) [view diff] exact match in snippet view article find links to article

have a heterozygous germline mutation in Pms2, followed by likely loss of heterozygosity in the tumor. Thus only 6 of 119 tumors lacking expression for Pms2

Chromatin remodeling (5,523 words) [view diff] exact match in snippet view article find links to article

reported in colorectal, pancreatic, breast and gastric carcinomas. Loss of heterozygosity in coding region of p300 (chromosome 22q13) is present in large

CPNE1 (1,863 words) [view diff] exact match in snippet view article find links to article

and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3". Genomics. 61 (2): 219–226. doi:10.1006/geno.1999.5958

Somatic evolution in cancer (9,928 words) [view diff] exact match in snippet view article find links to article

(SNP), sequence mutations, Microsatellite shifts and instability, loss of heterozygosity (LOH), Copy number variation (detected both by comparative genomic

Protein acetylation (4,895 words) [view diff] exact match in snippet view article find links to article

hNaa10 lung cancer, breast cancer, pancreatic cancer, ovarian cancer loss of heterozygosity in tumors hNaa10 breast cancer, gastric cancer, lung cancer high

Chromothripsis (3,134 words) [view diff] exact match in snippet view article find links to article

heterozygosity-two copy (no loss or gain), with regions that have loss of heterozygosity- one copy (heterozygous deletion). This suggests that the rearrangements

Leukoplakia (6,922 words) [view diff] exact match in snippet view article find links to article

M, Laronde DM, Berean K, Gardner PJ, et al. (September 2012). "Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral

GNMT (3,150 words) [view diff] exact match in snippet view article find links to article

TT, Yang S, Lin MW, Hsieh JT, Chen YM (March 2007). "Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate

BRCA2 (7,870 words) [view diff] exact match in snippet view article find links to article

with low mRNA expression and low protein expression but not with loss of heterozygosity of the gene. In sporadic ovarian cancer, an opposite effect is found

Species reintroduction (10,507 words) [view diff] exact match in snippet view article find links to article

success of a reintroduction program. Adverse genetic changes such as loss of heterozygosity may indicate management intervention, such as population supplementation

Woolly mammoth (18,923 words) [view diff] exact match in snippet view article find links to article

population of about 300 to 1,000 individuals led to a 20% to 30% loss of heterozygosity and a 65% loss in mitochondrial DNA diversity. The population seems

TCF21 (gene) (3,630 words) [view diff] exact match in snippet view article

Restriction landmark genomic scanning (RLGS) along a region of recurrent loss of heterozygosity (LOH) at chromosome 6q23-q24 to profile DNA methylation was used

Jens Nielsen (2,656 words) [view diff] exact match in snippet view article find links to article

PMID 15710883. Gatto F, Nookaew I, Nielsen J (2014). "Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal

Cell-free fetal DNA (5,955 words) [view diff] exact match in snippet view article find links to article

plasma with accuracy beyond that of real-time PCR. Point mutations, loss of heterozygosity and aneuploidy can be detected in a single PCR step. Digital PCR

Human somatic variation (3,219 words) [view diff] exact match in snippet view article find links to article

based techniques for screening genome-wide copy number variants and loss of heterozygosity in single cells showed that chromosome aneuploidies, uniparental

Thaddeus Dryja (3,553 words) [view diff] exact match in snippet view article find links to article

recombination map of 13cen–13q14 derived from an investigation of loss of heterozygosity in retinoblastomas". Proceedings of the National Academy of Sciences

Human germline engineering (6,512 words) [view diff] exact match in snippet view article find links to article

Dagan; Turner, James M. A.; Niakan, Kathy K. (June 2021). "Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos". Proceedings of the National

Circulating tumor DNA (5,861 words) [view diff] exact match in snippet view article find links to article

variations are common in cancers and describe situations where loss of heterozygosity of a gene may lead to decreased function due to lower expression

Cancer epigenetics (12,533 words) [view diff] exact match in snippet view article find links to article

nucleotide base, creating pyrimidine dimers. When mutation results in loss of heterozygosity at tumor suppressor gene sites, these genes may become inactive

SULF1 (6,584 words) [view diff] exact match in snippet view article find links to article

levels of Sulf1 mRNA. Less than half of HCC tumor samples showed loss of heterozygosity (LOH), and DNA methylation inhibition treatment of Sulf1 absent

SLC46A3 (6,550 words) [view diff] exact match in snippet view article find links to article

phosphoinositide 3-kinase (PI3K) signaling that leads to tumor growth. The loss of heterozygosity and mutations of CDP are also associated with a variety of cancers