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searching for Hsp90 inhibitor 14 found (19 total)

Chaperome (733 words) [view diff] exact match in snippet view article find links to article

adapting to stress including hypoxia and heat. The small molecule Hsp90 inhibitor, PU-H71, has been found to have a preferential binding to Hsp90 when

Radicicol (269 words) [view diff] case mismatch in snippet view article find links to article

"Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii". Chemistry & Biology

LYN (3,807 words) [view diff] case mismatch in snippet view article find links to article

rheostat that modulates signaling rather than as a binary on-off switch. HSP90 inhibitor NVP-BEP800 has been described to affect stability of LYN kinase and

Proto-oncogene tyrosine-protein kinase Src (2,794 words) [view diff] case mismatch in snippet view article find links to article

trials include bosutinib, bafetinib, AZD-0530, XLl-999, KX01 and XL228. HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine kinase

Paul Workman (scientist) (955 words) [view diff] exact match in snippet view article

cells, in particular, molecular chaperones such as Hsp90. The leading Hsp90 inhibitor was discovered by Workman's team at ICR in collaboration with Vernalis

Vernalis Research (1,160 words) [view diff] exact match in snippet view article find links to article

July 2015. Additionally, luminespib (AUY922) is a novel intravenous Hsp90 inhibitor with the potential to target a range of cancers, which arose from a

Lck (4,453 words) [view diff] case mismatch in snippet view article find links to article

have some impact on its therapeutic effects in canine mastocytoma. HSP90 inhibitor NVP-BEP800 has been described to affect stability of the LCK kinase

FNIP1 (707 words) [view diff] exact match in snippet view article find links to article

Trepel JB, Whitesell L, Picard D (July 2018). "Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches

Clusterin (2,433 words) [view diff] no match in snippet view article find links to article

that blocks the CLU mRNA transcript, enhanced heat-shock protein 90 (HSP90) inhibitor activity by suppressing the heat-shock response in castrate-resistant

Lutetium (177Lu) chloride (678 words) [view diff] case mismatch in snippet view article

Lundsten S, Spiegelberg D, Stenerlöw B, Nestor M (December 2019). "The HSP90 inhibitor onalespib potentiates 177Lu‑DOTATATE therapy in neuroendocrine tumor

List of pharmaceutical compound number prefixes (1,656 words) [view diff] case mismatch in snippet view article find links to article

Archived from the original on 2012-04-16. Retrieved 2012-04-17. "Exelixis HSP90 inhibitor XL888". Archived from the original on 2016-09-18. Retrieved 2016-09-16

Heat shock protein (5,525 words) [view diff] exact match in snippet view article find links to article

HSPs, especially Hsp90 show promise as anticancer agents. The potent Hsp90 inhibitor 17-AAG was in clinical trials for the treatment of several types of

Hsp70 (5,631 words) [view diff] exact match in snippet view article find links to article

et al. (June 2018). "Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art". Biomedicine & Pharmacotherapy

Heat shock protein 90kDa alpha (cytosolic), member A1 (8,175 words) [view diff] exact match in snippet view article

most amenable to inhibitor generation. To date, there are 23 active Hsp90 inhibitor oncology trials, and 13 HSP90 inhibitors are currently undergoing clinical