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Longer titles found: Non-allelic homologous recombination (view)

searching for Homologous recombination 210 found (602 total)

alternate case: homologous recombination

HFM1 (103 words) [view diff] exact match in snippet view article find links to article

HFM1 is a gene that in humans encodes a protein necessary for homologous recombination of chromosomes. Biallelic mutations in HFM1 cause recessive primary
Illegitimate recombination (1,044 words) [view diff] exact match in snippet view article find links to article
Illegitimate recombination, or nonhomologous recombination, is the process by which two unrelated double stranded segments of DNA are joined. This insertion
Delitto perfetto (1,545 words) [view diff] exact match in snippet view article find links to article
of homologous recombination. Consequently, it is well suited for genetic manipulation of yeast, which has highly efficient homologous recombination. The
SMC3 (939 words) [view diff] exact match in snippet view article find links to article
the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either
RAD54B (802 words) [view diff] exact match in snippet view article find links to article
Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and
Simon N. Powell (1,366 words) [view diff] exact match in snippet view article find links to article
Simon N (1997). "Inactivation of p53 results in high rates of homologous recombination". Oncogene. 14 (15): 1847–57. doi:10.1038/sj.onc.1201143. PMID 9150391
DNA polymerase nu (509 words) [view diff] exact match in snippet view article find links to article
2010). "DNA polymerase POLN participates in cross-link repair and homologous recombination". Molecular and Cellular Biology. 30 (4): 1088–96. doi:10.1128/MCB
Abortive transformation (96 words) [view diff] exact match in snippet view article find links to article
cerevisiae, where abortive transformants become formed during homologous recombination. Malignant transformation Mahy, Brian W. J. (2001). A Dictionary
Cochliobolus heterostrophus (191 words) [view diff] exact match in snippet view article find links to article
analysts lends itself to the organism's superior tractability when "homologous recombination between transforming DNA and target genomic sequences" takes place
PDS5B (595 words) [view diff] exact match in snippet view article find links to article
the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1
POLQ (1,456 words) [view diff] no match in snippet view article find links to article
R, Hajdu I, Primack B, Petalcorin MI, et al. (February 2015). "Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair". Nature
Laminin, gamma 1 (1,191 words) [view diff] exact match in snippet view article find links to article
which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain
SMC1A (2,075 words) [view diff] exact match in snippet view article find links to article
the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A,
Defective interfering particle (2,307 words) [view diff] exact match in snippet view article find links to article
particle's genome has been lost due to defective replication or non-homologous recombination. The mechanism of their formation is presumed to be as a result
WAPAL (634 words) [view diff] exact match in snippet view article find links to article
the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either
Host-cell reactivation (557 words) [view diff] exact match in snippet view article find links to article
UV-pretreated cells. This phenomenon was first thought to be the result of homologous recombination between both bacteria and phage, but later recognized as enzymatic
Nannochloropsis (2,925 words) [view diff] exact match in snippet view article find links to article
there has been evidence that some strains are able to perform homologous recombination. At the moment it is mainly used as an energy-rich food source
Ligation (molecular biology) (3,359 words) [view diff] no match in snippet view article
In molecular biology, ligation is the joining of two nucleic acid fragments through the action of an enzyme. It is an essential laboratory procedure in
RMI1 (713 words) [view diff] exact match in snippet view article find links to article
(2006). "BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates". Proc. Natl. Acad. Sci. U.S.A. 103 (11): 4068–73
RECQL5 (675 words) [view diff] exact match in snippet view article find links to article
H, Sung P, Luo G (Dec 2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic
Cre-Lox recombination (4,627 words) [view diff] exact match in snippet view article find links to article
strand on which it is present must find its complement. Since homologous recombination occurs after DNA replication, two strands of DNA are available
Leishmania infantum (553 words) [view diff] exact match in snippet view article find links to article
protein has been exploited to better understand its function in homologous recombination and its interaction with the LiRAD51 recombinase. Aoun, K.; Bouratbine
TONSL (581 words) [view diff] exact match in snippet view article find links to article
2010). "Identification of the MMS22L-TONSL complex that promotes homologous recombination". Molecular Cell. 40 (4): 632–44. doi:10.1016/j.molcel.2010.10
FANCB (850 words) [view diff] exact match in snippet view article find links to article
repair • positive regulation of double-strand break repair via homologous recombination • replication-born double-strand break repair via sister chromatid
ZGRF1 (1,687 words) [view diff] exact match in snippet view article find links to article
localizes to the cell nucleus and promotes DNA repair by stimulating homologous recombination. This gene shows relatively low expression in most human tissues
Cohesin (3,349 words) [view diff] exact match in snippet view article find links to article
is a protein complex that mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, SCC1 and SCC3
MMS22L (831 words) [view diff] exact match in snippet view article find links to article
2010). "Identification of the MMS22L-TONSL complex that promotes homologous recombination". Molecular Cell. 40 (4): 632–44. doi:10.1016/j.molcel.2010.10
RNA polymerase II (2,983 words) [view diff] exact match in snippet view article find links to article
the G1/G0 stages of the cell cycle, cells exhibit assembly of homologous recombination factors at double-strand breaks within actively transcribed regions
Replication protein A1 (1,507 words) [view diff] exact match in snippet view article find links to article
interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene. 23 (56): 9025–33. doi:10.1038/sj.onc.1207982. PMID 15489903
Replication protein A1 (1,507 words) [view diff] exact match in snippet view article find links to article
interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene. 23 (56): 9025–33. doi:10.1038/sj.onc.1207982. PMID 15489903
Anna Dumitriu (568 words) [view diff] exact match in snippet view article find links to article
Mend" in 2017 which uses the CRISPR gene editing technique of homologous recombination to edit the genome of E. coli bacteria to remove an antibiotic
Antigenic variation (3,244 words) [view diff] exact match in snippet view article find links to article
VSG expression site (ES). This process is partially dependent on homologous recombination of DNA, which is mediated in part by the interaction of the T.
HORMAD1 (682 words) [view diff] exact match in snippet view article find links to article
paper suggested that overexpression of HORMAD1 is a driver of homologous recombination repair deficiency in these types of breast cancers, and induced
Smith–Magenis syndrome (1,544 words) [view diff] exact match in snippet view article find links to article
region can be recurrent when alternate low-copy repeats act as homologous recombination substrates". American Journal of Human Genetics. 75 (1): 75–81
Podospora anserina (1,599 words) [view diff] exact match in snippet view article find links to article
depending on the specific strain. ΔPaKu70 is used to increase homologous recombination in protoplasts during transformations in order to create desirable
RAD51L1 (1,047 words) [view diff] exact match in snippet view article find links to article
evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with
2q37 monosomy (352 words) [view diff] exact match in snippet view article find links to article
that the 2q37 rearrangement is unlikely to be mediated by non-homologous recombination and low-copy repeats. In a study of 20 patients, no clear relationship
Heat-labile enterotoxin family (739 words) [view diff] exact match in snippet view article find links to article
flanking the elt genes provide extra transmission capabilities by homologous recombination at their inverted repeats. Οβ phage-induced conversion in E. coli
Novobiocin (2,167 words) [view diff] exact match in snippet view article find links to article
the loss of microhomology-mediated end joining as a pathway for homologous recombination deficient cells to circumvent DNA damaging agents. The action of
BRCA1 (14,067 words) [view diff] exact match in snippet view article find links to article
exposures, but also occur when chromosomes exchange genetic material (homologous recombination, e.g., "crossing over" during meiosis). The BRCA2 protein, which
RAD51L3 (1,327 words) [view diff] exact match in snippet view article find links to article
Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other
Mutant (746 words) [view diff] case mismatch in snippet view article find links to article
Berns MW, Wu X (May 2013). "Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand
GEN1, Holliday junction 5' flap endonuclease (635 words) [view diff] exact match in snippet view article find links to article
intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions
Coprinopsis cinerea (1,451 words) [view diff] exact match in snippet view article find links to article
silencing) ku70 homologue can increase gene targeting via increased homologous recombination. Either protoplasts derived from oidia or vegetative mycelium can
Scott N. Keeney (678 words) [view diff] exact match in snippet view article find links to article
Keeney's research focused on the mechanism and regulation of homologous recombination during meiosis. He discovered the function of a protein called
Jan Breslow (1,342 words) [view diff] exact match in snippet view article find links to article
atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells", Cell, 71 (2): 343–53, doi:10.1016/0092-8674(92)90362-g
PHKB (605 words) [view diff] exact match in snippet view article find links to article
PMID 9402963. S2CID 27661807. Burwinkel B, Kilimann MW (1998). "Unequal homologous recombination between LINE-1 elements as a mutational mechanism in human genetic
Replication protein A2 (1,477 words) [view diff] exact match in snippet view article find links to article
cross-link repair • regulation of double-strand break repair via homologous recombination • error-free translesion synthesis • G1 phase • error-prone translesion
Sister chromatids (583 words) [view diff] exact match in snippet view article find links to article
PMC 1205144. PMID 1427035. Moynahan ME, Jasin M (2010). "Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis". Nat
DNA polymerase lambda (1,127 words) [view diff] exact match in snippet view article find links to article
damage stimulus • DNA repair • double-strand break repair via homologous recombination • base-excision repair, gap-filling • double-strand break repair
AAVS1 (128 words) [view diff] exact match in snippet view article find links to article
chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination". The EMBO Journal. 11 (13): 5071–8. doi:10.1002/j.1460-2075.1992
SETX (1,814 words) [view diff] exact match in snippet view article find links to article
marker for DNA damage. Furthermore, SETX was observed to promote homologous recombination repair and prevent translocation. To further support SETX's role
RNASEH2B (1,306 words) [view diff] exact match in snippet view article find links to article
ribonucleotides: 1) diRibonucleotides in S. pombe may be a signal to initiate homologous recombination. 2) Ribonucleotides in mtDNA (Mouse and HeLa cells). Low levels
Simon Boulton (1,889 words) [view diff] exact match in snippet view article find links to article
crucial role in repairing double-stranded DNA breaks by means of homologous recombination (HR) – a discovery that has great therapeutic significance and
KDM2B (1,483 words) [view diff] exact match in snippet view article find links to article
repression at DNA lesions, double strand break signaling, and homologous recombination repair. The activity of the ncPRC1.1 complex at DNA lesions was
Natural competence (2,641 words) [view diff] exact match in snippet view article find links to article
well-conserved protein, DprA, which loads the DNA onto RecA, which mediates homologous recombination through the classic DNA repair pathway. In laboratory cultures
RPA4 (373 words) [view diff] exact match in snippet view article find links to article
maintenance via recombination • double-strand break repair via homologous recombination • DNA topological change • DNA unwinding involved in DNA replication
HDAC10 (645 words) [view diff] exact match in snippet view article find links to article
regulation of mismatch repair • peptidyl-lysine deacetylation • homologous recombination • polyamine deacetylation • spermidine deacetylation • DNA repair
Cees Dekker (1,506 words) [view diff] exact match in snippet view article find links to article
channel 2007, first real-time detection of strand exchange in homologous recombination by RecA; discovery of a low persistence length of ends of microtubules;
E3 binding protein (2,579 words) [view diff] exact match in snippet view article find links to article
Chuzhanova N, Marsac C (2006). "A novel gross deletion caused by non-homologous recombination of the PDHX gene in a patient with pyruvate dehydrogenase deficiency"
Phase variation (1,657 words) [view diff] exact match in snippet view article find links to article
the PilE gene. The silent versions of this gene, PilS, can use homologous recombination to combine with parts of the PilE gene and thus create a different
USP51 (374 words) [view diff] exact match in snippet view article find links to article
cell cycle process • regulation of double-strand break repair via homologous recombination • regulation of double-strand break repair via nonhomologous end
Phase variation (1,657 words) [view diff] exact match in snippet view article find links to article
the PilE gene. The silent versions of this gene, PilS, can use homologous recombination to combine with parts of the PilE gene and thus create a different
Chromosome X open reading frame 57 (77 words) [view diff] exact match in snippet view article find links to article
replication fork • chromosome Biological process • negative regulation of double-strand break repair via homologous recombination Sources:Amigo / QuickGO
ZNF365 (736 words) [view diff] exact match in snippet view article find links to article
telomere maintenance • regulation of double-strand break repair via homologous recombination • negative regulation of neuron projection development • cerebellar
Thermococcus kodakarensis (658 words) [view diff] exact match in snippet view article find links to article
Atomi H, Imanaka T (January 2003). "Targeted gene disruption by homologous recombination in the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1"
NBPF15 (553 words) [view diff] exact match in snippet view article find links to article
conservation, both in coding and noncoding regions. Makes it possible for homologous recombination to occur easily between different alleles. The repetitiveness of
H2AFX (2,601 words) [view diff] exact match in snippet view article find links to article
Hoeijmakers JH, Kanaar R (2002). "Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage". EMBO J. 21 (8): 2030–7. doi:10
Lorraine Potocki (102 words) [view diff] exact match in snippet view article find links to article
(January 2000). "Molecular mechanism for duplication 17p11.2 - the homologous recombination reciprocal of the Smith–Magenis microdeletion". Nature Genetics
Laminin, beta 2 (1,362 words) [view diff] exact match in snippet view article find links to article
Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and
Gene knockdown (1,603 words) [view diff] exact match in snippet view article find links to article
"Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination". Nucleic Acids Research. 41 (20): e193. doi:10.1093/nar/gkt805
UBE2N (1,070 words) [view diff] exact match in snippet view article find links to article
histone ubiquitination • DNA repair • double-strand break repair via homologous recombination • JNK cascade • positive regulation of NF-kappaB transcription
KDM4D (400 words) [view diff] exact match in snippet view article find links to article
regulation of chromatin binding • double-strand break repair via homologous recombination • transcription, DNA-templated • positive regulation of double-strand
Branch migration (740 words) [view diff] exact match in snippet view article find links to article
"Three-dimensional structural views of branch migration and resolution in DNA homologous recombination". Current Opinion in Structural Biology. 14 (2): 130–137. doi:10
NABP1 (334 words) [view diff] exact match in snippet view article find links to article
response to ionizing radiation • double-strand break repair via homologous recombination • DNA repair • cellular response to DNA damage stimulus • snRNA
Cell cycle checkpoint (4,567 words) [view diff] exact match in snippet view article find links to article
shown to precede lymphoma development presumably due to excessive homologous recombination, leading to high genomic instability. Disruption of Chk1 in mice
MMS19 (588 words) [view diff] exact match in snippet view article find links to article
transfer • positive regulation of double-strand break repair via homologous recombination • positive regulation of signal transduction Sources:Amigo / QuickGO
Maelstrom gene (449 words) [view diff] exact match in snippet view article find links to article
the mammalian homolog of Drosophila’s Maelstrom, was created by homologous recombination in mice to create Mael null mice. In the knockout mice, meiotic
SMCHD1 (319 words) [view diff] exact match in snippet view article find links to article
silencing • negative regulation of double-strand break repair via homologous recombination • positive regulation of double-strand break repair via nonhomologous
NUCKS1 (659 words) [view diff] exact match in snippet view article find links to article
replication • gene conversion • double-strand break repair via homologous recombination • regulation of transcription by RNA polymerase II • replication
NgAgo (718 words) [view diff] exact match in snippet view article find links to article
manufacturing". April 3, 2019. Solomon, Kevin (2019). "NgAgo-enhanced homologous recombination in E. coli is mediated by DNA endonuclease activity". bioRxiv:
REC8 (734 words) [view diff] exact match in snippet view article find links to article
at meiosis • oocyte maturation • double-strand break repair via homologous recombination • synaptonemal complex assembly • spermatogenesis • spermatid development
Lorraine S. Symington (302 words) [view diff] case mismatch in snippet view article find links to article
Academy of Sciences for her genetics research. "Mechanisms of Homologous Recombination". mendellectures.muni.cz. Retrieved March 15, 2021. Lee, Andrew
Saint Louis encephalitis (1,245 words) [view diff] exact match in snippet view article find links to article
PMID 11811684. S2CID 24755534. Twiddy SS, Holmes EC (2003). "The extent of homologous recombination in members of the genus Flavivirus". J. Gen. Virol. 84 (Pt 2):
Edible vaccines (2,294 words) [view diff] exact match in snippet view article find links to article
transferred and integrated into the genomic DNA of the host plant by non-homologous recombination at random sites. This method has a low yield and is a slow process
Genome (6,479 words) [view diff] exact match in snippet view article find links to article
eukaryotes because their insertion can disrupt gene functions, homologous recombination between TEs can produce duplications, and TE can shuffle exons
Abexinostat (440 words) [view diff] exact match in snippet view article find links to article
"HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination". Proceedings of the National Academy of Sciences of the United
Niraparib (1,250 words) [view diff] exact match in snippet view article find links to article
prior chemotherapy regimens and whose cancer is associated with homologous recombination deficiency (HRD)-positive status. HRD is defined by either a deleterious
DPY19L2 (496 words) [view diff] exact match in snippet view article find links to article
"Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots". Human Molecular Genetics
Endonuclease/exonuclease/phosphatase family domain containing 1 (257 words) [view diff] case mismatch in snippet view article find links to article
and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair". PLOS Genet. 11 (12): e1005675. doi:10.1371/journal.pgen
Telomere-associated protein RIF1 (526 words) [view diff] exact match in snippet view article find links to article
switching • negative regulation of double-strand break repair via homologous recombination • positive regulation of double-strand break repair via nonhomologous
ZFYVE26 (701 words) [view diff] exact match in snippet view article find links to article
division • cell cycle • cytokinesis • double-strand break repair via homologous recombination • DNA repair • cellular response to DNA damage stimulus • mitotic
MDC1 (3,021 words) [view diff] exact match in snippet view article find links to article
phosphorylation by the DRR kinases (ATM, CHK1, CHK2), defects in homologous recombination. Human cells with silenced MDC1 also displayed random plasmid integration
UBE2V2 (1,677 words) [view diff] exact match in snippet view article find links to article
role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination". Molecular Cell. 25 (5): 663–75. doi:10.1016/j.molcel.2007.01
Helicase, POLQ-like (513 words) [view diff] exact match in snippet view article find links to article
cytoplasm Biological process • double-strand break repair via homologous recombination • DNA repair • cellular response to DNA damage stimulus • RNA secondary
Replication protein A3 (920 words) [view diff] exact match in snippet view article find links to article
repair • base-excision repair • double-strand break repair via homologous recombination • nucleotide-excision repair, preincision complex assembly • telomere
Streptomyces albidoflavus (1,076 words) [view diff] case mismatch in snippet view article find links to article
Analysis of Streptomyces albidoflavus Reveals Habitat Barriers to Homologous Recombination in the Diversification of Streptomycetes". Applied and Environmental
PPP4C (1,093 words) [view diff] exact match in snippet view article find links to article
Biological process • regulation of double-strand break repair via homologous recombination • NIK/NF-kappaB signaling • protein dephosphorylation Sources:Amigo
Ketan J. Patel (1,479 words) [view diff] exact match in snippet view article find links to article
Patel, K. J. (2004). "The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair". Molecular Cell. 15 (4): 607–20. doi:10
Chordoma (1,893 words) [view diff] exact match in snippet view article find links to article
Russell RB, Glimm H, Schlesner M, Fröhling S (2019) Defective homologous recombination DNA repair as therapeutic target in advanced chordoma. Nat Commun
Blue cone monochromacy (3,490 words) [view diff] exact match in snippet view article find links to article
within the genes OPN1LW and OPN1MW and a 2 steps mechanism with an homologous recombination and a punctual inactivation. The point mutation is the so-called
MORF4L1 (1,033 words) [view diff] exact match in snippet view article find links to article
response to DNA damage stimulus • double-strand break repair via homologous recombination • histone H4 acetylation • regulation of growth • histone deacetylation
MAD2L2 (1,001 words) [view diff] exact match in snippet view article find links to article
switching • negative regulation of double-strand break repair via homologous recombination • positive regulation of double-strand break repair via nonhomologous
SHFM1 (832 words) [view diff] exact match in snippet view article find links to article
post-translational protein modification • double-strand break repair via homologous recombination • MAPK cascade • protein polyubiquitination • stimulatory C-type
Carpediemonas (1,458 words) [view diff] exact match in snippet view article find links to article
short: replication is proposed to proceed by a Dmc1-dependent homologous recombination mechanism that does not require origins of replication and that
Chromatin bridge (1,030 words) [view diff] exact match in snippet view article find links to article
occur is the failure to resolve joint molecules formed during homologous recombination mediated DNA repair, a process that ensures that replicated chromosomes
Proliferating cell nuclear antigen (5,881 words) [view diff] exact match in snippet view article find links to article
that is thought to involve damage bypass by recruitment of the homologous recombination machinery. PCNA is pivotal to the activation of these pathways
Benedikt Kessler (1,794 words) [view diff] exact match in snippet view article find links to article
& Jackson, S. P. (2015). USP4 auto-deubiquitylation promotes homologous recombination. Molecular Cell, 60(3), 362-373. Iglesias-Gato, D., Chuan, Y. -C
Missense mRNA (1,012 words) [view diff] exact match in snippet view article find links to article
measured to model genetic diseases and discover novel drugs. While homologous recombination has been widely used to generate single-base substitutions, novel
Susan M. Gasser (1,983 words) [view diff] exact match in snippet view article find links to article
Increased dynamics of double strand breaks requires Mec1, Rad9 and the homologous recombination machinery. Nat. Cell Biol. 14:502-509, Dion V, Kalck V, Horigome
Hayflick limit (1,906 words) [view diff] case mismatch in snippet view article find links to article
Wang, Richard C.; Smogorzewska, Agata; De Lange, Titia (2004). "Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres". Cell. 119
RECQL (896 words) [view diff] exact match in snippet view article find links to article
DNA recombination • DNA repair • double-strand break repair via homologous recombination • DNA duplex unwinding • DNA unwinding involved in DNA replication
Conditional gene knockout (1,292 words) [view diff] exact match in snippet view article find links to article
strategies to conditional gene knockout and those are gene targeting or homologous recombination and gene trapping. Both methods usually have a modified viral vector
Sponastrime dysplasia (690 words) [view diff] exact match in snippet view article find links to article
MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell 40(4):619-631 Fanconi CI, Giedion A, Prader A. (1983)
Animesh Ray (711 words) [view diff] exact match in snippet view article find links to article
recombination. In 1989 Animesh Ray published on mechanisms of homologous recombination induced by a DNA double strand break using HIS3 gene of Saccharomyces
Slx1 structure-specific endonuclease subunit homolog b (s. cerevisiae) (175 words) [view diff] exact match in snippet view article
bond hydrolysis • DNA repair • double-strand break repair via homologous recombination • telomere maintenance via telomere lengthening • t-circle formation
COTL1 (980 words) [view diff] exact match in snippet view article find links to article
Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR (Nov 1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous
Paramecium (3,030 words) [view diff] exact match in snippet view article find links to article
accurate processing and repair of double-strand breaks during homologous recombination. Play media Paramecium bursaria, a species with symbiotic algae
PRDM9 (2,016 words) [view diff] exact match in snippet view article find links to article
PRDM9 mediates the process of meiosis by directing the sites of homologous recombination. In humans and mice, recombination does not occur evenly throughout
Titia de Lange (1,632 words) [view diff] case mismatch in snippet view article find links to article
org/content/10/2/518.long Wang, R. C., Smogorzewska, A., & Lange, T. De. (2004). Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres, 119, 355–368
Kalappa Muniyappa (944 words) [view diff] exact match in snippet view article find links to article
credited with the discovery of a negative regulatory mechanism of homologous recombination. His contributions in deciphering genetic recombination in mycobacterium
Walker motifs (1,264 words) [view diff] exact match in snippet view article find links to article
S2CID 27830342. Bugreev DV, Mazin AV (July 2004). "Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity". Proceedings of
Thymineless death (712 words) [view diff] exact match in snippet view article find links to article
pulsed field gel electrophoresis and evidence for involvement of homologous recombination". Journal of Molecular Biology. 243 (4): 611–620. doi:10
Dermal fibroblast (1,507 words) [view diff] exact match in snippet view article find links to article
pluripotent [stem cells], corrected the genetic deficiency by homologous recombination, and redirected these pluripotent cells toward the hematopoietic
YY1 (1,917 words) [view diff] exact match in snippet view article find links to article
response to DNA damage stimulus • double-strand break repair via homologous recombination • spermatogenesis • DNA repair • protein deubiquitination • negative
HUS1 (1,406 words) [view diff] exact match in snippet view article find links to article
ionizing radiation • response to UV • double-strand break repair via homologous recombination • DNA damage checkpoint signaling • DNA repair • embryo development
Salmonella virus P22 (1,286 words) [view diff] exact match in snippet view article find links to article
host infection, the linear P22 virion DNA is circularized by a homologous recombination event between the direct repeats at both ends of the chromosome
Gene knock-in (1,568 words) [view diff] exact match in snippet view article find links to article
Mario Capecchi. Traditionally, knock-in techniques have relied on homologous recombination to drive targeted gene replacement, although other methods using
Embryonic stem cell (7,628 words) [view diff] exact match in snippet view article find links to article
(September 2008). "DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells". Cell Cycle. 7 (18): 2902–6.
Pathogen (3,882 words) [view diff] exact match in snippet view article find links to article
2005). "Comparative and evolutionary analysis of the bacterial homologous recombination systems". PLoS Genetics. 1 (2): e15. doi:10.1371/journal.pgen.0010015
TERF2IP (1,161 words) [view diff] exact match in snippet view article find links to article
joining at telomere • regulation of double-strand break repair via homologous recombination • transcription, DNA-templated • positive regulation of peptidyl-serine
Poly (ADP-ribose) polymerase (3,041 words) [view diff] exact match in snippet view article
leading to replication-associated lesions that cannot be repaired if homologous recombination repair (HRR) is defective, and leading to the synthetic lethality
RUVBL2 (1,241 words) [view diff] exact match in snippet view article find links to article
RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether
Splicing factor proline and glutamine rich (473 words) [view diff] exact match in snippet view article find links to article
regulation of circadian rhythm • double-strand break repair via homologous recombination • RNA splicing • positive regulation of oxidative stress-induced
G3BP1 (1,172 words) [view diff] exact match in snippet view article find links to article
J, Hill M (1993). "Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different
RBBP8 (1,772 words) [view diff] exact match in snippet view article find links to article
transcription by RNA polymerase II • double-strand break repair via homologous recombination • negative regulation of G0 to G1 transition • negative regulation
Orlando D. Schärer (1,123 words) [view diff] exact match in snippet view article find links to article
this fellowship, he researched biochemical and genetic aspects of homologous recombination in mammals. Starting in 1999, he was an independent group leader
Chironomidae (3,114 words) [view diff] exact match in snippet view article find links to article
and during rehydration. The Rad51 protein plays a key role in homologous recombination, a process required for the accurate repair of DNA double-strand
Mendel Lectures (853 words) [view diff] exact match in snippet view article find links to article
Columbia University Medical Center, New York, USA "Mechanisms of homologous recombination" 12 84 March 5, 2015 Herbert Waldmann Max Planck Institute of Molecular
KDM1A (1,709 words) [view diff] exact match in snippet view article find links to article
class mediator • regulation of double-strand break repair via homologous recombination • cellular response to UV • histone H3-K4 demethylation • regulation
Restriction modification system (2,558 words) [view diff] exact match in snippet view article find links to article
associated with restriction modification systems that modulate homologous recombination". Proc. Natl. Acad. Sci. U.S.A. 108 (11): 4494–9. Bibcode:2011PNAS
Synthetic genetic array (1,259 words) [view diff] exact match in snippet view article find links to article
save lots of time. At Early stage, mutant creation was done by homologous recombination method. We have an excellent mutant library for Saccharomyces cerevisiae
HEK 293 cells (2,814 words) [view diff] exact match in snippet view article find links to article
genes (typically, E1 and E3) are deleted, such as AdEasy. However, homologous recombination between the inserted cellular Ad5 sequence and the vector sequence
SLX4IP (1,356 words) [view diff] exact match in snippet view article find links to article
for the extension of telomeres as it is a RecQ helicase vital to homologous recombination and DNA replication. In DNA, Interstrand crosslinks (ICLs) are
GYPB (3,578 words) [view diff] exact match in snippet view article find links to article
organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences". Proc. Natl. Acad. Sci. U.S.A. 86 (12):
Heterogeneous ribonucleoprotein particle (2,015 words) [view diff] case mismatch in snippet view article find links to article
Heterogeneous Nuclear Ribonucleoprotein C for BRCA Gene Expression and Homologous Recombination". PLOS ONE. 8 (4): e61368. Bibcode:2013PLoSO...861368A. doi:10
Collagen, type III, alpha 1 (3,414 words) [view diff] exact match in snippet view article find links to article
have been reported. Inactivation of the murine Col3a1 gene using homologous recombination technique led to a shorter life span in homozygous mutant mice
Wiskott–Aldrich syndrome protein (2,580 words) [view diff] exact match in snippet view article find links to article
interferon-gamma • positive regulation of double-strand break repair via homologous recombination • regulation of double-strand break repair via nonhomologous end
Viroid (3,033 words) [view diff] case mismatch in snippet view article find links to article
H, et al. (May 2013). "Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand
Prokaryote (4,759 words) [view diff] exact match in snippet view article find links to article
transfer among cells to provide increased repair of damaged DNA via homologous recombination. While prokaryotes are considered strictly unicellular, most can
Artemis (protein) (1,832 words) [view diff] exact match in snippet view article
Jeggo PA, Löbrich M (November 2009). "ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2". EMBO J. 28
PNKP (1,877 words) [view diff] exact match in snippet view article find links to article
DNA double-strand breaks by nonhomologous end joining but not homologous recombination". Cancer Res. 67 (14): 6619–25. doi:10.1158/0008-5472.CAN-07-0480
Cell wall (4,734 words) [view diff] exact match in snippet view article find links to article
cell walls are variable, contained in tandem repeats subject to homologous recombination. An alternative scenario is that fungi started with a chitin-based
Mutagenesis (4,174 words) [view diff] exact match in snippet view article find links to article
topoisomerase II, blocking replication as well as causing mitotic homologous recombination. Transposons and viruses may insert DNA sequences into coding regions
Christian Karsten Hansen (1,271 words) [view diff] exact match in snippet view article find links to article
Diderichsen Børge (1990). "Gene : In vivo genetic engineering: homologous recombination as a tool for plasmid construction". Gene. 96 (1): 37–41. doi:10
Transcription activator-like effector nuclease (3,140 words) [view diff] exact match in snippet view article find links to article
E (2014). "Generation of TALEN-mediated GRdim knock-in rats by homologous recombination". PLOS ONE. 9 (2): e88146. Bibcode:2014PLoSO...988146P. doi:10
Ensifer meliloti (2,708 words) [view diff] exact match in snippet view article find links to article
Cleyet-Marel JC, Béna G (July 2007). "Horizontal gene transfer and homologous recombination drive the evolution of the nitrogen-fixing symbionts of Medicago
Intragenomic conflict (2,208 words) [view diff] exact match in snippet view article find links to article
homing endonuclease and the double-strand break are repaired by homologous recombination (gene conversion) using the allele containing HEGs as template
Elliott D. Kieff (1,380 words) [view diff] exact match in snippet view article find links to article
Albee Professorship. He established the utility of second site homologous recombination for genetic analyses that identified the essential EBV genes for
Chlamydomonas reinhardtii (3,357 words) [view diff] exact match in snippet view article find links to article
active diffusion phenomenon. Gene transformation occurs mainly by homologous recombination in the chloroplast and heterologous recombination in the nucleus
Jennifer Loros (1,169 words) [view diff] exact match in snippet view article find links to article
gene markers in such a manner as to make identification of low homologous recombination rates possible, which had previously not been the case when using
Insert (molecular biology) (1,356 words) [view diff] exact match in snippet view article
common technique to add inserts to desired sequences is the use of homologous recombination. This technique has a specific requirement where the insert can
BMI1 (2,595 words) [view diff] exact match in snippet view article find links to article
radiation sensitive and impaired repair of DNA double-strand breaks by homologous recombination. Bmi1 is necessary for efficient self-renewing cell divisions of
Ralph L. Brinster (3,807 words) [view diff] exact match in snippet view article find links to article
scientific progress in genetic modification via transgenesis, homologous recombination or "knock-out" techniques, and cloning; and the egg culture and
COX10 (1,370 words) [view diff] exact match in snippet view article find links to article
JR (September 1997). "The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs". Human Molecular
Evolution of the domesticated cat (1,861 words) [view diff] exact match in snippet view article find links to article
involved in neuronal processes (fear and reward behavior) and in homologous recombination (increased recombination frequency). In addition, the KIT mutations
Cingulin (2,059 words) [view diff] exact match in snippet view article find links to article
stem cells where one or both cingulin alleles were targeted by homologous recombination show apparently normal tight junctions, but changes in the expression
SMARCA4 (2,707 words) [view diff] exact match in snippet view article find links to article
interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2". Journal of
Helicobacter pylori (14,252 words) [view diff] exact match in snippet view article find links to article
conditions including those that cause DNA damage. In H. pylori, homologous recombination is required for repairing DNA double-strand breaks (DSBs). The
CHEK1 (3,416 words) [view diff] exact match in snippet view article find links to article
centrosome separation • regulation of double-strand break repair via homologous recombination • phosphorylation • replicative senescence • cellular response
Spiroplasma phage 1-R8A2B (1,376 words) [view diff] exact match in snippet view article find links to article
SpV1-derived cloning vector: deletion formation by illegitimate and homologous recombination in a spiroplasmal host strain which probably lacks a functional
Knockout rat (3,265 words) [view diff] exact match in snippet view article find links to article
they stimulate the cell’s natural DNA-repair processes, namely homologous recombination and non-homologous end joining. When the cell uses the non-homologous
Glycophorin A (4,099 words) [view diff] exact match in snippet view article find links to article
organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences". Proc. Natl. Acad. Sci. U.S.A. 86 (12):
PSMD14 (2,791 words) [view diff] exact match in snippet view article find links to article
deubiquitination • NIK/NF-kappaB signaling • double-strand break repair via homologous recombination • anaphase-promoting complex-dependent catabolic process • response
Marker-assisted selection (2,941 words) [view diff] exact match in snippet view article find links to article
markers are used in order to reduce the chances of an error due to homologous recombination. For example, if two flanking markers are used at same time with
Extremophile (5,841 words) [view diff] exact match in snippet view article find links to article
between Sulfolobus cells in order to repair damaged DNA by means of homologous recombination. Van Wolferen et al. noted that this DNA exchange process may be
SHLD1 (1,442 words) [view diff] exact match in snippet view article find links to article
switching • negative regulation of double-strand break repair via homologous recombination • positive regulation of double-strand break repair via nonhomologous
Roger Brent (1,630 words) [view diff] exact match in snippet view article find links to article
Kim, Y. G.; Chandrasegaran, S. (January 2001). "Stimulation of homologous recombination through targeted cleavage by chimeric nucleases". Mol Cell Biol
RNA-binding protein FUS (3,942 words) [view diff] exact match in snippet view article find links to article
regulation of nucleic acid-templated transcription • positive regulation of double-strand break repair via homologous recombination Sources:Amigo / QuickGO
Radiobiology evidence for protons and HZE nuclei (2,873 words) [view diff] exact match in snippet view article find links to article
repair of DSB is known to occur through direct end-joining and homologous recombination processes. Indications are that: for high-LET radiation, where
FAM43A (1,626 words) [view diff] exact match in snippet view article find links to article
caused by interstitial deletions of 3q29, mediated by nonallelic homologous recombination between low-copy repeats resulting in a common deletion. 3q29 microdeletion
CHD1 (1,887 words) [view diff] exact match in snippet view article find links to article
recruitment of DNA repair factors, thus facilitating DNA repair by homologous recombination. CHD1 has several genetic interactions with numerous factors involved
Genome size (4,631 words) [view diff] exact match in snippet view article find links to article
larger portion of sequence are more easily to be seen in during homologous recombination compared to the illegitimate, therefore the spread of the transposable
CRISPR interference (2,938 words) [view diff] exact match in snippet view article find links to article
provider, can be directly integrated into the E. coli genome without homologous recombination occurring, and can simultaneously target many genes to achieve
Gene transfer agent (2,408 words) [view diff] exact match in snippet view article find links to article
to the incoming DNA, it replaces the former with the latter by homologous recombination, mediated by the cell's RecA protein. If the sequences are not
XRCC1 (2,842 words) [view diff] exact match in snippet view article find links to article
response to organic substance • double-strand break repair via homologous recombination • response to drug • cellular response to DNA damage stimulus •
Regulation of transcription in cancer (2,363 words) [view diff] exact match in snippet view article find links to article
I, Keilholz U (2016). "Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an
Neisseria gonorrhoeae (4,643 words) [view diff] exact match in snippet view article find links to article
Cahoon, Laty A.; Seifert, H. Steven (September 2011). "Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria: Pilin antigenic
Mating of yeast (3,254 words) [view diff] exact match in snippet view article find links to article
interchromosomal mating-type switching but not in interchromosomal homologous recombination". Genetics. 166 (3): 1187–97. doi:10.1534/genetics.166.3.1187.
Structural variation in the human genome (3,756 words) [view diff] exact match in snippet view article find links to article
sequences on a chromosome increases the probability of non allelic homologous recombination. These repeated sequences could cause deletions, duplications,
Human germline engineering (6,779 words) [view diff] exact match in snippet view article find links to article
effectively cleave the β-globin gene (HBB), the efficiency of homologous recombination directed repair of HBB was highly inefficient and did not do so
Species (9,129 words) [view diff] exact match in snippet view article find links to article
consisting of asexually reproducing populations that exchange genes by homologous recombination. A species is extinct when the last individual of that species
P53 (13,683 words) [view diff] exact match in snippet view article find links to article
Knippschild U, Buchhop S (April 1996). "p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction". The EMBO Journal
PFKFB3 (3,708 words) [view diff] exact match in snippet view article find links to article
"Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination". Nature Communications. 9 (1): 3872. doi:10.1038/s41467-018-06287-x
DNA replication (6,655 words) [view diff] exact match in snippet view article find links to article
Replication fork restarts by homologous recombination following replication stress
CpG site (5,424 words) [view diff] exact match in snippet view article find links to article
Tinhofer I, et al. (2016). "Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an
Origin of replication (12,929 words) [view diff] exact match in snippet view article find links to article
bacteriophages and viruses, for example, can initiate DNA replication by homologous recombination independent of dedicated origins. Likewise, the archaeon Haloferax
Helitron (biology) (3,776 words) [view diff] exact match in snippet view article
Joining is more frequent in plants and mammals than repair through homologous recombination, and is often accompanied by insertions of 100–4000 bp long “filler
Chromosome instability (3,332 words) [view diff] exact match in snippet view article find links to article
segregate incorrect chromosomes. Faulty rearrangements can occur when homologous recombination fails to accurately repair double-stranded breaks. Since human
Luther Burbank (4,847 words) [view diff] exact match in snippet view article find links to article
inbred varieties for breeding. Classical breeding relies largely on homologous recombination between chromosomes to generate genetic diversity. The classical
ATM serine/threonine kinase (5,040 words) [view diff] exact match in snippet view article find links to article
• cellular response to X-ray • double-strand break repair via homologous recombination • regulation of apoptotic process • negative regulation of TORC1
DNA read errors (1,806 words) [view diff] case mismatch in snippet view article find links to article
Recombination and Genome Rearrangements: Intersection Between Homologous Recombination, DNA Replication and DNA Repair. Academic Press. 2018-03-06.
B. J. Rao (881 words) [view diff] exact match in snippet view article find links to article
are also dissecting the biochemical mechanism of regulation of homologous recombination by tumour suppressors such as P53 and BRCA2 proteins. Other activities
RELA (6,551 words) [view diff] exact match in snippet view article find links to article
TAF4B, TBP, TP53, and TRIB3. Gene knockout of NF-κB genes via homologous recombination in mice showed the role of these components in innate and adaptive
Leishmania (5,159 words) [view diff] exact match in snippet view article find links to article
(August 2012). "Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum". Nucleic Acids Res. 40 (14): 6570–84. doi:10
Molecular lesion (3,531 words) [view diff] exact match in snippet view article find links to article
interphase, S-phase specific SSBR processes work together with homologous recombination at the replication forks. Double stranded breaks (DSB) are a threat
Ovarian cancer (17,981 words) [view diff] exact match in snippet view article find links to article
important for cancer to develop. In 50% of high-grade serous cancers, homologous recombination DNA repair is dysfunctional, as are the notch and FOXM1 signaling
SMIM23 (1,812 words) [view diff] exact match in snippet view article find links to article
complex, a complex required for double-strand break repair via homologous recombination. COL17A1 is collagen. Specifically type XVII, alpha 1. This may
Bevacizumab (6,560 words) [view diff] exact match in snippet view article find links to article
platinum-based chemotherapy and whose cancer is associated with homologous recombination deficiency positive status defined by either a deleterious or suspected
SAMHD1 (2,776 words) [view diff] exact match in snippet view article find links to article
deoxyribonucleotide catabolic process • double-strand break repair via homologous recombination • DNA replication • DNA repair • cellular response to DNA damage