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searching for Globin 331 found (414 total)

alternate case: globin

Thalassemia (6,571 words) [view diff] exact match in snippet view article find links to article

of two ζ globins (zeta globins) and two ε globins (epsilon globins) (ζ2ε2) Hb Gower-2, composed of two alpha globins and two epsilon globins (α2ε2) Hb
Alpha-thalassemia (1,581 words) [view diff] exact match in snippet view article find links to article
sees that α thalassemias results in decreased alpha-globin production, therefore fewer alpha-globin chains are produced, resulting in an excess of β chains
KLF2 (2,219 words) [view diff] exact match in snippet view article find links to article
genes is normal in EKLF-deficient mice, and since all genes on the human β-globin locus exhibit the CACCC elements, researchers began searching for other
TFCP2 (1,478 words) [view diff] exact match in snippet view article find links to article
Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene. TFCP2 is also called Late SV40 factor (LSF) and it is induced
Beta thalassemia (4,880 words) [view diff] exact match in snippet view article find links to article
insertions near or upstream of the β globin gene. Most often, mutations occur in the promoter regions preceding the beta-globin genes. Less often, abnormal splice
Protein subunit (781 words) [view diff] exact match in snippet view article find links to article
hemoglobin is a symmetrical arrangement of two identical α-globin subunits and two identical β-globin subunits. Longer multimeric proteins such as microtubules
KLF1 (1,159 words) [view diff] exact match in snippet view article find links to article
Procurement Globin Chain Production It has also been linked to three main processes that are all essential to transcription of the β globin gene: Chromatin
Alice in Chains: AIC 23 (666 words) [view diff] exact match in snippet view article find links to article
vocalist William DuVall), black metal musician Unta Gleeben Glabben Globben Globin (played by bassist Mike Inez), and hipster blogger Stanley Eisen (played
Hemoglobinopathy (2,206 words) [view diff] exact match in snippet view article find links to article
globins and two ε (epsilon) globins, i.e., ζ2ε2 Hb Gower-2, composed of two α globins and two ε globins (α2ε2) Hb Portland, composed of two ζ globins
Insulator (genetics) (2,064 words) [view diff] exact match in snippet view article
the β-globin locus. The CTCF insulator is especially important in vertebrates, while the gypsy insulator is implicated in Drosophila. The β-globin locus
Hereditary persistence of fetal hemoglobin (474 words) [view diff] exact match in snippet view article find links to article
interferes with HbS polymerization. HPFH can be caused by mutations in the β globin gene cluster, or the γ gene promoter region. In addition HbF levels are
OR51M1 (391 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
Locus control region (899 words) [view diff] exact match in snippet view article find links to article
manner and is tissue-specific, as seen in the selective expression of β-globin genes in erythroid cells. Expression levels of genes can be modified by
Delta-beta thalassemia (655 words) [view diff] exact match in snippet view article find links to article
by deletions of the entire delta and beta genes sequences and only gamma-globin and HbF are formed. Rarely, non-deletional forms have been reported. When
Hemoglobin Lepore syndrome (1,230 words) [view diff] exact match in snippet view article find links to article
normal alpha globin chains (HBA) and two delta-beta globin fusion chains which occurs due to a "crossover" between the delta (HBD) and beta globin (HBB) gene
DLX4 (1,079 words) [view diff] exact match in snippet view article find links to article
revealed that one encoded isoform (BP1) functions as a repressor of the beta-globin gene while the other isoform lacks that function. GRCh38: Ensembl release
OR51B4 (359 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
Sickle cell trait (2,892 words) [view diff] exact match in snippet view article find links to article
have been studies that show changes in the globin genes. There have been noted changes in the beta-globin sequence, to what is known as the sickle hemoglobin
HBAP1 (450 words) [view diff] exact match in snippet view article find links to article
1016/0022-2836(85)90039-7. PMID 2411938. Safaya S, Rieder RF (1988). "Dysfunctional alpha-globin gene in hemoglobin H disease in blacks. A dinucleotide deletion produces
OR51B2 (464 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
OR51I1 (361 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
OR52D1 (466 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
Gene family (2,025 words) [view diff] exact match in snippet view article find links to article
genes are in two clusters on different chromosomes, called the α-globin and β-globin loci. These two gene clusters are thought to have arisen as a result
OR51B6 (336 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
Titia de Lange (1,654 words) [view diff] exact match in snippet view article find links to article
University. De Lange obtained her Masters on "Chromatin structure of the human β-globin gene locus" at the University of Amsterdam in 1981, and subsequently her
OR51I2 (361 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
OR51B5 (339 words) [view diff] exact match in snippet view article find links to article
of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes"
KLF11 (1,397 words) [view diff] exact match in snippet view article find links to article
(KLF) family. It binds to SP1- like GC- rich sequences in epsilon and gamma globin gene promoters inhibiting cellular growth and causing apoptosis. In the
Mentzer index (293 words) [view diff] exact match in snippet view article find links to article
be greater than 13. Conversely, in thalassemia, which is a disorder of globin synthesis, the number of RBCs produced is normal, but the cells are smaller
Interspersed repeat (535 words) [view diff] exact match in snippet view article find links to article
organization L1Base Schimenti JC, Duncan CH (February 1984). "Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats". Nucleic
Point mutation (4,359 words) [view diff] exact match in snippet view article find links to article
position. The β-globin gene is found on the short arm of chromosome 11. The association of two wild-type α-globin subunits with two mutant β-globin subunits
Point mutation (4,359 words) [view diff] exact match in snippet view article find links to article
position. The β-globin gene is found on the short arm of chromosome 11. The association of two wild-type α-globin subunits with two mutant β-globin subunits
Sickle cell disease (15,198 words) [view diff] exact match in snippet view article find links to article
cell disease occurs when a person inherits two abnormal copies of the β-globin gene (HBB) that makes haemoglobin, one from each parent. This gene occurs
Interspersed repeat (535 words) [view diff] exact match in snippet view article find links to article
organization L1Base Schimenti JC, Duncan CH (February 1984). "Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats". Nucleic
William French Anderson (4,067 words) [view diff] exact match in snippet view article find links to article
produce normal human globin from normal human mRNA, sickle cell globin from sickle cell mRNA, and the abnormal alpha/beta globin chain abnormality of
Heinz body (928 words) [view diff] exact match in snippet view article find links to article
complete defects in alpha globin production, leading to a relative abundance of beta globin chains in the cell. These excess beta globin chains aggregate to
KLF8 (592 words) [view diff] exact match in snippet view article find links to article
Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018
Douglas Higgs (964 words) [view diff] exact match in snippet view article find links to article
University of Oxford. He is known for his work on the regulation of alpha-globin and the genetics of alpha-thalassemia. He is currently working in understanding
Hemoglobin H disease (936 words) [view diff] exact match in snippet view article find links to article
out of 4 of the α-globin genes. Hemoglobin H disease is a genetic disorder resulting in absent or impaired production of the α-globin protein, a normal
Betibeglogene autotemcel (1,436 words) [view diff] exact match in snippet view article find links to article
Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral βΑ-T87Q -Globin Vector (LentiGlobin BB305 Drug Product)". Blood. 124 (21): 549. doi:10.1182/blood
Hemopexin (2,562 words) [view diff] exact match in snippet view article find links to article
met-hemoglobin which then further disassociates into free heme along with globin chain. The free heme will then be oxidized into free met-heme and sooner
Hemoglobin O (1,419 words) [view diff] exact match in snippet view article find links to article
Since the amino acid substitution can occur at different positions of the β-globin chain of the protein, there are several variants. In hemoglobin O-Arab (HbO-Arab)
OR52A1 (427 words) [view diff] exact match in snippet view article find links to article
1999). "An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells". Genomics. 61 (1): 15–23
Plasmepsin (438 words) [view diff] exact match in snippet view article find links to article
cleave hemoglobin between residues Phenylalanine 33 and Leucine 34 of α-globin subunit. The name plasmepsin may come from Plasmodium (the organism) and
Sickle cell-beta thalassemia (341 words) [view diff] exact match in snippet view article find links to article
from the other. A sickle allele is always the same mutation of the beta-globin gene (glutamic acid to valine at amino acid six). In contrast, beta-thalassemia
PCBP1 (1,155 words) [view diff] exact match in snippet view article find links to article
part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. GRCh38: Ensembl release 89: ENSG00000169564
Hemoglobin Constant Spring (146 words) [view diff] exact match in snippet view article find links to article
a variant of hemoglobin in which a mutation in the alpha globin gene produces an alpha globin chain that is abnormally long. It is the most common nondeletional
Unequal crossing over (877 words) [view diff] exact match in snippet view article find links to article
beta-globin genes are a response to deleterious selection from unequal crossing over in the beta-globin genes. Comparisons between alpha-globin, which
Hemoglobin J (133 words) [view diff] exact match in snippet view article find links to article
Hemoglobin J is an abnormal hemoglobin, an alpha globin gene variant and present in various geographic locations. It was first reported in a black American
TSPAN3 (476 words) [view diff] exact match in snippet view article find links to article
(1991). "Activation of globin gene expression by cDNAs from induced K562 cells. Evidence for involvement of ferritin in globin gene expression". J. Biol
Allelic heterogeneity (463 words) [view diff] exact match in snippet view article find links to article
example, β-thalassemia may be caused by several different mutations in the β-globin gene. Allelic heterogeneity should not be confused with locus heterogeneity
Management of thalassemia (4,028 words) [view diff] no match in snippet view article find links to article
Treatment of the inherited blood disorder thalassemia depends upon the level of severity. For mild forms of the condition, advice and counseling are often
Kruppel-like factors (2,233 words) [view diff] exact match in snippet view article find links to article
associated with de-repression of the fetal globin gene. KLF2 (originally Lung KLF ) also has a role in embryonic globin gene expression, as does KLF3 (originally
Orthology (107 words) [view diff] exact match in snippet view article find links to article
(homolog e.g. all globin protein), which are separated from each other after a speciation event, e.g. human beta and chimp beta globin. An orthologous gene
HOXB2 (940 words) [view diff] exact match in snippet view article find links to article
Heller P, DeSimone J (Aug 1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences
Robert Williamson (geneticist) (1,687 words) [view diff] exact match in snippet view article
globin genes and the thalassaemias. In 1974, Williamson's group demonstrated that severe alpha-thalassaemia is due to a deletion in the alpha globin gene
Haig Kazazian (2,362 words) [view diff] exact match in snippet view article find links to article
implications for the human blood disorder β-thalassemia. Using information on β-globin DNA polymorphisms from Stylianos Antonarakis and others, Kazazian helped
PCBP2 (1,285 words) [view diff] exact match in snippet view article find links to article
part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA
Allele-specific oligonucleotide (1,292 words) [view diff] exact match in snippet view article find links to article
and Wallace RB "Discrimination among the human beta A, beta S, and beta C-globin genes using allele-specific oligonucleotide hybridization probes." Am J
Gene cluster (1,918 words) [view diff] exact match in snippet view article find links to article
divergence. These gene clusters include the Hox gene cluster, the human β-globin gene cluster, and four clustered human growth hormone (hGH)/chorionic somatomammotropin
Francisco Ernesto Baralle (1,529 words) [view diff] exact match in snippet view article find links to article
for beta-globin, the first complete primary structure of a eukaryotic mRNA. In 1979, his research group isolated the gene for epsilon-globin (HBE1), a
Hemoglobin Hopkins-2 (2,644 words) [view diff] exact match in snippet view article find links to article
1177/1932296814538774. PMC 4455477. PMID 25355712. "N-Baltimore.html". globin.bx.psu.edu. Retrieved 2017-03-30. "Medical Archives - Personal Paper Collections:
BACH1 (1,169 words) [view diff] exact match in snippet view article find links to article
Taketani S (Feb 2004). "Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid
Nancy Haigwood (338 words) [view diff] exact match in snippet view article find links to article
titled The organization of repetitive sequences in two cloned mouse beta-globin clusters. Haigwood completed a postdoctoral fellowship at Johns Hopkins
Klenow fragment (473 words) [view diff] exact match in snippet view article find links to article
PMC 286206. PMID 4905667. Saiki RK, et al. (1985). "Enzymatic Amplification of β-globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle
OR52A5 (299 words) [view diff] exact match in snippet view article find links to article
analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. Bibcode:2000PNAS
OR51V1 (277 words) [view diff] exact match in snippet view article find links to article
analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. Bibcode:2000PNAS
Hemoglobin D-Punjab (743 words) [view diff] exact match in snippet view article find links to article
hemoglobin variant. It originates from a point mutation in the human β-globin locus and is one of the most common hemoglobin variants worldwide. It is
KLF13 (1,473 words) [view diff] exact match in snippet view article find links to article
2000). "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes". Blood. 95 (11): 3578–84. doi:10.1182/blood
ATR-X syndrome (1,149 words) [view diff] exact match in snippet view article find links to article
expression of alpha-globin gene cluster, causing alpha-thalassemia." ATRX interacts with the transcription co-factor DAXX and the alpha-globin gene cluster.
GATA1 (5,512 words) [view diff] exact match in snippet view article find links to article
1620/tjem.242.83. PMID 28566565. "Entrez Gene: GATA1 GATA binding protein 1 (globin transcription factor 1)". Da Costa L, O'Donohue MF, van Dooijeweert B, Albrecht
Griffin P. Rodgers (626 words) [view diff] exact match in snippet view article find links to article
erythrocytes (peripheral blood CD34+ cells), the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII
Microcytic anemia (1,705 words) [view diff] exact match in snippet view article find links to article
inherited condition that has variants in alpha or beta globin genes that result in lower levels of globin chains required to make hemoglobin, resulting in alpha
TSPYL1 (453 words) [view diff] exact match in snippet view article find links to article
"Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster". Blood Cells Mol
Alstonia macrophylla (667 words) [view diff] exact match in snippet view article find links to article
asianplant.net/Apocynaceae/Alstonia_macrophylla.htm Alstonia macrophylla at Globin-Med at http://www.globinmed.com/index.php?option=com_content&view=artic
Mi-2/NuRD complex (1,064 words) [view diff] exact match in snippet view article find links to article
cells, in which CHD4 but not Mi-2 is required for suppression of fetal globin genes. NuRD is traditionally thought of as a primarily repressive complex
CAG promoter (444 words) [view diff] exact match in snippet view article find links to article
of chicken beta-actin gene, (G) the splice acceptor of the rabbit beta-globin gene The resulting synthetic element was used in the pCAGGS expression vector
RHBDF1 (527 words) [view diff] exact match in snippet view article find links to article
a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse". Mamm Genome
CAP1 (857 words) [view diff] exact match in snippet view article find links to article
interactions of CAP+1 (A-->C), a silent beta-globin gene mutation, with other beta-thalassemia mutations and globin gene modifiers in north Indians". Eur. J
Ecogenetics (462 words) [view diff] exact match in snippet view article find links to article
abnormal hemoglobin, inability to manufacture one or the other of the peptide globin chains of the hemoglobin, and deficiencies of the Embden-Meyerhoff monophosphate
Richard C. Mulligan (656 words) [view diff] exact match in snippet view article find links to article
(January 1979). "Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome". Nature. 277 (5692):
Russel Kaufman (653 words) [view diff] exact match in snippet view article find links to article
research, some of Kaufman's discoveries include the characterization of the β-globin genes and the discovery of the CD7 ligand, K12. Additionally, he has focused
Maqsudul Alam (1,251 words) [view diff] exact match in snippet view article find links to article
Alam. Synteny and Collinearity in Plant Genomes (2008). Protoglobin and globin-coupled sensors (2008). "About Professor Maqsudul Alam". Basic & Applied
List of drugs: G (643 words) [view diff] exact match in snippet view article find links to article
glisentide (INN) glisindamide (INN) glisolamide (INN) glisoxepide (INN) globin zinc insulin injection (INN) Glofil-125 glofitamab (INN) gloxazone (INN)
Philip Leder (584 words) [view diff] exact match in snippet view article find links to article
defined the base sequence of a complete mammalian gene (the gene for beta globin), which enabled him to determine its organization in detail, including its
ZHX2 (545 words) [view diff] exact match in snippet view article find links to article
"Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster". Blood Cells Mol
Chionodraco rastrospinosus (895 words) [view diff] exact match in snippet view article find links to article
fail to express the major adult α-globin, α1, due to the same 5' truncation of the gene, and have lost the β-globin gene entirely. Zhao et al. propose
Bryant Villeponteau (1,940 words) [view diff] exact match in snippet view article find links to article
Biochemistry from 1978 to 1980, where he carried out genomic cloning of the B-globin gene cluster in Chickens.... He continued in the same department for six
MAFK (2,536 words) [view diff] exact match in snippet view article find links to article
complex binding to a specific motif (NF-E2) in the regulatory regions of β-globin and other erythroid-related genes. MAFK has been identified in many vertebrates
Oligomer restriction (1,020 words) [view diff] exact match in snippet view article find links to article
Erlich HA; Arnheim N (20 December 1985). "Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle
Michel Sadelain (2,364 words) [view diff] exact match in snippet view article find links to article
Therapeutics Inc. Sadelain also designed lentiviral vectors encoding the β-globin gene for the treatment of severe hemoglobinopathies, which include β-thalassemia
Wei-Shau Hu (559 words) [view diff] exact match in snippet view article find links to article
titled Homologous DNA recombination in primate cells of human adult alpha globin gene duplication units. She studied the mechanisms of DNA recombination
CTCF (3,172 words) [view diff] exact match in snippet view article find links to article
sequences. This model has been demonstrated by the previous work on the beta-globin locus. The binding of CTCF has been shown to have many effects, which are
Composite transposon (250 words) [view diff] exact match in snippet view article find links to article
This was reported for a 710 bp DNA sequence upstream of the bovine beta globin gene. The DNA arrangement forms a composite transposon whose presence has
Harold M. Weintraub (2,137 words) [view diff] exact match in snippet view article find links to article
Groudine, M; Weintraub, H (1975). "Rous sarcoma virus activates embryonic globin genes in chick fibroblasts". Proc Natl Acad Sci USA. 72 (11): 4464–4468
Structure specific recognition protein 1 (1,118 words) [view diff] exact match in snippet view article find links to article
SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene". Mol. Cell. Biol. 18 (5): 2617–28. doi:10.1128/MCB.18.5.2617. PMC 110641
Agnès Bernet (578 words) [view diff] exact match in snippet view article find links to article
human alpha globin genes). Her research focused on the study of two regions that may be involved in the activation of human alpha globin genes during
Virginia Barbour (755 words) [view diff] exact match in snippet view article find links to article
University of Oxford where her research investigated the control of alpha globin genes and was awarded in 1997. Following her education and training, Barbour
Virginia Barbour (755 words) [view diff] exact match in snippet view article find links to article
University of Oxford where her research investigated the control of alpha globin genes and was awarded in 1997. Following her education and training, Barbour
Keratin 7 (1,172 words) [view diff] exact match in snippet view article find links to article
papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7". Journal of Virology. 76 (14): 7040–8. doi:10.1128/JVI
James E. Bowman (1,356 words) [view diff] exact match in snippet view article find links to article
Globin Loci. Proceedings of the Fourth Annual Comprehensive Sickle Cell Center Symposium on the Distribution and Evolution of Hemoglobin and Globin Loci
Intron (5,839 words) [view diff] exact match in snippet view article find links to article
Kinniburgh AJ, Mertz JE, Ross J (July 1978). "The precursor of mouse beta-globin messenger RNA contains two intervening RNA sequences". Cell. 14 (3): 681–693
Hydrops fetalis (1,673 words) [view diff] exact match in snippet view article find links to article
can also cause hydrops fetalis when all four of the genetic loci for α globin are deleted or affected by mutation. This is termed Hb Barts (consists of
Bluebird bio (1,348 words) [view diff] exact match in snippet view article find links to article
second most expensive drug in the world. The company is developing LentiGlobin gene therapy for the treatment of sickle cell disease and cerebral adrenoleukodystrophy
EIF2AK1 (1,113 words) [view diff] exact match in snippet view article find links to article
synthesis ensuring a coordinated regulation of the synthesis of the heme and globin moieties of hemoglobin. Thus plays an essential protective role for RBC
Henry I. Miller (1,485 words) [view diff] exact match in snippet view article find links to article
intervening sequence of the mouse beta-major globin gene shares extensive homology only with beta-globin genes". Nature. 275 (5682): 772–774. doi:10.1038/275772a0
Nonsense-mediated decay (2,900 words) [view diff] exact match in snippet view article find links to article
region of the β-globin gene. An individual carrying only one affected allele will have no or extremely low levels of the mutant β-globin mRNA. An even more
Chromosome 11 (1,930 words) [view diff] exact match in snippet view article find links to article
syndrome Mantle cell lymphoma (t11;14) Meckel syndrome methemoglobinemia, beta-globin type Mixed lineage leukemia multiple endocrine neoplasia type 1 Hereditary
Testicular receptor 2 (925 words) [view diff] exact match in snippet view article find links to article
Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO
NPRL3 (648 words) [view diff] exact match in snippet view article find links to article
gene is highly conserved in vertebrates which is upstream from the alpha globin gene cluster. Within the fifth intron of the gene there is a regulatory
Genetically modified mouse (1,707 words) [view diff] exact match in snippet view article find links to article
PMID 6272397. Costantini, F.; Lacy, E. (1981). "Introduction of a rabbit β-globin gene into the mouse germ line". Nature. 294 (5836): 92–4. Bibcode:1981Natur
KLF3 (1,303 words) [view diff] exact match in snippet view article find links to article
Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". Mol. Cell. Biol. 33 (15): 2976–87. doi:10.1128/MCB.00074-13
Restriction fragment length polymorphism (1,159 words) [view diff] exact match in snippet view article find links to article
Horn, G.; Erlich, H.; Arnheim, N (1985). "Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle
Pleiotropy (4,796 words) [view diff] exact match in snippet view article find links to article
mutation in the HBB gene. The HBB gene encodes information to make the beta-globin subunit of hemoglobin, which is the protein red blood cells use to carry
List of Heroes of the Soviet Union (G) (2,386 words) [view diff] exact match in snippet view article
Glinka Dmitry Glinka (twice) Sergey Glinkin Sergey Glinsky (ru) Nikolai Globin (ru) Nikolai Glotov (ru) Ivan Glukhikh (ru) Dmitry Glukhov (ru) Ivan Glukhov
Testicular receptor 4 (1,137 words) [view diff] exact match in snippet view article find links to article
Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO
Tom Maniatis (1,883 words) [view diff] exact match in snippet view article find links to article
Maniatis lab isolated and characterized the entire “cluster” of human b-globin genes, which were the first human genes to be cloned and their DNA sequences
SOX6 (1,166 words) [view diff] exact match in snippet view article find links to article
Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells
Marco Antonio Zago (1,014 words) [view diff] exact match in snippet view article find links to article
variants, including a point mutation in the promoter region of the gamma globin gene responsible for the Brazilian form of HbF persistence. Identified molecular
USF1 (4,538 words) [view diff] exact match in snippet view article find links to article
silencing modifications from the 16 kb heterochromatic domain into the β-globin locus. Moreover, USF1 and USF2 can bind to the 5' DNase I hypersensitive
Heterochromatin (2,184 words) [view diff] exact match in snippet view article find links to article
genes are juxtaposed (e.g. the 5'HS4 insulator upstream of the chicken β-globin locus, and loci in two Saccharomyces spp.). All cells of a given species
Kary Mullis (4,851 words) [view diff] exact match in snippet view article find links to article
Mullis's 1985 paper with Saiki and Erlich, "Enzymatic Amplification of β-globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle
Taq polymerase (2,604 words) [view diff] exact match in snippet view article find links to article
Erlich HA, Arnheim N (December 1985). "Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle
HMGB2 (1,190 words) [view diff] exact match in snippet view article find links to article
protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster". Biochemistry and Cell Biology. 80 (6): 765–70. doi:10.1139/o02-164
NFE2L3 (1,547 words) [view diff] exact match in snippet view article find links to article
LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression". Nucleic Acids Research. 22 (12): 2383–91. doi:10.1093/nar/22
Transporter Classification Database (5,159 words) [view diff] exact match in snippet view article find links to article
Load-activated Calcium Channel (CLAC) Family 1.A.107 The Pore-forming Globin (Globin) Family 1.B.1 General bacterial porin family 1.B.2 Chlamydial porin
Stem cell lineage database (2,065 words) [view diff] exact match in snippet view article find links to article
alpha-globin genes in place of mouse alpha-globin genes, and they replaced the beta-globin genes of the mouse with sickle cell effected human beta-globin genes
Sickle Cell Anemia, a Molecular Disease (996 words) [view diff] exact match in snippet view article find links to article
and Itano's first publication on the disease. Itano also found that the globin portion of sickle cell hemoglobin had a barely detectable difference in
ARID1A (1,792 words) [view diff] exact match in snippet view article find links to article
AT-rich DNA sequence known to be recognized by a SWI/SNF complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid
Mir-210 microRNA (1,903 words) [view diff] exact match in snippet view article find links to article
"Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression". BMB Reports. 42 (8): 493–499. doi:10.5483/BMBRep.2009
Kupffer cell (1,861 words) [view diff] exact match in snippet view article find links to article
by destroying senescent red blood cells through phagocytic action. The globin chains are re-used, while the iron-containing portion, heme, is further
Nuclear organization (4,188 words) [view diff] exact match in snippet view article find links to article
These hubs were discovered during observation of activated alpha- and beta-globin loci. ACHs are formed through extensive DNA looping to form a "hub" of regulatory
Virginia Minnich (1,754 words) [view diff] exact match in snippet view article find links to article
caused by a mutation in the β-globin gene (HBB). People who inherit one copy of the HbE gene and one copy of the normal β-globin gene (HbA) are said to "carry
Umbellulone (1,208 words) [view diff] exact match in snippet view article find links to article
Umbellulone induces rapid production of methemoglobine. Methemoglobine is a globin in the blood that mainly consists of ferric (Fe3+) haemoglobin, instead
Porphobilinogen deaminase (1,617 words) [view diff] exact match in snippet view article find links to article
(1989). "A 5' splice-region G----C mutation in exon 1 of the human beta-globin gene inhibits pre-mRNA splicing: a mechanism for beta+-thalassemia". Proc
CUTL1 (1,848 words) [view diff] exact match in snippet view article find links to article
Nicolis S, Ronchi A, Giglioni B (1990). "DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobin"
INHA (1,000 words) [view diff] exact match in snippet view article find links to article
AL, Yu AL, Mathews LS, Vaughan J, et al. (1992). "Effect of activin A on globin gene expression in purified human erythroid progenitors". Blood. 79 (3):
Human genome (10,152 words) [view diff] exact match in snippet view article find links to article
Grosveld F (1984). "DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells". Cell. 38 (1): 265–273. doi:10
Yellow-billed pintail (959 words) [view diff] exact match in snippet view article find links to article
lower-altitude populations, which can be attributable to substitutions in their beta-globin gene. These substitutions are shared by speckled teal because of introgressive
Erythropoiesis (1,770 words) [view diff] exact match in snippet view article find links to article
ISBN 9780323034104. Erythropoiesis Heme synthesis is coordinated with globin synthesis during erythropoiesis and as such does not occur in the mature
Y box binding protein 1 (1,682 words) [view diff] exact match in snippet view article find links to article
shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes". The Journal of Biological Chemistry. 269 (19): 14130–14139. doi:10
MAFF (gene) (1,840 words) [view diff] exact match in snippet view article
site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation". Blood Cells, Molecules & Diseases. 29 (2): 145–58
Hydroxycarbamide (1,797 words) [view diff] exact match in snippet view article find links to article
activation with a resultant rise in cyclic GMP, and the activation of gamma globin gene expression and subsequent gamma chain synthesis necessary for fetal
Merlin Crossley (1,408 words) [view diff] exact match in snippet view article find links to article
for post-pubertal recovery. He has also investigated abnormal patterns of globin gene expression and his work on mutations associated with the lifelong expression
Richard M. Myers (1,510 words) [view diff] exact match in snippet view article find links to article
University of California in San Francisco. His team sought to understand globin gene expression, studying both cis- and trans-acting components that regulate
Mike Inez (1,315 words) [view diff] exact match in snippet view article find links to article
Year Title Role Notes 1995 The Nona Tapes Himself Short film 2013 AIC 23 Unta Gleeben Glabben Globben Globin Short film
Genetics (10,398 words) [view diff] exact match in snippet view article find links to article
results from a single base difference within the coding region for the β-globin section of hemoglobin, causing a single amino acid change that changes hemoglobin's
Intravascular hemolysis (1,034 words) [view diff] exact match in snippet view article find links to article
met-hemoglobin (ferric hemoglobin). In such conditions, heme along with globin chains can be released from further oxidization of met-hemoglobin (ferric
James V. Neel (1,912 words) [view diff] exact match in snippet view article find links to article
responsible for providing instructions for the creation of the protein β-globin. When this mutation occurs, red blood cells transform into a rigid, "sickle"
Gene therapy (17,856 words) [view diff] exact match in snippet view article find links to article
transfusions. The technique used a lentiviral vector to transduce the human β-globin gene into purified blood and marrow cells obtained from the patient in June
Super-enhancer (4,359 words) [view diff] exact match in snippet view article find links to article
Banerji J, Rusconi S, Schaffner W (December 1981). "Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences". Cell. 27 (2 Pt 1): 299–308
Kiyoshi Nagai (1,175 words) [view diff] exact match in snippet view article find links to article
PMID 29377672. Nagai, K.; Thøgersen, H. C. (1984). "Generation of beta-globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia
Expressivity (genetics) (1,735 words) [view diff] exact match in snippet view article
presence of alpha-thalassemia, a genetic blood disease in which the alpha globin subunit of the hemoglobin protein is underproduced, are thought to be major
TEX9 (1,202 words) [view diff] exact match in snippet view article find links to article
rate of change for TEX9 is fairly slow compared to fibrinogen and beta-globin, but not as slow as cytochrome c. TEX9 sequences that are most conserved
Epigenomics (5,663 words) [view diff] exact match in snippet view article find links to article
and hemoglobin gene loci. Different regions of the gene (gamma delta beta globin) were known to be expressed at different stages of development. Consistent
Compound heterozygosity (1,243 words) [view diff] exact match in snippet view article find links to article
sickle cell gene in a compound heterozygous manner with other mutant beta globin genes. These disorders include sickle cell-beta thalassemia. In the case
INHBA (1,109 words) [view diff] exact match in snippet view article find links to article
S2CID 24201803. Shao L, Frigon NL, Young AL, et al. (1992). "Effect of activin A on globin gene expression in purified human erythroid progenitors". Blood. 79 (3):
GATA4 (2,325 words) [view diff] exact match in snippet view article find links to article
DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes". Proc. Natl. Acad. Sci. U.S.A. 85 (16): 5976–80. Bibcode:1988PNAS
SV40 (2,245 words) [view diff] exact match in snippet view article find links to article
Banerji, J; Rusconi, S; Schaffner, W (December 1981). "Expression of a β-globin gene is enhanced by remote SV40 DNA sequences". Cell. 27 (2): 299–308. doi:10
White Amazonian Indians (790 words) [view diff] exact match in snippet view article find links to article
Maria S.; Costa, Fernando F.; Sonati, Maria F. (2003). "Haplotypes of alpha-globin gene regulatory element in two Brazilian native populations". American Journal
Dominance (genetics) (2,496 words) [view diff] exact match in snippet view article
said to be co-dominant. Another example occurs at the locus for the beta-globin component of hemoglobin, where the three molecular phenotypes of HbA/HbA
Coboglobin (154 words) [view diff] exact match in snippet view article find links to article
April 2000). "Modulation of the Oxygen Affinity of Cobalt-Porphyrin by Globin". FEBS Letters. 472 (2–3): 221–224. doi:10.1016/S0014-5793(00)01423-X.
Planorbidae (2,314 words) [view diff] exact match in snippet view article find links to article
mechanism to create a high molecular mass respiratory protein from 78 similar globin domains. Albrecht C., Kuhn K. & Streit B. (2007). "A molecular phylogeny
MAFG (2,631 words) [view diff] exact match in snippet view article find links to article
1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". Blood. 89 (11): 3925–35. doi:10.1182/blood.V89.11.3925
Polymerase chain reaction (11,117 words) [view diff] exact match in snippet view article find links to article
paper with R. K. Saiki and H. A. Erlich, "Enzymatic Amplification of β-globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle
Charles Daniel Lane (1,864 words) [view diff] exact match in snippet view article find links to article
reference of the Nature paper. The key role of Gerard Marbaix (who prepared the globin mRNA) is apparent from the landmark paper. A vital question was the extent
John Barnabas (1,032 words) [view diff] exact match in snippet view article find links to article
Barnabas; Morris Goodman; G. William Moore (1972). "Descent of Mammalian Alpha Globin Chain Sequences Investigated by the Maximum Parsimony Method". Journal of
Butera (1,465 words) [view diff] exact match in snippet view article find links to article
of Mississippi. pp. 35–36. ISBN 9781604737578. "Presence of an African β-globin gene cluster haplotype in normal chromosomes in sicily - ResearchGate".
RBP3 (1,732 words) [view diff] exact match in snippet view article find links to article
primates) based on two unlinked nuclear genes: IRBP intron 1 and epsilon-globin sequences". American Journal of Physical Anthropology. 100 (2): 153–79.
Sickle cell retinopathy (2,209 words) [view diff] exact match in snippet view article find links to article
disc vessels. Normal adult hemoglobin A molecule comprises two α and two β globin chains associated with a heme ring. Mutation at the 6th position of the
LUC7L (501 words) [view diff] exact match in snippet view article find links to article
(LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain". Genomics. 71 (3): 307–14. doi:10.1006/geno.2000.6394. PMID 11170747
DNA-3-methyladenine glycosylase (2,589 words) [view diff] exact match in snippet view article find links to article
a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse". Mammalian
Plasmodium silvaticum (271 words) [view diff] exact match in snippet view article find links to article
Kilbourn AM, Bosi EJ, Ruvolo M. (2005) The population genetics of the alpha-2 globin locus of orangutans (Pongo pygmaeus) J. Mol. Evol. 60(3):400-408 v t e
History of polymerase chain reaction (3,101 words) [view diff] exact match in snippet view article find links to article
Retrieved 8 February 2024. Saiki RK et al. "Enzymatic Amplification of β-globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle
Alfred Mirsky (969 words) [view diff] exact match in snippet view article find links to article
"Protein Coagulation and its Reversal: The Preparation of Insoluble Globin, Soluble Globin and Heme", Journal of General Physiology, 13, 469–476. Mirsky AE
Haptoglobin (2,863 words) [view diff] exact match in snippet view article find links to article
Hb-Hp binding to CD163, cellular internalization of the complex leads to globin and heme metabolism, which is followed by adaptive changes in antioxidant
Heme oxygenase (3,774 words) [view diff] exact match in snippet view article find links to article
the name "haemoglobin"; haem being derived from Greek meaning blood, and globin from Latin globus meaning round object (see also: carboxyhemoglobin etymology)
Kozak consensus sequence (3,629 words) [view diff] exact match in snippet view article find links to article
Research has shown that a mutation of G—>C in the −6 position of the β-globin gene (β+45; human) disrupted the haematological and biosynthetic phenotype
Rumen (3,131 words) [view diff] exact match in snippet view article find links to article
(1991-09-01). "5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells". Molecular and Cellular Biology
Conservation genetics (3,039 words) [view diff] exact match in snippet view article find links to article
fitness of homozygotes, the textbook example being the sickle-cell beta-globin allele, which is maintained at high frequencies in populations where malaria
Genetic disorder (3,579 words) [view diff] exact match in snippet view article find links to article
PMC 1684820. PMID 3717163. Weatherall DJ (2015). "The Thalassemias: Disorders of Globin Synthesis". Williams Hematology (9e ed.). McGraw Hill Professional. p. 725
Polycythemia (3,296 words) [view diff] exact match in snippet view article find links to article
genetic testing, if high suspicion for familial erythrocytosis Hemoglobin (globin-gene) sequencing or high-performance liquid chromatography to evaluate for
Conservation genetics (3,039 words) [view diff] exact match in snippet view article find links to article
fitness of homozygotes, the textbook example being the sickle-cell beta-globin allele, which is maintained at high frequencies in populations where malaria
LUC7L (501 words) [view diff] exact match in snippet view article find links to article
(LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain". Genomics. 71 (3): 307–14. doi:10.1006/geno.2000.6394. PMID 11170747
Functional divergence (614 words) [view diff] exact match in snippet view article find links to article
Hideaki (March 2008). "Adaptive Functional Divergence Among Triplicated α-Globin Genes in Rodents". Genetics. 178 (3): 1623–1638. doi:10.1534/genetics.107
Riftia (6,309 words) [view diff] exact match in snippet view article find links to article
is bright red due to the presence of hemoglobin that contain up to 144 globin chains (each presumably including associated heme structures). These tube
Nonsense mutation (2,870 words) [view diff] exact match in snippet view article find links to article
fibrosis transmembrane conductance regulator (CFTR) Beta thalassaemia (β-globin) Hurler syndrome Dravet syndrome Usher syndrome Nonsense mutations in other
Aye-aye (3,560 words) [view diff] exact match in snippet view article find links to article
Schneider, M.P.C.; et al. (1995). "Evidence on primate phylogeny from ε-globin gene sequences and flanking regions". Journal of Molecular Evolution. 40
Hemosiderosis (1,299 words) [view diff] exact match in snippet view article find links to article
Maggioni, Marco; Fracanzani, Anna Ludovica; Fargion, Silvia (2010). "Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients
NFE2L2 (3,402 words) [view diff] exact match in snippet view article find links to article
transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region". Proceedings of the National Academy of Sciences of
RNA splicing (4,480 words) [view diff] exact match in snippet view article find links to article
Frede U, Hentze MW, Kulozik AE (March 2002). "Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive
Hepcidin (2,393 words) [view diff] exact match in snippet view article find links to article
most common congenital anemias, arises from partial or complete lack of β-globin synthesis. Excessive iron absorption is one of the main features of β-thalassemia
Oral manifestations of systemic disease (2,142 words) [view diff] exact match in snippet view article find links to article
the haemoglobin synthesis; it can result in either a reduced or absent globin chain production. If beta thalassaemia major is left untreated or under
The Ancestor's Tale (977 words) [view diff] exact match in snippet view article find links to article
haemoglobin genes are known to be cousin genes of each other. An ancestor globin gene from an ancient vertebrate split into two genes, alpha and beta, which
Site-directed mutagenesis (2,980 words) [view diff] exact match in snippet view article find links to article
"Site-directed mutagenesis in DNA: Generation of point mutations in cloned β globin complementary DNA at the positions corresponding to amino acids 121 to 123"
PCBP3 (540 words) [view diff] exact match in snippet view article find links to article
Liebhaber SA (1995). "Identification of two KH domain proteins in the alpha-globin mRNP stability complex". EMBO J. 14 (17): 4357–64. doi:10.1002/j.1460-2075
Buchanan Medal (1,081 words) [view diff] exact match in snippet view article find links to article
Douglas Higgs "for his seminal work on the regulation of the human alpha-globin gene cluster and the role of the ATRX protein in genetic disease" 2015 Irwin
Blood (6,555 words) [view diff] exact match in snippet view article find links to article
as oxygen. Instead, it combines with the N-terminal groups on the four globin chains. However, because of allosteric effects on the hemoglobin molecule
HNRNPC (1,580 words) [view diff] exact match in snippet view article find links to article
mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP
Messenger RNA (5,922 words) [view diff] exact match in snippet view article find links to article
analysis of an mRNP complex that mediates the high stability of human beta-globin mRNA". Molecular and Cellular Biology. 21 (17): 5879–5888. doi:10.1128/mcb
Gene conversion (3,004 words) [view diff] exact match in snippet view article find links to article
they exhibit biased directionality. Sometimes, such as in case of human globin genes (Papadakis and Patrinos, 1999), the gene conversion direction correlates
Ralph L. Brinster (3,974 words) [view diff] exact match in snippet view article find links to article
L., Chen, H. Y., Trumbauer, M. E., and Avarbock, M. R. Translation of globin messenger RNA by the mouse ovum. Nature. 1980; 283: 499-501. Brinster, R
Eastern deer mouse (2,705 words) [view diff] exact match in snippet view article find links to article
the α-chain subunits of adult hemoglobin. Modifications in the α and β globin genes may also indicate an increase in hemoglobin-oxygen affinity and oxygen
Human germline engineering (6,767 words) [view diff] exact match in snippet view article find links to article
researchers attempted to edit the HBB gene which codes for the human β-globin protein. Mutations in the HBB gene result in the disorder β-thalassaemia
ERAF (580 words) [view diff] exact match in snippet view article find links to article
Y, Eaton SA, et al. (2002). "Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein". J. Biol. Chem. 277
HNRPD (1,472 words) [view diff] exact match in snippet view article find links to article
(heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex". Mol. Cell. Biol. 17 (8): 4870–6. doi:10.1128/MCB
Transcription factor Sp1 (3,444 words) [view diff] exact match in snippet view article find links to article
A, Collins FS (October 1991). "Interaction of Sp1 with the human gamma globin promoter: binding and transactivation of normal and mutant promoters". Blood
Neonatal jaundice (3,247 words) [view diff] exact match in snippet view article find links to article
also called Morbus Günther; Uroporphyrinogen III Synthase deficiency) Globin synthesis defect sickle cell disease Alpha-thalassemia, e.g. HbH disease
Fotis Kafatos (1,197 words) [view diff] exact match in snippet view article find links to article
C.; Maxam, A. M.; Maniatis, T. (1976). "Enzymatic in vitro synthesis of globin genes". Cell. 7 (2): 279–288. doi:10.1016/0092-8674(76)90027-1. PMID 60178
Colworth Medal (1,714 words) [view diff] exact match in snippet view article find links to article
119–26. doi:10.1042/bst0110119. PMID 6420211. Flavell, R. A. (1983). "The globin genes of rabbit and man. The eighteenth Colworth medal lecture". Biochemical
Mark T. Gladwin (1,565 words) [view diff] exact match in snippet view article find links to article
monoxide poisoning. He currently serves as Chair of the Board of Directors of Globin Solutions, Inc., a pre-clinical stage biopharmaceutical company researching
Channichthyidae (3,117 words) [view diff] exact match in snippet view article find links to article
S2CID 3261779. Cocca, E (1997). "Do the hemoglobinless icefishes have globin genes?". Comp. Biochem. Physiol. A. 118 (4): 1027–1030. doi:10.1016/s0300-9629(97)00010-8
History of molecular evolution (4,139 words) [view diff] exact match in snippet view article find links to article
phylogeny, but also the hypothesis (first proposed in 1957) that the different globin chains within a single organism could also be traced to a common ancestral
Red blood cell (7,850 words) [view diff] exact match in snippet view article find links to article
to carbon dioxide transport is that carbon dioxide directly reacts with globin protein components of hemoglobin to form carbaminohemoglobin compounds.
Splice site mutation (1,719 words) [view diff] exact match in snippet view article find links to article
mutations. For example, mutations that cause the incorrect splicing of β-globin mRNA are responsible of some cases of β-thalassemia. Another Example is
NFE2L1 (3,657 words) [view diff] exact match in snippet view article find links to article
LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression". Nucleic Acids Research. 22 (12): 2383–91. doi:10.1093/nar/22
Transcription activator-like effector nuclease (3,147 words) [view diff] exact match in snippet view article find links to article
beneficial naturally occurring mutation associated with increased fetal globin". Nature Communications. 6: 7085. Bibcode:2015NatCo...6.7085W. doi:10.1038/ncomms8085
H. Franklin Bunn (597 words) [view diff] exact match in snippet view article find links to article
component HbA1c contains glucose attached to the N-terminus of the beta globin chain by a ketosamine linkage, providing the rationale for measurement of
Ezo salamander (1,940 words) [view diff] exact match in snippet view article find links to article
M. (2000-03-17). "Erythropoiesis and unexpected expression pattern of globin genes in the salamander Hynobius retardatus". Development Genes and Evolution
SMARCD1 (970 words) [view diff] exact match in snippet view article find links to article
binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 349–54. Bibcode:1999PNAS
Long interspersed nuclear element (2,765 words) [view diff] exact match in snippet view article find links to article
long reiterated DNA sequences, one copy of which is next to the human beta globin gene". Nucleic Acids Research. 8 (24): 6113–6128. doi:10.1093/nar/8.24.6113
CRISPR gene editing (17,442 words) [view diff] exact match in snippet view article find links to article
Vakulskas CA, Bode NM, et al. (April 2021). "Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic
PCBP4 (682 words) [view diff] exact match in snippet view article find links to article
Liebhaber SA (1995). "Identification of two KH domain proteins in the alpha-globin mRNP stability complex". EMBO J. 14 (17): 4357–64. doi:10.1002/j.1460-2075
Hemoglobin-G (536 words) [view diff] exact match in snippet view article find links to article
(alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions". Proceedings of the National Academy of Sciences. 77 (11):
Phylogenetic footprinting (946 words) [view diff] exact match in snippet view article find links to article
M., Slightom, J. L., Hess, D., and Jones, R. T. 1988. Embryonic ε and γ globin genes of a prosimian primate (Galago crassicaudatis): nucleotide and amino
Serpula (3,629 words) [view diff] exact match in snippet view article find links to article
Negrisolo E, Barbato R, et al. (July 2001). "The primary structure of globin and linker chains from the chlorocruorin of the polychaete Sabella spallanzanii"
Duchenne muscular dystrophy (6,470 words) [view diff] exact match in snippet view article find links to article
Kirby S, Walsh CE, et al. (September 2002). "Restoration of human beta-globin gene expression in murine and human IVS2-654 thalassemic erythroid cells
New England Biolabs (2,213 words) [view diff] exact match in snippet view article find links to article
In October 2019, NEB released a new RNA depletion product, the NEBNext Globin & rRNA Depletion Kit (Human/Mouse/Rat) and NEBNext rRNA Depletion Kit (Bacteria)
New England Biolabs (2,213 words) [view diff] exact match in snippet view article find links to article
In October 2019, NEB released a new RNA depletion product, the NEBNext Globin & rRNA Depletion Kit (Human/Mouse/Rat) and NEBNext rRNA Depletion Kit (Bacteria)
Promoter (genetics) (6,286 words) [view diff] exact match in snippet view article
Kleihauer E (May 1991). "Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC
David Weatherall (1,268 words) [view diff] exact match in snippet view article find links to article
thalassemias that are associated with abnormalities in the production of globin, the protein component of haemoglobin. Weatherall was one of the world's
Shyam Swarup Agarwal (2,445 words) [view diff] exact match in snippet view article find links to article
NF-kB and RXR beta like proteins in interferon induced HLA class I and beta globin gene transcription in K562 erythroleukaemia cells". Molecular and Cellular
Harry Ostrer (1,058 words) [view diff] exact match in snippet view article find links to article
subsequently showed that this mutation altered the splicing of the encoded globin transcript, resulting in a mild thalassemia phenotype. At NYU, members of
Tsuneko Okazaki (1,230 words) [view diff] exact match in snippet view article find links to article
(March 2010). "Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster". Nucleic Acids Research. 38 (5): e33. doi:10.1093/nar/gkp1168
KIAA1143 (1,184 words) [view diff] exact match in snippet view article find links to article
rate of change for KIAA1143 is fairly slow compared to fibrinogen and beta-globin, but not as slow as cytochrome c. The DUF4604 domain in KIAA1143 is conserved
Chromatin target of prmt1 (363 words) [view diff] exact match in snippet view article find links to article
van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). "Fetal globin expression is regulated by Friend of Prmt1". Blood. 116 (20): 4349–52. doi:10
Carbon dioxide (13,088 words) [view diff] exact match in snippet view article find links to article
as oxygen. Instead, it combines with the N-terminal groups on the four globin chains. However, because of allosteric effects on the hemoglobin molecule
Yuet Wai Kan (3,604 words) [view diff] exact match in snippet view article find links to article
Andree M. (1978). "Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation" (PDF). Proceedings of
Alternative splicing (7,809 words) [view diff] exact match in snippet view article find links to article
Frede U, Hentze MW, Kulozik AE (March 2002). "Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive
Human genetic resistance to malaria (9,634 words) [view diff] exact match in snippet view article find links to article
HbS gene defect is a mutation of a single nucleotide (A to T) of the β-globin gene replacing the amino acid glutamic acid with the less polar amino acid
Digital polymerase chain reaction (7,294 words) [view diff] exact match in snippet view article find links to article
by Cetus Corporation when researchers showed that a single copy of the β-globin gene could be detected and amplified by PCR. This was achieved by diluting
Neutral mutation (3,417 words) [view diff] exact match in snippet view article find links to article
role of neutral mutations in evolution. The rates of mutation in mammalian globin pseudogenes has been shown to be much higher than rates in functional genes
MicroRNA 210 (686 words) [view diff] exact match in snippet view article find links to article
"Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression". BMB Rep. 42 (8): 493–9. doi:10.5483/bmbrep.2009.42.8.493
Gene targeting (4,387 words) [view diff] exact match in snippet view article find links to article
(September 1985). "Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination". Nature. 317 (6034): 230–234. doi:10
Nucleosome (6,714 words) [view diff] exact match in snippet view article find links to article
Felsenfeld G, Allan J (April 1994). "Nucleosome positioning on chicken and human globin gene promoters in vitro. Novel mapping techniques". Journal of Molecular
Michael Behe (6,301 words) [view diff] exact match in snippet view article find links to article
PMID 3754471. S2CID 44340223. —— (December 1987). "The DNA sequence of the human β-globin region is strongly biased in favor of long strings of contiguous purine
Vitamin C (15,120 words) [view diff] exact match in snippet view article find links to article
and evolution of selected primates as determined by sequences of the ε-globin locus and 5′ flanking regions". Int J Primatol. 18 (2): 261–95. doi:10
Molecular diagnostics (4,605 words) [view diff] exact match in snippet view article find links to article
Angius A, Cao A (January 1980). "Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in
Stefan Karlsson (professor) (1,009 words) [view diff] exact match in snippet view article
Papayannopoulou, T; Nienhuis, AW (August 1988). "Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic
Bat (18,222 words) [view diff] exact match in snippet view article find links to article
of the "Flying Primate" Hypothesis by Phylogenetic Evidence from the ε-globin Gene". Science. 256 (5053): 86–89. Bibcode:1992Sci...256...86B. doi:10.1126/science
SLC66A3 (748 words) [view diff] exact match in snippet view article find links to article
interaction with GATA-2. Krueppel like transcription factors Involved in β-globin expression and the development of erythrocytes. GATA binding factors Involved
Haplogroup E-M2 (8,800 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. S2CID 73503158. Yaseen, Noor Taha; et al. (2020). "Sickle ß-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Alice in Chains (18,852 words) [view diff] exact match in snippet view article find links to article
(played by William DuVall), Black Metal musician Unta Gleeben Glabben Globben Globin (played by Mike Inez) and the hipster Stanley Eisen (played by Sean Kinney)
Idiopathic orbital inflammatory disease (1,634 words) [view diff] exact match in snippet view article find links to article
immunosuppressants (methotrexate, cyclosporine, azathioprine), IV immune-globin, plasmapheresis, and biologic treatments (such as TNF-α inhibitors). IOI
Zinc-finger nuclease (4,657 words) [view diff] exact match in snippet view article find links to article
include the causes of monogenic diseases, such as the IL2Rγ gene and the β-globin gene for gene correction and CCR5 gene for mutagenesis and disablement.
Genetic distance (4,732 words) [view diff] exact match in snippet view article find links to article
based on evolutionary events (fossil records). For example, gene for alpha-globin (constituent of hemoglobin) mutates at a rate of 0.56 per base pair per
KLF4 (6,840 words) [view diff] exact match in snippet view article find links to article
functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases
Meinrad Busslinger (1,031 words) [view diff] exact match in snippet view article find links to article
discovered that a single nucleotide mutation in the first intron of the β-globin gene causes β+-thalassemia and that DNA methylation of promoter sequences
Nuclear run-on (682 words) [view diff] exact match in snippet view article find links to article
"Clustering of RNA polymerase B molecules in the 5' moiety of the adult beta-globin gene of hen erythrocytes". Nucleic Acids Res. 9 (11): 2589–98. doi:10.1093/nar/9
Hygiene hypothesis (5,681 words) [view diff] exact match in snippet view article find links to article
Kanjaksha, Ghosh (February 2018). "Plasmodium falciparum malaria skews globin gene expression balance in in-vitro haematopoietic stem cell culture system:
DNA unwinding element (2,303 words) [view diff] exact match in snippet view article find links to article
initiation zone areas, associated with known proteins like the c-myc and β-globin gene. Ones with DUEs thought to act in nearly same way as yeast cells. DUE
Cell engineering (1,592 words) [view diff] exact match in snippet view article find links to article
(1988-10-30). "Cloning, characterization and expression of the bacterial globin gene from Vitreoscilla in Escherichia coli". Gene. 70 (2): 377–386. doi:10
Mutagenesis (molecular biology technique) (2,895 words) [view diff] exact match in snippet view article
"Site-directed mutagenesis in DNA: generation of point mutations in cloned beta globin complementary dna at the positions corresponding to amino acids 121 to 123"
Arabs (29,857 words) [view diff] exact match in snippet view article find links to article
geographic origins is reflected, for example, in the heterogeneous spectrum of globin mutations among Israeli Arabs (Filon et al. 1994). Israeli and Palestinian
Helicase (6,916 words) [view diff] exact match in snippet view article find links to article
ATRX gene causes the downregulation of gene expression, such as the alpha-globin genes. It is still unknown what causes the expression of the various characteristics
Katherine A. High (1,439 words) [view diff] exact match in snippet view article find links to article
Edward J Benz Jr, during which she worked on the molecular genetics of globin genes and oncogenes. High has been recognized for her distinguished contributions
Julian Gough (scientist) (2,031 words) [view diff] exact match in snippet view article
Guertin, M; Gough, J; Dewilde, S; Moens, L; Vanfleteren, J. R. (2005). "Three globin lineages belonging to two structural classes in genomes from the three kingdoms
Beverly M. Emerson (989 words) [view diff] exact match in snippet view article find links to article
breast tissue can promote early cancer formation. She has studied the Beta globin gene family, and found it is activated by EKLF, a zinc finger containing
Donat Mg (1,915 words) [view diff] exact match in snippet view article find links to article
Rogaška Slatina resort, 2002 http://www.donatmg.eu/en/zgodovina-rogaska_iz_globin.php[permanent dead link] History of Donat Mg http://www.donatmg.eu/en/100let-dejstva
The Devil Put Dinosaurs Here (4,406 words) [view diff] exact match in snippet view article find links to article
Cleveland (played by DuVall), black metal musician Unta Gleeben Glabben Globben Globin (played by bassist Mike Inez), and the hipster Stanley Eisen (played by
Vectors in gene therapy (4,918 words) [view diff] exact match in snippet view article find links to article
zinc finger nucleases or by including certain sequences such as the beta-globin locus control region to direct the site of integration to specific chromosomal
Ben F. Koop (692 words) [view diff] exact match in snippet view article find links to article
California Institute of Technology Thesis Expression and evolution of mammalian beta-globin genes (1988) Academic work Institutions University of Victoria
Ben F. Koop (692 words) [view diff] exact match in snippet view article find links to article
California Institute of Technology Thesis Expression and evolution of mammalian beta-globin genes (1988) Academic work Institutions University of Victoria
HBS1 like translational GTPase (844 words) [view diff] exact match in snippet view article find links to article
Orkin SH (2008). "DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell
Caricain (2,014 words) [view diff] exact match in snippet view article find links to article
specificities of chymopa- pain and papaya Ω proteinase determined by digestion of α-globin chains. Biol. Chem. Hoppe-Seyler 370, 819–829. Johansen, J.T., Ottesen,
Moderna COVID-19 vaccine (13,038 words) [view diff] exact match in snippet view article find links to article
5' untranslated region (UTR) and a 3' UTR derived from the human alpha globin gene (HBA1), introduction of two additional stop codons, terminated by a
Homologous recombination (12,105 words) [view diff] exact match in snippet view article find links to article
(1985-09-19). "Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination". Nature. 317 (6034): 230–4. Bibcode:1985Natur
CUT&RUN sequencing (2,049 words) [view diff] exact match in snippet view article find links to article
of the new CUT&RUN technology. In humans, researchers looking at fetal globin gene promoters have used CUT&RUN to investigate the involvement of the protein
Burghardt Wittig (2,139 words) [view diff] exact match in snippet view article find links to article
S; Wittig, B; Rich, A (1996). "Z-DNA forming sites within the human b-globin gene cluster". Proc. Natl. Acad. Sci. USA. 93 (2): 780–784. Bibcode:1996PNAS
History of RNA biology (4,630 words) [view diff] exact match in snippet view article find links to article
quantities of mRNA that are highly enriched in RNA encoding alpha- and beta-globin (the two major protein chains of hemoglobin). The first direct experimental
Gene gating (1,588 words) [view diff] exact match in snippet view article find links to article
has also been observed in human cell lines. The human Mash1, GAFB and β-globin loci have all been observed moving away from the nuclear periphery when
Genetically modified organism (24,587 words) [view diff] exact match in snippet view article find links to article
PMID 6272397. Costantini F, Lacy E (November 1981). "Introduction of a rabbit beta-globin gene into the mouse germ line". Nature. 294 (5836): 92–4. Bibcode:1981Natur
List of eponymous medical signs (113 words) [view diff] exact match in snippet view article find links to article
indicates a specific cause of death in some stillborns Loss of all four alpha-globin genes (total alpha-thalassemia) leads to severely anemic stillborn babies
Afro-Mexicans (11,326 words) [view diff] exact match in snippet view article find links to article
Afromestizo population through the analysis of the 3' haplotype of the beta globin gene in betaA chromosomes". Blood Cells, Molecules & Diseases. 39 (2): 169–177
DMAC1 (1,592 words) [view diff] exact match in snippet view article find links to article
in the cardiovascular system and two binding sites for GATA1 which is a globin transcription factor 1 involved in erythroblast development regulation.
List of biophysically important macromolecular crystal structures (2,701 words) [view diff] exact match in snippet view article find links to article
but it clearly had the same basic 8-helix architecture (now called the "globin fold"). Further hemoglobin crystal structures at higher resolution (PDB
SATB1 (3,024 words) [view diff] exact match in snippet view article find links to article
family protein expressed during early erythroid differentiation modifies globin gene expression". Blood. 105 (8): 3330–3339. doi:10.1182/blood-2004-08-2988
LL-100 panel (4,749 words) [view diff] exact match in snippet view article find links to article
cells: a new human erythroleukemia cell line with spontaneous and induced globin expression". Science. 216 (4551): 1233–5. Bibcode:1982Sci...216.1233M. doi:10
Pfizer–BioNTech COVID-19 vaccine (21,487 words) [view diff] exact match in snippet view article find links to article
five prime untranslated region derived from the sequence of human alpha globin; a signal peptide (bases 55–102) and two proline substitutions (K986P and
Hemoglobin O-Arab (1,091 words) [view diff] exact match in snippet view article find links to article
sickle cell anaemia. A description with the presence of two variations of β-globin chains, β^6Glu → Val (HbS) and β^121Glu → Lys (Hb O-Arab), patients heterozygous
MAGIChip (2,377 words) [view diff] exact match in snippet view article find links to article
individual gel pads. This procedure was applied to the identification of beta-globin gene mutation in the patients of beta thalassemia patients and to detection
Amino acid replacement (1,451 words) [view diff] exact match in snippet view article find links to article
known example in humans is sickle cell anemia, due to a mutation in beta globin where at position 6 glutamic acid (negatively charged) is exchanged with
History of genetic engineering (6,333 words) [view diff] exact match in snippet view article find links to article
PMID 6272397. Costantini, F.; Lacy, E. (1981). "Introduction of a rabbit β-globin gene into the mouse germ line". Nature. 294 (5836): 92–94. Bibcode:1981Natur
Genetically modified animal (11,039 words) [view diff] exact match in snippet view article find links to article
PMID 6272397. Costantini F, Lacy E (November 1981). "Introduction of a rabbit beta-globin gene into the mouse germ line". Nature. 294 (5836): 92–4. Bibcode:1981Natur
Edward F. Fritsch (709 words) [view diff] exact match in snippet view article find links to article
Tom (1978-12-01). "The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA". Cell. 15 (4): 1157–1174. doi:10
Canis lupus dingo (8,526 words) [view diff] case mismatch in snippet view article find links to article
Bernadine; Thompson, Judith (1979). "THE AMINO ACID COMPOSITION OF αT-13 OF GLOBIN FROM a PURE BRED DINGO (CANIS FAMILIARIS DINGO)". Australian Journal of
MRNA surveillance (3,394 words) [view diff] exact match in snippet view article find links to article
formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs". The EMBO Journal. 20 (3): 532–40. doi:10.1093/emboj/20.3.532. PMC 133467
Jens Nielsen (2,549 words) [view diff] exact match in snippet view article find links to article
José L.; Liu, Zihe; Petranovic, Dina; Nielsen, Jens (2014). "Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin
H3S28P (2,039 words) [view diff] exact match in snippet view article find links to article
discovered that phosphorylating H3S28 in the promoters of genes like c-fos and -globin controlled their activation. In addition to H3K27ac, H3S28p plays a role
ASH1L (3,070 words) [view diff] exact match in snippet view article find links to article
action. Knockdown of ASH1L in K562 cells causes up-regulation of the ε-globin gene and down-regulation of myelomonocytic markers GPIIb and GPIIIa, and
Neal S. Young (1,589 words) [view diff] exact match in snippet view article find links to article
Anfinsen (in the immunochemistry of hemoglobin) and Arthur Nienhuis (in globin gene regulation). He directed the first multicenter clinical trial using
Transfusion-dependent anemia (2,866 words) [view diff] exact match in snippet view article find links to article
of anemia. Beta-thalassemia is a genetic disease mostly caused by beta-globin gene mutations. Clinical diagnosis is based on interpretation of the peripheral
Aché (8,314 words) [view diff] exact match in snippet view article find links to article
Petzl-Erler, Kim Hill, A. Magdalena Hurtado, and Mara H. Hutz. The Beta-Globin Gene Cluster Distribution Revisited—Patterns in Native American Populations
Insulated neighborhood (2,487 words) [view diff] exact match in snippet view article find links to article
Whiteley, M; Felsenfeld, G (13 August 1993). "A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against
Michael P. Snyder (2,263 words) [view diff] exact match in snippet view article find links to article
Weissman, S. M.; Snyder, M. (2002). "GATA-1 binding sites mapped in the beta-globin locus by using mammalian chIp-chip analysis - PubMed". Proceedings of the
Ross Hardison (1,382 words) [view diff] exact match in snippet view article find links to article
(1979). "The structure and transcription of four linked rabbit beta-like globin genes". Cell. 18 (4): 1285–1297. doi:10.1016/0092-8674(79)90239-3. ISSN 0092-8674
History of West Africa (24,731 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. S2CID 73503158. Yaseen, Noor Taha; et al. (January 2020). "Sickle β-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
H3S10P (2,389 words) [view diff] exact match in snippet view article find links to article
targeting H3S28 phosphorylation to promoters of genes such as c-fos and α-globin was shown to control their activation.53 Notably, phosphorylation of H3S10
Genetic history of Africa (16,057 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. Yaseen NT, Al-Mamoori HS, Hassan MK (January 2020). "Sickle β-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Recôncavo Baiano (929 words) [view diff] exact match in snippet view article find links to article
Silva, Wellington; Guimarães, Maria de Nazaré; Grisolia, Cesar (2010). "β-globin haplotypes in normal and hemoglobinopathic individuals from Reconcavo Baiano
Genetic history of the African diaspora (15,475 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. S2CID 73503158. Yaseen, Noor Taha; et al. (2020). "Sickle ß-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Laura Manuelidis (3,866 words) [view diff] exact match in snippet view article find links to article
progression. Finally, the insertion of a huge 11 megabase transgene of the globin exon (lacking introns) was recognized by cells, and silenced by compaction
Trinucleotide repeat expansion (7,973 words) [view diff] exact match in snippet view article find links to article
for a homologous repeat misalignment, commonly known for causing alpha-globin locus deletions, causes the meiotic instability of a trinucleotide repeat
G-quadruplex (11,903 words) [view diff] exact match in snippet view article find links to article
to form G-quadruplexes in their promoter regions include the chicken β-globin gene, human ubiquitin-ligase RFP2, and the proto-oncogenes c-kit, bcl-2
Global coordination level (913 words) [view diff] exact match in snippet view article find links to article
gene repression: Increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice". Proceedings of the National Academy
List of examples of convergent evolution (14,866 words) [view diff] exact match in snippet view article find links to article
Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity by Lechauve, Christophe; Jager, Muriel; Laguerre, Laurent; Kiger
Circulating free DNA (4,221 words) [view diff] exact match in snippet view article find links to article
Rainer TH, Lam NY, Man CY, Chiu RW, Woo KS, Lo YM (June 2006). "Plasma beta-globin DNA as a prognostic marker in chest pain patients". Clinica Chimica Acta;
Clinical metagenomic sequencing (3,492 words) [view diff] exact match in snippet view article find links to article
I for DNA background, or by removing abundant RNA species (rRNA, mtRNA, globin mRNA) using sequence-specific RNA depletion kits. Also CRISPR-Cas9-based
Phylogenetic reconciliation (15,300 words) [view diff] exact match in snippet view article find links to article
Lineage, a Parsimony Strategy Illustrated by Cladograms Constructed from Globin Sequences". Systematic Zoology. 28 (2): 132–163. doi:10.2307/2412519. JSTOR 2412519
Marcelo Jacobs-Lorena (1,033 words) [view diff] exact match in snippet view article find links to article
Massachusetts Institute of Technology Thesis Characterization of extraribosomal globin messenger RNA and human histone messenger RNA (1972) Academic work Institutions
Off-target genome editing (6,846 words) [view diff] exact match in snippet view article find links to article
EJ, Antico CJ, Bao G (November 2013). "CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity". Nucleic Acids Research
List of acts of the 112th United States Congress (323 words) [view diff] exact match in snippet view article find links to article
administration, within the homes of Medicare beneficiaries, of intravenous immune globin (IVIG) for the treatment of primary immune deficiency diseases. 112-243
List of California Institute of Technology people (14,263 words) [view diff] exact match in snippet view article find links to article
particularly as it relates to eukaryotic gene expression; and regulation of globin gene expression during development; member of National Academy of Sciences
Alexander Silberman Institute of Life Sciences (2,100 words) [view diff] exact match in snippet view article find links to article
H.; Littauer, U. Z. (March 1977). "Degradation of deadenylated rabbit α-globin mRNA in Xenopus oocytes is associated with its translation". Nature. 266
Population history of West Africa (17,587 words) [view diff] exact match in snippet view article find links to article
Taha; Al-Mamoori, Hind Shaker; Hassan, Mea` Kadhum (2020-04-15). "Sickle ß-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Murine respirovirus (31,886 words) [view diff] exact match in snippet view article find links to article
cells: a new human erythroleukemia cell line with spontaneous and induced globin expression". Science. 216 (4551): 1233–5. Bibcode:1982Sci...216.1233M. doi:10
Prehistoric West Africa (14,687 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. S2CID 73503158. Yaseen, Noor Taha; et al. (2020). "Sickle ß-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Split gene theory (8,033 words) [view diff] exact match in snippet view article find links to article
Organism Lariat Consensus sequence Yeast TACTAAC Human Beta globin genes CTGAC CTAAT CTGAT CTAAC CTCAC Drosophila CTAAT Rats CTGAC Plants (C/T)T(A/G)A(T/C)
Genetic history of West Africa (3,012 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. Yaseen NT, Al-Mamoori HS, Hassan MK (January 2020). "Sickle β-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Prehistoric Central Africa (5,086 words) [view diff] exact match in snippet view article find links to article
PMID 30827499. S2CID 73503158. Yaseen, Noor Taha; et al. (2020). "Sickle ß-globin haplotypes among patients with sickle cell anemia in Basra, Iraq: A cross-sectional
Origin of the Palestinians (13,955 words) [view diff] exact match in snippet view article find links to article
geographic origins is reflected, for example, in the heterogeneous spectrum of globin mutations among Israeli Arabs (Filon et al. 1994). Israeli and Palestinian