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searching for Free fraction 19 found (22 total)

Elimination (pharmacology) (933 words) [view diff] exact match in snippet view article

metabolites that are not bound to proteins present in blood plasma (free fraction) and many other types of drugs (such as the organic acids) are actively

Mössbauer effect (1,170 words) [view diff] exact match in snippet view article find links to article

without recoil. He attributed the observed resonance to this recoil-free fraction of nuclear events. The Mössbauer effect was one of the last major discoveries

Dessau-Roßlau (576 words) [view diff] case mismatch in snippet view article find links to article

Pro Dessau-Roßlau (independent): 4 Forum-Bürgerliste (independent): 4 Free Fraction Dessau-Roßlau (independent): 3 Free Democratic Party (FDP): 2 The Lord

Meloxicam (3,733 words) [view diff] exact match in snippet view article find links to article

concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower

Cetirizine (3,297 words) [view diff] exact match in snippet view article find links to article

contribute much less to total plasma protein binding. The unbound or free fraction of levocetirizine has been reported to be 8%. The true volume of distribution

Nisoxetine (2,772 words) [view diff] exact match in snippet view article find links to article

lipophilicity, reasonable stability in plasma, as well as high plasma free fraction. 11C-labeled nisoxetine, synthesized by Haka and Kilbourn, was one possible

Sodium thiopental (3,723 words) [view diff] exact match in snippet view article find links to article

leading to sequestration in fatty tissue. Once redistributed, the free fraction in the blood is metabolized in the liver by zero-order kinetics. Sodium

Bromazepam (4,287 words) [view diff] exact match in snippet view article find links to article

that the elimination half-life, peak serum concentration, and serum free fraction are significantly elevated and the oral clearance and volume of distribution

Mössbauer spectroscopy (3,665 words) [view diff] exact match in snippet view article find links to article

should be relatively low, otherwise the system will have a low recoil-free fraction resulting in a poor signal-to-noise ratio and requiring long collection

Haloperidol (4,889 words) [view diff] exact match in snippet view article find links to article

stopped. Haloperidol is heavily protein bound in human plasma, with a free fraction of only 7.5 to 11.6%. It is also extensively metabolized in the liver

Human serum albumin (4,051 words) [view diff] exact match in snippet view article find links to article

albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency. Competitively binds

Alpidem (4,669 words) [view diff] exact match in snippet view article find links to article

fractions bound to albumin (97.0%) and α1-acid glycoprotein (97.3%). The free fraction of alpidem is slightly higher in people with cirrhosis (0.86 ± 0.06%)

Testosterone (15,740 words) [view diff] exact match in snippet view article find links to article

testosterone bound to SHBG is lower in men than in women. Both the free fraction and the one bound to albumin are available at the tissue level (their

Dienogest (5,628 words) [view diff] exact match in snippet view article find links to article

plasma protein binding of dienogest is 90%, with a relatively high free fraction of 10%. It is exclusively bound to albumin, with no binding to SHBG

Tbf5 protein domain (526 words) [view diff] exact match in snippet view article find links to article

function of the complex. TTDA is present both bound to TFIIH, and as a free fraction that shuffles between the cytoplasm and nucleus; induction of NER-type

Diethylstilbestrol (11,654 words) [view diff] exact match in snippet view article find links to article

production, thereby increasing circulating levels of SHBG and decreasing the free fraction of testosterone and dihydrotestosterone (DHT) in the circulation; and

Kinetic exclusion assay (2,005 words) [view diff] exact match in snippet view article find links to article

receptors LT = total concentration of ligand A simple equation relating the free fraction of R (=R/RT) to the Kd and LT is then fit to the measured data to find

Pharmacokinetics of estradiol (26,822 words) [view diff] exact match in snippet view article find links to article

parenteral estradiol routes by some amount. However, a study found that the free fraction of estradiol was similar with doses of oral and topical estradiol that

Saliva testing (8,483 words) [view diff] no match in snippet view article find links to article

(SHBG) or albumin, they are regarded as reflecting only the bioactive ("free") fraction. With continued research into the field of salivary testing, accuracy