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searching for First pass effect 13 found (63 total)

Rectal administration (1,252 words) [view diff] no match in snippet view article find links to article

administration are largely the same as with medicinal drugs: Bypassing the first-pass effect, fast onset, and a relatively high bioavailability with some drugs

Pharmacokinetics of progesterone (18,992 words) [view diff] no match in snippet view article find links to article

parenteral progesterone, such as with vaginal administration, avoids the first-pass effect, and is not associated with supraphysiological levels of neurosteroid

Hydralazine (1,332 words) [view diff] no match in snippet view article find links to article

tranquillisers Ethanol (alcohol) Diazoxide Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine

Adult stem cell (5,969 words) [view diff] exact match in snippet view article find links to article

method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenously injected cells are sequestered in the lungs.

Pharmacology (4,749 words) [view diff] exact match in snippet view article find links to article

administration and the drug concentration after an IV administration (first pass effect is avoided and therefore no amount drug is lost). A drug must be lipophilic

Budesonide (3,260 words) [view diff] exact match in snippet view article find links to article

/ Rx-only EU: Rx-only Pharmacokinetic data Bioavailability 10-20% (first pass effect) Protein binding 85-90% Metabolism Liver CYP3A4 Elimination half-life

Lorazepam (8,688 words) [view diff] no match in snippet view article find links to article

"Disposition of lorazepam in human beings: enterohepatic recirculation and first-pass effect". Clinical Pharmacology and Therapeutics. 46 (1): 18–25. doi:10.1038/clpt

Primary ovarian insufficiency (4,792 words) [view diff] exact match in snippet view article find links to article

of pulmonary embolism and deep venous thrombosis by avoiding the first pass effect on the liver that is induced by oral estrogen therapy. The transdermal

Mephedrone (13,613 words) [view diff] no match in snippet view article find links to article

is relatively low, at about 10% in rats, suggesting a significant first-pass effect. The percentage of mephedrone bound to plasma proteins is approximately

Discovery and development of beta2 agonists (3,067 words) [view diff] exact match in snippet view article find links to article

after oral administration a more pronounced metabolic clearance (high first pass effect) is responsible for a low bioavailability. The elimination after inhalation

Macy catheter (2,022 words) [view diff] exact match in snippet view article find links to article

the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many

Bioenhancer (2,375 words) [view diff] no match in snippet view article find links to article

Especially the latter two enzymes contribute significantly to the first-pass effect. Piperine acts as bioenhancer to vitamins (A, B1, B2, B6, C, D, E

Treatment of equine lameness (12,678 words) [view diff] exact match in snippet view article find links to article

be partially due to its poor oral bioavailability (2.2%) and high first pass effect. While pentoxyfylline has a better bioavailability after oral dosing