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alternate case: domain of unknown function
ORF8
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exemplified in SARS-CoV-2, encodes a protein with an immunoglobulin domain of unknown function, possibly involving interactions with the host immune system.YqeY protein domain (236 words) [view diff] exact match in snippet view article find links to article
In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the productionTMEM242 (1,527 words) [view diff] case mismatch in snippet view article find links to article
scientific community. This protein contains a DUF1358 domain (Domain of Unknown Function 1358). Several predicted interacting proteins and functional sitesVitellin (657 words) [view diff] exact match in snippet view article find links to article
the four domains of this protein structure. The honey bees, the domain of unknown function 1943 (DUF1943), and the von Willebrand factor (vWF) type D domainTransmembrane protein 134 (548 words) [view diff] exact match in snippet view article find links to article
other known aliases. There are two transmembrane domains and a domain of unknown function (DUF872). Evolutionary, the majority of the organisms that haveFAM83A (1,311 words) [view diff] exact match in snippet view article find links to article
by the FAM83A gene. This protein is predicted to contain one domain of unknown function 1669 (DUF1669), which places this protein into the PLDc_SuperFamilyMafB toxins (160 words) [view diff] exact match in snippet view article find links to article
polymorphic toxins. The N-terminal region of MafB proteins harbors a domain of unknown function named DUF1020 while the C-terminal region is variable and harborsFAM185A (788 words) [view diff] exact match in snippet view article find links to article
characterized by the presence of multiple copies of DUF4098 (Domain of unknown function, 4098) near its C-terminus. It is described as a Long InterspersedFAM167A (1,196 words) [view diff] exact match in snippet view article find links to article
of unknown function. FAM167A has many orthologs in which the domain of unknown function is highly conserved. On chromosome 8, FAM167A is positioned betweenReeler domain (263 words) [view diff] exact match in snippet view article find links to article
receptor(s) expressed on both hippocampal and sensory neurons. This domain of unknown function is found at the N terminus of reelin and F-spondin. Human genesVXN (806 words) [view diff] exact match in snippet view article find links to article
show conservation of the SH3 protein domain family as well as a domain of unknown function (DUF4648). VXN does not have any alternative mRNA splice variantsC10orf35 (504 words) [view diff] exact match in snippet view article find links to article
protein-binding, transmembrane protein. The protein contains the domain of unknown function 4605 (DUF4605) which belongs to the protein family pfam15378.Protein FAM46B (1,637 words) [view diff] exact match in snippet view article find links to article
humans is encoded by the FAM46B gene. FAM46B contains one protein domain of unknown function, DUF1693. Yeast two-hybrid screening has identified three proteinsUncharacterized LOC644249 gene (771 words) [view diff] exact match in snippet view article find links to article
pfam 12001. In particular, this conserved domain contains the domain of unknown function DUF3496 which is about 110 amino acids long, functionally uncharacterizedFAM46C (908 words) [view diff] exact match in snippet view article find links to article
is found on chromosome 1 at the locus 1p12 FAM46C contains one domain of unknown function, DUF1693, and as such has been placed in the DUF1693 protein familyTetratricopeptide repeat protein 39B (1,318 words) [view diff] exact match in snippet view article find links to article
The main feature within tetratricopeptide repeat 39B is the domain of unknown function 3808 (DUF3808), spanning the majority of the protein. The geneKIAA0895L (655 words) [view diff] exact match in snippet view article find links to article
complexity at 2913-2917 bp in the 3’ UTR region. There is a conserved domain of unknown function, known as DUF1704, located at 1390-2083 bp. The following is aC8orf82 (666 words) [view diff] exact match in snippet view article find links to article
conserved among bacteria, archaea, plants, fungi, or trichoplax. The domain of unknown function DUF4505 seems to be well conserved among most orthologs. BelowC13orf38 (842 words) [view diff] exact match in snippet view article find links to article
human CCDC169 gene contains 753 nucleotides. C13orf contains a domain of unknown function DUF4600. which is conserved in between nucleotide interval 1-79MGC50722 (1,555 words) [view diff] exact match in snippet view article find links to article
acid human protein has a molecular weight of 104.495 kDa and one domain of unknown function (DUF390). Generally conserved across mammals, this quickly evolvingCCDC94 (962 words) [view diff] exact match in snippet view article find links to article
CCDC94 gene. The CCDC94 protein contains a coiled-coil domain, a domain of unknown function (DUF572), an uncharacterized conserved protein (COG5134), andCAPN10 (1,079 words) [view diff] exact match in snippet view article find links to article
activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. TheABHD18 (680 words) [view diff] exact match in snippet view article find links to article
bacterial homologs indicate a horizontal gene transfer event. The domain of unknown function, DUF2048, is conserved throughout orthologs. ABHD18 codes a 414FAM98C (1,202 words) [view diff] exact match in snippet view article find links to article
residues. FAM98C has a domain of unknown function 2465 (DUF2465) from the amino acids 18-334. This domain of unknown function is unique to the FAM98 familySOGA2 (1,538 words) [view diff] case mismatch in snippet view article find links to article
isoforms: Q9Y4B5-1, Q9Y4B5-2, Q9Y4B5-3, Q9Y4B5-4. SOGA2 contains Domain of Unknown Function 4201 (DUF4201) from aa 16-235. This domain is specific to theC17orf53 (1,349 words) [view diff] exact match in snippet view article find links to article
own. C17orf53 falls within two distinct families; DUF4539, a domain of unknown function, and PRR18 super family, which consists of a proline rich familyC2orf81 (868 words) [view diff] exact match in snippet view article find links to article
respectively. C2orf81 is the only member of superfamily cl25621. Domain of unknown function (DUF) 4639 is unique to the c2orf81 protein and is conserved inCCDC90B (267 words) [view diff] exact match in snippet view article find links to article
(MAGUK) family This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire proteinCCDC116 (361 words) [view diff] exact match in snippet view article find links to article
has an isoelectric point of 9.24. This protein is a part of the domain of unknown function 4702. It is predicted that CCDC116 is located in the nucleus.C1orf198 (2,290 words) [view diff] exact match in snippet view article find links to article
site, including introns, is 32,470 bp. This gene also contains a domain of unknown function called DUF4706. In total, C1orf198 has 4 exons. RNA-seq tissueTMEM229B (631 words) [view diff] exact match in snippet view article find links to article
molecular weight of 19,531 daltons. The TMEM229B protein contains a domain of unknown function, part of the domain family DUF1113, spanning from amino acidsTM6SF2 (1,255 words) [view diff] exact match in snippet view article find links to article
paralog of TM6SF2 in humans about which little is known. The domain of unknown function DUF2781 is highly conserved across homologs. DUF2781 belongs toC1orf21 (1,235 words) [view diff] exact match in snippet view article find links to article
with 4 exons. The protein is 121 amino acids long, containing a domain of unknown function known as DUF4612. NCBI gene and RNA-Seq revealed that C1orf21FAM63B (1,235 words) [view diff] exact match in snippet view article find links to article
FAM63B is a member of the Pfam super family, and contains a domain of unknown function (DUF544) that is homologous within the protein family. FAM63BFAM49A (484 words) [view diff] case mismatch in snippet view article find links to article
The protein contains two domains: Residues 15-319 comprise the "Domain of Unknown Function 1394" (DUF1394, Pfam PF07159). Residues 67->281 comprise the "CytoplasmicSSMEM1 (460 words) [view diff] exact match in snippet view article find links to article
domain region spanning amino acids 35-55. This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243)PRR29 (1,505 words) [view diff] exact match in snippet view article find links to article
rich region within its sequence from amino acids 73 to 166. A domain of unknown function, DUF 4587, is also present from amino acids 39 to 112 or 113.C11orf42 (1,136 words) [view diff] exact match in snippet view article find links to article
searching through [NCBI], it was found that C11orf42 only had a domain of unknown function called DUF4463, which is conserved from humans to worms. The DUF4463C4orf45 (1,439 words) [view diff] exact match in snippet view article find links to article
and its molecular weight is 21.6 kDa. The protein contains a domain of unknown function, DUF4562. It is also predicted to contain a forkhead-associatedC1orf167 (1,178 words) [view diff] exact match in snippet view article find links to article
hyper-phosphorylation of C1orf167 in H. sapiens and five of its orthologs. One domain of unknown function, located from 954aa-1418aa, is 465 amino acids in length. C1orf167KIAA0090 (1,126 words) [view diff] exact match in snippet view article find links to article
WD40 like domain, a leucine zipper domain, a DUF1620 domain (domain of unknown function), and a transmembrane domain. These can be viewed in Figure 2NBEAL1 (1,439 words) [view diff] exact match in snippet view article find links to article
DUF4704, DUF4800, PH_BEACH, Beach, and WD40 repeats. DUF4704 is a domain of unknown function. While the function of this domain is unknown, it is conservedC11orf1 (835 words) [view diff] exact match in snippet view article find links to article
superfamily. This family is characterized by the presence of a domain of unknown function (DUF)1143 shared by the family. This family DUF1143 has a domainC12orf40 (713 words) [view diff] exact match in snippet view article find links to article
and its isoelectric point 7.822. Amino acids 229-652 contain a domain of unknown function (DUF4552) which is conserved in vertebrates. C12orf40 is predictedCCDC138 (1,124 words) [view diff] exact match in snippet view article find links to article
primary isoform (Isoform 1) to the secondary isoform (Isoform 2). A domain of unknown function (DUF2317) on the protein at location 212 – 315 has been characterizedSEPTIN4 (570 words) [view diff] exact match in snippet view article find links to article
cytosol, the nucleus, and mitochondrion. C17orf47 contains a domain of unknown function DUF4655, which has a length characteristic of that DUF familyANKRD26 (854 words) [view diff] exact match in snippet view article find links to article
associated with ATPase involved in DNA repair. There is also a domain of unknown function from amino acid 1538–1649. In humans ANKRD26 was seen to be mostRTL6 (1,947 words) [view diff] exact match in snippet view article find links to article
a domain of unknown function from amino acid residues 98-177 . RTL6 is one of a number of genes belonging to the DUF4939 (domain of unknown function) superfamilyFAM214B (1,338 words) [view diff] exact match in snippet view article find links to article
position 10 to 25, and 225 to 265. The FAM214B contains a DUF4210 domain of unknown function at the position 348 to 402, and a chromosome segregation domainTMEM69 (685 words) [view diff] exact match in snippet view article find links to article
length. Five transmembrane segments are present as well as a domain of unknown function, DUF3429, which spans amino acids 91-232. Properties of TMEM69Tex36 (1,682 words) [view diff] exact match in snippet view article find links to article
Biochem. Sci, 24(1) 34-35 (1999). EMBL-EBI, InterPro. "Species: Domain of unknown function with conserved HDNR motif (IPR029369) < InterPro < EMBL-EBI".Proser1 (374 words) [view diff] exact match in snippet view article find links to article
particularly low in any other amino acids. PROSER1 contains one domain of unknown function, DUF 4476, part of pfam14771. The DUF spans from amino acids 26C11orf52 (656 words) [view diff] exact match in snippet view article find links to article
between threonine and arginine. The 123 amino acid chain is a domain of unknown function. It has a molecular weight of 13,9 kDal and a predicted IsoelectricEFHC2 (891 words) [view diff] exact match in snippet view article find links to article
The schematic shows key features of the protein encoded by the EFHC2 gene in humans. "DUF" refers to "domain of unknown function."C7orf61 (585 words) [view diff] exact match in snippet view article find links to article
lacks isoforms. The mRNA is approximately 1019 bp and belongs to domain of unknown function 4703 (PFAM15775). In humans, the protein contains a total of 206C14orf102 (493 words) [view diff] exact match in snippet view article find links to article
(histone acetyltransferase) domains, a coiled coil domain, a domain of unknown function, a lysine-rich region, and a poly-lysine and serine region. FurtherTMEM143 (1,137 words) [view diff] exact match in snippet view article find links to article
weight of 51.6 kDa and an isoelectric point of 9.7 in humans. A domain of unknown function (DUF3754) is present within which two transmembrane domains resideKIAA0753 (880 words) [view diff] exact match in snippet view article find links to article
acids in length, and contains two notable domains. The first is a domain of unknown function, designated as DUF3498, which spans from amino acid 508 to 663TMEM249 (751 words) [view diff] exact match in snippet view article find links to article
part, with the largest changes in amino acids occurring in the domain of unknown function. ENSG00000285272 GRCh38: Ensembl release 89: ENSG00000261587,FAM222A (687 words) [view diff] exact match in snippet view article find links to article
FAM222A is a protein made of 452 amino acids. It contains a domain of unknown function called pfam15258 which is 200 amino acids long. It has been foundPRR23C (804 words) [view diff] exact match in snippet view article find links to article
weight of 27,674 Da. Proline-rich protein 23C Homo sapiens has a domain of unknown function (DUF2476) that spans the majority of the protein (1-259 aa) whichFAM98A (2,448 words) [view diff] exact match in snippet view article find links to article
component, a nuclear protein that binds to microtubules. FAM98A has a domain of unknown function 2465 (DUF2465) from the amino acids 10-329. Within the DUF2465CCDC109B (1,064 words) [view diff] case mismatch in snippet view article find links to article
conserved and contains domains crucial for protein function. Domain of Unknown Function 607 (DUF607): The function of this domain is largely unknown,Autophagy-related protein 101 (840 words) [view diff] exact match in snippet view article find links to article
the lysosome. The ATG101 protein contains an domain DUF1649 (domain of unknown function 1649). ATG101 is highly conserved among most vertebrates, includingC14orf93 (725 words) [view diff] exact match in snippet view article find links to article
C14orf93 is part of the family DUF4616; this family is marked by a domain of unknown function in the C-terminal domain. DUF4616 proteins are between 166 andMagnesium transporter1 family (758 words) [view diff] exact match in snippet view article find links to article
Fe2+ were without effect. MagT1 has an N-terminal thioredoxin domain of unknown function. Zhou and Clapham identified two mammalian genes, MagT1 and TUSC3C16orf86 (2,429 words) [view diff] case mismatch in snippet view article find links to article
This makes the protein acidic with a low PH. C16orf86 contains Domain of Unknown Function (DUF4691) from amino acid 1 to 184 and a Nuclear LocalizationTransmembrane protein 268 (1,045 words) [view diff] exact match in snippet view article find links to article
a molecular weight around 37.6 kdal. TMEM268 is a member of a domain of unknown function, DUF4481. The region is located within 37 and 328 in the aminoTransmembrane protein 53 (708 words) [view diff] exact match in snippet view article find links to article
The function of TMEM53 is not fully understood. It contains a domain of unknown function, DUF829, which is approximately 240 amino acids long. This domainC16orf95 (946 words) [view diff] exact match in snippet view article find links to article
the C16orf95 protein has 239 amino acids. It has a conserved domain of unknown function spanning residues 76 to 239. C16orf95 has a calculated molecularCoiled-coil domain containing 166 (1,183 words) [view diff] exact match in snippet view article find links to article
domains including a coiled-coil domain between amino acids 27-74, a domain of unknown function between amino acids 72-260, and a serine-rich domain between aminoChromosome 4 open reading frame 54 (686 words) [view diff] exact match in snippet view article find links to article
is significant expression in smooth muscle tissue. There is a domain of unknown function. The c4orf54 protein is myristylated with over 20 predicted sitesC9orf25 (760 words) [view diff] exact match in snippet view article find links to article
super family. The entire protein is still considered to be a domain of unknown function. C9orf25 has no signal sequence and remains in the cytosol. TheC11orf86 (1,161 words) [view diff] exact match in snippet view article find links to article
Domain of unknown function, DUF4633, and the C11orf86 gene.Glutamate rich 5 (745 words) [view diff] exact match in snippet view article find links to article
596 base pairs long. ERICH5 contains one conserved domain, a domain of unknown function called DUF4573. ERICH5 is predicted to contain two highly conservedRUFY2 (1,357 words) [view diff] exact match in snippet view article find links to article
signal transduction pathways and endosomal membrane trafficking. Domain of unknown function that is part of a family of hypothetical bacterial sequences pfam06156TANGO2 (1,368 words) [view diff] exact match in snippet view article find links to article
neuromuscular junctions, and in neurons. The NRDE (DUF883) domain, is a domain of unknown function spanning majority of the C22orf25 gene and is found among distantlyCCDC177 (1,675 words) [view diff] exact match in snippet view article find links to article
implicated in cell survival signaling. Humans CCDC177 includes one domain of unknown function (DUF4659), multiple disordered regions, and an alanine-rich motifLSMEM2 (1,269 words) [view diff] exact match in snippet view article find links to article
lumenal/extracellular region. It is found to have one domain, Domain of unknown function 4714 (DUF4714), spanning from amino acid 13 to 161. LSMEM2 isKIAA1841 (1,023 words) [view diff] exact match in snippet view article find links to article
ortholog. KAA1841 has evolved slowly and evenly over time. The domain of unknown function 3342 is conserved in all orthologs. It is the highest conservedTEDC2 (1,503 words) [view diff] exact match in snippet view article find links to article
sample western blot image is not available. TEDC2 contains a domain of unknown function, DUF4693, which in humans spans from proteins 148-431, approximatelyC1orf185 (1,220 words) [view diff] exact match in snippet view article find links to article
C1orf185 is a member of the pfam15842 protein family, containing a domain of unknown function, DUF4718. This family of proteins is between 130 and 224 aminoFGFR1OP2 (1,126 words) [view diff] exact match in snippet view article find links to article
signal sequences, and therefore is not secreted. FGFR1OP2 has a domain of unknown function, designated DUF837. Using the PELE program of Biology WorkBenchC6orf222 (1,399 words) [view diff] exact match in snippet view article find links to article
acid residues 535 to 611 in humans. C6orf222 contains a single domain of unknown function, DUF3292, found between amino acid residues 38-110. The proteinProtein ZGRF1 (1,714 words) [view diff] exact match in snippet view article find links to article
encoded for on the minus strand. ZGRF1 contains a DUF2439 domain (domain of unknown function), zf-GRF domain, and AAA_11 and an AAA_12 domain (ATPases associatedChromosome 12 open reading frame 71 (1,365 words) [view diff] exact match in snippet view article find links to article
coding sequence are comprising a disordered region, followed by a domain of unknown function (DUF4640) which spans almost the whole coding sequence. AdditionallyCEFIP (1,678 words) [view diff] exact match in snippet view article find links to article
This protein is Proline and Serine rich as well. One confirmed domain of unknown function (DUF) was found within the CEFIP protein sequence, DUF4585. DUF4585HIKESHI (2,195 words) [view diff] case mismatch in snippet view article find links to article
apparatus in lung cells. The protein domain known as DUF775 (Domain of Unknown Function 775) is located within both the human HIKESHI and mouse L7rn6RESF1 (1,434 words) [view diff] exact match in snippet view article find links to article
immune system. RESF1 is 1747 amino acids in length and has one domain of unknown function, DUF4617. The Molecular Weight of RESF1 is 194.9 kdal. The basalTEDDM1 (1,476 words) [view diff] exact match in snippet view article find links to article
amino acids relative to most proteins. TEDDM1 has a single major domain of unknown function entitled DUF716. This domain spans from amino acid position 95FAM149A (1,841 words) [view diff] exact match in snippet view article find links to article
and have conserved areas with FAM149A. FAM149A has a conserved domain of unknown function (DUF) 3719. The DUF 3719 has very little information. It is onlyLENG9 (1,513 words) [view diff] exact match in snippet view article find links to article
ZnF_C3H1 is found from amino acid 46 to 61. LENG9 also has a domain of unknown function belonging to the domain family DUF504, that spans from amino acidC15orf52 (1,204 words) [view diff] exact match in snippet view article find links to article
hsa-miR-203a-3p.1, and has-miR-214-5p miRNAs. The protein contains a domain of unknown function (DUF4594 from amino acid 185 to 350). The protein, C15orf52, isFAM166C (1,605 words) [view diff] exact match in snippet view article find links to article
than normal levels of isoleucine. The FAM166C protein has one domain of unknown function called DUF2475 from amino acids 19–85. FAM166C isoform 1 secondaryDNAJC28 (2,729 words) [view diff] exact match in snippet view article find links to article
motif between the second and third helices. There is a conserved domain of unknown function (DUF1992) from amino acids 203-272. There is a coiled-coil regionFAM214A (1,913 words) [view diff] case mismatch in snippet view article find links to article
n-terminus of the protein and two conserved domains including the Domain of Unknown Function 4210 (DUF4210) and a Chromosome_Seg domain near the c-terminusC11orf91 (636 words) [view diff] exact match in snippet view article find links to article
is 193 amino acids in length. The C11orf91 protein contains a domain of unknown function, DUF5529, that spans nearly the entire protein. RBMX protein bindingC1orf112 (1,625 words) [view diff] exact match in snippet view article find links to article
eight experimentally determined RefSeq isoforms. C1orf112 has a domain of unknown function DUF4487. Compositional analysis through SAPS predicted much lessBEND2 (protein) (1,817 words) [view diff] exact match in snippet view article
interactions sites are marked at the front of the protein. Two nuclear localization signals at the same site near a domain of unknown function (Unk).KIAA2013 (1,681 words) [view diff] exact match in snippet view article find links to article
of the mature protein. KIAA2013 contains one conserved protein domain of unknown function by the name of DUF2152, or pfam10222. This protein has remainedEthylene signaling pathway (2,898 words) [view diff] exact match in snippet view article find links to article
transmembrane domains towards the N-terminus, followed by a GAF domain of unknown function, and then signal output motifs in the C-terminal region. The N-terminusC14orf119 (2,146 words) [view diff] exact match in snippet view article find links to article
c14orf119 protein isoforms, as shown in the table below. There is a domain of unknown function (DUF) found in the c14orf119 protein: DUF4508 (with an E-valueZNF839 (1,473 words) [view diff] exact match in snippet view article find links to article
protein 839 is 6.18. This protein contains one zinc finger and one domain of unknown function (DUF) between amino acids 123-290. In isoforms 2-9, there is variabilityC15orf62 (1,798 words) [view diff] exact match in snippet view article find links to article
protein prenyltransferases alpha subunit repeat profile, and a domain of unknown function (DUF2437). C15orf62 contains a histidine kinase sensor, TorS sensorSea ice brine pocket (4,481 words) [view diff] exact match in snippet view article find links to article
PL, Mangiagalli M (March 2019). "Ice-binding proteins and the 'domain of unknown function' 3494 family" (PDF). The FEBS Journal. 286 (5): 855–873. doi:10